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Title:
GLUTAMATE DERIVATIVES OR SALTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/118843
Kind Code:
A1
Abstract:
Glutamate derivatives represented by general formula (I) or salts thereof; pharmaceutical compositions containing these compounds; and CaSR agonists containing the compounds. In general formula (I), R1, R2, R3, R4 and R5 are each independently selected from among hydrogen, halogeno, hydroxyl, sulfo, carboxyl, a phosphonic acid group, and so on; R6 is selected from among hydrogen, hydroxyl, alkyl, and so on; X is methylene or an oxygen atom; and E is selected from among alkoxy, mercapto, and so on.

Inventors:
SUGIKI MASAYUKI (JP)
OKAMATSU TORU (JP)
Application Number:
PCT/JP2011/057932
Publication Date:
September 29, 2011
Filing Date:
March 23, 2011
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
SUGIKI MASAYUKI (JP)
OKAMATSU TORU (JP)
International Classes:
C07C309/51; A23L27/00; A23L27/22; A61K31/198; A61K31/223; A61P1/04; A61P1/12; A61P5/18; A61P43/00
Foreign References:
JPH0616558A1994-01-25
JPH0649069A1994-02-22
US20070027106A12007-02-01
Other References:
MATSUOKA HIROHARU ET AL.: "Antirheumatic Agents. III. Novel Methotrexate Derivatives Bearing an Indoline Ring and a Modified Ornithine or Glutamic Acid", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 45, no. 7, July 1997 (1997-07-01), pages 1146 - 1150
KRAUT LUDWIG ET AL.: "Isolation and synthesis of rufulamide, an oligopeptide analogue from Metzgeria rufula", PHYTOCHEMISTRY, vol. 45, no. 8, August 1997 (1997-08-01), pages 1621 - 1626, XP004293326
See also references of EP 2551262A4
None
Attorney, Agent or Firm:
TAKAHASHI, FUMIKO (JP)
Fumiko Takahashi (JP)
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Claims:



 
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