IDENTIFICATION OF SPLICING-DERIVED ANTIGENS FOR TREATING

CANCER

BACKGROUND OF THE INVENTION

[0001] This application claims benefit of priority of U.S. Provisional Patent Application No. 62/934,914, filed November 13, 2019 and U.S. Provisional Patent Application No. 62/932,751, filed November 8, 2019, both of which are hereby incorporated by reference in their entireties.

[0002] This invention was made with government support under Grant Numbers CA211015 and CA233074, awarded by the National Institutes of Health. The government has certain rights in the invention.

II. Field of the Invention

[0003] This invention relates to the field of cancer therapies.

III. Background

[0004] Cancer immunotherapy has gained tremendous momentum in the past decade. The clinical effectiveness of checkpoint inhibitors, such as neutralizing antibodies against PD- 1 and CTLA-4, is thought to result from their ability to reactivate tumor-specific T cells. Meanwhile, adoptive cell therapies use genetically modified T-cell receptors (TCRs) or synthetic chimeric antigen receptor T cells (CAR-T) for tumor-specific antigen recognition. The finding that cancer cells express specific T-cell-reactive antigens has galvanized epitope discovery in recent years. Nevertheless, the identification of tumor antigens remains a major challenge. Although somatic mutation-derived antigens have been successfully targeted by cancer therapies, this approach remains largely ineffective for tumors with low or moderate mutation loads. Thus, there is a need in the art for the identification and characterization of novel tumor antigens that are useful targets in cancer immunotherapies.

SUMMARY OF THE INVENTION

[0005] Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments. Also described are novel tumor antigens that are useful as targets in various immunotherapeutic approaches to treating brain cancer as well as novel engineered T cell Receptors (TCRs) and chimeric antigen receptors (CARs) that target these antigenic peptides.

[0006] In several embodiments, RNA sequencing (RNA-seq) data derived from a neoplastic source (or a collection of neoplastic sources) are utilized to identify AS events. In a number of embodiments, neoplastic AS events are compared to AS events of non-neoplastic tissue such that AS events that are specific or increased in neoplastic tissue are identified. In some embodiments, neoplastic AS events are compared to AS events in similar neoplastic tissue such that recurrent AS events in neoplastic tissue are identified. Various processes to validate neoplastic AS events are performed, in accordance with some embodiments. Likewise, several embodiments utilize the identification of neoplastic AS events to synthesize peptides for use as an antigen of the neoplastic tissue.

[0007] Alternative splicing is a major cellular mechanism for generating expression complexity, especially in regulatory and functional aspects (e.g., two splice variants of the same gene can have different regulatory and functional properties). In addition, alternative splicing contributes to the diversity of phenotypes in eukaryotic cells of an organism, where each cell has the same DNA genotype. In neoplastic cells, alternative splicing mechanisms can be dysregulated, leading to aberrant expression of various isoforms and formation of neoplasm antigens. Various embodiments are directed towards identifying dysregulated isoforms and neoplasm antigens, which can be utilized in a number of applications. For instance, identified AS events can be utilized to develop peptides that are encoded by nucleotides that span the splice junction and these peptides may be utilized to develop various cancer treatments.

[0008] Aspects of the disclosure relate to an engineered T-cell Receptor (TCR) comprising: a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:30 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:31; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:32 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO: 33; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:34 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:35; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:36 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:37; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:38 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:39; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:40 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:41; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:42 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:43 or a TCR-a and TCR-b CDR3 comprising an amino acid sequence with at least 90% sequence identity to a TCR-a and TCR-b CDR3 pair from a clonotype listed in Table 6..

[0009] Further aspects relate to one or more nucleic acids encoding a TCR, CAR, or peptide of the disclosure. Certain aspects relate to a nucleic acid encoding a TCR-alpha and/or TCR- beta polypeptide. Also provided are nucleic acid vector(s) comprising the nucleic acid(s) of the disclosure. Further aspects relate to a cell, such as a therapeutic cell or a host cell, comprising a TCR, CAR, nucleic acid, or vector of the disclosure. Also provided are compositions comprising the cells, nucleic acids, or peptides of the disclosure. Yet further aspects relate to an in vitro isolated dendritic cell comprising a peptide, nucleic acid, or expression vector of the disclosure. Further aspects relate to an in vitro composition comprising a dendritic cell and a peptide of the disclosure. Further aspects relate to an engineered T-cell Receptor (TCR) or chimeric antigen receptor (CAR) that specifically recognizes a peptide of the disclosure. Aspects of the disclosure also relate to an antibody or antigen binding fragment thereof that specifically recognizes and binds to a peptide of the disclosure.

[0010] Further aspects of the disclosure relate to a method comprising transferring a nucleic acid of the disclosure into a cell. Further method aspects of the disclosure relate to a method for stimulating an immune response or for treating brain cancer comprising administering a composition, peptide, antibody, therapeutic cell, CAR, or TCR of the disclosure to a subject. Other method aspects of the disclosure relate to an in vitro method for making a dendritic cell vaccine comprising contacting a dendritic cell in vitro with a peptide of the disclosure. Other method aspects relate to a method of treating a subject for brain cancer comprising administering a peptide, composition, dendritic cell, antibody or antigen binding fragment, or cell of the disclosure.

[0011] Further aspects relate to: a peptide from the TRIM11 protein comprising at least 6 contiguous amino acids from the TRIM11 and comprising the amino acids QD, which correspond to the amino acids at positions 168-169 of SEQ ID NO:l; a peptide from the RCOR3 protein comprising at least 6 contiguous amino acids from the RCOR3 and comprising the amino acids QG, which correspond to the amino acids at positions 358-359 of SEQ ID NO:2; a peptide from the FAM76B protein comprising at least 6 contiguous amino acids from the FAM76B and comprising the amino acids DS, which correspond to the amino acids at positions 230-231 of SEQ ID NO:3; a peptide from the SLMAP protein comprising at least 6 contiguous amino acids from the SLMAP and comprising the amino acids NP, which correspond to the amino acids at positions 332-333 of SEQ ID NO:4; a peptide from the TMEM62 protein comprising at least 6 contiguous amino acids from the TMEM62 and comprising the amino acids LG, which correspond to the amino acids at positions 495-496 of SEQ ID NO:5; and/or a peptide from the PLA2G6 protein comprising at least 6 contiguous amino acids from the PLA2G6 and comprising the amino acids RL, which correspond to the amino acids at positions 395-396 of SEQ ID NO:6. Further aspects relate to a peptide comprising at least 6 contiguous amino acids from a peptide of Table la, Table lb, Table lc, or 4, wherein the peptide comprises an alternative splice site junction. Yet further aspects relate to a peptide comprising at least 6 contiguous amino acids encoded by an alternatively spliced nucleic acid, wherein the at least 6 contiguous amino acids are encoded on a nucleic acid that comprises an alternative splice site junction, and wherein the alternative splice site junction is an AS event selected from an AS event in Table 3a or 3b.. An alternative splice site junction in a polypeptide refers to the amino acids that are encoded by the region of the mRNA that spans the alternative splice site. An alternative splice site in a nucleic acid refers to the nucleic acid residues that span the alternative splice site.

[0012] Also provided is a method of activating or expanding peptide-specific T cells comprising contacting a starting population of T cells from a mammalian subject and preferably from a blood sample from the mammalian subject cells ex vivo with the peptide of disclosure thereby activating, stimulating proliferation, and/or expanding peptide-specific T cells in the starting population. Further aspects relate to a peptide-specific T cell activated or expanded according to a method of the disclosure. Also provided are pharmaceutical compositions comprising the peptide-specific T cells activated or expanded according to a method of the disclosure.

[0013] In some embodiments, contacting is further defined as co-culturing the starting population of T cells with antigen presenting cells (APCs), wherein the APCs can present the peptide of the disclosure on their surface. In some embodiments, the APCs are dendritic cells. In some embodiments, the dendritic cells are autologous dendritic cells obtained from the mammalian subject. In some embodiments, contacting is further defined as co-culturing the starting population of T cells with artificial antigen presenting cells (aAPCs). In some embodiments, the artificial antigen presenting cells (aAPCs) comprise or consist of poly(lactide-co-glycolide) (PLGA), K562 cells, paramagnetic beads coated with CD3 and CD28 agonist antibodies, beads or microparticles coupled with an HLA-dimer and anti-CD28, or nanosize-aAPCs (nano-aAPC) that are preferably less than 100 nm in diameter. In some embodiments, the T cells are CD8+ T cells or CD4+ T cells. In some embodiments, the T cells are cytotoxic T lymphocytes (CTLs). In some embodiments, the starting population of cells comprises or consists of peripheral blood mononuclear cells (PBMCs). In some embodiments, the method further comprises isolating or purifying the T cells from the peripheral blood mononuclear cells (PBMCs). In some embodiments, the mammalian subject is a human. In some embodiments, the method further comprises reinfusing or administering the activated or expanded peptide-specific T cells to the subject. Further aspects relate to a peptide-specific T cell activated or expanded according to a method of the disclosure. Also provided are pharmaceutical compositions comprising the peptide-specific T cells activated or expanded according to a method of the disclosure.

[0014] In some embodiments, the AS event is selected from an AS event in Table 3a. In some embodiments, the AS event is selected from an AS event in Table 3b. In some embodiments, the disclosure relates to a CAR that targets a peptide of the disclosure, wherein the peptide comprises an AS event from table 3b. In some embodiments, the disclosure relates to a TCR that targets a peptide of the disclosure, wherein the peptide comprises an AS event from table 3a.

[0015] In some embodiments, the TCR comprises: engineered T-cell Receptor (TCR) comprising: a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:30 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:31; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:32 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:33; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:34 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:35; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:36 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:37; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:38 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO: 39; a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:40 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:41; or a TCR alpha (TCR-a) CDR3 comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:42 and a TCR beta (TCR-b) CDR3 comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:43.

[0016] In some embodiments, the TCR comprises: a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:44 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:45; a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:46 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:47; or a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:48 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 80% sequence identity to SEQ ID NO:49.

[0017] In some embodiments, the TCR comprises: a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:44 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:45; a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:46 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:47; or a TCR alpha (TCR-a) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:48 and a TCR beta (TCR-b) variable region comprising an amino acid sequence with at least 70, 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96 97, 98, 99, or 100% sequence identity to SEQ ID NO:49.

[0018] In some embodiments, the TCR comprises or consists of a bispecific TCR. The bispecific TCR may comprises an scFv that targets or selectively binds CD3. In some embodiments, the TCR is further defined as a single-chain TCR (scTCR), wherein the a chain and the b chain are covalently attached via a flexible linker.In some embodiments, the TCR comprises a modification or is chimeric. In some embodiments, the variable region of the TCR is fused to a TCR constant region that is different from the constant region of the cloned TCR that specifically binds to a peptide of the disclosure.

[0019] In some embodiments, the nucleic acid of the disclosure comprises a cDNA encoding the TCR. In some embodiments, the TCR alpha and beta genes are on the same nucleic acid and/or on the same vector.

[0020] In some embodiments, a cell of the disclosure comprises an immune cell. In some embodiments, a cell of the disclosure comprises stem cell, progenitor cell, T cell, NK cell, invariant NK cell, NKT cell, mesenchymal stem cell (MSC), induced pluripotent stem (iPS) cell, regulatory T cell, CD8+ T cell, CD4+ T cell, or gd T cell. In some embodiments, the cell comprises a hematopoietic stem or progenitor cell, a T cell, or an induced pluripotent stem cell (iPSC). In some embodiments, the cell is isolated from a cancer patient. In some embodiments, is a HLA-A type. The cell of the disclosure may be autologous or allogeneic. In some embodiments, the cell is a HLA-A*03:01, HLA-A*01:01, or HLA-A*02:01 type. In some embodiments, the cell comprises at least one TCR and at least one CAR and wherein the TCR and CAR each recognize a different peptide. For example, embodiments of the disclosure relate to a cell that comprises a TCR that targets one peptide of the disclosure and a CAR that targets a different peptide of the disclosure.

[0021] In some embodiments, the composition of the disclosure has been determined to be serum-free, mycoplasma-free, endotoxin-free, and/or sterile.

[0022] In some embodiments, the method further comprises culturing the cell in media, incubating the cell at conditions that allow for the division of the cell, screening the cell, and/or freezing the cell. In some embodiments, the method further comprises isolating the expressed peptide or polypeptide from a cell of the disclosure. [0023] In some embodiments, the brain cancer comprises glioblastoma or glioma. In some embodiments, the subject has previously been treated for the cancer. In some embodiments, the subject has been determined to be resistant to the previous treatment. In some embodiments, the method further comprises the administration of an additional therapy. In some embodiments, the additional therapy comprises an immunotherapy, chemotherapy, or an additional therapy described herein. In some embodiments, the cancer comprises stage I, II, III, or IV cancer. In some embodiments, the cancer comprises metastatic and/or recurrent cancer.

[0024] In some embodiments, a peptide of the disclosure comprises at least 6 contiguous amino acids from one of SEQ ID NOS:786 or 1364-1395. In some embodiments, a peptide of the disclosure has at least 70% sequence identity to a peptide of SEQ ID NO:786 or 1364-1395. In some embodiments, a peptide of the disclosure has at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NOS:786 or 1364-1395.

[0025] In some embodiments, the peptide comprises an amino acid sequence selected from SEQ ID NO:7-9. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO:7-9. In some embodiments, the peptide comprises an amino acid sequence of SEQ ID NO: 10. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO: 10. In some embodiments, the peptide comprises an amino acid sequence of SEQ ID NO: 11 or 12. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO: 11 or 12. In some embodiments, the peptide comprises an amino acid sequence selected from SEQ ID NO: 13-15. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO: 13-15. In some embodiments, the peptide comprises an amino acid sequence selected from SEQ ID NO: 16-22. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO: 16-22. In some embodiments, the peptide comprises an amino acid sequence selected from SEQ ID NO:23-29. In some embodiments, the peptide comprises an amino acid sequence with at least 80, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% sequence identity to SEQ ID NO:23-29. In some embodiments, the peptide comprises at least 10 amino acids. In some embodiments, the peptide comprises at least 6 contiguous amino acids of one of SEQ ID NO:7-29. In some embodiments, the peptide comprises at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18 (or any derivable range therein) contiguous amino acids of SEQ ID NOS: 1-29. In some embodiments, the peptide consists of 10 amino acids. In some embodiments, the peptide consists of 8, 9, 10, 11, 12, 13, or 14 amino acids. In some embodiments, the peptide is less than 20 amino acids in length. In some embodiments, the peptide is less than 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, or 6 amino acids (or any derivable range therein) in length. In some embodiments, the peptide is modified. In some embodiments, the modification comprises conjugation to a molecule. In some embodiments, the molecule comprises an antibody, a lipid, an adjuvant, or a detection moiety.

[0026] In some embodiments, the compositions of the disclosure are formulated as a vaccine. In some embodiments, the compositions and methods of the disclosure provide for prophylactic therapies to prevent brain cancer. In some embodiments, the compositions and methods of the disclosure provide for therapeutic therapies to treat existing cancers, such as for the treatment of patients with a brain tumor. In some embodiments, the composition further comprises an adjuvant. Adjuvants are known in the art and include, for example, TLR agonists and aluminum salts. Other adjuvants include IL-1, IL-2, IL-4, IL-7, IL-12, -interferon, GMCSP, BCG, aluminum hydroxide, MDP compounds, such as thur-MDP and nor-MDP, CGP (MTP- PE), lipid A, and monophosphoryl lipid A (MPL). Exemplary adjuvants may include complete Freund’s adjuvant (a non-specific stimulator of the immune response containing killed Mycobacterium tuberculosis), incomplete Freund’s adjuvants, and/or aluminum hydroxide adjuvant. Further embodiments of adjuvants include amorphous aluminum hydroxyphosphate sulfate (AAHS), aluminum hydroxide, aluminum phosphate, potassium aluminum sulfate, the combination of monophosphoryl lipid A (MPL) and aluminum salt, oil in water emulsion composed of squalene, a liposomal formulation of MPL and QS-21 (a natural compound extracted from the Chilean soapbark tree), and cytosine phosphoguanine (CpG), a synthetic form of DNA that mimics bacterial and viral genetic material.

[0027] In some embodiments, the dendritic cell comprises a mature dendritic cell. In some embodiments, the cell is a cell with an HLA type selected from HLA-A, HLA-B, or HLA-C. In some embodiments, the cell is a cell with an HLA type selected from HLA-A*02:01, HLA-A*03:01, HLA-A*23:01, HLA-A*68:02, HLA-B*07:05, HLA-B*18:01, HLA-B*40:01, HLA-C *03: 03, HLA-C*14:02, or HLA-C* 15:02.

[0028] In some embodiments the methods of the disclosure further comprise screening the dendritic cell for one or more cellular properties. In some embodiments, the method further comprises contacting the cell with one or more cytokines or growth factors. In some embodiments, the one or more cytokines or growth factors comprises GM-CSF. In some embodiments, the cellular property comprises cell surface expression of one or more of CD86, HLA, and CD14. In some embodiments, the dendritic cell is derived from a CD34+ hematopoietic stem or progenitor cell.

[0029] In some embodiments, the dendritic cell is derived from a peripheral blood monocyte (PBMC). In some embodiments, the dendritic cells is isolated from PBMCs. In some embodiments, the dendritic cells are cells in which the DCs are derived from are isolated by leukaphereses.

[0030] In some embodiments, the composition further comprises one or more cytokines, growth factors, or adjuvants. In some embodiments, the composition comprises GM-CSF. In some embodiments, the peptide and GM-CSF are linked. In some embodiments, the composition is determined to be serum-free, mycoplasma-free, endotoxin-free, and sterile. In some embodiments, the peptide is on the surface of the dendritic cell. In some embodiments, the peptide is bound to a MHC molecule on the surface of the dendritic cell. In some embodiments, the composition is enriched for dendritic cells expressing CD86 on the surface of the cell. In some embodiments, the dendritic cell is derived from a CD34+ hematopoietic stem or progenitor cell. In some embodiments, the dendritic cell is derived from a peripheral blood monocyte (PBMC). In some embodiments, the dendritic cells or cells in which the DCs are derived are isolated by leukaphereses.

[0031] In some embodiments of the disclosure, the cell comprises a stem cell, a progenitor cell, or a T cell. In some embodiments, the cell comprises a hematopoietic stem or progenitor cell, a T cell, or an induced pluripotent stem cell (iPSC).

[0032] In some embodiments, the method comprises administering a cell or a composition comprising a cell and wherein the cell comprises an autologous cell. In some embodiments, the cell comprises a non-autologous cell.

[0033] Throughout this application, the term “about” is used according to its plain and ordinary meaning in the area of cell and molecular biology to indicate that a value includes the standard deviation of error for the device or method being employed to determine the value. [0034] The use of the word “a” or “an” when used in conjunction with the term “comprising” may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.”

[0035] As used herein, the terms “or” and “and/or” are utilized to describe multiple components in combination or exclusive of one another. For example, “x, y, and/or z” can refer to “x” alone, “y” alone, “z” alone, “x, y, and z,” “(x and y) or z,” “x or (y and z),” or “x or y or z.” It is specifically contemplated that x, y, or z may be specifically excluded from an embodiment.

[0036] The words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”), “characterized by” (and any form of including, such as “characterized as”), or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.

[0037] The compositions and methods for their use can “comprise,” “consist essentially of,” or “consist of’ any of the ingredients or steps disclosed throughout the specification. The phrase “consisting of’ excludes any element, step, or ingredient not specified. The phrase “consisting essentially of’ limits the scope of described subject matter to the specified materials or steps and those that do not materially affect its basic and novel characteristics. It is contemplated that embodiments described in the context of the term “comprising” may also be implemented in the context of the term “consisting of’ or “consisting essentially of.”

[0038] It is specifically contemplated that any limitation discussed with respect to one embodiment of the invention may apply to any other embodiment of the invention. Furthermore, any composition of the invention may be used in any method of the invention, and any method of the invention may be used to produce or to utilize any composition of the invention. Aspects of an embodiment set forth in the Examples are also embodiments that may be implemented in the context of embodiments discussed elsewhere in a different Example or elsewhere in the application, such as in the Summary of Invention, Detailed Description of the Embodiments, Claims, and description of Figure Legends.

[0039] Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

[0041] FIG. 1A-C provides a process to generate antigenic peptides utilizing RNA-seq data derived from neoplastic tissue in accordance with an embodiment.

[0042] FIG. 2 provides a process to generate antigenic peptides utilizing RNA-seq data and mass spectrometry data derived from neoplastic tissue in accordance with an embodiment. [0043] FIG. 3 provides an example of process Isoform peptides from RNA splicing for Immunotherapy target Screening (IRIS) that can be used to identify peptides for T cell receptor and chimeric antigen receptor therapies in accordance with an embodiment. Shown is the Workflow for IRIS, integrating computational modules, large-scale reference RNA-Seq panels, and dedicated statistical testing programs. IRIS has three main modules: RNA-Seq data processing (top), in silico screening (middle), and TCR/CAR-T target prediction (bottom). The prediction module includes an option for proteo-transcriptomics integration of RNA-Seq and MS data.

[0044] FIG. 4. IRIS: A big data-powered platform for discovering AS-derived cancer immunotherapy targets. Stepwise results of IRIS to identify AS-derived cancer immunotherapy targets from 22 GBM samples (top). Identified skipped-exon (SE) events from the IRIS data-processing module were screened against tissue-matched normal panel (‘Normal Brain’) to identify tumor-associated events (‘Primary’ set), followed by tumor panel and normal panel to identify tumor-recurrent and tumor-specific events, respectively (‘Prioritized’ set). After constructing splice-junction peptides of tumor isoforms, TCR/CAR-T targets were predicted. As an illustrative example, IRIS readouts for prioritized candidate TCR targets are shown (bottom). Violin plots (left) show PSI values of individual AS events across GBM (‘GBM-input’) versus three reference panels. Dots (middle) summarize screening results. Darker-colored dots indicate stronger tumor features (association/recurrence/specificity) versus each reference panel. FC is estimated fold change of tumor isoform’s proportion in GBM versus tissue-matched normal panel (‘Brain’). Predicted HLA-epitope binding (right) is output of prediction module. Preferred features for immunotherapy targets in this study are shown in blue. Amino acids at splice junctions in epitopes are underlined. ‘Best HLA’ is HLA type with best predicted affinity (median ICso) for given splice-junction epitope. ‘#Pt. w/HLA’ is number of patients with HLA type(s) predicted to bind to a given epitope. Three epitopes in TMEM62 and PLA2G6 (blue) were predicted to bind to common HLA types (HLA-A02:01 and HLA-A03:01) and were selected for experimental validation. Figure discloses SEQ ID NOS 7, 9, 10, 12, 11, 13, 15, 21, 22, 27, and 29, respectively, in order of appearance. [0045] FIG. 5A-C. IRIS-predicted AS-derived TCR targets recognized by CD3 ⁺ CD8 ⁺ T cells in tumors and peripheral blood from patients, a, Summary of dextramer-based validation of IRIS-predicted AS-derived epitopes. PBMCs and/or TILs from four HLA-A03 and two HLA-A02 patients were tested for recognition of IRIS-predicted epitopes. Within each HLA type, epitopes are listed by order of tumor specificity (high to low) versus normal panel (11 normal nonbrain tissues). Reactivity (‘Positive’, ‘Marginal’, or ‘Negative’) in assay was evaluated as percentage of dextramer-labeled cells among PBMCs/TILs (>0.1%, 0.01%-0.1%, or <0.01% of CD3 ⁺ CD8 ⁺ cells, respectively) after subtracting negative control (nonhuman peptide). 'Dextramer assay summary' was determined by the mean percent reactivity of CD3 ⁺ CD8 ⁺ cells across individual tests b, Flow cytometric analysis showing that ex vivo- expanded TILs from one HLA-A03 patient (LB2867) contained T cells that recognized epitope KIGRLVTRK (SEQ ID NO:29). Rows correspond to cells that recognize APC- and PE-labeled dextramers (top), only PE-labeled dextramers (middle), or only APC-labeled dextramers (bottom). Percentages of epitope-specific cells are shown c, Immune profiling results revealing immune repertoire composition of KIGRLVTRK (SEQ ID NO:29)-specific T cells from one patient (LB2867). The scRNA-Seq assay was performed on sorted KIGRLVTRK (SEQ ID NO:29)-specific T cells, whereas pairSEQ and immunoSEQ assays captured TCR clones from bulk TIL RNAs of same patient. Table (left) lists seven most abundant T-cell clones from scRNA-Seq, with percentages of matching CDR3 sequences from TCR b chains. *For pairSEQ and immunoSEQ, percentages are the best frequencies of matching TCR pair or b-chain clones. The 3D scatterplot (right) shows that these approaches converged on three dominant TCR clones. For comparison, the same epitope in the table and 3D scatterplot are identified by use of the same color for the sequence (table) and text box (plot). Figure discloses SEQ ID NOS 29, 557, 22, 556, 27, 227, 62, 30-43, 33, 31, and 35, respectively, in order of appearance.

[0046] FIG. 6A-C. RNA-Seq big-data reference panels in IRIS, a, Exon-based principal component analysis (PCA) of RNA-Seq data of 9,662 samples from 53 normal tissues from the GTEx consortium. Samples from the same histological site are grouped by color. Samples from different subregions of the same histological site are differentiated by different shapes b, Summary of 53 normal tissues from the GTEx consortium. Data for all 53 tissues are available to IRIS users as a reference panel of normal tissues. In the present study, 11 selected vital tissues (heart, skin, blood, lung, liver, nerve, muscle, spleen, thyroid, kidney, and stomach) were used for the ‘normal panel’. ‘Events Selected’ represent AS events with an average count > 10 reads for the sum of all splice junctions across all samples in that tissue c, Summary of the tumor reference panel (TCGA tumor samples relevant to GBM). ‘Events Selected’ represent AS events with an average count > 10 reads for the sum of all splice junctions across all samples in that tumor type.

[0047] FIG. 7A-B. Identification of AS events that are prone to measurement errors due to technical variances across big-data reference panels, a, Computational workflow to create a ‘blacklist’ of error-prone AS events. Normal 76-bp RNA-Seq reads were artificially trimmed to 48 bp. RNA-Seq files (76- and 48-bp) were aligned by using two different aligners (Tophat and STAR). AS events were quantified by rMATS-turbo. AS events with statistically significant differences in PSI values among RNA-Seq datasets with distinct technical conditions were identified and included in a blacklist b, Scatter plots comparing PSI values of GTEx normal brain RNA-Seq data estimated under distinct technical conditions (read lengths: 48- and 76-bp, aligners: STAR and Tophat). ‘Significantly different’ AS events were defined as those with significantly different PSI values (p < 0.05, abs(A\ _|/ ) > 0.05 from paired /-test). [0048] FIG. 8A-B. CAR-T target prediction by IRIS, a, Computational workflow to annotate protein extracellular domain (ECD)-associated AS events for CAR-T target discovery b, Five examples of IRIS-identified AS-derived CAR-T targets for 22 GBM samples. Position of the ECD in amino acid (aa) sequence was obtained from UniProtKB.

[0049] FIG. 9A-E. Proteo-transcriptomic analysis of HLA presentation of AS-derived epitopes in normal and tumor cell lines, a, Proteo-transcriptomics workflow adopted by IRIS to discover splice-junction peptides in MS datasets. IRIS inputs MS data (right), such as whole cell proteomics, surfaceomics, or immunopeptidomics (HLA peptidomics) data. RNA-Seq- based custom proteome library is constructed and searched using MSGF+. b, Summary of HLA presentation of AS-derived epitopes in JeKo-1 (lymphoma) and B-LCL (normal) cell lines. Peptide-spectrum matches (‘PSMs’) and ‘Unique peptides’ are provided by MSGF+ with a target-decoy FDR of 5%. ‘Predicted AS epitopes’ are generated by the IRIS prediction module, which utilizes IEDB predictors. AS epitopes that are predicted by IRIS and detected in the MS data are considered ‘MS-validated AS epitopes’ . c, Percentage of IRIS-predicted AS-derived epitopes among all MS-detected peptides. Graph shows the percentage of all MS- detected peptides that are IRIS-predicted AS-derived epitopes (y-axis) as a function of the MSGF+ target-decoy FDR (x-axis). d, Preferential detection of high-affinity AS-derived peptides in MS data. Graph shows the number of AS-derived peptides detected in JeKo-1 MS data (y-axis) as a function of the MSGF+ target-decoy FDR (x-axis). Peptides with high (ICso < 500 nM; Pred+, orange) and low (ICso > 500 nM; Pred-, grey) predicted HLA binding affinities are shown e, Heatmap depiction of distribution of AS-derived epitopes in JeKo-1 MS immunopeptidome, as a function of predicted HLA binding affinity and transcript expression level. AS-derived peptides are binned by the corresponding transcripts’ expression levels and IEDB-predicted binding affinity scores. Heatmap is colored from red (high) to yellow (90 ^th percentile) to blue (low), reflecting the proportion of IRIS-predicted AS-derived epitopes that are MS-detected in each bin.

[0050] FIG. 10A-D. Consistent distributions of high-frequency TCR clones in one patient’s TIL population revealed by multiple TCR sequencing approaches, a, Scatter plot comparing scRNA-Seq and bulk TIL pairSEQ for detection of high-frequency TCR clones. Graph shows frequency detected from bulk TIL samples using pairSEQ (y-axis) and scRNA- Seq on dextramer-positive sorted TIL samples (x-axis). As a complementary validation of scRNA-Seq, clonotypes from pairSEQ were matched to scRNA-Seq results by either CDR3 pairs or b chains, whichever matched best. The 10 most abundant TCR clones by scRNA-Seq that overlapped with clones detected by bulk TIL pairSEQ are circled b, Table showing CDR3 amino acid sequences of the 10 most abundant TCR clones detected by scRNA-Seq and their corresponding detection frequencies by bulk TIL pairSEQ. As a complementary validation of scRNA-Seq, clonotypes from pairSEQ were matched to scRNA-Seq results by either CDR3 pairs or b chains, whichever matched best c, Scatter plot comparing bulk TIL immunoSEQ and bulk TIL pairSEQ for detection of high-frequency TCR clones. Graph shows frequency detected from bulk TIL samples using immunoSEQ (y-axis) and pairSEQ (x-axis). Clonotypes from immunoSEQ were matched to pairSEQ results by the best CDR3 b chains. Four high- frequency overlapping clones from both methods are circled and color-coded, with b-chain CDR3 amino acid sequences and frequencies by each method shown in boxes d, Scatter plot comparing scRNA-Seq and bulk TIL immunoSEQ for detection of high-frequency TCR clones. Graph shows frequency detected from bulk TIL samples using immunoSEQ (y-axis) and scRNA-Seq on dextramer-positive sorted TIL samples (x-axis). As a complementary validation of scRNA-Seq, clonotypes from immunoSEQ were matched to scRNA-Seq results by the best CDR3 b chains. Three high-frequency overlapping clones from both methods are circled and color-coded, with b-chain CDR3 amino acid sequences and frequencies by each method shown in boxes. Figure discloses SEQ ID NOS 30, 32, 34, 36, 38, 40, 42, 714, 715, 581, 746, 31, 33, 35, 37, 39, 41, 43, 572, 574, and 580 (in order of columns) and 558, 31, 33, 39, 33, 35, and 31, respectively, in order of appearance.

[0051] FIG. 11: IRIS: A big data-powered platform for discovering AS-derived cancer immunotherapy targets. Stepwise results of IRIS to identify AS-derived cancer immunotherapy targets from 22 GBM samples (top). Identified skipped-exon (SE) events from the IRIS data-processing module were screened against tissue-matched normal panel (‘Normal Brain’) to identify tumor-associated events (‘Primary’ set), followed by tumor panel and normal panel to identify tumor-recurrent and tumor-specific events, respectively (‘Prioritized’ set). After constructing splice-junction peptides of tumor isoforms, TCR/CAR-T targets were predicted. As an illustrative example, IRIS readouts for prioritized candidate TCR targets are shown (bottom). Violin plots (left) show PSI values of individual AS events across GBM (‘GBM-input’) versus three reference panels. Dots (middle) summarize screening results. Darker-colored dots indicate stronger tumor features (associati on/recurrence/ specificity) versus each reference panel. FC is estimated fold change of tumor isoform’s proportion in GBM versus tissue-matched normal panel (‘Brain’). Predicted HLA-epitope binding (right) is output of prediction module. Preferred features for immunotherapy targets in this study are shown in blue. Amino acids at splice junctions in epitopes are underlined. ‘Best HLA’ is HLA type with best predicted affinity (median IC50) for given splice-junction epitope. ‘#Pt. w/HLA’ is number of patients with HLA type(s) predicted to bind to a given epitope. Figure discloses SEQ ID NOS: 1371, 1396, 1397, 1380, 1398, 1399, 1400, 1401, 1402, 21, and 22, respectively, in order of appearance.

DETAILED DESCRIPTION OF THE INVENTION

[0052] Aberrant alternative splicing (AS) is widespread in cancer, leading to an extensive but largely unexploited repertoire of potential immunotherapy targets. This disclosure describes computational platforms leveraging large-scale cancer and normal transcriptomics data to discover AS-derived tumor antigens for T-cell receptor (TCR) and chimeric antigen receptor T-cell (CAR-T) therapies. Applying AS identifying computational platforms to RNA-Seq data from 22 glioblastomas resected from patients, the inventors identified candidate epitopes and validated their recognition by patient T cells, demonstrating platforms’ utility for expanding targeted cancer immunotherapy.

1. Identification and synthesis of neoplastic tissue antigens

[0053] An embodiment of a process to identify and synthesize neoplastic tissue antigens is illustrated in FIG. 1A. This embodiment is directed to utilizing RNA-seq data derived from neoplastic tissue to identify AS events, especially in neoplastic tissue, which in turn is utilized to identify antigens derived from the AS events. Various comparative and statistical methods are utilized to rank AS events and the antigens. [0054] Process 100 can begin with identifying (101) AS event in RNA seq data derived from neoplastic tissue. AS events include (but are not limited to) exon skipping, an alternative 3’ splice site, an alternative 5’ splice site, and intron retention. For AS events identification applications described within, RNA sequencing provides a facile method to obtain sequence data, as it is typically abundant in the biological source, can be easily sequenced by known methods, readily available in numerous public and private databases, has intronic sequences already removed, and many exon reference databases exist for post-sequencing data analysis. [0055] The source of RNA sequence data can be derived de novo (i.e., from biological tissue), or from a public or private database. Several methods can be utilized to derive RNA sequence data from biological tissue (or a collection of biological tissues). Generally, RNA molecules are extracted from tissue, prepped to be sequenced, and then run on a sequencer. For example, RNA can be extracted from a human tissue source, then prepped into a sequence library, and sequenced on a next-generation sequencing platform, such as those manufactured by Illumina, Inc. (San Diego, CA). Neoplastic tissue sources include (but are not limited to) tumor biopsy, nodal biopsy, surgical resection, and liquid/soft biopsies. Liquid and soft biopsies can be used to collect circulating neoplastic cells or cell-free nucleic acids, and include (but not limited to) blood, plasma, lymph, cerebral spinal fluid, urine, and stool. In many embodiments, biopsies are extracted from patients having been diagnosed with a particular neoplasm.

[0056] In some embodiments, RNA sequence data can be derived from an available database. For example, transcriptome data can be obtained from the National Center for Biotechnology Information (NCBI), Reference Sequence Database (RefSeq), Genotype-Tissue Expression Portal (GTEx), and The Cancer Genome Atlas Program (TCGA) databases. Sequence data could be in any appropriate sequence read format, including (but not limited to) single or paired-end reads.

[0057] Any appropriate neoplastic tissue can be analyzed, including (but not limited to) acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), anal cancer, astrocytomas, basal cell carcinoma, bile duct cancer, bladder cancer, breast cancer, Burkitt’s lymphoma, cervical cancer, chronic lymphocytic leukemia (CLL) chronic myelogenous leukemia (CML), chronic myeloproliferative neoplasms, colorectal cancer, diffuse large B-cell lymphoma, endometrial cancer, ependymoma, esophageal cancer, esthesioneuroblastoma, Ewing sarcoma, fallopian tube cancer, follicular lymphoma, gallbladder cancer, gastric cancer, gastrointestinal carcinoid tumor, hairy cell leukemia, hepatocellular cancer, Hodgkin lymphoma, hypopharyngeal cancer, Kaposi sarcoma, Kidney cancer, Langerhans cell histiocytosis, laryngeal cancer, leukemia, liver cancer, lung cancer, lymphoma, melanoma, Merkel cell cancer, mesothelioma, mouth cancer, neuroblastoma, non-Hodgkin lymphoma, non-small cell lung cancer, osteosarcoma, ovarian cancer, pancreatic cancer, pancreatic neuroendocrine tumors, pharyngeal cancer, pituitary tumor, prostate cancer, rectal cancer, renal cell cancer, retinoblastoma, skin cancer, small cell lung cancer, small intestine cancer, squamous neck cancer, T cell lymphoma, testicular cancer, thymoma, thyroid cancer, uterine cancer, vaginal cancer, and vascular tumors.

[0058] In many embodiments, RNA is processed before analysis. Any appropriate method can be used to process sequence data. For example, the sequence data can be trimmed with the publicly available TrimGalore

(http://www.bioinformatics.babraham.ac.uk/projects/trim_g alore/) or cutAdapt

(https://cutadapt.readthedocs.io/en/stable/) methods, which remove adapter sequences and trim poor-quality bases. Mapping can be performed with any appropriate annotated genome, such as, for example, UCSC’s hgl9

(http://support.illumina.com/sequencing/sequencing_softwa re/igenome.html) and alignment tool, such as, for example, Bowtie2 (http://bowtie-bio.sourceforge.net/bowtie2/index.shtml), TopHat (https://ccb.jhu.edu/software/tophat/index.shtml), and STAR

(https://github.com/alexdobin/STAR). Genes and their exons can be identified and their relative expression level determined. For instance, quantification of gene expression and AS events can be determined by GENCODE package (Harrow, J. et al. Genome Res. 22, 1760- 1774 (2012), the disclosure of which is incorporated herein by reference). Potential false positive events can be removed by using a blacklist of AS events whose quantification across diverse RNA-Seq datasets is error-prone due to technical variances such as read length. Based on expression levels of exons, in several embodiments, splice-junction counts are determined by an appropriate method, such as the rMATS package (S. Shen, et al. Proc. Natl. Acad. Sci. Ill, E5593-E5601 (2014), the disclosure of which is incorporated herein by reference). Splice- junction counts can be utilized to find putative skipped exons, included exons, alternative 3’ splice sites, alternative 5’ splice sites, and/or retained introns in the sequencing result. In some embodiments, measurements of AS events, including splice junction count and percent- spliced-in (PSI) metric, are computed. Processing of the data will be dependent on the users’ goal, and thus adaptable to the results desired. Although only a few methods of trimming, processing, and mapping sequence data are disclosed, it should be understood many more methods exist and are covered by various embodiments of the invention.

[0059] Returning back to FIG. 1, reference panels of AS events in healthy matched tissue and other tissues of the body are constructed or retrieved (103). In many embodiments, healthy matched tissue is the same tissue origin as the neoplastic tissue, but has not transformed into a neoplasm. For instance, in some embodiments, healthy matched tissue of glioblastoma (GBM) is brain tissue. In some embodiments, other tissues of the body include any tissue that is not the source of the neoplasm. Tissues of single individual or tissue of collections of individuals can be analyzed. Analysis can be done on RNA-seq data derived from a single individual or a collection of individuals. For each non-neoplastic tissue to be analyzed, the RNA-seq data can be utilized to determine expression levels of exons, which can be utilized to determine splice- junction counts and putative skipped and/or included exons. These data can be stored to be utilized for comparisons with the neoplastic tissue of interest to be analyzed.

[0060] In a number of embodiments, utilizing the panel of AS events in healthy match tissue and the AS events of the neoplastic tissue, the relative abundance of AS events can be computed. The PSI is the percent of a particular isoform included in an AS event in the neoplastic tissue or the healthy matched or other heathy tissue and can be utilized for any type of AS event, including (but not limited to) exon skipping, an alternative 3’ spice site, an alternative 5’ spice site, and intron retention. Generally, a high PSI value in the neoplastic tissue, as compared to healthy match tissue, indicates including of the genetic material and a low PSI value in the neoplastic tissue indicates the neoplastic tissue spices out the genetic material. For example, in regards to exon-skipping, neoplastic tissue isoforms can be either an exon-skipped isoform (low PSI) or an exon-included isoform (high PSI), as compared to the tissue-matched normal panel.

[0061] In addition, a reference panel of AS events of a collection of similar neoplasm types is constructed or retrieved (105). Similar neoplasm types can be neoplasms having the same tissue origin. For instance, to construct a reference panel for GBM, other brain tumor sequencing data can be utilized, including (but not limited to) other samples of GBM and/or lower-grade glioma. The RNA-seq data of the collection of samples can be utilized to determine splice-junction counts and putative skipped exons, included exons, alternative 3’ splice sites, alternative 5’ splice sites, and/or retained introns. These data can be stored to be utilized for comparisons with the neoplastic tissue of interest to be analyzed.

[0062] Process 100 also detects (107) putative recurrent AS event candidates. In some embodiments, recurrent AS event candidates are determined comparing relative abundance of alternative isoforms (Fig. IB). In some embodiments, putative recurrent AS event candidates are determined by comparing prevalence of alternative isoforms (Fig. 1C). In some embodiments, recurrent AS event candidates are determined comparing relative abundance and comparing prevalence of alternative isoforms. [0063] As depicted in Fig. IB, process 100B determines (107B) the relative abundance of the alternative isoforms by determining the relative expression of the alternative isoforms in the neoplastic tissue, as compared to the relative expression of the alternative isoforms in the panels of reference tissues (e.g., healthy matched tissue, other tissues, and similar neoplasm types). In many embodiments, statistical differential testing is utilized to determine the significance of a putative AS event candidate, as determined by the relative expression of an AS event. In some embodiments, a significant AS event is one that is a significant as determined by the resulting p-value of a statistical test comparing neoplastic tissue and a reference tissue. Statistical tests include (but are not limited to) parametric tests (e.g. two-sided/one sided t-test) and non- parametric tests (e.g. Mann-Whitney U test). In some embodiments, the difference of PSI values between comparing neoplastic tissue and reference tissue is utilized to identify significant AS events. In particular embodiments, a neoplastic AS event is significant when it satisfies the following: 1) a significant p-value from a statistical test (e.g., p < 0.01), and 2) a threshold of PSI value difference (e.g., h1)8(DY) > 0.05).

[0064] In some embodiments, significance testing (e.g., /-tests) and equivalence testing (e.g., two one-sided /-tests (TOSTs)) is used to identify neoplasm-associated, neoplasm-recurrent, and neoplasm-specific AS events in group comparisons. Specifically, AS events can be compared with a reference tissue (e.g., healthy matched tissue) to identify neoplastic tissue- associated AS events, with other tissue types to determine neoplastic tissue-specificity of AS events, and with similar neoplasm types to evaluate recurrence of AS events. In some embodiments, an AS event is considered significantly different when it meets two requirements: (1) a significant p-value from the statistical test (defaults: p < 0.01 for significance testing; p < 0.05 for equivalence testing), and (2) a threshold of PSI value difference (default: abs(A\ _|/ )>0.05 for significance testing; abs(A\ _|/ )<0.05 for equivalence testing).

[0065] In several embodiments, an AS event is defined as neoplasm-recurrent by comparing a panel of neoplastic tissue data with a panel of reference tissue (e.g., healthy matched tissue). For instance, in some embodiments, a neoplasm-recurrent AS event is identified when 1) a significant p-value from the statistical test in the same direction as the corresponding neoplasm- associated AS event (e.g., p < 0.01/number of neoplasm-associated events;), and 2) a threshold of PSI value difference (default: abs(A'F) > 0.05). In some embodiments, a Bonferroni correction is applied wen determining p-value from the statistical test, which may be helpful due to large sample sizes in reference panels. [0066] Additionally, in some embodiments, a threshold of the number of significant comparisons against groups in the normal or neoplasm reference panel is used to determine whether AS-derived antigens are neoplasm-specific or neoplasm-recurrent. In various embodiments, the neoplasm panel data and/or reference panel data includes multiple individual groups (e.g., tissue types) and a threshold of the number of significant comparisons against groups in the normal or tumor reference panel is used to determine whether AS-derived antigens are tumor-specific or tumor-recurrent. For each AS event, various embodiments utilize a definition that the ‘neoplasm isoform’ is the isoform that is more abundant in neoplastic tissue than in the tissue-matched normal panel. Optionally, in some embodiments, to rank or filter targets, the ‘fold-change (FC) of neoplasm isoform’ is estimated as the FC of the neoplasm isoform’s proportion in neoplasms compared to the tissue-matched normal panel. Furthermore, in some embodiments, targets are screened for a specific patient sample through a ‘personalized mode’ . A personalized mode uses an outlier detection approach, combining a modified Tukey’s rule and a threshold of PSI value difference of >5%.

[0067] As depicted in Fig. 1C, process lOOC determines (107C) the prevalence of the alternative isoforms by determining the number of samples expressing the alternative isoform within a neoplastic tissue panel, as compared to the number of samples expressing the alternative isoform within the panels of reference tissues (e.g., healthy matched tissue, other tissues, and similar neoplasm types). In some of embodiments, a sample is considered to express a particular alternative isoform if the number of uniquely mapped junction read counts from RNA-seq data is greater than or equal to a junction count threshold.

[0068] Prevalence screening refers to the comparison the prevalence of a splice junction in a panel of neoplasm samples to one or more reference tissue samples. Specifically, in some embodiments, neoplasm samples of interest or related neoplasm samples, which can be selected from a neoplasm reference panel or other resource, are compared to reference tissue samples (e.g., tissue— matched normal samples or other normal tissue samples). In some embodiments, statistical tests (e.g., Fisher's exact test or chi-squared test) are employed to evaluate the difference of splice junction prevalence between the two groups in comparison. As a result, this allows identification of splice junctions prevalently expressed in neoplasm samples that are less observed in reference tissues. In some embodiments, to avoid false positive results by solely using read counts from RNA-seq, the same junction count information is used to calculate PSI-values and perform a relative abundance (PSI) based screening in parallel (see Fig. IB). Employment of prevalence based methods has some advantages. For example, for annotated and unannotated splice junctions, this approach offers additional knowledge for prioritization. Furthermore, this approach detects unannotated splice junctions derived from novel splice sites without the need to rebuild the splice graph. This allows for the evaluation of both junction prevalence and relative abundance for confident detection of neoplasm-specific splicing events.

[0069] Returning back to Fig. 1 A, peptide epitopes derived from nucleotides that span across the AS event of each isoform of interest are determined (109). In a number of embodiments, to obtain protein sequences of AS-derived neoplasm isoforms, peptide sequences are generated by translating splice-junction sequences into amino-acid sequences. In some embodiments, splice-junction sequences are translated into amino-acid sequences using known ORFs from the UniProtKB database (www.uniprot.org). In some embodiments, splice-junction sequences are translated into amino-acid sequences for each potential open reading frame (i.e., the three open reading frames dependent on triple nucleotide codon window), which is useful for isoform junction derived from alternative and/or novel splice sites. Within each AS event, the splice- junction peptide sequence for the neoplasm isoform can be compared to that of the alternative normal isoform, to ensure that the neoplasm isoform splice junction produces a distinct peptide. It is noted that a single splice junction can give rise to multiple putative epitopes with distinct peptide sequences

[0070] Process 100 also predicts (111) HLA binding affinity and/or identifies targetable extracellular peptides by TCR and/or chimeric antigen receptors. For TCR target prediction, a computational package can be employed which uses RNA-Seq data to characterize HLA class I alleles for each tumor sample to identify putative epitopes. In some, embodiments, the seq2HLA is used for TCR epitope identification (Boegel, S. et al. Genome Med. 4, 102 (2012), the disclosure of which is incorporated herein by reference). In addition, a computational package can predict the HLA binding affinities of candidate epitopes (e.g., the IEDB API from Vita, R. et al. Nucleic Acids Res. 43, D405-D412 (2015), the disclosure of which is herein incorporated by reference). The IEDB ‘recommended’ mode runs several prediction tools to generate multiple predictions of binding affinity, which can be summarized by a median ICso value. In some embodiments, a threshold of median(IC5o) < 500 nM denotes a positive prediction for an AS-derived TCR target, but any appropriate binding affinity can be utilized. [0071] For CAR-T cell target prediction, AS-derived tumor isoforms can be mapped to known protein extracellular domains (ECDs) to identify potential candidates for CAR-T cell therapy. Protein cellular localization information can be retrieved from the UniProtKB database (www.uniprot.org). To retrieve ECD information from the UniProtKB database, a search for the term ‘extracellular’ in topological annotation fields can be performed, including ‘TOPO DOM’, ‘TRANSMEM’, and ‘REGION’, in the flat file. In addition, BLAST (https://blast.ncbi.nlm.nih.gov/) can be used to map individual exons in the gene annotation to proteins with topological annotations. Furthermore, the BLAST result can be parsed to create annotations of the mapping between exons and ECDs in proteins. These pre-computed annotations can be queried to search for AS-derived peptides that can be mapped to protein ECDs as potential CAR-T cell targets.

[0072] Based on the results of HLA epitopes and CAR-T cell targets, peptides of interest can be generated (113) for use as a neoplasm antigen. Peptides can be synthesized directly (e.g., solid phase synthesis) or via molecular expression utilizing an expression vector and a host production cell.

[0073] While specific examples of identifying and synthesizing neoplastic tissue antigens are described above, one of ordinary skill in the art can appreciate that various steps of the process can be performed in different orders and that certain steps may be optional according to some embodiments of the invention. As such, it should be clear that the various steps of the process could be used as appropriate to the requirements of specific applications. Furthermore, any of a variety of processes for identifying and synthesizing neoplastic tissue antigens appropriate to the requirements of a given application can be utilized in accordance with various embodiments of the invention.

[0074] Provided in FIG. 2 is a process to identify and synthesize neoplastic tissue antigenic peptides integrating results of mass spectrometry data derived from a neoplastic tissue source. Process 200 can begin by identifying (201) alternative splicing events in RNA-Seq data derived from neoplastic tissue. In a manner similar to Process 100, RNA sequence data can be derived from a biological source or a database. In addition, RNA can be processed before analysis. Any appropriate method can be used to process sequence data as described herein. Potential false positive events can be removed by using a blacklist of AS events whose quantification across diverse RNA-Seq datasets is error-prone due to technical variances such as read length. Based on expression levels of exons, in several embodiments, splice-junction counts are determined by an appropriate method, such as the rMATS package. Splice-junction counts can be utilized to find putative skipped exons, included exons, alternative 3’ splice sites, alternative 5’ splice sites, and/or retained introns in the sequencing result.

[0075] Peptide epitopes derived from nucleotides that span across the alternative splicing event of each isoform of interest is determined (203). In a number of embodiments, expression of the alternative isoforms in the neoplastic tissue compared to the panels of healthy matched tissue, other tissues, and similar neoplasm types. Generally, AS events can be compared with refrence tissue (e.g., healthy matched tissue) to identify neoplastic tissue-associated AS events, with other tissue types to determine neoplastic tissue-specificity of AS events, and with similar neoplasm types to evaluate recurrence of AS events. In some embodiments, putative splice junction candidates are determined comparing relative abundance. In some embodiments, putative splice junction candidates are determined by comparing prevalence. In some embodiments, putative splice junction candidates are determined comparing relative abundance and comparing prevalence.

[0076] Process 200 also compares (205) the peptide sequences to mass spectrometry data derived from a collection of neoplasms to identify whether various isoforms are present. In some embodiments, proteo-transcriptomic data is integrated by incorporating various types of MS data, such as whole-cell proteomics, surfaceome, or immunopeptidomics data, to validate RNA-Seq based target discovery at the protein level. Specifically, sequences of AS-derived peptides are mapped to canonical and isoform sequences of the reference human proteome (downloaded from UniProtKB). For immunopeptidomics data, fragment MS spectra can be searched against the RNA-Seq based custom proteome library with no enzyme specificity. In some embodiments, the search length is limited to 7-15 amino acids. In some embodiments, the target-decoy approach is employed to control the false discovery rate (FDR) or ‘QValue’ at 5%.

[0077] Based on the results searching MS data for hits, peptides of interest can be generated (207) for use as a neoplasm antigen. Peptides can be synthesized directly (e.g., solid phase synthesis) or via biological translation utilizing an expression vector and a host production cell. [0078] While specific examples of identifying and synthesizing neoplastic tissue antigens utilizing MS data are described above, one of ordinary skill in the art can appreciate that various steps of the process can be performed in different orders and that certain steps may be optional according to some embodiments of the invention. As such, it should be clear that the various steps of the process could be used as appropriate to the requirements of specific applications. Furthermore, any of a variety of processes for identifying and synthesizing neoplastic tissue antigens utilizing MS data appropriate to the requirements of a given application can be utilized in accordance with various embodiments of the invention.

II. Applications of antigenic peptides

[0079] Various embodiments are directed to development of and use of antigenic peptides that have been identified from neoplastic tissue. In many embodiments, antigenic peptides are produced by chemical synthesis or by molecular expression in a host cell. Peptides can be purified and utilized in a variety of applications including (but not limited to) assays to determine peptide immunogenicity, assays to determine recognition by T cells, peptide vaccines for treatment of cancer, development of modified TCRs of T cells, development of antibodies, and development of CAR-T cells to recognize extracellular peptides.

[0080] Peptides can be synthesized chemically by a number of methods. One common method is to use solid-phase peptide synthesis (SPPS). Generally, SPPS is performed by repeating cycles of alternate N-terminal deprotection and coupling reactions, building peptides from the c-terminus to the n-terminus. The c-terminus of the first amino acid is coupled the resin, wherein then the amine is deprecated and then coupled with the free acid of the second amino acid. This cycle repeats until the peptide is synthesized.

[0081] Peptides can also be synthesized utilizing molecular tools and a host cell. Nucleic acid sequences corresponding with antigenic peptides can be synthesized. In some embodiments, synthetic nucleic acids synthesized in in vitro synthesizers (e.g., phosphoramidite synthesizer), bacterial recombination system, or other suitable methods. Furthermore, synthesized nucleic acids can be purified and lyophilized, or kept stored in a biological system (e.g., bacteria, yeast). For use in a biological system, synthetic nucleic acid molecules can be inserted into a plasmid vector, or similar. A plasmid vector can also be an expression vector, wherein a suitable promoter and a suitable 3’-polyA tail is combined with the transcript sequence.

[0082] Embodiments are also directed to expression vectors and expression systems that produce antigenic peptides or proteins. These expression systems can incorporate an expression vector to express transcripts and proteins in a suitable expression system. Typical expression systems include bacterial (e.g., E. coli ), insect (e.g., SF9), yeast (e.g., S. cerevisiae ), animal (e.g., CHO), or human (e.g., HEK 293) cell lines. RNA and/or protein molecules can be purified from these systems using standard biotechnology production procedures.

[0083] Assays to determine immunogenicity and/or TCR binding can be performed. One such as is the dextramer flow cytometery assay. Generally, custom-made HLA-matched MHC Class I dextramenpeptide (pMHC) complexes are developed or purchased (Immudex, Copenhagen, Denmark). T cells from peripheral blood mononuclear cells (PBMCs) or tumor- infiltrating lymphocytes (TILs) are incubated the pMHC complexes and stained, which are then run through a flow cytometer to determine if the peptide is capable of binding a TCR of a T cell. III. Engineered T Cell Receptors

[0084] T-cell receptors comprise two different polypeptide chains, termed the T-cell receptor a (TCRa) and b (TCRP) chains, linked by a disulfide bond. These a:b heterodimers are very similar in structure to the Fab fragment of an immunoglobulin molecule, and they account for antigen recognition by most T cells. A minority of T cells bear an alternative, but structurally similar, receptor made up of a different pair of polypeptide chains designated g and d. Both types of T-cell receptor differ from the membrane-bound immunoglobulin that serves as the B- cell receptor: a T-cell receptor has only one antigen-binding site, whereas a B-cell receptor has two, and T-cell receptors are never secreted, whereas immunoglobulin can be secreted as antibody.

[0085] Both chains of the T-cell receptor have an amino-terminal variable (V) region with homology to an immunoglobulin V domain, a constant (C) region with homology to an immunoglobulin C domain, and a short hinge region containing a cysteine residue that forms the interchain disulfide bond. Each chain spans the lipid bilayer by a hydrophobic transmembrane domain, and ends in a short cytoplasmic tail.

[0086] The three-dimensional structure of the T-cell receptor has been determined. The structure is indeed similar to that of an antibody Fab fragment, as was suspected from earlier studies on the genes that encoded it. The T-cell receptor chains fold in much the same way as those of a Fab fragment, although the final structure appears a little shorter and wider. There are, however, some distinct differences between T-cell receptors and Fab fragments. The most striking difference is in the Ca domain, where the fold is unlike that of any other immunoglobulin-like domain. The half of the domain that is juxtaposed with the Ob domain forms a b sheet similar to that found in other immunoglobulin-like domains, but the other half of the domain is formed of loosely packed strands and a short segment of a helix. The intramolecular disulfide bond, which in immunoglobulin-like domains normally joins two b strands, in a Ca domain joins a b strand to this segment of a helix.

[0087] There are also differences in the way in which the domains interact. The interface between the V and C domains of both T-cell receptor chains is more extensive than in antibodies, which may make the hinge joint between the domains less flexible. And the interaction between the Ca and Cb domains is distinctive in being assisted by carbohydrate, with a sugar group from the Ca domain making a number of hydrogen bonds to the Cb domain. Finally, a comparison of the variable binding sites shows that, although the complementarity determining region (CDR) loops align fairly closely with those of antibody molecules, there is some displacement relative to those of the antibody molecule. This displacement is particularly marked in the Va CDR2 loop, which is oriented at roughly right angles to the equivalent loop in antibody V domains, as a result of a shift in the b strand that anchors one end of the loop from one face of the domain to the other. A strand displacement also causes a change in the orientation of the nb CDR2 loop in two of the seven nb domains whose structures are known. As yet, the crystallographic structures of seven T-cell receptors have been solved to this level of resolution.

[0088] Embodiments of the disclosure relate to engineered T cell receptors. The term “engineered” refers to T cell receptors that have TCR variable regions grafted onto TCR constant regions to make a chimeric polypeptide that binds to peptides and antigens of the disclosure. In certain embodiments, the TCR comprises intervening sequences that are used for cloning, enhanced expression, detection, or for therapeutic control of the construct, but are not present in endogenous TCRs, such as multiple cloning sites, linker, hinge sequences, modified hinge sequences, modified transmembrane sequences, a detection polypeptide or molecule, or therapeutic controls that may allow for selection or screening of cells comprising the TCR.

[0089] In some embodiments, the TCR comprises non-TCR sequences. Accordingly, certain embodiments relate to TCRs with sequences that are not from a TCR gene. In some embodiments, the TCR is chimeric, in that it contains sequences normally found in a TCR gene, but contains sequences from at least two TCR genes that are not necessarily found together in nature.

[0090] In some embodiments the engineered TCRs of the disclosure comprise a variable as shown below: IV. Antibodies

[0091] Aspects of the disclosure relate to antibodies that target the peptides of the disclosure, or fragments thereof. The term “antibody” refers to an intact immunoglobulin of any isotype, or a fragment thereof that can compete with the intact antibody for specific binding to the target antigen, and includes chimeric, humanized, fully human, and bispecific antibodies. As used herein, the terms “antibody” or “immunoglobulin” are used interchangeably and refer to any of several classes of structurally related proteins that function as part of the immune response of an animal, including IgG, IgD, IgE, IgA, IgM, and related proteins, as well as polypeptides comprising antibody CDR domains that retain antigen-binding activity.

[0092] The term “antigen” refers to a molecule or a portion of a molecule capable of being bound by a selective binding agent, such as an antibody. An antigen may possess one or more epitopes that are capable of interacting with different antibodies.

[0093] The term “epitope” includes any region or portion of molecule capable eliciting an immune response by binding to an immunoglobulin or to a T-cell receptor. Epitope determinants may include chemically active surface groups such as amino acids, sugar side chains, phosphoryl or sulfonyl groups, and may have specific three-dimensional structural characteristics and/or specific charge characteristics. Generally, antibodies specific for a particular target antigen will preferentially recognize an epitope on the target antigen within a complex mixture.

[0094] The epitope regions of a given polypeptide can be identified using many different epitope mapping techniques are well known in the art, including: x-ray crystallography, nuclear magnetic resonance spectroscopy, site-directed mutagenesis mapping, protein display arrays, see, e.g., Epitope Mapping Protocols, (Johan Rockb erg and Johan Nilvebrant, Ed., 2018) Humana Press, New York, N.Y. Such techniques are known in the art and described in, e.g., U.S. Pat. No. 4,708,871; Geysen et al. Proc. Natl. Acad. Sci. USA 81:3998-4002 (1984); Geysen et al. Proc. Natl. Acad. Sci. USA 82:178-182 (1985); Geysen et al. Molec. Immunol. 23:709-715 (1986). Additionally, antigenic regions of proteins can also be predicted and identified using standard antigenicity and hydropathy plots.

