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Patent Searching and Data


Title:
HUMAN SCHIZOPHRENIA GENE
Document Type and Number:
WIPO Patent Application WO2001064876
Kind Code:
A3
Abstract:
Nucleic acids comprising the neuregulin-1-associated gene 1 (NRG1AG1) and encoding NRG1AGI polypeptides are disclosed. Also described are related nucleic acids encoding NRG1AG1 polypeptides; NRG1AG1 polypeptides; antibodies that bind to NRG1AG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1AG1 polypeptide or which identify NRG1AG1 binding agents, and the agents or binding agents identified by the assays; NRG1AG1 therapeutic agents, including the NRG1AG1 nucleic acids, NRG1AG1 polypeptides, or agents that alter the activity of a NRG1AG1 polypeptides; pharmaceutical compositions comprising the NRG1AG1 therapeutic agents; as well as methods of therapy of schizophrenia.

Inventors:
STEFANSSON HREINN (IS)
STEINTHORSDOTTIR VALGERDUR (IS)
GULCHER JEFFREY R (US)
Application Number:
PCT/US2001/006376
Publication Date:
April 18, 2002
Filing Date:
February 28, 2001
Export Citation:
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Assignee:
DECODE GENETICS EHF (IS)
STEFANSSON HREINN (IS)
STEINTHORSDOTTIR VALGERDUR (IS)
GULCHER JEFFREY R (US)
International Classes:
A61K38/00; A61K45/00; A61K48/00; A61P25/18; C07K14/47; C07K14/475; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; A01K67/027; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; C12N15/10; C12N15/66; C12N15/62; C07K14/475; C07K16/22; C12Q1/68; G01N33/68; G01N33/577; G01N33/50; A61K38/18; A61K31/70; A01K67/027
Domestic Patent References:
WO1994028133A11994-12-08
Foreign References:
Other References:
CLAVERIE J-M ET AL: "ALU ALERT", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 371, 27 October 1994 (1994-10-27), pages 752, XP002070602, ISSN: 0028-0836
BLOUIN J-L ET AL: "SCHIZOPHRENIA SUSCEPTIBILITY LOCI ON CHROMOSOMES 13Q32 AND 8P21", NATURE GENETICS, NEW YORK, NY, US, vol. 20, no. 1, September 1998 (1998-09-01), pages 70 - 73, XP000944108, ISSN: 1061-4036
DOMBROSKI B A ET AL: "Narrowing of a susceptibility region for schizophrenia on chromosome 8p21-p22 to within 4Mb.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 59, no. 4 SUPPL., 1996, 46th Annual Meeting of the American Society of Human Genetics;San Francisco, California, USA; October 29-November 2, 1996, pages A216, XP001030998, ISSN: 0002-9297
MEYER DIRK ET AL: "Isoform-specific expression and function of neuregulin.", DEVELOPMENT (CAMBRIDGE), vol. 124, no. 18, 1997, pages 3575 - 3586, XP001030844, ISSN: 0950-1991
FISCHBACH GERALD D ET AL: "ARIA: A neuromuscular junction neuregulin.", 1997, ANNUAL REVIEW OF NEUROSCIENCE, VOL. 20, PAGE(S) 429-458, 1997 ANNUAL REVIEWS INC. P.O. BOX 10139, 4139 EL CAMINO WAY, PALO ALTO, CALIFORNIA 94306, USA, ISBN: 0-8243-2420-X, XP001030893
DATABASE SRS6 16 October 2001 (2001-10-16), "http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-e+[swall-id:NRG1_HUMAN]", XP002181593
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