HUMAN PROTEINS HAVING SECRETORY SIGNAL SEQUENCES AND cDNAS ENCODING THESE PROTEINS

WIPO Patent Application WO1999018204

A3

The invention provides human proteins having secretory signal sequences and DNAs coding for these proteins as well as eucaryotic cells forming said proteins by secretory expression. All of the proteins are secreted outside the cells and exist in the extracellular liquid or on the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals or as antigens for preparing antibodies against said proteins. Furthermore, said DNAs can be utilized for expression of said proteins in large amounts. Eucaryotic cells wherein expression vectors of said cDNAs are introduced can be utilized for secretory production of the proteins encoded by said cDNAs.

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KATO SEISHI (JP)
KIMURA TOMOKO (JP)
SEKINE SHINGO (JP)
KOBAYASHI MIDORI (JP)

PCT/JP1998/004476

July 29, 1999

October 05, 1998

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SAGAMI CHEM RES (JP)
PROTEGENE INC (JP)
KATO SEISHI (JP)
KIMURA TOMOKO (JP)
SEKINE SHINGO (JP)
KOBAYASHI MIDORI (JP)

C07K14/47; C12N15/12; (IPC1-7): C12N15/12; C07K14/47

WO1996039419A1	1996-12-12
WO1998044160A1	1998-10-08

YOKOYAMA-KOBAYASHI M ET AL: "A SIGNAL SEQUENCE DETECTION SYSTEM USING SECRETED PROTEASE ACTIVITY AS AN INDICATOR", GENE, vol. 163, 1995, pages 193 - 196, XP002046435
TASHIRO K ET AL: "SIGNAL SEQUENCE TRAP: A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE I MEMBRANE PROTEINS", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204

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