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Patent Searching and Data


Title:
HAPLOTYPES OF THE ALDH5 GENE
Document Type and Number:
WIPO Patent Application WO2001092279
Kind Code:
A3
Abstract:
Novel genetic variants of the Aldehyde Dehydrogenase 5 (ALDH5) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the ALDH5 gene. Compositions and methods for haplotyping and/or genotyping the ALDH5 gene in an individual are also disclosed. Polynucleotides defined by the sequence of the haplotypes disclosed herein are also described.

Inventors:
DUDA AMY (IT)
FINKEL KEVIN (US)
KAZEMI AMIR (US)
MESSER CHAD (US)
SANCHIS ANGELA (US)
Application Number:
PCT/US2001/017253
Publication Date:
September 18, 2003
Filing Date:
May 29, 2001
Export Citation:
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Assignee:
GENAISSANCE PHARMACEUTICALS (US)
DUDA AMY (IT)
FINKEL KEVIN (US)
KAZEMI AMIR (US)
MESSER CHAD (US)
SANCHIS ANGELA (US)
International Classes:
C12Q1/68; C12Q1/6883; (IPC1-7): C12Q1/68
Other References:
HSU L.C. ET AL.: "Cloning and characterization of a new functional human aldehyde dehydrogenase gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 19, July 1991 (1991-07-01), pages 12257 - 12265, XP002963884
CHAMBLISS K.L. ET AL.: "Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutryric aciduria)", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 63, no. 2, 1998, pages 399 - 408, XP002963885
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