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Title:
HUMAN TUMOR NECROSIS FACTOR RECEPTOR TR10
Document Type and Number:
WIPO Patent Application WO2000073321
Kind Code:
A9
Abstract:
The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.

Inventors:
ROSEN CRAIG A (US)
NI JIAN (US)
Application Number:
PCT/US2000/014554
Publication Date:
July 11, 2002
Filing Date:
May 26, 2000
Export Citation:
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Assignee:
HUMAN GENOME SCIENCES INC (US)
ROSEN CRAIG A (US)
NI JIAN (US)
International Classes:
C12N15/09; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61K48/00; A61P1/14; A61P1/18; A61P9/10; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/00; C07K14/705; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12R1/19; C12R1/91; (IPC1-7): C07H21/04; C12P21/06; A61K38/00
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