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Title:
HOLLOW FIBER MEMBRANE AND METHOD OF MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/1998/034719
Kind Code:
A1
Abstract:
A hollow fiber membrane which is excellent in material separation performance and performance of removing high molecular materials in blood, represented by $g(b)�2? microglobulin (molecular weight of 11,800 dalton) to suppress invasion of endotoxin fragments from a dializing fluid into a patient's body to provide an excellent biological compatibility when used in blood dialysis. The hollow fiber membrane has a speed of water permeability of 30 to 300 ml/m?2�.hr.mmHg, film thickness of 5 to 50 $g(m)m, pore diameter D�1? on an inner wall surface, which is represented by 10$m(F)D�1?$m(F)300 nm, pore diameter D�2? on an outer wall surface, which is represented by 0.6D�1?$m(F)D�2?$m(F)1.2D�1? and a pore diameter D�3? in the membrane, which is represented by D�3?$m(G)1.2D�1?, and the pore diameter continuously increases from the inner wall surface of the membrane toward an inner part thereof and continuously decreases from the inner part of the membrane toward the outer wall surface thereof, such that it has at least one maximum portion in the inner part of the membrane with a rate of increase ($g(r)�1?) of the pore diameter in the inner wall layer and a rate ($g(r)�2?) of decrease of the pore diameter in the outer wall layer, respectively, being 20 to 200 %. The hollow fiber membrane of the invention is manufactured by discharging a spinning solution composed of polymer and a solvent of the polymer from outside spinning ports on double annular spinning nozzles, discharging a hollow portion forming agent from inside spinning ports, and sequentially solidifying the spinning solution in two or more stage coagulation baths composed of a solution, which has a faster coagulating speed than water.

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Inventors:
FUKUDA MAKOTO
MIYAZAKI MAKATO
Application Number:
PCT/JP1997/000330
Publication Date:
August 13, 1998
Filing Date:
February 07, 1997
Export Citation:
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Assignee:
ASAHI CHEMICAL IND (JP)
International Classes:
A61M1/18; B01D67/00; B01D69/02; B01D69/08; B01D71/10; D01D5/24; D01F2/04; (IPC1-7): B01D69/08; B01D71/10; D01D5/24; D01F2/04
Foreign References:
JPS59204911A1984-11-20
JPS54145379A1979-11-13
JPS6045358A1985-03-11
JPS5735905A1982-02-26
JPS59160507A1984-09-11
JPS53106769A1978-09-18
Other References:
See also references of EP 0913186A4
Attorney, Agent or Firm:
Ishida, Takashi (Toranomon 37 Mori Building 5-1, Toranomon 3-chom, Minato-ku Tokyo 105, JP)
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