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Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/106975
Kind Code:
A1
Abstract:
The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I) (in the formula, each symbol is as described in the specification) or a salt thereof has orexin type 2 receptor agonist activity and is useful as an agent for the prevention or treatment of narcolepsy.

Inventors:
ITO YOSHITERU (JP)
MIYANOHANA YUHEI (JP)
KAJITA YUICHI (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
KOIKE TATSUKI (JP)
TOKUNAGA NORIHITO (JP)
KIMURA EIJI (JP)
PAWLICZEK ALEXANDER MARTIN (JP)
PIRA MARILENA (JP)
MIGUELEZ-RAMOS JAVIER (JP)
Application Number:
PCT/JP2020/043924
Publication Date:
June 03, 2021
Filing Date:
November 26, 2020
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61P3/04; A61K31/4375; A61K31/444; A61P5/50; A61P9/04; A61P19/08; A61P23/00; A61P25/16; A61P25/20; A61P25/26; A61P25/28; A61P43/00; C07D455/02; C07D471/04
Domestic Patent References:
WO2019027003A12019-02-07
WO2016199906A12016-12-15
WO2020122092A12020-06-18
WO2015073707A12015-05-21
WO2015048091A12015-04-02
WO2015147240A12015-10-01
WO2012137982A92013-02-14
WO2017135306A12017-08-10
WO2018164191A12018-09-13
WO2018164192A12018-09-13
WO2019027003A12019-02-07
WO2019027058A12019-02-07
WO2020004536A12020-01-02
WO2020004537A12020-01-02
WO2020122092A12020-06-18
WO2020122093A12020-06-18
WO2020158958A12020-08-06
WO2020167701A12020-08-20
WO2020167706A12020-08-20
WO2001000663A22001-01-04
Foreign References:
JP2019504098A2019-02-14
Other References:
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
HIDEO TOGO, KODANSHA, ORGANIC NAME REACTIONS, THE REACTION MECHANISM AND ESSENCE, vol. 14-15
KIYOSHI TOMIOKA, KAGAKUDOJIN, STRATEGIC APPLICATIONS OF NAMED REACTIONS IN ORGANIC SYNTHESIS, vol. I-VII
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed", 2004, THIEME
"IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", vol. 7, 1990, HIROKAWA SHOTEN, article "Design of Molecules", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
See also references of EP 4066893A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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