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Title:
GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/170046
Kind Code:
A1
Abstract:
Disclosed are glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I). The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.

Inventors:
SHAO CHANG (CN)
GE MEI (CN)
RUAN LINGAO (CN)
WEI WEI (CN)
XIA XING (CN)
RAO MIN (CN)
MENG QINGQIAN (CN)
LUO MINYU (CN)
Application Number:
PCT/CN2019/076826
Publication Date:
September 12, 2019
Filing Date:
March 04, 2019
Export Citation:
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Assignee:
SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO LTD (CN)
ZHEJIANG MEDICINE CO LTD (CN)
International Classes:
C07K9/00; A61K38/14; A61P31/04
Domestic Patent References:
WO2000039156A12000-07-06
WO2001083521A22001-11-08
WO2011019839A22011-02-17
Foreign References:
CN108409837A2018-08-17
CN101928331A2010-12-29
US6635618B22003-10-21
US6392012B12002-05-21
US5840684A1998-11-24
US8420592B22013-04-16
EP0435503A11991-07-03
CN101928331A2010-12-29
Other References:
BIOORG MED CHEM LETT, vol. 13, no. 23, 2003, pages 4165 - 4168
CURR MED CHEM, vol. 8, no. 14, 2001, pages 1759 - 1773
EXPERT OPIN INVEST DRUGS, vol. 16, no. 3, 2007, pages 347 - 357
T. W. GREENEG. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
See also references of EP 3763728A4
Attorney, Agent or Firm:
SHANGHAI HUAGONG PATENT AGENCY (CN)
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