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Title:
GLUCOSE COMPOUND, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/057605
Kind Code:
A3
Abstract:
Disclosed are a glucose compound, a pharmaceutical composition, and an application thereof. The present invention provides the glucose compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, which has almost no activity of inhibiting cancer cell proliferation in vitro, shows a good anti-cancer effect in activity tests in vivo, has a good inhibitory effect on tumour metastasis, and has good market application prospects.

Inventors:
HUI YONGZHENG (CN)
XU ZUSHENG (CN)
MA XINGQUAN (CN)
XU LINLIN (CN)
LIANG XI (CN)
YANG ZHIQI (CN)
Application Number:
PCT/CN2019/106688
Publication Date:
May 07, 2020
Filing Date:
September 19, 2019
Export Citation:
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Assignee:
XDCEXPLORER SHANGHAI CO LTD (CN)
SHANGHAI GLYCODRUG PROMOTION CENTER (CN)
International Classes:
C07H15/00; A61K31/7042; A61P35/00
Foreign References:
US6489302B12002-12-03
Other References:
ZHANG, PENG . ET AL.: "Monosaccharide Analogues of Anticancer Peptide R-Lycosin-I: Role of Monosaccharide Conjugation in Complexation and the Potential of Lung Cancer Targeting and Therapy.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. 17, 5 July 2019 (2019-07-05), pages 7857 - 7873, XP055698470, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00634
DATABASE STN 16 July 2018 (2018-07-16), ANONYMOUS, XP009520711, retrieved from REGISTRY Database accession no. 2230793-18-5
CALVARESI, EMILIA C. ET AL.: "Glucose Conjugation for the Specific Targeting and Treatment of Cancer.", CHEMICAL SCIENCE, vol. 4, no. 6, 1 June 2013 (2013-06-01), pages 1 - 30, XP055395433, ISSN: 2041-6520, DOI: 10.1039/c3sc22205e
KUMAR, PIYUSH ET AL.: "Design, Synthesis, and Preliminary Biological Evaluation of 6-O-Glucose−Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 13, 18 June 2012 (2012-06-18), pages 6033 - 6046, XP055698474, ISSN: 0022-2623, DOI: 10.1021/jm2017336
REINHARD, J. ET AL.: "Monosaccharide-Linked Inhibitors of O6-Methylguanine-DNA Methyltransferase (MGMT): Synthesis, Molecular Modeling, and Structure-Activity Relationships.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 24, 31 October 2001 (2001-10-31), pages 4050 - 4061, XP055698482, ISSN: 0022-2623, DOI: 10.1021/jm010006e
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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