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Title:
HEPARANASE ACTIVITY INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/040496
Kind Code:
A1
Abstract:
A heparanase activity inhibitor comprising a cyclic carboxamide derivative represented by general formula (I) (wherein n represents an integer of 1 to 3; R1 represents a hydrogen atom, or a hydrocarbon group which has 1 to 6 carbon atoms and may be substituted by a hydroxy group; X represents a group represented by the formula -CH2- or -N(R2)-; and R2 represents a hydrogen atom, or a hydrocarbon group which has 1 to 6 carbon atoms and may be substituted by a hydroxy group) or a salt thereof as an active ingredient.

Inventors:
IRIYAMA SHUNSUKE (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
Application Number:
PCT/JP2010/066998
Publication Date:
April 07, 2011
Filing Date:
September 29, 2010
Export Citation:
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Assignee:
SHISEIDO CO LTD (JP)
IRIYAMA SHUNSUKE (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
International Classes:
A61K31/4015; A61K8/49; A61K31/4166; A61P43/00; A61Q19/08
Domestic Patent References:
WO2009122540A12009-10-08
WO2009123215A12009-10-08
WO2003084302A22003-10-16
Foreign References:
EP2119429A12009-11-18
JP2008303187A2008-12-18
JP2008303186A2008-12-18
JP2008303185A2008-12-18
JP2001163794A2001-06-19
JP2000503660A2000-03-28
JPH11335235A1999-12-07
JP2009056717W2009-03-31
DE2746550A11978-04-20
JP2901297B21999-06-07
JP2008303186A2008-12-18
JP2004526758A2004-09-02
JP2003502054A2003-01-21
Other References:
K. KAJIYA ET AL., AM. J. PATHOL., vol. 169, no. 4, 2006, pages 1496 - 1503
I. VLODAVSKY ET AL., SEMIN CANCER BIOL., vol. 12, no. 2, 2002, pages 121 - 129
Attorney, Agent or Firm:
AOKI Atsushi et al. (JP)
Aoki 篤 (JP)
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