Title:
HETEROCYCLIC THR-β RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/032218
Kind Code:
A1
Abstract:
A chemical compound shown in formula (I) below and an isomer thereof or a pharmaceutically acceptable salt thereof. The compound improves THR-β agonistic activity while also improving selectivity for THR-α, thereby improving pharmaceutical quality.
Inventors:
YU SHANGHAI (CN)
LI BEN (CN)
LI BEN (CN)
Application Number:
PCT/CN2020/121801
Publication Date:
February 25, 2021
Filing Date:
October 19, 2020
Export Citation:
Assignee:
SUZHOU VINTAGENCE PHARMA CO LTD (CN)
International Classes:
C07F9/6574; A61K31/662; A61P1/16; A61P3/04; A61P3/06; C07F9/40
Domestic Patent References:
| WO2018053036A1 | 2018-03-22 | |||
| WO2006128058A2 | 2006-11-30 | |||
| WO2011038207A1 | 2011-03-31 | |||
| WO2014183462A1 | 2014-11-20 | |||
| WO2003094845A2 | 2003-11-20 | |||
| WO2007009913A1 | 2007-01-25 | |||
| WO2010122980A1 | 2010-10-28 | |||
| WO2011038207A1 | 2011-03-31 | |||
| WO2005051298A2 | 2005-06-09 | |||
| WO2006128058A2 | 2006-11-30 |
Foreign References:
| CN201910763932A | 2019-08-19 |
Other References:
See also references of EP 4019524A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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