[0095] The term “immunogenic sequence” means a molecule that includes an amino acid sequence of at least one epitope such that the molecule is capable of stimulating the production of antibodies in an appropriate host. The term “immunogenic composition” means a composition that comprises at least one immunogenic molecule (e.g., an antigen or carbohydrate). [0096] An intact antibody is generally composed of two full-length heavy chains and two full-length light chains, but in some instances may include fewer chains, such as antibodies naturally occurring in camelids that may comprise only heavy chains. Antibodies as disclosed herein may be derived solely from a single source or may be “chimeric,” that is, different portions of the antibody may be derived from two different antibodies. For example, the variable or CDR regions may be derived from a rat or murine source, while the constant region is derived from a different animal source, such as a human. The antibodies or binding fragments may be produced in hybridomas, by recombinant DNA techniques, or by enzymatic or chemical cleavage of intact antibodies. Unless otherwise indicated, the term “antibody” includes derivatives, variants, fragments, and muteins thereof, examples of which are described below (Sela-Culang et al., Front Immunol. 2013; 4: 302; 2013).

[0097] The term “light chain” includes a full-length light chain and fragments thereof having sufficient variable region sequence to confer binding specificity. A full-length light chain has a molecular weight of around 25,000 Daltons and includes a variable region domain (abbreviated herein as VL), and a constant region domain (abbreviated herein as CL). There are two classifications of light chains, identified as kappa (K) and lambda (l). The term “VL fragment” means a fragment of the light chain of a monoclonal antibody that includes all or part of the light chain variable region, including CDRs. A VL fragment can further include light chain constant region sequences. The variable region domain of the light chain is at the amino-terminus of the polypeptide.

[0098] The term “heavy chain” includes a full-length heavy chain and fragments thereof having sufficient variable region sequence to confer binding specificity. A full-length heavy chain has a molecular weight of around 50,000 Daltons and includes a variable region domain (abbreviated herein as VH), and three constant region domains (abbreviated herein as CHI, CH2, and CH3). The term “VH fragment” means a fragment of the heavy chain of a monoclonal antibody that includes all or part of the heavy chain variable region, including CDRs. A VH fragment can further include heavy chain constant region sequences. The number of heavy chain constant region domains will depend on the isotype. The VH domain is at the amino-terminus of the polypeptide, and the CH domains are at the carboxy -terminus, with the CH3 being closest to the — COOH end. The isotype of an antibody can be IgM, IgD, IgG, IgA, or IgE and is defined by the heavy chains present of which there are five classifications: mu (m), delta (d), gamma (g), alpha (a), or epsilon (e) chains, respectively. IgG has several subtypes, including, but not limited to, IgGl, IgG2, IgG3, and IgG4. IgM subtypes include IgMl and IgM2. IgA subtypes include IgAl and IgA2. 1. Types of Antibodies

[0099] Antibodies can be whole immunoglobulins of any isotype or classification, chimeric antibodies, or hybrid antibodies with specificity to two or more antigens. They may also be fragments (e.g., F(ab')2, Fab', Fab, Fv, and the like), including hybrid fragments. An immunoglobulin also includes natural, synthetic, or genetically engineered proteins that act like an antibody by binding to specific antigens to form a complex. The term antibody includes genetically engineered or otherwise modified forms of immunoglobulins.

[0100] The term “monomer” means an antibody containing only one Ig unit. Monomers are the basic functional units of antibodies. The term “dimer” means an antibody containing two Ig units attached to one another via constant domains of the antibody heavy chains (the Fc, or fragment crystallizable, region). The complex may be stabilized by a joining (J) chain protein. The term “multimer” means an antibody containing more than two Ig units attached to one another via constant domains of the antibody heavy chains (the Fc region). The complex may be stabilized by a joining (J) chain protein.

[0101] The term “bivalent antibody” means an antibody that comprises two antigen-binding sites. The two binding sites may have the same antigen specificities or they may be bi-specific, meaning the two antigen-binding sites have different antigen specificities.

[0102] Bispecific antibodies are a class of antibodies that have two paratopes with different binding sites for two or more distinct epitopes. In some embodiments, bispecific antibodies can be biparatopic, wherein a bispecific antibody may specifically recognize a different epitope from the same antigen. In some embodiments, bispecific antibodies can be constructed from a pair of different single domain antibodies termed “nanobodies”. Single domain antibodies are sourced and modified from cartilaginous fish and camelids. Nanobodies can be joined together by a linker using techniques typical to a person skilled in the art; such methods for selection and joining of nanobodies are described in PCT Publication No. WO2015044386A1, No. WO2010037838 A2, and Bever et ak, Anal Chem. 86:7875-7882 (2014), each of which are specifically incorporated herein by reference in their entirety.

[0103] Bispecific antibodies can be constructed as: a whole IgG, Fab'2, Fab 'PEG, a diabody, or alternatively as scFv. Diabodies and scFvs can be constructed without an Fc region, using only variable domains, potentially reducing the effects of anti -idiotypic reaction. Bispecific antibodies may be produced by a variety of methods including, but not limited to, fusion of hybridomas or linking of Fab' fragments. See, e.g., Songsivilai and Lachmann, Clin. Exp. Immunol. 79:315-321 (1990); Kostelny et al., J. Immunol. 148:1547-1553 (1992), each of which are specifically incorporated by reference in their entirety.

[0104] In certain aspects, the antigen-binding domain may be multispecific or heterospecific by multimerizing with VH and VL region pairs that bind a different antigen. For example, the antibody may bind to, or interact with, (a) a cell surface antigen, (b) an Fc receptor on the surface of an effector cell, or (c) at least one other component. Accordingly, aspects may include, but are not limited to, bispecific, trispecific, tetraspecific, and other multispecific antibodies or antigen-binding fragments thereof that are directed to epitopes and to other targets, such as Fc receptors on effector cells.

[0105] In some embodiments, multispecific antibodies can be used and directly linked via a short flexible polypeptide chain, using routine methods known in the art. One such example is diabodies that are bivalent, bispecific antibodies in which the VH and VL domains are expressed on a single polypeptide chain, and utilize a linker that is too short to allow for pairing between domains on the same chain, thereby forcing the domains to pair with complementary domains of another chain creating two antigen binding sites. The linker functionality is applicable for embodiments of triabodies, tetrabodies, and higher order antibody multimers. (see, e.g., Hollinger et al., Proc Natl. Acad. Sci. USA 90:6444-6448 (1993); Polijak et al., Structure 2:1121-1123 (1994); Todorovska et al., J. Immunol. Methods 248:47-66 (2001)). [0106] Bispecific diabodies, as opposed to bispecific whole antibodies, may also be advantageous because they can be readily constructed and expressed in E. coli. Diabodies (and other polypeptides such as antibody fragments) of appropriate binding specificities can be readily selected using phage display (WO94/13804) from libraries. If one arm of the diabody is kept constant, for instance, with a specificity directed against a protein, then a library can be made where the other arm is varied and an antibody of appropriate specificity selected. Bispecific whole antibodies may be made by alternative engineering methods as described in Ridgeway et al., (Protein Eng., 9:616-621, 1996) and Krah et al., (N Biotechnol. 39:167-173, 2017), each of which is hereby incorporated by reference in their entirety.

[0107] Heteroconjugate antibodies are composed of two covalently linked monoclonal antibodies with different specificities. See, e.g., U.S. Patent No. 6,010,902, incorporated herein by reference in its entirety.

[0108] The part of the Fv fragment of an antibody molecule that binds with high specificity to the epitope of the antigen is referred to herein as the “paratope.” The paratope consists of the amino acid residues that make contact with the epitope of an antigen to facilitate antigen recognition. Each of the two Fv fragments of an antibody is composed of the two variable domains, VH and VL, in dimerized configuration. The primary structure of each of the variable domains includes three hypervariable loops separated by, and flanked by, Framework Regions (FR). The hypervariable loops are the regions of highest primary sequences variability among the antibody molecules from any mammal. The term hypervariable loop is sometimes used interchangeably with the term “Complementarity Determining Region (CDR).” The length of the hypervariable loops (or CDRs) varies between antibody molecules. The framework regions of all antibody molecules from a given mammal have high primary sequence similarity/consensus. The consensus of framework regions can be used by one skilled in the art to identify both the framework regions and the hypervariable loops (or CDRs) which are interspersed among the framework regions. The hypervariable loops are given identifying names which distinguish their position within the polypeptide, and on which domain they occur. CDRs in the VL domain are identified as LI, L2, and L3, with LI occurring at the most distal end and L3 occurring closest to the CL domain. The CDRs may also be given the names CDR-1, CDR-2, and CDR-3. The L3 (CDR-3) is generally the region of highest variability among all antibody molecules produced by a given organism. The CDRs are regions of the polypeptide chain arranged linearly in the primary structure, and separated from each other by Framework Regions. The amino terminal (N-terminal) end of the VL chain is named FR1. The region identified as FR2 occurs between LI and L2 hypervariable loops. FR3 occurs between L2 and L3 hypervariable loops, and the FR4 region is closest to the CL domain. This structure and nomenclature is repeated for the VH chain, which includes three CDRs identified as HI, H2 and H3. The maj ority of amino acid residues in the variable domains, or Fv fragments (VH and VL), are part of the framework regions (approximately 85%). The three dimensional, or tertiary, structure of an antibody molecule is such that the framework regions are more internal to the molecule and provide the majority of the structure, with the CDRs on the external surface of the molecule.

[0109] Several methods have been developed and can be used by one skilled in the art to identify the exact amino acids that constitute each of these regions. This can be done using any of a number of multiple sequence alignment methods and algorithms, which identify the conserved amino acid residues that make up the framework regions, therefore identifying the CDRs that may vary in length but are located between framework regions. Three commonly used methods have been developed for identification of the CDRs of antibodies: Rabat (as described in T. T. Wu and E. A. Rabat, “AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY,” J Exp Med, vol. 132, no. 2, pp. 211-250, Aug. 1970); Chothia (as described in C. Chothia et al., “Conformations of immunoglobulin hypervariable regions,” Nature, vol. 342, no. 6252, pp. 877-883, Dec. 1989); and IMGT (as described in M.-P. Lefranc et al., “IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains,” Developmental & Comparative Immunology, vol. 27, no. 1, pp. 55-77, Jan. 2003). These methods each include unique numbering systems for the identification of the amino acid residues that constitute the variable regions. In most antibody molecules, the amino acid residues that actually contact the epitope of the antigen occur in the CDRs, although in some cases, residues within the framework regions contribute to antigen binding.

[0110] One skilled in the art can use any of several methods to determine the paratope of an antibody. These methods include: 1) Computational predictions of the tertiary structure of the antibody/epitope binding interactions based on the chemical nature of the amino acid sequence of the antibody variable region and composition of the epitope. 2) Hydrogen-deuterium exchange and mass spectroscopy 3) Polypeptide fragmentation and peptide mapping approaches in which one generates multiple overlapping peptide fragments from the full length of the polypeptide and evaluates the binding affinity of these peptides for the epitope. 4) Antibody Phage Display Library analysis in which the antibody Fab fragment encoding genes of the mammal are expressed by bacteriophage in such a way as to be incorporated into the coat of the phage. This population of Fab expressing phage are then allowed to interact with the antigen which has been immobilized or may be expressed in by a different exogenous expression system. Non-binding Fab fragments are washed away, thereby leaving only the specific binding Fab fragments attached to the antigen. The binding Fab fragments can be readily isolated and the genes which encode them determined. This approach can also be used for smaller regions of the Fab fragment including Fv fragments or specific VH and VL domains as appropriate.

[0111] In certain aspects, affinity matured antibodies are enhanced with one or more modifications in one or more CDRs thereof that result in an improvement in the affinity of the antibody for a target antigen as compared to a parent antibody that does not possess those alteration(s). Certain affinity matured antibodies will have nanomolar or picomolar affinities for the target antigen. Affinity matured antibodies are produced by procedures known in the art, e.g., Marks et al., Bio/Technology 10:779 (1992) describes affinity maturation by VH and VL domain shuffling, random mutagenesis of CDR and/or framework residues employed in phage display is described by Rajpal et al., PNAS. 24: 8466-8471 (2005) and Thie et al., Methods Mol Biol. 525:309-22 (2009) in conjugation with computation methods as demonstrated in Tiller et al., Front. Immunol. 8:986 (2017).

[0112] Chimeric immunoglobulins are the products of fused genes derived from different species; “humanized” chimeras generally have the framework region (FR) from human immunoglobulins and one or more CDRs are from a non-human source.

[0113] In certain aspects, portions of the heavy and/or light chain are identical or homologous to corresponding sequences from another particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is identical or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, so long as they exhibit the desired biological activity. U.S. Pat. No. 4,816,567; and Morrison et al., Proc. Natl. Acad. Sci. USA 81:6851 (1984). For methods relating to chimeric antibodies, see, e.g., U.S. Pat. No. 4,816,567; and Morrison et al., Proc. Natl. Acad. Sci. USA 81:6851-6855 (1985), each of which are specifically incorporated herein by reference in their entirety. CDR grafting is described, for example, in U.S. Pat. Nos. 6,180,370, 5,693,762, 5,693,761, 5,585,089, and 5,530,101, which are all hereby incorporated by reference for all purposes.

[0114] In some embodiments, minimizing the antibody polypeptide sequence from the non human species optimizes chimeric antibody function and reduces immunogenicity. Specific amino acid residues from non-antigen recognizing regions of the non-human antibody are modified to be homologous to corresponding residues in a human antibody or isotype. One example is the “CDR-grafted” antibody, in which an antibody comprises one or more CDRs from a particular species or belonging to a specific antibody class or subclass, while the remainder of the antibody chain(s) is identical or homologous to a corresponding sequence in antibodies derived from another species or belonging to another antibody class or subclass. For use in humans, the V region composed of CDR1, CDR2, and partial CDR3 for both the light and heavy chain variance region from a non-human immunoglobulin, are grafted with a human antibody framework region, replacing the naturally occurring antigen receptors of the human antibody with the non-human CDRs. In some instances, corresponding non-human residues replace framework region residues of the human immunoglobulin. Furthermore, humanized antibodies may comprise residues that are not found in the recipient antibody or in the donor antibody to further refine performance. The humanized antibody may also comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin. See, e.g., Jones et al., Nature 321:522 (1986); Riechmann et al., Nature 332:323 (1988); Presta, Curr. Op. Struct. Biol. 2:593 (1992); Vaswani and Hamilton, Ann. Allergy, Asthma and Immunol. 1:105 (1998); Harris, Biochem. Soc. Transactions 23; 1035 (1995); Hurle and Gross, Curr. Op. Biotech. 5:428 (1994); Verhoeyen et al., Science 239:1534-36 (1988).

[0115] Intrabodies are intracellularly localized immunoglobulins that bind to intracellular antigens as opposed to secreted antibodies, which bind antigens in the extracellular space. [0116] Polyclonal antibody preparations typically include different antibodies against different determinants (epitopes). In order to produce polyclonal antibodies, a host, such as a rabbit or goat, is immunized with the antigen or antigen fragment, generally with an adjuvant and, if necessary, coupled to a carrier. Antibodies to the antigen are subsequently collected from the sera of the host. The polyclonal antibody can be affinity purified against the antigen rendering it monospecific.

[0117] Monoclonal antibodies or “mAh” refer to an antibody obtained from a population of homogeneous antibodies from an exclusive parental cell, e.g., the population is identical except for naturally occurring mutations that may be present in minor amounts. Each monoclonal antibody is directed against a single antigenic determinant.

B. Functional Antibody Fragments and Antigen-Binding Fragments 1. Antigen-Binding Fragments

[0118] Certain aspects relate to antibody fragments, such as antibody fragments that bind to a peptide of the disclosure. The term functional antibody fragment includes antigen-binding fragments of an antibody that retain the ability to specifically bind to an antigen. These fragments are constituted of various arrangements of the variable region heavy chain (VH) and/or light chain (VL); and in some embodiments, include constant region heavy chain 1 (CHI) and light chain (CL). In some embodiments, they lack the Fc region constituted of heavy chain 2 (CH2) and 3 (CH3) domains. Embodiments of antigen binding fragments and the modifications thereof may include: (i) the Fab fragment type constituted with the VL, VH, CL, and CHI domains; (ii) the Fd fragment type constituted with the VH and CHI domains; (iii) the Fv fragment type constituted with the VH and VL domains; (iv) the single domain fragment type, dAb, (Ward, 1989; McCafferty et al., 1990; Holt et al., 2003) constituted with a single VH or VL domain; (v) isolated complementarity determining region (CDR) regions. Such terms are described, for example, in Harlow and Lane, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, NY (1989); Molec. Biology and Biotechnology: A Comprehensive Desk Reference (Myers, R. A. (ed.), New York: VCH Publisher, Inc.); Huston et al., Cell Biophysics, 22:189-224 (1993); Pluckthun and Skerra, Meth. Enzymok, 178:497-515 (1989) and in Day, E. D., Advanced Immunochemistry, 2d ed., Wiley-Liss, Inc. New York, N.Y. (1990); Antibodies, 4:259-277 (2015), each of which are incorporated by reference.

[0119] Antigen-binding fragments also include fragments of an antibody that retain exactly, at least, or at most 1, 2, or 3 complementarity determining regions (CDRs) from a light chain variable region. Fusions of CDR-containing sequences to an Fc region (or a CH2 or CH3 region thereof) are included within the scope of this definition including, for example, scFv fused, directly or indirectly, to an Fc region are included herein.

[0120] The term Fab fragment means a monovalent antigen-binding fragment of an antibody containing the VL, VH, CL and CHI domains. The term Fab' fragment means a monovalent antigen-binding fragment of a monoclonal antibody that is larger than a Fab fragment. For example, a Fab' fragment includes the VL, VH, CL and CHI domains and all or part of the hinge region. The term F(ab')2 fragment means a bivalent antigen-binding fragment of a monoclonal antibody comprising two Fab' fragments linked by a disulfide bridge at the hinge region. An F(ab')2 fragment includes, for example, all or part of the two VH and VL domains, and can further include all or part of the two CL and CHI domains.

[0121] The term Fd fragment means a fragment of the heavy chain of a monoclonal antibody, which includes all or part of the VH, including the CDRs. An Fd fragment can further include CHI region sequences.

[0122] The term Fv fragment means a monovalent antigen-binding fragment of a monoclonal antibody, including all or part of the VL and VH, and absent of the CL and CHI domains. The VL and VH include, for example, the CDRs. Single-chain antibodies (sFv or scFv) are Fv molecules in which the VL and VH regions have been connected by a flexible linker to form a single polypeptide chain, which forms an antigen-binding fragment. Single chain antibodies are discussed in detail in International Patent Application Publication No. WO 88/01649 and U.S. Pat. Nos. 4,946,778 and 5,260,203, the disclosures of which are herein incorporated by reference. The term (scFv)2 means bivalent or bispecific sFv polypeptide chains that include oligomerization domains at their C-termini, separated from the sFv by a hinge region (Pack et al. 1992). The oligomerization domain comprises self-associating a-helices, e.g., leucine zippers, which can be further stabilized by additional disulfide bonds. (scFv)2 fragments are also known as “miniantibodies” or “minibodies.”

[0123] single domain antibody is an antigen-binding fragment containing only a VH or the VL domain. In some instances, two or more VH regions are covalently joined with a peptide linker to create a bivalent domain antibody. The two VH regions of a bivalent domain antibody may target the same or different antigens.

2. Fragment Crystallizable Region, Fc

[0124] An Fc region contains two heavy chain fragments comprising the CH2 and CH3 domains of an antibody. The two heavy chain fragments are held together by two or more disulfide bonds and by hydrophobic interactions of the CH3 domains. The term “Fc polypeptide” as used herein includes native and mutein forms of polypeptides derived from the Fc region of an antibody. Truncated forms of such polypeptides containing the hinge region that promotes dimerization are included.

C. Polypeptides with antibody CDRs & Scaffolding Domains that Display the CDRs

[0125] Antigen-binding peptide scaffolds, such as complementarity-determining regions (CDRs), are used to generate protein-binding molecules in accordance with the embodiments. Generally, a person skilled in the art can determine the type of protein scaffold on which to graft at least one of the CDRs. It is known that scaffolds, optimally, must meet a number of criteria such as: good phylogenetic conservation; known three-dimensional structure; small size; few or no post-transcriptional modifications; and/or be easy to produce, express, and purify. Skerra, J Mol Recognit, 13:167-87 (2000).

[0126] The protein scaffolds can be sourced from, but not limited to: fibronectin type III FN3 domain (known as “monobodies”), fibronectin type III domain 10, lipocalin, anticalin, Z- domain of protein A of Staphylococcus aureus, thioredoxin A or proteins with a repeated motif such as the “ankyrin repeat”, the “armadillo repeat”, the “leucine-rich repeat” and the “tetratricopeptide repeat”. Such proteins are described in US Patent Publication Nos. 2010/0285564, 2006/0058510, 2006/0088908, 2005/0106660, and PCT Publication No. W02006/056464, each of which are specifically incorporated herein by reference in their entirety. Scaffolds derived from toxins from scorpions, insects, plants, mollusks, etc., and the protein inhibiters of neuronal NO synthase (PIN) may also be used.

D. Antibody Binding [0127] The term “selective binding agent” refers to a molecule that binds to an antigen. Non-limiting examples include antibodies, antigen-binding fragments, scFv, Fab, Fab', F(ab')2, single chain antibodies, peptides, peptide fragments and proteins.

[0128] The term “binding” refers to a direct association between two molecules, due to, for example, covalent, electrostatic, hydrophobic, and ionic and/or hydrogen-bond interactions, including interactions such as salt bridges and water bridges. “Immunologically reactive” means that the selective binding agent or antibody of interest will bind with antigens present in a biological sample. The term “immune complex” refers the combination formed when an antibody or selective binding agent binds to an epitope on an antigen.

1. Affinity/Avidity

[0129] The term “affinity” refers the strength with which an antibody or selective binding agent binds an epitope. In antibody binding reactions, this is expressed as the affinity constant (Ka or ka sometimes referred to as the association constant) for any given antibody or selective binding agent. Affinity is measured as a comparison of the binding strength of the antibody to its antigen relative to the binding strength of the antibody to an unrelated amino acid sequence. Affinity can be expressed as, for example, 20- fold greater binding ability of the antibody to its antigen then to an unrelated amino acid sequence. As used herein, the term “avidity” refers to the resistance of a complex of two or more agents to dissociation after dilution. The terms “immunoreactive” and “preferentially binds” are used interchangeably herein with respect to antibodies and/or selective binding agent.

[0130] There are several experimental methods that can be used by one skilled in the art to evaluate the binding affinity of any given antibody or selective binding agent for its antigen. This is generally done by measuring the equilibrium dissociation constant (KD or Kd), using the equation KD = koff / kon = [A][B]/[AB] The term koff is the rate of dissociation between the antibody and antigen per unit time, and is related to the concentration of antibody and antigen present in solution in the unbound form at equilibrium. The term kon is the rate of antibody and antigen association per unit time, and is related to the concentration of the bound antigen-antibody complex at equilibrium. The units used for measuring the KD are mol/L (molarity, or M), or concentration. The Ka of an antibody is the opposite of the KD, and is determined by the equation Ka = 1/KD. Examples of some experimental methods that can be used to determine the KD value are: enzyme-linked immunosorbent assays (ELISA), isothermal titration calorimetry (FTC), fluorescence anisotropy, surface plasmon resonance (SPR), and affinity capillary electrophoresis (ACE). The affinity constant (Ka) of an antibody is the opposite of the KD, and is determined by the equation Ka = 1/ KD.

[0131] Antibodies deemed useful in certain embodiments may have an affinity constant (Ka) of about, at least about, or at most about 10 ⁶ , 10 ⁷ , 10 ⁸ ,10 ⁹ , or 10 ¹⁰ M or any range derivable therein. Similarly, in some embodiments, antibodies may have a dissociation constant of about, at least about or at most about 10 ⁶ , 10 ⁷ , 10 ⁸ , 10 ⁹ , 10 ¹⁰ M, or any range derivable therein. These values are reported for antibodies discussed herein and the same assay may be used to evaluate the binding properties of such antibodies. An antibody of the invention is said to “specifically bind” its target antigen when the dissociation constant (KD) is £ 1 CT ⁸ M. The antibody specifically binds antigen with “high affinity” when the KD is £5 x 10 ^-9 M, and with “very high affinity” when the KD is £5 ^c KG ¹⁰ M.

2. Epitope Specificity

[0132] The epitope of an antigen is the specific region of the antigen for which an antibody has binding affinity. In the case of protein or polypeptide antigens, the epitope is the specific residues (or specified amino acids or protein segment) that the antibody binds with high affinity. An antibody does not necessarily contact every residue within the protein. Nor does every single amino acid substitution or deletion within a protein necessarily affect binding affinity. For purposes of this specification and the accompanying claims, the terms “epitope” and “antigenic determinant” are used interchangeably to refer to the site on an antigen to which B and/or T cells respond or recognize. Polypeptide epitopes can be formed from both contiguous amino acids and noncontiguous amino acids juxtaposed by tertiary folding of a polypeptide. An epitope typically includes at least 3, and typically 5-10 amino acids in a unique spatial conformation.

[0133] Epitope specificity of an antibody can be determined in a variety of ways. One approach, for example, involves testing a collection of overlapping peptides of about 15 amino acids spanning the full sequence of the protein and differing in increments of a small number of amino acids (e.g., 3 to 30 amino acids). The peptides are immobilized in separate wells of a microtiter dish. Immobilization can be accomplished, for example, by biotinylating one terminus of the peptides. This process may affect the antibody affinity for the epitope, therefore different samples of the same peptide can be biotinylated at the N and C terminus and immobilized in separate wells for the purposes of comparison. This is useful for identifying end-specific antibodies. Optionally, additional peptides can be included terminating at a particular amino acid of interest. This approach is useful for identifying end-specific antibodies to internal fragments. An antibody or antigen-binding fragment is screened for binding to each of the various peptides. The epitope is defined as a segment of amino acids that is common to all peptides to which the antibody shows high affinity binding.

3. Modification of Antibody Antigen-Binding Domains

[0134] It is understood that the antibodies of the present invention may be modified, such that they are substantially identical to the antibody polypeptide sequences, or fragments thereof, and still bind the epitopes of the present invention. Polypeptide sequences are “substantially identical” when optimally aligned using such programs as Clustal Omega, IGBLAST, GAP or BESTFIT using default gap weights, they share at least 80% sequence identity, at least 90% sequence identity, at least 95% sequence identity, at least 96% sequence identity, at least 97% sequence identity, at least 98% sequence identity, or at least 99% sequence identity or any range therein.

[0135] As discussed herein, minor variations in the amino acid sequences of antibodies or antigen-binding regions thereof are contemplated as being encompassed by the present invention, providing that the variations in the amino acid sequence maintain at least 75%, more preferably at least 80%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% and most preferably at least 99% sequence identity. In particular, conservative amino acid replacements are contemplated.

[0136] Conservative replacements are those that take place within a family of amino acids that are related in their side chains. Genetically encoded amino acids are generally divided into families based on the chemical nature of the side chain; e.g., acidic (aspartate, glutamate), basic (lysine, arginine, histidine), nonpolar (alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), and uncharged polar (glycine, asparagine, glutamine, cysteine, serine, threonine, tyrosine). For example, it is reasonable to expect that an isolated replacement of a leucine moiety with an isoleucine or valine moiety, or a similar replacement of an amino acid with a structurally related amino acid in the same family, will not have a major effect on the binding or properties of the resulting molecule, especially if the replacement does not involve an amino acid within a framework site. Whether an amino acid change results in a functional peptide can readily be determined by assaying the specific activity of the polypeptide derivative. Standard ELISA, Surface Plasmon Resonance (SPR), or other antibody binding assays can be performed by one skilled in the art to make a quantitative comparison of antigen binging affinity between the unmodified antibody and any polypeptide derivatives with conservative substitutions generated through any of several methods available to one skilled in the art.

[0137] Fragments or analogs of antibodies or immunoglobulin molecules can be readily prepared by those skilled in the art. Preferred amino- and carboxy -termini of fragments or analogs occur near boundaries of functional domains. Structural and functional domains can be identified by comparison of the nucleotide and/or amino acid sequence data to public or proprietary sequence databases. Preferably, computerized comparison methods are used to identify sequence motifs or predicted protein conformation domains that occur in other proteins of known structure and/or function. Standard methods to identify protein sequences that fold into a known three-dimensional structure are available to those skilled in the art; Dill and McCallum., Science 338:1042-1046 (2012). Several algorithms for predicting protein structures and the gene sequences that encode these have been developed, and many of these algorithms can be found at the National Center for Biotechnology Information (on the World Wide Web at ncbi.nlm.nih.gov/guide/proteins/) and at the Bioinformatics Resource Portal (on the World Wide Web at expasy.org/proteomics). Thus, the foregoing examples demonstrate that those of skill in the art can recognize sequence motifs and structural conformations that may be used to define structural and functional domains in accordance with the invention. [0138] Framework modifications can be made to antibodies to decrease immunogenicity, for example, by “backmutating” one or more framework residues to a corresponding germline sequence.

[0139] It is also contemplated that the antigen-binding domain may be multi-specific or multivalent by multimerizing the antigen-binding domain with VH and VL region pairs that bind either the same antigen (multi -valent) or a different antigen (multi-specific).

V. Proteinaceous Compositions

[0140] As used herein, a “protein” “peptide” or “polypeptide” refers to a molecule comprising at least five amino acid residues. As used herein, the term “wild-type” refers to the endogenous version of a molecule that occurs naturally in an organism. In some embodiments, wild-type versions of a protein or polypeptide are employed, however, in many embodiments of the disclosure, a modified protein or polypeptide is employed to generate an immune response. The terms described above may be used interchangeably. A “modified protein” or “modified polypeptide” or a “variant” refers to a protein or polypeptide whose chemical structure, particularly its amino acid sequence, is altered with respect to the wild-type protein or polypeptide. In some embodiments, a modified/variant protein or polypeptide has at least one modified activity or function (recognizing that proteins or polypeptides may have multiple activities or functions). It is specifically contemplated that a modified/variant protein or polypeptide may be altered with respect to one activity or function yet retain a wild-type activity or function in other respects, such as immunogenicity.

[0141] Where a protein is specifically mentioned herein, it is in general a reference to a native (wild-type) or recombinant (modified) protein or, optionally, a protein in which any signal sequence has been removed. The protein may be isolated directly from the organism of which it is native, produced by recombinant DNA/exogenous expression methods, or produced by solid-phase peptide synthesis (SPPS) or other in vitro methods. In particular embodiments, there are isolated nucleic acid segments and recombinant vectors incorporating nucleic acid sequences that encode a polypeptide (e.g., an antibody or fragment thereof). The term “recombinant” may be used in conjunction with a polypeptide or the name of a specific polypeptide, and this generally refers to a polypeptide produced from a nucleic acid molecule that has been manipulated in vitro or that is a replication product of such a molecule.

[0142] In certain embodiments the size of a protein or polypeptide (wild-type or modified) may comprise, but is not limited to, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,

22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 525, 550, 575, 600, 625, 650, 675, 700, 725, 750, 775, 800, 825, 850, 875, 900, 925, 950, 975, 1000, 1100, 1200, 1300, 1400, 1500, 1750, 2000,

2250, 2500 amino acid residues or greater, and any range derivable therein, or derivative of a corresponding amino sequence described or referenced herein. It is contemplated that polypeptides may be mutated by truncation, rendering them shorter than their corresponding wild-type form, also, they might be altered by fusing or conjugating a heterologous protein or polypeptide sequence with a particular function (e.g., for targeting or localization, for enhanced immunogenicity, for purification purposes, etc.).

[0143] The polypeptides, proteins, or polynucleotides encoding such polypeptides or proteins of the disclosure may include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,

21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45,

46, 47, 48, 49, or 50 (or any derivable range therein) or more variant amino acids or nucleic acid substitutions or be at least 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% (or any derivable range therein) similar, identical, or homologous with, with at least, or with at most 3,

4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,

31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55,

56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,

81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104,

105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123,

124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142,

143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161,

162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180,

181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199,

200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218,

219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237,

238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 300, 400, 500, 550, 1000 or more contiguous amino acids or nucleic acids, or any range derivable therein, of SEQ ID Nos: 1- 1403. In specific embodiments, the peptide or polypeptide is or is based on a human sequence. In certain embodiments, the peptide or polypeptide is not naturally occurring and/or is in a combination of peptides or polypeptides.

[0144] In some embodiments, a peptide or polypeptide described herein comprises, comprises at least, or comprises at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 substitutions (or any derivable range therein) at amino acid position 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31,

32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56,

57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,

82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104,

105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, or 130 (or any range derivable therein) of SEQ ID NOS: 1-1403. In some embodiments, the amino acid at position 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,

16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40,

41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65,

66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90,

91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, or 130 of a peptide or polypeptide of SEQ ID NO: 1-1403 is substituted with an alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, or valine.

[0145] In some embodiments, the protein or polypeptide may comprise amino acids 1 to 2,

3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29,

30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54,

55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79

80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, S '3, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578,

579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597,

598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616,

617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635,

636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654,

655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 673,

674, 675, 676, 677, 678, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689, 690, 691, 692,

693, 694, 695, 696, 697, 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, 708, 709, 710, 711,

712, 713, 714, 715, 716, 717, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 728, 729, 730,

731, 732, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742, 743, 744, 745, 746, 747, 748, 749,

750, 751, 752, 753, 754, 755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766, 767, 768,

769, 770, 771, 772, 773, 774, 775, 776, 777, 778, 779, 780, 781, 782, 783, 784, 785, 786, 787,

788, 789, 790, 791, 792, 793, 794, 795, 796, 797, 798, 799, 800, 801, 802, 803, 804, 805, 806,

807, 808, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825,

826, 827, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, 841, 842, 843, 844,

845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855, 856, 857, 858, 859, 860, 861, 862, 863,

864, 865, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 880, 881, 882,

883, 884, 885, 886, 887, 888, 889, 890, 891, 892, 893, 894, 895, 896, 897, 898, 899, 900, 901,

902, 903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920,

921, 922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939,

940, 941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958,

959, 960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977,

978, 979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 993, 994, 995, 996,

997, 998, 999, or 1000, (or any derivable range therein) of SEQ ID NOs: 1-1403.

[0146] In some embodiments, the protein, polypeptide, or nucleic acid may comprise 1, 2, 3,

4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,

31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55,

56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,

81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123,

124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142,

143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161,

162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180,

181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, , 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218,, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237,, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256,, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275,, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294,, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313,, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332,, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351,, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370,, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389,, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408,, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427,, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446,, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465,, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483, 484,, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502, 503,, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522,, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541,, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560,, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579,, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598,, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617,, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635, 636,, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654, 655,, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 673, 674,, 676, 677, 678, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689, 690, 691, 692, 693,, 695, 696, 697, 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, 708, 709, 710, 711, 712,, 714, 715, 716, 717, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 728, 729, 730, 731,, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742, 743, 744, 745, 746, 747, 748, 749, 750,, 752, 753, 754, 755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766, 767, 768, 769,, 771, 772, 773, 774, 775, 776, 777, 778, 779, 780, 781, 782, 783, 784, 785, 786, 787, 788,, 790, 791, 792, 793, 794, 795, 796, 797, 798, 799, 800, 801, 802, 803, 804, 805, 806, 807,, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825, 826,, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, 841, 842, 843, 844, 845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855, 856, 857, 858, 859, 860, 861, 862, 863, 864,

865, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 880, 881, 882, 883,

884, 885, 886, 887, 888, 889, 890, 891, 892, 893, 894, 895, 896, 897, 898, 899, 900, 901, 902,

903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920, 921,

922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939, 940,

941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958, 959,

960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977, 978,

979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 993, 994, 995, 996, 997,

998, 999, or 1000, (or any derivable range therein) contiguous amino acids of SEQ ID NOs:l- 1403.

[0147] In some embodiments, the polypeptide, protein, or nucleic acid may comprise, comprise at least, comprises at most, or comprise about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13,

14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,

39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63,

64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88,

89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129,

130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148,

149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167,

168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186,

187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205,

206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224,

225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243,

244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262,

263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281,

282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300,

301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319,

320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338,

339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357,

358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376,

377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395,

396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414,

415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433,

434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 673, 674, 675, 676, 677, 678, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689, 690, 691, 692, 693, 694, 695, 696, 697, 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, 708, 709, 710, 711, 712, 713, 714, 715, 716, 717, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 728, 729, 730, 731, 732, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742, 743, 744, 745, 746, 747, 748, 749, 750, 751, 752, 753, 754, 755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766, 767, 768, 769, 770, 771, 772, 773, 774, 775, 776, 777, 778, 779, 780, 781, 782, 783, 784, 785, 786, 787, 788, 789, 790, 791, 792, 793, 794, 795, 796, 797, 798, 799, 800, 801, 802, 803, 804, 805, 806, 807, 808, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825, 826, 827, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, 841, 842, 843, 844, 845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855, 856, 857, 858, 859, 860, 861, 862, 863, 864, 865, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 880, 881, 882, 883, 884, 885, 886, 887, 888, 889, 890, 891, 892, 893, 894, 895, 896, 897, 898, 899, 900, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920, 921, 922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939, 940, 941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958, 959, 960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977, 978, 979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 99: 5, 994, 995, 996, 997, 998, 999, or 1000 (or any derivable range therein) contiguous amino acids of SEQ ID Nos: 1-1403 that are, are at least, are at most, are exactly, or are about 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%,

70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%,

86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% (or any derivable range therein) similar, identical, or homologous with one of SEQ ID NOS:l- 1403.

[0148] In some aspects there is a nucleic acid molecule or polypeptide starting at position 1,

2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79,

80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, S '3, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122,

123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141,

142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160,

161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179,

180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198,

199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217,

218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236,

237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255,

256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274,

275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293,

294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312,

313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331,

332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350,

351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369,

370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388,

389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407,

408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426,

427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445,

446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464,

465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483,

484, 485, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502,

503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521,

522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540,

541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559,

560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578,

579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597,

598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635,

636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654,

655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 673,

674, 675, 676, 677, 678, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689, 690, 691, 692,

693, 694, 695, 696, 697, 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, 708, 709, 710, 711,

712, 713, 714, 715, 716, 717, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 728, 729, 730,

731, 732, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742, 743, 744, 745, 746, 747, 748, 749,

750, 751, 752, 753, 754, 755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766, 767, 768,

769, 770, 771, 772, 773, 774, 775, 776, 777, 778, 779, 780, 781, 782, 783, 784, 785, 786, 787,

788, 789, 790, 791, 792, 793, 794, 795, 796, 797, 798, 799, 800, 801, 802, 803, 804, 805, 806,

807, 808, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825,

826, 827, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, 841, 842, 843, 844,

845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855, 856, 857, 858, 859, 860, 861, 862, 863,

864, 865, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 880, 881, 882,

883, 884, 885, 886, 887, 888, 889, 890, 891, 892, 893, 894, 895, 896, 897, 898, 899, 900, 901,

902, 903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920,

921, 922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939,

940, 941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958,

959, 960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977,

978, 979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 993, 994, 995, 996,

997, 998, 999, or 1000 of any of SEQ ID NOS: 1-1403 and comprising, comprising at least, comprising at most, or comprising about 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,

19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43,

44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68,

69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93,

94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132,

133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151,

152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170,

171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189,

190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208,

209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227,

228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246,

247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, , 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303,, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322,, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341,, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360,, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379,, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398,, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417,, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436,, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455,, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474,, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492, 493,, 495, 496, 497, 498, 499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512,, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531,, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550,, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569,, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588,, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607,, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626,, 628, 629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645,, 647, 648, 649, 650, 651, 652, 653, 654, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664,, 666, 667, 668, 669, 670, 671, 672, 673, 674, 675, 676, 677, 678, 679, 680, 681, 682, 683,, 685, 686, 687, 688, 689, 690, 691, 692, 693, 694, 695, 696, 697, 698, 699, 700, 701, 702,, 704, 705, 706, 707, 708, 709, 710, 711, 712, 713, 714, 715, 716, 717, 718, 719, 720, 721,, 723, 724, 725, 726, 727, 728, 729, 730, 731, 732, 733, 734, 735, 736, 737, 738, 739, 740,, 742, 743, 744, 745, 746, 747, 748, 749, 750, 751, 752, 753, 754, 755, 756, 757, 758, 759,, 761, 762, 763, 764, 765, 766, 767, 768, 769, 770, 771, 772, 773, 774, 775, 776, 777, 778,, 780, 781, 782, 783, 784, 785, 786, 787, 788, 789, 790, 791, 792, 793, 794, 795, 796, 797,, 799, 800, 801, 802, 803, 804, 805, 806, 807, 808, 809, 810, 811, 812, 813, 814, 815, 816,, 818, 819, 820, 821, 822, 823, 824, 825, 826, 827, 828, 829, 830, 831, 832, 833, 834, 835,, 837, 838, 839, 840, 841, 842, 843, 844, 845, 846, 847, 848, 849, 850, 851, 852, 853, 854,, 856, 857, 858, 859, 860, 861, 862, 863, 864, 865, 866, 867, 868, 869, 870, 871, 872, 873,, 875, 876, 877, 878, 879, 880, 881, 882, 883, 884, 885, 886, 887, 888, 889, 890, 891, 892,, 894, 895, 896, 897, 898, 899, 900, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920, 921, 922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939, 940, 941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958, 959, 960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977, 978, 979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 993, 994, 995, 996, 997, 998, 999, or 1000 (or any derivable range therein) contiguous amino acids or nucleotides of any of SEQ ID NOS: 1-1403.

[0149] The nucleotide as well as the protein, polypeptide, and peptide sequences for various genes have been previously disclosed, and may be found in the recognized computerized databases. Two commonly used databases are the National Center for Biotechnology Information’s Genbank and GenPept databases (on the World Wide Web at ncbi.nlm.nih.gov/) and The Universal Protein Resource (UniProt; on the World Wide Web at uniprot.org). The coding regions for these genes may be amplified and/or expressed using the techniques disclosed herein or as would be known to those of ordinary skill in the art.

[0150] It is contemplated that in compositions of the disclosure, there is between about 0.001 mg and about 10 mg of total polypeptide, peptide, and/or protein per ml. The concentration of protein in a composition can be about, at least about or at most about 0.001, 0.010, 0.050, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0 mg/ml or more (or any range derivable therein).

[0151] The following is a discussion of changing the amino acid subunits of a protein to create an equivalent, or even improved, second-generation variant polypeptide or peptide. For example, certain amino acids may be substituted for other amino acids in a protein or polypeptide sequence with or without appreciable loss of interactive binding capacity with structures such as, for example, antigen-binding regions of antibodies or binding sites on substrate molecules. Since it is the interactive capacity and nature of a protein that defines that protein’s functional activity, certain amino acid substitutions can be made in a protein sequence and in its corresponding DNA coding sequence, and nevertheless produce a protein with similar or desirable properties. It is thus contemplated by the inventors that various changes may be made in the DNA sequences of genes which encode proteins without appreciable loss of their biological utility or activity.

[0152] The term “functionally equivalent codon” is used herein to refer to codons that encode the same amino acid, such as the six different codons for arginine. Also considered are “neutral substitutions” or “neutral mutations” which refers to a change in the codon or codons that encode biologically equivalent amino acids. [0153] Amino acid sequence variants of the disclosure can be substitutional, insertional, or deletion variants. A variation in a polypeptide of the disclosure may affect 1, 2, 3, 4, 5, 6, 7, 8,

9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33,

34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, or more non-contiguous or contiguous amino acids of the protein or polypeptide, as compared to wild-type. A variant can comprise an amino acid sequence that is at least 50%, 60%, 70%, 80%, or 90%, including all values and ranges there between, identical to any sequence provided or referenced herein. A variant can include 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or more substitute amino acids.

[0154] It also will be understood that amino acid and nucleic acid sequences may include additional residues, such as additional N- or C-terminal amino acids, or 5' or 3' sequences, respectively, and yet still be essentially identical as set forth in one of the sequences disclosed herein, so long as the sequence meets the criteria set forth above, including the maintenance of biological protein activity where protein expression is concerned. The addition of terminal sequences particularly applies to nucleic acid sequences that may, for example, include various non-coding sequences flanking either of the 5' or 3' portions of the coding region.

[0155] Deletion variants typically lack one or more residues of the native or wild type protein. Individual residues can be deleted or a number of contiguous amino acids can be deleted. A stop codon may be introduced (by substitution or insertion) into an encoding nucleic acid sequence to generate a truncated protein.

[0156] Insertional mutants typically involve the addition of amino acid residues at a non terminal point in the polypeptide. This may include the insertion of one or more amino acid residues. Terminal additions may also be generated and can include fusion proteins which are multimers or concatemers of one or more peptides or polypeptides described or referenced herein.

[0157] Substitutional variants typically contain the exchange of one amino acid for another at one or more sites within the protein or polypeptide, and may be designed to modulate one or more properties of the polypeptide, with or without the loss of other functions or properties. Substitutions may be conservative, that is, one amino acid is replaced with one of similar chemical properties. “Conservative amino acid substitutions” may involve exchange of a member of one amino acid class with another member of the same class. Conservative substitutions are well known in the art and include, for example, the changes of: alanine to serine; arginine to lysine; asparagine to glutamine or histidine; aspartate to glutamate; cysteine to serine; glutamine to asparagine; glutamate to aspartate; glycine to proline; histidine to asparagine or glutamine; isoleucine to leucine or valine; leucine to valine or isoleucine; lysine to arginine; methionine to leucine or isoleucine; phenylalanine to tyrosine, leucine or methionine; serine to threonine; threonine to serine; tryptophan to tyrosine; tyrosine to tryptophan or phenylalanine; and valine to isoleucine or leucine. Conservative amino acid substitutions may encompass non-naturally occurring amino acid residues, which are typically incorporated by chemical peptide synthesis rather than by synthesis in biological systems. These include peptidomimetics or other reversed or inverted forms of amino acid moieties. [0158] Alternatively, substitutions may be “non-conservative”, such that a function or activity of the polypeptide is affected. Non-conservative changes typically involve substituting an amino acid residue with one that is chemically dissimilar, such as a polar or charged amino acid for a nonpolar or uncharged amino acid, and vice versa. Non-conservative substitutions may involve the exchange of a member of one of the amino acid classes for a member from another class.

[0159] One skilled in the art can determine suitable variants of polypeptides as set forth herein using well-known techniques. One skilled in the art may identify suitable areas of the molecule that may be changed without destroying activity by targeting regions not believed to be important for activity. The skilled artisan will also be able to identify amino acid residues and portions of the molecules that are conserved among similar proteins or polypeptides. In further embodiments, areas that may be important for biological activity or for structure may be subject to conservative amino acid substitutions without significantly altering the biological activity or without adversely affecting the protein or polypeptide structure.

[0160] In making such changes, the hydropathy index of amino acids may be considered. The hydropathy profile of a protein is calculated by assigning each amino acid a numerical value (“hydropathy index”) and then repetitively averaging these values along the peptide chain. Each amino acid has been assigned a value based on its hydrophobicity and charge characteristics. They are: isoleucine (+4.5); valine (+4.2); leucine (+3.8); phenylalanine (+2.8); cysteine/cysteine (+2.5); methionine (+1.9); alanine (+1.8); glycine (-0.4); threonine (-0.7); serine (-0.8); tryptophan (-0.9); tyrosine (-1.3); proline (1.6); histidine (-3.2); glutamate (-3.5); glutamine (-3.5); aspartate (-3.5); asparagine (-3.5); lysine (-3.9); and arginine (-4.5). The importance of the hydropathy amino acid index in conferring interactive biologic function on a protein is generally understood in the art (Kyte et ah, J. Mol. Biol. 157:105-131 (1982)). It is accepted that the relative hydropathic character of the amino acid contributes to the secondary structure of the resultant protein or polypeptide, which in turn defines the interaction of the protein or polypeptide with other molecules, for example, enzymes, substrates, receptors, DNA, antibodies, antigens, and others. It is also known that certain amino acids may be substituted for other amino acids having a similar hydropathy index or score, and still retain a similar biological activity. In making changes based upon the hydropathy index, in certain embodiments, the substitution of amino acids whose hydropathy indices are within ±2 is included. In some aspects of the invention, those that are within ±1 are included, and in other aspects of the invention, those within ±0.5 are included.

[0161] It also is understood in the art that the substitution of like amino acids can be effectively made based on hydrophilicity. U.S. Patent 4,554,101, incorporated herein by reference, states that the greatest local average hydrophilicity of a protein, as governed by the hydrophilicity of its adjacent amino acids, correlates with a biological property of the protein. In certain embodiments, the greatest local average hydrophilicity of a protein, as governed by the hydrophilicity of its adjacent amino acids, correlates with its immunogenicity and antigen binding, that is, as a biological property of the protein. The following hydrophilicity values have been assigned to these amino acid residues: arginine (+3.0); lysine (+3.0); aspartate (+3.0+1); glutamate (+3.0+1); serine (+0.3); asparagine (+0.2); glutamine (+0.2); glycine (0); threonine (-0.4); proline (-0.5+1); alanine (-0.5); histidine (-0.5); cysteine (-1.0); methionine (-1.3); valine (-1.5); leucine (-1.8); isoleucine (-1.8); tyrosine (-2.3); phenylalanine (-2.5); and tryptophan (-3.4). In making changes based upon similar hydrophilicity values, in certain embodiments, the substitution of amino acids whose hydrophilicity values are within ±2 are included, in other embodiments, those which are within ±1 are included, and in still other embodiments, those within ±0.5 are included. In some instances, one may also identify epitopes from primary amino acid sequences based on hydrophilicity. These regions are also referred to as “epitopic core regions.” It is understood that an amino acid can be substituted for another having a similar hydrophilicity value and still produce a biologically equivalent and immunologically equivalent protein.

[0162] Additionally, one skilled in the art can review structure-function studies identifying residues in similar polypeptides or proteins that are important for activity or structure. In view of such a comparison, one can predict the importance of amino acid residues in a protein that correspond to amino acid residues important for activity or structure in similar proteins. One skilled in the art may opt for chemically similar amino acid substitutions for such predicted important amino acid residues.

[0163] One skilled in the art can also analyze the three-dimensional structure and amino acid sequence in relation to that structure in similar proteins or polypeptides. In view of such information, one skilled in the art may predict the alignment of amino acid residues of an antibody with respect to its three-dimensional structure. One skilled in the art may choose not to make changes to amino acid residues predicted to be on the surface of the protein, since such residues may be involved in important interactions with other molecules. Moreover, one skilled in the art may generate test variants containing a single amino acid substitution at each desired amino acid residue. These variants can then be screened using standard assays for binding and/or activity, thus yielding information gathered from such routine experiments, which may allow one skilled in the art to determine the amino acid positions where further substitutions should be avoided either alone or in combination with other mutations. Various tools available to determine secondary structure can be found on the world wide web at expasy.org/proteomics/protein_structure.

[0164] In some embodiments of the invention, amino acid substitutions are made that: (1) reduce susceptibility to proteolysis, (2) reduce susceptibility to oxidation, (3) alter binding affinity for forming protein complexes, (4) alter ligand or antigen binding affinities, and/or (5) confer or modify other physicochemical or functional properties on such polypeptides. For example, single or multiple amino acid substitutions (in certain embodiments, conservative amino acid substitutions) may be made in the naturally occurring sequence. Substitutions can be made in that portion of the antibody that lies outside the domain(s) forming intermolecular contacts. In such embodiments, conservative amino acid substitutions can be used that do not substantially change the structural characteristics of the protein or polypeptide (e.g., one or more replacement amino acids that do not disrupt the secondary structure that characterizes the native antibody).

VI. Nucleic Acids

[0165] In certain embodiments, nucleic acid sequences can exist in a variety of instances such as: isolated segments and recombinant vectors of incorporated sequences or recombinant polynucleotides encoding one or both chains of an antibody, or a fragment, derivative, mutein, or variant thereof, polynucleotides sufficient for use as hybridization probes, PCR primers or sequencing primers for identifying, analyzing, mutating or amplifying a polynucleotide encoding a polypeptide, anti-sense nucleic acids for inhibiting expression of a polynucleotide, and complementary sequences of the foregoing described herein. Nucleic acids that encode the epitope to which certain of the antibodies provided herein are also provided. Nucleic acids encoding fusion proteins that include these peptides are also provided. The nucleic acids can be single-stranded or double-stranded and can comprise RNA and/or DNA nucleotides and artificial variants thereof (e.g., peptide nucleic acids).

[0166] The term “polynucleotide” refers to a nucleic acid molecule that either is recombinant or has been isolated from total genomic nucleic acid. Included within the term “polynucleotide” are oligonucleotides (nucleic acids 100 residues or less in length), recombinant vectors, including, for example, plasmids, cosmids, phage, viruses, and the like. Polynucleotides include, in certain aspects, regulatory sequences, isolated substantially away from their naturally occurring genes or protein encoding sequences. Polynucleotides may be single- stranded (coding or antisense) or double- stranded, and may be RNA, DNA (genomic, cDNA or synthetic), analogs thereof, or a combination thereof. Additional coding or non-coding sequences may, but need not, be present within a polynucleotide.

[0167] In this respect, the term “gene,” “polynucleotide,” or “nucleic acid” is used to refer to a nucleic acid that encodes a protein, polypeptide, or peptide (including any sequences required for proper transcription, post-translational modification, or localization). As will be understood by those in the art, this term encompasses genomic sequences, expression cassettes, cDNA sequences, and smaller engineered nucleic acid segments that express, or may be adapted to express, proteins, polypeptides, domains, peptides, fusion proteins, and mutants. A nucleic acid encoding all or part of a polypeptide may contain a contiguous nucleic acid sequence encoding all or a portion of such a polypeptide. It also is contemplated that a particular polypeptide may be encoded by nucleic acids containing variations having slightly different nucleic acid sequences but, nonetheless, encode the same or substantially similar protein.

[0168] In certain embodiments, there are polynucleotide variants having substantial sequence identity to the sequences disclosed herein; those comprising at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% or higher sequence identity, including all values and ranges there between, compared to a polynucleotide sequence provided herein using the methods described herein (e.g., BLAST analysis using standard parameters). In certain aspects, the isolated polynucleotide will comprise a nucleotide sequence encoding a polypeptide that has at least 90%, preferably 95% and above, identity to an amino acid sequence described herein, over the entire length of the sequence; or a nucleotide sequence complementary to said isolated polynucleotide.

[0169] The nucleic acid segments, regardless of the length of the coding sequence itself, may be combined with other nucleic acid sequences, such as promoters, polyadenylation signals, additional restriction enzyme sites, multiple cloning sites, other coding segments, and the like, such that their overall length may vary considerably. The nucleic acids can be any length. They can be, for example, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 75, 100, 125, 175, 200, 250, 300, 350, 400, 450, 500, 750, 1000, 1500, 3000, 5000 or more nucleotides in length, and/or can comprise one or more additional sequences, for example, regulatory sequences, and/or be a part of a larger nucleic acid, for example, a vector. It is therefore contemplated that a nucleic acid fragment of almost any length may be employed, with the total length preferably being limited by the ease of preparation and use in the intended recombinant nucleic acid protocol. In some cases, a nucleic acid sequence may encode a polypeptide sequence with additional heterologous coding sequences, for example to allow for purification of the polypeptide, transport, secretion, post-translational modification, or for therapeutic benefits such as targeting or efficacy. As discussed above, a tag or other heterologous polypeptide may be added to the modified polypeptide-encoding sequence, wherein “heterologous” refers to a polypeptide that is not the same as the modified polypeptide.

1. Hybridization

[0170] The nucleic acids that hybridize to other nucleic acids under particular hybridization conditions. Methods for hybridizing nucleic acids are well known in the art. See, e.g., Current Protocols in Molecular Biology, John Wiley and Sons, N.Y. (1989), 6.3.1-6.3.6. As defined herein, a moderately stringent hybridization condition uses a prewashing solution containing 5x sodium chloride/sodium citrate (SSC), 0.5% SDS, 1.0 mM EDTA (pH 8.0), hybridization buffer of about 50% formamide, 6 SSC, and a hybridization temperature of 55° C. (or other similar hybridization solutions, such as one containing about 50% formamide, with a hybridization temperature of 42° C), and washing conditions of 60° C. in 0.5 x SSC, 0.1% SDS. A stringent hybridization condition hybridizes in 6xSSC at 45° C., followed by one or more washes in 0.1 xSSC, 0.2% SDS at 68° C. Furthermore, one of skill in the art can manipulate the hybridization and/or washing conditions to increase or decrease the stringency of hybridization such that nucleic acids comprising nucleotide sequence that are at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identical to each other typically remain hybridized to each other. [0171] The parameters affecting the choice of hybridization conditions and guidance for devising suitable conditions are set forth by, for example, Sambrook, Fritsch, and Maniatis (Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., chapters 9 and 11 (1989); Current Protocols in Molecular Biology, Ausubel et ak, eds., John Wiley and Sons, Inc., sections 2.10 and 6.3-6.4 (1995), both of which are herein incorporated by reference in their entirety for all purposes) and can be readily determined by those having ordinary skill in the art based on, for example, the length and/or base composition of the DNA.

1. Mutation

[0172] Changes can be introduced by mutation into a nucleic acid, thereby leading to changes in the amino acid sequence of a polypeptide (e.g., an antibody or antibody derivative) that it encodes. Mutations can be introduced using any technique known in the art. In one embodiment, one or more particular amino acid residues are changed using, for example, a site- directed mutagenesis protocol. In another embodiment, one or more randomly selected residues are changed using, for example, a random mutagenesis protocol. However it is made, a mutant polypeptide can be expressed and screened for a desired property.

[0173] Mutations can be introduced into a nucleic acid without significantly altering the biological activity of a polypeptide that it encodes. For example, one can make nucleotide substitutions leading to amino acid substitutions at non-essential amino acid residues. Alternatively, one or more mutations can be introduced into a nucleic acid that selectively changes the biological activity of a polypeptide that it encodes. See, eg., Romain Sluder et ah, Biochem. J. 449:581-594 (2013). For example, the mutation can quantitatively or qualitatively change the biological activity. Examples of quantitative changes include increasing, reducing or eliminating the activity. Examples of qualitative changes include altering the antigen specificity of an antibody.

2. Probes

[0174] In another aspect, nucleic acid molecules are suitable for use as primers or hybridization probes for the detection of nucleic acid sequences. A nucleic acid molecule can comprise only a portion of a nucleic acid sequence encoding a full-length polypeptide, for example, a fragment that can be used as a probe or primer or a fragment encoding an active portion of a given polypeptide.

[0175] In another embodiment, the nucleic acid molecules may be used as probes or PCR primers for specific antibody sequences. For instance, a nucleic acid molecule probe may be used in diagnostic methods or a nucleic acid molecule PCR primer may be used to amplify regions of DNA that could be used, inter alia, to isolate nucleic acid sequences for use in producing variable domains of antibodies. See, eg., Gaily Kivi et ak, BMC Biotechnol. 16:2 (2016). In a preferred embodiment, the nucleic acid molecules are oligonucleotides. In a more preferred embodiment, the oligonucleotides are from highly variable regions of the heavy and light chains of the antibody of interest. In an even more preferred embodiment, the oligonucleotides encode all or part of one or more of the CDRs.

[0176] Probes based on the desired sequence of a nucleic acid can be used to detect the nucleic acid or similar nucleic acids, for example, transcripts encoding a polypeptide of interest. The probe can comprise a label group, e.g., a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used to identify a cell that expresses the polypeptide.

VII. Antibody Production

A. Antibody Production

[0177] Methods for preparing and characterizing antibodies for use in diagnostic and detection assays, for purification, and for use as therapeutics are well known in the art as disclosed in, for example, U.S. Pat. Nos. 4,011,308; 4,722,890; 4,016,043; 3,876,504; 3,770,380; and 4,372,745 (see, e.g., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, 1988; incorporated herein by reference). These antibodies may be polyclonal or monoclonal antibody preparations, monospecific antisera, human antibodies, hybrid or chimeric antibodies, such as humanized antibodies, altered antibodies, F(ab')2 fragments, Fab fragments, Fv fragments, single-domain antibodies, dimeric or trimeric antibody fragment constructs, minibodies, or functional fragments thereof which bind to the antigen in question. In certain aspects, polypeptides, peptides, and proteins and immunogenic fragments thereof for use in various embodiments can also be synthesized in solution or on a solid support in accordance with conventional techniques. See, for example, Stewart and Young, (1984); Tarn et al, (1983); Merrifield, (1986); and Barany and Merrifield (1979), each incorporated herein by reference.

[0178] Briefly, a polyclonal antibody is prepared by immunizing an animal with an antigen or a portion thereof and collecting antisera from that immunized animal. The antigen may be altered compared to an antigen sequence found in nature. In some embodiments, a variant or altered antigenic peptide or polypeptide is employed to generate antibodies. Inocula are typically prepared by dispersing the antigenic composition in a physiologically tolerable diluent to form an aqueous composition. Antisera is subsequently collected by methods known in the arts, and the serum may be used as-is for various applications or else the desired antibody fraction may be purified by well-known methods, such as affinity chromatography (Harlow and Lane, Antibodies: A Laboratory Manual 1988).

[0179] Methods of making monoclonal antibodies are also well known in the art (Kohler and Milstein, 1975; Harlow and Lane, 1988, U.S. Patent 4,196,265, herein incorporated by reference in its entirety for all purposes). Typically, this technique involves immunizing a suitable animal with a selected immunogenic composition, e.g., a purified or partially purified protein, polypeptide, peptide or domain. Resulting antibody-producing B-cells from the immunized animal, or all dissociated splenocytes, are then induced to fuse with cells from an immortalized cell line to form hybridomas. Myeloma cell lines suited for use in hybridoma- producing fusion procedures preferably are non-antibody-producing and have high fusion efficiency and enzyme deficiencies that render then incapable of growing in certain selective media that support the growth of only the desired fused cells (hybridomas). Typically, the fusion partner includes a property that allows selection of the resulting hybridomas using specific media. For example, fusion partners can be hypoxanthine/aminopterin/thymidine (HAT)-sensitive. Methods for generating hybrids of antibody-producing spleen or lymph node cells and myeloma cells usually comprise mixing somatic cells with myeloma cells in the presence of an agent or agents (chemical or electrical) that promote the fusion of cell membranes. Next, selection of hybridomas can be performed by culturing the cells by single clone dilution in microtiter plates, followed by testing the individual clonal supernatants (after about two to three weeks) for the desired reactivity. Fusion procedures for making hybridomas, immunization protocols, and techniques for isolation of immunized splenocytes for fusion are known in the art.

