GLYCOPEPTIDES BASED DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2018/010476

A1

Provided are a glycopeptides based derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof. R1 is H, 2-alkylamine-ethyl group, a substituted benzyl group, a substituted phenylpropionyl group or a linear acyl group containing a carbon-carbon double bond, the benzene ring of said benzyl or phenylpropionyl bearing a halogen, a hydroxyl group, an amino group, a dimethylamino group, a trifluoromethyl group, or bearing a benzene ring that is substituted by a halogen atom, a hydroxyl group, or a trifluoromethyl group; the linear acyl group containing 1 to 6 carbon-carbon double bonds; R2 is a C1 to C5 linear amine group, and the terminal of the C1 to C5 linear amine group may bear a dimethylamino group or a substituted phenyl group, the benzene ring of the substituted phenyl group bearing a halogen or a cyano group or a nitro group. The compound of the formula (I) has good antibacterial activity and an enhanced antibacterial property against the glycopeptides based antibiotic resistant bacterium.

SHAO CHANG (CN)
RUAN LINGAO (CN)
WEI WEI (CN)
GE MEI (CN)
XIA XING (CN)
MENG QINGQIAN (CN)
ZHANG YUN (CN)
RAO MIN (CN)

PCT/CN2017/083551

January 18, 2018

May 09, 2017

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SHANGHAI LAIYI CENTER FOR BIOPHARMACEUTICAL R&D CO LTD (CN)
ZHEJIANG MED XINCHANG PHARM (CN)

C07K7/06; A61K38/08; A61K38/14; A61P31/04; C07K1/113; C07K9/00

WO2010048340A2

2010-04-29

CN101928331A	2010-12-29
CN101959849A	2011-01-26
CN101222933A	2008-07-16
CN87106483A	1988-06-08

SHANGHAI HUAGONG PATENT AGENCY (CN)

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