Title:
HUMAN MYD88 ADAPTER-LIKE PROTEIN AND FUNCTIONAL FRAGMENTS THEREOF
Document Type and Number:
WIPO Patent Application WO2001088137
Kind Code:
A3
Abstract:
There are disclosed MAL-1 polypeptides and active fragments of MAL-1, including fragments that associate with IRAK2. Further disclosed are DNAs encoding the polypeptides and fragments as well as methods of using the DNAs and polypeptides.
Inventors:
SIMS JOHN E (US)
BIRD TIMOTHY A (US)
O'NEILL LUKE A J (IE)
BIRD TIMOTHY A (US)
O'NEILL LUKE A J (IE)
Application Number:
PCT/US2001/016017
Publication Date:
July 18, 2002
Filing Date:
May 16, 2001
Export Citation:
Assignee:
IMMUNEX CORP (US)
SIMS JOHN E (US)
BIRD TIMOTHY A (US)
O'NEILL LUKE A J (IE)
SIMS JOHN E (US)
BIRD TIMOTHY A (US)
O'NEILL LUKE A J (IE)
International Classes:
C07K14/715; C12N1/19; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C07K14/47; G01N33/68
Domestic Patent References:
| WO2000060080A2 | 2000-10-12 |
Other References:
MEANS TK ET AL.: "The biology of Toll-like receptors", CYTOK. GROWTH FACT. REV., vol. 11, 2000, pages 219 - 232, XP002190964
MUZIO M ET AL: "IRAK (Pelle) family member IRAK - 2 and MyD88 as proximal mediators of IL-1 signaling", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 278, 28 November 1997 (1997-11-28), pages 1612 - 1615, XP002099801, ISSN: 0036-8075
FITZGERALD KA ET AL.: "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.", NATURE, vol. 413, 6 September 2001 (2001-09-06), pages 78 - 83, XP002190965
MUZIO M ET AL: "IRAK (Pelle) family member IRAK - 2 and MyD88 as proximal mediators of IL-1 signaling", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 278, 28 November 1997 (1997-11-28), pages 1612 - 1615, XP002099801, ISSN: 0036-8075
FITZGERALD KA ET AL.: "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.", NATURE, vol. 413, 6 September 2001 (2001-09-06), pages 78 - 83, XP002190965
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