[0180] Other techniques for producing monoclonal antibodies include the viral or oncogenic transformation of B-lymphocytes, a molecular cloning approach may be used to generate a nucleic acid or polypeptide, the selected lymphocyte antibody method (SLAM) (see, e.g., Babcook et al., Proc. Natl. Acad. Sci. USA 93:7843-7848 (1996), the preparation of combinatorial immunoglobulin phagemid libraries from RNA isolated from the spleen of the immunized animal and selection of phagemids expressing appropriate antibodies, or producing a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination (see, e.g., U.S. 6,091,001).

[0181] Monoclonal antibodies may be further purified using filtration, centrifugation, and various chromatographic methods such as HPLC or affinity chromatography. Monoclonal antibodies may be further screened or optimized for properties relating to specificity, avidity, half-life, immunogenicity, binding association, binding disassociation, or overall functional properties relative to being a treatment for infection. Thus, monoclonal antibodies may have alterations in the amino acid sequence of CDRs, including insertions, deletions, or substitutions with a conserved or non-conserved amino acid.

[0182] The immunogenicity of a particular immunogen composition can be enhanced by the use of non-specific stimulators of the immune response, known as adjuvants. Adjuvants that may be used in accordance with embodiments include, but are not limited to, IL-1, IL-2, IL-4, IL-7, IL-12, -interferon, GMCSP, BCG, aluminum hydroxide, MDP compounds, such as thur- MDP and nor-MDP, CGP (MTP-PE), lipid A, and monophosphoryl lipid A (MPL). Exemplary adjuvants may include complete Freund’s adjuvant (a non-specific stimulator of the immune response containing killed Mycobacterium tuberculosis), incomplete Freund’s adjuvants, and/or aluminum hydroxide adjuvant. In addition to adjuvants, it may be desirable to co administer biologic response modifiers (BRM), such as but not limited to, Cimetidine (CIM; 1200 mg/d) (Smith/Kline, PA); low-dose Cyclophosphamide (CYP; 300 mg/m2) (Johnson/ Mead, NJ), cytokines such as b-interferon, IL-2, or IL-12, or genes encoding proteins involved in immune helper functions, such as B-7.A phage-display system can be used to expand antibody molecule populations in vitro. Saiki, et ak, Nature 324:163 (1986); Scharf et ah, Science 233:1076 (1986); U.S. Pat. Nos. 4,683,195 and 4,683,202; Yang et ak, J Mol Biol. 254:392 (1995); Barbas, III et ak, Methods: Comp. Meth Enzymoh (1995) 8:94; Barbas, III et ak, Proc Natl Acad Sci USA 88:7978 (1991).

B. Fully Human Antibody Production

[0183] Methods are available for making fully human antibodies. Using fully human antibodies can minimize the immunogenic and allergic responses that may be caused by administering non-human monoclonal antibodies to humans as therapeutic agents. In one embodiment, human antibodies may be produced in a non-human transgenic animal, e.g., a transgenic mouse capable of producing multiple isotypes of human antibodies to protein (e.g., IgG, IgA, and/or IgE) by undergoing V-D-J recombination and isotype switching. Accordingly, this aspect applies to antibodies, antibody fragments, and pharmaceutical compositions thereof, but also non-human transgenic animals, B-cells, host cells, and hybridomas that produce monoclonal antibodies. Applications of humanized antibodies include, but are not limited to, detect a cell expressing an anticipated protein, either in vivo or in vitro, pharmaceutical preparations containing the antibodies of the present invention, and methods of treating disorders by administering the antibodies.

[0184] Fully human antibodies can be produced by immunizing transgenic animals (usually mice) that are capable of producing a repertoire of human antibodies in the absence of endogenous immunoglobulin production. Antigens for this purpose typically have six or more contiguous amino acids, and optionally are conjugated to a carrier, such as a hapten. See, for example, Jakobovits et al., Proc. Natl. Acad. Sci. USA 90:2551-2555 (1993); Jakobovits et ah, Nature 362:255-258 (1993); Bruggermann et al., Year in Immunol. 7:33 (1993). In one example, transgenic animals are produced by incapacitating the endogenous mouse immunoglobulin loci encoding the mouse heavy and light immunoglobulin chains therein, and inserting into the mouse genome large fragments of human genome DNA containing loci that encode human heavy and light chain proteins. Partially modified animals, which have less than the full complement of human immunoglobulin loci, are then crossbred to obtain an animal having all of the desired immune system modifications. When administered an immunogen, these transgenic animals produce antibodies that are immunospecific for the immunogen but have human rather than murine amino acid sequences, including the variable regions. For further details of such methods, see, for example, International Patent Application Publication Nos. WO 96/33735 and WO 94/02602, which are hereby incorporated by reference in their entirety. Additional methods relating to transgenic mice for making human antibodies are described in U.S. Pat. Nos. 5,545,807; 6,713,610; 6,673,986; 6,162,963; 6,300,129; 6,255,458; 5,877,397; 5,874,299 and 5,545,806; in International Patent Application Publication Nos. WO 91/10741 and WO 90/04036; and in European Patent Nos. EP 546073B1 and EP 546073A1, all of which are hereby incorporated by reference in their entirety for all purposes.

[0185] The transgenic mice described above, referred to herein as “HuMAb” mice, contain a human immunoglobulin gene minilocus that encodes unrearranged human heavy (m and g) and K light chain immunoglobulin sequences, together with targeted mutations that inactivate the endogenous m and k chain loci (Lonberg et al., Nature 368:856-859 (1994)). Accordingly, the mice exhibit reduced expression of mouse IgM or k chains and in response to immunization, the introduced human heavy and light chain transgenes undergo class switching and somatic mutation to generate high affinity human IgG k monoclonal antibodies (Lonberg et al., supra; Lonberg and Huszar, Intern. Ref. Immunol. 13:65-93 (1995); Harding and Lonberg, Ann. N.Y. Acad. Sci. 764:536-546 (1995)). The preparation of HuMAb mice is described in detail in Taylor et al., Nucl. Acids Res. 20:6287-6295 (1992); Chen et al., Int. Immunol. 5:647-656 (1993); Tuaillon et al., J. Immunol. 152:2912-2920 (1994); Lonberg et al., supra; Lonberg, Handbook of Exp. Pharmacol. 113:49-101 (1994); Taylor et al., Int. Immunol. 6:579-591 (1994); Lonberg and Huszar, Intern. Ref. Immunol. 13:65-93 (1995); Harding and Lonberg, Ann. N. Y. Acad. Sci. 764:536-546 (1995); Fishwild et al., Nat. Biotechnol. 14:845-851 (1996); the foregoing references are herein incorporated by reference in their entirety for all purposes. See further, U.S. Pat. Nos. 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,789,650; 5,877,397; 5,661,016; 5,814,318; 5,874,299; 5,770,429; and 5,545,807; as well as International Patent Application Publication Nos. WO 93/1227; WO 92/22646; and WO 92/03918, the disclosures of all of which are hereby incorporated by reference in their entirety for all purposes. Technologies utilized for producing human antibodies in these transgenic mice are disclosed also in WO 98/24893, and Mendez et al., Nat. Genetics 15:146-156 (1997), which are herein incorporated by reference. For example, the HCo7 and HCol2 transgenic mice strains can be used to generate human antibodies.

[0186] Using hybridoma technology, antigen-specific humanized monoclonal antibodies with the desired specificity can be produced and selected from the transgenic mice such as those described above. Such antibodies may be cloned and expressed using a suitable vector and host cell, or the antibodies can be harvested from cultured hybridoma cells. Fully human antibodies can also be derived from phage-display libraries (as disclosed in Hoogenboom et al., J. Mol. Biol. 227:381 (1991); and Marks et al., J. Mol. Biol. 222:581 (1991)). One such technique is described in International Patent Application Publication No. WO 99/10494 (herein incorporated by reference), which describes the isolation of high affinity and functional agonistic antibodies for MPL- and msk-receptors using such an approach.

C. Antibody Fragments Production

[0187] Antibody fragments that retain the ability to recognize the antigen of interest will also find use herein. A number of antibody fragments are known in the art that comprise antigen binding sites capable of exhibiting immunological binding properties of an intact antibody molecule and can be subsequently modified by methods known in the arts. Functional fragments, including only the variable regions of the heavy and light chains, can also be produced using standard techniques such as recombinant production or preferential proteolytic cleavage of immunoglobulin molecules. These fragments are known as Fv. See, e.g., Inbar et al., Proc. Nat. Acad. Sci. USA 69:2659-2662 (1972); Hochman et al., Biochem. 15:2706-2710 (1976); and Ehrlich et al., Biochem. 19:4091-4096 (1980). [0188] Single-chain variable fragments (scFvs) may be prepared by fusing DNA encoding a peptide linker between DNAs encoding the two variable domain polypeptides (VL and VH). scFvs can form antigen-binding monomers, or they can form multimers (e.g., dimers, trimers, or tetramers), depending on the length of a flexible linker between the two variable domains (Kortt et ak, Prot. Eng. 10:423 (1997); Kort et ak, Biomok Eng. 18:95-108 (2001)). By combining different VL- and VH-comprising polypeptides, one can form multimeric scFvs that bind to different epitopes (Kriangkum et ak, Biomok Eng. 18:31-40 (2001)). Antigen-binding fragments are typically produced by recombinant DNA methods known to those skilled in the art. Although the two domains of the Fv fragment, VL and VH, are coded for by separate genes, they can be joined using recombinant methods by a synthetic linker that enables them to be made as a single chain polypeptide (known as single chain Fv (sFv or scFv); see e.g., Bird et ak, Science 242:423-426 (1988); and Huston et ak, Proc. Natl. Acad. Sci. EISA 85:5879-5883 (1988). Design criteria include determining the appropriate length to span the distance between the C-terminus of one chain and the N-terminus of the other, wherein the linker is generally formed from small hydrophilic amino acid residues that do not tend to coil or form secondary structures. Suitable linkers generally comprise polypeptide chains of alternating sets of glycine and serine residues, and may include glutamic acid and lysine residues inserted to enhance solubility. Antigen-binding fragments are screened for utility in the same manner as intact antibodies. Such fragments include those obtained by amino-terminal and/or carboxy-terminal deletions, where the remaining amino acid sequence is substantially identical to the corresponding positions in the naturally occurring sequence deduced, for example, from a full- length cDNA sequence.

[0189] Antibodies may also be generated using peptide analogs of the epitopic determinants disclosed herein, which may consist of non-peptide compounds having properties analogous to those of the template peptide. These types of non-peptide compound are termed “peptide mimetics” or “peptidomimetics”. Fauchere, J. Adv. Drug Res. 15:29 (1986); Veber and Freidinger TINS p. 392 (1985); and Evans et ak, J. Med. Chem. 30:1229 (1987). Liu et ak (2003) also describe “antibody like binding peptidomimetics” (ABiPs), which are peptides that act as pared-down antibodies and have certain advantages of longer serum half-life as well as less cumbersome synthesis methods. These analogs can be peptides, non-peptides or combinations of peptide and non-peptide regions. Fauchere, Adv. Drug Res. 15:29 (1986); Veber and Freidiner, TINS p. 392 (1985); and Evans et ak, J. Med. Chem. 30:1229 (1987), which are incorporated herein by reference in their entirety for any purpose. Peptide mimetics that are structurally similar to therapeutically useful peptides may be used to produce a similar therapeutic or prophylactic effect. Such compounds are often developed with the aid of computerized molecular modeling. Generally, peptidomimetics of the invention are proteins that are structurally similar to an antibody displaying a desired biological activity, such as the ability to bind a protein, but have one or more peptide linkages optionally replaced by a linkage selected from: — CH2NH — , — CH2S — , — CH2 — CH2 — , — CH=CH— (cis and trans), — COCH2 — , — CH(OH)CH2 — , and — CH2SO — by methods well known in the art. Systematic substitution of one or more amino acids of a consensus sequence with a D-amino acid of the same type (e.g., D-lysine in place of L-lysine) may be used in certain embodiments of the invention to generate more stable proteins. In addition, constrained peptides comprising a consensus sequence or a substantially identical consensus sequence variation may be generated by methods known in the art (Rizo and Gierasch, Ann. Rev. Biochem. 61:387 (1992), incorporated herein by reference), for example, by adding internal cysteine residues capable of forming intramolecular disulfide bridges which cyclize the peptide.

[0190] Once generated, a phage display library can be used to improve the immunological binding affinity of the Fab molecules using known techniques. See, e.g., Figini et ak, J. Mol. Biol. 239:68 (1994). The coding sequences for the heavy and light chain portions of the Fab molecules selected from the phage display library can be isolated or synthesized and cloned into any suitable vector or replicon for expression. Any suitable expression system can be used.

VIII. Polypeptide Expression

[0191] In some aspects, there are nucleic acid molecule encoding polypeptides or peptides of the disclosure (e.g antibodies, TCR genes, and immunogenic peptides). These may be generated by methods known in the art, e.g., isolated from B cells of mice that have been immunized and isolated, phage display, expressed in any suitable recombinant expression system and allowed to assemble to form antibody molecules or by recombinant methods.

1. Expression

[0192] The nucleic acid molecules may be used to express large quantities of polypeptides. If the nucleic acid molecules are derived from a non-human, non-transgenic animal, the nucleic acid molecules may be used for humanization of the antibody or TCR genes.

2. Vectors [0193] In some aspects, contemplated are expression vectors comprising a nucleic acid molecule encoding a polypeptide of the desired sequence or a portion thereof (e.g., a fragment containing one or more CDRs or one or more variable region domains). Expression vectors comprising the nucleic acid molecules may encode the heavy chain, light chain, or the antigen binding portion thereof. In some aspects, expression vectors comprising nucleic acid molecules may encode fusion proteins, modified antibodies, antibody fragments, and probes thereof. In addition to control sequences that govern transcription and translation, vectors and expression vectors may contain nucleic acid sequences that serve other functions as well.

[0194] To express the polypeptides or peptides of the disclosure, DNAs encoding the polypeptides or peptides are inserted into expression vectors such that the gene area is operatively linked to transcriptional and translational control sequences. In some aspects, a vector that encodes a functionally complete human CH or CL immunoglobulin sequence with appropriate restriction sites engineered so that any VH or VL sequence can be easily inserted and expressed. In some aspects, a vector that encodes a functionally complete human TCR alpha or TCR beta sequence with appropriate restriction sites engineered so that any variable sequence or CDR1, CDR2, and/or CDR3 can be easily inserted and expressed. Typically, expression vectors used in any of the host cells contain sequences for plasmid or virus maintenance and for cloning and expression of exogenous nucleotide sequences. Such sequences, collectively referred to as “flanking sequences” typically include one or more of the following operatively linked nucleotide sequences: a promoter, one or more enhancer sequences, an origin of replication, a transcriptional termination sequence, a complete intron sequence containing a donor and acceptor splice site, a sequence encoding a leader sequence for polypeptide secretion, a ribosome binding site, a polyadenylation sequence, a polylinker region for inserting the nucleic acid encoding the polypeptide to be expressed, and a selectable marker element. Such sequences and methods of using the same are well known in the art.

3. Expression Systems

[0195] Numerous expression systems exist that comprise at least a part or all of the expression vectors discussed above. Prokaryote- and/or eukaryote-based systems can be employed for use with an embodiment to produce nucleic acid sequences, or their cognate polypeptides, proteins and peptides. Commercially and widely available systems include in but are not limited to bacterial, mammalian, yeast, and insect cell systems. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. Those skilled in the art are able to express a vector to produce a nucleic acid sequence or its cognate polypeptide, protein, or peptide using an appropriate expression system.

4. Methods of Gene Transfer

[0196] Suitable methods for nucleic acid delivery to effect expression of compositions are anticipated to include virtually any method by which a nucleic acid (e.g., DNA, including viral and nonviral vectors) can be introduced into a cell, a tissue or an organism, as described herein or as would be known to one of ordinary skill in the art. Such methods include, but are not limited to, direct delivery of DNA such as by injection (U.S. Patents 5,994,624,5,981,274, 5,945,100, 5,780,448, 5,736,524, 5,702,932, 5,656,610, 5,589,466 and 5,580,859, each incorporated herein by reference), including microinjection (Harland and Weintraub, 1985; U.S. Patent 5,789,215, incorporated herein by reference); by electroporation (U.S. Patent No. 5,384,253, incorporated herein by reference); by calcium phosphate precipitation (Graham and Van Der Eb, 1973; Chen and Okayama, 1987; Rippe et ah, 1990); by using DEAE dextran followed by polyethylene glycol (Gopal, 1985); by direct sonic loading (Fechheimer et ah, 1987); by liposome mediated transfection (Nicolau and Sene, 1982; Fraley et ah, 1979; Nicolau et ah, 1987; Wong et ah, 1980; Kaneda et ah, 1989; Kato et ah, 1991); by microprojectile bombardment (PCT Application Nos. WO 94/09699 and 95/06128; U.S. Patents 5,610,042; 5,322,783, 5,563,055, 5,550,318, 5,538,877 and 5,538,880, and each incorporated herein by reference); by agitation with silicon carbide fibers (Kaeppler et ah, 1990; U.S. Patents 5,302,523 and 5,464,765, each incorporated herein by reference); by Agrobacterium mediated transformation (U.S. Patents 5,591,616 and 5,563,055, each incorporated herein by reference); or by PEG mediated transformation of protoplasts (Omirulleh et ah, 1993; U.S. Patents 4,684,611 and 4,952,500, each incorporated herein by reference); by desiccation/inhibition mediated DNA uptake (Potrykus et al., 1985). Other methods include viral transduction, such as gene transfer by lentiviral or retroviral transduction.

5. Host Cells

[0197] In another aspect, contemplated are the use of host cells into which a recombinant expression vector has been introduced. Antibodies can be expressed in a variety of cell types. An expression construct encoding an antibody can be transfected into cells according to a variety of methods known in the art. Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. Some vectors may employ control sequences that allow it to be replicated and/or expressed in both prokaryotic and eukaryotic cells. In certain aspects, the antibody expression construct can be placed under control of a promoter that is linked to T-cell activation, such as one that is controlled by NFAT- 1 or NF-KB, both of which are transcription factors that can be activated upon T-cell activation. Control of antibody expression allows T cells, such as tumor- targeting T cells, to sense their surroundings and perform real-time modulation of cytokine signaling, both in the T cells themselves and in surrounding endogenous immune cells. One of skill in the art would understand the conditions under which to incubate host cells to maintain them and to permit replication of a vector. Also understood and known are techniques and conditions that would allow large-scale production of vectors, as well as production of the nucleic acids encoded by vectors and their cognate polypeptides, proteins, or peptides.

[0198] For stable transfection of mammalian cells, it is known, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a selectable marker (e.g., for resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die), among other methods known in the arts.

B. Isolation

[0199] The nucleic acid molecule encoding either or both of the entire heavy and light chains of an antibody or the variable regions thereof may be obtained from any source that produces antibodies. Methods of isolating mRNA encoding an antibody are well known in the art. See e.g., Sambrook et ah, supra. The sequences of human heavy and light chain constant region genes are also known in the art. See, e.g., Kabat et ah, 1991, supra. Nucleic acid molecules encoding the full-length heavy and/or light chains may then be expressed in a cell into which they have been introduced and the antibody isolated.

IX. Additional Therapies

A. Immunotherapy [0200] In some embodiments, the methods comprise administration of an additional therapy. In some embodiments, the additional therapy comprises a cancer immunotherapy. Cancer immunotherapy (sometimes called immuno-oncology, abbreviated IO) is the use of the immune system to treat cancer. Immunotherapies can be categorized as active, passive or hybrid (active and passive). These approaches exploit the fact that cancer cells often have molecules on their surface that can be detected by the immune system, known as tumor- associated antigens (TAAs); they are often proteins or other macromolecules (e.g. carbohydrates). Active immunotherapy directs the immune system to attack tumor cells by targeting TAAs. Passive immunotherapies enhance existing anti-tumor responses and include the use of monoclonal antibodies, lymphocytes and cytokines. Immunotherapies are known in the art, and some are described below.

1. Checkpoint Inhibitors and Combination Treatment

[0201] Embodiments of the disclosure may include administration of immune checkpoint inhibitors, which are further described below.

1. PD-1, PDL1, and PDL2 inhibitors

[0202] PD-1 can act in the tumor microenvironment where T cells encounter an infection or tumor. Activated T cells upregulate PD-1 and continue to express it in the peripheral tissues. Cytokines such as IFN-gamma induce the expression of PDL1 on epithelial cells and tumor cells. PDL2 is expressed on macrophages and dendritic cells. The main role of PD-1 is to limit the activity of effector T cells in the periphery and prevent excessive damage to the tissues during an immune response. Inhibitors of the disclosure may block one or more functions of PD-1 and/or PDL1 activity.

[0203] Alternative names for “PD-1” include CD279 and SLEB2. Alternative names for “PDL1” include B7-H1, B7-4, CD274, and B7-H. Alternative names for “PDL2” include B7- DC, Btdc, and CD273. In some embodiments, PD-1, PDL1, and PDL2 are human PD-1, PDL1 and PDL2.

[0204] In some embodiments, the PD-1 inhibitor is a molecule that inhibits the binding of PD-1 to its ligand binding partners. In a specific aspect, the PD-1 ligand binding partners are PDL1 and/or PDL2. In another embodiment, a PDL1 inhibitor is a molecule that inhibits the binding of PDL1 to its binding partners. In a specific aspect, PDL1 binding partners are PD-1 and/or B7-1. In another embodiment, the PDL2 inhibitor is a molecule that inhibits the binding of PDL2 to its binding partners. In a specific aspect, a PDL2 binding partner is PD-1. The inhibitor may be an antibody, an antigen binding fragment thereof, an immunoadhesin, a fusion protein, or oligopeptide. Exemplary antibodies are described in U.S. Patent Nos. 8,735,553, 8,354,509, and 8,008,449, all incorporated herein by reference. Other PD-1 inhibitors for use in the methods and compositions provided herein are known in the art such as described in U.S. Patent Application Nos. US2014/0294898, US2014/022021, and US2011/0008369, all incorporated herein by reference.

[0205] In some embodiments, the PD-1 inhibitor is an anti-PD-1 antibody (e.g., a human antibody, a humanized antibody, or a chimeric antibody). In some embodiments, the anti-PD- 1 antibody is selected from the group consisting of nivolumab, pembrolizumab, and pidilizumab. In some embodiments, the PD-1 inhibitor is an immunoadhesin (e.g., an immunoadhesin comprising an extracellular or PD-1 binding portion of PDL1 or PDL2 fused to a constant region (e.g., an Fc region of an immunoglobulin sequence). In some embodiments, the PDL1 inhibitor comprises AMP- 224. Nivolumab, also known as MDX-1106-04, MDX- 1106, ONO-4538, BMS-936558, and OPDIVO®, is an anti-PD-1 antibody described in W02006/121168. Pembrolizumab, also known as MK-3475, Merck 3475, lambrolizumab, KEYTRUDA®, and SCH-900475, is an anti-PD-1 antibody described in W02009/114335. Pidilizumab, also known as CT-011, hBAT, or hBAT-1, is an anti-PD-1 antibody described in W02009/101611. AMP -224, also known as B7-DCIg, is a PDL2-Fc fusion soluble receptor described in W02010/027827 and WO2011/066342. Additional PD-1 inhibitors include MEDI0680, also known as AMP-514, and REGN2810.

[0206] In some embodiments, the immune checkpoint inhibitor is a PDL1 inhibitor such as Durvalumab, also known as MEDI4736, atezolizumab, also known as MPDL3280A, avelumab, also known as MSB00010118C, MDX-1105, BMS-936559, or combinations thereof. In certain aspects, the immune checkpoint inhibitor is a PDL2 inhibitor such as rHIgM12B7.

[0207] In some embodiments, the inhibitor comprises the heavy and light chain CDRs or VRs of nivolumab, pembrolizumab, or pidilizumab. Accordingly, in one embodiment, the inhibitor comprises the CDR1, CDR2, and CDR3 domains of the VH region of nivolumab, pembrolizumab, or pidilizumab, and the CDR1, CDR2 and CDR3 domains of the VL region of nivolumab, pembrolizumab, or pidilizumab. In another embodiment, the antibody competes for binding with and/or binds to the same epitope on PD-1, PDL1, or PDL2 as the above- mentioned antibodies. In another embodiment, the antibody has at least about 70, 75, 80, 85, 90, 95, 97, or 99% (or any derivable range therein) variable region amino acid sequence identity with the above-mentioned antibodies. b. CTLA-4, B7-1, and B7-2

[0208] Another immune checkpoint that can be targeted in the methods provided herein is the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152. The complete cDNA sequence of human CTLA-4 has the Genbank accession number LI 5006. CTLA-4 is found on the surface of T cells and acts as an “off’ switch when bound to B7-1 (CD80) or B7-2 (CD86) on the surface of antigen-presenting cells. CTLA4 is a member of the immunoglobulin superfamily that is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to B7-1 and B7-2 on antigen-presenting cells. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA- 4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Inhibitors of the disclosure may block one or more functions of CTLA-4, B7-1, and/or B7-2 activity. In some embodiments, the inhibitor blocks the CTLA-4 and B7-1 interaction. In some embodiments, the inhibitor blocks the CTLA-4 and B7-2 interaction.

[0209] In some embodiments, the immune checkpoint inhibitor is an anti-CTLA-4 antibody (e.g., a human antibody, a humanized antibody, or a chimeric antibody), an antigen binding fragment thereof, an immunoadhesin, a fusion protein, or oligopeptide.

[0210] Anti-human-CTLA-4 antibodies (or VH and/or VL domains derived therefrom) suitable for use in the present methods can be generated using methods well known in the art. Alternatively, art recognized anti-CTLA-4 antibodies can be used. For example, the anti- CTLA-4 antibodies disclosed in: US 8,119,129, WO 01/14424, WO 98/42752; WO 00/37504 (CP675,206, also known as tremelimumab; formerly ticilimumab), U.S. Patent No. 6,207,156; Hurwitz et ah, 1998; can be used in the methods disclosed herein. The teachings of each of the aforementioned publications are hereby incorporated by reference. Antibodies that compete with any of these art-recognized antibodies for binding to CTLA-4 also can be used. For example, a humanized CTLA-4 antibody is described in International Patent Application No. WO200 1/014424, W02000/037504, and U.S. Patent No. 8,017,114; all incorporated herein by reference.

[0211] A further anti-CTLA-4 antibody useful as a checkpoint inhibitor in the methods and compositions of the disclosure is ipilimumab (also known as 10D1, MDX- 010, MDX- 101, and Yervoy®) or antigen binding fragments and variants thereof (see, e.g., WOO 1/14424). [0212] In some embodiments, the inhibitor comprises the heavy and light chain CDRs or VRs of tremelimumab or ipilimumab. Accordingly, in one embodiment, the inhibitor comprises the CDR1, CDR2, and CDR3 domains of the VH region of tremelimumab or ipilimumab, and the CDR1, CDR2 and CDR3 domains of the VL region of tremelimumab or ipilimumab. In another embodiment, the antibody competes for binding with and/or binds to the same epitope on PD- 1, B7-1, or B7-2 as the above- mentioned antibodies. In another embodiment, the antibody has at least about 70, 75, 80, 85, 90, 95, 97, or 99% (or any derivable range therein) variable region amino acid sequence identity with the above-mentioned antibodies.

2. Inhibition of co-stimulatory molecules

[0213] In some embodiments, the immunotherapy comprises an inhibitor of a co-stimulatory molecule. In some embodiments, the inhibitor comprises an inhibitor of B7-1 (CD80), B7-2 (CD86), CD28, ICOS, 0X40 (TNFRSF4), 4-1BB (CD137; TNFRSF9), CD40L (CD40LG), GITR (TNFRSF18), and combinations thereof. Inhibitors include inhibitory antibodies, polypeptides, compounds, and nucleic acids.

2. Dendritic cell therapy

[0214] Dendritic cell therapy provokes anti-tumor responses by causing dendritic cells to present tumor antigens to lymphocytes, which activates them, priming them to kill other cells that present the antigen. Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. In cancer treatment they aid cancer antigen targeting. One example of cellular cancer therapy based on dendritic cells is sipuleucel-T.

[0215] One method of inducing dendritic cells to present tumor antigens is by vaccination with autologous tumor lysates or short peptides (small parts of protein that correspond to the protein antigens on cancer cells). These peptides are often given in combination with adjuvants (highly immunogenic substances) to increase the immune and anti-tumor responses. Other adjuvants include proteins or other chemicals that attract and/or activate dendritic cells, such as granulocyte macrophage colony-stimulating factor (GM-CSF). [0216] Dendritic cells can also be activated in vivo by making tumor cells express GM-CSF. This can be achieved by either genetically engineering tumor cells to produce GM-CSF or by infecting tumor cells with an oncolytic virus that expresses GM-CSF.

[0217] Another strategy is to remove dendritic cells from the blood of a patient and activate them outside the body. The dendritic cells are activated in the presence of tumor antigens, which may be a single tumor-specific peptide/protein or a tumor cell lysate (a solution of broken down tumor cells). These cells (with optional adjuvants) are infused and provoke an immune response.

[0218] Dendritic cell therapies include the use of antibodies that bind to receptors on the surface of dendritic cells. Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. Dendritic cell receptors such as TLR3, TLR7, TLR8 or CD40 have been used as antibody targets.

3. CAR-T cell therapy

[0219] Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors) are engineered receptors that combine a new specificity with an immune cell to target cancer cells. Typically, these receptors graft the specificity of a monoclonal antibody onto a T cell. The receptors are called chimeric because they are fused of parts from different sources. CAR-T cell therapy refers to a treatment that uses such transformed cells for cancer therapy.

[0220] The basic principle of CAR-T cell design involves recombinant receptors that combine antigen-binding and T-cell activating functions. The general premise of CAR-T cells is to artificially generate T-cells targeted to markers found on cancer cells. Scientists can remove T-cells from a person, genetically alter them, and put them back into the patient for them to attack the cancer cells. Once the T cell has been engineered to become a CAR-T cell, it acts as a “living drug”. CAR-T cells create a link between an extracellular ligand recognition domain to an intracellular signalling molecule which in turn activates T cells. The extracellular ligand recognition domain is usually a single-chain variable fragment (scFv). An important aspect of the safety of CAR-T cell therapy is how to ensure that only cancerous tumor cells are targeted, and not normal cells. The specificity of CAR-T cells is determined by the choice of molecule that is targeted.

[0221] Exemplary CAR-T therapies include Tisagenlecleucel (Kymriah) and Axicabtagene ciloleucel (Yescarta). In some embodiments, the CAR-T therapy targets CD 19. 4. Cytokine therapy

[0222] Cytokines are proteins produced by many types of cells present within a tumor. They can modulate immune responses. The tumor often employs them to allow it to grow and reduce the immune response. These immune-modulating effects allow them to be used as drugs to provoke an immune response. Two commonly used cytokines are interferons and interleukins. [0223] Interferons are produced by the immune system. They are usually involved in anti viral response, but also have use for cancer. They fall in three groups: type I (IFNa and IFNP), type II (IFNy) and type III (IFNk)

[0224] Interleukins have an array of immune system effects. IL-2 is an exemplary interleukin cytokine therapy.

5. Adoptive T-cell therapy

[0225] Adoptive T cell therapy is a form of passive immunization by the transfusion of T- cells (adoptive cell transfer). They are found in blood and tissue and usually activate when they find foreign pathogens. Specifically they activate when the T-cell's surface receptors encounter cells that display parts of foreign proteins on their surface antigens. These can be either infected cells, or antigen presenting cells (APCs). They are found in normal tissue and in tumor tissue, where they are known as tumor infiltrating lymphocytes (TILs). They are activated by the presence of APCs such as dendritic cells that present tumor antigens. Although these cells can attack the tumor, the environment within the tumor is highly immunosuppressive, preventing immune-mediated tumour death. [60]

[0226] Multiple ways of producing and obtaining tumour targeted T-cells have been developed. T-cells specific to a tumor antigen can be removed from a tumor sample (TILs) or filtered from blood. Subsequent activation and culturing is performed ex vivo, with the results reinfused. Activation can take place through gene therapy, or by exposing the T cells to tumor antigens.

B. Chemotherapies

[0227] In some embodiments, the additional therapy comprises a chemotherapy. Suitable classes of chemotherapeutic agents include (a) Alkylating Agents, such as nitrogen mustards (e.g., mechlorethamine, cylophosphamide, ifosfamide, melphalan, chlorambucil), ethylenimines and methylmelamines (e.g., hexamethylmelamine, thiotepa), alkyl sulfonates (e.g., busulfan), nitrosoureas (e.g., carmustine, lomustine, chlorozoticin, streptozocin) and triazines (e.g., dicarbazine), (b) Antimetabolites, such as folic acid analogs (e.g., methotrexate), pyrimidine analogs (e.g., 5-fluorouracil, floxuridine, cytarabine, azauridine) and purine analogs and related materials (e.g., 6-mercaptopurine, 6-thioguanine, pentostatin), (c) Natural Products, such as vinca alkaloids (e.g., vinblastine, vincristine), epipodophylotoxins (e.g., etoposide, teniposide), antibiotics (e.g., dactinomycin, daunorubicin, doxorubicin, bleomycin, plicamycin and mitoxanthrone), enzymes (e.g., L-asparaginase), and biological response modifiers (e.g., Interferon-a), and (d) Miscellaneous Agents, such as platinum coordination complexes (e.g., cisplatin, carboplatin), substituted ureas (e.g., hydroxyurea), methylhydiazine derivatives (e.g., procarbazine), and adreocortical suppressants (e.g., taxol and mitotane). In some embodiments, cisplatin is a particularly suitable chemotherapeutic agent.

[0228] Cisplatin has been widely used to treat cancers such as, for example, metastatic testicular or ovarian carcinoma, advanced bladder cancer, head or neck cancer, cervical cancer, lung cancer or other tumors. Cisplatin is not absorbed orally and must therefore be delivered via other routes such as, for example, intravenous, subcutaneous, intratumoral or intraperitoneal injection. Cisplatin can be used alone or in combination with other agents, with efficacious doses used in clinical applications including about 15 mg/m ² to about 20 mg/m ² for 5 days every three weeks for a total of three courses being contemplated in certain embodiments. In some embodiments, the amount of cisplatin delivered to the cell and/or subject in conjunction with the construct comprising an Egr-1 promoter operably linked to a polynucleotide encoding the therapeutic polypeptide is less than the amount that would be delivered when using cisplatin alone.

[0229] Other suitable chemotherapeutic agents include antimicrotubule agents, e.g., Paclitaxel (“Taxol”) and doxorubicin hydrochloride (“doxorubicin”). The combination of an Egr-1 promoter/TNFa construct delivered via an adenoviral vector and doxorubicin was determined to be effective in overcoming resistance to chemotherapy and/or TNF-a, which suggests that combination treatment with the construct and doxorubicin overcomes resistance to both doxorubicin and TNF-a.

[0230] Doxorubicin is absorbed poorly and is preferably administered intravenously. In certain embodiments, appropriate intravenous doses for an adult include about 60 mg/m ² to about 75 mg/m ² at about 21-day intervals or about 25 mg/m ² to about 30 mg/m ² on each of 2 or 3 successive days repeated at about 3 week to about 4 week intervals or about 20 mg/m ² once a week. The lowest dose should be used in elderly patients, when there is prior bone- marrow depression caused by prior chemotherapy or neoplastic marrow invasion, or when the drug is combined with other myelopoietic suppressant drugs. [0231] Nitrogen mustards are another suitable chemotherapeutic agent useful in the methods of the disclosure. A nitrogen mustard may include, but is not limited to, mechlorethamine (HN2), cyclophosphamide and/or ifosfamide, melphalan (L-sarcolysin), and chlorambucil. Cyclophosphamide (CYTOXAN®) is available from Mead Johnson and NEOSTAR® is available from Adria), is another suitable chemotherapeutic agent. Suitable oral doses for adults include, for example, about 1 mg/kg/day to about 5 mg/kg/day, intravenous doses include, for example, initially about 40 mg/kg to about 50 mg/kg in divided doses over a period of about 2 days to about 5 days or about 10 mg/kg to about 15 mg/kg about every 7 days to about 10 days or about 3 mg/kg to about 5 mg/kg twice a week or about 1.5 mg/kg/day to about 3 mg/kg/day. Because of adverse gastrointestinal effects, the intravenous route is preferred. The drug also sometimes is administered intramuscularly, by infiltration or into body cavities.

[0232] Additional suitable chemotherapeutic agents include pyrimidine analogs, such as cytarabine (cytosine arabinoside), 5-fluorouracil (fluouracil; 5-FU) and floxuridine (fluorode- oxyuridine; FudR). 5-FU may be administered to a subject in a dosage of anywhere between about 7.5 to about 1000 mg/m2. Further, 5-FU dosing schedules may be for a variety of time periods, for example up to six weeks, or as determined by one of ordinary skill in the art to which this disclosure pertains.

[0233] Gemcitabine diphosphate (GEMZAR®, Eli Lilly & Co., “gemcitabine”), another suitable chemotherapeutic agent, is recommended for treatment of advanced and metastatic pancreatic cancer, and will therefore be useful in the present disclosure for these cancers as well.

[0234] The amount of the chemotherapeutic agent delivered to the patient may be variable. In one suitable embodiment, the chemotherapeutic agent may be administered in an amount effective to cause arrest or regression of the cancer in a host, when the chemotherapy is administered with the construct. In other embodiments, the chemotherapeutic agent may be administered in an amount that is anywhere between 2 to 10,000 fold less than the chemotherapeutic effective dose of the chemotherapeutic agent. For example, the chemotherapeutic agent may be administered in an amount that is about 20 fold less, about 500 fold less or even about 5000 fold less than the chemotherapeutic effective dose of the chemotherapeutic agent. The chemotherapeutics of the disclosure can be tested in vivo for the desired therapeutic activity in combination with the construct, as well as for determination of effective dosages. For example, such compounds can be tested in suitable animal model systems prior to testing in humans, including, but not limited to, rats, mice, chicken, cows, monkeys, rabbits, etc. In vitro testing may also be used to determine suitable combinations and dosages, as described in the examples.

C. Radiotherapy

[0235] In some embodiments, the additional therapy or prior therapy comprises radiation, such as ionizing radiation. As used herein, “ionizing radiation” means radiation comprising particles or photons that have sufficient energy or can produce sufficient energy via nuclear interactions to produce ionization (gain or loss of electrons). An exemplary and preferred ionizing radiation is an x-radiation. Means for delivering x-radiation to a target tissue or cell are well known in the art.

D. Surgery

[0236] In some embodiments, the additional therapy comprises surgery. Approximately 60% of persons with cancer will undergo surgery of some type, which includes preventative, diagnostic or staging, curative, and palliative surgery. Curative surgery includes resection in which all or part of cancerous tissue is physically removed, excised, and/or destroyed and may be used in conjunction with other therapies, such as the treatment of the present embodiments, chemotherapy, radiotherapy, hormonal therapy, gene therapy, immunotherapy, and/or alternative therapies. Tumor resection refers to physical removal of at least part of a tumor. In addition to tumor resection, treatment by surgery includes laser surgery, cryosurgery, electrosurgery, and microscopically-controlled surgery (Mohs’ surgery).

[0237] Upon excision of part or all of cancerous cells, tissue, or tumor, a cavity may be formed in the body. Treatment may be accomplished by perfusion, direct injection, or local application of the area with an additional anti-cancer therapy. Such treatment may be repeated, for example, every 1, 2, 3, 4, 5, 6, or 7 days, or every 1, 2, 3, 4, and 5 weeks or every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 months (or any range derivable therein). These treatments may be of varying dosages as well. X. Formulations and Culture of the Cells

[0238] In particular embodiments, the cells of the disclosure may be specifically formulated and/or they may be cultured in a particular medium. The cells may be formulated in such a manner as to be suitable for delivery to a recipient without deleterious effects.

[0239] The medium in certain aspects can be prepared using a medium used for culturing animal cells as their basal medium, such as any of AIM V, X-VIVO-15, NeuroBasal, EGM2, TeSR, BME, BGJb, CMRL 1066, Glasgow MEM, Improved MEM Zinc Option, IMDM, Medium 199, Eagle MEM, aMEM, DMEM, Ham, RPMI-1640, and Fischer's media, as well as any combinations thereof, but the medium may not be particularly limited thereto as far as it can be used for culturing animal cells. Particularly, the medium may be xeno-free or chemically defined.

[0240] The medium can be a serum-containing or serum-free medium, or xeno-free medium. From the aspect of preventing contamination with heterogeneous animal-derived components, serum can be derived from the same animal as that of the stem cell(s). The serum-free medium refers to medium with no unprocessed or unpurified serum and accordingly, can include medium with purified blood-derived components or animal tissue-derived components (such as growth factors).

[0241] The medium may contain or may not contain any alternatives to serum. The alternatives to serum can include materials which appropriately contain albumin (such as lipid- rich albumin, bovine albumin, albumin substitutes such as recombinant albumin or a humanized albumin, plant starch, dextrans and protein hydrolysates), transferrin (or other iron transporters), fatty acids, insulin, collagen precursors, trace elements, 2-mercaptoethanol, 3'- thiolgiycerol, or equivalents thereto. The alternatives to serum can be prepared by the method disclosed in International Publication No. 98/30679, for example (incorporated herein in its entirety). Alternatively, any commercially available materials can be used for more convenience. The commercially available materials include knockout Serum Replacement (KSR), Chemically-defined Lipid concentrated (Gibco), and Glutamax (Gibco).

[0242] In certain embodiments, the medium may comprise one, two, three, four, five, six, seven, eight, nine, ten, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 or more of the following: Vitamins such as biotin; DL Alpha Tocopherol Acetate; DL Alpha-Tocopherol; Vitamin A (acetate); proteins such as BSA (bovine serum albumin) or human albumin, fatty acid free Fraction V; Catalase; Human Recombinant Insulin; Human Transferrin; Superoxide Dismutase; Other Components such as Corticosterone; D-Galactose; Ethanolamine HC1; Glutathione (reduced); L-Camitine HC1; Linoleic Acid; Linolenic Acid; Progesterone; Putrescine 2HC1; Sodium Selenite; and/or T3 (triodo-I-thyronine). . In specific embodiments, one or more of these may be explicitly excluded.

[0243] In some embodiments, the medium further comprises vitamins. In some embodiments, the medium comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13 of the following (and any range derivable therein): biotin, DL alpha tocopherol acetate, DL alpha-tocopherol, vitamin A, choline chloride, calcium pantothenate, pantothenic acid, folic acid nicotinamide, pyridoxine, riboflavin, thiamine, inositol, vitamin B12, or the medium includes combinations thereof or salts thereof. In some embodiments, the medium comprises or consists essentially of biotin, DL alpha tocopherol acetate, DL alpha-tocopherol, vitamin A, choline chloride, calcium pantothenate, pantothenic acid, folic acid nicotinamide, pyridoxine, riboflavin, thiamine, inositol, and vitamin B 12. In some embodiments, the vitamins include or consist essentially of biotin, DL alpha tocopherol acetate, DL alpha-tocopherol, vitamin A, or combinations or salts thereof. In some embodiments, the medium further comprises proteins. In some embodiments, the proteins comprise albumin or bovine serum albumin, a fraction of BSA, catalase, insulin, transferrin, superoxide dismutase, or combinations thereof. In some embodiments, the medium further comprises one or more of the following: corticosterone, D-Galactose, ethanolamine, glutathione, L-carnitine, linoleic acid, linolenic acid, progesterone, putrescine, sodium selenite, or triodo-I-thyronine, or combinations thereof. In some embodiments, the medium comprises one or more of the following: a B-27 ^® supplement, xeno-free B-27 ^® supplement, GS21™ supplement, or combinations thereof. In some embodiments, the medium comprises or futher comprises amino acids, monosaccharides, inorganic ions. In some embodiments, the amino acids comprise arginine, cystine, isoleucine, leucine, lysine, methionine, glutamine, phenylalanine, threonine, tryptophan, histidine, tyrosine, or valine, or combinations thereof. In some embodiments, the inorganic ions comprise sodium, potassium, calcium, magnesium, nitrogen, or phosphorus, or combinations or salts thereof. In some embodiments, the medium further comprises one or more of the following: molybdenum, vanadium, iron, zinc, selenium, copper, or manganese, or combinations thereof. In certain embodiments, the medium comprises or consists essentially of one or more vitamins discussed herein and/or one or more proteins discussed herein, and/or one or more of the following: corticosterone, D-Galactose, ethanolamine, glutathione, L-carnitine, linoleic acid, linolenic acid, progesterone, putrescine, sodium selenite, or triodo-I-thyronine, a B-27 ^® supplement, xeno-free B-27 ^® supplement, GS21™ supplement, an amino acid (such as arginine, cystine, isoleucine, leucine, lysine, methionine, glutamine, phenylalanine, threonine, tryptophan, histidine, tyrosine, or valine), monosaccharide, inorganic ion (such as sodium, potassium, calcium, magnesium, nitrogen, and/or phosphorus) or salts thereof, and/or molybdenum, vanadium, iron, zinc, selenium, copper, or manganese. In specific embodiments, one or more of these may be explicitly excluded.

[0244] The medium can also contain one or more externally added fatty acids or lipids, amino acids (such as non-essential amino acids), vitamin(s), growth factors, cytokines, antioxidant substances, 2-mercaptoethanol, pyruvic acid, buffering agents, and/or inorganic salts. . In specific embodiments, one or more of these may be explicitly excluded.

[0245] One or more of the medium components may be added at a concentration of at least, at most, or about 0.1, 0.5, 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 150, 180, 200, 250 ng/L, ng/ml, pg/ml, mg/ml, or any range derivable therein. [0246] In specific embodiments, the cells of the disclosure are specifically formulated. They may or may not be formulated as a cell suspension. In specific cases they are formulated in a single dose form. They may be formulated for systemic or local administration. In some cases the cells are formulated for storage prior to use, and the cell formulation may comprise one or more cryopreservation agents, such as DMSO (for example, in 5% DMSO). The cell formulation may comprise albumin, including human albumin, with a specific formulation comprising 2.5% human albumin. The cells may be formulated specifically for intravenous administration; for example, they are formulated for intravenous administration over less than one hour. In particular embodiments the cells are in a formulated cell suspension that is stable at room temperature for 1, 2, 3, or 4 hours or more from time of thawing.

[0247] In some embodiments, the method further comprises priming the T cells. In some embodiments, the T cells are primed with antigen presenting cells. In some embodiments, the antigen presenting cells present tumor antigens or peptides, such as those disclosed herein. [0248] In particular embodiments, the cells of the disclosure comprise an exogenous TCR, which may be of a defined antigen specificity. In some embodiments, the TCR can be selected based on absent or reduced alloreactivity to the intended recipient (examples include certain virus-specific TCRs, xeno-specific TCRs, or cancer-testis antigen-specific TCRs). In the example where the exogenous TCR is non-alloreactive, during T cell differentiation the exogenous TCR suppresses rearrangement and/or expression of endogenous TCR loci through a developmental process called allelic exclusion, resulting in T cells that express only the non- alloreactive exogenous TCR and are thus non-alloreactive. In some embodiments, the choice of exogenous TCR may not necessarily be defined based on lack of alloreactivity. In some embodiments, the endogenous TCR genes have been modified by genome editing so that they do not express a protein. Methods of gene editing such as methods using the CRISPR/Cas9 system are known in the art and described herein.

[0249] In some embodiments, the cells of the disclosure further comprise one or more chimeric antigen receptors (CARs). Examples of tumor cell antigens to which a CAR may be directed include at least 5T4, 8H9, a _v pe integrin, BCMA, B7-H3, B7-H6, CAIX, CA9, CD19, CD20, CD22, CD30, CD33, CD38, CD44, CD44v6, CD44v7/8, CD70, CD 123, CD 138, CD171, CEA, CSPG4, EGFR, EGFR family including ErbB2 (HER2), EGFRvIII, EGP2, EGP40, ERBB3, ERBB4, ErbB3/4, EPCAM, EphA2, EpCAM, folate receptor-a, FAP, FBP, fetal AchR, FRa, GD2, G250/CAIX, GD3, Glypican-3 (GPC3), Her2, IL-13Ra2, Lambda, Lewis- Y, Kappa, KDR, MAGE, MCSP, Mesothelin, Mucl, Mucl6, NCAM, NKG2D Ligands, NY-ESO-1, PRAME, PSC1, PSCA, PSMA, ROR1, SP17, Survivin, TAG72, TEMs, carcinoembryonic antigen, HMW-MAA, AFP, CA-125, ETA, Tyrosinase, MAGE, laminin receptor, HPV E6, E7, BING-4, Calcium-activated chloride channel 2, Cyclin-Bl, 9D7, EphA3, Tel om erase, SAP-1, BAGE family, CAGE family, GAGE family, MAGE family, SAGE family, XAGE family, NY-ESO-l/LAGE-1, PAME, SSX-2, Mel an- A/M ART - 1 , GP100/pmell7, TRP-1/-2, P. polypeptide, MC1R, Prostate-specific antigen, b-catenin, BRCAl/2, CML66, Fibronectin, MART-2, TGF-pRII, or VEGF receptors (e.g, VEGFR2), for example. The CAR may be a first, second, third, or more generation CAR. The CAR may be bispecific for any two nonidentical antigens, or it may be specific for more than two nonidentical antigens.

XI. Administration of Therapeutic Compositions

[0250] The therapy provided herein may comprise administration of a combination of therapeutic agents, such as a first cancer therapy and a second cancer therapy. The therapies may be administered in any suitable manner known in the art. For example, the first and second cancer treatment may be administered sequentially (at different times) or concurrently (at the same time). In some embodiments, the first and second cancer treatments are administered in a separate composition. In some embodiments, the first and second cancer treatments are in the same composition.

[0251] Embodiments of the disclosure relate to compositions and methods comprising therapeutic compositions. The different therapies may be administered in one composition or in more than one composition, such as 2 compositions, 3 compositions, or 4 compositions. Various combinations of the agents may be employed. [0252] The therapeutic agents of the disclosure may be administered by the same route of administration or by different routes of administration. In some embodiments, the cancer therapy is administered intravenously, intramuscularly, subcutaneously, topically, orally, transdermally, intraperitoneally, intraorbitally, by implantation, by inhalation, intrathecally, intraventricularly, or intranasally. In some embodiments, the antibiotic is administered intravenously, intramuscularly, subcutaneously, topically, orally, transdermally, intraperitoneally, intraorbitally, by implantation, by inhalation, intrathecally, intraventricularly, or intranasally. The appropriate dosage may be determined based on the type of disease to be treated, severity and course of the disease, the clinical condition of the individual, the individual's clinical history and response to the treatment, and the discretion of the attending physician.

[0253] The treatments may include various “unit doses.” Unit dose is defined as containing a predetermined-quantity of the therapeutic composition. The quantity to be administered, and the particular route and formulation, is within the skill of determination of those in the clinical arts. A unit dose need not be administered as a single injection but may comprise continuous infusion over a set period of time. In some embodiments, a unit dose comprises a single administrable dose.

[0254] The quantity to be administered, both according to number of treatments and unit dose, depends on the treatment effect desired. An effective dose is understood to refer to an amount necessary to achieve a particular effect. In the practice in certain embodiments, it is contemplated that doses in the range from 10 mg/kg to 200 mg/kg can affect the protective capability of these agents. Thus, it is contemplated that doses include doses of about 0.1, 0.5, 1, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, and 200, 300, 400,

500, 1000 pg/kg, mg/kg, pg/day, or mg/day or any range derivable therein. Furthermore, such doses can be administered at multiple times during a day, and/or on multiple days, weeks, or months.

[0255] In certain embodiments, the effective dose of the pharmaceutical composition is one which can provide a blood level of about 1 mM to 150 mM. In another embodiment, the effective dose provides a blood level of about 4 pM to 100 pM.; or about 1 pM to 100 pM; or about 1 pM to 50 pM; or about 1 pM to 40 pM; or about 1 pM to 30 pM; or about 1 pM to 20 pM; or about 1 pM to 10 pM; or about 10 pM to 150 pM; or about 10 pM to 100 pM; or about 10 pM to 50 pM; or about 25 pM to 150 pM; or about 25 pM to 100 pM; or about 25 pM to 50 pM; or about 50 pM to 150 pM; or about 50 pM to 100 pM (or any range derivable therein). In other embodiments, the dose can provide the following blood level of the agent that results from a therapeutic agent being administered to a subject: about, at least about, or at most about

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28,

29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53,

54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78,

79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100 mM or any range derivable therein. In certain embodiments, the therapeutic agent that is administered to a subject is metabolized in the body to a metabolized therapeutic agent, in which case the blood levels may refer to the amount of that agent. Alternatively, to the extent the therapeutic agent is not metabolized by a subject, the blood levels discussed herein may refer to the unmetabolized therapeutic agent.

[0256] Precise amounts of the therapeutic composition also depend on the judgment of the practitioner and are peculiar to each individual. Factors affecting dose include physical and clinical state of the patient, the route of administration, the intended goal of treatment (alleviation of symptoms versus cure) and the potency, stability and toxicity of the particular therapeutic substance or other therapies a subject may be undergoing.

[0257] It will be understood by those skilled in the art and made aware that dosage units of pg/kg or mg/kg of body weight can be converted and expressed in comparable concentration units of pg/ml or mM (blood levels), such as 4 pM to 100 pM. It is also understood that uptake is species and organ/tissue dependent. The applicable conversion factors and physiological assumptions to be made concerning uptake and concentration measurement are well-known and would permit those of skill in the art to convert one concentration measurement to another and make reasonable comparisons and conclusions regarding the doses, efficacies and results described herein.

XII. Kits

[0258] Certain aspects of the present invention also concern kits containing compositions of the disclosure or compositions to implement methods of the invention. In some embodiments, kits can be used to evaluate one or more biomarkers or HLA types. In certain embodiments, a kit contains, contains at least or contains at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,

16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40

41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 100, 500, 1,000 or more probes, primers or primer sets, synthetic molecules or inhibitors, or any value or range and combination derivable therein. [0259] Kits may comprise components, which may be individually packaged or placed in a container, such as a tube, bottle, vial, syringe, or other suitable container means.

[0260] Individual components may also be provided in a kit in concentrated amounts; in some embodiments, a component is provided individually in the same concentration as it would be in a solution with other components. Concentrations of components may be provided as lx, 2x, 5x, lOx, or 20x or more.

[0261] In certain aspects, negative and/or positive control nucleic acids, probes, and inhibitors are included in some kit embodiments. In addition, a kit may include a sample that is a negative or positive control for methylation of one or more biomarkers.

[0262] It is contemplated that any method or composition described herein can be implemented with respect to any other method or composition described herein and that different embodiments may be combined. The claims originally filed are contemplated to cover claims that are multiply dependent on any filed claim or combination of filed claims.

XIII. Sequences

[0263] E3 ubiquitin-protein ligase TRIM11 isoform X2 [Homo sapiens]; NCBI Reference Sequence: XP_016857901.1:

MAAPDL STNLQEEAT C AICLD YFTDP VMTDCGHNF CRECIRRCW GQPEGP Y ACPEC RELSPQRNLRPNRPL AKMAEM ARRLHPP SP VPQGV CP AHREPL AAF CGDELRLLC AA CERS GEHW AHRVRPLQD A AEDLK AKLEK SLEHLRKQMQD ALLF Q AQ ADET C VL W ODIKD ALRRY OD VKLOPPE VVPMELRT V CRVPGL VETLRRFRGD VTLDPDT ANPELI LSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALG V CRENVNRKEKGEL S AGNGF WIL VFLGS YYN S SERAL APLRDPPRRV GIFLD YEAGH LSF Y S ATDGSLLFIFPEIPF SGTLRPLF SPL S S SPTPMTICRPKGGSGDTL APQ (SEQ ID NO:l)

[0264] Peptide embodiments of the TRIM11 gene comprise: DETCVLWQD (SEQ ID NO: 7), VLWQDIKDAL (SEQ ID NO: 8), and LWQDIKDAL (SEQ ID NO: 9)

[0265] RCOR3 protein [Homo sapiens]; GenBank: AAH31608.1:

MPGMMEKGPELLGKNRS ANGS AKSP AGGGGSGAS STNGGLHY SEPESGC SSDDEHD VGMRVGAEY QARIPEFDPGATKYTDKDNGGMLVW SPYHSIPDARLDEYIAIAKEKH GYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRI QQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPM DGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMY LTQED WAV SC SPNAANTILRQLDMELISLKRQ VQNAKQVN S ALKQKMEGGIEEFKP PESNOKESi ARWTTEEOLL AVOGTDPT GS SDTGSIT SCPIIHSNTN SPY CHSEP ASTTS S S NTACCPGSSPAASSTPAAGSVHPAPANFKSASTTSYSPC (SEQ ID NO:2)

[0266] Peptide embodiments of the RCOR3 gene comprise: LAVQGTDPT (SEQ ID NO: 10). [0267] Protein FAM76B isoform 1 [Homo sapiens]; NCBI Reference Sequence: NP_653265.3:

MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTIC K KCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQTCEQCKQQCAFDRK EEGRRKVDGKLLCWLCTLS YKRVLQKTKEQRKSLGS SHSNSSS S SLTEKDQHHPKH HHHHHHHHHRHS S SHHKI SNL SPEEEQGLWKQ SHK S S ATIQNETPKKKPKLE SKP SN GDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQY QESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSILTSP (SEQ ID NO:3)

[0268] Peptide embodiments of the FAM76B gene comprise: PSNGDSSSI (SEQ ID NO: 11) and KPSNGDSSSI (SEQ ID NO: 12)

[0269] Sarcolemmal membrane-associated protein isoform f [Homo sapiens]; NCBI Reference Sequence: NP_001298107.1:

MDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFEL Q ALLEEERK A YRN Q VEE S TKQIQ VLQ AQLQRLHIDTENLREEKD SEIT S TRDELL S AR DEILLLHQ AAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQN SF QL RCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELH N S QKQ SLELT SDL SILQM SRKELENQ VGSLKEQHLRD S ADLKTLL SK AEN Q AKD V QK EYEKTQTVL SELKLKFEMTEQEKQ SITDELKQCKNNLKLLREKGNNP SILQPVP AVFI GLFLAFLFWCFGPLW (SEQ ID NO:4)

[0270] Peptide embodiments of the SLMAP gene comprise: NNPSILQPV (SEQ ID NO: 13), REKGNNPSI (SEQ ID NO: 14), and REKGNNPSIL (SEQ ID NO: 15)

[0271] Transmembrane protein 62 isoform a [Homo sapiens]; NCBI Reference Sequence: P_079232.3:

[0272] M A A VL ALRV V AGL A A A AL V AMLLEH Y GL AGQP SPLPRP APPRRPHP APGP GD SNIF W GLQISDIHL SRFRDPGRAVDLEKF C SETIDIIQP AL VL AT GDLTD AKTKEQL GSRQHEVEWQT Y QGILKKTRVMEKTKWLDIKGNHD AFNIP SLD SIKNYYRK Y S AVR RDGSFHYVHSTPF GNY SFIC VD ATVNPGPKRPYNFF GILDKKKMEELLLLAKES SRSN HTIWFGHFTTSTILSPSPGIRSIMSSAIAYLCGHLHTLGGLMPVLHTRHFQGTLELEVG D WKDNRRYRIF AFDHDLF SF ADLIF GKWP V VLITNPK SLL Y S CGEHEPLERLLHS THI RVL AF SL S SIT S VT VKIDGVHLGQ AVHVSGPIF VLKWNPRNY S SGTHNIE VI VQD S AG RSKSVHHIFSVQENNHLSFDPLASFILRTDHYIMARVLFVLIVLSQLTILIIFRYRGYPE LKEP SGFINLTSF SLHVL SKINIF YY SVLLLTL YTVEGPWFF GEIIDGKF GCCF SF GIF VN GHFLQGSITFIIGILQLAFFNIPLM AYMCW SLLQRCF GHNFRSHLHQRK YLKIMPVHL LMLLL YIW Q V Y S C YFL Y AT Y GTL AFLF SPLRTWLTLLTP VLIR Y VWTLN S TKF GIFM VQLKSHLSS (SEQ ID NO:5)

[0273] Peptide embodiments of the TMEM62 gene comprise: YTVEGPWFF (SEQ ID NO: 16), TLYTVLGPW (SEQ ID NO: 17), TLYTVLGPWF (SEQ ID NO: 18), LYTVLGPWF (SEQ ID NO: 19), LTLYTVLGPW (SEQ ID NO:20), LYTVLGPWFF (SEQ ID NO:21), and VLGPWFFGEI (SEQ ID NO:22).

