HYDANTOIN DERIVATIVE - ONO PHARMACEUTICAL CO

Title:

HYDANTOIN DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2021/043245

Kind Code:

A1

Abstract:

A compound represented by general formula (I-a) : has a strong DDR1 inhibitory activity, and can be a therapeutic agent for DDR1-related diseases, for example, a cancer, a kidney disease, a cardiovascular disease, a central nervous system disease, or fibrosis.

Inventors:

NISHIOKA YOTA (JP)
KURONO MASAKUNI (JP)
NISHIZAWA RENA (JP)
BANDODKAR BALACHANDRA (CN)
GAO XUECHAO (CN)
WAN ZHILONG (CN)
LV RANRAN (CN)
DOYLE KEVIN (GB)
GOLDSMITH MICHAEL (GB)

Application Number:

PCT/CN2020/113408

Publication Date:

March 11, 2021

Filing Date:

September 04, 2020

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)
PHARMARON BEIJING CO LTD CHINA (CN)

International Classes:

C07D401/14; A61K31/4164; A61P9/00; A61P25/00; A61P35/00; C07D401/12

Domestic Patent References:

WO2019014304A1	2019-01-17
WO2006039718A2	2006-04-13
WO2007065939A1	2007-06-14
WO2011098776A1	2011-08-18
WO2019099307A1	2019-05-23
WO2014108820A1	2014-07-17
WO2010045303A2	2010-04-22

Foreign References:

CN101217954A	2008-07-09
CN105873917A	2016-08-17
CN110049977A	2019-07-23
US20140221374A1	2014-08-07
CN107530304A	2018-01-02
CN102884057A	2013-01-16

Other References:

DATABASE REGISTRY STN; 19 January 2012 (2012-01-19), ANONYMOUS: "2H-Pyrrolo[2,3-b]pyridin-2-one, 1,3-dihydro-1-[4-(2-oxo-3-phenyl-1- imidazolidinyl)phenyl]- (CA INDEX NAME)", XP055788534, Database accession no. RN 1353679-06-7
See also references of EP 4025570A4

Attorney, Agent or Firm:

LIU, SHEN & ASSOCIATES (CN)

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