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Title:
HUMAN SCHIZOPHRENIA GENE
Document Type and Number:
WIPO Patent Application WO2001064877
Kind Code:
A9
Abstract:
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia.

Inventors:
STEFANSSON HREINN (IS)
STEINTHORSDOTTIR VALGERDUR (IS)
GULCHER JEFFREY R (US)
Application Number:
PCT/US2001/006377
Publication Date:
January 30, 2003
Filing Date:
February 28, 2001
Export Citation:
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Assignee:
DECODE GENETICS EHF (IS)
STEFANSSON HREINN (IS)
STEINTHORSDOTTIR VALGERDUR (IS)
GULCHER JEFFREY R (US)
International Classes:
G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/18; C07K14/475; C07K14/485; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; C12N15/10; C12N15/66; C12N15/62; C07K14/475; C07K16/22; C12Q1/68; G01N33/68; G01N33/577; G01N33/50; A61K38/18; A61K31/70; A01K67/027
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