[0274] PLA2G6 [Homo sapiens]; GenBank: CAG30429.1 :

MQFFGRLVNTF SGVTNLF SNPFRVKEVAVAD YTS SDRVREEGQLILF QNTPNRTWDC VLVNPRNSQSGFRLF QLELEADALVNFHQ Y S SQLLPF YES SPQVLHTEVLQHLTDLIR NHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLA CQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDP RY GASPLHWAKNAEMARMLLKRGCNVNSTS S AGNTALHVAVMRNRFDC AIVLLTH GANAD ARGEHGNTPLHL AMSKDNVEMIKALIVF GAEVDTPNDF GETPTFL ASKIGRL VTRKAILTLLRTVGAEY CFPPIHGVPAEQGS AAPHHPF SLERAQPPPISLNNLELQDLM HISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFD W V AGT S T GGIL AL AILHSK SM A YMRGM YFRMKDE VFRGSRP YE SGPLEEFLKREF G EHTKMTD VRKPK VMLT GTL SDRQP AELHLFRN YD APET VREPRFN QNVNLRPP AQP SDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQA NKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTD PDGRAVDRARAW CEM V GIQ YFRLNPQLGTDIMLDE V SDT VLVNALWETE VYIYEHR EEF QKLIQLLL SP (SEQ ID NO:6)

[0275] Peptide embodiments of the TMEM62 gene comprise: TFLASKIGRLV (SEQ ID NO:23), RLVTRKAIL (SEQ ID NO:24), FLASKIGRL (SEQ ID NO:25), SKIGRLVTRK (SEQ ID NO:26), FLASKIGRL V (SEQ ID NO:27), LASKIGRLV (SEQ ID NO:28), and KIGRLVTRK (SEQ ID NO:29).

[0276] TRA and TRB CDR3 sequences include those listed below: TRA-1 CDR3: C A VHEIQ GAQKL VF (SEQ ID NO:30); TRB-1 CDR3: CASSFGVSYEQYF (SEQ ID NO:31); TRA-2 CDR3: CAMRPLGGYNKLIF (SEQ ID NO:32); TRB -2 CDR3: CASSQAANEQFF (SEQ ID NO:33); TRA- 3 CDR3: C AEEGDRD YKL SF (SEQ ID NO:34); TRB-3 CDR3: CASTGRSGRSEQYF (SEQ ID NO:35); TRA-4 CDR3: CAFMKGRDDKIIF (SEQ ID NO:36); TRB-4 CDR3: CATTLPGDTEAFF (SEQ ID NO:37); TRA-5 CDR3: CATANNAGNMLTF(SEQ ID NO:38); TRB-5 CDR3: CAS SLDRHQPQHF (SEQ ID NO:39); TRA-6 CDR3: CALWEGQGGSEKLVF (SEQ ID NO:40); TRB-6 CDR3: CASSLEARAPSGNTIYF (SEQ ID N0:41); and TRA-7 CDR3: C AV GAGT GT ASKLTF (SEQ ID NO:42); TRB-7 CDR3: CASSLELAGGRDTQYF (SEQ ID NO:43).

[0277] Additional peptide embodiments include those below:

XIV. Examples

[0278] The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1: Tumor antigens arising from alternative splicing events may be targetable by Tumor infiltrating lymphocytes in glioblastomas

[0279] Alternative splicing, the cellular process that converts premature mRNA to mature mRNA and allows for a single gene to produce multiple protein products, is frequently dysregulated in many cancers, including glioblastoma. However, along with non-synonymous mutations in the DNA, altered splicing mechanisms in cancers may produce novel tumor antigens that distinguish cancer cells from healthy cells and can thus be targeted by the immune system.

[0280] Provided in FIG. 3 is an exemplary computational pipeline to identify antigenic peptides from RNA data of neoplastic tissue. The computational pipeline, referred to Isoform peptides from RNA splicing for Immunotherapy target Screening (IRIS), is an integrated package. As can be seen, the process has three major modules: (1) processing of RNA-Seq data, (2) in silico screening of splice isoforms, and (3) integrated prediction of TCR/CAR-T targets.

[0281] The inventors used the IRIS (Isoform peptides from RNA splicing for Immunotherapy targets Screening) platform to take bulk RNA-sequencing data from 23 glioblastoma patient tumor samples and predict tumor antigens that may arise from alternative splicing events. Predicted tumor antigens that arose in HLA*A02:01 and HLA*A03:01 patients were prioritized and 8 potential tumor antigens were selected to generate peptide:MHC Class 1 dextramers. The inventors tested PBMCs and/or ex vivo expanded tumor infiltrating lymphocytes (TIL) from 6 glioblastoma patients against these dextramers, sorted for any tumor antigen-reactive T cells, and performed single-cell RNA sequencing on the sorted population to determine the TCR sequence.

[0282] Among the 8 predicted tumor antigens tested, 7 of the tumor antigens were recognized by at least 1 patient’s T cells. 1 HLA*A03:01 epitope was recognized in 3 of the 4 HLA*A03:01 patients and this epitope was highly positive in one of those patients’ expanded TIL population, representing 1.7% of all CD3+ CD8+ cells. When the inventors sorted for those tumor antigens reactive T cells from the expanded TIL population and performed single cell RNA sequencing, they found 325 unique T cell clonotypes, but the top 10 clonotypes represented 83.6% of all clonotypes, with the most frequent clonotype representing 39.1% of all clonotypes and indicating clonal expansion of a select few TCR clones from within the tumor.

[0283] In total, the data indicates that tumor antigens arising from alternative splicing events may represent a potential target for immunotherapy in glioblastoma.

Example 2: IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

[0284] Cancer immunotherapy has gained tremendous momentum in the past decade. The clinical effectiveness of checkpoint inhibitors, such as neutralizing antibodies against PD- 1 and CTLA-4, is thought to result from their ability to reactivate tumor-specific T cells (1). Meanwhile, adoptive cell therapies use genetically modified T-cell receptors (TCRs) or synthetic chimeric antigen receptor T cells (CAR-T) for tumor-specific antigen recognition (2). The finding that cancer cells express specific T-cell-reactive antigens has galvanized epitope discovery in recent years (3-6). Nevertheless, the identification of tumor antigens remains a major challenge (7,8). Although somatic mutation-derived antigens have been successfully targeted by cancer therapies (9-12), this approach remains largely ineffective for tumors with low or moderate mutation loads (7-13).

[0285] Various types of dysregulation at the RNA level can generate immunogenic peptides in cancer cells (13-15). Notably, tumors harbor up to 30% more alternative splicing (AS) events than normal tissues, and the resulting peptides are predicted to be presented by human leukocyte antigen (HLA) (16). However, there are no integrated methods to systematically identify AS-derived tumor antigens. Therefore, the inventors leveraged tens of thousands of normal and tumor transcriptomes generated by large-scale consortium studies (e.g. GTEx, TCGA) (17,18) to build a versatile, big data-informed platform for discovering AS-derived immunotherapy targets. This in silico platform, named ‘IRIS’ (Isoform peptides from RNA splicing for Immunotherapy target Screening), incorporates three main components: processing of RNA-Seq data, in silico screening of tumor AS isoforms, and integrated prediction and prioritization of TCR and CAR-T targets (FIG. 3).

[0286] IRIS’s RNA-Seq data-processing module uses standard input data to discover and quantify AS events in tumors using the ultra-fast rMATS-turbo software (19,20). Identified AS events are fed to the in silico screening module, which statistically compares AS events against any combination of events selected from large-scale (>10,000) reference RNA-Seq samples of normal and tumor tissues (FIG. 6) to identify AS events that are tumor-associated, tumor- recurrent, and potentially tumor-specific (Methods). Tumor specificity is a key metric for evaluating potential tissue toxicity, which is an important side effect of targeting lineage- specific antigens that are expressed by both tumor and normal cells (21). In addition to screening multiple patient samples simultaneously in the default ‘group mode’, IRIS can be performed in the ‘personalized mode’ to identify targets for a specific patient sample (Methods). Potential false-positive events are removed by using a blacklist of AS events whose quantification across diverse RNA-Seq datasets is error-prone due to technical variances such as read length (Methods and FIG. 7). IRIS’s target prediction module first constructs splice- junction peptides of predicted tumor isoforms and then predicts AS-derived targets for TCR/CAR-T therapies (Methods). This module performs tumor HLA typing using RNA-Seq data and then integrates multiple HLA-binding prediction algorithms for predicting TCR targets and/or peptide vaccines. In parallel, protein extracellular domain annotations are used for predicting CAR-T targets (FIG. 8). IRIS also includes the option to confirm predicted AS- derived targets using mass spectrometry (MS) data via proteo-transcriptomics data integration. This option provides an orthogonal approach for target discovery and validation by integrating RNA-Seq data with various types of MS data, such as whole-cell proteomics, surfaceomics, or immunopeptidomics data (Methods and FIG. 9A).

[0287] The inventors performed a proof-of-concept analysis and preliminary confirmation of AS-derived epitopes by applying IRIS to RNA-Seq and MS-based immunopeptidomics data of cancer and normal cell lines. The inventors identified hundreds of AS-derived epitopes that were supported by both RNA-Seq and MS data (FIG. 9B, Table 1). MS-supported epitopes were enriched for transcripts with high expression levels and peptides with strong predicted HLA-binding affinities (FIG. 9C-E), consistent with the expected pattern of HLA-epitope binding (22).

[0288] To explore IRIS’ s ability to discover AS-derived immunotherapy targets in clinical samples, the inventors generated RNA-Seq data from 22 resected glioblastomas (GBMs) and analyzed these data by IRIS. Candidate epitopes were then validated based on their recognition by patient T cells. FIG. 4 (top) summarizes the stepwise IRIS results. After uniform processing of RNA-Seq data by rMATS-turbo, IRIS discovered 190,232 putative skipped exon (SE) events from the 22 GBM samples. Using the in silico screening module, the inventors compared these AS events against reference normal and tumor panels to evaluate tumor association, recurrence, and specificity (Methods). Specifically, AS events were compared against: normal brain samples from GTEx (tissue-matched normal panel, for evaluating tumor association), two cohorts of brain tumor samples - GBM and lower-grade glioma (LGG) - from TCGA (tumor panel, for evaluating tumor recurrence), and 11 other selected normal (nonbrain) tissues from GTEx (normal panel, for evaluating tumor specificity). After initially screening against the tissue-matched normal panel and removing blacklisted events, IRIS identified 6,276 tumor-associated AS events in the 22 GBM samples (‘Primary’ set, FIG. 4). Of these, 1,738 events were identified as tumor-recurrent and tumor-specific based on comparison with the tumor panel and normal panel, respectively (‘Prioritized’ set, FIG. 4; Table 2).

[0289] Next, for each AS event, splice junctions of the tumor isoform (i.e. the isoform that was more abundant in the tumor samples than in the tissue-matched normal panel) were translated into peptides, followed by TCR/CAR-T target prediction (FIG. 4). For the GBM dataset, IRIS predicted 4,153 ‘primary’ tumor-associated epitope-producing splice junctions. Of these, 1,127 were tumor-recurrent and tumor-specific compared to the tumor panel and normal panel, respectively, and were predicted to be ‘prioritized’ TCR targets. In parallel, IRIS identified 416 ‘primary’ tumor-associated extracellular peptide-producing splice junctions, of which 87 were predicted to be ‘prioritized’ CAR-T targets.

[0290] IRIS generates an integrative report for predicted immunotherapy targets (Table 3). Representative examples for six prioritized TCR targets are shown in the bottom panel of FIG. 4 (see FIG. 8B for CAR-T target examples). Violin plots depict exon inclusion levels across the 22 GBM samples (‘GBM-input’) and different sets of reference panels using the percent- spliced-in (PSI) metric (23). Tumor isoforms can be either the exon-skipped (low PSI) or the exon-included (high PSI) isoform compared to the tissue-matched normal panel. As illustrated by the darker dots in the ‘Summary’ column, all six epitope-producing splice junctions were tumor-associated compared to the tissue-matched normal panel (‘Brain’), and tumor-recurrent compared to the tumor panel (‘GBM’ and ‘LGG’). Two AS events (in TRIM11 and FAM76B) consistently showed distinct PSI values in tumors compared to normal brain and nonbrain tissues, indicating high tumor specificity. For candidate splice junctions, IRIS also calculates the fold-change (FC) of tumor isoforms between tumor samples and the tissue-matched normal panel (Methods). For example, the tumor isoform in TRIM 11 had an average isoform proportion of 8.60% in the 22 GBM samples and 0.13% in normal brain samples, representing an FC of 65.6 in tumor samples versus the tissue-matched normal panel. The inventors note that, as shown under ‘Predicted HLA-epitope binding’, a single splice junction can give rise to multiple putative epitopes with distinct peptide sequences and HLA binding affinities.

[0291] Finally, the inventors sought to validate the immunogenicity and T-cell recognition of IRIS-identified candidate TCR targets using an MHC class I dextramer-based assay (12,24). The inventors focused on predicted AS-derived tumor epitopes with strong putative HLA- binding affinity to common HLA types found in at least five of the 22 patients. The inventors selected seven AS-derived tumor-associated epitopes (five HLA-A02:01 and two HLA- A03:01) for dextramer-based T-cell recognition testing (Table 4). All but one epitope (YAIVWVNGV (SEQ ID NO: 62)) showed some degree of tumor specificity when evaluated in normal (nonbrain) tissues (‘vs. Normal’, see FIG. 5A). The inventors obtained customized HLA-matched, fluorescently labeled MHC class I dextramenpeptide (pMHC) complexes for each candidate epitope. The inventors conducted flow cytometry to detect CD8 ⁺ T-cell binding with the pMHC complexes using available peripheral blood mononuclear cells (PBMCs) and/or ex v/vo-expanded tumor-infiltrating lymphocytes (TILs). Based on the binding of each AS-derived tumor epitope to a patient’s CD3 ⁺ CD8 ⁺ T cells, the inventors classified epitope reactivity as ‘positive’ (binding > 0.1% of cells), ‘marginal’ (binding 0.01-0.1% of cells), or ‘negative’ (binding < 0.01% of cells). Epitopes that showed at least marginal reactivity were considered to be ‘recognized’ by patient T cells. The inventors analyzed samples from two HLA-A02:01 and four HLA-A03:01 patients, as well as samples from three HLA-A02:01 and three HLA-A03:01 healthy donors (Table 5, Supplementary Data).

[0292] Both predicted HLA-A03:01 tumor epitopes were recognized by patient T cells. In particular, one epitope (KIGRLVTRK (SEQ ID NO:29), in PLA2G6) was recognized by T cells from all four tested patients but only one of the three tested healthy donors. In one patient (LB2867), recognition of tumor epitope KIGRLVTRK (SEQ ID NO: 29) was marginal in PBMCs but positive in the expanded TIL population, with epitope-reactive T cells representing 0.03% of T cells in PBMCs and 1.69% of T cells in TILs. This patient had been previously treated with neoadjuvant anti-PD-1 and anti-CTLA-4 checkpoint blockade immunotherapy. These results suggest epitope KIGRLVTRK (SEQ ID NO:29) as a promising immunotherapy target in HLA-A03 patients from the GBM cohort. T cells from another patient (LB2907) showed positive reactivity to both tested HLA-A03:01 epitopes. All four predicted HLA- A02:01 epitopes were recognized by T cells from tested patients and healthy donors. The non- tumor-specific epitope (YAIVWVNGV (SEQ ID NO:62), bottom row in FIG. 5A) was tested in two patients and three healthy donors and was recognized by T cells in only one healthy donor (marginal reactivity, 0.013% of CD3 ⁺ CD8 ⁺ T cells). Taken together, the dextramer- based assay results indicate that the AS-derived TCR targets predicted by IRIS can be recognized by tumor-infiltrating and peripheral CD3 ⁺ CD8 ⁺ T cells.

[0293] Dextramer-positive T cells are expected to contain many clonotypes, only a few of which are dominant. To discover and quantify which TCR clonotypes comprise the epitope- reactive T cells, the inventors sorted the TILs from one patient (LB2867) for cells that reacted positively with the KIGRLVTRK (SEQ ID NO:29) pMHC complex (FIG. 5B), and performed V(D)J immune profiling using single-cell RNA-Seq (scRNA-Seq) on the sorted population (FIG. 5C). Of the 325 unique TCR clonotypes, the 10 most abundant TCRs represented 86.3% of all clonotypes (Table 6), with the most frequent clonotype comprising 38.9% of all epitope- reactive T cells. This result suggests that there was clonal expansion of a select few dominant TCR clones within the tumor that were able to recognize the AS-derived epitope. To further validate the inventors’ findings using complementary approaches, the inventors analyzed bulk expanded TILs using immunoSEQ and pairSEQ assays (FIG. 5C, FIG. 10). The inventors confirmed that the top 10 reported clonotypes from scRNA-Seq were present in the bulk TIL population based on the TCR b-chain CDR3 region. In addition, the pairSEQ assay, which uses statistical modeling to predict pairing of TCR a and b chains, found identically paired TCRs for seven of the top 10 TCRs from scRNA-Seq. Together, these data suggest that a select few TCR clones dominantly recognize the AS-derived epitope KIGRLVTRK (SEQ ID NO:29) in this patient.

[0294] In summary, the inventors have developed IRIS, a big data-powered platform for discovering AS-derived tumor antigens as an under exploited source of immunotherapy targets. Using IRIS followed by a dextramer-based assay, the inventors discovered and validated AS- derived tumor epitopes recognized by T cells in patients. These results provide experimental evidence for the immunogenicity of tumor antigens arising from AS and reveal novel potential targets for TCR and CAR-T therapies.

1. Methods

[0295] IRIS module for RNA-Seq data processing. IRIS accepts standard formats of raw RNA-Seq FASTQ files and/or tab-delimited files of quantified AS events (from rMATS-turbo) as input data (FIG. 3). For raw RNA-Seq data, IRIS provides a standalone pipeline that aligns RNA-Seq reads to the reference human genome hgl9 using the STAR 2.5.3a (25) two-pass mode, followed by Cufflinks v2.2.1 (26) and rMATS v4.0.2 (rMATS-turbo) (19,20) for quantification of gene expression and AS events, respectively, based on the GENCODE (V26) (27) gene annotation. To quantify AS events, the inventors converted splice-junction counts in rMATS-turbo output into PSI (23) values. For each dataset, the inventors removed low- coverage AS events, defined as events with an average count of less than 10 reads for the sum of all splice junctions across all samples in that dataset (tissue/tumor type). The inventors applied this procedure to the 22 GBM samples from the UCLA cohort (BioProject: PRJNA577155), as well as to the normal and tumor samples of the reference panels used by IRIS. For the GTEx normal samples, aligned BAM files downloaded from the dbGAP repository were used directly for AS quantification.

[0296] Constructing big-data reference panels of AS events across normal human tissues and tumor samples. IRIS’ s big-data reference panels of normal and tumor samples are available as pre-processed, pre-indexed databases for fast retrieval by the IRIS program (FIG. 6). Specifically, 9,662 normal samples from the GTEx project (V7) (17) representing 53 tissue types of 30 histological sites were uniformly processed as described above. As shown in FIG. 6, exon-based quantification of AS events was able to distinguish samples by tissue type. Selected TCGA (16,28) tumor samples (FIG. 6C) were processed similarly to form the tumor panel. Additionally, IRIS provides a stand-alone indexing function for users to include custom normal and tumor samples in their reference panels.

[0297] IRIS module for in silico screening of tumor AS events. IRIS performs in silico screening using two-sided and one-sided /-tests to identify tumor-associated, tumor-recurrent, and tumor-specific AS events in group comparisons. To define an AS event as significantly different from a reference group (i.e., to identify tumor-associated/tumor-specific events), IRIS sets two requirements: 1) a significant p-value from the two-sided /-test (default: p < 0.01), and 2) a threshold of PSI value difference (default: abs(A\|/) > 0.05). With a slight modification, to define an AS event as recurrent in a reference group (tumor-recurrent events), IRIS compares a tumor reference group with the tissue-matched normal panel and requires: 1) a significant p- value from the one-sided /-test in the same direction as the corresponding ‘tumor-associated’ event (default: p < 0.01/number of ‘tumor-associated’ events [Bonferroni correction due to large sample sizes in reference panels]), and 2) a threshold of PSI value difference (default: abs(A\ _|/ ) > 0.05). In addition, a threshold of the number of significant comparisons against groups in the normal or tumor reference panel is used to determine whether AS-derived antigens are tumor-specific or tumor-recurrent. For each AS event, IRIS defines the ‘tumor isoform’ as the isoform that is more abundant in tumors than in the tissue-matched normal panel. Optionally, to rank or filter targets, IRIS estimates the ‘fold-change (FC) of tumor isoform’ as the FC of the tumor isoform’ s proportion in tumors compared to the tissue-matched normal panel. In addition to the default ‘group mode’, IRIS can be used to screen targets for a specific patient sample through the ‘personalized mode’. This mode uses an outlier detection approach, combining a modified Tukey’s rule (29) and a user-defined threshold of PSI value difference.

[0298] Identification of AS events that are prone to measurement errors due to technical variances across big-data reference panels. IRIS’ s big-data reference panels were constructed by integrating various large-scale datasets with distinct technical conditions, such as RNA-Seq read length (30). Such technical variances across datasets could introduce discrepancies in the quantification of AS events (30). To identify error-prone AS events, the inventors employed a data-based heuristic strategy to assess the effects of RNA-Seq read length (48 bp vs. 76 bp) and aligner (STAR vs. Tophat) on AS quantification (PSI value) (FIG. 7A). For a given tissue type (in this study, brain tissue), 10 randomly selected 76-bp RNA-Seq files from GTEx were artificially trimmed to 48 bp, and both 76- and 48-bp RNA-Seq files were aligned with STAR2.5.3a. Corresponding Tophat (v.l.4.1)-aligned 76-bp BAM files were directly downloaded from GTEx. AS events were quantified by rMATS-turbo. Events with significantly different PSI values (p < 0.05, abs(A\ _|/ ) > 0.05 from paired /-test) among RNA- Seq datasets with distinct technical conditions were included in a blacklist. Results of this analysis for GTEx normal brain samples are shown in FIG. 7B.

[0299] IRIS module for predicting AS-derived TCR and CAR-T targets. To obtain protein sequences of AS-derived tumor isoforms, IRIS generates peptides by translating splice- junction sequences into amino-acid sequences using known ORFs from the UniProtKB (31) database. Within each AS event, the splice-junction peptide sequence for the tumor isoform is compared to that of the alternative normal isoform, to ensure that the tumor isoform splice junction produces a distinct peptide.

[0300] For TCR target prediction, IRIS employs seq2HLA (32), which uses RNA-Seq data to characterize HLA class I alleles for each tumor sample. IRIS then uses IEDB API (33) predictors to obtain the putative HLA binding affinities of candidate epitopes. The IEDB ‘recommended’ mode runs several prediction tools to generate multiple predictions of binding affinity, which IRIS summarizes as a median ICso value. By default, a threshold of median(IC5o) < 500 nM denotes a positive prediction for an AS-derived TCR target.

[0301] For CAR-T target prediction, IRIS maps AS-derived tumor isoforms to known protein extracellular domains (ECDs), as potential candidates for CAR-T therapy (FIG. 8A). Specifically, IRIS generates pre-computed annotations of protein ECDs. First, protein cellular localization information was retrieved from the UniProtKB (31) database (flat file downloaded in April 2018). ECD information was retrieved by searching for the term ‘extracellular’ in topological annotation fields, including ‘TOPO DOM’, ‘TRANSMEM’, and ‘REGION’, in the flat file. Second, BLAST (34) was used to map individual exons in the gene annotation (GENCODE V26) to proteins with topological annotations. Third, the BLAST result was parsed to create annotations of the mapping between exons and ECDs in proteins. These pre computed annotations are queried to search for AS-derived peptides that can be mapped to protein ECDs as potential CAR-T targets.

[0302] Proteo-transcriptomics data integration for MS validation. IRIS includes an optional proteo-transcriptomics data integration function that incorporates various types of MS data, such as whole-cell proteomics, surfaceomics, or immunopeptidomics data, to validate RNA-Seq-based target discovery at the protein level (FIG. 9A). Specifically, sequences of AS- derived peptides are added to canonical and isoform sequences of the reference human proteome (downloaded from UniProtKB in September 2018). For immunopeptidomics data, fragment MS spectra are searched against the RNA-Seq-based custom proteome library with no enzyme specificity using MSGF+ ³⁵ . The search length is limited to 7-15 amino acids. The target-decoy approach is employed to control the false discovery rate (FDR) or ‘QValue’ at 5%.

[0303] IRIS analysis of immunopeptidomics data. Published matching RNA-Seq and MS immunopeptidomics data of B-LCL-S1 and B-LCL-S2 cell lines (B lymphoblastoid cell lines from two individual donors) were retrieved from Laumont et al. (36) (GEO: GSM1641206, GSM1641207, and PRIDE: PXD001898). Raw RNA-Seq data of the JeKo-1 lymphoma cell line were obtained from the Cancer Cell Line Encyclopedia via the NCI Genomic Data Commons (available online at portal.gdc.cancer.gov/legacy-archive/). Corresponding immunopeptidomics MS data of JeKo-1 were retrieved from Khodadoust et al. ³¹ (PRIDE: PXD004746).

[0304] RNA-Seq data of the normal (B-LCL-S1, B-LCL-S2) and cancer (JeKo-1) cell lines were analyzed by IRIS as described above, with minor modifications. Specifically, AS events identified by the IRIS RNA-Seq data processing module were not subjected to the in silico screening module, but instead were directly used for the MS search. For MSGF+, FDR was set at 5%, which had the best concordance with predicted binding affinities (FIG. 9C-D). For comparison of predicted HLA binding and nonbinding peptides (FIG. 9D), a set of nonbinding peptides was created by randomly selecting peptides with median(IC5o) > 500 nM to the same number of binding peptides (median(IC5o) < 500 nM).

[0305] IRIS discovery of candidate TCR and CAR-T targets from 22 GBM samples.

RNA-Seq samples were processed by IRIS. Detected skipped exon (SE) events were analyzed by using the IRIS screening and target prediction modules with the aforementioned default parameters. For reference panels, the ‘tissue-matched normal panel’ comprised normal brain tissue samples from GTEx; the ‘normal panel’ comprised other normal (nonbrain) tissue samples of 11 selected vital tissues (heart, skin, blood, lung, liver, nerve, muscle, spleen, thyroid, kidney and stomach) from GTEx; and the ‘tumor panel’ comprised two cohorts of brain tumor samples (GBM and LGG) from TCGA. The blacklist of AS events created for brain was applied before in silico screening by IRIS to eliminate error-prone AS events (FIG.

7)·

[0306] In screening for the ‘Primary’ set of AS events, the inventors considered an event to be ‘tumor-associated’ if it was significantly different from the tissue-matched normal panel, using the default criteria described in ‘IRIS module for in silico screening of tumor AS events’. In screening for the ‘Prioritized’ set, the inventors prioritized an AS event if it was both ‘tumor- recurrent’ (significantly similar to at least 1 of 2 groups in the GBM/LGG tumor panel) and ‘tumor-specific’ (significantly different from multiple of 11 groups in the normal panel in the same direction as the tissue-matched normal panel. Here, the inventors used at least 2 groups to allow detection of AS events distinct from multiple groups in the normal panel).

[0307] When selecting potential TCR targets for dextramer validation, the inventors applied three additional criteria: 1) predicted median(IC5o) < 300 nM; 2) predicted binding to common HLA types, including HLA-A02:01 and HLA-A03:01; and 3) predicted binding to at least five patients in the GBM cohort. After excluding targets with low gene expression (average FPKM < 5), the inventors selected seven epitopes to test for T-cell recognition by dextramer assays. [0308] Patients. Tumor specimens were collected from 22 consenting patients with GBM who underwent surgical resection for tumor removal at the University of California, Los Angeles (UCLA; Los Angeles, CA). From these patients, the inventors also obtained PBMCs and TILs from two HLA-A02:01+ and four HLA-A03:01+ patients. All patients provided written informed consent, and this study was conducted in accordance with established Institutional Review Board-approved protocols.

[0309] PBMC collection. Peripheral blood was drawn from patients before surgery and diluted 1:1 in RPMI media (Thermo Fisher Scientific, cat. no. MT10041CV). PBMCs, extracted by Ficoll gradient (Thermo Fisher Scientific, cat. no. 45-001-750), were washed twice in RPMI media. Collected PBMCs were frozen in 90% human AB serum (Thermo Fisher Scientific, cat. no. MT35060CI) and 10% DMSO (Sigma, cat. no. C6295-50ML) and stored in liquid nitrogen. In parallel, PBMCs from healthy HLA-A02:01 and HLA-A03:01 donors were purchased from Bloodworks Northwest (Seattle, WA) or Astarte Biologies (Bothell, WA). [0310] TIL collection. Surgically resected tumor samples were digested with a brain tumor dissociation kit (Miltenyi Biotec, cat. no. 130-095-42) and gentle MACS dissociator (cat. no. 130-093-235). After digestion and myelin depletion, collected cells were labeled with CD45 microbeads (cat. no. 130-045-801) and separated on Miltenyi LS columns (cat. no. 130-042- 401) and MidiMACS Separator (cat no. 130-042-302). Collected CD45 ⁺ cells were cultured at UIO ⁶ cells/mL in X-VIVO 15 Media (Fisher Scientific, cat. no. BW04-418Q) containing 2% human AB serum with 50 ng/mL anti-CD3 antibody (BioLegend, cat. no. 317304), 1 pg/mL anti-CD28 antibody (BD Biosciences, cat. no. 555725), 1 pg/mL anti-CD49d antibody (BD Biosciences, cat. no. 555501), 300 IU/mL IL-2 (NIH, cat. no. 11697), and 10 ng/mL IL-15 (BioLegend, cat. no. 570302). Cells were expanded for 3-4 weeks and replenished with fresh media and cytokines every 2-3 days. Before freezing, expanded cells were placed in media containing 50 IU/mL IL-2 for 1-2 days and then frozen in the same freezing media as PBMCs. [0311] Collection of tumor RNAs and RNA sequencing. RNA from freshly collected or flash-frozen tumor specimens was extracted by using the RNeasy Mini Kit (Qiagen, cat. no. 74014). Paired-end RNA-Seq was performed at the UCLA Clinical Microarray Core using an Illumina HiSeq 3000 at a read length of 2x100 bp or 2x150 bp.

[0312] Dextramer flow-cytometric analysis of PBMCs and TILs. For each AS-derived peptide selected for validation, custom-made HLA-matched MHC Class I dextramenpeptide (pMHC) complexes were purchased from Immudex (Copenhagen, Denmark). Immudex also provided pMHC complexes for common cytomegalovirus (CMV) epitopes (cat. nos. WB2132 and WC2197) and for a nonhuman epitope (NI3233) as a negative control. Each pMHC complex was purchased with two separate tags for APC or PE fluorescence labeling, to increase specificity to targeted T cells with dual labeling.

[0313] To facilitate proper gating of CD8 ⁺ T cells from PBMC and TIL populations, the following panel of antibodies (from BioLegend) was set up: CD3 BV605 (cat. no. 300460), CD8 FITC (cat. no. 344704), CD4 BV421 (cat. no. 317434), CD19 BV421 (cat. no. 302234), CD56 BV421 (cat. no. 362552), and CD14 BV421 (cat. no. 301828). For single-color compensation controls, OneComp eBeads were used (Thermo Fisher Scientific, cat. no. 01- 1111-41).

[0314] For each set of pMHC complexes, at least 3xl0 ⁶ cells were stained according to manufacturer’s guidelines. Briefly, cells were thawed in a 37°C water bath and washed with RPMI and D-PBS (Fisher Scientific, cat. no. MT21031CV) before staining for cell viability with the Zombie Violet Viability Kit (BioLegend, cat. no. 423113). Next, the appropriate amount of each pMHC complex in a staining buffer of D-PBS with 5% fetal bovine serum (Fisher Scientific, cat. no. MT35016CV) was added to each sample. After 10 min, the aforementioned antibody cocktail was added. After a 30-min incubation period, cells were washed twice in the same staining buffer. All samples were tested in a BD LSRII flow cytometer, and data were analyzed with FlowJo (Treestar). For gating, the lymphocyte population was first selected using forward and side scatter, and then the BV421 -negative population was gated out (i.e. excluding dead cells and the CD14, CD19, CD56, and CD4 populations) before selecting the CD3 ⁺ CD8 ⁺ population. To set for proper gating of dextramer- positive cells, the inventors used cells that were stained with the full antibody panel but no pMHC complexes, and cells that were given the nonhuman pMHC complex.

[0315] TCR sequencing using scRNA-Seq. Cells were stained by following the dextramer procedure with PE-conjugated pMHC complexes only. Cells were sorted by using the BD FACSAria flow cytometer, and PE ⁺ cells were collected. V(D)J immune profiling of sorted cells was done with scRNA-Seq, using the 10X Genomics Chromium Single Cell Immune Profiling Workflow at the UCLA Clinical Microarray Core. Each T cell was encapsulated in an oil emulsion droplet with a barcoded gel bead, and reverse transcription was performed to create a barcoded cDNA library. The V(D)J-enriched and gene expression libraries were sequenced using the 10X Genomics Chromium Controller. After sequencing, the Cell Ranger pipeline was used to align reads, filter, count barcodes and assign unique molecular identifiers. [0316] Next-generation immune repertoire sequencing using the immunoSEQ platform. To assess the T-lymphocyte repertoire of bulk expanded TIL populations, the inventors used the immunoSEQ assay (Adaptive Biotechnologies). This multiplex PCR system uses a mixture of primers that target the rearranged V and J segments of the CDR3 region to assess TCR diversity within a given sample. Genomic DNA from each sample was extracted by using the QIAamp DNA Blood Midi Kit (Qiagen, cat. no. 51185). The inventors provided at least 1 pg of DNA (-60,000 cells) from each sample to Adaptive Biotechnologies for sequencing at a deep resolution. Resulting sequencing data were analyzed with the immunoSEQ Analyzer Platform (Adaptive Biotechnologies).

[0317] High-throughput ab TCR pairing using the pairSEQ platform. The inventors provided Adaptive Biotechnologies with frozen bulk expanded TIL samples for their pairSEQ assay, to predict which a and b chains may pair to form a functional TCR. Briefly, T cells were randomly distributed into wells of a 96-well plate. The mRNA was extracted, converted to cDNA, and amplified by using TCR-specific primers. The cDNA of T cells from each well was given a specific barcode, and all wells were pooled together for sequencing. Each TCR sequence was mapped back to the original well through computational demultiplexing. Putative TCR pairs were identified by examining whether a sequenced TCR a chain was frequently seen to share the same well with a specific sequenced TCR b chain, above statistical noise.

[0318] The 22 UCLA GBM RNA-Seq data generated for this study were uploaded to BioProject database (BioProject: PRJNA577155). For the IRIS proteo-transcriptomics analysis, matching RNA-Seq data and MS immunopeptidomics data of B-LCL-S1 and B-LCL- S2 cell lines were retrieved from Laumont et al. (GEO: GSM1641206, GSM1641207 and PRIDE: PXD001898). Raw RNA-Seq data of the JeKo-1 lymphoma cell line were obtained from the Cancer Cell Line Encyclopedia via the NCI Genomic Data Commons. Corresponding MS immunopeptidomics MS data of JeKo-1 were retrieved from Khodadoust et al. (PRIDE: PXD004746). B. Tables

Table la. IRIS MS analysis of AS-derived epitopes in cell line immunopeptidomics datasets, a. JeKo-1 cancer cell line with FDR = 5%.

Table lb. IRIS MS analysis of AS-derived epitopes in cell line immunopeptidomics datasets, b. B-LCL-S1 normal cell line with FDR = 5%

Table lc. IRIS MS analysis of AS-derived epitopes in cell line immunopeptidomics datasets, c. B-LCL-S2 normal cell line with FDR = 5%.

Table 2a. IRIS screening results of tumor AS events in 22 GBM samples, a. IRIS identified 6,276 tumor-associated AS events (Primary set)

AS event AS_event AS event

ENSG0000

6:- ENSGOOOOO 132781 :MUTYH:chrl : -

ENSG00000117410:ATP6V0B:chrl:+:4 : 1487817: 14 :45798062:45798160:45797982:457

4441336:44441520:44440779:44441761 0 98434

ENSG0000 ENSGOOOOO 124831 :LRRFIP1 :chr2:

ENSG00000028203:VEZT:chrl2:+:9565 1318385:11 +:238636518:238636578:238629465 0925:95651015:95645847:95656681 329240 :238647874 ENSG00000043143 :JADE2:chr5:+: 1339 ENSG00000219545:UMADl:chr7:+ ENSG00000124074:ENKDl:chrl6:- 12457:133912728:133909452:13391418 :7907960:7908164:7841374:791691 :67697559:67697723 :67697459:676 6 1 99973

ENSG00000104936:DMPK:chrl9:- ENSGOOOOO 109452 :INPP4B :chr4 :- :46274228:46274318:46273898:4627482 ENSG00000008517:IL32:chrl6:+:3 : 143081510: 143081714: 143067149: 5 117984:3118011:3117416:3118180 143094784

ENSG00000079841:RIMSl:chr6:+: ENSG00000081377:CDC14B:chr9:-

ENSG00000127603 :MACF1 :chrl :+:398 72975662:72975752:72970470:7299 :99277930:99278074:99266071:992 44132:39844195:39838268:39844874 3749 84787 ENSG00000124067:SLC12A4:chrl6:- ENSG00000149177:PTPRJ:chrll:+: ENSG00000130706:ADRMl:chr20: :67984556:67984614:67984396:6798504 48168427:48168515:48166676:4817 +:60883423:60883526:60883234:60 2 0998 883710

ENSG00000166532:RIMKLB:chrl2 ENSG00000271447:MMP28:chrl7:-

ENSG00000117600 :PLPPR4:chrl:+:997 :+:8852380:8853210:8850893:8866 :34093215:34093913:34083438:340 67279:99767453:99766522:99771240 406 94770

ENSG00000005379:TSPOAP1 :chrl

ENSG00000120697 : ALG5 :chrl 3 : - ENSG00000111271 : ACAD 10:chrl2 7:- :37569125:37569172:37567809:3756956 :+: 112191575: 112191719: 11218714 :56381698:56381760:56379808:563

1 9:112193471 82421

ENSG00000047249:ATP6VlH:chr8

ENSG00000151789 :ZNF385D :chr3 : - ENSG00000214435:AS3MT:chrl0: :21552352:21552515:21478695:2160606 +: 104629840: 104629968: 10462935 :54723723:54723777:54714456:547

5 0:104632204 27221

ENSG00000005194:CIAPINl:chrl6:- ENSGOOOOO 140157 :NIP A2 :chr 15 : - ENSG00000138430:OLAl:chr2:-

:57474683:57474895:57473207:5748125 :23033277:23033413:23027922:230 : 175111442: 175111543: 175094179:

3 34146 175113179

ENSG00000183317:EPHA10:chrl:- ENSG00000196353:CPNE4:chr3:-

:38186454:38186516:38186226:3818733 : 131624107: 131624288: 131442469: ENSG00000185988:PLK5:chrl9:+:

1 131753410 1528896:1528973:1528427:1529404 ENSG00000116584: ARHGEF2:chr

ENSG00000158882:TOMM40L:chrl:+: ENSG00000146574:CCZlB:chr7:- 1:-

161197425:161197527:161196394:1611 :6852606:6852668:6851694:685439 : 155935421: 155935551:155935203:

97673 4 155936206

ENSG00000186166:CCDC84:chrll ENSG00000104866:PPPlR37:chrl9

ENSG00000100379:KCTD17:chr22:+:3 :+: 118883941: 118883972: 11888199 :+:45643493:45643539:45596785:4

7457143:37457215:37455478:37457578 3:118885703 5643763

ENSG00000197223:ClD:chr2:- ENSG00000072518 :MARK2:chrl 1 : ENSG00000107077:KDM4C:chr9:+

:68280192:68280418:68274451:6829007 +:63671457:63671619:63670630:63 :7105401:7105500:7103870:712806

6 672257 5 ENSG00000073605:GSDMB:chrl7:

ENSG00000144134:RABL2A:chr2:+:ll ENSG00000071054:MAP4K4:chr2:

4398932:114399027:114392707:114399 :38065210:38065295:38062524:380 +: 102480282: 102480513 : 102476326

357 66008 :102481391

ENSG00000130540: SULT4A1 :chr2

ENSG00000095637:SORBSl:chrl0:- ENSG00000135597:REPSl:chr6:- 2:- :97110965:97111133:97106209:9711463 : 139247537: 139247615: 139242261: :44223393:44223520:44221993:442 8 139251113 24939

ENSG00000006283 : CACNA1 G:chrl7 :+ ENSG00000152154:TMEM178A:ch ENSG00000106077 : ABHD 11 :chr7 :- :48684260:48684350:48681642:4868518 r2:+:39931220:39931334:39893514: :73151258:73151440:73151021:731 7 39944149 51891

ENSG00000134909:ARHGAP32:ch

ENSG00000138757:G3BP2:chr4:- ENSG00000143207:RFWD2:chrl:- rll:- :76649239:76649360:76587233:7664945 : 176145045: 176145143: 176118210: : 128910822: 128910904: 128868363: 9 176153768 128932174

ENSG00000108395:TRIM37:chrl7:

ENSG00000154134:ROB03:chrll:

ENSG00000162929:KIAA1841:chr2:+:6 +:124747832: 124748027: 12474755 :57078958:57079102:57076820:570 1324834:61324987:61319722:61330987 4:124748193 89688 ENSG00000178035 : IMPDH2 : chr3 : - ENSG00000205937:RNPSl:chrl6:- ENSG00000075391:RASAL2:chrl: :49065631 :49065755 :49065349:4906586 :2317175:2317219:2314761:231805 +: 178439827: 178439858: 178436556

3 5 : 178442209

ENSG00000079819:EPB41L2 :chr6 :

ENSG00000162910:MRPL55:chrl:- ENSG00000137177:KIF13A:chr6:-

:228296655:228296722:228296019:2282 : 17771344: 17771449: 17765177: 177 : 131191467: 131191521: 131191266:

96849 72138 131206235

ENSG00000137877: SPTBN5 :chrl5 : - ENSG00000139624:CERS5:chrl2:- ENSG00000165661:QSOX2:chr9:-

:42145779:42145985:42145645:4214624 :50535835:50535893:50532400:505 : 139113641: 139113787: 139111010:

7 36856 139115852

ENSG00000204278:TMEM235:chrl7:+: ENSG00000117114: ADGRL2:chrl : ENSG00000274769:RP11-

76230673:76230811:76228294:7623510 +:82452584:82452713:82451039:82 493E12.3:chr2:+:61344491:6134452

4 456074 0:61343205:61344601

ENSG00000196535:MY018A:chrl ENSG00000277363 : SRCINl :chrl7:

ENSG00000188674 : C2orf80 : chr2 : - 7:- :209049674:209049756:209047771 :2090 :27412621:27412666:27409456:274 :36724458:36724482:36720549:367 54676 13455 34742

ENSG00000089159:PXN:chrl2:- ENSG00000196204 :RNF216P 1 : chr ENSG00000137486 : ARRB 1 :chrl 1 : - : 120653732: 120653893: 120653464: 1206 7:+:5035105:5035213:5024706:503 :74982744:74982768:74980003 :749 54075 6240 83938

ENSG00000105483:CARD8:chrl9:- ENSG00000144115:THNSL2:chr2: ENSG00000108387:SEPT4:chrl7:- :48726975:48727125:48725112:4873369 +:88472769:88472892:88469975:88 :56604042:56604339:56603674:566 4 474157 06475

ENSG00000124357:NAGK:chr2:+: ENSG00000185920:PTCHl:chr9:-

ENSG00000129159:KCNC1 :chrl 1 :+: 17 71302684:71302740:71300724:7130 :98236293:98236425:98232213:982 803216:17803448:17801191:17875089 3733 38315

ENSG00000080823:MOK:chrl4:- ENSG00000033627: ATP6V0A1 xhr

ENSG00000127663:KDM4B:chrl9:+:51 : 102744942: 102745031:102718332: 17:+:40666306:40666478:40665996

19128:5119230:5110829:5119663 102749814 :40673044

ENSG00000100568:VTIlB:chrl4:- ENSG00000088899:LZTS3:chr20:- ENSG00000141568:FOXK2:chrl7:

:68129745:68129907:68129252:6814109 :3148383 :3148607:3147827:315410 +:80541888:80542064:80529746:80

1 0 543779

ENSG00000139116:KIF21A:chrl2:- ENSG00000104164:BLOClS6:chrl ENSG00000138028:CGREFl:chr2:- :39711874:39712003:39709772:3971646 5:+:45884332:45884474:45880074: :27323283 :27323410:27322708:273 9 45895297 24964

ENSG00000109103:UNC119:chrl7:

ENSG00000198925 : ATG9 A:chr2 :-

ENSG00000172995:ARPP21:chr3:+:357 :26875609:26875723:26874867:268 :220093155:220093204:220092775: 50460:35750562:35732497:35756930 79355 220094256 ENSG00000119487 :MAPKAP 1 : chr9 : - ENSG00000099783 :HNRNPM:chrl ENSG00000102904:TSNAXIPl:chr : 128434594: 128434922: 128432186: 1284 9:+:8538547:8538592:8536311:853 16:+:67860865 :67860975 :67860747 69249 9050 :67861151

ENSG00000144504:ANKMYl:chr2:- ENSG00000155366:RHOC:chrl:- ENSG00000127989:MTERFl:chr7:-

:241468453:241468926:241465266:2414 : 113247721: 113248874: 113246428: :91509368:91509427:91504078:915

92330 113249699 09970

ENSG00000047849:MAP4:chr3:-

ENSG00000101333:PLCB4:chr20:+:935 :47960208:47960331:47919013:479 ENSG00000092421 : SEMA6 A:chr5 :

3693:9353751:9353050:9360700 69717 : 115808580: 115808631 : 115783507: 115808768

ENSG00000067221 : STOML 1 xhrl 5

ENSG00000105419:MEIS3:chrl9:-

ENSG00000110514:MADD:chrll:+:472 :47918307:47918358:47912804:479 :74281448:74281598:74281143:742

95377:47295527:47291301:47296113 19908 82691

ENSG00000278259:MY019:chrl7> ENSG00000136960:ENPP2:chr8:- ENSG00000147813:NAPRT:chr8:-

:34857691:34857741:34857075:3485893 : 120584415: 120584490: 120583081: : 144657360: 144657515: 144657070:

6 120592355 144657592

ENSG00000061273:HDAC7:chrl2:- ENSG00000141556:TBCD:chrl7:+: ENSG00000144711 :IQSEC1 :chr3 :-

:48189688:48189799:48189550:4818998 80867160:80867183:80863929:8086 : 12944272: 12944322: 12943022: 129

9 9633 49848

ENSG00000147010:SH3KBPl:chrX:- ENSG00000135541:AHIl:chr6:- ENSG00000151778:SERP2:chrl3:+ : 19713112: 19713169: 19702146: 1971372 :135622545:135622677:135621696: :44964492:44964714:44953849:449 9 135639656 71407

ENSG00000174606 : ANGEL2 :chrl :- ENSG00000125954:CHURC1- ENSG00000020129:NCDN:chrl:+:3 :213186434:213186760:213181808:2131 FNTB:chrl4:+:65392724:65392798: 6023756:36023824:36023484:36024 88954 65390844:65398855 707

ENSG00000184182:UBE2F:chr2:+: ENSGOOOOO 196652:ZKSCAN5 xhr

ENSG00000091073:DTX2:chr7:+:76092 238925207:238925275:238903451:2 7:+:99117449:99117532:99110214:

861:76093026:76091153:76109737 38933982 99123435

ENSG00000166261 :ZNF202:chrl 1 :

ENSG00000054690:PLEKHHl:chrl

ENSG00000099785:MARCH2:chrl9:+:8 : 123598183: 123598303: 123597699: 4:+:68053526:68053666:68052814:

483420:8483691:8478304:8491492 123598840 68053790

ENSG00000150712:MTMR12:chr5:

ENSG00000088387 :DOCK9 :chrl 3 :- ENSG00000198513:ATLl:chrl4:+: :99448459:99448467:99447002:9944936 :32233878:32234040:32230453:322 51096712:51096727:51095180:5109 8 39106 8946

ENSG00000176049:JAKMIP2:chr5:

ENSG00000124214:STAUl:chr20:- ENSG00000178127:NDUFV2:chrl

:47782533:47782822:47770608:4779073 8:+:9124871:9124994:9119588:912 : 146981303: 146981374: 146971249:

1 6828 146991868

ENSG00000161010:MRNIP:chr5:- ENSG00000145901:TNIPl:chr5:-

ENSG00000148057:IDNK:chr9:+:86243 : 179278242: 179278424: 179275066: : 150444520: 150444692: 150443308:

787:86243874:86238136:86256462 179280196 150460440

ENSG00000160993:ALKBH4:chr7:

ENSGOOOOO 197467: COL 13 A1 xhrl

ENSG00000132600 :PRMT7 :chrl6 :+:68 : 102100050: 102100157: 102098428: 0:+:71700743:71700779:71697471: 355328:68355365:68349977:68358585 102105160 71703880

ENSG00000090975:PITPNM2:chrl

2:- ENSG0000025846LRP11-

ENSG00000119844:AFTPH:chr2:+:6480 : 123476301: 123476445: 123475256: 164J13.1:chrl5:+:42682150:426822

6619:64806680:64800202:64812555 123477045 94:42681294:42684836

ENSG00000090372:STRN4:chrl9:- ENSG00000064651 : SLC12 A2 :chr5 :

ENSG00000132275 :RRP8 :chrl 1 : - :47242041:47242145:47234130:472 +: 127512796: 127512844: 127510358 :6622155:6622832:6622005:6624633 49405 :127514258

ENSG00000139597 :N4BP2L 1 xhrl

ENSGOOOOO 161677 : JO SD2 : chrl 9 : - 3:- ENSG00000137814:HAUS2:chrl5: :51010830:51010956:51009829:5101437 :32978457:32978534:32977337:329 +:42852979:42853068:42851606:42 3 81781 853467

ENSG00000255036:RP11- ENSG00000143486:EIF2D:chrl:-

ENSG00000130255:RPL36:chrl9:+:568 23 J9.4:chr9:+: 100126332: 10012641 :206773086:206773190:206772446:

4975:5685130:5681282:5690041 0:100124723:100127954 206773616

ENSG00000161835:GRASP:chrl2: ENSG00000186868:MAPT:chrl7:+:

ENSG00000068724:TTC7A:chr2:+:4717 +:52404822:52404991:52404719:52 44091608:44091690:44074030:4409

8740:47178872:47177665:47183977 407470 5983

ENSG00000226210:ABC7- ENSGOOOOO 138606: SHF xhrl 5 : -

ENSG00000147576:ADHFEl:chr8:+:67 42389800N19.1:chrl2:+:87880:880 :45464080:45464200:45460331:454

357452:67357649:67356983:67359498 17:87703:88569 67416

ENSG00000144591:GMPPA:chr2:+:220 ENSG00000178602:OTOS:chr2:- ENSGOOOOO 136044 : APPL2:chrl2 : -

370416:220370483:220370277:2203707 :241079685:241079861:241079505: : 105570653 : 105570794: 105569860:

01 241080036 105571003

ENSG00000115761 :NOL10:chr2:- ENSG00000139746:RBM26:chrl3:- ENSG00000103168:TAFlC:chrl6:- : 10784445 : 10784498: 10747437: 1079786 :79927287:79927359:79918929:799 :84218456:84218505:84217384:842 7 28573 20506 ENSG00000153443:UBALDl:chrl6

ENSG00000170871:KIAA0232:chr

ENSG00000169188:APEX2:chrX:+:550 4:+:6878386:6878484:6873409:688 :4660493:4660657:4659984:466467

28683:55028864:55028062:55029394 2513 8

ENSG00000283196:RP4-

614C10.2:chr2:- ENSG00000156990:RPUSD3:chr3:- ENSG00000095794:CREM:chrl0:+:

:91842945:91843023:91825059:9184339 :9883882:9883927:9883766:988557 35490378:35490414:35485027:3549

3 3 5822

ENSG00000166582:CENPV:chrl7:- ENSG00000138326:RPS24:chrl0:+: ENSGOOOOO 103121 : CMC2 : chrl 6 : - : 16252453: 16252647: 16251999: 1625324 79797722:79797740:79797062:7979 :81031889:81031959:81015482:810

4 9961 40338

ENSGOOOOO 198795 :ZNF521 :chrl 8:

ENSG00000144040 : SFXN5 : chr2 : - ENSG00000125686:MEDl:chrl7:- :73195576:73195662:73172228:7321538 :37596638:37596771:37595446:375 :22930870:22930957:22902151:229 6 96875 31968

ENSG00000115685 :PPPlR7:chr2:+:242 ENSG00000110514:MADD:chrll:+ ENSG00000163072:NOSTRIN:chr2 092897:242093019:242089962:2420972 :47310518:47310578:47308085:473 :+: 169711861: 169711970: 16970791 21 10941 4:169713199

ENSG00000125676:THOC2:chrX:- ENSGOOOOO 169241 : SLC50A1 :chrl :

ENSG00000007545 :CRAMP1 :chrl6:+: 1 : 122747489: 122747559: 122745367: +: 155109303: 155109427: 155108852

716073:1716178:1715139:1716422 122747902 : 155110454

ENSG00000121753:ADGRB2:chrl:- ENSG00000164896:FASTK:chr7:-

:32221599:32222416:32210332:3222948 : 150775648: 150775788: 150775179: ENSG00000163702:IL17RC:chr3:+:

4 150777771 9974503:9974542:9974387:9974636 ENSG00000262223 :RP11 -

ENSG00000166167:BTRC:chrl0:+:1031 ENSG00000198836:OPAl:chr3:+:l 1055B8.3:chrl7:-

90101:103190209:103113985:10322173 93343880:193343991:193336725:19 :79355676:79355740:79354384:793

7 3349400 58928

ENSG00000175387:SMAD2:chrl8:

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000159082:SYNJl:chr21:-

1700035:131700223:131698924:131702 :45396845:45396935:45395807:454 :34072147:34072415:34067592:340

877 22891 74270

ENSG00000114395 :CYB561D2:chr3:+: ENSG00000008710 :PKD 1 :chrl6 :- ENSG00000021645:NRXN3:chrl4: 50389439:50389477:50388991:5039067 :2142954:2143094:2142189:214354 +:80271454:80271542:80164280:80 1 4 327381

ENSG00000214174:AMZ2Pl:chrl7

ENSG00000062598 :ELM02 : chr20 : - ENSG00000050130:lKAMP:chrl4:

:45015976:45016070:45014914:4501767 :62969359:62969635:62969045:629 +:59953430:59953522:59951311:59

7 70672 954391

ENSG00000114541 :FRMD4B:chr3:

ENSGOOOOO 150627 :WDR17 :chr4 :+:

ENSG00000138443:ABI2:chr2:+:20426 :69336902:69336987:69299250:693 177087274: 177087295 : 177084444: 1

1606:204261690:204260503:204267298 51493 77089822

ENSG00000227036:LINC005 llxhr

ENSG00000138614:INTS14:chrl5:- ENSGOOOOO 113108 : APBB 3 : chr5 : - 17:-

:65899496:65899780:65897574:6590343 : 139941428: 139941434: 139941286: :70416840:70417105:70400957:704

5 139941684 24376

ENSG00000153391:IN080C:chrl8:

ENSG00000081803:CADPS2:chr7:- ENSG00000100938:GMPR2:chrl4: : 122054121: 122054130: 122047750: 1220 :33058245:33058313:33048706:330 +:24703312:24703447:24702546:24 56114 77682 704942

ENSG00000099204:ABLIMl:chrl0

ENSG00000198157:HMGN5 xhrX: - ENSG00000138443:ABI2:chr2:+:20

:80374228:80374279:80373984:8037703 : 116213137: 116213242: 116211430: 4246911:204246929:204245107:204

3 116225456 255768

ENSG00000134444:KIAA1468:chrl8:+: ENSG00000198838:RYR3:chrl5:+: ENSG00000048162 :NOP 16 : chr5 : -

59947592:59947675:59947089:5994787 34148084:34148252:34147113:3414 : 175815235: 175815344: 175812328:

8 9980 175815433

ENSG00000173264:GPR137:chrll: ENSG00000154310:TNIK:chr3:-

ENSG00000075415:SLC25A3:chrl2:+:9 +:64055536:64055686:64055418:64 : 170846502: 170846667: 170843940:

8989210:98989335:98987913:98991633 055811 170855979

ENSG00000115977:AAKl:chr2:- ENSG00000163466:ARPC2:chr2:+:

ENSG00000108509:CAMTA2:chrl7:- :69706082:69706193:69704122:697 219103386:219103573:219093573:2 :4885383:4885522:4885126:4886051 07991 19110142

ENSG00000065559:MAP2K4:chrl7 ENSG00000100239:PPP6R2:chr22:

ENSG00000008382:MPND:chrl9:+:435 :+: 11958205: 11958308: 11924318:1 +:50830295:50830444:50810579:50

4945:4355018:4354417:4357249 1984672 832321 ENSG00000136828:RALGPSl:chr9:+:l ENSG00000186001 :LRCH3 :chr3 :+: ENSG00000002919: SNX11 :chrl7 :+

29958752:129958910:129957496:12997 197607382 : 197607628 : 197602646 : 1 :46189392:46189473:46185200:461

4409 97610411 90662

ENSG00000144199:FAHD2B:chr2:

ENSG00000101746:NOL4:chrl8:-

ENSG00000278535:DHRSll:chrl7:+:34 :97757599:97757725:97757449:977 :31537289:31537481:31523142:315

951400:34951610:34948586:34954591 60437 38202

ENSG00000180354 :MTURN:chr7 : ENSG00000064787 :BCAS 1 :chr20: -

ENSG00000172766:NAA16:chrl3:+:419 +:30185792:30185915:30174914:30 :52573970:52574036:52570234:525

29279:41929352:41910892:41932439 197053 83444

ENSG00000137962:ARHGAP29:ch

ENSG00000183401:CCDC159:chrl9:+: ENSG00000116337:AMPD2:chrl:+ rl>

11462581 : 11462649: 11460875 : 1146273 : 110167924: 110168055: 110163888: :94696962:94697199:94685948:947 2 110168283 02970

ENSG00000227544:AC018647.3:chr7:+: ENSG00000122786:CALDl:chr7:+: ENSG00000169696:ASPSCRl:chrl

35756640:35756738:35756478:3575867 134620438:134620516:134618141:1 7:+:79954295:79954722:79943483:

9 34625842 79966912

ENSG00000165801:ARHGEF40:chrl4: ENSG00000082898 :XP01 :chr2 : - ENSG00000111711:GOLTlB:chrl2

+:21555478:21555622:21554025:215561 :61761692:61761813:61761038:617 :+:21661316:21661495:21659910:2

26 64696 1665228

ENSG00000135407:AVIL:chrl2:- ENSG00000142920:AZIN2:chrl:+: ENSG00000178188:SH2Bl:chrl6:+

:58195942:58196131:58194995:5819702 33547778:33548743:33547109:3354 :28884490:28884590:28884026:288

9 9554 84767

ENSG00000140688:C16orf58:chrl6

ENSG00000167524:SGK494:chrl7:- ENSG00000149932:TMEM219:chr

:26939279:26939384:26939102:2693963 16:+:29983362:29983461:29982899 :31504787:31504845:31503661:315

5 :29984270 04923

ENSG00000204681 : GABBRl :chr6 :

ENSG00000155189:AGPAT5:chr8:

ENSG00000107036:RICl:chr9:+:575353 +:6582390:6582460:6566408:66125 :29577005:29577156:29576510:295

5:5753646:5753238:5754840 71 78700

ENSG00000138162 : TACC2 : chrl 0 : ENSG00000186591:UBE2H:chr7:-

ENSG00000127054:INTS11 :chrl :- +: 123988860: 123989001: 12398752 : 129498741: 129498781: 129479175: : 1258560: 1258667: 1256473 : 1259960 3:123996909 129519407

ENSG00000070770:CSNK2A2:chrl

ENSG00000075151 :EIF4G3 xhrl : - 6:-

ENSG00000237651:C2orf74:chr2:+:613 :21329205:21329301:21307720:213 :58218163:58218214:58208414:582

89976:61390090:61372331:61390186 77358 30636

ENSG00000205581:HMGNl:chr21: ENSG00000073921 :PICALM:chrl 1

ENSG00000096070 :BRPF3 :chr6 :+: 3619 :40717755:40719218:40717200:407 :85671717:85671820:85670103:856 6678:36196833:36193141:36198202 19304 85750 ENSG00000196295:AC005154.6:chr7:- ENSG00000184792 :0SBP2 :chr22 :+ :30590933:30591095:30590397:3060334 :31285476:31285623:31285221:312 ENSG00000101276:SLC52A3:chr2 6 86714 0:-:745851:746469:744647:748940

ENSG00000185379:RAD51D:chrl7:- ENSG00000176731:C8orf59:chr8:- ENSG00000090097:PCBP4:chr3:-

:33434006:33434141:33433500:3344551 :86131464:86131589:86129731:861 :51996825:51996908:51995320:520

9 32534 01341

ENSG00000132906:CASP9:chrl:- ENSG00000114316:USP4:chr3 :- ENSG00000104866:PPPlR37:chrl9 : 15831105: 15831253: 15821947: 1584460 :49348946:49349087:49348170:493 :+:45641771:45641869:45596785:4 4 62134 5643763

ENSG00000260807:RP11-

ENSG00000167766:ZNF83:chrl9:- ENSG00000258289:CHURCl:chrl 161M6.2:chrl6:- :53119970:53120128:53118050:5312218 4:+:65392727:65392798:65390844: : 1026326: 1026400: 1025995 : 102677 8 65398855 7

