GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF

Title:

GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2002/068439

Kind Code:

A1

Abstract:

Glucopyranosyloxypyrazole derivatives represented by the following general formula (I) expressing an excellent human SGLT2 activity inhibitory effect and thus being useful as preventives or remedies for diseases caused by hyperglycemia such as diabetes, diabetic complications and obesity, pharmacologically acceptable salts thereof, prodrugs thereof, production intermediates thereof and medicinal use of the same: (I) wherein one of Q and T represents a group represented by the following general formula: while the other represents lower alkyl or lower haloalkyl; R?1¿ represents hydrogen, optionally substituted lower alkyl, lower alkenyl, cyclic lower alkyl, etc.; and R?2¿ represents hydrogen, optionally substituted lower alkyl, lower alkoxy, lower alkenyl, cyclic lower alkyl, cyclic lower alkoxy, etc.

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Inventors:

NISHIMURA TOSHIHIRO (JP)
FUSHIMI NOBUHIKO (JP)
FUJIKURA HIDEKI (JP)
KATSUNO KENJI (JP)
KOMATSU YOSHIMITSU (JP)
ISAJI MASAYUKI (JP)

Application Number:

PCT/JP2002/001707

Publication Date:

September 06, 2002

Filing Date:

February 26, 2002

Export Citation:

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Assignee:

KISSEI PHARMACEUTICAL (JP)
NISHIMURA TOSHIHIRO (JP)
FUSHIMI NOBUHIKO (JP)
FUJIKURA HIDEKI (JP)
KATSUNO KENJI (JP)
KOMATSU YOSHIMITSU (JP)
ISAJI MASAYUKI (JP)

International Classes:

A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07D233/70; C07H15/203; C07H17/02; (IPC1-7): C07H17/02; A61K31/7056; A61K31/706; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07D233/70; C07D401/10; C07D417/10

Domestic Patent References:

WO2001016147A1

2001-03-08

Foreign References:

US5264451A	1993-11-23
JPH04234851A	1992-08-24
EP0598359A1	1994-05-25

Other References:

KENNETH L. KEES ET AL.: "New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substitutedbenzyl)(trifluoromethyl)pyrazoles and -pyrazolones", J. MED. CHEM., vol. 39, no. 20, 1996, pages 3920 - 3928, XP002908218
See also references of EP 1364957A4

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