Title:
HEART FAILURE PREVENTING AGENT
Document Type and Number:
WIPO Patent Application WO/2013/012049
Kind Code:
A1
Abstract:
Provided are a medicinal agent and a food product, both of which prevent heart diseases such as cardiomegaly and heart failure. Specifically provided is an agent for preventing a heart disease such selected from among heart failure, cardiac fibrosis, ventricular wall thickening and cardiomegaly, which comprises luteolin or a derivative thereof as an active ingredient.
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Inventors:
MORITA HIROYUKI (JP)
NAGAI RYOZO (JP)
NAKAYAMA ATSUKO (JP)
HASHIMOTO TADASHI (JP)
NAGAI RYOZO (JP)
NAKAYAMA ATSUKO (JP)
HASHIMOTO TADASHI (JP)
Application Number:
PCT/JP2012/068382
Publication Date:
January 24, 2013
Filing Date:
July 19, 2012
Export Citation:
Assignee:
UNIV TOKYO (JP)
THERAVALUES CORP (JP)
MORITA HIROYUKI (JP)
NAGAI RYOZO (JP)
NAKAYAMA ATSUKO (JP)
HASHIMOTO TADASHI (JP)
THERAVALUES CORP (JP)
MORITA HIROYUKI (JP)
NAGAI RYOZO (JP)
NAKAYAMA ATSUKO (JP)
HASHIMOTO TADASHI (JP)
International Classes:
A61K31/352; A61K31/7042; A61P9/00; A61P9/04; A23L1/30; C07D311/30; C07H17/07
Foreign References:
| JPH09143070A | 1997-06-03 | |||
| JPH1095732A | 1998-04-14 |
Other References:
GLORIA GUTIERREZ-VENEGAS, ET AL.: "The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes", INT. IMMUNOPHARMACOL., vol. 10, no. 9, September 2010 (2010-09-01), pages 1003 - 1009
MOLECULAR CARDIOVASCULAR MEDICINE, vol. 7, no. 6, 2006, pages 574 - 579
SYED HAQ, ET AL.: "Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure", CIRCULATION, vol. 103, 6 February 2001 (2001-02-06), pages 670 - 677
HIDEO A. BABA, ET AL.: "Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism", CARDIOVASCUL. RES., vol. 59, 2003, pages 390 - 399
A F E RUMP, ET AL.: "Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts", GEN. PHARMACOL., vol. 25, no. 6, October 1994 (1994-10-01), pages 1137 - 1142
NUTR. CARE, vol. 2, no. 6, 2009, pages 612 - 616
MING-JIUAN WU, ET AL.: "Antioxidant Activity of Glossogyne tenuifolia", J. AGRIC. FOOD CHEM., vol. 53, no. 16, 2005, pages 6305 - 6312
JUNG-SUK CHOI, ET AL.: "Flavones Mitigate Tumor Necrosis Factor-g-Induced Adhesion Molecule Upregulation in Cultured Human Endothelial Cells: Role of Nuclear Factor-kB", J. NUTR., vol. 134, 2004, pages 1013 - 1019
MOLECULAR CARDIOVASCULAR MEDICINE, vol. 8, no. 1, 2007, pages 22 - 26
MOLECULAR CARDIOVASCULAR MEDICINE, vol. 7, no. 6, 2006, pages 574 - 579
SYED HAQ, ET AL.: "Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure", CIRCULATION, vol. 103, 6 February 2001 (2001-02-06), pages 670 - 677
HIDEO A. BABA, ET AL.: "Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism", CARDIOVASCUL. RES., vol. 59, 2003, pages 390 - 399
A F E RUMP, ET AL.: "Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts", GEN. PHARMACOL., vol. 25, no. 6, October 1994 (1994-10-01), pages 1137 - 1142
NUTR. CARE, vol. 2, no. 6, 2009, pages 612 - 616
MING-JIUAN WU, ET AL.: "Antioxidant Activity of Glossogyne tenuifolia", J. AGRIC. FOOD CHEM., vol. 53, no. 16, 2005, pages 6305 - 6312
JUNG-SUK CHOI, ET AL.: "Flavones Mitigate Tumor Necrosis Factor-g-Induced Adhesion Molecule Upregulation in Cultured Human Endothelial Cells: Role of Nuclear Factor-kB", J. NUTR., vol. 134, 2004, pages 1013 - 1019
MOLECULAR CARDIOVASCULAR MEDICINE, vol. 8, no. 1, 2007, pages 22 - 26
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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