ENSG00000075826:SEC31B:chrl0:

ENSG00000187193:MTlX:chrl6:+:

ENSG00000091073:DTX2:chr7:+:76126 56717076:56717298:56716480:5671 : 102256891: 102257037: 102256188: 653:76126794:76121570:76129757 7869 102257423 ENSG00000245937:LINC01184:chr5:- ENSG00000115657: ABCB6:chr2:- ENSG00000075043 :KCNQ2 :chr20 :- : 127398061: 127398192: 127396936: 1274 :220081373:220081554:220081187: :62050971 :62051025 :62046479:620 18661 220082391 55529

ENSG00000179314:WSCDl:chrl7:

ENSG00000110075 :PPP6R3 :chrl 1 :+:68 +:6012926:6013086:5998543:60213 ENSG00000114026:OGG1 :chr3 :+:9 376940:68377096:68370960:68377371 07 800870:9800970:9798500:9807492 ENSG00000163618 : C ADPS : chr3 : -

ENSG00000048342:CC2D2A:chr4:+:15 :62498425 :62498443 :62484943 :625 ENSG00000132530:XAFl:chrl7:+:

480842:15480952:15480430:15482327 01733 6665204:6665356:6663920:6665473

ENSG00000078403:MLLT10:chrl0 ENSG00000070010 :UFD 1L :chr22: -

ENSG00000177728:TMEM94:chrl7:+:7 :+:21906040:21906136:21903853:2 :19462992:19463125:19459331:194 3484839:73484991:73482507:73485346 1940601 66605 ENSG00000149131: SERPING1 :chrl 1 :+: ENSG00000148120 : C9orf3 :chr9 :+: ENSG00000100239:PPP6R2:chr22: 57367336:57367850:57365794:5736950 97844856:97845001:97843062:9784 +:50827414:50827540:50810579:50

7 8963 832321

ENSG00000123636:BAZ2B:chr2:- ENSG00000079841:RIMSl:chr6:+:

ENSG00000119844:AFTPH:chr2:+:6480 : 160257109: 160257175: 160255405: 72678685:72678766:72596890:7280

6619:64808407:64800202:64812555 160261359 6651

ENSG00000254870:ATP6V1G2- ENSG00000175662:TOMlL2:chrl7

DDX39B:chr6:- ENSG00000126773:PCNX4:chrl4:

:31506539:31506632:31504460:3150809 +:60574303:60575045:60559137:60 : 17810760: 17810840: 17801988: 178

8 581417 75575

ENSG00000146707:POMZP3:chr7: ENSG00000120832:MTERF2:chrl2

ENSG00000135502:SLC26A10:chrl2:+:

58019407:58019535:58019247:5801978 :76240770:76240908:76239532:762 : 107378892: 107378993 : 107372549:

0 47499 107380746

ENSG00000100350:FOXRED2:chr

ENSG00000136754:ABIl:chrl0:- 22:-

ENSG00000197381:ADARBl:chr21:+:4 :27047990:27048167:27044670:270 :36900561:36900813:36897454:369 6548316:46548488:46494708:46591524 54146 01942 ENSG00000160201 :U2 AF 1 : chr21 : - ENSG00000115310:RTN4:chr2:- ENSG00000142168:SODl:chr21:+: :44521475:44521542:44520629:4452442 :55255299:55255356:55214834:552 33036102:33036199:33033021:3303 4 76880 9570

ENSG00000101199:ARFGAPl:chr20:+: ENSG00000245910:SNHG6:chr8:- ENSG00000068903 : SIRT2 :chrl 9:-

61915202:61915232:61914203:6191621 :67834558:67834627:67834349:678 :39384053:39384167:39380784:393

7 34848 90145

ENSG00000083807: SLC27 A5 :chrl

ENSG00000219626 :FAM228B :chr2 9:-

ENSG00000100889:PCK2:chrl4:+:2456 :+:24384375:24384483:24358057:2 :59010151:59010282:59010058:590

9203:24569422:24568929:24571961 4387067 10489

ENSG00000148481:MINDY3:chrl0

ENSG00000150712:MTMR12:chr5:- ENSG00000139644:TMBIM6:chrl2

:32235067:32235235:32230453:3223910 :+:50135739:50135898:50135394:5 : 15880226: 15880278: 15879317: 158

6 0146246 83424

ENSG00000072110:ACTNl:chrl4:- ENSG00000137601:NEKl:chr4:- ENSG00000154358:OBSCN:chrl:+:

:69345705:69345786:69345240:6934667 : 170476870: 170477002: 170459062: 228492823 :228493087:228492267:2

8 170477082 28494072

ENSG00000129675:ARHGEF6:chr

ENSG00000122678:POLM:chr7:- X:-

ENSG00000007392:LUC7L:chrl6:- :44113729:44113819:44113624:441 : 135760094: 135760115: 135758876:

:258599:258663:258187:277240 13996 135761693

ENSG00000138380:CARF:chr2:+:2 ENSG00000159063 : ALG8 :chrl 1 : -

ENSG00000181666:HKRl:chrl9:+:3782 03831700:203831821:203826149:20 :77838403:77838482:77835260:778 6070:37826159:37825684:37838091 3834641 50539 ENSG00000116641 :DOCK7 :chrl :- ENSG00000007516:BAIAP3:chrl6: :62953068:62953083:62943496:6295460 ENSG00000164828:SUNl:chr7:+:8 +: 1396934: 1396956: 1396685: 13972 4 82977:883157:881767:891020 98 ENSG00000215908 : CROCCP2 :chr ENSG00000215039:CD27-

ENSG00000144935 :TRPC1 :chr3 :+: 1425 1:- ASl:chrl2:- 11665: 142511809: 142503882: 14252101 : 16969522: 16969640: 16961663 : 169 :6560035:6560146:6557903:656063 0 71140 4

ENSG00000147586:MRPS28:chr8:- ENSG00000271147 : ARMCX5- ENSG00000142875:PRKACB:chrl: :80940929:80941031:80915415:8094213 GPRASP2:chrX:+: 101856391: 1018 +:84639011:84639035:84630105:84 9 56437:101854775:101860409 640715

ENSG00000186364:NUDT17:chrl:- ENSG00000152726:FAM21B:chrl0 ENSG00000134684 : YARS :chrl :- : 145588377: 145588635: 145587818: 1455 :+:47915877:47915964:47913703:4 :33276191:33276367:33272212:332 88871 7919941 82788

ENSG00000164188 :RANBP3L:chr

ENSG00000134262:AP4Bl:chrl> 5:- ENSG00000149925:ALDOA:chrl6:

: 114445259: 114445484: 114444507: 1144 :36268294:36268369:36265622:362 +:30066492:30066648:30064820:30 47226 69491 075049 ENSG00000075151 :EIF4G3 xhrl :- ENSG00000129103:SUMF2:chr7:+: ENSG00000167721:TSRl:chrl7:-

:21327691:21327805:21307720:2132920 56142278:56142429:56140804:5614 :2239330:2239434:2239024:223962

5 4526 4

ENSG00000183762 :KREMEN1 :chr22 :+ ENSG00000128294:TPST2:chr22:- ENSG00000140416:TPMl:chrl5:+: :29517344:29517469:29494941:2953332 :26940569:26940641:26932452:269 63335667:63336030:63335142:6334 9 86016 9183

ENSG00000110711 : AlPxhrl 1 :+:67 ENSG00000137501:SYTL2:chrll:-

ENSG00000214021:TTLL3:chr3:+:9860 256737:67256926:67250728:672575 :85425455:85425550:85420543:854 505:9860604:9855029:9862229 08 29832 ENSG00000114209:PDCD10:chr3:- ENSG00000188338:SLC38A3:chr3: ENSG00000105053:VRK3:chrl9:- : 167443188: 167443261: 167438061: 1674 +:50254846:50254905:50253253:50 :50512492:50512642:50511083:505 52001 255107 19280

ENSG00000160323:ADAMTS13:chr9:+ ENSG00000168958:MFF:chr2:+:22 ENSG00000136518:ACTL6A:chr3: : 136298760: 136298824: 136298649: 1363 8217229:228217289:228197304:228 +: 179293190: 179293292: 179292255 01948 220392 : 179294004

ENSG00000050426 :LETMD 1 xhrl ENSG00000112320:SOBP:chr6:+:l

ENSG00000149273 :RPS3 :chrl 1 :+:7511 2:+:51451857:51451911:51450285: 07954717:107956673:107854814:10 1737:75111821:75110621:75112683 51453143 7979410

ENSG00000137822:TUBGCP4:chr ENSG00000182973:CNOT10:chr3:

ENSG00000129353 : SLC44 A2 :chrl 9 :+: 1 15:+:43695880:43696040:43694048 +:32778901:32778982:32775036:32 0753572:10753697:10753127:10753954 :43696610 800949

ENSGOOOOO 143416 : SELENBPl : chr

ENSG00000164414:SLC35Al:chr6: 1:-

ENSG00000188811 :NHLRC3 :chrl 3 :+: 3 +:88210225:88210385:88187257:88 : 151341479: 151341665: 151340795: 9616241:39616442:39613848:39618226 210875 151342188

ENSG00000120049:KCNIP2:chrl0:

ENSGOOOOOH9636:BBOFl:chrl4:

ENSG00000100938:GMPR2:chrl4:+:24 +:74500730:74500874:74495952:74 : 103590828: 103590924: 103588956:

703312:24703447:24702804:24704942 507267 103603252

ENSG00000159322:ADPGK:chrl5:- ENSG00000162341 :TPCN2:chrl 1 :+ ENSG00000135763:URB2:chrl:+:2

:73047896:73047995:73045233:7305274 :68848867:68848967:68846488:689 29781605:229781716:229779440:22

7 02902 9783256

ENSG00000153310 :FAM49B :chr8 :- ENSG00000171606:ZNF274:chrl9: ENSG00000082458:DLG3:chrX:+:6 : 130892621: 130892704: 130883742: 1309 +:58721326:58721439:58718568:58 9715257:69715303:69712446:69717 15557 722925 029

ENSGOOOOO 137500 :CCDC90B xhrl

ENSGOOOOO 144040 : SFXN5 : chr2 : - ENSGOOOOO 107105 :EL AVL2 : chr9 : - 1:- :73198698:73198814:73188377:7321538 :23693445:23693484:23692885:237 :82989768:82989872:82985783:829 6 01376 91183

ENSG00000166348:USP54:chrl0:- ENSG00000119231:SENP5:chr3:+:

ENSG00000166908:PIP4K2C:chrl2:+:5 :75279554:75279750:75277505:752 196650284:196650422:196630481:1

7993182:57993221:57992994:57994106 80665 96654666

ENSG00000130055:GDPD2:chrX:+ ENSGOOOOO 115942 : 0RC2 :chr2 : -

ENSGOOOOO 127603 :MACF1 :chrl :+:399 :69644825:69644939:69643232:696 :201791490:201791623:201785862: 25489:39925504:39924921:39926303 45203 201796061 ENSG00000081665:ZNF506:chrl9:- ENSG00000115977:AAKl:chr2:- ENSG00000162385:MAGOH:chrl:- : 19916839: 19916935: 19906469: 1991775 :69723116:69723212:69709944:697 :53699213:53699324:53694626:537 0 32700 01248

ENSGOOOOO 169062 :UPF3 A:chrl 3 :+: 115 ENSG00000162631:NTNGl:chrl:+: ENSG00000136754:ABIl:chrl0:- 051776:115051875:115047602:1150519 107937775:107937948:107691461:1 :27044583:27044670:27040712:270 93 07950303 47990

ENSG00000205981 :DNAJC 19 : chr3 : - ENSG00000167635:ZNF146:chrl9: ENSG00000123352:SPATS2:chrl2: : 180705810: 180705884: 180703784: 1807 +:36709023:36709097:36706098:36 +:49765010:49765073:49761370:49 07387 726560 854552

ENSG00000077157:PPPlR12B:chrl:+:2 ENSG00000172292:CERS6:chr2:+: ENSG00000172831:CES2:chrl6:+:6

02414173:202414356:202411700:20241 169622831 : 169622855 : 169622258: 1 6973119:66973261:66969614:66974

8116 69626019 124

ENSG00000159592:GPBPlLl:chrl: ENSGOOOOO 148660: CAMK2G:chrl 0:-

ENSG00000099840:IZUM04:chrl9:+:2 :46151247:46151292:46126897:461 :75585036:75585105:75583842:755 098974:2099028:2098803 :2099253 53654 87846 ENSGOOOOO 196776 : CD47 : chr3 : - ENSGOOOOO 186166 :CCDC84 xhrl 1 : 107770785: 107770817: 107766139: 1077 ENSG00000164828:SUNl:chr7:+:8 :+: 118883941: 118883972: 11888271 76323 88054:888252:883157:889156 3:118885703 ENSG00000125450:NUP85:chrl7:+ ENSG00000066855:MTFRl:chr8:+:

ENSG00000108474:PIGL:chrl7:+:1613 :73211848:73211918:73209214:732 66601800:66601834:66594686:6660

7284:16137384:16120775:16203201 21197 5878 ENSG00000197622 :CDC42SE1 :chr

ENSG00000103121:CMC2:chrl6:- ENSG00000163913:IFT122:chr3:+: 1:- :81031889:81031959:81031034:8104033 129180070:129180147:129170841:1 : 151029126: 151029262: 151028469: 8 29182402 151031954

ENSG00000196504 :PRPF40 A:chr2 :

ENSG00000127527:EPS15Ll:chrl9:- ENSG00000106638 : TBL2 : chr7 : - : 16487932: 16488065: 16472795: 1649593 : 153535569: 153535623: 153533989: :72990870:72991031 :72988843 :729 9 153535865 92749

ENSGOOOOO 148399 :DPH7 :chr9 :- ENSG00000153707 :PTPRD : chr9 : - ENSG00000133026:MYH10:chrl7:- : 140459344: 140459410: 140459058: 1404 :8497241:8497268:8492979:849964 :8479960:8479990:8473130:848055 59536 6 3

ENSG00000092020:PPP2R3C:chrl

ENSG00000188674 : C2orf80 :chr2: - 4:-

ENSG00000074266 :EED:chrl 1 :+: 85977 :209047688:209047771:209046029: :35579024:35579137:35568590:355 124:85977258:85975305:85988021 209051669 79730 ENSG00000273018:CTD- ENSG00000102984:ZNF821:chrl6: 2303H24.2:chrl7:- ENSG00000049089 : COL9A2 :chrl :-

: 18427090: 18427191: 18422988: 1843188 :40780909:40781081:40780059:407 :71898040:71898145:71894575:719 6 81261 13809

ENSG00000276141 : WH AMMP3 : ch

ENSG00000161395:PGAP3:chrl7:- rl5:- ENSG00000128596:CCDC136:chr7 :37829766:37829903:37829119:3783024 :23196161:23196291:23194899:231 :+: 128454691 : 128454973 : 12844759 5 98509 9:128457811

ENSG00000126768:TIMM17B:chr

ENSG00000102001 : CACNA1F :chrX: - X:- ENSG00000182944:EWSRl:chr22:

:49062075:49062273:49061827:4906297 :48752634:48752784:48752384:487 +:29670256:29670271 :29669853 :29

1 54041 674018

ENSG00000184381:PLA2G6:chr22:

ENSG00000241973:PI4KA:chr22:-

ENSG00000108848:LUC7L3:chrl7:+:48 :38524275:38524437:38522456:385 :21065628:21065749:21065146:210 828657:48828723 :48828213 :48829560 25460 66773

ENSG00000135127:BICDLl:chrl2: ENSG00000119866 :BCLllA:chr2:-

ENSG00000095564:BTAFl:chrl0:+:937 +: 120512246: 120512390: 12050960 :60687816:60688879:60679801:606

23833:93723958:93722435:93740210 5:120518690 89416

ENSG00000249141:RP11-

ENSG00000204152 :TIMM23B :chrl 514012.4:chr6:-

ENSG00000106624:AEBPl:chr7:+:4414 0:+:51374369:51374428:51371646: : 167356506: 167356577: 167352496:

7227:44147299:44147109:44147605 51381438 167369584

ENSG00000197558:SSPO:chr7:+:l ENSG00000145526:CDH18:chr5:-

ENSG00000157326:DHRS4:chrl4:+:244 49513459:149513626:149513177:14 : 19721455: 19721575: 19612710: 197

35140:24435192:24429212:24435491 9514705 47050

ENSG00000272752: STAG3L5P-

ENSG00000157087:ATP2B2:chr3:- PVRIG2P- ENSG00000078018 :MAP2 :chr2 :+:2 : 10575722: 10575817: 10491546: 1066160 PILRB:chr7:+:99950995:99951106: 10555326:210555572:210545551:21 1 99950746:99952765 0557348

ENSG00000130294:KIFlA:chr2:- ENSG00000136059:VILL:chr3:+:38 ENSG00000152894:PTPRK:chr6:-

:241674135:241674162:241666357:2416 043886:38044066:38043351:380457 : 128324341 : 128324377: 128320049:

76479 45 128326228

ENSG00000224924:LINC00320:chr21:- ENSG00000090661 : CERS4 :chrl 9 :+ ENSGOOOOO 129187 :DCTD:chr4:- :22129628:22129735:22116151:2215073 :8315959:8316133:8274378:831938 : 183837033: 183837041: 183836728: 5 2 183837571

ENSG00000089091 :DZANK1 :chr2

ENSG00000123607:TTC21B:chr2:- 0:-

ENSG00000073008:PVR:chrl9:+:45162 : 166719453: 166719575: 166714914: : 18423990: 18424108: 18414409: 184

009:45162168:45161178:45164558 166727306 29627

ENSG00000130477:UNC13A:chrl9

ENSG00000196923:PDLIM7:chr5:-

ENSG00000122545:SEPT7:chr7:+:3587 : 176918404: 176918421: 176918147: : 17760147: 17760153: 17759792: 177 1034:35871106:35840880:35872407 176919405 60317 ENSG00000124006 :OB SL 1 :chr2 :- ENSG00000147912:FBX010:chr9:- ENSG00000129197:RPAIN:chrl7:+ :220422064:220422340:220421445:2204 :37529120:37529257:37525169:375 :5331390:5331531:5326149:533586 23946 31905 1

ENSG00000143776:CDC42BPA:ch ENSGOOOOO 164221 : CCDC112 :chr5

ENSG00000133193:FAM104A:chrl7:- rl:-

:71208816:71208879:71205907:7122330 :227247073 :227247112:227235711 : : 114605399: 114605495: 114604697:

3 227257477 114606909 ENSG00000135597 :REPS 1 : chr6 : - ENSG00000115685 :PPPlR7:chr2:+ ENSG00000183955:KMT5A:chrl2: : 139238691: 139238761: 139235898: 1392 :242092890:242093019:242089123: +: 123873979: 123874101:123868755 41351 242097221 :123875176

ENSG00000125457:MIF4GD:chrl7

ENSG00000133030:MPRIP:chrl7:+

ENSG00000197558:SSPO:chr7:+: 14951 : 17083920: 17083983: 17083402: 170 :73263826:73263982:73263711:732 9600:149519768:149519286:149520440 88136 64163

ENSG00000169884:WNT10B:chrl

ENSG00000075303:SLC25A40:chr7:- 2:- : 87489386:87489484:87488066: 8748988 :49361728:49361789:49360336:493 ENSG00000127419:TMEM175:chr 6 63871 4:+:942198:942403:941942:944208

ENSG00000198561:CTNNDl:chrl ENSG00000076554:TPD52:chr8:-

ENSG00000182511:FES:chrl5:+:91432 1:+:57561481:57561553:57559145: : 80956401:80956443 :80954903 :809

746:91432866:91432673:91433069 57563048 62679

ENSG00000224078 : SNHG14 xhrl 5 ENSG00000239467 : AC007405.6 xh

ENSG00000111752:PHCl:chrl2:+:9068 :+:25226921:25227584:25225231 :2 r2:+: 171633656: 171633687: 171627

656:9068665:9067423:9070225 5244116 697:171633886

ENSG00000242247:ARFGAP3:chr2

ENSG00000135749 :PCNX2 xhrl :- 2:-

ENSG00000197558:SSPO:chr7:+: 14952 :233248590:233248712:233231609: :43206818:43206950:43204896:432 3767:149523910:149523666:149524001 233270758 13147 ENSG00000165644 : COMTD 1 : chrl 0 : - ENSG00000029534:ANKl:chr8:- ENSG00000083857:FATl:chr4:- :76995024:76995130:76994936:7699559 :41557948:41557972:41557066:415 : 187513846: 187513906: 187511557: 2 59067 187516842

ENSG00000125462:Clorf61:chrl:- ENSG00000120899:PTK2B:chr8:+:

ENSG00000168487:BMPl:chr8:+:22035 : 156383847: 156384090: 156377767: 27303310:27303436:27301788:2730

079:22035245:22034652:22035364 156399167 8265

ENSG00000073605:GSDMB:chrl7:

ENSG00000056586:RC3H2:chr9:- ENSG00000082458:DLG3:chrX:+:6 : 125620201: 125620372: 125618157: 1256 :38063213:38063240:38062524:380 9715257:69715303:69712446:69718 20947 66008 369

ENSG00000138246 :DNAJC 13 : chr3 : +: 1 ENSG00000196352:CD55:chrl:+:2 ENSG00000100644:HIFlA:chrl4:+: 32256001:132256110:132249941:13225 07513735:207513853:207512762:20 62212408:62212535:62211531:6221 7019 7532890 3651

ENSG00000089159:PXN:chrl2:- ENSG00000173482:PTPRM:chrl8: ENSG00000284461:RABGEFl:chr7 : 120657009: 120657894: 120653464: 1206 +:8248147:8248174:8247917:82532 :+:66248661:66248828:66240380:6 59425 24 6260497

ENSG00000143393 :PI4KB xhrl : - ENSG00000149557:FEZl:chrll:- : 151282686: 151282731:151280277: 1512 ENSG00000197530:MIB2:chrl:+:l : 125338944: 125339052: 125330562: 99746 560344:1560565:1560281:1560665 125351429 ENSGOOOOO 146151 :HMGCLL lxhr

ENSG00000101198 :NKAIN4 : chr20 : - 6:- ENSG00000140105:WARS:chrl4:- :61873890:61873975:61872858:6187537 :55378845:55378994:55364097:554 : 100841619: 100841687: 100835595:

5 06526 100842596

ENSG00000187838:PLSCR3:chrl7:

ENSG00000111728:ST8SIAl:chrl2:- ENSG00000162585:FAAP20:chrl:- :22408213:22408323 :22402032:2244008 :2121151:2121220:2116952:212507 :7296462:7296683:7296271 :729678 2 7 5

ENSG00000060718 :COL 11 A1 xhrl

ENSG00000100325:ASCC2:chr22:- ENSG00000092295:TGMl:chrl4:-

:30221610:30221769:30221246:3023416 : 103445152: 103445168: 103444991: :24728280:24728455:24727879:247

6 103449693 28909

ENSG00000138002 :IFT172 :chr2 :- ENSG00000165533:TTC8:chrl4:+: ENSG00000241878:PISD:chr22:- :27693794:27693962:27686048:2769511 89300036:89300066:89291165:8930 :32016538:32016585:32015822:320 6 5795 16981

ENSG00000257303 :RP11- ENSG00000128596:CCDC136:chr7

977G19.11:chrl2:+:56706190:56706283: :+: 128457811:128457918: 12845236 ENSG00000134121:CHLl:chr3:+:3

56693971:56708312 6:128461852 84666:384714:383765:386271

ENSG00000123562 :MORF4L2 xhrX:- ENSG00000102125:TAZ:chrX:+:15 ENSG00000175224:ATG13:chrll:+

: 102933426: 102933579: 102931979: 1029 3647881:153647962:153642527:153 :46686398:46686509:46681035:466

40098 648370 86932

ENSGOOOOO 134138 :MEIS2 xhrl 5 : - ENSG00000090857:PDPR:chrl6:+:

ENSGOOOOO 158079 :PTPDC1 :chr9 :+: 968 :37186917:37187013:37184660:371 70164325:70164447:70163025:7016 63847:96864033:96860861:96866556 87351 6053 ENSGOOOOO 197694 : SPTAN1 :chr9 :+: 131 ENSG00000099957 :P2RX6 :chr22 :+ ENSG00000100209:HSCB:chr22:+: 355261:131355321:131353904:1313564 :21377406:21377487:21377324:213 29141851:29141996:29140692:2914 53 77563 7228 ENSG00000081870 :HSPB 11 xhrl : - ENSG00000102385:DRP2:chrX:+:l ENSG00000120318 : ARAP3 :chr5 :- :54394044:54394113:54389620:5440565 00505411 :100505569:100503588: 10 : 141034928: 141034967: 141034002: 7 0505905 141035187

ENSG00000122359:ANXAll:chrl0 ENSG00000204248: COL 11 A2 :chr6

ENSG00000120915:EPHX2:chr8:+:2737 :81932562:81932625:81923899:819 :33152768:33152831:33148947:331

3836:27373915:27369427:27375554 65098 53477

ENSG00000153391:IN080C:chrl8:

ENSG00000140905:GCSH:chrl6:-

ENSG00000073417:PDE8A:chrl5:+:856 :33069295:33069349:33067403:330 :81118067:81118199:81116568:811

64027:85664245:85661070:85669437 77682 24205

ENSG00000128989:ARPP19:chrl5:- ENSG00000170946:DNAJC24:chrl ENSG00000138709:LARPlB:chr4:

:52861044:52861097:52849419:5286131 l:+:31429656:31429877:31392406: +: 129012501: 129012667: 129003460

2 31436357 :129019340

ENSG00000182985 :CADM1 xhrl 1 : ENSG00000159322:ADPGK:chrl5:

ENSG00000135297:MT01:chr6:+:7419 : 115061607: 115061661: 115049495: :73047896:73047995:73045236:730

0015:74190090:74189849:74190397 115069125 52747

ENSG00000124831 :LRRFIP1 :chr2: ENSG00000129351:ILF3:chrl9:+:l

ENSG00000123106:CCDC91:chrl2:+:2 +:238666098:238666191:23866483 0789288:10789380:10787986:10789

8378727:28378794:28343574:28410134 0:238667371 772

ENSG00000128833:MY05C:chrl5:

ENSG00000172869 :DMXL 1 :chr5 :+

ENSG00000158806 :NPM2 :chr8 :+:21882 :52505384:52505483:52504081:525 : 118542528: 118542591: 118539131: 234:21882817:21881768:21882946 06799 118552595 ENSG00000135250:SRPK2:chr7:- ENSG00000225177 :RP11 - ENSG00000067248 :DHX29 :chr5 :- : 104766694: 104766787: 104766321 : 1047 390P2.4:chr6:+: 139015529: 1390156 :54555675:54555772:54552368:545 67439 84:139013754:139017733 62965

ENSG00000228486:LINC01125:chr2:+: ENSG00000142920:AZIN2:chrl:+: ENSG00000163719:MTMR14:chr3:

98318523:98318630:98317767:9831913 33549554:33549728:33547109:3355 +:9739394:9739550:9731827:97434

1 7650 73

ENSG00000168071:CCDC88B:chrl ENSGOOOOO 128973 :CLN6 xhrl 5 : -

ENSG00000011523 :CEP68:chr2:+:6529 1:+:64121475:64121500:64121285: :68503893:68503981:68503656:685

6532:65296935:65283662:65298587 64122665 06627

ENSG00000095397:WHRN:chr9:- ENSG00000223774:RP11- ENSG00000090581:GNPTG:chrl6:

: 117228546:117228672: 117188693 :1172 307B6.3:chrl:+:201868300:201868 +: 1407700: 1407833 : 1402307: 14118

40832 474:201863040:201868857 72

ENSG00000137497 :NUMA1 xhrl 1 :- ENSG00000135622:SEMA4F:chr2: ENSG00000124562:SNRPC:chr6:+:

:71780887:71780957:71747021:7179150 +:74884979:74885078:74884751 :74 34725688:34725731 :34725328:3473

3 889858 0371

ENSG00000198837:DENND4B:chr

ENSG00000122786:CALDl:chr7:+:134 1:- ENSGOOOOO 166147 :FBN1 xhrl 5 : -

620438:134620516:134618828:1346258 : 153914662: 153914832: 153914589: :48720078:48720140:48719970:487

42 153915353 20542

ENSG00000228315:GUSBPll:chr2

2:- ENSG00000101972:STAG2:chrX:+:

ENSG00000157326:DHRS4:chrl4:+:244 :24042912:24043032:24026054:240 123224703:123224814:123224614:1

29110:24429212:24424421:24436419 47615 23227867

ENSG00000135250:SRPK2:chr7:- ENSGOOOOO 173320 : ST0X2 :chr4 :+:

ENSG00000114374 :USP9Y:chrY:+: 149 : 104785729: 104785755: 104783777: 184932739:184932788:184932576:1 30354:14930545:14928279:14945613 104800953 84938241 ENSG00000225190 :PLEKHM1 :chrl7 :- ENSG00000080503 : SMARCA2 xhr ENSG00000078687:TNRC6C:chrl7 :43555265:43555513:43553092:4355980 9:+:2161000:2161035:2159909:216 :+:76093825:76093942:76089844:7 2 1685 6094423

ENSG00000068305 :MEF2A:chrl5 :+: 10 ENSG00000142330:CAPN10:chr2: ENSG00000114859:CLCN2:chr3:- 0243566:100243590:100230633:100246 +:241536266:241536359:24153472 : 184076469: 184076571 : 184076098: 933 1:241537304 184076762

ENSG00000105186:ANKRD27:chr

19:- ENSG00000166387:PPFIBP2:chrll

ENSG00000196235: SUPT5H xhrl 9:+:39 :33137364:33137521:33135385:331 :+:7662263 :7662314:7661101 :7662 948933:39948945:39948380:39949457 40587 709

ENSG00000004399 :PLXND 1 :chr3 :

ENSG00000137210:TMEM14B:chr

ENSG00000077092:RARB:chr3:+:2563 : 129291684: 129291784: 129290687: 6:+: 10755374: 10755465: 10749931 :

5131:25635198:25622213:25636010 129292436 10829239 ENSG00000106976:DNMl:chr9:+: ENSG00000005243 :C0PZ2 :chrl7 : -

ENSG00000010626:LRRC23:chrl2:+:70 130988313:130988452:130985139:1 :46109521:46109599:46106542:461

15008:7015118:7014923:7015572 30996299 11228

ENSG00000080822:CLDND1 :chr3 : ENSG00000089060 : SLC8B 1 :chrl2 :

ENSG00000235501:RP4- 639F20.1:chrl:+:95426872:95426989:95 :98240496:98240547:98240286:982 : 113772247: 113772643 : 113770765: 397541:95428480 41385 113772797 ENSG00000106290 : TAF6 : chr7 : - ENSGOOOOO 101596 : SMCHD 1 : chrl ENSG00000129103:SUMF2:chr7:+: :99716018:99716272:99711891:9971682 8:+:2750040:2750120:2747645:275 56142278:56142429:56136331:5614 6 0347 4526

ENSG00000175198:PCCA:chrl3:+: ENSG00000234127:TRIM26:chr6:-

ENSG00000105357:MYH14:chrl9:+:50 100962086:100962162:100925600:1 :30172432:30172542:30168915:301

727410:50727434:50726606:50728841 00982814 81081

ENSG00000139631:CSAD:chrl2:- ENSG00000165238:WNK2:chr9:+:

ENSG00000168763:CNNM3:chr2:+:974 :53565056:53565225:53564286:535 96018580:96018736:96015364:9601 97705:97497805:97494871:97498288 67128 9229 ENSG00000120071 :KANSL 1 :chrl7: - ENSG00000125347:IRFl:chr5:- ENSG00000091428:RAPGEF4:chr2 :44110768:44110826:44109665:4411152 : 131825083: 131825175: 131822822: :+: 173825487: 173825541: 17378702 6 131826236 8:173825849

ENSG00000143537:ADAM15:chrl:+:15 ENSG00000182979:MTAl:chrl4:+: ENSG00000081803:CADPS2:chr7:-

5034379:155034451:155033965:155034 105933043:105933079:105932915:1 : 122019421: 122019496: 121985735:

720 05935803 122027079

ENSG00000114867 :EIF4G1 :chr3 :+: 184 ENSG00000181163 :NPM1 :chr5 :+: 1 033919:184034006:184033644:1840355 70818308:170818428:170815010:17 ENSG00000169026:MFSD7:chr4:- 04 0832305 :678271 :678391 :677550:678507 ENSG00000161265:U2AFlL4:chrl

ENSG00000139624:CERS5:chrl2:- 9:-

ENSG00000137959:IFI44L:chrl:+:7909 :50526744:50527851:50524477:505 :36235526:36235593:36235322:362 5404:79095600:79086256:79101021 28328 36248 ENSG00000125458:NT5C:chrl7:- ENSG00000152520:PAN3:chrl3:+: ENSGOOOOO 163138:PACRGL :chr4 : :73127059:73127200:73126962:7312727 28846117:28846208:28845003:2885 +:20703763:20703844:20702410:20 5 1373 706088

ENSG00000196781:TLEl:chr9:- ENSG00000144935:TRPCl:chr3:+:

ENSG00000007376:RPUSDl:chrl6:- :84267098 : 84267203 : 84249216 :843 142503545:142503882:142467302:1 :837067:837179:836928:837353 00590 42509860 ENSG00000151923:TIALl:chrl0:- ENSG00000100099:HPS4:chr22:- : 121339982: 121340358: 121339522: 1213 ENSG00000103227:LMFl:chrl6:- :26862016:26862070:26861517:268 41433 :983990:984145:961079:984243 62191

ENSG00000163864:NMNAT3:chr3:

ENSG00000011347: SYT7 :chrl 1 : - ENSG00000197343:ZNF655:chr7:+ :61313502:61313727:61300596:6132357 :99159510:99160117:99158318:991 : 139356804: 139356904: 139346606:

5 61485 139396546

ENSG00000149294:NCAM1 :chrl 1 :

ENSG00000142459:EVI5L:chrl9:+:792 ENSG00000161328:LRRC56:chrll: +: 113092017: 113092047: 113085233 1977:7922010:7920954:7923076 +:552568:552702:551967:553962 : 113102366 ENSG00000076043 :REX02 :chrl 1 :+: 11 ENSG00000187742:SECISBP2:chr9 4314577:114314655:114311461:114316 ENSG00000125875:TBClD20:chr2 :+:91954778:91954868:91953495:9 700 0:-:428532:428718:425774:442979 1956261

ENSG00000122085:MTERF4:chr2: ENSGOOOOO 102710 : SUPT20H :chrl

ENSG00000203875 : SNHG5 :chr6 :- 3:-

:86387141:86387210:86375865:8638785 :242033691:242033844:242029459: :37584688:37584792:37583946:375

3 242041667 86328

ENSG00000178965:ERICH3:chrl:-

ENSG00000006282:SPATA20:chrl7:+:4 ENSG00000082805:ERCl:chrl2:+: :75107014:75107143:75102122:751 8625025 :48625128:48624646:48625643 1372199:1372331:1346070:1399017 08710 ENSG00000120049 :KCNIP2 : chrl 0 : - ENSG00000152578:GRIA4:chrll:+ ENSG00000182578:CSFlR:chr5:- : 103588145: 103588216: 103587750: 1035 : 105816189: 105816228: 105804695: : 149465941 : 149466170: 149460587: 88383 105836673 149492823

ENSG00000226210:ABC7- ENSG00000001167:NFYA:chr6:+:4 ENSGOOOOO 129696 :TTI2 :chr8 : -

42389800N19.1:chrl2:+:88256:88392:87 1048549:41048636:41046903:41051 :33364746:33364839:33361453:333

703:88569 784 67263

ENSG00000141699:FAM134C:chrl

ENSGOOOOOO 10803 :SCMH1 :chrl :- ENSG00000065882:TBClDl:chr4: 7:- :41625396:41625605:41618413:4162654 +:38062240:38062279:38055959:38 :40739851:40739882:40738909:407

6 091552 44073 ENSG00000185787:MORF4Ll:chr ENSG00000205726:ITSN1 :chr21 :+:

ENSG00000133030:MPRIP:chrl7:+:170 15:+:79170554:79170601:79165399 35195790:35195957:35191627:3519

67422:17071229:17064670:17075031 :79178482 9121

ENSG00000198563:DDX39B:chr6: ENSG00000075223 : SEMA3 C:chr7 :

ENSG00000176124:DLEUl:chrl3:+:506 :31508929:31509104:31508441:315 :80387646:80387804:80380652:803

57277:50657330:50656693:50678839 09726 90931

ENSG00000147010:SH3KBPl:chr

X:-

ENSG00000157450:RNFlll:chrl5:+:59 : 19705734: 19705809: 19702146: 197 ENSG00000161328:LRRC56:chrll:

376300:59376453:59373483:59377857 13112 +:552089:552232:551967:553962 ENSG00000095637:SORBSl:chrl0:

ENSG00000151150:ANK3:chrl0:-

ENSG00000215039:CD27-ASl:chrl2:- :61905725:61905779:61898845:619 : 97146747 :97146876 :97144042 : 971

:6559506:6560146:6557903:6560634 26581 56976

ENSG00000105655:ISYNAl:chrl9:

ENSG00000253352:TUGl:chr22:+:

ENSG00000112763 :BTN2A1 :chr6:+:26 : 18547782: 18547915: 18547687: 185 31368033:31368158:31367765:3136 463024:26463125:26460056:26463471 48669 8840

ENSG00000204681 : GABBRl :chr6 :

ENSG00000234741 :GAS5 :chrl :- ENSG00000176473:WDR25:chrl4: : 173835898: 173835934: 173835344: 1738 +:100847246: 100848083 : 10084284 :29596863 :29597024:29595423 :295 36128 1:100934357 99172

ENSG00000176261:ZBTB80S:chrl

ENSG00000147996:CBWD5:chr9:-

ENSG00000147905 :ZCCHC7 :chr9 :+: 37 :33097427:33097480:33093145:331 :70465707:70465794:70463075:704 349353:37349449:37327831:37356831 00368 67483

ENSG00000204209 :D AXX:chr6 :-

ENSG00000186231 :KLHL32 :chr6 :+: 975 :33288512:33289344:33288368:332 ENSG00000108515:EN03:chrl7:+: 61658:97562385:97533217:97575279 90638 4856345:4856404:4856185:4856566

ENSG00000004534:RBM6:chr3:+:5 ENSG00000091129:NRCAM:chr7:-

ENSG00000170634 : ACYP2 :chr2 :+: 5427 0036872:50036946:50000118:50085 : 107831697: 107831727: 107825058: 8094:54278187:54200947:54284375 677 107832172 ENSG00000146232:NFKBIE:chr6:- ENSG00000011143:MKSl:chrl7:- :44229362:44229585:44228276:4423271 ENSG00000162004:CCDC78:chrl6 :56283825:56283908:56283741:562 8 :-:775445:775580:775293:775793 85254

ENSG00000239922:RP11- ENSG00000050405:LIMAl:chrl2:- ENSG00000214078:CPNEl:chr20:-

71N10.1 :chr3 :+: 147658345 : 147658406: 1 :50579172:50579231:50575820:505 :34246851:34246936:34220845:342

47657903:147713541 86234 52723

ENSG00000214706:IFRD2:chr3:- ENSG00000179902:Clorfl94:chrl>

ENSG00000109685:NSD2:chr4:+: 19401 :50326877:50327059:50326368:503 : 109649628: 109649744: 109649281 : 77:1940259:1936989:1952798 27142 109656254

ENSG00000148341:SH3GLB2:chr9

ENSG00000164941:INTS8:chr8:+:9

ENSG00000176720:BOK:chr2:+:242498 : 131774514: 131774577: 131772972: 5880919:95881041:95879565:95884

869:242499118:242498408:242509539 131776689 111

ENSG00000070501:POLB:chr8:+:4 ENSGOOOOOH1481:COPZl:chrl2:+

ENSG00000135164:DMTFl:chr7:+:867 2196529:42196587:42196203:42202 :54734330:54734399:54718965:547 92554:86792648:86781871:86792810 470 41550 ENSG00000118518:RNF146:chr6:+:127 ENSG00000110218:PANX1 :chrl 1 : ENSG00000204099 :NEU4 :chr2 :+:2 606352: 127606493 : 127601485 : 1276077 +:93886656:93886796:93862659:93 42754470:242754651 :242752556:24 60 911534 2755678

ENSG00000164808:SPIDR:chr8:+: ENSG00000137573:SULFl:chr8:+:

ENSG00000133226:SRRMl:chrl:+:249 48639761 :48639855:48626203 :4864 70550736:70550879:70541914:7055

89673:24989715:24989295:24993305 7868 0969

ENSG00000137871:ZNF280D:chrl ENSG00000204536:CCHCRl:chr6:

5:-

ENSG00000134780:DAGLA:chrll:+:61 :56974451:56974675:56971019:569 :31117842:31117992:31116505:311

503032:61503116:61502474:61503210 81238 18231

ENSG00000122481 :RWDD3 :chrl :+ ENSG00000100505:TRIM9:chrl4:-

ENSG00000080603:SRCAP:chrl6:+:307 :95709766:95710254:95699871:957 :51452673:51452862:51448821:514

33883:30734069:30733607:30734283 12311 64767

ENSG00000154743:TSEN2:chr3:+: ENSG00000115290:GRB14:chr2:-

ENSG00000164619:BMPER:chr7:+:340 12560557:12560696:12546730:1257 : 165350940: 165351034: 165349692:

85917:34086017:34014396:34091472 0386 165353517 ENSG00000163644:PPMlK:chr4:- ENSG00000121905:HPCA:chrl:+:3

ENSG00000108175:ZMIZl:chrl0:+:810 :89199687:89199794:89198395:892 3354478:33354877:33352116:33359

70680:81070941:81067328:81072398 05557 124

ENSG00000137478:FCHSD2:chrll

ENSG00000031003 :FAM13B :chr5 :- ENSG00000169231 :THBS3 xhrl :- : 137292165: 137292231:137290065: 1372 : 155170884: 155170995: 155170795: :72611301:72611373:72600990:726 95304 155171207 13587

ENSG00000080947:CROCCP3:chr ENSG00000080822: CLDND 1 :chr3 :

1:-

ENSG00000075407:ZNF37A:chrl0:+:38 : 16802893 : 16802999: 16802557: 168 :98240496:98240547:98240221:982

383858:38384152:38383418:38384465 03424 41692

ENSG00000240240:RP11- ENSG00000132716:DCAF8:chrl:- ENSG00000230124:ACBD6:chrl:-

146D12.2:chr9:+:42436766:42436937:42 : 160231074: 160231148: 160213824: : 180461403: 180461500: 180399397:

435225:42473935 160231906 180471179

ENSG00000004455:AK2:chrl:- ENSG00000142192 : APP : chr21 : - ENSG00000141644:MBDl:chrl8:-

:33497144:33497262:33490168:3350233 :27369674:27369731:27354790:273 : 47800555 :47800723 :47800233 :478

6 94155 01346

ENSG00000088854:C20orfl94:chr2

ENSG00000113240 : CLK4 :chr5 : - ENSG00000135596:MICALl:chr6:- 0:- : 178046838: 178047674: 178045779: 1780 : 109769077 : 109769166 : 109768925 : :3324322:3324378:3321286:334016 49393 109769934 2

ENSG00000158234:FAIM:chr3:+:l ENSG00000158106:RHPNl:chr8:+:

ENSG00000188732:FAM221A:chr7:+:2 38338552:138338612:138327779:13 144462231:144462345:144461678:1

3737810:23737918:23731215:23740404 8340248 44462758

ENSG00000198689:SLC9A6:chrX:+:13 ENSG00000197892:KIF13B:chr8:- ENSG00000147526:TACCl:chr8:+:

5084266:135084372:135081127:135092 :28932797:28932860:28929833:289 38681507:38681543:38678153:3868

600 50261 2825

ENSG00000132478:UNK:chrl7:+:7 ENSG00000148688:RPP30:chrl0:+:

ENSG00000164916:FOXKl:chr7:+:478 3788393:73788559:73788100:73789 92662948:92663033:92660425:9266

0468:4780654:4722499:4794089 523 5058

ENSG00000076826:CAMSAP3:chr ENSG00000099998:GGT5:chr22:-

ENSG00000250305:KIAA1456:chr8:+:l 19:+:7671662:7671695:7671457:76 :24621212:24621382:24621074:246

2863710:12863865:12848540:12870192 73011 21513

ENSG00000129467:ADCY4:chrl4:

ENSG00000152042 :NBPF 11 : chr 1 : - ENSG00000142920:AZIN2:chrl:+: : 146053225: 146053298: 146052763: 1460 :24790921:24791182:24789094:247 33548663:33548743:33547955:3354 54298 91271 9554

ENSG00000165475:CRYLl:chrl3:- ENSG00000175224:ATG13:chrll:+

ENSG00000072518:MARK2:chrll:+:63 :21013731:21013893:21006435:210 :46651594:46651650:46639925:466

673559:63673586:63672515:63676348 63508 65828

ENSG00000148482:SLC39A12:chrl0:+: ENSG00000215915:ATAD3C:chrl: ENSG00000087157:PGSl:chrl7:+:7

18282109:18282220:18280232:1828458 +: 1389724: 1389880: 1387814: 13908 6410959:76411108:76400170:76415

4 39 626

ENSG00000101246 : ARFRP 1 : chr20 :

ENSG00000077782 :FGFR1 :chr8 :-

ENSG00000091536:MY015A:chrl7:+:l :38286764:38286908:38285953:383 :62333181:62333250:62332054:623

8069674:18069835:18067152:18070903 14873 33487

ENSG00000079332:SARlA:chrl0:- ENSG00000204650 :LINC02210 :chr ENSG00000136874:STX17:chr9:+:

:71921613:71921687:71920825:7193016 17:+:43712666:43712764:43707524 102722198:102722314:102713567:1

8 :43713648 02722386

ENSG00000136754:ABIl:chrl0:- ENSG00000258984:UBE2F- ENSG00000116106 :EPHA4:chr2:-

:27044583:27044670:27040712:2705414 SCLY:chr2:+:238896604:23889663 :222321332:222321492:222310901:

6 4:238881867:238925207 222322585

ENSG00000143952:VPS54:chr2:- ENSG00000243943 :ZNF512 :chr2 :+

ENSG00000068724 :TTC7 A:chr2 :+:4718 :64208779:64209021:64199378:642 :27806524:27806583:27806009:278 5633:47185691:47184146:47202111 10997 20933

ENSG00000005801 :ZNF195 :chrl 1 :

ENSG00000128563:PRKRIPl:chr7:

ENSG00000124920:MYRF:chrll:+:615 +: 102006401 : 102006523 : 10200485 :3382972:3383119:3381795:339217

48183:61548264:61547762:61548431 8:102016269 2

ENSG00000113649:TCERGl:chr5:+:14 ENSG00000131748:STARD3:chrl7 ENSG00000144283:PKP4:chr2:+:15

5847903:145847966:145843356:145849 :+:37814961:37815073:37814775:3 9389949:159390046:159389828:159

106 7815303 459581

ENSG00000140688:C16orf58:chrl6

ENSG00000205726:ITSN1 :chr21 :+:

ENSG00000108509:CAMTA2:chrl7:- :31504298:31504369:31503661:315 35174733:35174748:35172233:3518 :4885383:4885470:4885126:4886051 04923 3278 ENSG00000132589:FLOT2:chrl7:- ENSG00000160570:DEDD2:chrl9:- ENSG00000143612:Clorf43:chrl:-

:27212874:27212965:27210249:2722454 :42720831:42721197:42719404:427 : 154192311: 154192413: 154187050:

3 24225 154192817

ENSG00000141837:CACNAlA:chr ENSG00000142856:ITGB3BP:chrl:

19:-

ENSG00000132024:CC2DlA:chrl9:+:l : 13339512: 13339609: 13335586: 133 :63913235:63913285:63912527:639

4030630:14030764:14030015:14031369 40895 19588

ENSG00000114978 :MOBlA:chr2:- ENSGOOOOO 151092 :NGLY1 :chr3 :-

ENSG00000113460 :BRIXl:chr5:+:3491 :74405241 :74405408:74399879:744 :25761620:25761682:25761126:257

9944:34919988:34916002:34922321 05787 70623

ENSG00000132122:SPATA6:chrl:- ENSG00000119844:AFTPH:chr2:+: ENSG00000006283 : CACNA1 G:chr

:48771458:48771550:48764565:4882134 64808323:64808407:64800202:6481 17:+:48672353:48672422:48669453

1 2555 :48673922

ENSG00000135905:DOCK10:chr2:- ENSG00000006194 :ZNF263 :chrl6 : ENSGOOOOO 150672 :DLG2:chrl 1 : -

:225657690:225657789:225653887:2256 +:3335680:3335754:3334205:33360 :83194295:83194341:83183820:832

58116 22 43750

ENSG00000138698:RAPlGDSl:ch ENSG00000118518:RNF146:chr6:+

ENSG00000152219:ARL14EP:chrll:+:3 r4:+:99300167:99300314:99273752: : 127603431 : 127603540: 127601749:

0352432:30352921:30344749:30354412 99313102 127607194

ENSG00000095637:SORBSl:chrl0 ENSG00000069275 :NUCKS 1 xhrl :

ENSG00000145014:TMEM44:chr3:- : 194336297: 194336399: 194331749: 1943 :97154757:97154832:97144042:971 :205698699:205698749:205689781: 43952 56976 205719084

ENSG00000157087:ATP2B2:chr3:-

ENSG00000103037:SETD6:chrl6:+:585 ENSG00000150995 :ITPR1 :chr3 :+:4 : 10373666: 10373721: 10370809: 103

51954:58552135:58550832:58552304 759050:4759083:4753552:4767229 77812

ENSG00000169696:ASPSCRl:chrl ENSG00000122085:MTERF4:chr2:-

ENSG00000168502:MTCLl:chrl8:+:88 7:+:79952696:79952754:79943483: :242033691:242033847:242029459:

28905:8828962:8826230:8831604 79966912 242036657

ENSG00000073712:FERMT2:chrl4 ENSG00000167550:RHEBLl:chrl2

ENSG00000213614 :HEXA: chrl 5 : - :72646031 :72646078:72643575:7264789 :53348513:53348546:53348187:533 :49460750:49460818:49460484:494 9 60010 62817

ENSGOOOOO 171204 : TMEM126B : ch ENSGOOOOO 183696 :UPP1 :chr7 :+:48

ENSG00000182903:ZNF721:chr4:- rll:+:85342188:85342360:8533973 142893:48143008:48141579:481464

:429558:429668:420908:431234 2:85345129 69

ENSG00000121310:ECHDC2:chrl: ENSG00000121310:ECHDC2:chrl:

ENSG00000110200:ANAPC15:chrll:-

:71822487:71822542:71822332:7182369 :53370705:53372283:53370505:533 :53370705:53370762:53370505:533

5 73539 73539

ENSG00000175061 :LRRC75A- ENSG00000232527:RP11-

ENSG00000171298:GAA:chrl7:+:78075 ASl:chrl7:+: 16342841: 16343017:1 14N7.2:chrl:+: 148933290: 14893336

609:78075724:78075424:78078353 6342728:16343424 8:148932920:148951244

ENSG00000240225:ZNF542P:chrl ENSG00000160679:CHTOP:chrl:+:

ENSG00000102385:DRP2:chrX:+: 10049 9:+:56880647:56880706:56880305: 153615702:153615840:153610924:1 7892: 100497971 : 100497460: 100500005 56884525 53617539 ENSG00000175727:MLXIP:chrl2:+:122 ENSG00000151657:KIN:chrl0:- ENSG00000112851:ERBIN:chr5:+: 616838:122616930:122615480:1226178 :7825043:7825138:7822270:782978 65364704:65364848:65350779:6536 94 2 7996

ENSG00000198742 : SMURF1 :chr7 :

ENSG00000168803:ADAL:chrl5:+:

ENSG00000105662:CRTCl:chrl9:+:188 :98648537:98648615:98647332:986 43639213:43639294:43638178:4364 85709: 18885796: 18879603 :18886450 48979 1104 ENSG00000107164:FUBP3:chr9:+:1334 ENSG00000178209:PLEC:chr8:- ENSG00000085733 :CTTN:chrl 1 :+: 89674:133489732:133488414:13349174 : 144996671 : 145000052: 144996563 : 70269045:70269101:70265962:7027 1 145000951 5156

ENSG00000108423 :TUBD 1 :chrl7: - ENSG00000078674:PCMl:chr8:+:l ENSG00000137210:TMEM14B:chr :57943969:57944110:57941208:5795189 7838099:17838264:17830196:17842 6:+: 10749434: 10749501: 10748114: 9 955 10755374

ENSGOOOOO 163660 : CCNL 1 : chr3 : - ENSG00000141644:MBDl:chrl8:-

ENSG00000154743:TSEN2:chr3:+:1254 : 156867075: 156867174: 156866378: : 47800555:47800720:47800233 :478

6652:12546730:12545283:12558109 156867273 01346

ENSG00000204152 :TIMM23B :chrl ENSG00000089248:ERP29:chrl2:+:

ENSG00000139974:SLC38A6:chrl4:+:6 0:+:51384298:51384357:51381846: 112457559:112457698:112451413:1

1510167:61510221:61497241:61512063 51387652 12459953 ENSG00000117385 :P3H1 :chrl :- ENSGOOOOO 116754 :SRSF11 :chrl :+:

ENSG00000126091:ST3GAL3:chrl:+:4 :43222071:43222126:43221308:432 70696777:70696886:70694238:7069

4363906:44363970:44360149:44395803 23453 7541

ENSG00000093167:LRRFIP2:chr3:

ENSG00000165495 :PKNOX2:chrl 1 :+: 1 ENSG00000068745:IP6K2:chr3:- 25281641:125281761:125267958:12529 :48732134:48732257:48731673 :487 :37114280:37114373:37107816:371 8907 32522 16514

ENSG00000167110:GOLGA2:chr9:

ENSG00000128581:IFT22:chr7:- ENSG00000055955:ITIH4:chr3:- : 100962236: 100962313 : 100959823 : 1009 :52852067:52852184:52851074:528 : 131029472: 131029553 : 131028604: 64951 52272 131029736

ENSG00000073921 :PICALM:chrl 1

ENSG00000140416:TPMl:chrl5:+:

ENSG00000158321:AUTS2:chr7:+:7023 63356262:63356341:63354844:6335 :85671717:85671820:85670103:856

3009:70233054:70231320:70242088 8094 92171

ENSG00000226210:ABC7- ENSG00000070081 :NUCB2:chrl 1 :

42389800N19.1:chrl2:+:88256:88392:88 +: 17336932: 17337022: 17333667: 17 ENSG00000130731:METTL26:chrl

017:88569 351673 6:-:685517:685774:685340:686093

ENSG00000154114:TBCEL:chrll: ENSG00000219545:UMADl:chr7:+

ENSG00000161956:SENP3:chrl7:+:746 +:120924338: 120924441 : 12091837 :7907960:7908239:7841374:791691 9011 :7469081 :7468904:7470243 6:120925760 1 ENSG00000099998:GGT5:chr22:- ENSGOOOOO 198276 :UCKL 1 :chr20: - :24616459:24616552:24616084:2462096 ENSG00000214021 :TTLL3 :chr3 :+: :62575005:62575022:62572561:625 3 9857757:9857886:9855029:9862229 75749 ENSG00000251322: SHANK3 :chr2 ENSGOOOOO 183696 :UPP1 :chr7 :+:48

ENSG00000163806 : SPDYA:chr2 :+:290 2:+:51150042:51150066:51144580: 141420:48141467:48134424:481464

11523:29011675:29006844:29022064 51153344 69

ENSG00000132846:ZBED3:chr5:- ENSGOOOOO 124074 :ENKD 1 : chrl 6 : - ENSG00000204842 : ATXN2 :chrl2: -

:76374418:76374553:76373720:7638293 :67698898:67699071:67697459:676 : 111891480: 111891649: 111890644:

5 99973 111893832

ENSG00000077454 :LRCH4:chr7 : - ENSG00000073417:PDE8A:chrl5:+

ENSG00000145362:ANK2:chr4:+: 11427 : 100174708: 100174777: 100174628: :85619963:85620018:85610435:856 4200: 114280455: 114271405:114281978 100175119 26786 ENSG00000160741 : CRTC2 :chrl : - ENSG00000166897:ELFN2:chr22:- ENSG00000135298:ADGRB3:chr6: : 153927540: 153927642: 153927465: 1539 :37813807:37813958:37772036:378 +:69646410:69646572:69349324:69 30820 23332 653721

ENSGOOOOO 100445 : SDR39U 1 :chrl 4:-

ENSG00000133816:MICAL2:chrll:+:l ENSG00000056998:GYG2:chrX:+: :24911383:24911466:24911001:249

2262586:12262709:12261132:12277189 2793850:2793955:2779763:2799092 11551

ENSG00000105341:ATP5SL:chrl9:

ENSG00000095637:SORBSl:chrl0:- ENSG00000205464:ATP6APlL:chr :97115383:97116862:97114724:9711738 :41942296:41942377:41939578:419 5:+:81600752:81601300:81600669: 7 45786 81605975

ENSG00000141580:WDR45B:chrl7:- ENSG00000272886:DCPlA:chr3:- ENSG00000032219:ARID4A:chrl4:

:80588796:80588898:80579675:8060182 :53338206:53338320:53326857:533 +:58832741:58832786:58832340:58

4 46270 833600

ENSG00000133627 : ACTR3B :chr7 :+: 15 ENSG00000272647 :GS 1 - ENSG00000141376:BCAS3:chrl7:+ 2497615:152497740:152457011:152498 259H13.13:chr7:+:99202008:99202 :59465978:59466069:59457932:594 705 219:99197908:99204370 69337

ENSG00000196295:AC005154.6:chr7:- ENSG00000107371:EXOSC3:chr9:- ENSGOOOOO 104852: SNRNP70 :chrl :30590933:30591011:30590397:3060108 :37781982:37782134:37780877:377 9:+:49605370:49606844:49604728:

1 83910 49607890

ENSG00000112031 :MTRFlL:chr6:

ENSG00000140365:COMMD4:chrl5:+: ENSG00000140416:TPMl:chrl5:+:

75630695:75630761:75630474:7563098 : 153312319: 153312456: 153311230: 63353396:63353472:63353138:6335

6 153313991 3911

ENSG00000166797:FAM96A:chrl5

ENSG00000088298:EDEM2:chr20:- ENSG00000121940:CLCCl:chrl:-

:33719444:33719586:33714178:3372568 : 109504930: 109505091: 109493070: :64373300:64373350:64367736:643

2 109505982 80885

ENSG00000149089:APIP:chrll:- ENSG00000169169:CPTlC:chrl9:+ ENSG00000081803:CADPS2:chr7:-

:34916556:34916657:34912099:3493777 :50195077:50195146:50194597:501 : 122076413: 122076434: 122056218:

4 95495 122078394

ENSG00000184313 :MR0H7:chrl :+ ENSG00000133961:NUMB:chrl4:-

ENSG00000134283:PPHLNl:chrl2:+:42 :55145563:55145718:55144527:551 :73876644:73876776:73833689:739

778741:42778798:42749024:42781257 48328 25198 ENSG00000151006:PRSS53:chrl6: ENSG00000089060 : SLC8B 1 :chrl2 :

ENSG00000132639: SNAP25 :chr20 :+: 10 :31096100:31096345:31096024:310 : 113772247: 113772640: 113770765: 265371:10265420:10258374:10286776 96430 113772797

ENSGOOOOO 140400 :M AN2C 1 : chrl

ENSG00000100425 :BRD 1 :chr22: - 5:- ENSG00000042429 :MED 17 :chrl 1 :

:50181037:50181170:50171461:5018768 :75656339:75656529:75655089:756 +:93530700:93530885:93529706:93

1 56828 535000

ENSG00000163531 :NFASC:chrl :+:204 ENSG00000179950:PUF60:chr8:- ENSG00000125149:C16orf70:chrl6 931235:204931286:204926954:2049373 : 144906482: 144906569: 144904083 : :+:67159861:67159945:67154097:6 76 144911449 7168070

ENSGOOOOO 106771 : TMEM245: chr

ENSG00000205336:ADGRGl:chrl 9:-

ENSG00000109180 :OCIAD 1 :chr4 :+:488 6:+:57675502:57675620:57673582: : 111848276: 111848300: 111843223 : 59229:48859382:48853992:48862741 57684164 111849452

ENSGOOOOO 182389: CACNB4 :chr2 :

ENSG00000100325:ASCC2:chr22:-

ENSG00000072736:NFATC3:chrl6:+:6 :30228233:30228331:30221769:302 : 152698181: 152698253: 152695893: 8248231 :68248335:68225678:68260252 34166 152698416

ENSG00000167549:COR06:chrl7:- ENSG00000250222:CTC-

ENSG00000149761:NUDT22:chrll:+:6 :27946668:27946791:27945989:279 338M12.5:chr5:+: 180620341: 18062 3995039:63995138:63994604:63996949 48241 0467:180619140:180621233 ENSG00000179912:R3HDM2:chrl2:- ENSG00000158545:ZC3H18:chrl6: ENSG00000170791:CHCHD7:chr8: : 57682791:57682823:57677839: 5768635 +:88691609:88691675:88691153:88 +:57125320:57125468:57124396:57 4 695165 127156

ENSG00000213463:SYNJ2BP:chrl

ENSG00000135749 :PCNX2 :chrl :- 4:- ENSGOOOOO 134769 :DTNA:chrl 8 :+: :233362971:233363117:233353930:2333 :70855186:70855323:70842488:708 32418708:32418801:32418135:3242 72590 83616 8259

