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Title:
HEPTOSE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2012/073214
Kind Code:
A3
Abstract:
Compounds having the general formula (I) pharmaceutical compositions containing them for use in inhibiting bacterial heptose biosynthesis and thereby lowering or suppressing bacterial virulence.

Inventors:
GERUSZ VINCENT (FR)
VINCENT STEPHANE (BE)
OXOBY MAYALEN (FR)
ATAMANYUK DMYTRO (FR)
MOREAU FRANCOIS (FR)
ANDALOUSSI MOUNIR (BE)
TIKAD ABDELLATIF (BE)
Application Number:
PCT/IB2011/055404
Publication Date:
August 30, 2012
Filing Date:
December 01, 2011
Export Citation:
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Assignee:
BIODIM LAB (FR)
GERUSZ VINCENT (FR)
VINCENT STEPHANE (BE)
OXOBY MAYALEN (FR)
ATAMANYUK DMYTRO (FR)
MOREAU FRANCOIS (FR)
ANDALOUSSI MOUNIR (BE)
TIKAD ABDELLATIF (BE)
International Classes:
C07H3/02; A61K31/351; A61K31/7004; A61K31/7024; A61K31/7028; A61P31/04; C07D309/10; C07H11/04; C07H15/04
Foreign References:
US5798343A1998-08-25
Other References:
GRZESZCZYK B ET AL: "Five monophosphates of methyl l-glycero-alpha-d-manno-heptopyranoside: synthesis, hydrolysis and migrations", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 307, no. 1-2, 1 February 1998 (1998-02-01), pages 55 - 67, XP004124722, ISSN: 0008-6215, DOI: 10.1016/S0008-6215(98)00037-8
JAIPURI, A. FIROZ ET AL: "Synthesis and Quantitative Evaluation of Glycero-D-manno-heptose Binding to Concanavalin A by Fluorous-Tag Assistance", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH), vol. 120, no. 9, 15 February 2008 (2008-02-15), pages 1731 - 1734, XP055021646, ISSN: 0044-8249, DOI: 10.1002/ange.200704262
STEWART A ET AL: "Studies of alkaline mediated phosphate migration in synthetic phosphoethanolamine l-glycero-d-manno-heptoside derivatives", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 313, no. 3-4, 15 December 1998 (1998-12-15), pages 193 - 202, XP004163062, ISSN: 0008-6215, DOI: 10.1016/S0008-6215(98)00271-7
KOSMA PAUL ET AL: "Synthesis of inner core antigens related to Chlamydia, Pseudomonas and Acinetobacter LPS", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 5, no. 3, 1 January 1999 (1999-01-01), pages 157 - 163, XP009157381, ISSN: 0968-0519, DOI: 10.1177/09680519990050031001
PAULSEN H ET AL: "Synthese von DD-Heptosephosphaten als Substrate oder potentielle Inhibitoren fuer die Heptose-Synthetase", LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH. WEINHEIM, DE, 1 January 1994 (1994-01-01), pages 389 - 397, XP002135530, ISSN: 0170-2041
MAXIME DURKA ET AL: "Systematic Synthesis of Inhibitors of the Two First Enzymes of the Bacterial Heptose Biosynthetic Pathway: Towards Antivirulence Molecules Targeting Lipopolysaccharide Biosynthesis", CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 40, 26 August 2011 (2011-08-26), pages 11305 - 11313, XP055020620, ISSN: 0947-6539, DOI: 10.1002/chem.201100396
Attorney, Agent or Firm:
HIRSCH & ASSOCIES (Paris, Paris, FR)
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