Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
GLUCOPYRANOSYL DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/144864
Kind Code:
A1
Abstract:
Provided are a glucopyranosyl derivative as a sodium-dependent glucose transporters inhibitor, especially as a SGLT1 inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, a pharmaceutical composition thereof, and the uses of the compound and pharmaceutical composition thereof in the preparation of drugs for the treatment of diabetes and diabetes-related diseases.

Inventors:
GU ZHENG (CN)
WU WUYONG (CN)
QU TONG (CN)
KANG PANPAN (CN)
ZHANG ZONGYUAN (CN)
HUANG WEIMING (CN)
LIU JIANYU (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2019/072666
Publication Date:
August 01, 2019
Filing Date:
January 22, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D309/10; A61K31/351; A61P3/10
Domestic Patent References:
WO2010095768A12010-08-26
WO2007136116A22007-11-29
WO2010095768A12010-08-26
WO2007136116A22007-11-29
WO2012023582A12012-02-23
WO2006035967A12006-04-06
Foreign References:
CN107519161A2017-12-29
US20110218159A12011-09-08
US20110218159A12011-09-08
CN107519161A2017-12-29
US20110218159A12011-09-08
Other References:
MORIYA, R. ET AL., AM JPHYSIOL ENDORINOL METAB, vol. 297, 2009, pages E1358 - E1365
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
ZHANG, S. ET AL., DRUG DISCOVERY TODAY, vol. 12, no. 9/10, 2007, pages 373 - 381
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
ROCHE ET AL.: "Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", J. MED. CHEM., vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
BERGE ET AL., J. PHARMACOL SCI, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JOHANNSSON ET AL., J. CLIN. ENDOCRINOL. METAB., vol. 82, 1997, pages 727 - 734
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
See also references of EP 3743412A4
Download PDF: