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Title:
HIGH-RESOLUTION SPATIAL OMICS DETECTION METHOD FOR TISSUE SAMPLE
Document Type and Number:
WIPO Patent Application WO/2023/011628
Kind Code:
A1
Abstract:
A high-resolution spatial omics detection device, system, and method for a tissue sample. Provided are the high-resolution spatial omics detection device, system, and method for the tissue sample, respectively comprising: a slide having a micro-well reaction chamber array capable of accommodating a micro-carrier, a method for modifying nucleic acid molecule identifiers, and a method for reducing cross contamination of omics information in the process of capturing spatial omics information of the tissue sample. By using the spatial omics detection method, the resolution of spatial omics detection is remarkably improved, detection costs are reduced, and meanwhile, the cross contamination of spatial omics information is fundamentally reduced.

Inventors:
ZHANG JUNHU (CN)
LIANG CHONGYANG (CN)
YU NIANZUO (CN)
JIN ZHENGYANG (CN)
YANG BAI (CN)
Application Number:
PCT/CN2022/110533
Publication Date:
February 09, 2023
Filing Date:
August 05, 2022
Export Citation:
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Assignee:
UNIV JILIN (CN)
International Classes:
C12Q1/6874
Domestic Patent References:
WO2020123319A22020-06-18
Foreign References:
CN113604547A2021-11-05
CN110804654A2020-02-18
CN109762728A2019-05-17
CN103781918A2014-05-07
US20180245142A12018-08-30
US20180237782A12018-08-23
Other References:
VICKOVIC SANJA; ERASLAN GöKCEN; SALMéN FREDRIK; KLUGHAMMER JOHANNA; STENBECK LINNEA; SCHAPIRO DENIS; ÄIJö TARM: "High-definition spatial transcriptomics for in situ tissue profiling", NATURE METHODS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 16, no. 10, 9 September 2019 (2019-09-09), New York, pages 987 - 990, XP036887805, ISSN: 1548-7091, DOI: 10.1038/s41592-019-0548-y
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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