Title:
GUANIDINOBENZOIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/039187
Kind Code:
A1
Abstract:
[Problem] To provide a compound useful as a renal disease preventive and/or therapeutic agent. [Solution] The inventors of the present invention investigated compounds having a trypsin inhibitory activity, verified that a guanidinobenzoic acid compound has a trypsin inhibitory activity, and achieved the present invention. This guanidinobenzoic acid compound can be used as: a renal disease preventive and/or therapeutic agent that serves as a substitute drug in a low-protein diet regimen; and a preventive and/or therapeutic agent against diseases to which trypsin contributes such as pancreatitis, reflux esophagitis, hepatic encephalopathy, and influenza.
Inventors:
FUJIYASU JIRO (JP)
OHNE KAZUHIKO (JP)
YAMAKI SUSUMU (JP)
IMAIZUMI TOMOYOSHI (JP)
HONDO TAKESHI (JP)
MATSUURA KEISUKE (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
OHNE KAZUHIKO (JP)
YAMAKI SUSUMU (JP)
IMAIZUMI TOMOYOSHI (JP)
HONDO TAKESHI (JP)
MATSUURA KEISUKE (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
Application Number:
PCT/JP2012/073576
Publication Date:
March 21, 2013
Filing Date:
September 14, 2012
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
FUJIYASU JIRO (JP)
OHNE KAZUHIKO (JP)
YAMAKI SUSUMU (JP)
IMAIZUMI TOMOYOSHI (JP)
HONDO TAKESHI (JP)
MATSUURA KEISUKE (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
FUJIYASU JIRO (JP)
OHNE KAZUHIKO (JP)
YAMAKI SUSUMU (JP)
IMAIZUMI TOMOYOSHI (JP)
HONDO TAKESHI (JP)
MATSUURA KEISUKE (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
International Classes:
C07C279/18; A61K31/404; A61P13/12; A61P43/00; C07C307/10; C07D207/16; C07D209/20; C07D209/42; C07D211/62; C07D213/79; C07D215/20; C07D215/48; C07D215/50; C07D233/64; C07D257/04; C07D271/06; C07D277/20; C07D277/56; C07D295/12; C07D333/38; C07D333/40; A61K31/155; A61K31/245; A61K31/381; A61K31/401; A61K31/405; A61K31/4172; A61K31/4245; A61K31/426; A61K31/44; A61K31/445; A61K31/4453; A61K31/47; A61K31/5375
Domestic Patent References:
| WO1994013631A1 | 1994-06-23 | |||
| WO1991018869A1 | 1991-12-12 | |||
| WO2011071048A1 | 2011-06-16 | |||
| WO1997037969A1 | 1997-10-16 |
Foreign References:
| JPH10306025A | 1998-11-17 | |||
| JPH06192085A | 1994-07-12 | |||
| JPH09124571A | 1997-05-13 | |||
| JPH08109164A | 1996-04-30 | |||
| JPH05286922A | 1993-11-02 | |||
| JPS5289640A | 1977-07-27 | |||
| JPS5753454A | 1982-03-30 | |||
| JPH0753500A | 1995-02-28 | |||
| JPH0848664A | 1996-02-20 | |||
| JPH09124571A | 1997-05-13 |
Other References:
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 321, no. 26, 1989, pages 1773 - 1777
THE LARICET, vol. 337, no. 8753, 1991, pages 1299 - 1304
AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 41, no. 3, 2003, pages S31 - S34
"Evidence-Based CKD Guidelines 2009", JAPAN SOCIETY OF NEPHROLOGY, 2009, pages 40 - 49
NEPHRON, vol. 74, no. 4, 1996, pages 709 - 712
ANTIVIRAL RESEARCH, vol. 92, no. 1, 2011, pages 27 - 36
"Protease Groups of Individuals which Determine Susceptibility to Infection of Influenza Virus and Pathogenesis of Influenza-Associated Encephalopathy", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 122, 2003, pages 45 - 53
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis 4th edition", 2006
TETRAHEDRON LETTERS, vol. 34, no. 21, 1993, pages 3389 - 3392
JOURNAL OF THE CHEMICAL SOCIETY. CHEMICAL COMMUNICATIONS, vol. 24, 1979, pages 1180 - 1181
A. R. KATRITZKY; R. J. K. TAYLOR: "Comprehensive Organic Functional Group Transformations II", vol. 2, 2005, ELSEVIER PERGAMON
THE CHEMICAL SOCIETY OF JAPAN: "Courses in Experimental Chemistry (5h Ed.)", vol. 14, 2005, MARUZEN
See also references of EP 2757093A4
THE LARICET, vol. 337, no. 8753, 1991, pages 1299 - 1304
AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 41, no. 3, 2003, pages S31 - S34
"Evidence-Based CKD Guidelines 2009", JAPAN SOCIETY OF NEPHROLOGY, 2009, pages 40 - 49
NEPHRON, vol. 74, no. 4, 1996, pages 709 - 712
ANTIVIRAL RESEARCH, vol. 92, no. 1, 2011, pages 27 - 36
"Protease Groups of Individuals which Determine Susceptibility to Infection of Influenza Virus and Pathogenesis of Influenza-Associated Encephalopathy", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 122, 2003, pages 45 - 53
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis 4th edition", 2006
TETRAHEDRON LETTERS, vol. 34, no. 21, 1993, pages 3389 - 3392
JOURNAL OF THE CHEMICAL SOCIETY. CHEMICAL COMMUNICATIONS, vol. 24, 1979, pages 1180 - 1181
A. R. KATRITZKY; R. J. K. TAYLOR: "Comprehensive Organic Functional Group Transformations II", vol. 2, 2005, ELSEVIER PERGAMON
THE CHEMICAL SOCIETY OF JAPAN: "Courses in Experimental Chemistry (5h Ed.)", vol. 14, 2005, MARUZEN
See also references of EP 2757093A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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