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Title:
GLYCOSYL-DERIVATIVES OF PUERARIN, PHARMACEUTICAL COMPOSITON, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/045755
Kind Code:
A1
Abstract:
Glycosyl-derivatives of puerarin presented by formula (I) or pharmaceutically acceptable salts thereof, wherein R is monosaccharides (6-carbon saccharides or 5-carbon saccharides) or oligosaccharyl (2-5 glycosyl selected from 6-carbon saccharides or 5-carbon saccharides); the pharmaceutically acceptable salts is inorganic or organic base addition salts. The glycosyl-derivatives of puerarin in the present invention or pharmaceutically acceptable salts thereof maintain higher stability and solubility, improve bioavailability and enhance therapeutic effect compared with puerarin.

Inventors:
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
Application Number:
PCT/CN2008/001799
Publication Date:
April 29, 2010
Filing Date:
October 24, 2008
Export Citation:
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Assignee:
UNIV NANJING NORMAL (CN)
ZHEJIANG TRADITIONAL CHINESE M (CN)
UNIV CHINA PHARMA (CN)
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
International Classes:
C07H17/07; A61K9/00; A61K9/02; A61K9/06; A61K9/08; A61K9/12; A61K9/19; A61K9/20; A61K9/22; A61K9/48; A61K9/52; A61K31/7048; A61P3/06; A61P3/10; A61P9/10; A61P13/12; A61P19/10; C12P19/60; C12R1/01
Foreign References:
CN101161325A2008-04-16
CN101147754A2008-03-26
KR20050076450A2005-07-26
Other References:
JIE-RONG JIANG ET AL.: "Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties.", APPL MICROBIOL BIOTECHNOL 2008., vol. 81., 2008, pages 647 - 657
YAO DAN ET AL.: "Discussions in pharmacological action and the development in clinical application of puerarin.", CHIN J CLIN PHAMACOL THER (CHINESE)., vol. 13, no. 4, April 2008 (2008-04-01), pages 468 - 474
FANG WEIQIN.: "The Study on Synthesis of Physiological Active Isofavonoids and Isoflavone-7-O-glucosides.", CHINESE MASTER'S THESES FULL-TEXT DATABASE ENGINEERING SCIENCE AND TECHNOLOGY I (CHINESE). 2007, vol. 5, 15 November 2007 (2007-11-15), pages B016 - 341
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE (ZexiongRoom 0501-0503 Bldg.,No. 1 GT International Center, Jia 3,Yongandongli, Chaoyang District, Beijing 2, CN)
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