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Patent Searching and Data


Title:
HIGH MOLECULAR WEIGHT COLLAGEN-LIKE PROTEIN POLYMERS
Document Type and Number:
WIPO Patent Application WO/1993/010154
Kind Code:
A1
Abstract:
Collagen-like polymers having repetitive triads are produced having reduced proline content, where glycine is the initial amino acid and the subsequent amino acids are varied, while retaining at least a minimum percentage of prolines. The resulting polymers have collagen-like properties, but are capable of being produced in unicellular microorganisms at high molecular weights and in high efficiency. The polymers while retaining collagen-like characteristics, include various novel sequences which impart new characteristics, finding wide use in photographic, medical, structural and fiber applications.

Inventors:
CAPPELLO JOSEPH (US)
FERRARI FRANCO A (US)
Application Number:
PCT/US1992/009485
Publication Date:
May 27, 1993
Filing Date:
November 04, 1992
Export Citation:
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Assignee:
PROTEIN POLYMER TECH INC (US)
International Classes:
C07K14/78; C07K16/00; C08H1/00; C08H1/06; C12N1/19; A61L27/00; C12N1/21; C12N15/09; C12P21/02; D06M16/00; A61K38/00; C12R1/19; D06M101/00; D06M101/02; D06M101/10; G03C1/047; (IPC1-7): C07K15/00; C07K15/20; C12N1/00; C12N1/21; C12N15/12; C12P21/00
Domestic Patent References:
WO1988003533A11988-05-19
Other References:
Ann. N. Y. Acad. Sci., Volume 460, issued 30 December 1985, E.J. MILLER, "The Structure of Fibril-Forming Collagens", pages 1-13, especially page 4.
Gene, Volume 80, issued 1989, I. GOLDBERG et al., "Cloning and Expression of a Collagen-Analog-Encoding Synthetic Gene in Escherichia coli", pages 305-314, entire document.
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