Title:
Hsp90 FAMILY PROTEIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2004/024141
Kind Code:
A1
Abstract:
It is intended to provide an Hsp90 family protein inhibitor, etc. comprising as the active ingredient a cyclic phenylacetic acid derivative represented by the following general formula (I), which is useful as drugs such as an antitumor agent, or its pharmacologically acceptable salt: (I) wherein R1, R2, R3 and R4 are the same or different and each represents hydrogen, hydroxy, optionally substituted lower alkyl, etc.; X represents oxygen, sulfur, -N(R5)- or -CH2-; a represents -CRa1Ra2-, optionally substituted arylene, an optionally substituted divalent heterocyclic group or a bond; b represents -(CRb1Rb2)m- or -CHRb3CRb4Rb5-; c represents -(CRc1Rc2)n(CHRc3CRc4Rc5)p-; d represents -(CRd1CRd2)q- or -CHRd3CRd4Rd5-; and e represents -CRe1Re2-.
Inventors:
AGATSUMA TSUTOMU (JP)
KANDA YUTAKA (JP)
ONODERA HIDEYUKI (JP)
MATSUSHITA NORIKO (JP)
OGAWA TATSUHIRO (JP)
AKINAGA SHIRO (JP)
SOGA SHIRO (JP)
KANDA YUTAKA (JP)
ONODERA HIDEYUKI (JP)
MATSUSHITA NORIKO (JP)
OGAWA TATSUHIRO (JP)
AKINAGA SHIRO (JP)
SOGA SHIRO (JP)
Application Number:
PCT/JP2003/011087
Publication Date:
March 25, 2004
Filing Date:
August 29, 2003
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
AGATSUMA TSUTOMU (JP)
KANDA YUTAKA (JP)
ONODERA HIDEYUKI (JP)
MATSUSHITA NORIKO (JP)
OGAWA TATSUHIRO (JP)
AKINAGA SHIRO (JP)
SOGA SHIRO (JP)
AGATSUMA TSUTOMU (JP)
KANDA YUTAKA (JP)
ONODERA HIDEYUKI (JP)
MATSUSHITA NORIKO (JP)
OGAWA TATSUHIRO (JP)
AKINAGA SHIRO (JP)
SOGA SHIRO (JP)
International Classes:
A61K31/365; A61P35/00; A61P43/00; C07D313/00; (IPC1-7): A61K31/365; A61P35/00; A61P43/00; C07D313/00; C07D493/04; C07D493/08
Domestic Patent References:
| WO2002057258A1 | 2002-07-25 | |||
| WO2000038674A1 | 2000-07-06 | |||
| WO2003050295A2 | 2003-06-19 |
Foreign References:
| JPH10218768A | 1998-08-18 |
Other References:
KI S.W. ET AL.: "Radicicol binds and inhibits mammalian ATP citrate lyase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 50, 2000, pages 39231 - 39236, XP002190759
FURSTNER A. ET AL.: "Macrocycles by ring-closing-metathesis, XI: syntheses of (R)-(+)-lasiodiplodin, zeranol and truncated salicylihalamides", TETRAHEDRON, vol. 55, 1999, pages 8215 - 8230, XP004169314
IKUINA Y. ET AL.: "Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol", J. MED. CHEM., vol. 46, 2003, pages 2534 - 2541, XP002975841
FURSTNER A. ET AL.: "Macrocycles by ring-closing-metathesis, XI: syntheses of (R)-(+)-lasiodiplodin, zeranol and truncated salicylihalamides", TETRAHEDRON, vol. 55, 1999, pages 8215 - 8230, XP004169314
IKUINA Y. ET AL.: "Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol", J. MED. CHEM., vol. 46, 2003, pages 2534 - 2541, XP002975841
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