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Patent Searching and Data


Title:
HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/052843
Kind Code:
A1
Abstract:
Disclosed is a FXR inhibitor comprising a compound represented by the formula (I') or a salt or a prodrug of the compound or salt: wherein each symbol is as defined in the description. The FXR inhibitor has an excellent FXR-inhibiting effect, can significantly decrease the blood LDL-cholesterol level or the blood non-HDL-cholesterol level, and exerts an effect of decreasing the triglyceride level, an effect of increasing the HDL-cholesterol level and an effect of promoting the excretion of bile acid into the feces.

Inventors:
MIURA SHOTARO (JP)
SHIMADA MITSUYUKI (JP)
MARUI SHOGO (JP)
TAMURA NORIKAZU (JP)
NAKADA YOSHIHISA (JP)
TOZAWA RYUICHI (JP)
SAKAMOTO JUNICHI (JP)
FUNABASHI YASUNORI (JP)
HOSONO HIROSHI (JP)
Application Number:
PCT/JP2006/322420
Publication Date:
May 10, 2007
Filing Date:
November 02, 2006
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL (JP)
MIURA SHOTARO (JP)
SHIMADA MITSUYUKI (JP)
MARUI SHOGO (JP)
TAMURA NORIKAZU (JP)
NAKADA YOSHIHISA (JP)
TOZAWA RYUICHI (JP)
SAKAMOTO JUNICHI (JP)
FUNABASHI YASUNORI (JP)
HOSONO HIROSHI (JP)
International Classes:
C07D207/34; A61K31/381; A61K31/40; A61K31/415; A61K31/4155; A61K31/4178; A61K31/4184; A61K31/42; A61K31/422; A61K31/4245; A61K31/427; A61K31/454; A61K31/4709; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/553; A61P3/06; A61P9/10; A61P43/00; C07D213/81; C07D213/82; C07D231/14; C07D233/90; C07D239/28; C07D261/18; C07D263/34; C07D277/20; C07D277/56; C07D307/68; C07D333/38; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D409/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D487/04; C07D498/04
Domestic Patent References:
WO2003015771A12003-02-27
WO2005037199A22005-04-28
WO2000047558A12000-08-17
WO2004043951A12004-05-27
WO2004099156A12004-11-18
WO2005073165A12005-08-11
WO2005021486A12005-03-10
WO2005051949A12005-06-09
Foreign References:
JP2005035966A2005-02-10
JP2005507932A2005-03-24
JP2003528070A2003-09-24
JP2005510564A2005-04-21
US5776954A1998-07-07
JPH04507422A1992-12-24
JP2002529455A2002-09-10
Other References:
BRATENKO M.K. ET AL.: "4-Functionally substituted 3-heterylpyrazoles: III. 3-Aryl(heteryl)pyrazole-4-carboxylic acids and their derivatives", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 37, no. 4, 2001, pages 552 - 555, XP002332303
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Osaka Midosuji Bldg. 1-1, Fushimimachi, 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
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