HETEROARYLPIPERIDINE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

HETEROARYLPIPERIDINE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/166980

Kind Code:

A1

Abstract:

The present invention belongs to the field of medicine, and in particular relates to a heteroarylpiperidine derivative, a pharmaceutical composition and use thereof. The heteroarypiperidine derivative as shown in formula (I) provided by the present invention can be prepared into oral formulations, and has good pharmacokinetic properties.

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Inventors:

ZU HOUXIAN (CN)
WANG YIQIAN (CN)
DU GUOLONG (CN)
CHEN KAI (CN)
XU XIAOFENG (CN)
LIU XIANGYONG (CN)
DING LIEMING (CN)
WANG JIABING (CN)

Application Number:

PCT/CN2022/075486

Publication Date:

August 11, 2022

Filing Date:

February 08, 2022

Export Citation:

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Assignee:

BETTA PHARMACEUTICALS CO LTD (CN)

International Classes:

C07D471/04; A61K31/47; A61P35/00

Domestic Patent References:

WO2019002441A1	2019-01-03
WO2019002442A1	2019-01-03
WO2019228443A1	2019-12-05

Foreign References:

CN109843888A	2019-06-04
US20170320871A1	2017-11-09
US20170305909A1	2017-10-26

Other References:

SCOTT JAMES S., MOSS THOMAS A., BALAZS AMBER, BARLAAM BERNARD, BREED JASON, CARBAJO RODRIGO J., CHIARPARIN ELISABETTA, DAVEY PAUL : "Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 23, 10 December 2020 (2020-12-10), US , pages 14530 - 14559, XP055823030, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01163
SCOTT JAMES S., MOSS THOMAS A., BARLAAM BERNARD, DAVEY PAUL R. J., FAIRLEY GARY, GANGL ERIC T., GREENWOOD RYAN D. R., HATOUM-MOKDA: "Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833", ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 12, 10 December 2020 (2020-12-10), US , pages 2519 - 2525, XP055957319, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.0c00505

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