Title:
HYALURONIC ACID DERIVATIVE COMPOSITION, PHARMACEUTICAL COMPOSITION AND HYALURONIC ACID DERIVATIVE-DRUG CONJUGATE COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/157677
Kind Code:
A1
Abstract:
Provided are: a hyaluronic acid derivative composition that comprises (A) a hyaluronic acid derivative having a steryl group introduced therein and (B) a polar group-containing compound having at least one kind of functional group selected from the group consisting of hydroxy group, carboxy group, amino group, amide group, carbamate group, urea group and thiol group, wherein the steryl group has been introduced at a ratio of 0.1% or more and less than 35% relative to the hyaluronic acid derivative (A); a pharmaceutical composition that contains the hyaluronic acid derivative composition as a carrier; and a hyaluronic acid derivative-drug conjugate composition wherein, in the hyaluronic acid derivative composition, one or more drugs are conjugated to the hyaluronic acid derivative (A).
Inventors:
NAKAGAWA YOSHIYUKI (JP)
YABUUCHI KOHEI (JP)
FUKUMOTO KEISUKE (JP)
KATSUMATA TORU (JP)
YANG SOYEUN (JP)
YABUUCHI KOHEI (JP)
FUKUMOTO KEISUKE (JP)
KATSUMATA TORU (JP)
YANG SOYEUN (JP)
Application Number:
PCT/JP2021/004200
Publication Date:
August 12, 2021
Filing Date:
February 05, 2021
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
International Classes:
A61K45/00; A61K9/06; A61K31/7088; A61K38/02; A61K47/10; A61K47/36; A61K47/61; A61P43/00; C08B37/08
Domestic Patent References:
| WO2014038641A1 | 2014-03-13 | |||
| WO2010053140A1 | 2010-05-14 | |||
| WO2017195880A1 | 2017-11-16 | |||
| WO2019098393A1 | 2019-05-23 | |||
| WO2020158771A1 | 2020-08-06 | |||
| WO2010053140A1 | 2010-05-14 |
Foreign References:
| CN103435718A | 2013-12-11 | |||
| JP2005139409A | 2005-06-02 | |||
| JPH0558881A | 1993-03-09 | |||
| JP2016500130A | 2016-01-07 | |||
| JP2020018312A | 2020-02-06 |
Other References:
ZHU QIUWEN, CHEN XIAOJIE, XU XIAO, ZHANG YING, ZHANG CAN, MO RAN: "Tumor-Specific Self-Degradable Nanogels as Potential Carriers for Systemic Delivery of Anticancer Proteins", ADVANCED FUNCTIONAL MATERIALS, vol. 28, no. 17, 2018, pages 1 - 10, XP055845713, DOI: 10.1002/adfm.201707371
YUTAKA MASUDA, HIROKI MATSUSHIMA, SETSUKO YAMANE, KIYOSHI ONUMA, SHINICHI SAWADA, YOSHIHIRO SASAKI, KAZUNARI AKIYOSHI: "1PB-030 Synthesis of Silica-Hydrophobized Hyaluronic Acid Hybrid Hydrogel", PROCEEDINGS OF THE 99TH ANNUAL SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KOBE, JAPAN; MARCH 16-19, 2019, vol. 99, 30 November 2018 (2018-11-30) - 19 March 2019 (2019-03-19), pages 1PB - 030, XP009538319
YAMANE, SETSUKO; OHNUMA, KIYOSHI; SAWADA, SHIN-ICHI; SASAKI, YOSHIHIRO; AKIYOSHI, KAZUNARI: "2B6-29 Synthesis of hydrophobized hyaluronic acid-calcium phosphate hybrid fine particle", PROCEEDINGS OF THE 96TH ANNUAL SPRING CONFERENCE OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KYOTANABE, JAPAN; MARCH 24-27, 2016, vol. 96, 30 November 2015 (2015-11-30) - 27 March 2016 (2016-03-27), pages 2B6 - 29, XP009538320
See also references of EP 4101466A4
YUTAKA MASUDA, HIROKI MATSUSHIMA, SETSUKO YAMANE, KIYOSHI ONUMA, SHINICHI SAWADA, YOSHIHIRO SASAKI, KAZUNARI AKIYOSHI: "1PB-030 Synthesis of Silica-Hydrophobized Hyaluronic Acid Hybrid Hydrogel", PROCEEDINGS OF THE 99TH ANNUAL SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KOBE, JAPAN; MARCH 16-19, 2019, vol. 99, 30 November 2018 (2018-11-30) - 19 March 2019 (2019-03-19), pages 1PB - 030, XP009538319
YAMANE, SETSUKO; OHNUMA, KIYOSHI; SAWADA, SHIN-ICHI; SASAKI, YOSHIHIRO; AKIYOSHI, KAZUNARI: "2B6-29 Synthesis of hydrophobized hyaluronic acid-calcium phosphate hybrid fine particle", PROCEEDINGS OF THE 96TH ANNUAL SPRING CONFERENCE OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KYOTANABE, JAPAN; MARCH 24-27, 2016, vol. 96, 30 November 2015 (2015-11-30) - 27 March 2016 (2016-03-27), pages 2B6 - 29, XP009538320
See also references of EP 4101466A4
Attorney, Agent or Firm:
MATSUNUMA Yasushi et al. (JP)
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