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Title:
HIGH-PURITY FLUORESCEIN SODIUM
Document Type and Number:
WIPO Patent Application WO/2017/082430
Kind Code:
A1
Abstract:
Provided are a method for purifying fluorescein sodium, a method for producing substantially organic-solvent-free fluorescein sodium or high-purity fluorescein sodium, substantially organic-solvent-free fluorescein sodium or high-purity fluorescein sodium, and an ophthalmic diagnostic reagent that includes substantially organic-solvent-free fluorescein sodium or high-purity fluorescein sodium. A method for purifying fluorescein sodium, the method including adding 2-propanol or 2-butanol to an aqueous solution in which fluorescein sodium has been dissolved, and crystallizing the fluorescein sodium.

Inventors:
OHNO ATSUSHI (JP)
KAWASHIMA KENJI (JP)
YAMAMOTO NORIYOSHI (JP)
Application Number:
PCT/JP2016/083730
Publication Date:
May 18, 2017
Filing Date:
November 14, 2016
Export Citation:
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Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
C09B67/48; A61K49/00; C07D311/80; C07D493/10; C09B11/28
Domestic Patent References:
WO2008073764A22008-06-19
Foreign References:
CN101270124A2008-09-24
CN101628907A2010-01-20
US5055595A1991-10-08
Other References:
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI HANDBOOK, 2008, pages 17 - 23, 37 - 40, 45 - 51, 57 - 65
Attorney, Agent or Firm:
SHOBAYASHI, Masayuki et al. (JP)
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