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Patent Searching and Data


Title:
HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001017955
Kind Code:
A3
Abstract:
A compound of formula (I) wherein: R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<7> are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.

Inventors:
BUTLIN ROGER JOHN (GB)
PEASE JANET ELIZABETH (GB)
BLOCK MICHAEL HOWARD (GB)
NOWAK THORSTEN (GB)
BURROWS JEREMY NICHOLAS (GB)
Application Number:
PCT/GB2000/003303
Publication Date:
June 21, 2001
Filing Date:
August 30, 2000
Export Citation:
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Assignee:
ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
BUTLIN ROGER JOHN (GB)
PEASE JANET ELIZABETH (GB)
BLOCK MICHAEL HOWARD (GB)
NOWAK THORSTEN (GB)
BURROWS JEREMY NICHOLAS (GB)
International Classes:
A61K31/18; A61K31/40; A61K31/44; A61K31/4406; A61K31/445; A61K31/5375; A61P3/10; A61P9/00; A61P9/10; A61P31/04; C07D295/22; A61P43/00; C07C311/46; C07C323/67; C07D207/12; C07D211/46; C07D211/96; C07D213/76; C07D295/26; (IPC1-7): C07C311/46; C07C323/67; C07D207/12; C07D211/46; C07D213/76; C07D295/26; A61K31/18; A61P5/48; A61P9/00; A61P9/10
Foreign References:
EP0625516A11994-11-23
Other References:
T.D. AICHER, ET AL.: "(R)-3,3,3-Trifluoro-2-hydroxy-2- methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 14 July 1999 (1999-07-14), American Chemical Society, Washington, DC, US, pages 2741 - 2746, XP002122777, ISSN: 0022-2623
C.J. OHNMACHT, ET AL.: "N-Aryl-3,3,3-trifluoro-2-hydroxy-2- methylpropanamides: KATP potassium channel openers. Modifications on the western region", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 23, 8 November 1996 (1996-11-08), American Chemical Society, Washington, DC, US, pages 4592 - 4601, XP002111499, ISSN: 0022-2623
J.R. EMPFIELD, ET AL.: "4-Sulphonamidoanilide tertiary carbinols: a novel series of potassium channel openers", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 7, 8 April 1997 (1997-04-08), Elsevier Science Publishers, Amsterdam, NL, pages 775 - 778, XP004136128, ISSN: 0960-894X
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