Title:
GLYCOSYL-DERIVATIVES OF PUERARIN, PHARMACEUTICAL COMPOSITON, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/045755
Kind Code:
A1
Abstract:
Glycosyl-derivatives of puerarin presented by formula (I) or pharmaceutically acceptable salts thereof, wherein R is monosaccharides (6-carbon saccharides or 5-carbon saccharides) or oligosaccharyl (2-5 glycosyl selected from 6-carbon saccharides or 5-carbon saccharides); the pharmaceutically acceptable salts is inorganic or organic base addition salts. The glycosyl-derivatives of puerarin in the present invention or pharmaceutically acceptable salts thereof maintain higher stability and solubility, improve bioavailability and enhance therapeutic effect compared with puerarin.
Inventors:
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
Application Number:
PCT/CN2008/001799
Publication Date:
April 29, 2010
Filing Date:
October 24, 2008
Export Citation:
Assignee:
UNIV NANJING NORMAL (CN)
ZHEJIANG TRADITIONAL CHINESE M (CN)
UNIV CHINA PHARMA (CN)
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
ZHEJIANG TRADITIONAL CHINESE M (CN)
UNIV CHINA PHARMA (CN)
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
International Classes:
C07H17/07; A61K9/00; A61K9/02; A61K9/06; A61K9/08; A61K9/12; A61K9/19; A61K9/20; A61K9/22; A61K9/48; A61K9/52; A61K31/7048; A61P3/06; A61P3/10; A61P9/10; A61P13/12; A61P19/10; C12P19/60; C12R1/01
Foreign References:
CN101161325A | 2008-04-16 | |||
CN101147754A | 2008-03-26 | |||
KR20050076450A | 2005-07-26 |
Other References:
JIE-RONG JIANG ET AL.: "Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties.", APPL MICROBIOL BIOTECHNOL 2008., vol. 81., 2008, pages 647 - 657
YAO DAN ET AL.: "Discussions in pharmacological action and the development in clinical application of puerarin.", CHIN J CLIN PHAMACOL THER (CHINESE)., vol. 13, no. 4, April 2008 (2008-04-01), pages 468 - 474
FANG WEIQIN.: "The Study on Synthesis of Physiological Active Isofavonoids and Isoflavone-7-O-glucosides.", CHINESE MASTER'S THESES FULL-TEXT DATABASE ENGINEERING SCIENCE AND TECHNOLOGY I (CHINESE). 2007, vol. 5, 15 November 2007 (2007-11-15), pages B016 - 341
YAO DAN ET AL.: "Discussions in pharmacological action and the development in clinical application of puerarin.", CHIN J CLIN PHAMACOL THER (CHINESE)., vol. 13, no. 4, April 2008 (2008-04-01), pages 468 - 474
FANG WEIQIN.: "The Study on Synthesis of Physiological Active Isofavonoids and Isoflavone-7-O-glucosides.", CHINESE MASTER'S THESES FULL-TEXT DATABASE ENGINEERING SCIENCE AND TECHNOLOGY I (CHINESE). 2007, vol. 5, 15 November 2007 (2007-11-15), pages B016 - 341
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE (ZexiongRoom 0501-0503 Bldg.,No. 1 GT International Center, Jia 3,Yongandongli, Chaoyang District, Beijing 2, CN)
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