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Title:
HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND cDNAs ENCODING THESE PROTEINS
Document Type and Number:
WIPO Patent Application WO1999018203
Kind Code:
A3
Abstract:
The invention provides human proteins having transmembrane domains and cDNAs coding for these proteins as well as eukaryotic cells expressing said cDNAs. All of the proteins exist in the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals such as carcinostatic agents relating to the control of the proliferation and the differentiation of the cells or as antigens for preparing antibodies against said proteins. The cDNAs can be utilized as probes for the gene diagnosis and gene sources for the gene therapy. Furthermore, the cDNAs can be utilized for large-scale expression of said proteins. Cells, wherein these membrane protein genes are introduced and membrane proteins are expressed in large amounts, can be utilized for detection of the corresponding ligands, screening of novel low-molecular pharmaceuticals, and so on.

Inventors:
KATO SEISHI (JP)
KIMURA TOMOKO (JP)
SEKINE SHINGO (JP)
KOBAYASHI MIDORI (JP)
Application Number:
PCT/JP1998/004475
Publication Date:
June 24, 1999
Filing Date:
October 05, 1998
Export Citation:
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Assignee:
SAGAMI CHEM RES (JP)
PROTEGENE INC (JP)
KATO SEISHI (JP)
KIMURA TOMOKO (JP)
SEKINE SHINGO (JP)
KOBAYASHI MIDORI (JP)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C12N15/12; C07K14/47; C12N5/10; C12N15/79
Domestic Patent References:
WO1998000540A11998-01-08
WO1998051805A11998-11-19
WO1998051824A11998-11-19
Other References:
Genbank Database Entry GGSCA2A Accession number L34554; 16 July 1994 PETRENKO O. ET AL.:"Characterization of changes in gene expression associated with leukemic transformation by the NK-kB family member v-Rel"
EMBL Database Entry HS1268023 Accession number AA476643; 23 June 1997 HILLIER ET AL.:"WashU-Merck EST Project 1997"
ROBERT E. REITER ET AL.: "Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, no. 4, 17 February 1998 (1998-02-17), WASHINGTON US, pages 1735 - 1740, XP002089381
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