HEPATITIS B VIRUS (HBV) INHIBITOR

WIPO Patent Application WO/2019/017814

A9

The present invention relates to novel hepatitis B virus (HBV) inhibitors for use as chemotherapeutic agents for treating HBV. The compounds bind to HBV core-antigen and trigger the formation of aberrant virus capsids not carrying the viral genome, which leads to the formation and secretion of defective (avirulent) virus particles. The HBV inhibitor is a compound of general formula 1 and formula 2, or an isotopically enriched analogue, pharmaceutically acceptable salt, hydrate or solvate thereof, in crystalline or polycrystalline form, wherein R is hydrogen or methyl and n = 1, 2 or 3.

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IVACHTCHENKO ALEXANDRE VASILIEVICH (US)
IVASHCHENKO ANDREY ALEXANDROVICH (RU)
SAVCHUK NIKOLAY FILIPPOVICH (US)
ROGOVOJ BORIS (US)
BYCHKO VADIM VASILIEVICH (US)

PCT/RU2018/000126

February 14, 2019

March 02, 2018

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IVACHTCHENKO ALEXANDRE VASILIEVICH (US)
IVASHCHENKO ANDREY ALEXANDROVICH (RU)
SAVCHUK NIKOLAY FILIPPOVICH (US)
IVACHTCHENKO ALENA ALEXANDROVNA (US)
ALLA CHEM LLC (US)

C07C311/43; A61K31/20; A61K31/4025; A61K31/454; A61K31/506; A61K31/55; A61K31/664; C07D401/12; C07D403/12; C07D411/04; C07F9/22

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