ENSGOOOOO 135525 :M AP7 : chr6 : - ENSGOOOOO 160948 : VPS28 :chr8 : -

ENSG00000022267 :FHL 1 :chrX:+: 13529 : 136846969: 136847109: 136742937: : 145650328: 145650383: 145649651: 1401:135291601:135290800:135292029 136847499 145651065

ENSG00000172824:CES4A:chrl6:+ ENSG00000130396:AFDN:chr6:+:l

ENSG00000130731 :METTL26 : chr 16 : - :67040647:67040720:67038127 :670 68294541:168294586:168291709:16 :684888:685063:684797:686093 42876 8297557 ENSGOOOOO 160613 :PCSK7:chrl 1 : - ENSG00000196498 :NCOR2:chrl2 : - : 117078369 : 117078451 : 117077876 : 1170 : 124825147 : 124825240 : 124824989 : ENSG00000172785:CBWDl:chr9:- 78685 124826368 : 154708: 154795: 152078: 156480

ENSGOOOOO 100413 :P0LR3H :chr22 : - ENSGOOOOO 158458 :NRG2 : chr5 : - ENSG00000122008:POLK:chr5:+:7

:41929525:41929691:41928749:4193999 : 139239473: 139239497: 139235363: 4889790:74889874:74882883:74892

4 139244699 046

ENSG00000072182 : ASIC4 :chr2:+:2203 ENSG00000118518:RNF146:chr6:+ 96479 :220396624 :220380028:22039989 : 127603431 : 127603540: 127601485 : ENSG00000172366:MCRIP2:chrl6: 2 127607194 +:696471:696608:692249:697782

ENSG00000115307:AUPl:chr2:- ENSG00000000457 : SCYL3 xhrl :- ENSG00000006740 : ARHGAP44 : ch :74755543:74755616:74755133:7475587 : 169833509: 169833649: 169831938: rl7:+: 12799723: 12799828: 1269320 7 169836036 8:12812213

ENSG00000127527 :EPS 15L 1 :chrl 9 ENSG00000138617:PARP16:chrl5:

ENSG00000168256:NKIRAS2:chrl7:+:

40174587:40174658:40174490:4017567 : 16472589: 16472795: 16466662: 164 :65563272:65563410:65559106:655

1 87932 78590

ENSG00000088448:ANKRD10:chr

ENSG00000002016 :RAD52 :chrl2 :- 13:-

ENSG00000143252:SDHC:chrl:+: 16129 : 1023576: 1023698: 1023287: 102550 : 111552876: 111553008: 111545610: 3403:161293460:161284215:161309351 9 111558379

ENSG00000120685:PROSERl:chrl

3:- ENSGOOOOO 132781 :MUTYH:chrl : -

ENSG00000136280:CCM2:chr7:+:4510 :39603417:39603512:39602457:396 :45799084:45799266:45798996:458 4061:45104245:45039962:45112324 05699 00062 ENSG00000160293:VAV2:chr9:- ENSG00000197111 :PCBP2 :chrl2 :+ ENSG00000143390:RFX5:chrl:- : 136634538: 136634625: 136633718: 1366 :53861588:53861627:53861077:538 : 151318403: 151318433: 151317664: 35499 62560 151318680

ENSGOOOOO 168476 :REEP4 :chr8: - ENSG00000114841 :DNAHl:chr3:+ ENSG00000108433:GOSR2:chrl7: :21996438:21996574:21996306:2199692 :52412617:52412796:52410009:524 +:45012394:45012591:45009565:45 8 13920 015964 ENSG00000005961:ITGA2B:chrl7:

ENSG00000196440 : ARMCX4 :chrX:+: 1 ENSG00000109184:DCUNlD4:chr 00741009: 100741079: 100673988: 10074 :42451721:42451838:42449791:424 4:+:52775085:52775141:52765544: 2179 52365 52777235

ENSG00000266967: AARSD 1 :chrl7: - ENSG00000163125 :RPRD2:chrl :+: ENSG00000073536:NLEl:chrl7:- :41105740:41105795:41103911:4110689 150437002:150437203:150432793:1 :33464561:33464659:33464212:334 2 50443036 64832

ENSG00000124222:STX16:chr20:+ ENSGOOOOO 144406 :UNC80 :chr2 :+:

ENSG00000171729:TMEM51:chrl:+:15 :57244357:57244509:57243183:572 210849579:210849636:210847041:2

541390:15541927:15480450:15545821 45567 10856889

ENSG00000102882:MAPK3:chrl6:

ENSG00000061938:TNK2:chr3:- ENSG00000167889:MGAT5B:chrl : 195609156: 195609199: 195606046: 1956 :30128457:30128606:30128324:301 7:+:74921047:74921179:74902269: 10027 28990 74934069

ENSG00000077254:USP33:chrl:- ENSGOOOOO 118762 :PKD2 :chr4 :+: 8

ENSG00000131149:GSEl:chrl6:+:8569 :78181426:78181553:78178966:781 8979134:88979255:88977419:88983

8620:85698734:85697220:85699581 83551 057

ENSG00000100105:PATZl:chr22:- ENSG00000162341:TPCN2:chrll:+

ENSG00000196218:RYRl:chrl9:+:3906 :31724772:31724845:31723295:317 :68822188:68822265:68821565:688

1246:39061333:39058557:39062658 31677 22642

ENSG00000106624:AEBPl:chr7:+: ENSG00000124222:STX16:chr20:+

ENSG00000137449:CPEB2:chr4:+:1504 44149255:44149723:44148940:4414 :57244346:57244509:57243183:572 2087: 15042111 : 15034835 : 15054037 9805 45567 ENSG00000186472:PCLO:chr7:- ENSG00000173210:ABLIM3:chr5: ENSG00000132780:NASP:chrl:+:4 :82464982:82465009:82457282:8246753 +:148622053 : 148622101 : 14861945 6072992:46074009:46072263:46078

3 1:148624443 840

ENSG00000148803:FUOM:chrl0:- ENSG00000156709:AIFMl:chrX:-

ENSG00000170049:KCNAB3:chrl7:- : 135170690: 135170759: 135170517: : 129290434: 129290577: 129289261 : :7826773 :7826862:7826497:7827028 135171426 129299524

ENSG00000163531 :NFASC:chrl :+: ENSG00000132541:RIDA:chr8:-

ENSG00000135722:FBXL8:chrl6:+:671 204971723:204971876:204957934:2 :99120873:99120996:99118554:991

97414:67197755:67195840:67197921 04978684 29259

ENSG00000128805:ARHGAP22:ch

ENSG00000130396:AFDN:chr6:+:1683 rlO:- ENSG00000053254:FOXN3:chrl4:- 55137: 168355173 : 168352867: 16836311 :49687678:49687807:49667934:497 :89656730:89656793:89647150:897 2 63507 47293

ENSG00000130733 : YIPF2 :chrl 9:- ENSG00000181322 :NME9 : chr3 : - ENSG00000052126:PLEKHA5:chrl : 11038305: 11038392: 11036449: 1103847 : 138033173: 138033249: 138025322: 2:+: 19423121: 19423139: 19422819:

4 138038319 19427449

ENSG00000120549:KIAA1217:chrl0:+: ENSG00000134369:NAVl:chrl:+:2 ENSG00000224078:SNHG14:chrl5

24783428:24783533:24762989:2478407 01773616:201773625:201772842:20 :+:25247871:25248035:25246860:2

5 1777080 5264173

ENSG00000060656:PTPRU:chrl:+: ENSG00000231925 :TAPBP:chr6 :-

ENSG00000171612:SLC25A33:chrl:+:9 29616194:29616224:29611381:2961 :33281470:33281641:33281254:332

633403:9633470:9627419:9640011 8380 81781

ENSG00000081803 :CADPS2 :chr7 :- ENSGOOOOO 118985 :ELL2 :chr5 : -

ENSG00000151353:TMEM18:chr2:- : 122033249: 122033369: 122028792: :95255127:95255249:95249638:952

:675757:676238:675630:677288 122033494 78705

ENSG00000185347:C14orf80:chrl4 ENSG00000114209:PDCD10:chr3:-

ENSG00000156170 :NDUFAF6 :chr8 :+: 9 :+: 105962216: 105962423: 10595907 : 167443188: 167443261 : 167438061 : 6064401:96064458:96060786:96087860 1:105963693 167452593 ENSG00000076685 :NT5C2 :chrlO : - ENSG00000172530:BANP:chrl6:+: ENSG00000213983:APlG2:chrl4:- : 104860508: 104860700: 104859776: 1048 88008653:88008813:87985121:8801 :24035024:24035101:24034910:240 60801 4641 35272

ENSGOOOOO 148660: CAMK2G:chrl

ENSG00000112983:BRD8:chr5:- ENSG00000115419:GLS:chr2:+:19 0:- : 137499775: 137499822: 137499033: 1375 1784940:191784974:191775047:191 :75579289:75579375:75577312:755 00008 785749 81439

ENSG00000204622:HLA- ENSG00000138101:DTNB:chr2:- ENSG00000102312:PORCN:chrX:+

J:chr6:+:29977096:29977144:29976954: :25610157:25610247:25606758:256 :48371222:48371240:48371107:483

29977311 11070 72627

ENSGOOOOO 163625 : WDFY3 : chr4 : - ENSG00000050426 :LETMD 1 :chrl2

ENSG00000140939:NOL3:chrl6:+:6720 :85729486:85729570:85724620:857 :+:51451788:51451911:51450285:5

5054:67205360:67204477:67208064 31039 1453143

ENSG00000083223:ZCCHC6:chr9:- ENSG00000171793 :CTPS1 :chrl :+: ENSG00000122033:MTIF3:chrl3:-

:88933872:88933973:88932191:8893449 41473120:41473217:41471766:4147 :28015153:28015214:28014586:280

8 4330 19224 ENSG00000140299:BNIP2:chrl5:- ENSG00000135502:SLC26A10:chr ENSG00000139631:CSAD:chrl2:-

:59970946:59971033:59970286:5997179 12:+:58016569:58016717:58016424 :53565109:53565225:53564286:535

0 :58018282 67128

ENSG00000181264:TMEM136:chrll:+: ENSG00000088367:EPB41Ll:chr2 ENSG00000215717:TMEM167B:ch

120197830:120198349:120196077:1202 0:+:34761685:34761876:34680735: rl :+: 109635511 : 109635643 : 109633

00685 34763472 504:109637038

ENSG00000140859:KIFC3:chrl6:- ENSG00000025423:HSD17B6:chrl ENSG00000158560:DYNClIl:chr7:

:57793036:57793065:57792821:5779419 2:+:57157001:57157198:57146365: +:95431991:95432106:95402085:95

3 57167617 434032

ENSG00000137266 : SLC22A23 xhr

ENSG00000058404 :CAMK2B :chr7 : - ENSG00000031698: SARSxhrl :+: 1 6:- :44274237:44274278:44270653 :4428030 09779426:109779492:109778728:10 :3285169:3285193:3284209:328531 5 9779865 2

ENSG00000090006 :LTBP4 xhrl 9 :+ ENSG00000166377:ATP9B:chrl8:+

ENSG00000154328:NEIL2:chr8:+:1162 :41128854:41128926:41125398:411 :77132824:77132882:77119462:771 8954:11629094:11627300:11637106 29508 33897 ENSG00000072803 :FBXW11 :chr5 :- ENSG00000169169:CPTlC:chrl9:+ ENSG00000129255:MPDUl:chrl7: : 171384600: 171384702: 171341409: 1714 :50203940:50204112:50200722:502 +:7489268:7489396:7489115:74899 33461 04573 73

ENSG00000267120 : AD000671.6 :chrl 9 :- ENSG00000181555 : SETD2 : chr3 : - ENSG00000138286:FAM149Bl:chr :36230610:36230989:36230527:3623128 :47147486:47147610:47139571:471 10:+:74994950:74995076:74994698 0 55365 :74999069

ENSG00000162910:MRPL55:chrl:- ENSG00000117859:OSBPL9:chrl:+

ENSG00000147162:OGT:chrX:+:70764 :228296137:228296722:228296022: :52242504:52242590:52238395:522

416:70764485:70757922:70774362 228296961 46835

ENSG00000122203:KIAA1191:chr

ENSG00000089177:KIF16B:chr20:- ENSG00000162222:TTC9C:chrl 1 :+ 5:- : 16354901: 16355054: 16352406: 1635944 :62500589:62500671:62496558:625 : 175777615: 175777740: 175775359: 9 02853 175788604

ENSG00000244754 :N4BP2L2 :chrl 3 :- ENSG00000219626 :FAM228B :chr2

:33091993:33092140:33018263:3310990 :+:24360778:24360970:24358057:2 ENSGOOOOO 136295 :TTYH3:chr7:+:

5 4369617 2699573:2699674:2698649:2701301

ENSG00000130958:SLC35D2:chr9: ENSG00000164180:TMEM161B:ch

ENSG00000127483 :HP1BP3 xhrl :- r5:- :21106837:21107033:21106404:2111314 :99098998:99099066:99086451:991 :87493485:87493582:87492305:874 1 13384 94792

ENSG00000225190:PLEKHMl:chr

17:- ENSG00000197343:ZNF655:chr7:+

ENSG00000165102:HGSNAT:chr8:+:43 :43555170:43555513:43553092:435 :99160816:99160889:99158318:991

023086:43023204:43016650:43024315 59802 61485

ENSG00000092871:RFFL:chrl7:- ENSG00000250067:Y!EFN3:chrl9:

ENSG00000100744:GSKIP:chrl4:+:968 :33353392:33353580:33348800:334 +: 19640172: 19640322: 19639800: 19 46024:96846092:96829905:96848583 16123 643440 ENSG00000006283 : CACNA1 G:chrl7 :+ ENSGOOOOO 140157 :NIP A2 xhr 15 : - ENSG00000151914:DST:chr6:- :48687242:48687296:48685401:4869272 :23027800:23027922:23021429:230 :56329482:56329554:56328562:563 1 34120 30875

ENSG00000179988:PSTK:chrl0:+:1247 ENSG00000161791:FMNL3:chrl2:- 46384: 124746478: 124745891: 12474968 :50040421:50040536:50039686:500 ENSG00000101298:SNPH:chr20:+: 9 40668 1276968: 1277065 : 1247404: 1281205

ENSG00000101104:PABPClL:chr20:+: ENSG00000065559:MAP2K4:chrl7 ENSG00000160991:ORAI2:chr7:+:

43567314:43567389:43566832:4356776 :+: 11984672: 11984847: 11924318:1 102076648:102076780:102074108:1

6 1998891 02079390

ENSG00000186868:MAPT:chrl7:+: ENSG00000177302:TOP3A:chrl7:-

ENSG00000187953:PMS2CL:chr7:+:67 44067243 :44067441 : 44064461 :4406 : 18211664: 18211738: 18210280: 182

70264:6770358:6769932:6771527 8825 12195

ENSG00000121753:ADGRB2:chrl:

ENSG00000174938 : SEZ6L2 : chrl 6 : - ENSG00000165084:C8orf34:chr8:+: :29884025:29884064:29883847:2988456 :32193625:32193682:32193206:321 69380926:69381055:69358695:6940 0 93782 0257

ENSGOOOOO 111666 : CHPT 1 : chrl 2 :+ ENSG00000164896 :FASTK:chr7 :-

ENSG00000122958:VPS26A:chrl0:+:70 : 102113267: 102113294: 102110590: : 150773999: 150774114: 150773919:

915567:70915643:70892803:70916762 102113900 150774396

ENSG00000072121:ZFYVE26:chrl

ENSG00000187391:MAGI2:chr7:- 4:- ENSG00000180900 : SCRIB :chr8: -

:77694890:77694979:77649293:7770826 :68268795:68268999:68265339:682 : 144889721: 144889784: 144889183:

3 70817 144890778 ENSG00000144199:FAHD2B:chr2:

ENSG00000102383:ZDHHC15:chrX:- ENSG00000135446:CDK4:chrl2:-

:74725655:74725682:74698820:7474272 :58145282:58145479:58145125:581 :97757198:97757449:97751935:977

3 45957 60437

ENSG00000078967 :UBE2D4 :chr7 : ENSG00000172765 :TMCC1 :chr3 :-

ENSG00000138942:RNF185:chr22:+:31 +:43986757:43986828:43982630:43 : 129546645: 129546920: 129390107:

592921:31592976:31583256:31597483 988230 129551616

ENSG00000146067:FAM193B:chr5

ENSG00000095637:SORBSl:chrl0:- :97110972:97111133:97106209:9711463 ENSG00000197530:MIB2:chrl:+:l : 176974168: 176974229: 176966148: 8 560925:1561033:1560808:1562029 176981249 ENSG00000153310 :F AM49B :chr8 :

ENSG00000114062 :UBE3 A:chrl 5 : - ENSG00000132535:DLG4:chrl7:- :25652213:25652284:25650649:2565423 : 130916744: 130916831:130915596: :7095211:7095321:7094677:709626

4 130951853 3

ENSG00000204790 : CB WD6 : chr9 : - ENSG00000132781 :MUTYH:chrl :- ENSG00000214022 :REPIN1 :chr7 :+ :69234829:69234952:69229668:6923556 :45799084:45799236:45798996:458 : 150067802: 150067973: 150066957:

1 00062 150068316

ENSG00000105397:TYK2:chrl9:- ENSG00000139112 : GAB ARAPL 1 :

ENSG00000108591:DRG2:chrl7:+:1800 : 10461727: 10461838: 10461644: 104 chrl2:+: 10366672: 10366786:10366 1583:18001673:17997287:18007114 64717 313:10370661 ENSG00000257621 :PSMA3- ASl:chrl4:- ENSG00000102271 :KLHL4:chrX:+ ENSG00000167851:CD300A:chrl7:

:58740696:58740728:58734111:5875835 :86919763:86919935:86890775:869 +:72469674:72470013:72462882:72 2 21474 470670

ENSG00000100429:HDAC10:chr22

ENSG00000070269:TMEM260:chrl4:+: ENSG00000007545:CRAMPl:chrl

57083900:57084015:57082745:5708531 6:+: 1717335: 1717401: 1716601: 171 :50688855:50688952:50688589:506

1 7962 89199

ENSG00000133519:ZDHHC8Pl:ch

ENSG00000131773 :KHDRBS3 xhr r22:-

ENSG00000103005:USBl:chrl6:+:5804 8:+: 136619197: 136619280: 1365943 :23734913:23735020:23733911:237

8176:58048198:58044016:58051237 16:136659235 41946

ENSG00000121753:ADGRB2:chrl:- ENSG00000175634:RPS6KB2:chrl ENSG00000169398:PTK2:chr8:-

:32205710:32205779:32205635:3220594 1:+:67199823:67199963:67197066: : 141772466: 141772487: 141771361:

7 67200070 141774332

ENSG00000070371 : CLTCL 1 : chr22 :

ENSG00000171385:KCND3:chrl:-

ENSG00000185630:PBX1 :chrl :+: 16478 : 112321057: 112321114: 112319895: : 19178815: 19178947: 19171124: 191 9308:164789421:164781386:164790773 112322846 83776 ENSG00000140750:ARHGAP17:chrl6:- ENSG00000105426 :PTPRS :chrl 9:- ENSG00000178922:HYI:chrl:- :24939004:24939053:24931581:2494210 :5216730:5216778:5215606:521843 :43918573:43918675:43917990:439 4 0 19083

ENSG00000119688:ABCD4:chrl4:- ENSG00000133872 : S ARAF : chr8 : - ENSG00000163743:RCHYl:chr4:- :74766852:74766971:74764772:7476957 :29931392:29931544:29927575:299 :76416820:76416847:76415911:764 7 40362 16933

ENSG00000165275:TRMT10B:chr ENSG00000135336:ORC3:chr6:+:8

ENSG00000088538:DOCK3:chr3:+:513 9:+:37762573:37762682:37762114: 8326031:88326145:88321966:88331

70431:51370458:51367654:51370588 37763625 071

ENSG00000188004:Clorf204:chrl: ENSG00000174353 : STAG3L3 :chr7

ENSG00000101294:HM13:chr20:+:3015 : 159810915: 159811025: 159807817: :72469577 :72469685 :72469313 :724

5880:30156083:30149539:30156922 159824546 69993

ENSG00000137700: SLC37A4 xhrl

ENSG00000159322:ADPGK:chrl5:- ENSG00000166734:CASC4:chrl5: 1:-

:73052747:73052868:73045233:7306412 +:44630434:44630515:44615217:44 : 118897215: 118897398: 118896790:

3 671887 118897646

ENSG00000198208 :RPS6KL 1 xhrl 4:- ENSG00000071462:WBSCR22:chr

ENSG00000148655:C10orfll:chrl0:+:7 :75375803:75375864:75375635:753 7:+:73098096:73098330:73098003:

8295555:78295745:78084243:78316966 76245 73100965

ENSG00000135824:RGS8:chrl:- ENSG00000165948:IFI27Ll:chrl4: ENSG00000128563:PRKRIPl:chr7:

: 182617271 : 182617438: 182616052 : 1826 +:94568159:94568405:94567117:94 +: 102038066: 102038145: 102016769

35103 568822 : 102039994

ENSG00000263878 :DLGAP1 - ENSG00000130707:ASSl:chr9:+:13

ENSG00000031823 :RANBP3 xhrl 9: - AS4:chrl8:+:3995607:3995716:399 3325658:133325720:133320382:133 :5957928:5957984:5941718:5978071 5349:4013618 327610 ENSG00000072803 :FBXW11 :chr5 : ENSG00000031823 :RANBP3 :chrl9

ENSG00000137806:NDUFAFl:chrl5:-

:41686302:41686556:41680720:4168705 : 171423893: 171424055: 171341409: :5957928:5957984:5921332:597807

6 171433461 1

ENSG00000151914:DST:chr6:- ENSG00000144283:PKP4:chr2:+:15

ENSG00000166444 : ST5 :chrl 1 : - :56327843:56327954:56325052:563 9533250:159533379:159530512:159 :8751496:8752756:8747756:8772167 28362 535092 ENSG00000214765 : SEPT7P2 :chr7 :- ENSGOOOOO 138606 : SHF : chrl 5 : - ENSG00000049540:ELN:chr7:+:73 :45765782:45765835:45764079:4576777 :45464346:45464516:45464200:454 480273:73480327:73480062:734829 6 67416 86

ENSG00000186111:PIP5KlC:chrl9

ENSG00000235703 :LINC00894 :chr

ENSG00000168958:MFF:chr2:+:228211 X:+: 149116295: 149116393: 149115 :3633434:3633518:3633167:363888

941:228212100:228207535:228217229 565:149116523 1

ENSG00000076864:RAPlGAP:chrl:- ENSG00000163531:NFASC:chrl:+:

:21991703:21991810:21976289:2199574 ENSG00000132199:ENOSFl:chrl8 204960419:204960434:204957934:2

6 :-:691203:691276:691106:693881 04978684

ENSG00000109919 :MTCH2 :chrl 1 :

ENSG00000138036:DYNC2LIl:chr

ENSG00000126522:ASL:chr7:+:655467 2:+:44023028:44023097:44021782: :47657096:47657123:47652639:476

89:65546984:65541080:65547354 44027979 60250

ENSG00000283580 :RP5- ENSG00000100239:PPP6R2:chr22:

ENSG00000164850:GPERl:chr7:+:1127 994D16.12:chrl:+:43239216:43239 +:50875416:50875497:50874881:50

833:1127957:1126880:1131042 320:43233295:43240407 875934

ENSG00000010361:FUZ:chrl9:- ENSG00000140995:DEF8:chrl6:+: ENSG00000175182:FAM131A:chr3

:50312634:50312832:50312515:5031461 90015824:90016046:90015222:9002 :+:184056174:184056317:18405515

9 0650 9:184059853

ENSG00000119185 :ITGBlBPl:chr

ENSG00000104497:SNX16:chr8:- ENSG00000168405:CMAHP:chr6:- 2:-

:82727559:82727629:82715463:8273602 :25113819:25114010:25110331:251 :9560118:9560229:9558861:956350

6 15218 1

ENSG00000160767:FAM189B:chrl

ENSG00000154556:SORBS2:chr4:- ENSGOOOOO 161547 : SRSF2 : chrl 7 : - : 186598150: 186598792: 186583396: 1865 : 155224190: 155224247: 155223523: :74731853 :74731957:74731240:747 99576 155224443 32235

ENSG00000181409:AATK:chrl7:- ENSG00000110011 :DNAJC4:chrl 1 ENSG00000204231 :RXRB :chr6:-

:79108167:79108301:79105005:7913973 :+:64000175:64000337:63999436:6 :33163139:33163243:33162827:331

7 4001365 63346

ENSG00000155366:RHOC:chrl:- ENSG00000163040:CCDC74A:chr ENSG00000047621:C12orf4:chrl2:-

: 113247721 : 113247745: 113246428: 1132 2:+: 132290282: 132290354: 1322893 :4626226:4626355:4614546:462722

49699 75:132290436 3

ENSG00000231312:AC007246.3:chr2:+: ENSG00000078403:MLLT10:chrl0 ENSG00000121716 :PILRB : chr7 : +: 9

39873401:39873530:39745851:3989222 :+:21823573:21823733:21813704:2 9951517:99951635:99950746:99952

6 1827761 765

ENSG00000161265:U2AFlL4:chrl

9:- ENSG00000064787 :BCAS 1 :chr20: -

ENSG00000100599:RIN3:chrl4:+:9314 :36236025:36236088:36235322:362 :52609050:52609185:52602038:526

2819:93142951:93125814:93151331 36248 11550

ENSG00000283155 :AC011380.9:ch

ENSG00000070961:ATP2Bl:chrl2:- ENSG00000204469 :PRRC2 A:chr6 : r5:-

:89992433:89992520:89985072:8999289 +:31590503:31590678:31588635:31 : 139942247: 139942308: 139942084:

3 592037 139943178

ENSG00000161681:SHANKl:chrl9:- ENSG00000144290:SLC4A10:chr2: ENSG00000174744:BRMS1 :chrl 1 :- :51190273:51190297:51190069:5119083 +:162834231: 162834270: 16283338 :66105713:66105753:66105360:661 8 6:162839688 08244

ENSG00000092096 : SLC22A17:chr

ENSG00000115414:FNl:chr2:- 14:- ENSGOOOOO 196876: SCN8A:chrl2 : :216236831:216237023:216236738:2162 :23816722:23816940:23816145:238 +:52174432:52174555:52168146:52 38044 17369 180325

ENSG00000121957:GPSM2:chrl:+: ENSG00000129197:RPAIN:chrl7:+

ENSG00000151657:KIN:chrl0:- 109428128:109428200:109419850:1 :5331390:5331531:5329402:533586 :7816793:7816854:7811308:7820800 09439485 1

ENSG00000165322:ARHGAP12:ch

ENSG00000006283 : CACNA1 G:chrl7 :+ rlO:- ENSGOOOOO 107771 :CCSER2 :chrlO : :48680180:48680249:48678535:4868037 :32142993:32143134:32141525:321 +:86259630:86259715:86237420:86 5 50322 273204 ENSG00000136828:RALGPSl:chr9:+:l ENSG00000167978:SRRM2:chrl6: ENSG00000196218:RYRl:chrl9:+:

29812321:129812411:129740024:12981 +:2806334:2806607:2802847:28074 39014554:39014569:39013949:3901

5125 72 5971

ENSG00000173915 :USMG5 :chrlO :

ENSG00000064703 :DDX20 :chrl :+: 1123 ENSG00000165359:INTS6L:chrX:+ 03608: 112303747: 112303470: 11230384 : 134681061: 134681190: 134680810: : 105155502: 105155789: 105152223: 7 134683566 105156165

ENSG00000004660:CAMKKl:chrl

ENSG00000006607 :FARP2 :chr2 :+:2423 ENSG00000105865:DUS4L:chr7:+: 7:- 96161:242396337:242375953:24240193 107211589:107211711:107207631:1 :3784920:3785858:3783728:378633 7 07215632 5

ENSG00000162961 :DPY30 : chr2 : - ENSG00000136754:ABIl:chrl0:- ENSG00000144406 :UNC80 :chr2 :+: :32117060:32117203:32108531:3214299 :27047990:27048164:27044670:270 210783255:210783387:210782682:2 4 54146 10786223

ENSG00000121753:ADGRB2:chrl:

ENSG00000099290:WASHC2A:chrl0:+ ENSGOOOOO 136870 :ZNF189 :chr9 :+ :51869860:51870030:51866225:5187365 :32209793:32209958:32207818:322 : 104161676: 104161812: 104161471: 4 10248 104162207

ENSG00000135439:AGAP2:chrl2:- ENSG00000156709:AIFMl:chrX:-

ENSG00000153113 :CAST:chr5 :+: 96062 :58122100:58122160:58121868:581 : 129289130: 129289261: 129283543: 497:96062563:96058402:96063192 23421 129299524

ENSGOOOOO 134152 :KATNBLl:chr

ENSG00000176720:BOK:chr2:+:24 15:-

ENSG00000126522:ASL:chr7:+:655517 2501762:242501891:242498408:242 :34470021:34470200:34455891:345

30:65551808:65551649:65552320 509539 02151

ENSG00000139631:CSAD:chrl2:- ENSG00000140367:UBE2Q2:chrl5 ENSG00000120896:SORBS3:chr8:

:53565661:53565772:53564286:5356712 :+:76152218:76152323:76146828:7 +:22418847:22418886:22415705:22

8 6161291 421499

ENSG00000148541:FAM13C:chrl0

ENSG00000166946:CCNDBPl:chrl5:+: ENSG00000130066:SATl:chrX:+:2

43486278:43486335:43485001:4348661 3802410:23802520:23801826:23803 :61022193:61022405:61014203:610

2 444 28312

ENSG00000175764:TTLLll:chr9:- ENSG00000062598 :ELM02 :chr20 :-

ENSG00000099622:CIRBP:chrl9:+:127 : 124794001: 124794135: 124737258: :45022167:45022240:45021782:450

0865:1271035:1269409:1271327 124801550 22687

ENSG00000164961:WASHC5:chr8:

ENSG00000029363 :BCLAF1 :chr6:-

ENSG00000156990:RPUSD3:chr3 : - : 126095954: 126096264: 126095500: : 136588166: 136588313: 136582615: :9880668:9880855:9879891:9881867 126103856 136589299

ENSG00000106948:AKNA:chr9:- ENSG00000108312:UBTF:chrl7:-

ENSG00000141485:SLC13A5:chrl7:- : 117119142: 117119249: 117118416: :42289711:42289822:42289374:422

:6594097:6594259:6590985:6596362 117120200 90186

ENSG00000166783:KIAA0430:chr

16:- ENSG00000167535:CACNB3:chrl2

ENSG00000124275:MTRR:chr5:+:7873 : 15719228: 15719657: 15719030: 157 :+:49218731:49218751:49218516:4 485:7873639:7871036:7875370 24188 9218945 ENSG00000240771:ARHGEF25:chrl2: ENSGOOOOO 197122 : SRC : chr20 :+ : 3 ENSG00000141568:FOXK2:chrl7: +:58010566:58011071:58010278:580130 6014862:36014880:36014577:36022 +:80540616:80540810:80529746:80 93 297 543779

ENSG00000277363 : SRCINl :chrl7:

ENSG00000117598:PLPPR5:chrl:- ENSG00000157445:CACNA2D3:ch

:99380356:99380476:99358660:9938743 r3:+:55021709:55021780:55018697: :36724458:36724479:36720549:367

7 55038789 34742

ENSG00000110888:CAPRIN2:chrl2:- ENSG00000048162:NOP16:chr5:- ENSG00000148090:AUH:chr9:-

:30872012:30873849:30869610:3087619 : 175813840: 175813910: 175812328: :93979558:93979609:93976707:939

2 175815433 83086

ENSG00000067221 : STOML 1 :chrl 5

ENSG00000068903 : SIRT2 :chrl9 : -

ENSG00000197343:ZNF655:chr7:+:991 :39389018:39389065:39380784:393 :74276999:74277209:74276471:742

60810:99160889:99158318:99161485 90145 77658

ENSG00000173480:ZNF417:chrl9:

ENSG00000130749:ZC3H4:chrl9:-

ENSGOOOOOH5459:ELMOD3:chr2:+:85 :58423427:58423557:58421482:584 :47572348:47572600:47571126:475

582198:85582293:85581952:85582677 27746 75034

ENSG00000005379:TSPOAPl:chrl7:- ENSG00000160801 :PTHlR:chr3 :+: ENSG00000169756:LIMSl:chr2:+:

:56382747:56382819:56379808:5638290 46942514:46942575:46940347:4694 109297424:109297568: 109297226: 1

0 2903 09300340 ENSG00000089022 :MAPKAPK5 :chrl2 : ENSG00000143106 :PSMA5 xhrl :- ENSGOOOOO 163875 :MEAF6:chrl :- +: 112308074: 112308164: 112306665: 112 : 109964481 : 109964548 : 109957985 : :37962147:37962205:37961519:379 308888 109968923 67404

ENSGOOOOO 132600 :PRMT7 : chrl 6 : ENSG00000250305:KIAA1456:chr

ENSG00000105429:MEGF8:chrl9:+:42 +:68382244:68382334:68380183:68 8:+: 12848342: 12848540: 12809867: 875501 :42875634:42874983 :42879658 386150 12863710

ENSG00000148341:SH3GLB2:chr9

ENSG00000149100:EIF3M:chrll:+

ENSG00000141258:SGSM2:chrl7:+:22 :32610557:32610681:32605475:326 : 131772948: 131772972: 131772488:

70564:2270699:2268635:2274555 11092 131776689

ENSG00000093167 :LRRFIP2 :chr3 : ENSG00000186532:SMYD4:chrl7:

ENSG00000125354:SEPT6:chrX:-

: 118759297: 118759342: 118750705 : 1187 :37107714:37107816:37107433:371 : 1715264: 1715409: 1708009: 173115

63280 14280 4

ENSG00000113597 :TRAPPC 13 : chr5 : +: ENSG00000110921 :MVK:chrl2:+: ENSGOOOOO 155970 :MICU3 :chr8 :+: 64951462:64951480:64948372:6495419 110019199:110019355:110013950:1 16973951:16974109:16971710:1697

4 10023826 6215

ENSG00000162910:MRPL55:chrl> ENSG00000122490:PQLCl:chrl8:-

:228296137:228296175:228296019:2282 ENSG00000188157:AGRN:chrl:+: :77693968:77694022:77679400:777

96655 986411:986423:986217:986632 03328 ENSG00000105662:CRTCl:chrl9: ENSG00000141524:TMC6:chrl7:-

ENSG00000083799:CYLD:chrl6:+:508 +: 18885709: 18885796: 18876338: 18 :76120969:76121066:76120862:761

09076:50809085:50788335:50810089 886450 21238

ENSG00000269352:PTOV1-

AS2:chrl9:- ENSG00000110514:MADD:chrll:+ ENSG00000078328:RBFOXl:chrl6

:50361810:50361883:50361684:5036209 :47330530:47330593:47330250:473 :+:7743316:7743369:7726840:7759

9 30831 057

ENSG00000132376:INPP5K:chrl7:

ENSG00000004864 : SLC25 A13 :chr7 :- ENSGOOOOO 119787 : ATL2 : chr2 : - :95864113:95864229:95838289:9590650 : 1416746: 1416855: 1413093: 141716 :38523827:38523842:38523732:385 7 5 25285

ENSG00000220785 :MTMR9LP:chr

ENSG00000172661:WASHC2C:chrl0:+ 1:- ENSG00000214022 :REPIN1 :chr7 :+

:46254762:46254849:46252587:4625883 :32704895:32705026:32697785:327 : 150067848: 150067973 : 150066030:

5 05469 150068316

ENSG00000088367:EPB41Ll:chr2 ENSG00000128596:CCDC136:chr7

ENSG00000119650:IFT43:chrl4:+:7652 0:+:34802278:34802362:34800298: :+: 128450192: 128450420: 12844759

5669:76525716:76488737:76548637 34806797 9:128457811

ENSG00000167770:OTUB 1 xhrl 1 : ENSG00000214548:MEG3:chrl4:+:

ENSG00000084623:EIF3I:chrl:+:32694 +:63755808:63755870:63753986:63 101302378:101302412:101302216:1

099:32694210:32690076:32696527 764001 01302503

ENSG00000006025 :0SBPL7 :chrl7:

ENSG00000105290:APLPl:chrl9:+

ENSG00000124787 :RPP40 : chr6 : - :45891886:45891980:45891200:458 :36368983:36369010:36368727:363 :5000796:5000865:5000138:5002334 92580 69485 ENSG00000138434:S SF A2 : chr2 : +: 1827 ENSG00000133392:MYHll:chrl6:- 83049:182783197:182781732:18278332 ENSG00000023191 :RNH1 xhrl 1 :- : 15878554: 15878575: 15876334: 158 4 :504823:504996:502249:507112 80486

ENSG00000149582 :TMEM25 :chrl 1 :+: 1 ENSG00000166452: AKIP1 xhrl 1 :+ ENSG00000061273:HDAC7:chrl2:- 18402489:118402586:118401949:11840 :8933999:8934080:8933218:893637 :48196006:48196057:48192755:482 4571 2 13549

ENSG00000143850:PLEKHA6:chrl

ENSG00000137817:PARP6:chrl5:- ENSG00000122707:RECK:chr9:+:3 :72543185:72543295:72535040:7254354 6112301:36112473:36110076:36116 :204212241:204212391:204210942: 7 981 204214742

ENSG00000147044:CASK:chrX:- ENSG00000175470:PPP2R2D:chrl

ENSG00000134376:CRBl:chrl:+: 19741 :41419031:41419100:41416353:414 0:+: 133748397: 133748510: 1337480 1295:197411664:197407805:197446793 20811 59:133753534 ENSGOOOOO 100207 :TCF20 : chr22 : - ENSG00000136153:LM07:chrl3:+: ENSG00000137221:TJAPl:chr6:+:4 :42564614:42564742:42557364:4256585 76412275:76412332:76410593:7641 3470325:43470355:43470087:43471 2 4220 138

ENSG00000099957 :P2RX6 :chr22 :+ ENSG00000076685 :NT5C2 :chrlO : -

ENSG00000100083:GGAl:chr22:+:3802 :21380299:21380618:21380187:213 : 104871501: 104871562: 104866463:

0975:38021083:38019640:38025468 80708 104934614

ENSG00000166340:TPPl:chrll:-

ENSG00000135164:DMTFl:chr7:+:868 :6640426:6640498:6639007:664061 ENSG00000109685:NSD2:chr4:+:l

23999:86824144:86823418:86824346 4 944065:1944159:1941505:1952798 ENSG00000095637:SORBSl:chrl0:

ENSG00000107263 :RAPGEF 1 : chr9 : - ENSG00000131626:PPFIA1 xhrl 1 : : 134494437: 134494596: 134477536: 1344 +:70211478:70211541:70208594:70 :97174250:97174412:97170534:971 97182 212046 81717

ENSG00000165948:IFI27Ll:chrl4: ENSG00000111237: VPS29:chrl2:-

ENSG00000147905 :ZCCHC7 :chr9 :+: 37 +:94568159:94568321:94563311:94 : 110936624: 110936664: 110934008: 304184:37304310:37126939:37305540 568822 110937339

ENSG00000242574:HLA-

ENSG00000105402:NAPA:chrl9:- ENSG00000044115: CTNNA1 : chr5 : DMB:chr6:-

:48006649:48006759:48004006:4801809 +: 138216730: 138216826: 13821128 :32903118:32903154:32902764:329

9 6:138221900 03312

ENSG00000175471:MCTPl:chr5:- ENSG00000163964:PIGX:chr3:+:19

ENSG00000140939:NOL3:chrl6:+:6720 :94134717:94134837:94114868:942 6453525:196453642:196449427:196

7910:67207949:67204477:67208064 04037 454793

ENSG00000160293:VAV2:chr9:- ENSG00000075413 :MARK3 :chrl4 :

ENSG00000143774:GUKl:chrl:+:22833 : 136675312: 136675327: 136674260: +: 103966492: 103966537: 103964865 6071:228336157:228335400:228336365 136677235 :103969218 ENSG00000117262 :GPR89A:chrl : - ENSG00000143157:POGK:chrl :+: 1 ENSG00000121067:SPOP:chrl7:- : 145822813: 145822859: 145818826: 1458 66815848:166815975:166810325:16 :47745388:47745440:47700238:477 26887 6818174 53256

ENSG00000172046:USP19:chr3:- ENSG00000139974:SLC38A6:chrl ENSG00000260916:CCPGl:chrl5:-

:49154899:49155003:49154376:4915508 4:+:61453769:61453875:61451521: :55666352:55666448:55664242:556

9 61482621 69146

ENSG00000138036:DYNC2LIl:chr ENSG00000153310:FAM49B:chr8:-

ENSG00000178188:SH2Bl:chrl6:+:288 2:+:44023025:44023097:44021782: : 130916744: 130916831:130915596:

84490:28884590:28884079:28884767 44027979 130983188

ENSG00000079819:EPB41L2:chr6:

ENSG00000124831 :LRRFIP1 :chr2:+:23 ENSG00000136717:BINl:chr2:- 8647874:238647952:238536383:238657 : 131191467: 131191521: 131188721: : 127811480: 127811588: 127808819: 006 131206235 127815048

ENSG00000078053:AMPH:chr7:- ENSG00000124357:NAGK:chr2:+: ENSG00000136717:BINl:chr2:- : 38469441 :38469465 :38469177 : 3847178 71302691:71302772:71300724:7130 : 127809830: 127809938: 127808819: 8 3733 127810997

ENSG00000212694:LINC01089:chrl2:- ENSG00000091972 : CD200 :chr3 :+: ENSGOOOOO 177311 :ZBTB38:chr3 :+ : 122240536: 122240690: 122239714: 1222 112054789: 112054864: 112052071 : 1 : 141157084: 141157207: 141122873 : 40784 12059748 141161230

ENSG00000172531 :PPPlCA:chrl 1 :

ENSG00000139116:KIF21A:chrl2:- ENSG00000159082:SYNJl:chr21:-

:39740267:39740306:39735926:3974557 :67168538:67168703:67168390:671 :34007170:34007191:34004111:340

8 69198 11217

ENSG00000260643 :RP11 -

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000204790 :CBWD6 :chr9 :- 303E16.8:chrl6:-

1702877:131702994:131698924:131703 :69261238:69261336:69259308:692 :81091509:81091669:81087699:811

723 69395 18067

ENSG00000079819:EPB41L2:chr6:

ENSG00000180964 :TCEAL8 xhrX:- ENSG00000136699:SMPD4:chr2:- : 102509532: 102509605: 102508945: 1025 : 131184777: 131184858: 131161738: : 130918758: 130918845: 130914248: 10005 131206235 130921946

ENSG00000089820:ARHGAP4:chrX:- ENSG00000183010:PYCRl:chrl7:- : 153175624: 153175858: 153175539: 1531 ENSG00000118900:UBNl:chrl6:+: :79892528:79892621:79891252:798 75959 4918833:4918904:4911103:4920212 92801

ENSGOOOOO 158796 :DEDD xhrl :- ENSG00000159753:CARMIL2:chrl ENSG00000266714:MY015B:chrl

: 161100604: 161100637: 161094316: 1611 6:+:67690736:67690784:67690548: 7:+:73588544:73588622:73588382:

02340 67691141 73588759

ENSGOOOOO 125814 :NAPB :chr20 : - ENSG00000183386:FHL3:chrl:- :23377708:23377825:23375636:2338362 :38464928:38465104:38464820:384 ENSG00000103126:AXINl:chrl6:- 9 71110 :341189:341297:339607:343487

ENSG00000072210:ALDH3A2:chrl7:+: ENSG00000102317:RBM3 :chrX:+: ENSG00000005700:IBTK:chr6:-

19576463:19576588:19575269:1957887 48434202:48434471:48434055:4843 :82949882:82950560:82943972:829

4 4701 57278

ENSG00000111144:LTA4H:chrl2:- ENSGOOOOO 101190 : TCFL5 : chr20 : - ENSG00000185920:PTCHl:chr9:- :96397615:96397698:96396842:9640009 :61485367:61485509:61473449:614 :98239828:98239984:98239139:982

1 91476 40336

ENSG00000175662:TOMlL2:chrl7

ENSG00000050405:LIMAl:chrl2:- ENSG00000025293:PHF20:chr20:+:

:50586234:50586347:50575820:5058961 : 17786018: 17786177: 17783057: 177 34435271:34435356:34430666:3445

2 96974 0934 ENSG00000182796 :TMEM198B :chrl2 : ENSG00000173406:DAB 1 :chrl :- ENSG00000077522 : ACTN2 :chrl :+:

+:56226742:56226822:56224867:562272 :57476352:57476463:57463801:574 236897732:236897818:236894614:2

30 76817 36902601

ENSGOOOOO 125846 :ZNF 133: chr20 : ENSG00000251503:APITD1-

ENSG00000105778:AVL9:chr7:+:32619 +: 18286941: 18287037: 18269248: 18 CORT:chrl:+: 10502321: 10502498:1

830:32619884:32613030:32620413 295712 0500470:10511433

ENSG00000150433:TMEM218:chr

ENSG00000119242:CCDC92:chrl2:- 11:- ENSG00000203875 : SNHG5 :chr6 :- : 124429215 : 124429287: 124428911 : 1244 : 124972027 : 124972213 : 124971199: :86387508:86387593:86387210:863 30250 124972629 87671

ENSG00000175662:TOMlL2:chrl7:- ENSGOOOOO 101004 :NINL :chr20 : - : 17761082: 17761169: 17754266: 1776478 ENSG00000130731:METTL26:chrl :25477298:25477439:25472161:254 9 6:-:684888:684956:684797:686093 84587

ENSG00000228315:GUSBPll:chr2

ENSG00000100376:FAM118A:chr22:+: 2:- ENSGOOOOO 154144 :TBRG1 :chrl 1 :

45726483:45726612:45719308:4572830 :24025911:24026054:24002187:240 +: 124496368: 124496505: 124495799

5 32422 : 124496799

ENSG00000116604 :MEF2D:chrl :- ENSG00000165219:GAPVDl:chr9: ENSG00000115310:RTN4:chr2:- : 156446285: 156446306: 156445029: 1564 +: 128104497: 128104578: 12810354 :55252221:55254621:55214834:552 46803 3:128109097 55299

ENSG00000118997 :DNAH7 :chr2 :- ENSG00000125462:Clorf61:chrl:- ENSG00000153207:AHCTFl:chrl:-

: 196661299: 196661461 : 196659262 : 1966 : 156386560: 156386656: 156384545: :247005995:247006078:247004300:

64019 156391346 247012916

ENSG00000112983 :BRD8:chr5 :- ENSG00000214140 :PRCD :chrl7 :+:

ENSG00000118894 :EEF2KMT:chrl6:- : 137504158: 137504377: 137503767: 74541611:74541718:74540452:7454 :5140084:5140350:5139257:5140432 137504910 9190 ENSG00000164896 :FASTK:chr7:- ENSG00000108175:ZMIZl:chrl0:+ ENSG00000183495:EP400:chrl2:+: : 150773999: 150774323: 150773919: 1507 :80921809:80921890:80899534:809 132505623 :132505866: 132504763: 1 74396 61340 32508321

ENSG00000110172:CHORDCl:chr

ENSG00000066557:LRRC40:chrl:- 11

ENSG00000103148:NPRL3:chrl6:- :70652947:70653021:70650597:706 :89948341:89948398:89943762:899 : 174935: 175072: 169254: 180520 71072 51302

ENSG00000100445:SDR39Ul:chrl

4:- ENSG00000180902:D2HGDH:chr2:

ENSG00000137210:TMEM14B:chr6:+:l :24911314:24911466:24911001:249 +:242689565:242689709:242684292 0749854: 10749931 : 10748114: 10755374 11551 :242695263

ENSG00000254995:STX16- ENSG00000179094:PERl:chrl7:-

ENSG00000163629:PTPN13:chr4:+:876 NPEPLl:chr20:+:57266089:572662 :8049275:8049455:8048311:804968

22393:87622954:87614827:87637682 83:57248767:57266460 9 ENSG00000243156 :MICAL3 :chr22 ENSG00000073584: SMARCE 1 :chr

ENSG00000214078:CPNEl:chr20:- 17:-

:34220084:34220170:34219947:3422023 :18310409:18310547:18305826:183 :38798706:38798811:38793824:388

2 14619 01827

ENSG00000129646:QRICH2:chrl7:

ENSGOOOOO 164576 : S AP30L :chr5 :+

ENSGOOOOO 132639: SNAP25 :chr20 :+: 10 :74287095:74290102:74286158:743 : 153832015: 153832055: 153830773: 265371:10265420:10258374:10277572 00495 153832961

ENSG00000181163 :NPM1 :chr5 :+: 1 ENSGOOOOO 196498 :NC0R2 :chrl2 :-

ENSG00000214021:TTLL3:chr3:+:9859 70827156:170827214:170815010:17 : 124825147: 124825297: 124824989:

328:9860604:9855029:9862229 0832305 124826368

ENSG00000166676:TVP23A:chrl6:

ENSGOOOOO 141504 : SAT2 : chrl 7 : -

ENSG00000065802:ASBl:chr2:+:23934 :7530024:7530111:7529932:753046 : 10868808: 10868953: 10867985: 109

4351:239344654:239342336:239352982 0 12341

ENSG00000156170 :NDUFAF6:chr ENSG00000204351:SKIV2L:chr6:+

ENSG00000004660:CAMKK1 :chrl7:- 8:+:96046235:96046350:96044326: :31928972:31929163:31928871:319 :3785821:3785858:3783728:3786335 96047681 29323 ENSGOOOOO 146067 :FAM193B :chr5 : - ENSG00000136153:LM07:chrl3:+: ENSG00000168297:PXK:chr3:+:58 : 176959443 : 176959642: 176952206: 1769 76429395:76429504:76427524:7643 398627:58398690:58395886:584104 80168 0641 78

ENSGOOOOO 198837 :DENND4B :chrl :- ENSG00000133083:DCLKl:chrl3:- ENSG00000137343:ATATl:chr6:+: : 153915031:153915101: 153914589: 1539 :36362348:36362422:36348836:363 30608311:30608380:30608199:3060 15353 67502 9952

ENSG00000146021:KLHL3:chr5:- ENSG00000114867:EIF4Gl:chr3:+: ENSG00000070476:ZXDC:chr3:- : 136969725: 136969854: 136964126: 1369 184033859:184034006:184032462:1 : 126160607: 126160789: 126158570: 93819 84035108 126180377 ENSGOOOOOH7859:OSBPL9:chrl: ENSG00000151292:CSNKlG3:chr5

ENSG00000184014:DENND5A:chrll:- +:52135105:52135184:52117713:52 :+: 122941032: 122941056: 12294052

:9228719:9228755:9228329:9229107 179674 4:122950035

ENSG00000273000:KB-

1572G7.2:chr22:- ENSG00000197343:ZNF655:chr7:+

ENSG00000205937:RNPSl:chrl6:- :24029017:24029182:24026054:240 :99169310:99169415:99158318:991 :2314573:2314761:2314332:2318055 32418 69867 ENSG00000198270 :TMEM116 :chrl2: - ENSG00000157445:CACNA2D3:ch ENSG00000163697:APBB2:chr4:- : 112370389:112370535: 112369631:1123 r3:+:54850879:54850897:54798378: :40827903:40827984:40825776:408 71689 54871185 29148

ENSG00000147687:TATDNl:chr8:

ENSG00000223891:OSER1- ENSG00000135541:AHIl:chr6:-

AS1 :chr20:+:42843527:42843643 :42839 : 135618569: 135618630: 135611663: : 125535177: 125535243: 125520929:

996:42853460 135621637 125551265

ENSG00000079819:EPB41L2:chr6:

ENSG00000156414:TDRD9:chrl4:

ENSG00000036448:MYOM2:chr8:+:20 : 131188598: 131188721: 131186774: +: 104516201: 104516274: 104516017

89063:2089100:2088809:2091324 131206235 : 104518317

ENSG00000231925 : TAPBP : chr6 : - ENSG00000137103:TMEM8B:chr9:

ENSG00000140455:USP3:chrl5:+:6382 :33280993 :33281254:33273164:332 +:35835007:35835215:35829952:35 1212:63821365:63797029:63824845 81470 841130 ENSG00000053108:FSTL4:chr5:- ENSG00000136110:CNMD:chrl3:- ENSG00000128739:SNRPN:chrl5: : 132559881: 132559908: 132556558: 1325 :53298131:53298245:53287004:533 +:25219434:25219603:25213229:25 60841 07353 221451

ENSG00000136717:BINl:chr2:- ENSG00000064042 :LIMCH1 :chr4 : ENSGOOOOO 168802 :CHTF8 :chrl6 : - : 127815048: 127815177: 127808488: 1278 +:41689856:41689934:41687847:41 :69154955:69155073:69154552:691 16586 691543 55338

ENSG00000138382:METTL5:chr2:- ENSG00000145362:ANK2:chr4:+:l ENSG00000078018 :MAP2 :chr2 :+:2 : 170668966: 170669034: 170668368: 1706 14294440: 114294605 : 114294329: 11 10557360:210561074:210545551:21 71986 4302612 0565000

ENSG00000133657:ATP13A3:chr3:- ENSG00000171163 :ZNF692:chrl :- : 194132927: 194133017: 194126845: 1941 ENSG00000007376 :RPUSD 1 :chrl6 :249150486:249150621:249150145: 34487 :-:837555:837744:837477:838255 249150712

ENSG00000117308:GALE:chrl:- ENSG00000233184:RP11-

ENSG00000134369:NAVl:chrl:+:20175 :24122998:24123076:24122755:241 421L21.3:chrl:+: 101549016: 101549

9681:201759705:201758920:201759816 23186 130:101491617:101552407

ENSG00000166682:TMPRSS5:chrl

ENSG00000103494:RPGRIPlL:chrl6:- 1:- ENSG00000156873:PHKG2:chrl6:

:53672221:53672323:53671766:5367494 : 113570316: 113570415: 113569749: +:30767502:30767593:30764878:30

4 113576943 767910

ENSG00000152348:ATG10:chr5:+: ENSG00000038532:CLEC16A:chrl

ENSG00000126653 :NSRP1 :chrl7:+:284 81354313:81354421:81283497:8146 6:+: 11268010: 11268134: 11260409: 45097:28445191:28443881:28483557 0217 11272191

ENSG00000165795:NDRG2:chrl4:

ENSG00000164418 : GRIK2 : chr6 : +: 1025 ENSG00000031081:ARHGAP31:ch 13671 : 102513803 : 102503455: 10251622 :21492144:21492255:21491480:214 r3 :+: 119087218: 119087363: 119084 1 92984 265:119099750

ENSGOOOOO 156042 : CF AP70 :chrl 0 :

ENSG00000110514:MADD:chrll:+

ENSG00000082397:EPB41L3:chrl8:- :47314093 :47314147:47312367:473 :75036997:75037119:75035356:750

:5394675:5394792:5393477:5395065 15433 37936

ENSG00000077044:DGKD:chr2:+: ENSGOOOOO 171055 :FEZ2 : chr2 : -

ENSG00000117335 :CD46:chrl:+:20794 234355357:234355442:234354408:2 :36787927:36788008:36782891:368 1123:207941168:207940540:207943665 34356732 05739 ENSG00000100505:TRIM9:chrl4:- ENSG00000186654:PRR5:chr22:+: ENSG00000158806:NPM2:chr8:+:2 :51452673:51452862:51450139:5146476 45130906:45131042:45122514:4513 1883157:21883283:21883032:21890 7 2651 640

ENSG00000165322:ARHGAP12:ch

ENSG00000136856:SLC2A8:chr9:+:130 rlO:- ENSGOOOOO 137726:FXYD6 :chrl 1 : -

159654:130159817:130159565:1301621 :32128232:32128247:32120728:321 : 117710951: 117711083: 117710545:

85 28564 117711862

ENSG00000161647:MPP3:chrl7:- ENSG00000049618:ARIDlB:chr6: ENSGOOOOO 196199 :MPH0SPH8 :ch

:41894044:41894065:41893447:4189541 +: 157454161: 157454341: 15743169 rl3:+:20244979:20245104:2024450

3 5:157469757 3:20245345

ENSG00000122490:PQLCl:chrl8:-

ENSG00000197283:SYNGAPl:chr6:+:3 :77690227:77690311:77679400:777 ENSG00000067191: CACNB 1 :chrl7

3416565:33416645:33415710:33419536 03328 :37341383:37341403:37340636:373

42748

ENSG00000108509:CAMTA2:chrl

ENSG00000139116:KIF21A:chrl2:- 7:- ENSG00000070814:TCOFl:chr5:+:

:39709733:39709772:39705355:3971187 :4885383 :4885522:4884654:488605 149758791 : 149758971 : 149758605: 1

4 1 49759094

ENSG00000148341:SH3GLB2:chr9

ENSG00000130779:CLIPl:chrl2:- ENSG00000128596:CCDC136:chr7 : 122831921 : 122832026: 122826244: 1228 :+: 128457811 :128457918:12845298 : 131775286: 131775298: 131774577: 37272 3:128461852 131776689

ENSG00000197603 : C5orf42 :chr5 : - ENSG00000079691 : C ARMIL 1 : chr6

ENSG00000035115:SH3YLl:chr2:- :37157414:37157564:37154095:371 :+:25612964:25613114:25610409:2

:242797:242871:234272:247537 57771 5619674

ENSG00000151640:DPYSL4:chrl0:+:13 ENSG00000112305 :SMAPl:chr6:+: ENSG00000125462:Clorf61:chrl:-

4016149:134016329:134015620:134017 71501391:71501472:71483128:7150 : 156376871: 156376989: 156374393:

265 8359 156389962

ENSG00000172663:TMEM134:chr

ENSG00000183077:AFMID:chrl7: 11

ENSG00000124357:NAGK:chr2:+:7129 +:76201683:76201819:76198832:76 :67232526:67232571:67232327:672

7631:71297716:71295842:71297870 202026 34782

ENSG00000092841:MYL6:chrl2:+:

ENSG00000204498:NFKBIL1 :chr6:+:31 56553370:56553406:56552495:5655 ENSG00000125826:RBCKl:chr20: 524473:31524560:31516216:31525404 3758 +:390527:390669:389423:398169

ENSG00000271853:RP1- ENSGOOOOO 134313 :KIDINS220:chr

ENSG00000126214:KLCl:chrl4:+:1041 178F15.5:chrl:- 2:-

51322:104151373:104145855:10415197 : 153600596: 153600713: 153600074: :8957747:8957846:8953465:897760

4 153604509 9

ENSG00000111647:UHRFlBPlL:chrl2: ENSG00000103145:HCFClRl:chrl

ENSG00000163913:IFT122:chr3:+: 6:-

: 100522357: 100522503: 100502326: 1005 129210983:129211037:129207240:1 :3073474:3073531:3073362:307418 36369 29214288 1

ENSG00000147799 : ARHGAP39 :ch r8:- ENSG00000107404:DVLl:chrl:-

ENSG00000132639: SNAP25 :chr20 :+: 10 : 145770632: 145771194: 145759586: : 1272397: 1272435: 1271895: 127335 273529:10273647:10258374:10277572 145780943 6

ENSG00000275052:PPP4R3B:chr2:

ENSG00000164576:SAP30L:chr5:+:153 ENSG00000163539:CLASP2:chr3:-

832015:153832059:153830773:1538329 :33615964:33615988:33614846:336 :55805382:55805478:55804492:558

61 17660 06814

ENSG00000111907:TPD52Ll:chr6: ENSG00000114416:FXR1 :chr3 :+: 1

ENSG00000169727:GPSl:chrl7:+:8001 +: 125578243 : 125578304: 12556952 80693100:180693192:180688146:18 0253:80010335:80009840:80011149 9:125583979 0693909 ENSG00000132781 :MUTYH:chrl : - ENSG00000154582:ELOC:chr8:- ENSG00000164758:MED30:chr8:+: :45798245:45798359:45797982:4579843 :74871999:74872053:74868289:748 118540889:118541048:118533292:1 4 84311 18552121

ENSG00000168894:RNF181:chr2:+ ENSG00000214655:ZSWIM8:chrl0

ENSG00000131626:PPFIAl:chrll:+:70 :85823979:85824054:85823772:858 :+:75551081:75551257:75550934:7

196028:70196145:70194526:70197099 24567 5551616

ENSG00000105426 :PTPRS :chrl 9 ENSGOOOOO 140092 :FBLN5 :chrl4 : -

ENSG00000102125:TAZ:chrX:+: 153648 :5229326:5229353:5225855:522950 :92406193:92406294:92403545:924 043:153648085:153642527:153648370 1 06908 ENSG00000204842 : ATXN2 :chrl2: - ENSG00000145819:ARHGAP26:ch ENSG00000106948:AKNA:chr9:- : 111953957:111954167: 111951343:1119 r5 :+: 142587008: 142587038: 142526 : 117143339:117143726:117139812: 56052 946:142593561 117150139

ENSG00000119421 :NDUFA8 :chr9 :- ENSGOOOOO 142192 : APP : chr21 : - ENSGOOOOO 109065 :NAT9 :chrl7: - : 124914523: 124914687: 124910556: 1249 :27372329:27372497:27354790:273 :72771760 :72771991 :72769824 :727 21905 94155 72405

ENSG00000044115:CTNNAl:chr5:+:13 ENSG00000163964:PIGX:chr3:+:l ENSG00000198089:SFIl:chr22:+:3

