HYDROGEL INCLUSION COMPLEX CONTAINING BIOACTIVE SUBSTANCE BOUND TO TEMPERATURE-SENSITIVE POLYPHOSPHAZENE BY HOST-GUEST INTERACTION THROUGH BETA-CYCLODEXTRIN, AND USE THEREOF

WIPO Patent Application WO/2020/256287

A3

The present application pertains to a hydrogel composition containing: a temperature-sensitive polyphosphazene in which a plurality of hydrophobic amino acids, hydrophilic polymers, and host molecules are substituted; and a bioactive substance to which guest molecules are linked, wherein the guest molecules are encapsulated in the host molecules by host-guest interaction and form a conjugate between the polyphosphazene and the bioactive substance. When introduced into a living body, the hydrogel composition of the present application gradually releases the bioactive substance and provides favorable conditions for stem cell differentiation. In addition, the hydrogen composition of the present application, in which the type, proportion, and arrangement of the bioactive substance are controlled to be suitable for the specific differentiation of stem cells, can be prepared with high reproducibility.

SONG SOO CHANG (KR)
HONG KI HYUN (KR)

PCT/KR2020/006548

February 11, 2021

May 19, 2020

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KOREA INST SCI & TECH (KR)

C08B37/16; A61K47/58; A61K47/69; A61L27/38; A61L27/52; A61L27/54; C08G79/025; C08L5/16; C08L85/02

KR20030081354A	2003-10-17
KR20110086326A	2011-07-28
JP4451985B2	2010-04-14
KR101622851B1	2016-05-20
KR101783308B1	2017-09-29
KR20080110473A	2008-12-18

HANOL INTELLECTUAL PROPERTY AND LAW (KR)

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