Title:
HEPARIN NANO DRUG CARRIER SYSTEM FOR LOADING AMINO ANTI-TUMOR DRUG, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/203959
Kind Code:
A1
Abstract:
Disclosed in the present invention is a heparin nano drug carrier system for loading an amino anti-tumor drug. The drug carrier system is a conjugate for loading the amino anti-tumor drug on a PEGylated heparin molecule. A natural polysaccharide heparin that is biodegradable and has good compatibility and high availability is used as a drug carrier, and, by means of combining PEG modification and the amino anti-tumor drug, as compared with free drugs, nanoparticles have a significantly enhanced anti-tumor therapeutic index and biological safety in in-vivo therapy.
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Inventors:
LI FANGNIAN (CN)
SHI JIAN (CN)
TIAN SHANE XINXIN (CN)
SHI JIAN (CN)
TIAN SHANE XINXIN (CN)
Application Number:
PCT/CN2021/082331
Publication Date:
October 14, 2021
Filing Date:
March 23, 2021
Export Citation:
Assignee:
NANJING KING FRIEND BIOCHEMICAL PHARMACEUTICAL CO LTD (CN)
KINDOS PHARMACEUTICALS CO LTD (CN)
KINDOS PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K47/61; A61K31/454; A61K31/517; A61K31/704; A61K47/60; A61K47/69; A61P35/00
Foreign References:
| CN112121174A | 2020-12-25 | |||
| CN112121177A | 2020-12-25 | |||
| CN112402625A | 2021-02-26 | |||
| CN104307049A | 2015-01-28 | |||
| US20150140073A1 | 2015-05-21 |
Other References:
WU YAHUI; LI FANGNIAN; ZHANG XIAOQIN; LI ZHIQIAN; ZHANG QIANFENG; WANG WENJIA; PAN DAYI; ZHENG XIULI; GU ZHONGWEI; ZHANG HU; GONG : "Tumor microenvironment-responsive PEGylated heparin-pyropheophorbide-a nanoconjugates for photodynamic therapy", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS , LTD BARKING, GB, vol. 255, 13 December 2020 (2020-12-13), GB , XP086440945, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2020.117490
WANG YING, WANG YIQING, XIANG JIANNAN, YAO KAITAI: "Target-Specific Cellular Uptake of Taxol-Loaded Heparin-PEG-Folate Nanoparticles", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 11, no. 12, 13 December 2010 (2010-12-13), US , pages 3531 - 3538, XP055856809, ISSN: 1525-7797, DOI: 10.1021/bm101013s
CHOI WON IL, KIM MIHYE, TAE GIYOONG, KIM YOUNG HA: "Sustained Release of Human Growth Hormone from Heparin-Based Hydrogel", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 6, 1 June 2008 (2008-06-01), US , pages 1698 - 1704, XP055853268, ISSN: 1525-7797, DOI: 10.1021/bm701391b
WANG YING, WANG YIQING, XIANG JIANNAN, YAO KAITAI: "Target-Specific Cellular Uptake of Taxol-Loaded Heparin-PEG-Folate Nanoparticles", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 11, no. 12, 13 December 2010 (2010-12-13), US , pages 3531 - 3538, XP055856809, ISSN: 1525-7797, DOI: 10.1021/bm101013s
CHOI WON IL, KIM MIHYE, TAE GIYOONG, KIM YOUNG HA: "Sustained Release of Human Growth Hormone from Heparin-Based Hydrogel", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 6, 1 June 2008 (2008-06-01), US , pages 1698 - 1704, XP055853268, ISSN: 1525-7797, DOI: 10.1021/bm701391b
Attorney, Agent or Firm:
CHINABLE IP (CN)
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