8216730:138216826:138211427:138221 96448047 : 196448227 : 196443792 : 19 1927043:31927115:31904362:31942

900 6449285 846

ENSG00000111711 :G0LT1B :chrl2 ENSGOOOOO 160191 :PDE9 A :chr21 : +

ENSG00000134780:DAGLA:chrll:+:61 :+:21668171:21668204:21665310:2 :44108026:44108104:44073993:441 488150:61488339:61487722:61490330 1668602 19077 ENSG00000196923 :PDLIM7:chr5 : - ENSG00000058453:CROCC:chrl:+ ENSG00000178209:PLEC:chr8:- : 176918807: 176918926: 176918421: 1769 : 17295610: 17295835: 17294913: 172 : 145012568: 145012583: 145012408: 19405 96747 145012798 ENSG00000274602:PI4KAP1 :chr22

ENSG00000276550:HERC2P2:chrl5:- ENSG00000164548:TRA2A:chr7:-

:23356105:23356220:23339028:2337742 :20386516:20387279:20385815:203 :23561739:23562051:23561459:235

3 88299 71407

ENSG00000100505:TRIM9:chrl4:- ENSG00000205763:RP9P:chr7:- ENSG00000058866:DGKG:chr3:- :51452673:51452862:51450139:5147579 :32973425:32973508:32961042:329 : 185978227: 185978302: 185975728: 7 82481 185985473

ENSG00000104723 :TUSC3 :chr8:+: ENSG00000171570:RAB4B-

ENSG00000114956:DGUOK:chr2:+:741 15615299:15615364:15605974:1561 EGLN2:chrl9:+:41289825:4128998 73845:74174033:74154179:74184251 5538 0:41284296:41292569 ENSG00000271147: ARMCX5 - ENSG00000152784:PRDM8:chr4:+ ENSGOOOOOO 11347: SYT7 :chrl 1 : - GPRASP2:chrX:+: 101856807: 10185690 :81118116:81118370:81117755:811 :61313502:61313727:61300596:613 5:101854775:101860409 18778 18855

ENSG00000143409:MINDYl:chrl:

ENSG00000185630:PBXl:chrl:+:l

ENSG00000136811:ODF2:chr9:+:13123 64789308:164789421:164781386:16 : 150974640: 150975444: 150974258: 1461:131231632:131223346:131233586 4815820 150978787 ENSG00000113758:DBN1 :chr5 :- ENSG00000066117: SMARCD 1 : chr ENSG00000243989:ACYl:chr3:+:5 : 176886603 : 176886741 : 176886269: 1768 12:+:50482303:50482420:50480661 2019222:52019287:52018174:52019 87432 :50483666 867

ENSG00000245526:LINC00461:chr

ENSG00000127952 : STYXL 1 :chr7 :- ENSG00000155265:GOLGA7B:chr 5:- :75659738:75659842:75634722:7567712 10:+:99619214:99619340:99610072 :87968782:87968908:87966903:879 9 :99623924 80474

ENSG00000006837:CDKL3:chr5:- ENSG00000168538:TRAPPC11 :chr ENSG00000139116:KIF21A:chrl2:- : 133637830: 133637901: 133634401: 1336 4:+: 184603884: 184603978: 1846006 :39709030:39709042:39705355:397 38280 39:184605127 09733

ENSG00000185008:ROB02:chr3:+: ENSG00000087495:PHACTR3:chr2

ENSG00000099917:MED15:chr22:+:20 77652085 :77652211 :77651642 :7765 0:+:58342240:58342450:58330419:

909222:20909435:20891491:20918736 6948 58348333

ENSG00000135127:BICDLl:chrl2:+:12 ENSG00000091129 :NRCAM:chr7:- ENSG00000160789:LMNA:chrl:+:

0529050:120529205:120528823:120530 : 107815766: 107815802: 107800937: 156108278:156108548:156107534:1

803 107816874 56109560

ENSG00000163531 :NFASC:chrl :+:204 ENSG00000117868:ESYT2:chr7:- ENSG00000110274:CEP164:chrll: 889759:204889868:204797910:2049133 : 158545471: 158545534: 158542414: +: 117234144:117234222:117233254 53 158552176 :117241795

ENSG00000150401:DCUNlD2:chr

ENSG00000136450:SRSFl:chrl7:- 13:- ENSG00000141452:C18orf8:chrl8:

:56082758:56082961:56082402:5608316 : 114138154: 114138371: 114135058: +:21086933:21087018:21084411:21

1 114144981 095819

ENSG00000204256:BRD2:chr6:+:3 ENSG00000167645:YIFlB:chrl9:-

ENSG00000143742:SRP9:chrl:+:22597 2946866:32946971:32946165:32947 :38797553:38797630:38796147:387

6735:225976843:225971070:225976941 604 98067

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000068903 : SIRT2 :chrl9 : - ENSG00000024048 :UBR2 :chr6 :+:4

1700035:131700057:131698924:131703 :39389433:39389558:39389065:393 2633146:42633250:42631157:42633

723 90145 904

ENSG00000082397:EPB41L3:chrl

8:- ENSG00000169919:GUSB:chr7:-

ENSG00000178950:GAK:chr4:- :5398019:5398142:5397425:540096 :65444713:65444898:65441189:654 :853149:853281:844872:853393 7 45210 ENSG00000138279 :ANXA7 :chrlO :- ENSG00000100242 : SUN2 :chr22 : - ENSGOOOOO 124831 :LRRFIP1 :chr2: :75160560:75160615:75157032:7517376 :39150646:39150711:39148670:391 +:238667371:238667464:238666191 9 51767 :238668706

ENSG00000163346:PBXIPl:chrl:- ENSG00000131697:NPHP4:chrl:- ENSG00000164548:TRA2A:chr7:- : 154926146: 154926233: 154920842: 1549 :5925161:5925333:5924577:592643 :23570799:23570889:23562051:235 28544 2 71407

ENSG00000170011 :MYRIP:chr3 :+: ENSG00000138162:TACC2:chrl0:

ENSG00000160299:PCNT:chr21:+:4786 40275386:40275544:40251584:4028 +: 123974917: 123974966: 123971223 4606:47864734:47862486:47865196 5936 :123976141 ENSG00000145428:RNF175:chr4:- ENSG00000112787 :FBRSLl:chrl2: ENSGOOOOO 120910 :PPP3 CC : chr8 : + : 154669796: 154669938: 154649513: 1546 +: 133104538: 133104574: 13308493 :22396981:22397011 :22390531 :223 72589 6:133124588 98127

ENSG00000150627 :WDR17 :chr4 :+: 177 ENSG00000114062:UBE3A:chrl5:- ENSG00000132716:DCAF8:chrl:- 067145 : 177067310: 177063220: 1770692 :25650607:25650649:25620910:256 : 160213749: 160213824: 160210160: 83 83635 160232238 ENSG00000204536:CCHCRl:chr6:

ENSG00000135541:AHIl:chr6:-

ENSG00000205336:ADGRGl:chrl6:+:5 :31116394:31116505:31113585:311 : 135816676: 135816847: 135813429:

7675498:57675620:57662714:57684164 17842 135816951

ENSG00000189339:SLC35E2B:chr

1:- ENSG00000204463:BAG6:chr6:-

ENSG00000124588:NQ02:chr6:+:30047 : 1602947: 1603068: 1599911:160690 :31607276:31607423 :31607003 :316

28:3004885:3004023:3006701 1 07975

ENSG00000114779:ABHD14B:chr

ENSG00000091129:NRCAM:chr7:- 3:- ENSG00000140995:DEF8:chrl6:+: : 107807365: 107807518: 107800937: 1078 :52005475:52005908:52004200:520 90015972:90016046:90015222:9002 08721 07980 0650

ENSG00000152348:ATG10:chr5:+: ENSG00000149925:ALDOA:chrl6:

ENSG00000105662:CRTCl:chrl9:+:188 81460217:81460356:81283497:8147 +:30077196:30077248:30075826:30

54917:18854965:18853836:18856632 4308 078554

ENSG00000224924 :LINC00320 :chr

ENSG00000116095 :PLEKHA3 :chr2:+: 1 21:- ENSGOOOOO 127603 :MACF1 :chrl :+: 79353694:179353741:179350484:17935 :22154624:22154764:22153979:221 39893632:39893959:39893286:3989 5385 75312 4913

ENSG00000118454:ANKRD13C:ch

ENSG00000151692:RNF144A:chr2 rl>

ENSG00000142875:PRKACB:chrl:+:84 :+:7137046:7137192:7081278:7154 :70736538:70736639:70728530:707

640715:84640739:84630696:84644859 584 42447

ENSGOOOOO 158296 : SLC 13 A3 : chr2

ENSG00000159314:ARHGAP27:chrl7:- 0:- ENSG00000100325:ASCC2:chr22:-

:43481634:43481700:43481462:4348181 :45228609:45228676:45224981 :452 :30221610:30221769:30221246:302

0 39084 28233

ENSG00000068400 : GRIP AP 1 : chrX

ENSG00000116991 :SIPAlL2:chrl :- ENSG00000073670: AD AMI 1 :chrl :232539870:232539924:232539317:2325 :48838206:48838284:48838103:488 7:+:42853494:42853575:42852833: 51239 39390 42854112

ENSG00000178104:PDE4DIP:chrl: ENSG00000169359:SLC33Al:chr3:

ENSG00000160818:GPATCH4:chrl:- : 156567826: 156567913: 156566270: 1565 : 144859758: 144859998: 144857728: : 155551645: 155551830: 155547692: 68018 144863317 155560220

ENSG00000185864 :NPIPB4 :chrl 6 : - ENSG00000184277:TM2D3 :chrl5 :- ENSG00000122481:RWDD3:chrl:+

:21868900:21868979:21868737:2187510 : 102191898: 102191976: 102190364: :95709766:95710271:95699871:957

3 102192473 12311

ENSG00000076555:ACACB:chrl2:+:10 ENSG00000198722:UNC13B:chr9: ENSG00000128683:GADl:chr2:+:l

9683983:109684253:109683553:109687 +:35401947:35402004:35400440:35 71699078:171699158:171693393:17

788 403163 1700554

ENSG00000072422:RHOBTBl:chrl0:- ENSG00000083535:PIBFl:chrl3:+: ENSG00000133619:KRBAl:chr7:+: :62631942:62632048:62631409:6263471 73547728:73547813:73505405:7357 149416636:149416763:149412157:1

1 2959 49417098

ENSG00000166169:POLL:chrl0:- ENSG00000068120 :COASY:chrl7 : ENSGOOOOO 103121 : CMC2 : chrl 6 : - : 103344358: 103344676: 103343438: 1033 +:40717000:40717065:40716595:40 :81031889:81031956:81031034:810 46878 717244 40338

ENSG00000215252:GOLGA8B:chr ENSG00000196295:AC005154.6:ch

15:- r7>

ENSG00000099917:MED15:chr22:+:20 :34867025:34867115:34846157:348 :30590933:30591095:30590397:306

929399:20929519:20922918:20936897 75716 01081

ENSG00000163939:PBRMl:chr3:- ENSG00000125952:MAX:chrl4:-

ENSG00000132670 :PTPRA:chr20 :+:295 :52592264:52592429:52584833:525 :65568263 :65568290:65560533 :655

5860:2955887:2945848:2967410 95782 69021

ENSG00000185347:C14orf80:chrl4:+:l ENSG00000102921 :N4BP1 :chrl6:-

05962216:105962423:105960270:10596 :48585296:48585393:48577172:485 ENSG00000125826:RBCKl:chr20:

3693 87449 +:390473:390669:389423:391055

ENSG00000168958:MFF:chr2:+:22 ENSG00000104936:DMPK:chrl9:-

ENSG00000117114:ADGRL2:chrl :+:82 8217229:228217289:228207535:228 :46274228:46274314:46273898:462 418670:82418709:82417826:82421560 220392 74825

ENSG00000152154:TMEM178A:ch ENSGOOOOO 120742 : SERP 1 : chr3 : -

ENSG00000101335:MYL9:chr20:+:351 r2:+:39934188:39934326:39931334: : 150284687: 150284893: 150264859:

76434:35176596:35173471:35177479 39944149 150320730

ENSG00000167106:FAM102A:chr9

ENSG00000005243 :C0PZ2 :chrl7 : - ENSG00000130023 :ERMARD:chr6 :46110051:46110107:46109599:4611122 :+: 170173414: 170173498: 17016980 : 130716083: 130716204: 130708032: 8 9:170176035 130742270 ENSG00000183474:GTF2H2C:chr5 ENSG00000160957 :RECQL4 :chr8 :-

ENSG00000183044:ABAT:chrl6:+:880 :+:68863979:68864034:68862880:6 : 145737284: 145737450: 145737172:

7475:8807722:8806919:8829555 8868271 145737526

ENSG00000148925:BTBD10:chrll

ENSG00000075292 :ZNF638 :chr2 :+

ENSG00000133816:MICAL2:chrll:+:l : 13466570: 13466728: 13443385: 134 :71575882:71577401:71559005:715

2277189:12277297:12257792:12278331 84638 82848

ENSG00000214941:ZSWIM7:chrl7

ENSG00000115239: ASB3:chr2:- ENSG00000096746:HNRNPH3:chr

:53992513:53992722:53978078:5401395 : 15880892: 15881014: 15880406: 158 10:+:70097614:70097753 :70097090

7 81113 :70098259

ENSG00000178026:LRRC75B:chr2 ENSG00000184867: ARMCX2 :chrX

2:-

ENSG00000100722:ZC3H14:chrl4:+:89 :24984646:24985233:24984297:249 : 100913446: 100913555: 100913128: 063077:89063152:89044484:89073586 85788 100914061 ENSG00000160991:ORAI2:chr7:+:1020 ENSG00000160124:CCDC58:chr3:- ENSG00000090554:FLT3LG:chrl9: 76676 : 102076780 : 102074108: 10207939 : 122084182: 122084313: 122081874: +:49982219:49982304:49979823 :49 0 122084411 983554

ENSG00000079819:EPB41L2:chr6:

ENSG00000183458:RP11- ENSG00000158806:NPM2:chr8:+:2 958N24.1:chrl6:+: 15013719: 15013940:1 : 131190951:131191266: 131186774: 1893868:21894037:21892055:21894 5013285:15014128 131206235 148 ENSG00000064787 :BCAS 1 :chr20: - ENSG00000170653:ATF7:chrl2:- ENSG00000122678 :POLM:chr7 : - :52573970:52574036:52570234:5259192 :53910798:53911138:53901811:539 :44113996:44114129:44113624:441 7 17059 16107

ENSG00000100813: ACINI :chrl4:- ENSG00000184939:ZFP90:chrl6:+: ENSG00000196498 :NCOR2 :chrl2 :- :23559190:23559310:23551045:2355973 68573660:68573728:68567758:6859 : 124941651:124941708: 124934413: 0 1900 124950718

ENSG00000160688:FLADl:chrl:+:1549 ENSG00000119684:MLH3:chrl4:- ENSG00000175267:VWA3A:chrl6:

62035:154962183:154961325:15496263 :75506613:75506718:75505115:755 +:22157556:22157665:22153013:22

4 13078 159482

ENSG00000104059:FAM189Al:chr

ENSG00000131148:EMC8:chrl6:- ENSG00000015479:MATR3:chr5:+ 15:-

:85813984:85814079:85813473:8581481 :138642927:138644016:138629494: :29488633:29488768:29429397:295

6 138651385 44571

ENSG00000150433:TMEM218:chr

ENSG00000179195:ZNF664:chrl2:+:12 11 ENSG00000068903 : SIRT2 :chrl 9:- 4489424: 124489482: 124472685 : 124495 : 124972027 : 124972213 : 124971199: :39389018:39389065:39384167:393 927 124972532 90145

ENSG00000064607:SUGP2:chrl9:- ENSG00000067208 :EVI5 :chrl :- ENSG00000198453 :ZNF568 :chrl 9: : 19104456: 19104549: 19101958: 1910517 :93073137:93073284:93070959:930 +:37422454:37422547:37416160:37 4 89732 427647

ENSG00000145428:RNF175:chr4:- ENSG00000089818:NECAPl:chrl2

ENSG00000163681:SLMAP:chr3:+:578 : 154633626: 154633728: 154631641: :+:8244435:8244446:8242895:8245

57362:57857425:57850584:57875767 154636680 271

ENSG00000166897:ELFN2:chr22:- ENSG00000181163 :NPM1 :chr5 :+: 1 ENSGOOOOO 111907:TPD52L 1 :chr6 :

:37813807:37813958:37772036:3782291 70817054:170817134:170815010:17 +: 125578243: 125578304: 125574901

0 0818308 :125583979

ENSG00000107290:SETX:chr9:- ENSG00000196776:CD47:chr3:-

ENSG00000156256:USP16:chr21:+:303 : 135144789: 135144876: 135140372: : 107768465: 107768498: 107766139:

98029:30398092:30397098:30400193 135145001 107770785

ENSG00000136153:LM07:chrl3:+: ENSG00000164548:TRA2A:chr7:-

ENSG00000070501 :POLB :chr8 :+:42206 76381615:76382335:76378677:7638 :23570799:23570889:23561459:235 533:42206608:42202537:42213033 3289 71407

ENSG00000233639 :LINCO 1158 :chr

ENSG00000143537:ADAM15:chrl:+:15 2:- ENSG00000071054:MAP4K4:chr2:

5034379:155034451:155032450:155034 : 105429166: 105429242: 105424301: +: 102477286: 102477448: 102476326

720 105469567 : 102480282

ENSG00000072803 :FBXW11 :chr5 :

ENSG00000085733 :CTTN:chrl 1 :+:7026 : 171341346: 171341409: 171337801: ENSG00000130731:METTL26:chrl 6505:70266616:70265962:70269045 171384600 6:-:685517:685774:684797:686093 ENSG00000077232 :DNAJC 10 : chr2 : +: 1 ENSG00000108799:EZHl:chrl7:- ENSG00000148180:GSN:chr9:+:12 83600975:183601113:183597269:18360 :40876322:40876442:40874933:408 4062333:124062404:124048463:124 5025 79652 064240 ENSG00000243156 :MICAL3 :chr22

ENSG00000177879:AP3Sl:chr5:+:l

ENSG00000004660:CAMKKl:chrl7:- :18310409:18310547:18304936:183 15242517:115242558:115238689:11

:3784920:3784942:3783728:3786335 14619 5247785

ENSG00000176155:CCDC57:chrl7

ENSG00000143537:ADAM15:chrl:+:15 ENSG00000058673 :ZC3H11 A:chrl

5033890:155033965:155033308:155034 :+:203803064:203803230:20380298 :80136902:80137065:80136481:801

720 1:203807093 41649

ENSG00000108509:CAMTA2:chrl

7:- ENSG00000161647:MPP3:chrl7:-

ENSG00000198858 :R3HDM4 :chrl 9:- :4885383:4885455:4884654:488605 :41898229:41898426:41895478:419 :901419:901546:900952:901975 1 01298

ENSG00000148660:CAMK2G:chrl

ENSG00000115657:ABCB6:chr2:- 0:-

:220082391:220082529:220081554:2200 :75579289:75579403:75577312:755 ENSG00000110811 :P3H3 :chrl2:+:6

82846 81439 940033:6940197:6939934:6940379

ENSG00000204371 :EHMT2 : chr6 : - ENSG00000242086 :LINC00969 :chr ENSG00000226711 :FAM66C:chrl2 :31861138:31861439:31860687:3186403 3 :+: 195389441: 195389604: 1953850 :+:8346115:8346251:8341241:8346 9 36:195390956 798

ENSG00000101928:MOSPDl:chrX:- ENSG00000143207:RFWD2:chrl:- ENSG00000163754:GYG1 :chr3 :+: 1 : 134025508: 134025670: 134023222: 1340 : 176104145: 176104222: 176085817: 48744238:148744289:148742059:14 30846 176118141 8744546

ENSG00000152578:GRIA4:chrll:+:105 ENSG00000139974:SLC38A6:chrl ENSG00000100461:RBM23:chrl4:-

836673:105836788:105804695:1058450 4:+:61510167:61510221:61509930: :23378691:23378804:23375577:233

36 61512063 88207

ENSG00000169064:ZBBX:chr3:- ENSG00000100387:RBXl:chr22:+: ENSG00000186998:EMIDl:chr22:+ : 167006654: 167006771 : 167000283 : 1670 41360050:41360121:41347480:4136 :29621121:29621205:29611619:296 16092 8479 27008

ENSG00000111879:FAM184A:chr6

ENSG00000168894:RNF181:chr2:+

ENSG00000164190 :NIPBL : chr5 : +: 3703 :85823979:85824054:85823772:858 : 119281933: 119282028: 119281349: 6480:37036589:37027514:37044448 24226 119282925

ENSG00000087087 : SRRT:chr7:+: 1 ENSG00000144285:SCNlA:chr2:-

ENSG00000126777 :KTN1 :chrl4 :+: 5611 00480385 : 100480711 : 100479862: 10 : 166858981 : 166859263 : 166856286: 7286:56117355:56117136:56118607 0481690 166866228

ENSG00000197302:ZNF720:chrl6:

ENSG00000119139 :TJP2 :chr9 :+:718642 ENSG00000139197:PEX5:chrl2:+: +:31744831:31744948:31734674:31

90:71864401:71863140:71865950 7342617:7342812:7342346:7342957 765086

ENSG00000110074:FOXREDl:chrll:+: ENSG00000126705:AHDCl:chrl:- ENSG00000144134:RABL2A:chr2:

126144825:126144916:126143349:1261 :27884815:27885041:27861427:278 +: 114398932: 114399027: 114391809

45221 85216 : 114399357

ENSG00000131089:ARHGEF9:chr

ENSG00000091972 : CD200 :chr3 :+: X:-

ENSG00000135740:SLC9A5:chrl6:+:67 112059748: 112059830: 112052071 : 1 :62974183 :62974556:62944591 :629

296114:67296192:67293849:67298254 12063808 74800

ENSG00000065600:TMEM206:chrl:- ENSG00000175575 :PAAF1 :chrl 1 :+ ENSG00000139323:POClB:chrl2:-

:212548534:212548642:212538718:2125 :73598084:73598144:73589864:735 :89818937:89819156:89815034:898

50903 98398 53414

ENSG00000166405 :RIC3 :chrl 1 ENSG00000215154:AC141586.5:ch

ENSG00000116819:TFAP2E:chrl:+:360 :8148205:8148354:8132684:815892 rl6:+:2660462:2661053:2653728:26

53930:36054153:36040601:36055530 4 63960

ENSG00000180881:CAPS2:chrl2:- ENSG00000173210:ABLIM3:chr5:

ENSG00000188730:VWC2:chr7:+:4981 :75683400:75683555:75678860:756 +: 148620238: 148620337: 148619451

4928:49815727:49813709:49842306 85523 : 148622053

ENSG00000114062:UBE3A:chrl5:- ENSG00000100325:ASCC2:chr22:-

ENSG00000014641:MDHl:chr2:+:6382 :25652213 :25652284:25650649:256 :30228233:30228331:30221246:302

1621:63821720:63816518:63824532 83635 34166

ENSG00000150401:DCUNlD2:chr

ENSG00000095637:SORBSl:chrl0:- 13:- ENSG00000142949:PTPRF:chrl:+:

:97135729:97135813:97127456:9714144 :114138154:114138511:114135058: 44069281:44069860:44069204:4407

1 114144981 0573

ENSG00000113761 :ZNF346 : chr5 :+ : 176 ENSG00000065609 : SNAP91 :chr6 :- ENSGOOOOO 162402 :USP24 : chrl : - 477703:176477937:176471534:1764890 :84324575 :84324581:84320396:843 :55550065:55550094:55549561:555 58 26687 51614

ENSG00000097033 : SH3 GLB 1 :chrl ENSG00000182944:EWSRl:chr22:

ENSG00000103197:TSC2:chrl6:+:2127 :+:87195770:87195794:87190088:8 +:29670253 :29670271 :29669853 :29

598:2127727:2126586:2129032 7200284 674018 ENSG00000109466:KLHL2:chr4:+: ENSG00000164211 : ST ARD4 :chr5 : -

ENSG00000215039:CD27-ASl:chrl2:- 166242463 : 166242527 : 166239121 : 1 : 110837659: 110837786: 110836814: :6557202:6557316:6556253 :6560634 66243183 110842027 ENSG00000171307:ZDHHC16:chrl0:+: ENSG00000133816 :MICAL2 xhrl 1 ENSG00000122417:ODF2L:chrl:- 99213555:99213603:99212260:9921447 :+: 12262586: 12262709: 12261132:1 :86847924:86848041:86842101:868 0 2270730 48613

ENSG00000071462 :WB SCR22 xhr ENSG00000165795:NDRG2:chrl4:-

ENSG00000183077 : AFMID :chrl7 :+:76 7:+:73098096:73098330:73098003: :21486615:21486630:21486398:214 200908:76200981:76198832:76202991 73106925 86921

ENSG00000185838:GNBlL:chr22:- ENSG00000003987 :MTMR7 : chr8 : -

ENSG00000118900:UBNl:chrl6:+:4927 : 19794181: 19794280: 19789739: 198 : 17188658: 17188791: 17170910: 171

385:4927475:4927112:4930083 41965 98871

ENSG00000040199:PHLPP2:chrl6:

ENSG00000145725 :PPIP5K2 :chr5 :+: 10 ENSG00000138674 : SEC31 A:chr4 : - 2523014:102523077:102522140:102526 :71718378:71718504:71715808:717 :83819141:83819215:83803093:838 542 24421 21229

ENSG00000145349:CAMK2D:chr4

ENSG00000101040:ZMYND8:chr20:- ENSG00000074266 :EED xhrl 1 :+: 8

:45867501:45867882:45865260:4587803 :114426131:114426191:114421667: 5968556:85968638:85967554:85988

0 114430793 021

ENSG00000148341:SH3GLB2:chr9

ENSG00000115109:EPB41L5:chr2:+:12 ENSG00000151690:MFSD6:chr2:+:

0925452:120925583:120925083:120932 191280017:191280139:191273229:1 : 131775286: 131775298: 131772972:

416 91300702 131776689

ENSG00000080823:MOK:chrl4:- ENSG00000086666 :ZFAND6 xhrl 5 ENSG00000162444 :RBP7 xhrl :+: 1 : 102698043: 102698158: 102695994: 1027 :+:80412669:80412840:80352151:8 0067627:10067806:10057389:10068 00024 0423521 230

ENSG00000167333:TRIM68:chrll:

ENSG00000244754 :N4BP2L2 :chrl 3 :- ENSG00000186088:GSAP:chr7:- :33109905 :33111164:33101669:3311275 :4626308:4626791 :4624570:462925 :76982888:76983012:76982343:769 4 6 84529

ENSG00000169255:B3GALNTl:chr3:- ENSG00000137817:PARP6:chrl5:- : 160818926: 160819021: 160804576: 1608 :72543185:72543295:72542433:725 ENSG00000185615:PDIA2:chrl6:+: 21214 43547 335311:335437:335015:335505

ENSG00000159363:ATP13A2:chrl:

ENSG00000204623:ZNRDlASP:chr6:- ENSG00000105792:CFAP69:chr7:+

:30002684:30002887:29989538:3000369 :89915594:89915713:89912370:899 : 17316381: 17316498: 17316265: 173

2 17547 16621

ENSG00000118495 :PLAGLl:chr6:- ENSG00000147099:HDAC8:chrX:-

ENSG00000163629:PTPN13:chr4:+:876 : 144269121: 144269597: 144263800: :71710778:71710856:71708891:717

14739:87614827:87610343:87622393 144281605 15005

ENSG00000185046:ANKSlB:chrl2

ENSG00000136754:ABIl:chrl0:- ENSG00000166889:PATL1 xhrl 1 :-

:27060003:27060018:27059274:2706599 :59423428:59423518:59423213:594 : 99201621 : 99201696:99194903:992

3 23971 22951

ENSG00000088280 : AS AP3 xhrl : - ENSG00000204580:DDRl:chr6:+:3 ENSG00000099290:WASHC2A:chr :23768147:23768212:23767966:2376867 0853401:30853457:30850760:30856 10:+:51885816:51885939:51885209 8 464 :51887342

ENSG00000068120 :C0ASY:chrl7 : ENSG00000231584:FAHD2CP:chr2

ENSG00000141452:C18orf8:chrl8:+:21 +:40716726:40716916:40716595:40 :+:96684948:96685008:96681073:9

089156:21089243:21084411:21095819 717000 6685285

ENSGOOOOO 196118: CCDC189 xhrl

ENSG00000158987 :RAPGEF6:chr5 : - ENSG000001291 16 PA1 J,Dxhr4 +· 6:- : 130764594: 130764909: 130762984: 1307 169817699:169817750:169815828:1 :30770498:30770568:30768975:307 66551 69819643 70662

ENSG00000132780:NASP:chrl:+:4 ENSG00000124440:HIF3A:chrl9:+:

ENSG00000204580:DDRl:chr6:+:30852 6082372:46082375:46082065:46083 46815762:46815910:46815524:4682 314:30852487:30850942:30856464 134 3699 ENSG00000064607:SUGP2:chrl9:- ENSG00000160469:BRSKl:chrl9: ENSG00000171723:GPHN:chrl4:+: : 19104446: 19104549: 19101958: 1910517 +:55815417:55815478:55815194:55 67452398:67452455:67432042:6749

4 815918 0349

ENSG00000257337:RP11-

ENSG00000158796 :DEDD xhrl : - 983P16.4:chrl2:-

ENSG00000004866:ST7:chr7:+: 1168301 : 161100604: 161100633: 161094316: :53439383 :53439437:53434047:534 86:116830322:116829447:116830887 161102340 39744 ENSG00000135454:B4GALNTl:chrl2:- ENSG00000160216:AGPAT3:chr21 ENSG00000156299:TIAMl:chr21:- :58024982:58025147:58024869:5802569 :+:45323837:45323900:45285226:4 :32649047:32649224:32639299:327 7 5379514 11557

ENSG00000143549:TPM3:chrl:- ENSGOOOOO 114062 :UBE3 A:chrl 5 : -

ENSG00000102312:PORCN:chrX:+:483 : 154143888: 154143964: 154143187: :25652213:25652375:25650649:256

72514:48372529:48371107:48372627 154145383 54234

ENSG00000038532:CLEC16A:chrl ENSGOOOOO 118705 :RPN2 :chr20 :+:

ENSG00000088367 :EPB41L 1 :chr20 :+: 3 6:+: 11066410: 11066416: 11065087: 35866804:35866852:35865112:3586 4802281:34802362:34800298:34806797 11066794 9705 ENSG00000110076 :NRXN2 :chrl 1 :- ENSG00000115464 :USP34:chr2:- ENSG00000102125:TAZ:chrX:+:15 :64393934:64394024:64390550:6439787 :61430274:61430398:61420115:614 3642437:153642527:153641904:153

3 31631 647881

ENSG00000004455:AK2:chrl:- ENSG00000165661:QSOX2:chr9:-

ENSG00000170871:KIAA0232:chr4:+:6 :33497144:33497262:33487304:335 : 139115608: 139115699: 139111010:

860151:6860233:6843931:6862627 02336 139115852

ENSG00000173706:HEGl:chr3:- ENSG00000071994 :PDCD2 :chr6 :-

ENSG00000278535:DHRSll:chrl7:+:34 : 124729282: 124729399: 124728668: : 170889089: 170889193: 170888058: 951456:34951610:34948586:34954591 124731466 170892144 ENSG00000171163 :ZNF692:chrl :- ENSG00000135250:SRPK2:chr7:- ENSGOOOOO 140474 :ULK3 :chrl 5 : - :249150571:249150621:249150145:2491 : 104766694: 104766787 : 104758469: :75130091:75130139:75129776:751 51432 104773237 30606

ENSG00000137504:CREBZF:chrll

ENSG00000010803 :SCMH1 :chrl :- ENSG00000115504 :EHBPl:chr2:+: :41625396:41625605:41608784:4162654 :85372680:85372793:85371641:853 63085540:63085645:63058293:6308 6 73432 6303

ENSG00000160323 : ADAMTS13 :ch ENSG00000138101:DTNB:chr2:-

ENSG00000137764 :MAP2K5 :chrl 5 :+:6 r9:+: 136323031:136323216: 136321 :25642383 :25642404:25611230:256 8020253 :68020283 :67995746:68040906 841:136324095 50403

ENSG00000005194:CIAPINl:chrl6 ENSG00000088876:ZNF343:chr20:

ENSG00000168118:RAB4A:chrl:+:229

422232:229422313:229407117:2294315 :57465062:57465178:57464251:574 :2474164:2474223:2473471:248130

94 66398 1

ENSG00000114062 :UBE3 A:chrl 5 : - ENSG00000068724:TTC7A:chr2:+: ENSG00000125804:FAM182A:chr2 :25652213:25652359:25650649:2565423 47249000:47249118:47238574:4725 0:+:26054405:26054505:26049840:

4 6362 26061799

ENSG00000073921 :PICALM:chrl 1

ENSG00000115216:NRBPl:chr2:+:

ENSG00000090661:CERS4:chrl9:+:831 :85689112:85689136:85685855:856 27658589:27658613:27658094:2765

5993:8316133:8274378:8319382 92171 9619

ENSG00000153066:TXNDCll:chr ENSGOOOOO 118160 : SLC8 A2 : chrl 9 :

ENSG00000176095:IP6Kl:chr3:- 16:-

:49785250:49785601:49775855:4982378 : 11815432: 11815526: 11792181: 118 :47944593:47944697:47941230:479

6 27837 51065

ENSG00000188859:FAM78B:chrl> ENSG00000181045:SLC26All:chr ENSGOOOOO 152952 :PL0D2 :chr3 :-

: 166039071 : 166040000: 166029900: 1661 17:+:78221928:78222056:78220448 : 145795648: 145795711 : 145791139: 35222 :78225127 145796902

ENSG00000116731:PRDM2:chrl:+ ENSGOOOOO 115942 : 0RC2 :chr2 : -

ENSG00000006042 :TMEM98 :chrl7 :+: 3 : 14099572: 14099683: 14075982: 141 :201790558:201790655:201785862: 1258344:31258420:31255255:31258492 42921 201796061

ENSG00000183087:GAS6:chrl3:- ENSG00000089157:RPLP0:chrl2:-

ENSG00000134452:FBXO18:chrl0:+:59 : 114549499: 114549562: 114542823 : : 120636356: 120636573: 120635265: 47180:5947250:5945138:5947999 114566547 120636656 ENSG00000102977:ACD:chrl6:- ENSG00000137656:BUD13 :chrl 1 :- ENSGOOOOO 196781 :TLE1 :chr9: - :67692457 :67692544:67692265 :6769262 : 116629789: 116629895 : 116628666: :84268888:84268951:84249216:843 2 116631450 00590

ENSG00000076555:ACACB:chrl2:+:10 ENSG00000152726:FAM21B:chrl0 ENSGOOOOO 170322:NFRKB :chrl 1 :- 9654422: 109654511 : 109650741 : 109660 :+:47926002:47926172:47922366:4 : 129747219: 129747280: 129746790: 311 7929794 129748205

ENSG00000111961: S ASH1 :chr6 :+: 1487 ENSG00000171723:GPHN:chrl4:+: ENSGOOOOO 152620:NADK2 :chr5 :- 61493 : 148761543 : 148711398: 14878968 67390910:67391009:67389655:6743 :36208726:36208792:36207367:362 0 1907 11945

ENSG00000152520:PAN3:chrl3:+: ENSG00000078403:MLLT10:chrl0

ENSG00000090060 :PAPOL A:chrl4 :+: 9 28771321:28771483:28752072:2879 :+:21971153:21971186:21970305:2 7026985:97027048:97022750:97029155 4367 2002700 ENSG00000090238:YPEL3:chrl6:- ENSG00000156976:EIF4A2:chr3:+: ENSG00000153975:ZUFSP:chr6:- :30106318:30106467:30106218:3010657 186506098:186506205:186505671:1 : 116987796: 116988075: 116982009: 2 86506913 116989728 ENSGOOOOO 137871 :ZNF280D :chrl

ENSG00000135446:CDK4:chrl2:- 5:-

ENSG00000168487:BMPl:chr8:+:22049 :58145282:58145535:58145125:581 :56999279:56999341:56996465:569

747:22049848:22049664:22051570 45957 99460

ENSG00000006128 : TAC 1 : chr7 : +: 9 ENSG00000135097:MSIl:chrl2:-

ENSG00000118473 :SGIP1 :chrl :+:67099 7365610:97365664:97364161:97369 : 120805810: 120805895: 120802558: 762:67099846:67098777:67105459 185 120806635

ENSG00000111679:PTPN6:chrl2:+ ENSG00000166387:PPFIBP2:chrll

ENSG00000188157:AGRN:chrl:+:9873 :7067081 :7067236:7066948:706908 :+:7662263 :7662296:7661101 :7662

72:987396:987195:988840 9 709

ENSG00000114859:CLCN2:chr3:- ENSG00000157445:CACNA2D3:ch

ENSG00000163995:ABLIM2:chr4:- : 184075407: 184075486: 184075275: r3:+:54913376:54913438:54913116:

:7994592:7994654:7985071:8009785 184075749 54914822

ENSG00000136643:RPS6KCl:chrl:+:21 ENSG00000167549:COR06:chrl7:- ENSG00000068650:ATPllA:chrl3:

3405465:213405598:213349835:213414 :27946077:27946207:27945989:279 +: 113532530: 113532617: 113530255

044 48241 : 113536189

ENSG00000163875 :MEAF6:chrl :- ENSG00000153207 : AHCTF1 : chrl : - ENSG00000125462:Clorf61:chrl:- :37962307:37962337:37961519:3797487 :247007096:247007230:247004300: : 156376871: 156376989: 156374393: 8 247012916 156383204

ENSG00000248019:FAM13A- ENSG00000182796:TMEM198B:ch ENSG00000139631:CSAD:chrl2:-

ASl:chr4:+:89643301:89643495:896331 rl2:+:56226742:56226798:5622513 :53554910:53554975:53554103:535

68:89644359 3:56227230 55056

ENSG00000136717:BINl:chr2:- ENSG00000161395:PGAP3:chrl7:- : 127808729: 127808819: 127808488: 1278 :37829303:37829508:37829119:378 ENSG00000169598:DFFB:chrl:+:3 15048 30245 782847:3782962:3782564:3784537

ENSG00000003509 :NDUFAF7 :chr ENSG00000008226:DLEC1 :chr3 :+:

ENSG00000266714:MY015B:chrl7:+:7 2:+:37469777:37469836:37468780: 38161938:38162100:38159515:3816 3610061:73610114:73609858:73610279 37471005 3118 ENSG00000131373:HACLl:chr3:- ENSG00000146556:WASH2P:chr2: : 15628031:15628109: 15624496: 1563104 +: 114352639: 114352738: 11434628 ENSG00000124588:NQ02:chr6:+:3 6 0:114352945 004728:3004885:3000319:3006701

ENSG00000244560 :RP4- ENSG00000138400:MDHlB:chr2:-

ENSG00000109046:WSBl:chrl7:+:2562 800G7.2:chr7:+: 148987028: 148987 :207615657:207615799:207613907:

8906:25628982:25621461:25630392 129:148984867:148989301 207619732 ENSG00000003756 :RBM5 :chr3 :+: 5 ENSG00000129351:ILF3:chrl9:+:l

ENSG00000183597 :TANG02 :chr22 :+:2 0147811:50147896:50147121:50148 0791021:10791119:10790603:10791 0040882:20041074:20040107:20043465 111 694

ENSG00000112357 :PEX7:chr6:+:l ENSG00000104529:EEFlD:chr8:-

ENSG00000205250:E2F4:chrl6:+:67227 37187764:137187871:137147607:13 : 144674816: 144674830: 144672251 :

324:67227418:67226773:67228300 7191027 144679517

ENSG00000268790:CTC- ENSGOOOOO 189339: SLC35E2B :chr

ENSG00000109065 :NAT9 :chrl7: - 429P9.4:chrl9:- 1:- : 72771737 :72771846 :72769824 : 7277240 : 16770765 : 16770811 : 16770258: 167 : 1622414: 1622832: 1608285 : 162388 5 70895 7

ENSG00000142920:AZIN2:chrl:+: ENSG00000175287:PHYHDl:chr9:

ENSG00000099219 :ERMP1 :chr9 :- 33548618:33548743:33547955:3354 +: 131700035: 131700223: 131698924 :5805610:5805785:5801328:5810010 9554 : 131703723

ENSGOOOOO 166762 : C ATSPER2 :chr

ENSG00000189046 : ALKBH2 :chrl2 :- 15:- ENSG00000125814:NAPB:chr20:- : 109527813 :109528012: 109526317:1095 :43956615:43956741:43942077:439 :23375775:23375822:23375636:234 30311 60225 01941

ENSG00000203791:METTL10:chrl

ENSG00000107521:HPSl:chrl0:- 0:-

ENSG00000132591:ERALl:chrl7:+:271 : 100190887: 100191048: 100190427: : 126477607: 126477726: 126463351 :

85593:27185651:27185504:27185981 100193696 126480292

ENSG00000148925:BTBD10:chrll:

ENSG00000105323:HNRNPULl:ch

ENSG00000106125:MINDY4:chr7:+:30 rl9:+:41811736:41811772:4181016 : 13466570: 13466728: 13443385: 134

891831:30891895:30890171:30893009 6:41812353 84646

ENSG00000161914:ZNF653:chrl9:

ENSG00000115289:PCGFl:chr2> ENSG00000143207:RFWD2:chrl:-

:74732863:74732897:74732546:7473307 : 11611492: 11611630: 11609154: 116 : 176145045: 176145143: 176104222:

8 16302 176153768

ENSG00000159322:ADPGK:chrl5:

ENSG00000140521:POLG:chrl5:- :89861169:89861268:89860767:8986177 ENSG00000010379:SLC6A13:chrl :73047896:73047995:73045233:730 1 2:-:336730:336834:332400:344255 64123 ENSG00000110888:CAPRIN2:chrl

ENSG00000154114:TBCEL:chrll:+:120 ENSG00000068796 :KIF2 A:chr5 :+: 2:-

924259:120924441:120918376:1209257 61668264:61668378:61661180:6166 :30886562:30886645:30883216:308

60 9513 87901

ENSG00000168890:TMEM150A:ch

ENSG00000148180:GSN:chr9:+:12 r2:-

ENSG00000144741 : SLC25 A26 :chr3 :+:6 4062333:124062404:124030497:124 :85827467:85827535:85827141:858 6286967:66287124:66271553:66312474 064240 28143 ENSG00000105486:LIGl:chrl9:- ENSG00000117308:GALE:chrl:- ENSG00000214575:CPEBl:chrl5:- :48665518:48665608:48664764:4866880 :24125376:24125502:24125220:241 :83295943:83296118:83240282:833 6 25855 15959

ENSG00000167302:TEPSIN:chrl7:

ENSG00000095203:EPB41L4B:chr9:- ENSG00000187391:MAGI2:chr7:- : 111947768:111947885: 111945077:1119 :79206114:79206318:79205821 :792 :77814945:77814987:77807419:778 54557 07231 24190

ENSG00000168754:FAM178B:chr2

ENSG00000070061 : KBKAP: chr9 : - ENSG00000169062:UPF3A:chrl3:+ : 111681532:111681629: 111679950:1116 : 115056963: 115057019: 115052104: :97594942:97595057:97589320:976 85121 115057108 13554

ENSG00000204536:CCHCRl:chr6:- ENSG00000078967 :UBE2D4 :chr7 : ENSG00000026652 : AGPAT4 :chr6 :- :31124799:31124932:31124721 :3112594 +:43967612:43967710:43966155:43 : 161587279: 161587449: 161575342: 3 978029 161653067

ENSG00000153066:TXNDCll:chr

ENSG00000143164:DCAF6:chrl:+:1679 16:- ENSG00000198176:TFDPl:chrl3:+ 92225 : 167992285 : 167974031 : 16801226 : 11827837: 11827935: 11815526: 118 : 114292132: 114292211:114291015: 2 29872 114294434

ENSG00000125954:CHURC1- ENSG00000093000 :NUP50 :chr22 :+ ENSG00000185133:INPP5J:chr22:+

FNTB:chrl4:+:65392724:65392798:653 :45571774:45571961:45567564:455 :31520830:31520892:31519105:315

90844:65479034 77166 21818

ENSG00000001460:STPGl:chrl:- ENSG00000170632:ARMC10:chr7: ENSG00000090097:PCBP4:chr3:-

:24718413:24718557:24718169:2472780 +:102727315: 102727384: 10272721 :51996825:51996908:51996104:520

8 1:102737723 01341

ENSG00000150471:ADGRL3:chr4: ENSG00000146733:PSPH:chr7:-

ENSG00000156502:SUPV3Ll:chrl0:+:7 +:62894572:62894599:62863983:62 :56101073:56101187:56099747:561

0954943:70955021:70951522:70958127 897159 01653

ENSG00000163644:PPMlK:chr4:- ENSG00000205423 :CNEP1R1 :chrl

:89199295:89199794:89198395:8920555 6:+:50059561:50059612:50059251: ENSG00000132199:ENOSFl:chrl8:

7 50060306 -:678695:678737:677872:683245

ENSG00000178761:FAM219B:chrl ENSG00000154493:C10orf90:chrl0

5:-

ENSG00000124440:HIF3A:chrl9:+:468 :75197322:75197400:75197053:751 : 128335133: 128335206: 128202508:

32337:46832735:46828896:46834412 97494 128358809

ENSG00000160188:RSPHl:chr21:- ENSG00000139793 :MBNL2 :chrl 3 :

ENSG00000140575:IQGAPl:chrl5:+:90 :43912867:43912973:43906571:439 +:98018712:98018807:98017425:98

974452:90974484:90972898:90976950 16242 043575

ENSG00000215041 :NEURL4:chrl7

ENSG00000139438:FAM222A:chrl2:+: ENSG00000134324:LPINl:chr2:+:l

110181905:110182033:110152702:1102 :7221813:7222010:7221675:722236 1931833:11931911:11928582:11932

05816 8 039

ENSG00000130958:SLC35D2:chr9:- ENSG00000008710 :PKD 1 :chrl6 :-

:99098998:99099066:99086451:9910618 :2166833:2167017:2166645:216748 ENSG00000189292: ALKAL2 :chr2 :

5 9 -:286122:286203:283175:286289

ENSG00000076043 :REX02 :chrl 1 :+: 11 ENSG00000025423:HSD17B6:chrl ENSG00000008394:MGSTl:chrl2: 4314577: 114314655 : 114311461 : 114320 2:+:57156981:57157198:57146365: +: 16507164: 16507204: 16500644: 16 567 57167617 516728

ENSG00000260230 ERRS 1L : chr9 : - ENSG00000160570:DEDD2:chrl9:- ENSG00000087460:GNAS:chr20:+: : 111911915:111912000: 111909469:1119 :42719284:42719404:42713992:427 57464580:57464604:57464408:5747 29180 21783 0666

ENSG00000135148:TRAFDl:chrl2:+:l ENSG00000163125 :RPRD2:chrl :+: ENSG00000080802 :CNOT4 :chr7 :- 12563888: 112563953 : 112563422: 11256 150414356:150414434:150413499:1 : 135048605: 135048818: 135047938: 8314 50415706 135078669

ENSG00000186522:SEPT10:chr2:- ENSG00000148399:DPH7:chr9:-

ENSG00000160801:PTHlR:chr3:+:4694 : 110342702: 110342898: 110332344: : 140471921: 140472055: 140470854:

4015:46944157:46943350:46944759 110350627 140473076

ENSG00000171570:RAB4B- ENSG00000115806 : GORASP2 :chr ENSG00000126214:KLCl:chrl4:+:

EGLN2:chrl9:+:41286289:41286404:41 2:+: 171811159: 171811292: 1718079 104151322:104151373:104145855:1

284296:41289825 68:171818172 04153417 ENSG00000134262:AP4Bl:chrl:- ENSG00000185324:CDK10:chrl6: ENSG00000084623:EIF3I:chrl:+:32

: 114445259:114445356: 114444507:1144 +:89755659:89755732:89753205:89 691771:32691921:32690076:326940

47226 756960 99

ENSG00000135454:B4GALNTlxhrl2:- ENSG00000203875 : SNHG5 :chr6 :- ENSGOOOOO 168502 :MTCL 1 xhrl 8 :

:58024982:58025037:58024869:5802569 :86387512:86387617:86387210:863 +:8809445:8809559:8807058:88129

7 87671 76

ENSG00000106948:AKNA:chr9:- ENSG00000117791 :MARC2:chrl :+ ENSG00000133958:UNC79:chrl4:+ : 117105987: 117106083: 117104405: 1171 :220955119:220955274:220936392: : 94044187 : 94044409 : 94041544 : 940 08142 220957260 46494

ENSG00000171311 :EX0SC1 :chrlO ENSG00000153066:TXNDCll:chrl

6:-

ENSG00000157184:CPT2:chrl:+:53678 :99202993:99203068:99201016:992 : 11824500: 11824630: 11815526: 118

452:53678488:53676991:53678935 05488 27837

ENSG00000138101:DTNB:chr2:- ENSG00000217555:CKLF:chrl6:+: ENSG00000204463:BAG6:chr6:-

:25606704:25606758:25602192:2561015 66597024:66597120:66592251:6659 :31612301:31612406:31611971:316

7 9985 12722

ENSG00000102710 : SUPT20H : chrl 3 : - ENSG00000166833 :NAV2:chrl 1 :+: ENSG00000136717:BINl:chr2:-

:37622700:37622736:37622073:3762562 20104137:20104146:20101755:2010 : 127809830: 127809938: 127808819:

4 4552 127816586

ENSG00000129657:SEC14Ll:chrl

ENSG00000165084:C8orf34:chr8:+:696 7:+:75089325:75089429:75085353: ENSG00000158270:COLEC12:chrl 88633:69688684:69633672:69699677 75138727 8:-:480706:480757:357522:500507 ENSG00000161265:U2AFlL4:chrl9:- ENSG00000008083 : JARID2:chr6:+ ENSG00000134644:PUMl:chrl:- : 36235526:36235639:36235322: 3623624 : 15410454: 15410596: 15374483: 154 :31452908:31453025:31447649:314

8 52236 54158

ENSG00000257621 :PSMA3-

ENSG00000135094:SDS:chrl2:- ENSG00000126432:PRDX5 xhrl 1 : ASlxhrU:- : 113836319:113836411:113835197:1138 +:64087205:64087340:64085858:64 :58740696:58740853:58734111:587 36916 088336 58352

ENSG00000054965:FAM168A:chrll:- ENSG00000002933 :TMEM176A:ch ENSGOOOOO 126733 :D ACH2 :chrX:+ :73136066:73136093:73131044:7314173 r7:+: 150501449: 150501573: 150500 :86082768:86082815:86071102:860 4 920:150501914 87108

ENSG00000134058:CDK7:chr5:+:6 ENSG00000125458:NT5C:chrl7:-

ENSG00000134014:ELP3:chr8:+:27954 8551286:68551355:68531280:68553 :73127139:73127200:73126737:731

735:27954835:27950750:27957344 869 27275

ENSG00000092531:SNAP23:chrl5: ENSGOOOOO 110075 :PPP6R3 xhrl 1 :

ENSG00000119777:TMEM214:chr2:+:2 +:42813811:42813906:42807552:42 +:68350510:68350597:68343511:68 7261351:27261400:27260570:27261569 820459 355394 ENSG00000115694:STK25:chr2:- ENSG00000112659:CUL9:chr6:+:4 ENSG00000140678:ITGAX:chrl6:+ :242447420:242447550:242441123:2424 3156260:43156453:43155856:43160 :31381301:31381419:31374695:313 47857 738 82404

ENSG00000283886 :RP11 -

ENSG00000170954:ZNF415:chrl9:- 204M4.3:chr9:- ENSG00000163531:NFASC:chrl:+:

:53619565:53619686:53613161:5362565 :42008850:42008960:41963942:420 204960419:204960434:204957934:2

6 18927 04966297

ENSG00000100813:ACINl:chrl4:- ENSG00000072195: SPEG:chr2 :+:2

ENSG00000112130:RNF8:chr6:+:37339 :23536522:23537880:23535217:235 20353219:220353387:220353032:22 287:37339350:37336994:37358517 38684 0353499 ENSG00000104059:FAM189Al:chrl5:- ENSG00000127603:MACFl:chrl:+ ENSG00000048028:USP28:chrl 1 :- :29443936:29444044:29429397:2954457 :39946591:39946702:39945681:399 : 113677210: 113677306: 113675768:

1 51209 113679019

ENSG00000150403 :TMC03 xhrl 3 :+: 11 ENSG00000156162:DPY19L4:chr8: ENSG00000130511:SSBP4:chrl9:+: 4201614:114201694:114193822:114202 +:95777938:95778037:95777542:95 18542162:18542228:18541740:1854 617 778839 2456

ENSG00000155329:ZCCHC10:chr5:- ENSG00000165948:IFI27Ll:chrl4: ENSG00000138036:DYNC2LIl:chr : 132335823: 132335865: 132334542: 1323 +:94567084:94567117:94563311:94 2:+:44023856:44023934:44021782: 42450 568822 44027979

ENSG00000151572:AN04:chrl2:+:1013 ENSG00000113100 : CDH9 : chr5 : - ENSG00000234745 :HL A-B :chr6: -

81316:101381448:101368667:10141381 :26886074:26886192:26885974:268 :31322883:31323000:31322442:313

1 89944 23093

ENSG00000115657: ABCB6:chr2:- ENSG00000121775:TMEM39B:chr ENSG00000148484:RSUl:chrl0 :220080718 :220080902:220079804 :2200 1:+:32542764:32542919:32541423: : 16858971 : 16859083 : 16824083 : 168 81085 32557275 59313

ENSG00000136531:SCN2A:chr2:+:1661 ENSG00000159840:ZYX:chr7:+:14 ENSG00000266714:MY015B:chrl

65861:166165953:166165304:16616683 3081182:143081338:143080415:143 7:+:73588508:73588622:73588382:

2 084854 73588759 ENSG00000118200:CAMSAP2:chrl:+:2 ENSG00000151743:AMNl:chrl2:- ENSG00000102078:SLC25A14:chr

00816385:200816420:200813997:20081 :31872151:31872290:31854941:318 X:+: 129484619: 129484705: 1294833

6767 81904 19:129492613

ENSG00000031823 :RANBP3 :chrl 9

ENSG00000100505:TRIM9:chrl4:-

ENSG00000112078 :KCTD20 :chr6 :+: 36 :5957928:5957984:5928098:597807 :51464767:51464906:51452862:514 446897:36447000:36442839:36449338 1 75797

ENSG00000136861:CDK5RAP2:ch

ENSG00000143442:POGZ:chrl:- r9:- ENSG00000163531:NFASC:chrl:+: : 151413403: 151413562: 151403317: 1514 : 123222849: 123223025: 123220900: 204955037:204955242:204953270:2 14556 123230137 04956545

ENSG00000107281:NPDCl:chr9:- ENSG00000198089:SFIl:chr22:+:3

ENSG00000175575:PAAFl:chrll:+:735 : 139935122: 139935189: 139934888: 2009127:32009202:32007826:32010

97973:73598144:73589864:73598398 139935513 774

ENSG00000165795:NDRG2:chrl4:

ENSG00000165521:EML5:chrl4:- ENSG00000163995:ABLIM2:chr4:-

:89088947:89089062:89087645:8909131 :21492144:21492255:21491480:214 :8029485:8029584:8010829:803138

3 93007 2

ENSG00000058404 : CAMK2B : chr7

ENSG00000136754:ABIl:chrl0:- ENSG00000104835:SARS2:chrl9:-

:27052808:27052889:27048167:2705414 :44273988:44274060:44270653:442 :39408560:39408648:39408473:394

6 80305 09061

ENSG00000101349:PAK5:chr20:- ENSG00000165801 : ARHGEF40 : ch

ENSG00000102878:HSF4:chrl6:+:6720 :9525015:9525141:9520264:953825 rl4:+:21542090:21543339:2153855

1205:67201305:67201125:67201377 4 8:21543490

ENSG00000102038:SMARCAl:chr

X:- ENSG00000156599:ZDHHC5:chrll

ENSG00000219626:FAM228B:chr2:+:2 : 128627016: 128627052: 128626070: :+:57464232:57464345:57463515:5

4390495:24390552:24369956:24392224 128630726 7466030

ENSG00000067191:CACNBl:chrl7:- ENSG00000145819:ARHGAP26:ch ENSG00000155816:FMN2:chrl:+:2

:37341383:37341403:37341117:3734274 r5:+: 142416760: 142416826: 142393 40343468:240343480:240341368:24

8 681:142421380 0351506

ENSG00000073584 : SMARCEl xhr ENSG00000128805:ARHGAP22:ch 17:- rlO:-

ENSG00000132153:DHX30:chr3:+:4785 :38798706:38798811:38793824:388 :49687630:49687807:49667934:497

7452:47857618:47852201:47868836 02047 63507

ENSG00000198563:DDX39B:chr6:

ENSG00000070961:ATP2Bl:chrl2:- ENSGOOOOO 173226 :IQCB 1 : chr3 : -

:89992366:89992520:89985072:8999289 :31506539:31506716:31504460:315 : 121491403: 121491560: 121489421:

3 08098 121500589

ENSG00000062598:ELM02:chr20:

ENSG00000101017:CD40:chr20:+:

ENSG00000186312:CA5BPl:chrX:+:15 :45027335:45027410:45023142:450 44751764:44751858:44751395:4475

711085:15711181:15706981:15715362 35186 5278

ENSG00000139370:SLC15A4:chrl

ENSG00000198216:CACNAlE:chrl:+:l 2:- ENSG00000197558:SSPO:chr7:+:l

81750562:181750659:181745364:18175 : 129294487: 129294598: 129294018: 49523538:149523666:149523366:14

2814 129299319 9524857

ENSG00000163281:GNPDA2:chr4:

ENSG00000129159:KCNCl:chrll:

ENSG00000088367 :EPB41L 1 :chr20 :+: 3 :44724100:44724259:44713154:447 +: 17801002: 17801191: 17794145: 17 4783250:34783286:34782282:34785780 28490 875089

ENSG00000112031 :MTRFlL:chr6:

ENSG00000134283:PPHLNl:chrl2:

ENSG00000078140 :UBE2K:chr4 :+: 397 : 153312319: 153312551:153311230: +:42768757:42768876:42749024:42 39039:39739133:39700010:39776453 153313991 781257

ENSG00000205593:DENND6B:chr

ENSG00000058673 :ZC3H11 A:chrl 22:-

ENSG00000219626:FAM228B:chr2:+:2 :+:203772084:203772144:20376492 :50754994:50755141:50754904:507

4390495:24390552:24358057:24392224 2:203786053 55721

ENSG00000185753:CXorf38:chrX:- ENSG00000146416:AIGl:chr6:+:14 ENSG00000135502:SLC26A10:chr

:40498260:40499572:40496408:4050625 3605246:143605362:143486320:143 12:+:58017618:58017696:58016920

8 654418 :58018648

ENSG00000119242:CCDC92:chrl2:- ENSG00000196792 : STRN3 : chrl 4 : - ENSGOOOOO 104450 : SPAG1 :chr8 :+: : 124429215 : 124429287: 124428911 : 1244 :31388171:31388312:31382863:314 101232506:101232659:101226146:1 56441 04368 01237400 ENSG00000196132:MYTl:chr20:+: ENSG00000144283:PKP4:chr2:+:15

ENSG00000103540:CCP110:chrl6:+:19 62821415:62821513:62796092:6283 9533250:159533379:159530512:159

537040:19537183:19535410:19539188 0214 536940

ENSG00000163126:ANKRD23:chr

ENSG00000133619:KRBAl:chr7:+:149 ENSG00000114735 :HEMKl:chr3:+ 2:-

427517:149427658:149425766:1494287 :50615256:50615306:50615004:506 :97506563:97506649:97506251:975

61 17274 07796

ENSG00000133059:DSTYK:chrl> ENSG00000188529:SRSF10:chrl:- ENSG00000140398:NEILl:chrl5:+:

:205117332:205117467:205116873 :2051 :24298062:24298116:24294213:242 75644451:75644571:75641680:7564 19807 98339 4664

ENSG00000163629:PTPN13:chr4:+ ENSGOOOOO 138777 :PP A2 : chr4 : -

ENSG00000068354:TBClD25:chrX:+:4 :87674161:87674218:87672277:876 : 106359106: 106359193: 106345479:

8417284:48417412:48403411:48417545 79412 106367539

ENSG00000072803 :FBXW11 :chr5 :

ENSG00000163531 :NFASC:chrl :+:

ENSG00000006194 :ZNF263 : chrl 6 :+: 33 204970297:204970414:204957934:2 : 171341346: 171341409: 171337801: 38453:3338570:3336149:3339392 04971723 171433461 ENSG00000076864:RAPlGAP:chrl:- ENSG00000130751 :NPAS 1 :chrl 9 :+ :21930327:21930405:21929406:2193255 :47542664:47542822:47539387:475 ENSG00000101298:SNPH:chr20:+: 8 43701 1277788:1277896:1247404:1281205

ENSG00000125462:Clorf61:chrl:- ENSG00000114439:BBX:chr3 :+: 10 ENSG00000271723:MROH7- : 156383875: 156384090: 156377767: 1563 7508633 : 107508723 : 107497366: 107 TTC4:chrl :+:55174686:55174749:5 99167 510086 5172210:55181195

