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Title:
HALOGENATED beta-LACTAM COMPOUND AND PRODUCTION OF 3-HYDROXYCEPHEM DERIVATIVE THEREFROM
Document Type and Number:
WIPO Patent Application WO/1992/016532
Kind Code:
A1
Abstract:
A halogenated beta-lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R1 represents optionally protected amino; R2 represents hydrogen or a carboxyl blocking group; R3 represents hydrogen or a hydroxyl blocking group; and X represents halogen. A process for producing a 3-hydroxycephem derivative is represented by general formula (I) in an industrially advantageous manner by reducing the compound (III) either with a metallic reducing agent or electrolytically. In formula (I), R1, R2 and R3 are as defined above.

Inventors:
TORII SHIGERU (JP)
TANAKA HIDEO (JP)
TANIGUCHI MASATOSHI (JP)
SASAOKA MITIO (JP)
SHIROI TAKASHI (JP)
KAMEYAMA YUTAKA (JP)
KIKUCHI RYO (JP)
Application Number:
PCT/JP1992/000126
Publication Date:
October 01, 1992
Filing Date:
February 10, 1992
Export Citation:
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Assignee:
OTSUKA KAGAKU KK (JP)
International Classes:
C07D205/095; C07D501/00; C07D501/08; C07D501/18; C07D501/59; C25B3/02; C25B3/04; (IPC1-7): C07D205/08; C07D501/08; C07D501/59; C25B3/04
Foreign References:
JPH03255066A1991-11-13
JPS5257188A1977-05-11
JPS51105051A1976-09-17
JPS51105088A1976-09-17
JPS5257162A1977-05-11
JPS50129590A1975-10-13
Other References:
Chem. Lett., No. 10, 1990, P. 1867-8.
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