HYDROXAMIC ACID COMPOUND HAVING ENPP1 INHIBITORY ACTIVITY AND USE THEREOF

Title:

HYDROXAMIC ACID COMPOUND HAVING ENPP1 INHIBITORY ACTIVITY AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/036289

Kind Code:

A1

Abstract:

Disclosed are a compound of formula (I) having ENPP1 inhibitory activity, a pharmaceutical composition thereof and use thereof. The compound of formula (I) can be used for preventing or treating the diseases or disorders mediated by the ENPP1 abnormal activity.

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Inventors:

GAO SHANYUN (CN)
LI JINGJING (CN)
ZHANG CHAOBO (CN)
XU YANXIAO (CN)
TU WANGYANG (CN)
YU BING (CN)
ZHANG YIXIANG (CN)
LI LEPING (CN)

Application Number:

PCT/CN2022/118080

Publication Date:

March 16, 2023

Filing Date:

September 09, 2022

Export Citation:

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Assignee:

HAIHE BIOPHARMA CO LTD (CN)

International Classes:

C07D239/94; A61K31/47; A61K31/517; A61K31/519; A61P31/04; A61P31/12; A61P35/00; C07D215/233; C07D215/36; C07D215/38; C07D239/88; C07D239/93; C07D471/04

Domestic Patent References:

WO2020160333A1	2020-08-06
WO2019046778A1	2019-03-07
WO2020008391A1	2020-01-09
WO2020058290A1	2020-03-26
WO2019046778A1	2019-03-07

Foreign References:

CN107513064A	2017-12-26
CN112390781A	2021-02-23

Other References:

LI, SHUNDA ET AL.: "Development of selective HDAC6 inhibitors with in vitro and in vivo anti-multiple myeloma activity", BIOORGANIC CHEMISTRY, vol. 116, 19 August 2021 (2021-08-19), XP086829615, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2021.105278
ZENG, HUIJU ET AL.: "Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 192, 29 February 2020 (2020-02-29), XP086102471, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112193
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING COMPANY, pages: 1289 - 1329
"Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY
CELL CHEMICAL BIOLOGY, no. 27, 2020, pages 1347 - 1358

Attorney, Agent or Firm:

ZHONGZI LAW OFFICE (CN)

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