Title:
GLYCOSYL-DERIVATIVES OF PUERARIN, PHARMACEUTICAL COMPOSITON, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/045755
Kind Code:
A8
Abstract:
Glycosyl-derivatives of puerarin presented by formula (I) or pharmaceutically acceptable salts thereof, wherein R is monosaccharides (6-carbon saccharides or 5-carbon saccharides) or oligosaccharyl (2-5 glycosyl selected from 6-carbon saccharides or 5-carbon saccharides); the pharmaceutically acceptable salts is inorganic or organic base addition salts. The glycosyl-derivatives of puerarin in the present invention or pharmaceutically acceptable salts thereof maintain higher stability and solubility, improve bioavailability and enhance therapeutic effect compared with puerarin.
Inventors:
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
Application Number:
PCT/CN2008/001799
Publication Date:
July 15, 2010
Filing Date:
October 24, 2008
Export Citation:
Assignee:
UNIV NANJING NORMAL (CN)
ZHEJIANG TRADITIONAL CHINESE M (CN)
UNIV CHINA PHARMA (CN)
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
ZHEJIANG TRADITIONAL CHINESE M (CN)
UNIV CHINA PHARMA (CN)
DING XUANSHENG (CN)
CONG XIAODONG (CN)
YUAN SHENG (CN)
XU HAIDONG (CN)
YU CIGANG (CN)
ZHANG YUN (CN)
International Classes:
C07H17/07; A61K9/00; A61K9/02; A61K9/06; A61K9/08; A61K9/12; A61K9/19; A61K9/20; A61K9/22; A61K9/48; A61K9/52; A61K31/7048; A61P3/06; A61P3/10; A61P9/10; A61P13/12; A61P19/10; C12P19/60; C12R1/01
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE (ZexiongRoom 0501-0503 Bldg.,No. 1 GT International Center, Jia 3,Yongandongli, Chaoyang District, Beijing 2, CN)
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