Title:
HEMOSTATIC COMPOSITION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/108670
Kind Code:
A3
Abstract:
Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.
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Inventors:
FAN JIE (CN)
YU LISHA (CN)
XIAO LIPING (CN)
CHEN HAO (CN)
SHANG XIAOQIANG (CN)
YU LISHA (CN)
XIAO LIPING (CN)
CHEN HAO (CN)
SHANG XIAOQIANG (CN)
Application Number:
PCT/CN2020/074061
Publication Date:
August 13, 2020
Filing Date:
January 28, 2020
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61L15/16; A61L15/18; A61L15/38; A61L33/02; A61L33/16
Foreign References:
| CN101104080A | 2008-01-16 | |||
| CN108785735A | 2018-11-13 | |||
| EP2543394A1 | 2013-01-09 | |||
| UA68506A | 2004-08-16 | |||
| US20020012692A1 | 2002-01-31 |
Other References:
LI, YUNLONG ET AL.: "In Situ Generated Thrombin in the Protein Corona of Zeolites: Relevance of the Functional Proteins to its Biological Impact", NANO RESEARCH, vol. 7, no. 10, 31 October 2014 (2014-10-31), XP035403006, DOI: 20200331154808Y
"Diagnosis of Blood Diseases", 31 March 1994, DALIAN PUBLISHING HOUSE, CN, ISBN: 7-80612-033-5, article WANG, YONGCAI: "Hemostatic Function of Platelet", pages: 1 - 17, XP009528717
"Diagnosis of Blood Diseases", 31 March 1994, DALIAN PUBLISHING HOUSE, CN, ISBN: 7-80612-033-5, article WANG, YONGCAI: "Hemostatic Function of Platelet", pages: 1 - 17, XP009528717
Attorney, Agent or Firm:
ZHEJIANG HANGZHOU JINTONG PATENT AGENCY CO., LTD (CN)
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