Title:
HEART-ON-CHIP DEVICE, AND CARDIAC FUNCTION EVALUATION METHOD, DRUG SCREENING METHOD AND CARDIAC TOXICITY EVALUATION TEST METHOD USING HEART-ON-CHIP DEVICE
Document Type and Number:
WIPO Patent Application WO/2021/090875
Kind Code:
A1
Abstract:
The present invention provides a heart-on-chip device provided with a microfluidic chip and a cardiac tissue sheet, wherein: the microfluidic chip comprises an oscillating section which is oscillatable in a definite direction, a flow channel in which a liquid flows due to the oscillation of the oscillating section, a diaphragm provided between the oscillating section and the flow channel, and a detection target dispersed in the liquid; and the cardiac tissue sheet, which contains cardiomyocytes, is in contact with the oscillating section in such a manner as to be able to oscillate the oscillating section.
Inventors:
MASUMOTO HIDETOSHI (JP)
TANAKA YO (JP)
ABULAITI MOSHA (JP)
YALIKUN YAXIAER (JP)
SATO ASAKO (JP)
MURATA KOZUE (JP)
KAWAHARA NORIYUKI (JP)
KATO KENSUKE (JP)
TANAKA YO (JP)
ABULAITI MOSHA (JP)
YALIKUN YAXIAER (JP)
SATO ASAKO (JP)
MURATA KOZUE (JP)
KAWAHARA NORIYUKI (JP)
KATO KENSUKE (JP)
Application Number:
PCT/JP2020/041334
Publication Date:
May 14, 2021
Filing Date:
November 05, 2020
Export Citation:
Assignee:
RIKEN (JP)
STEM CELL & DEVICE LABORATORY INC (JP)
STEM CELL & DEVICE LABORATORY INC (JP)
International Classes:
C12M1/34; C12Q1/02
Foreign References:
| CN108300660A | 2018-07-20 | |||
| US20180106782A1 | 2018-04-19 |
Other References:
LI LINJIE, CHEN ZHUOYUE, SHAO CHANGMIN, SUN LINGYU, SUN LINGYUN, ZHAO YUANJIN: "Graphene hybrid anisotropic structural color film for cardiomyocytes ' monitoring", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 3, 22 October 2019 (2019-10-22), pages 1 - 8, XP055821677, DOI: 10.1002/adfm.201906353
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. (JP)
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