GRANULES AND PREPARATION USING SAME

Title:

GRANULES AND PREPARATION USING SAME

Document Type and Number:

WIPO Patent Application WO/2021/182469

Kind Code:

A1

Abstract:

An embodiment of the present invention provides granules with a high content of active pharmaceutical ingredient and with a high degree of grain size homogeneity. Another embodiment of the present invention provides a preparation containing granules with high content of active pharmaceutical ingredient and with a high degree of grain size homogeneity. Another embodiment of the present invention provides granules containing: a core substance, a melt component layer disposed on the surface of the core substance, and an active pharmaceutical ingredient-containing layer disposed on the surface of the melt component layer, wherein the melt component layer contains a first melt component, and the active pharmaceutical ingredient-containing layer contains an active pharmaceutical ingredient and a second melt component or a polymer exhibiting compatibility with the first melt component.

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Inventors:

YOSHIHARA NAOKI (JP)
HASHIMOTO SHOTA (JP)
KIMATA RYOTA (JP)

Application Number:

PCT/JP2021/009297

Publication Date:

September 16, 2021

Filing Date:

March 09, 2021

Export Citation:

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Assignee:

SAWAI SEIYAKU KK (JP)

International Classes:

A61K9/16; A61K47/10; A61K47/12; A61K47/14; A61K47/32; A61K47/38

Foreign References:

JPH06256169A	1994-09-13
JPH04217913A	1992-08-07
JP2015199721A	2015-11-12
JP2017001999A	2017-01-05
JP2000084927A	2000-03-28
JP2015071542A	2015-04-16
JP2005075826A	2005-03-24
JP2004323409A	2004-11-18
JP2017001999A	2017-01-05
JP2015199721A	2015-11-12
JP2015071542A	2015-04-16
JPH06256169A	1994-09-13

Other References:

CHEM. PHARM. BULL., vol. 65, 2017, pages 726 - 731
See also references of EP 4119130A4

Attorney, Agent or Firm:

TAKAHASHI, HAYASHI AND PARTNER PATENT ATTORNEYS, INC. (JP)

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