ENSG00000075711 :DLG1 :chr3 :- ENSG00000164609:SLU7:chr5:- ENSG00000101187:SLC04Al:chr2 : 196795372: 196795408: 196793625: 1967 : 159845602: 159845692: 159842317: 0:+:61287710:61288602:61273905: 96089 159846029 61299096

ENSGOOOOO 197467: COL 13 A1 :chrl

ENSG00000145216:FIPlLl:chr4:+:5430 ENSG00000164828:SUNl:chr7:+:8 0:+:71654307:71654334:71649196:

6748:54306775:54294350:54308819 72141:872238:856310:881582 71654430

ENSG00000178104:PDE4DIP:chrl:

ENSG00000133059:DSTYK:chrl:- ENSG00000154582:ELOC:chr8:- :205156545:205156934:205138960:2051 :74881794:74881908:74868289:748 : 144955215: 144955292: 144946742: 80398 84311 144994590

ENSG00000065600:TMEM206:chrl:- ENSG00000115289:PCGFl:chr2:- ENSG00000185880:TRIM69:chrl5:

:212550903:212551048:212538718:2125 :74732678:74732765:74732546:747 +:45050810:45051052:45048661:45

53236 33858 051837

ENSG00000140326:CDANl:chrl5:

ENSG00000137817:PARP6:chrl5:- ENSG00000135502:SLC26A10:chr :72543185 :72543298:72542433 :7254354 :43026423:43026544:43026245:430 12:+:58017785:58017881:58017696 7 27297 :58018282

ENSG00000272752: STAG3L5P-

ENSG00000017260:ATP2Cl:chr3:+:130 PVRIG2P- ENSGOOOOO 125834 : STK35 : chr20 :+

613433:130613619:130613181:1306492 PILRB:chr7:+:99950832:99950893: :2097311:2098061:2084011:212442

59 99950746:99952765 9

ENSG00000171055:FEZ2:chr2:- ENSGOOOOO 160201 :U2AF 1 : chr21 : -

ENSG00000139567:ACVRLl:chrl2:+:5 :36787927:36788008:36785656:368 :44520562:44520629:44515853:445

2307342:52307554:52307134:52308222 05739 21475

ENSG00000112234:FBXL4:chr6:- ENSG00000137501:SYTL2:chrll:-

ENSG00000168958:MFF:chr2:+:228193 :99328428:99328500:99323603:993 :85425455:85425550:85416071:854

393:228195562:228190143:228197134 47143 29832

ENSG00000166927:MS4A7:chrll: ENSG00000187688:TRPV2:chrl7:+

ENSG00000069424 :KCNAB2:chrl :+:61 +:60160157:60160259:60157069:60 : 16338172: 16338283: 16337012: 163 01890:6101932:6100705:6132814 161259 40102

ENSG00000197444:OGDHL:chrl0:

ENSG00000102921:N4BPl:chrl6:-

ENSG00000105662:CRTCl:chrl9:+:188 :50947706:50947885:50946308:509 :48585296:48585393:48582025:485

85709:18885796:18882356:18886450 50873 87449

ENSG00000162910:MRPL55:chrl:- ENSG00000104529:EEFlD:chr8:-

ENSG00000002016:RAD52:chrl2:- :228296137:228296209:228296019: : 144674816: 144675063 : 144672251 : : 1023596: 1023698: 1023287 : 1025509 228296655 144679517

ENSG00000109536:FRGl:chr4:+:l ENSG00000196961:AP2Al:chrl9:+

ENSG00000011021 :CLCN6 :chrl :+: 1188 90876191:190876306:190873442:19 :50305790:50305856:50305398:503 8514:11888681:11888276:11889252 0878552 06205

ENSG00000115084: SLC35F5 :chr2 :

ENSG00000004399 :PLXND 1 :chr3 :- ENSG00000170919:TPT1- : 129278455: 129278626: 129277418: 1292 : 114475329: 114475427: 114472772: ASl:chrl3:+:45957225:45957370:4 79172 114476730 5954136:45965166 ENSG00000007372 :PAX6 :chrl 1 : - ENSG00000116871 :MAP7D1 xhrl : ENSG00000132670:PTPRA:chr20:+ :31823418:31823460:31823324:3182794 +:36640498:36640609:36639079:36 :2955860:2955887:2903931:296741 9 641799 0

ENSG00000164951:PDPl:chr8:+:9 ENSG00000091129:NRCAM:chr7:-

ENSG00000116698:SMG7:chrl:+: 18351 4930138:94930173:94929307:94934 : 107831697: 107831727: 107830190: 6237:183516387:183514447:183518342 243 107832172

ENSG00000065809:FAM107B:chrl

0:- ENSGOOOOO 152223 :EPG5 xhrl 8: -

ENSG00000254986:DPP3:chrll:+:6625 : 14595320: 14595386: 14572514: 146 :43456200:43456307:43450707:434

0521:66250640:66249941:66252643 13761 58340

ENSG00000126746:ZNF384:chrl2:

ENSG00000015153:YAF2:chrl2:- ENSGOOOOO 196428:TSC22D2:chr3 :

:42592937:42593037:42555567:4260415 :6786332:6786425:6782606:678729 +: 150140835: 150140907: 150129095

6 2 : 150174862

ENSG00000164329:PAPD4:chr5:+: ENSG00000273784:RP11-

ENSG00000162374 :EL AVL4 :chrl :+: 50 78938654:78938733:78937019:7894 78J21.7:chrl3:+:53196123:5319639 663100:50663139:50661458:50666522 0945 9:53174355:53201572 ENSG00000079974:RABL2B:chr22

ENSG00000182979:MTAl:chrl4:+:

ENSG00000084072:PPIE:chrl:+:402281 105912003:105912189:105911848:1 :51207882:51207977:51207552:512

88:40228323:40218724:40229360 05916394 14199

ENSG00000155189:AGPAT5:chr8: ENSG00000204619:PPPlRll:chr6:

ENSG00000112851:ERBIN:chr5:+:6536 +:6605190:6605349:6590171:66125 +:30036055:30036130:30035256:30

4704:65364848:65350779:65370851 71 036366

ENSG00000134874:DZIPl:chrl3:- ENSGOOOOO 178741 : C0X5 Axhrl 5

ENSG00000112357:PEX7:chr6:+: 13719 :96251618:96251678:96246340:962 :75219106:75219228:75212783:752 3335:137193391:137167319:137219279 58256 30255 ENSG00000102081:FMRl:chrX:+:1470 ENSG00000125246:CLYBL:chrl3: ENSGOOOOO 174672 :BRSK2 xhrl 1 :+ 19617:147019680:147019119:14702209 +: 100515244: 100515346: 10051130 : 1466200: 1466232: 1464865 : 146652 4 3:100517071 3

ENSG00000220785:MTMR9LP:chr

ENSG00000144908:ALDHlLl:chr3:- ENSG00000147180:ZNF711:chrX: 1:- : 125849065: 125849136: 125844564: 1258 +:84501935:84502189:84501028:84 :32700304:32700415:32697785:327 54377 502552 00552

ENSG00000240207 :RP 11 - ENSG00000203666:EFCAB2:chrl:

ENSG00000109180:OCIADl:chr4:+:488 379F4.4:chr3:+: 158459818: 1584599 +:245165422:245165534:245133745

33243:48833266:48833158:48834636 33:158458255:158501667 :245222687 ENSG00000188130:MAPK12:chr22 ENSG00000087076:HSD17B14:chr

ENSG00000164117 :FBX08 :chr4 : - 19:- : 175177177: 175177296: 175162369: 1751 :50686120:50686205:50685395:506 :49334924:49335016:49318398:493 80849 86318 37532

ENSG00000166682:TMPRSS5:chrll:- ENSG00000168958:MFF:chr2:+:22 ENSG00000145730:PAM:chr5:+:10 : 113569626: 113569749: 113568140: 1135 8211941:228212100:228205096:228 2309819:102310140:102296933:102 76943 220392 325975

ENSG00000177943:MAMDC4:chr9:+:l ENSG00000164548:TRA2A:chr7:- ENSG00000126653:NSRPl:chrl7:+

39753170:139753584:139752998:13975 :23561972:23562051:23561459:235 :28490084:28490180:28445191:284

3660 71407 99559

ENSG00000136861 :CDK5RAP2 :chr9 :- ENSG00000175267:VWA3A:chrl6: ENSG00000142453:CARMl:chrl9: : 123222849: 123222945: 123220900: 1232 +:22153988:22154086:22153013:22 +: 11032050:11032119: 11031803:11 30137 155567 032290

ENSG00000145349:CAMK2D:chr4:- ENSG00000034053:APBA2:chrl5: ENSG00000139631:CSAD:chrl2:- : 114468799: 114468872: 114458599: 1144 +:29386480:29386516:29385423:29 :53565056:53565225:53564286:535 73186 393801 65665

ENSG00000128159:TUBGCP6:chr

ENSG00000171720:HDAC3:chr5:- 22:- ENSG00000138443:ABI2:chr2:+:20 : 141009250: 141009306: 141008873: 1410 :50658679:50660303:50658444:506 4261507:204261690:204260503:204 16114 60456 267298

ENSG00000278259:MY019:chrl7:

ENSGOOOOO 106733 :NMRK1 :chr9 : -

ENSG00000075234:TTC38:chr22:+:466 :34857691:34857801:34857075:348 :77684657:77684729:77684018:776

65038:46665186:46664488:46668231 58936 84810

ENSG00000245694:CRNDE:chrl6:

ENSG00000048991:R3HDMl:chr2:

ENSG00000130803 :ZNF317 xhrl 9 :+: 92 :54954209:54954239:54953121:549 +: 136374237: 136374327: 136362586 68655:9268751:9268070:9269501 57496 : 136379063 ENSG00000129197:RPAIN:chrl7:+ ENSG00000173210:ABLIM3:chr5:

ENSG00000144283:PKP4:chr2:+: 15938 :5329555:5329619:5329402:533586 +: 148618810: 148618840: 148617166 9949:159390046:159389828:159433782 1 : 148619321 ENSG00000159111:MRPL10:chrl7:- ENSG00000070501:POLB:chr8:+:4 ENSG00000187239 :FNBP 1 : chr9 : - :45906504:45906602:45906036:4590867 2202470:42202537:42196203:42229 : 132686122: 132686305: 132678259: 6 080 132687238

ENSG00000073921 :PICALM:chrl 1 ENSG00000247774:PCED1B-

ASl:chrl2:-

ENSG00000167258:CDK12:chrl7:+:377 :85701292:85701421:85695016:857 :47609947 :47610047 :47604544:476

12538:37712666:37707395:37721012 07868 10166

ENSG00000266173 : STRAD A:chrl

ENSG00000230606:AC159540.1:chr2:- ENSG00000198910:LlCAM:chrX:- 7:- :98088031:98088252:98082014:9808854 : 153128822: 153128834: 153128349: :61800657:61800686:61791468:618 7 153128931 05717

ENSG00000156873:PHKG2:chrl6: ENSG00000053254:FOXN3:chrl4:-

ENSG00000175606 :TMEM70 :chr8 :+:74 +:30767502:30767593:30764878:30 :89656727:89656793:89647150:897 891313:74891406:74888726:74893389 767687 47293 ENSG00000124772:CPNE5:chr6:- ENSG00000068724:TTC7A:chr2:+: ENSG00000070501:POLB:chr8:+:4 : 36759809:36759873:36746734:3676236 47233779:47233863:47222338:4723 2210036:42210086:42206608:42213 6 8469 033

ENSG00000106077 : ABHD 11 :chr7 :- ENSG00000083535:PIBFl:chrl3:+: ENSG00000160226:C21orf2:chr21:- :73152205:73152402:73152065:7315265 73539411:73539542:73505405:7357 :45755640:45755687:45753145:457 7 2959 57531

ENSG00000115977: AAKl:chr2:- ENSG00000137210:TMEM14B:chr ENSG00000105698:USF2:chrl9:+:3 :69723116:69723212:69708093 :6973270 6:+: 10770309: 10770437: 10751467: 5760705:35760906:35760602:35761 0 10829239 349

ENSG00000145014:TMEM44:chr3:

ENSG00000128596:CCDC136:chr7

ENSG00000163517 :HD AC11 :chr3 :+: 13 :+: 128454691 : 128454973 : 12845298 : 194313769: 194313802: 194309368: 538235:13538352:13525064:13545593 3:128457811 194325015

ENSG00000128159 : TUB GCP6 : chr2

ENSG00000204790 : CB WD6 : chr9 : - ENSG00000163539:CLASP2:chr3:- 2:- :69234829:69234952:69218561:6923556 :33636442:33636460:33633988:336 :50658620:50660303:50658444:506

1 44443 60456

ENSG00000138867:GUCDl:chr22:- ENSG00000104613:INTS10:chr8:+: :24939809:24940051:24939068:2494288 ENSG00000007392:LUC7L:chrl6:- 19706672:19706750:19703308:1970 1 :278331:278401:277335:279277 9159 ENSG00000179588:ZFPMl:chrl6: ENSG00000117640:MTFRlL:chrl:

ENSG00000198453:ZNF568:chrl9:+:37 +:88580794:88580928:88555561:88 +:26149486:26149619:26146520:26 413487:37413748:37408550:37416101 593221 150134 ENSG00000110931:CAMKK2:chrl2:- ENSG00000064787:BCASl:chr20:- ENSG00000066468:FGFR2:chrl0:- : 121686408: 121686537: 121683043: 1216 :52573970:52574036:52570234:526 : 123325150: 123325218: 123324093: 87589 01825 123353222

ENSG00000107105:ELAVL2:chr9:- ENSG00000148187:MRRF:chr9:+:l ENSG00000116750:UCHL5:chrl:-

:23693445:23693484:23692882:2370137 25027740:125028059:125027217:12 : 192989436: 192989511 : 192985525:

6 5033142 192990226

ENSG00000214135:AC024560.3:chr3:- ENSG00000115661 :STK16:chr2:+: ENSG00000138802: SEC24B :chr4 :+ : 197349057: 197349201: 197348739: 1973 220111834:220111968:220111598:2 : 110402832: 110402937: 110394342: 50090 20112136 110412482

ENSG00000140612:SECllA:chrl5:

ENSG00000107829:FBXW4:chrl0:- : 103436097: 103436193: 103384567: 1034 ENSG00000183044:ABAT:chrl6:+: :85223162:85223200:85214013:852 54137 8807347:8807722:8806919:8829555 30855

ENSG00000118518:RNF146:chr6:+:127 ENSG00000164124:TMEM144:chr ENSG00000021645:NRXN3:chrl4:

601660:127601749:127601485:1276071 4:+: 159136342: 159136465: 1591339 +:80158515:80158605:80130292:80

94 28:159140461 163972

ENSG00000171103 :TRMT61B :chr 2:- ENSG00000220804 :LINC01881 xhr

ENSG00000163719:MTMR14:chr3:+:97 :29083983:29084174:29075365:290 2:+:243037037:243037178:2430309

39394:9739550:9730766:9743473 92444 52:243056789

ENSG00000066629:EMLl:chrl4:+:1003 ENSG00000141480:ARRB2:chrl7: ENSG00000110075 :PPP6R3 :chrl 1 :

41267:100341324:100331983:10034482 +:4618307:4618338:4614039:46184 +:68377078:68377096:68370960:68

1 94 377371

ENSG00000261611:AC010547.9:ch

ENSG00000121753:ADGRB2:chrl:- rl6:- ENSG00000103550:KNOPl:chrl6:-

:32208438:32208603:32207818:3220979 :71487145:71487253:71483788:714 : 19722693 : 19722762 : 19721908:197

3 90666 25439 ENSG00000166073:GPR176:chrl5:- ENSG00000224078 : SNHG14 xhrl 5 ENSG00000130159:ECSIT:chrl9:-

:40099206:40099459:40094455:4021205 :+:25479204:25479350:25477902:2 : 11618516: 11618544: 11618377: 116

5 5479721 18805

ENSG00000168453:HR:chr8:- ENSG00000162961 :DPY30 : chr2 : -

ENSG00000105953:OGDH:chr7:+:4469 :21980005:21980121:21978741:219 :32108454:32108531:32095021:321 5916:44695961:44687133:44706334 80302 17060 ENSG00000177303 : CASKIN2 : chrl 7 : - ENSG00000123983:ACSL3:chr2:+: ENSG00000128596:CCDC136:chr7 :73500652:73500774:73500561:7350163 223765391:223765498:223725976:2 :+: 128452761 : 128452983 : 12844595 7 23773450 5:128457811

ENSG00000138606 : SHF xhrl 5 : - ENSG00000132716:DCAF8:chrl:- ENSG00000111364:DDX55:chrl2: :45465773:45465914:45460331:4546741 : 160231074: 160231148: 160213824: +: 124103215: 124103384: 124101150

6 160232238 :124103994

ENSG00000249141:RP11-

514012.4:chr6:- ENSG00000136643 :RPS6KC1 xhrl ENSG00000175029:CTBP2:chrl0:-

: 167360169: 167360227: 167356577: 1673 :+:213302869:213303232:21329075 : 126727565: 126727724: 126692061 : 69584 2:213341200 126799558

ENSG00000140873:ADAMTS18:chrl6:

ENSG00000234456:MAGI2- ENSG00000007047:MARK4:chrl 9 :

:77325162:77325375:77323308:7732697 AS3:chr7:+:79099909:79099995:79 +:45801400:45801480:45801212:45 2 088315:79100098 803068

ENSG00000160183:TMPRSS3:chr2

ENSG00000089169:RPH3A:chrl2:+:113 ENSG00000146083:RNF44:chr5:- 1:-

274295:113274307:113266194:1132855 : 175957848: 175958022: 175957744: :43803141:43803307:43802343:438

00 175958463 04078

ENSG00000263072:ZNF213- ENSG00000104299:INTS9:chr8:-

ASl:chrl6:- :28704263 :28704326:28695293 :287 ENSG00000161999:!M!D8:chrl6:-

:3181747:3181922:3179654:3182019 07729 :733166:733234:732874:733321 ENSG00000048140:TSPAN17:chr5:+:17 ENSG00000104863:LIN7B:chrl9:+ ENSGOOOOO 158201 : ABHD3 xhrl 8 :- 6083895:176083925:176083817:176084 :49618516:49618588:49618224:496 : 19263880: 19263926: 19239304: 192 518 21111 82276

ENSG00000276087 :RP 11 - ENSG00000184154:LRTOMT:chrl

ENSG00000090905:TNRC6A:chrl6:+:2 507M3.1:chr2:+:24357988:2435805 1:+:71799385:71799426:71791931: 4804793 :24804970:24803138:24805864 7:24347330:24387067 71800074 ENSG00000204536:CCHCRl:chr6:

ENSG00000124783:SSRl:chr6:-

ENSG00000090554:FLT3LG:chrl9:+:49 :31122272:31122576:31118899:311 :7295320:7295335:7290164:729562 978930:49979058:49977929:49979401 24507 4 ENSG00000144445 :KANSL 1L :chr2 :- ENSG00000072182 : ASIC4 :chr2 :+:2 ENSG00000166986:MARS:chrl2:+: :210962809:210962931:210908828:2109 20397604 :220397661 :220397199:22 57906085:57906136:57905886:5790 68827 0399892 6533

ENSG00000122203 :KIAA1191 :chr5 :- ENSG00000149294:NCAMl:chrll: ENSGOOOOO 118194 :TNNT2 :chrl :- : 175782573 : 175782752: 175777740: 1757 +: 113092017: 113092047: 11308523 :201334318:201334435:201333503: 88604 3:113101917 201334737

ENSG00000156990:RPUSD3:chr3:- ENSG00000169727:GPSl:chrl7:+:8

ENSG00000048707:VPS13D:chrl:+:123 :9880715:9880855:9879891:988186 0010131:80010335:80009400:80011

98287:12398362:12395884:12401839 7 149

ENSG00000271793 :RP11-

ENSG00000132294:EFR3A:chr8:+:1330 321N4.5:chr6:- ENSG00000137106:GRHPR:chr9:+:

13015:133013245:133008744:13301400 :86275049:86275137:86267778:862 37424841:37424972:37422830:3742

5 81854 8480

ENSG00000253710:ALGll:chrl3:+ ENSG00000090020 : SLC9 A1 xhrl : -

ENSG00000147854:UHRF2:chr9:+:6495 :52598141:52599073:52593279:526 :27440316:27440777:27436268:274

584:6497103:6493932:6497197 02454 80473

ENSG00000101665:SMAD7:chrl8:

ENSG00000067221 : STOML 1 xhrl 5 : - ENSG00000072110:ACTNl:chrl4:- :74276999:74277212:74276471:7427765 :46474753 _: 46474807:46448280:464 :69345174:69345240:69343957:693 8 76181 46678

ENSG00000082014:SMARCD3:chr7:- ENSG00000033627:ATP6V0Al:chr ENSG00000130396:AFDN:chr6:+:l : 150942545: 150942757: 150940787: 1509 17:+:40660589:40660607:40659645 68348532:168348624:168347581:16 72199 :40665878 8348972

ENSG00000161642:ZNF385A:chrl2:- ENSG00000206503 :HLA- ENSG00000100109:TFIPll:chr22:- : 54765256:54765426:54764880: 5476775 A:chr6:+:29912276:29912393:2991 :26907084:26907283:26906668:269

6 2174:29912835 08064

ENSG00000111731 :C2CD5:chrl2:- ENSG00000126583:PRKCG:chrl9: ENSGOOOOO 107164 :FUBP3 : chr9 : +: :22672048:22672173 :22666313 :2267635 +:54396241:54396329:54395897:54 133510053:133510125:133507665:1 9 396615 33511385 ENSG00000008128:CDKllA:chrl:

ENSG00000067840 :PDZD4 xhrX:- ENSG00000109762:SNX25:chr4:+: : 153073351:153073594: 153072295: 1530 : 1654026: 1654073: 1653150: 165414 186272598:186272763 : 186267804: 1 73796 6 86274638

ENSG00000031823 :RANBP3 xhrl 9

ENSG00000164758:MED30:chr8:+:118 ENSG00000169738:DCXR:chrl7:-

542961:118543066:118533292:1185521 :5957917:5957984:5933490:597807 :79994289:79994324:79994184:799

21 1 94419

ENSG00000005379:TSPO API xhrl

ENSG00000141542:RAB40B:chrl7:- 7:- ENSG00000010803 :SCMH1 :chrl :-

:80616366:80616438:80616010:8061745 :56385901:56386741:56385302:563 :41618270:41618413:41617356:416

5 87327 25396

ENSG00000175061 :LRRC75A- ENSG00000137449:CPEB2:chr4:+:

ENSG00000088367 :EPB41L 1 :chr20 :+: 3 ASl:chrl7:+: 16342640: 16342707:1 15009961:15010051:15009210:1501 4788794:34788899:34785963:34797409 6342374:16343498 8811

ENSG00000100263 :RHBDD3 :chr2

ENSG00000131773 :KHDRBS3 xhr 2:-

ENSG00000095564:BTAFl:chrl0:+:937 8:+: 136657301: 136657360: 1365943 :29656690:29656857:29656602:296

48910:93749337:93744161:93751875 16:136659235 57188

ENSG00000010244 :ZNF207:chrl7 : ENSG00000123349:PFDN5:chrl2:+

ENSG00000178498:DTX3:chrl2:+:5799 +:30693683:30693776:30692506:30 :53690027:53690059:53689423:536

9972:58000035:57998641:58002859 694790 91828

ENSG00000100280:APlBl:chr22:- ENSG00000116885 :0SCP1 xhrl : -

ENSG00000090565:RABllFIP3:chrl6: :29735742:29735763:29735122:297 :36909604:36909634:36904511:369 +:541133:541268:539000:546823 36644 15858 ENSG00000106772 :PRUNE2 :chr9 : - ENSG00000118007 : STAG1 :chr3 : - ENSG00000128294:TPST2:chr22:- :79239367:79239406:79234303:7924410 : 136287606: 136287703: 136261037: :26940569:26940641:26928711:269 7 136323150 86016

ENSG00000059588:TARBP1 xhrl :- ENSG00000165802:NSMF:chr9:-

ENSG00000168591:TMUB2:chrl7:+:42 :234529107:234529222:234528298: : 140350080: 140350086: 140348895:

265274:42265377:42264477:42266302 234529391 140350862

ENSG00000198208 :RPS6KL 1 xhrl 4:- ENSG00000148840:PPRCl:chrl0:+

ENSG00000274211:SOCS7:chrl7:+:365 :75375803:75375893:75375635:753 : 103902801: 103902855: 103901761: 21190:36521916:36520739:36522169 76245 103906428 ENSG00000056586:RC3H2:chr9:- ENSG00000110074 :FOXRED lxhr ENSG00000140367:UBE2Q2:chrl5 : 125613601: 125613715: 125613508: 1256 11:+: 126144821: 126144916: 126143 :+:76171438:76171529:76161351:7 16230 349:126145688 6175706

ENSG00000139220:PPFIA2:chrl2:- ENSG00000162804:SNEDl:chr2:+: ENSG00000173905:GOLIM4:chr3:- :81676788:81676818:81675211:8167801 242002207:242002321:241992743:2 : 167758573 : 167758657: 167754782: 9 42003003 167759179

ENSG00000136717:BINl:chr2:- ENSG00000124313 :IQSEC2:chrX:- ENSG00000130755:GMFG:chrl9:- : 127809830: 127809938: 127806209: 1278 :53321076:53321106:53285243:533 :39826074:39826194:39825950:398 16586 49614 26613

ENSG00000233184:RP11- ENSG00000119820:YIPF4:chr2:+:3

ENSG00000101150:TPD52L2:chr20:+:6 421L21.3:chrl:+: 101549016: 101549 2523302:32523380:32517417:32526

2507168:62507228:62505169:62514071 130:101546169:101552407 450 ENSG00000125462:Clorf61:chrl:- ENSG00000108433:GOSR2:chrl7:

ENSG00000054523:KIFlB:chrl:+:1033 : 156383847: 156384090: 156377767: +:45009432:45009565:45006950:45

3071:10333089:10332364:10335485 156384445 015964

ENSGOOOOO 134644 :PUM lxhrl:- ENSG00000111711:GOLTlB:chrl2

ENSG00000184792:OSBP2:chr22:+:311 :31452908:31453010:31447649:314 :+:21661316:21661495:21654882:2

37147:31137356:31091540:31266415 54158 1665228

ENSG00000168300:PCMTDl:chr8:

ENSG00000115194:SLC30A3:chr2:- ENSG00000111011:RSRC2:chrl2:-

:27480772:27480926:27480220:2748102 : 122998313 : 122998421 : 122995735 : :52773404:52773806:52758323:528

8 123001773 11489

ENSG00000160050:CCDC28B:chrl ENSG00000088766 :CRLS 1 :chr20 :+

ENSG00000243989:ACYl:chr3:+:52019 :+:32669833:32669980:32669646:3 :6011930:6012016:5996136:601265 222:52019287:52018174:52019376 2670198 7 ENSG00000204301 :NOTCH4 :chr6 :- ENSG00000177200:CHD9:chrl6:+: :32164100:32164198:32163927:3216470 53353724:53353863:53352252:5335 ENSG00000157954:WIPI2:chr7:+:5 1 5437 232748:5232802:5230124:5239206

ENSG00000273167:RP11- ENSG00000131626:PPFIA1 xhrl 1 : ENSG00000069849:ATPlB3:chr3:+

307N16.6:chrl3:+:24860902:24861088:2 +:70179127:70179202:70178200:70 : 141635217: 141635282: 141634862:

4860531:24863136 179575 141644372 ENSG00000160991:ORAI2:chr7:+:1020 ENSG00000143224:PPOX:chrl:+:l ENSG00000111364:DDX55:chrl2: 76671 : 102076780: 102074108: 10207939 61136889:161137024:161136724:16 +: 124102304: 124102419: 124101150 0 1140409 :124103994

ENSG00000184271:POU6Fl:chrl2:

ENSG00000065882:TBClDl:chr4:

ENSG00000119725 :ZNF410:chrl4:+:74 :51600572:51600667:51598151:516 +:38054726:38054846:38051519:38 358729:74358810:74353618:74360499 11425 055819

ENSG00000259024:TVP23C-

ENSG00000173744:AGFGl:chr2:+:228 ENSG00000144134:RABL2A:chr2: CDRT4:chrl7:-

414774:228414822:228401709:2284166 +: 114398929: 114399027: 11439270 : 15457078: 15457143: 15450462: 154

74 7:114399357 58595

ENSG00000139116:KIF21A:chrl2:

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000009950:MLXIPL:chr7:-

1700035:131700057:131698924:131702 :39724043:39724064:39720126:397 :73010968:73011116:73010809:730

877 24547 11194

ENSG00000068903 : SIRT2 xhrl 9:- ENSG00000114867:EIF4Gl:chr3:+: ENSGOOOOO 188674 : C2orf80 : chr2 : -

:39384458:39384507:39380784:3939014 184034500:184034521:184034006:1 :209049674:209049756:209046029:

5 84035108 209051669

ENSG00000187109:NAPlLl:chrl2:

ENSG00000063601 :MTMR1 xhrX:

ENSG00000131584 : ACAP3 xhrl :- :76453917:76454059:76449941:764 +: 149882950: 149883001:149867773 : 1242716: 1242763 : 1239523 : 1243148 78346 : 149887096

ENSG00000124789:NUP153:chr6:- ENSG00000167766:ZNF83:chrl9:-

ENSG00000173947:PIFO:chrl:+:111891 : 17669205: 17669259: 17665616: 176 :53119970:53120094:53118050:531

137:111891268:111889671:111892727 69523 22188

ENSG00000121753:ADGRB2:chrl:- ENSG00000076554:TPD52:chr8:- ENSG00000172824:CES4A:chrl6:+

:32209793:32209958:32208603:3221024 :80962679:80962706:80954903:809 :67040647:67040720:67039296 :670

8 63761 42876

ENSG00000120860:WASHC3:chrl

ENSG00000015592: STMN4 :chr8 : - ENSG00000122545 : SEPT7 :chr7 :+: 2:- :27096742:27096796:27094422:2709748 35870962:35871106:35840880:3587 : 102411497: 102411583: 102406970:

7 2407 102419751

ENSG00000245213:RP11-

ENSG00000137312:FLOTl:chr6:- 10K16.1:chr4:- ENSG00000067225:PKM:chrl5:-

:30709568:30709644:30708575:3070992 : 174087795 : 174087941 : 174087450: :72513508:72513625:72511451:725

3 174089112 23236

ENSG00000009307:CSDE1 xhrl :- ENSG00000105552:BCAT2:chrl9:-

ENSG00000114125 :RNF7:chr3:+: 14146 :115273128:115273269:115269711: :49309773:49309974:49303554:493 1485:141461749:141457351:141462350 115275224 14240

ENSG00000141447:OSBPLlA:chrl

ENSG00000141837:CACNAlA:chrl9:- ENSG00000151491:EPS8:chrl2:- 8:- :13321430:13321466:13320312:1332291 : 15835826: 15835906: 15823857: 159 :21921510:21921622:21914294:219 6 42094 46855

ENSG00000167766:ZNF83:chrl9:- ENSG00000178971:CTCl:chrl7:- ENSG00000102181:CD99L2:chrX:- :53119970:53120068:53118050:5312218 :8132044:8132210:8131947:813245 : 149940277: 149940295: 149938842:

8 9 149944646

ENSG00000243069:ARHGEF26- ENSG00000130559:CAMSAPl:chr

ASl:chr3:- ENSG00000197580:BC02:chrll:+: 9:-

: 153837474: 153837597: 153748168: 1538 112065375:112065478:112064717:1 : 138773478: 138773640: 138758382: 38860 12070421 138798845

ENSG00000182985 :CADM1 xhrl 1 :

ENSG00000121753:ADGRB2:chrl:- ENSG00000103404:USP31:chrl6:- :32222982:32223112:32222416:3222948 : 115080293 : 115080377 : 115049495 : :23093758:23093878:23091492:230

4 115085327 96180

ENSGOOOOO 122678 :POLM:chr7 : - ENSG00000113763 :UNC5A:chr5:+ :44113729:44113832:44113624:4411399 : 176296614: 176296782: 176295965: ENSG00000172785:CBWDl:chr9:- 6 176297370 : 151304: 151427: 146158: 152033

ENSG00000157890:MEGFll:chrl5:- ENSG00000124523:SIRT5:chr6:+:l ENSG00000103034:NDRG4:chrl6:

:66209165:66209294:66208614:6621030 3599263:13599387:13597248:13601 +:58534891:58534981:58528912:58

3 065 537701

ENSG00000064655:EYA2:chr20:+: ENSGOOOOO 122705 :CLTA:chr9 :+: 3

ENSG00000068724 :TTC7 A:chr2 :+:4725 45700823 :45700891 :45644936:4571 6210621:36210657:36209317:36211 1425:47251498:47238574:47256362 7877 599 ENSG00000090615:GOLGA3:chrl2:- ENSG00000196776:CD47:chr3:- ENSGOOOOO 168066 : SF 1 xhrl 1 : - : 133393125: 133393398: 133390005: 1333 : 107769424: 107769449: 107766139: :64540901:64540977:64537880:645 98581 107770785 43969 ENSG00000185917 : SETD4 :chr21 : - ENSG00000143847:PPFIA4:chrl:+: ENSG00000118473 :SGIP1 :chrl :+:6 :37420605:37420694:37418309:3742588 203025911 :203026078:203025636:2 7101626:67101698:67098777:67105 0 03028305 459

ENSG00000138279:ANXA7:chrl0:

ENSG00000158234:FAIM:chr3:+:l

ENSG00000008083:JARID2:chr6:+:155 38329445:138329879:138327779:13 :75155801:75155867:75148172:751

04730:15504823:15501640:15511526 8340248 56276

ENSG00000137965:IFI44:chrl:+:79

ENSG00000158560:DYNClIl:chr7:+:95 128388:79128563:79125168:791294 ENSG00000164828:SUNl:chr7:+:8

457368:95457428:95439818:95499194 49 72141:872238:856310:878434

ENSG00000258555:SPECC1L- ENSG00000176986:SEC24C:chrl0: ENSGOOOOO 106077 : ABHD 11 :chr7 :-

ADORA2A:chr22:+:24829098:24829704 +:75521855:75521924:75520607:75 :73151258:73151550:73151021:731

:24765288:24836550 523247 51891

ENSG00000108039:XPNPEPl:chrl0> ENSG00000186501 :TMEM222:chr ENSG00000163291:PAQR3:chr4:-

: 111674780 : 111674857: 111667573 : 1116 l:+:27657475:27657628:27657295: :79856274:79856330:79851479:798 83159 27658560 60193

ENSG00000131323 :TRAF3:chrl4:+: 103 ENSG00000081791:KIAA0141:chr ENSGOOOOO 186522: SEPT10 :chr2 :- 352525:103352606:103342862:1033695 5 :+: 141316762: 141316922: 1413141 : 110332157: 110332344: 110325553: 91 51:141318085 110371374

ENSG00000079841:RIMSl:chr6:+: ENSG00000173540:GMPPB:chr3:-

ENSG00000101413:RPRDlB:chr20:+:3 72975662:72975752:72968814:7300 :49759663 :49759791 :49759580:497

6668836:36668966:36662500:36685933 1636 60404

ENSG00000167747:C19orf48:chrl9

ENSG00000214548:MEG3:chrl4:+:

ENSG00000119725 :ZNF410:chrl4:+:74 :51302528:51302614:51302215:513 101302381:101302412:101302216:1 388768:74388909:74387808:74390097 05473 01302503 ENSG00000150977 :RILPL2 :chrl2 :- ENSG00000167515:TRAPPC2L:chr ENSG00000147576:ADHFEl:chr8: : 123915054: 123915206: 123907704: 1239 16:+:88925752:88925851:88925197 +:67355032:67355079:67342613:67 20628 :88926300 356601

ENSG00000135407:AVIL:chrl2:- ENSG00000074266:EED:chrll:+:8 ENSG00000138071:ACTR2:chr2:+:

:58197306:58197452:58197174:5820014 5979497:85979603:85975305:85988 65469182:65469197:65467096:6547

2 021 3657

ENSG00000170919:TPT1- ENSG00000143847:PPFIA4:chrl:+: ENSG00000103043:VAC14:chrl6:-

ASl:chrl3:+:45963869:45963955:45954 203030779:203030806:203030160:2 :70820117:70820268:70819772:708

136:45965166 03032955 34699

ENSG00000119185:ITGBlBPl:chr

ENSG00000283189:RPll-949J7.8:chr3:- ENSG00000169946:ZFPM2:chr8:+: 2:-

:49462381:49462486:49462307:4946279 106431371:106431530:106331209:1 :9554306:9554385:9552534:956350

9 06456507 1

ENSG00000186998:EMIDl:chr22:+ ENSG00000079785:DDXl:chr2:+:l

ENSG00000164329:PAPD4:chr5:+:7893 :29650191:29650276:29639478:296 5735268:15735320:15732073:15736

8666:78938733:78937019:78940945 51259 857

ENSG00000169918:OTUD7A:chrl

ENSG00000128739 : SNRPN hrl 5 : 5:-

ENSG00000177106:EPS8L2:chrll:+:72 +:25165619:25165694:25165271:25 :31981561:31981684:31949280:321

2090:722165:721691:722400 207260 62709

ENSG00000163281:GNPDA2:chr4:

ENSG00000170873:MTSSl:chr8:- ENSG00000178467:P4HTM:chr3:+: : 125570953: 125571073: 125570116: 1255 :44719129:44719312:44713154:447 49042293:49043300:49040029:4904 75022 28490 4119

ENSG00000134905:CARS2:chrl3:- ENSG00000177663:IL17RA: chr22 : : 111302983:111303447: 111299586:1113 +: 17586742: 17586844: 17586492: 17 ENSG00000159788:RGS12:chr4:+: 15797 588616 3430284:3430438:3429896:3432133

ENSG00000072803 :FBXW11 :chr5 : ENSG00000138668:HNRNPD:chr4:

ENSG00000161692:DBF4B:chrl7:+:428 : 171384600: 171384702: 171337801: :83277689:83277836:83276554:832

11457:42811531:42800390:42814197 171423893 77948

ENSG00000148634:HERC4:chrl0:- ENSG00000113742:CPEB4:chr5:+: ENSG00000044446:PHKA2:chrX:-

:69700695:69700862:69695992:6971435 173370028:173370052:173337607:1 : 18969221: 18969390: 18966944: 189

1 73371969 70611

ENSG00000044446 :PHKA2 :chrX: - ENSG00000133958:UNC79:chrl4:+

ENSG00000088367 :EPB41L 1 :chr20 :+: 3 : 18917290: 18917344: 18915451:189 : 94100866:94100983:94097254: 941 4797409:34797820:34785963:34800193 19602 03561

ENSG00000131069:ACSS2:chr20:+ ENSG00000162585:FAAP20:chrl:-

ENSG00000167258:CDK12:chrl7:+:377 :33509588:33509669:33470792:335 :2125436:2125572:2125349:212612

07290:37707395:37704083:37712538 11125 6 ENSG00000251022 :THAP9-AS 1 :chr4 :- ENSG00000070501:POLB:chr8:+:4 ENSG00000101247:NDUFAF5 xhr :83816844:83816927:83816000:8381914 2210036:42210086:42202537:42213 20:+: 13773805: 13773873: 13769298 1 033 :13779106

ENSG00000176915:ANKLE2:chrl2:- ENSG00000126858:RHOTl:chrl7: ENSG00000185596:WASH3P:chrl : 133318394: 133318477: 133318071: 1333 +:30548067:30548205:30538257:30 5 :+: 102512025 : 102512252: 1025064 19739 551634 26:102512798

ENSG00000165912:PACSIN3:chrl

ENSG00000064490:RFXANK:chrl 1:-

ENSG00000198909:MAP3K3:chrl7:+:6 9:+: 19307994: 19308060: 19307855: : 47204224:47204360:47204110 :472

1712068:61712161:61710162:61723393 19308329 04554

ENSG00000107679:PLEKHAl:chr ENSG00000134982:APC:chr5:+:ll

ENSG00000046651 :OFD 1 :chrX:+: 1375 10:+: 124187791: 124187936: 124186 2170647:112170862:112164669:112 8207:13758332:13757151:13762533 547:124189139 173249 ENSG00000026297 :RNASET2 :chr6 :- ENSG00000116254:CHD5:chrl:- ENSG00000112425 :EPM2A:chr6:- : 167368982: 167369115: 167366036: 1673 :6166454:6166569:6166347:616667 : 146042036: 146042291 : 146007432: 69584 5 146056333

ENSG00000283486:RP11-

ENSG00000137312:FLOTl:chr6:- ENSG00000138750 :NUP54 :chr4 :- 392E22.9:chr9:- :30709390:30709481:30709110:3070956 :77068631 :77068793 :77065626:770 :38541452:38541559:38540846:385 8 69460 42308

ENSG00000228327:RP11- ENSGOOOOO 184465 : WDR27 : chr6 : - ENSG00000136709 :WDR33 :chr2 :-

206L10.2:chrl:- : 170063658: 170063745 : 170062520: : 128471156: 128471595: 128467430:

:703927:703993:701767:704876 170064261 128474728

ENSG00000166682:TMPRSS5:chrl

ENSG00000106772 :PRUNE2 :chr9 : - 1:- ENSG00000100505:TRIM9:chrl4:- :79234255:79234303:79229516:7923936 : 113565199: 113565362: 113563971: :51464767:51464906:51448821:514 7 113566121 75797

ENSG00000197580:BC02:chrll:+:1120 ENSG00000169919:GUSB:chr7:- ENSG00000116299:KIAA1324:chr 70421 : 112070550: 112065478: 11207133 :65444713 :65444898:65444528:654 1 :+: 109740600: 109740697: 1097402 5 45210 76:109741194

ENSG00000145349:CAMK2D:chr4 ENSG00000215041 :NEURL4 :chrl7

ENSG00000162341:TPCN2:chrll:+:688 : 114426131 : 114426191 : 114424133 : :7221813:7221993:7221675:722236

47301:68847351:68846488:68848867 114430793 8

ENSG00000154319:FAM167A:chr8

ENSG00000100505:TRIM9:chrl4:- ENSG00000172995 : ARPP21 :chr3 :+ :51450097:51450139:51448821:5145267 :35758789:35758849:35732497:357 : 11301539: 11302317: 11282145: 113 3 63096 24134

ENSG00000182796:TMEM198B:ch ENSG00000214548:MEG3:chrl4:+:

ENSG00000164535 :D AGLB : chr7 : - rl2:+:56226654:56226798:5622486 101302378:101302412:101297871:1 :6474392:6474651:6472590:6475992 7:56227230 01302503 ENSG00000143409:MINDYl:chrl:- ENSG00000100503:NIN:chrl4:- ENSG00000035928:RFCl:chr4:- : 150974640: 150974799: 150974258: 1509 :51233024:51233114:51230682:512 :39308211:39308321:39306548:393 78787 33497 13064

ENSGOOOOO 131018 : SYNE 1 : chr6 : - ENSG00000078369:GNBl:chrl:-

ENSG00000084693:AGBL5:chr2:+:272 : 152466621 : 152466690 : 152464900 : : 1771067: 1771121: 1770677: 182180

92440:27292574:27291612:27292959 152469179 2

ENSG00000088448:ANKRD10:chr

ENSG00000148187:MRRF:chr9:+:1250 ENSG00000160336:ZNF761:chrl9: 13:- 48317: 125048445 : 125047566: 12505402 +:53949479:53949590:53935281:53 : 111552876: 111553041: 111545610:

7 950448 111558379

ENSG00000122126:OCRL:chrX:+:1287 ENSG00000150471:ADGRL3:chr4:

18320:128718344:128710529:12872097 +:62933883:62933935:62910267:62 ENSG00000139197:PEX5:chrl2:+:

8 935826 7354836:7354947:7354437:7356027

ENSG00000228109 :MELTF- ENSG00000120709:FAM53C:chr5: ENSG00000221829:FANCG:chr9:- ASl:chr3:+: 196730967: 196731230: 1967 +: 137676872: 137677102: 13767399 :35076967:35077098:35076580:350 30841:196731364 6:137677497 77260

ENSG00000102606:ARHGEF7:chrl3:+: ENSG00000122367:LDB3:chrl0:+: ENSG00000183077:AFMID:chrl7:

111944464:111944641:111940790:1119 88441192:88441560:88439914:8844 +:76201683:76201834:76198832:76

53094 5434 202026

ENSG00000270580:PKD1P6-

ENSG00000075151 :EIF4G3 :chrl :- ENSG00000163596:ICAlL:chr2:- NPIPPl:chrl6:-

:21308880:21308901:21307720:2132920 :203661612:203661687:203650730: : 15199405: 15199675: 15198615: 151

5 203676468 99971

ENSG00000240771 : ARHGEF25 :ch ENSG00000173210:ABLIM3:chr5:

ENSG00000102898:NUTF2:chrl6:+:678 rl2:+:58009019:58009097:5800880 +: 148617010: 148617166: 148612863

81180:67881359:67880888:67899004 0:58009294 : 148619321 ENSG00000145088:EAF2:chr3:+:l ENSG00000155366:RHOC:chrl:-

ENSGOOOOOH5459:ELMOD3:chr2:+:85 21555491:121555641:121554238:12 : 113247721: 113247823 : 113246428: 614220:85614348:85604597:85616873 1563299 113249699 ENSG00000147408 :CSGALNACT 1 xhr 8:- ENSG00000087995:METTL2A:chr ENSG00000130803:ZNF317:chrl9:

: 19459281: 19459376: 19363641: 1961469 17:+:60512592:60512653:60505198 +:9268509:9268751:9268070:92695 6 :60522197 01

ENSG00000128159 :TUB GCP6 :chr22 : - ENSG00000163644:PPMlK:chr4:- ENSG00000172350:ABCG4:chrll: :50659703:50660303:50658444:5066045 :89189892:89190058:89186287:891 +: 119030936: 119031095 : 119029639 6 98294 :119031247

ENSG00000223745: CCDC18- ENSG00000276550:HERC2P2:chrl ASlxhrl:- 5:- ENSG00000140105:WARS:chrl4:-

:93770944:93771027:93730329:9379019 :23338852:23339028:23335658:233 : 100840472: 100840602: 100835595:

1 56105 100841619

ENSG00000147130 :ZMYM3 : chrX: - ENSG00000028137:TNFRSFlB:chr ENSG00000276087:RP11- :70471027 :70471100 :70470576 :7047140 1:+: 12248852: 12248952: 12227226: 507M3.1:chr2:+:24362239:2436232 7 12251013 0:24358057:24369617

ENSG00000198208 :RPS6KL 1 xhrl 4:- ENSGOOOOO 164638: SLC29A4 :chr7 :

ENSG00000071564:TCF3:chrl9:- :75375803:75376851:75375635:753 +:5327436:5327616:5322713:53303 : 1632330: 1632404: 1627425: 1646353 77950 62

ENSG00000198925:ATG9A:chr2:- ENSGOOOOO 176840:MIR7-

ENSG00000131626:PPFIAl:chrll:+:70 :220093145 :220093207 :220092775 : 3HG:chrl9:+:4769295:4769363:476 212046:70212073:70211541:70218320 220094256 9181:4769641 ENSG00000107863:ARHGAP21:chrl0:- ENSG00000143537:ADAM15:chrl: ENSG00000138613:APHlB:chrl5: :24911661:24911691:24910298:2491892 +: 155034379: 155034593: 15503245 +:63579622:63579745:63578827:63

4 0:155034720 594543

ENSG00000139620 :KANSL2 :chr 12 : - ENSG00000044090 : CUL7 : chr6 : - ENSGOOOOO 117625 :RC0R3 xhrl :+: :49056342:49056437:49054402:4906147 :43015684:43015727:43014845:430 211486061 :211486303 :211462738:2

5 15885 11486765

ENSG00000205336:ADGRGl:chrl ENSG00000272333 :KMT2B xhrl 9 :

ENSG00000174628:IQCK:chrl6:+:1977 6:+:57675502:57675620:57662714: +:36210370:36210443:36209283:36

5169:19775434:19745149:19800159 57684164 210685

ENSG00000141837:CACNAlA:chr

ENSG00000204248 :COL 11 A2 :chr6 : - ENSG00000167772:ANGPTL4:chr 19:- :33153477:33153555:33152831:3315440 19:+:8434102:8434216:8431203:84 : 13321430: 13321466: 13320312: 133 3 35939 23197

ENSG00000074211 :PPP2R2C:chr4:

ENSG00000157445:CACNA2D3:chr3:+ ENSG00000143630:HCN3 xhrl :+: 1

:54596826:54596958:54537681:5460382 :6536997:6537104:6382821:656528 55255514:155255755:155252631:15

1 6 5256963

ENSG00000065600:TMEM206:chr

1:- ENSGOOOOO 187672 :ERC2 :chr3 :-

ENSG00000106052:TAXlBPl:chr7:+:2 :212548534:212548642:212538718: :55717821:55717887:55545304:557

7856508:27856657:27839709:27867356 212553236 33405

ENSG00000132950 :ZMYM5 xhrl 3 :

ENSG00000006740:ARHGAP44:chrl7: ENSG00000171735:CAMTAl:chrl: +: 12877405: 12877627: 12862214: 128833 :20436538:20436606:20426330:204 +:7809830:7809851:7807841:78112 74 37589 58

ENSG00000106665:CLIP2:chr7:+:7

ENSG00000020129:NCDN:chrl:+:3602 ENSG00000197530:MIB2:chrl:+:l 3787261:73787366:73778645:73790

3756:36024085:36023484:36024707 560370:1560565:1560281:1560665 216

ENSG00000133392:MYHll:chrl6:

ENSG00000054965:FAM168A:chrll:- ENSG0000010071 EZFYVE21 xhrl :73136066:73136093:73122581:7314173 : 15802659: 15802698: 15797980: 158 4:+: 104196129: 104196183: 1041955 4 08765 19:104198956

ENSG00000143537:ADAM15:chrl: ENSG00000147996:CBWD5:chr9:-

ENSGOOOOO 156931 :VPS8:chr3 :+: 18456 +: 155034379: 155034593: 15503396 :70471000:70471140:70467530:704 1027:184561033:184557540:184566858 5:155034720 72571

ENSG00000164896:FASTK:chr7:- ENSG00000138769:CDKL2:chr4:-

ENSG00000107771:CCSER2:chrl0:+:86 : 150774187: 150774323: 150773919: :76522118:76522420:76521524:765 267049:86267089:86259715:86273204 150774396 23260 ENSG00000187164:SHTNl:chrl0:- ENSG00000161677:JOSD2:chrl9:- ENSG00000169062:UPF3A:chrl3:+ : 118661275 : 118661468: 118646077: 1186 :51010830:51010956:51009829:510 : 115051733: 115051875: 115047602: 71300 13542 115051993 ENSG00000079819:EPB41L2 :chr6 :

ENSG00000108387:SEPT4:chrl7:- ENSG00000138434:SSFA2:chr2:+:

:56604292:56604339:56603674:5660932 182785323:182785389:182784173:1 : 131190702: 131191266: 131186774:

1 82786674 131206235

ENSG00000173599:PC:chrll:- ENSG00000141376:BCAS3:chrl7: ENSG00000147576:ADHFEl:chr8:

:66721719:66721907:66719939:6672533 +:59104226:59104271:59093262:59 +:67355032:67355079:67344810:67

9 112026 356601

ENSG00000121067:SPOP:chrl7:- ENSG00000204576:PRR3:chr6:+:3 ENSG00000065357:DGKA:chrl2:+

:47745388:47745440:47700238:4775529 0529104:30529285:30525227:30529 :56333865 :56333952:56333313 :563

4 610 34097

ENSGOOOOO 127249 : ATP 13 A4 : chr3 :

ENSG00000031003 :FAM13B :chr5 :- ENSGOOOOO 130023 :ERMARD :chr6 : 137353990: 137354203: 137347634: 1373 : 193156263: 193156373: 193153533: :+:170166733 : 170166763 : 17016262 56719 193156811 7:170168198

ENSG00000169255:B3GALNTl:chr3> ENSG00000186352:ANKRD37:chr ENSG00000143537:ADAM15:chrl:

: 160807731 : 160807850: 160804576: 1608 4:+: 186320100: 186320182: 1863184 +: 155033893: 155033965: 155033308 18926 56:186320723 : 155034720

ENSG00000143847 :PPFIA4 :chrl :+:203 ENSG00000204152 :TIMM23B :chrl ENSG00000008710:PKDl:chrl6:- 018803:203018895:203018108:2030208 0:+:51381761:51381846:51381532: :2163041:2163060:2162964:216316 96 51387652 1

ENSG00000249249:AC010226.4:chr5:+: ENSG00000132821 : VSTM2L :chr20 ENSG00000142949:PTPRF:chrl:+:

114938742:114938853:114938157:1149 :+:36561940:36561991:36560206:3 44041580:44041598:44035449:4404

55764 6572382 4480

ENSG00000254870:ATP6V1G2-

DDX39B:chr6:- ENSG00000122490:PQLCl:chrl8:-

ENSG00000135740:SLC9A5:chrl6:+:67 :31506923:31507051:31504460:315 :77690227:77690311 :77664183 :776

288923:67289087:67286747:67299990 08098 93968

ENSG00000155329:ZCCHC10:chr5

ENSG00000205763:RP9P:chr7:-

ENSG00000114956:DGUOK:chr2:+:741 :32969689:32969720:32961042:329 : 132335823: 132335893: 132334542:

84251:74184367:74154179:74185272 82481 132342450

ENSG00000109072:VTN:chrl7:- ENSG00000163013:FBX041:chr2:- ENSG00000139546:TARBP2:chrl2

:26695892:26696049:26695694:2669630 :73493020:73493094:73492768:734 :+:53898918:53899046:53898599:5

9 93584 3899432

ENSG00000099910 :KLHL22 :chr22 :

ENSG00000185596:WASH3P:chrl5:+:l ENSG00000233184:RP11-

02513422:102513555:102513250:10251 421L21.3:chrl:+: 101549016: 101549 :20819144:20819863:20812287:208

4107 130:101543064:101552407 50046

ENSG00000077254:USP33:chrl:- ENSG00000105053:VRK3:chrl9:- ENSG00000185513:L3MBTLl:chr2

:78180298:78180468:78178966:7818355 :50500760:50500827:50498176:505 0:+:42159437:42159529:42159059:

1 04046 42161412

ENSG00000010165:METTL13:chrl:+:l ENSG00000122034:GTF3A:chrl3: ENSG00000178209:PLEC:chr8:-

71751127:171751260:171750935:17175 +:28006867:28006941:28004758:28 : 145011916: 145011952: 145011410:

2879 008275 145012318

ENSG00000106070:GRB10:chr7:- ENSG00000125510:OPRLl:chr20:+

ENSG00000168904:LRRC28:chrl5:+:99 :50663133:50663227:50660795:506 :62724040:62724306:62711705:627

903310:99903470:99901716:99926234 72986 29154

ENSGOOOOO 157800: SLC37 A3 :chr7 :

ENSG00000160746:AN010:chr3:-

ENSG00000163755 :HPS3 :chr3 :+: 14888 :43641875:43642073:43640158:436 : 140045668: 140045770: 140037149: 4820: 148885027: 148881736:148885679 47205 140048425

ENSG00000159658:EFCAB14:chrl

ENSG00000154380 :ENAH : chrl : - ENSG00000129484:PARP2:chrl4:+

:225704897:225705692:225702602:2257 :20825554:20825679:20825308:208 :47154024:47154216:47152542:471

06899 25796 55258

ENSG00000163539:CLASP2:chr3:- ENSG00000114520:SNX4:chr3:-

ENSG00000239900:ADSL:chr22:+:4076 :33638202:33638226:33636460:336 : 125208251:125208307: 125199163:

0883:40761060:40760369:40762439 44443 125216184

ENSG00000113504:SLC12A7:chr5:

ENSG00000137501:SYTL2:chrll:- ENSG00000066056:TIEl:chrl:+:43

:85422155:85422275:85420543:8542983 773466:43773595:43773243:437746 : 1056696: 1056711:1053597: 105758

2 56 5

ENSG00000107518:ATRNLl:chrl0:+:l ENSG00000168958:MFF:chr2:+:22

17001359:117001514:116975638:11702 8195341:228195562:228190143:228 ENSG00000056998:GYG2:chrX:+:

4669 197134 2795240:2795348:2779763:2799092 ENSG00000103184:SEC14L5:chrl

ENSG00000196557:CACNAlH:chrl6:+ 6:+:5046855:5047045:5046461:505 ENSG00000150995:ITPRl:chr3:+:4

: 1262510: 1262528: 1262138: 1263779 0655 768809:4768857:4753552:4774771

ENSG00000184014:DENND5A:chr ENSG00000178149:DALRD3:chr3:

ENSG00000077782:FGFRl:chr8:- 11

:38287199:38287466:38285953:3831487 :9229107:9229179:9228329:928650 :49054044:49054106:49053944:490

3 7 54206

ENSG00000164061:BSN:chr3:+:49 ENSG00000121957:GPSM2:chrl:+:

ENSG00000158560:DYNClIl:chr7:+:95 697918:49699995:49695629:497018 109427896:109428200:109419850:1

442507:95442649:95439818:95499194 55 09439485

ENSG00000175416:CLTB:chr5:- ENSG00000108231:LGIl:chrl0:+:9

ENSG00000177697:CD151:chrll:+:834 : 175823479: 175823533: 175819946: 5537302:95537374:95518588:95549

529:834803:833026:836062 175824607 855

ENSG00000124831 :LRRFIP1 :chr2: ENSG00000166839:ANKDDlA:chr

ENSG00000058453 :CROCC:chrl :+: 172 +:238647874:238647952:23863657 15:+:65243168:65243448:65242193 97959: 17298142: 17297262:17298854 8:238657006 :65249441

ENSG00000100592:DAAMl:chrl4: ENSG00000163872:YEATS2:chr3:

ENSG00000168297:PXK:chr3:+:583551 +:59805102:59805132:59798638:59 +: 183490092: 183490351:183480067

57:58355205:58318817:58368240 806791 :183491420

ENSG00000176261:ZBTB80S:chrl

ENSG00000080822:CLDNDl:chr3:- ENSG00000125447:GGA3:chrl7:-

:98240496:98240562:98240281:9824169 :73239143:73239339:73238992:732 :33100302:33100393:33087549:331

2 39527 16033

ENSG00000274602:PI4KAP1 :chr22

ENSG00000198910:LlCAM:chrX:- ENSG00000105662:CRTCl:chrl9:+ : 153138682: 153138697: 153138152: 1531 :20387161:20387279:20386675:203 : 18882251:18882356: 18871038: 188 41215 88299 86450

ENSG00000173391:OLRl:chrl2:- ENSG00000186567 :CEACAM19 :ch

ENSG00000181666:HKRl:chrl9:+:3781 : 10313384: 10313524: 10313061: 103 rl9:+:45182124:45182208:4517711

3086:37813134:37809088:37814434 19310 7:45183559

ENSG00000107147:KCNTl:chr9:+:138 ENSG00000141452:C18orf8:chrl8: ENSG00000097046 :CDC7 :chrl :+: 9

662143:138662293:138660783:1386627 +:21086933:21087018:21084411:21 1979504:91979600:91978864:91980

02 087948 375

ENSG00000146918:NCAPG2:chr7:- ENSG00000115255 :REEP6:chrl9:+ ENSG00000171163 :ZNF692:chrl :- : 158454885: 158455059: 158451100: 1584 : 1496589: 1496670: 1496452: 149717 :249150571:249150621:249150145: 56875 2 249150712

ENSG00000155313:USP25:chr21:+ ENSG00000157216:SSBP3:chrl:-

ENSG00000158560:DYNClIl:chr7:+:95 : 17196357: 17196485: 17191165: 171 :54723741:54723822:54722859:547

457368:95457428:95442649:95499194 97284 47110

ENSG00000116918:TSNAX:chrl:+ ENSG00000132405:TBClD14:chr4:

ENSG00000170579:DLGAPl:chrl8:- :231699210:231699375 :231697001 : +:7011603 :7011675 :7002978:70123 :3656083:3656113:3582246:3729134 231700273 79

ENSG00000102078:SLC25A14:chr ENSG00000115977: AAKl:chr2:-

ENSG00000137965:IFI44:chrl:+:79126 X:+: 129474080: 129474318: 129473 :69709842:69709944:69708093 :697

238:79126376:79125168:79128388 950:129479155 23116

ENSG00000054356:PTPRN:chr2:- ENSG00000008300:CELSR3:chr3:- ENSG00000175198:PCCA:chrl3:+:

:220162606:220162825:220162155:2201 :48689869:48689986:48689481 :486 101167680:101167821:101101559:1

63768 90434 01179928

ENSG00000166886:NAB2:chrl2:+: ENSG00000145390:USP53:chr4:+:l

ENSG00000110514:MADD:chrll:+:473 57487189:57487381:57486978:5748 20212319:120212416:120194863:12 30530:47330593:47330250:47331057 8394 0213492 ENSG00000144935 :TRPC1 :chr3 :+: 1424 ENSG00000126461:SCAFl:chrl9:+ ENSG00000204463:BAG6:chr6:- 55220: 142455375 : 142443573 : 14246709 :50148277:50148391:50145499:501 :31612083:31612191:31611971:316 9 49364 12301

ENSG00000163072:NOSTRIN:chr2:+:l ENSG00000151657:KIN:chrl0:- ENSG00000088179:PTPN4:chr2:+: 69668076: 169668162: 169659183 :16968 :7817713:7817762:7811308:782080 120639361:120639406:120635118:1 1143 0 20639672

ENSG00000178026:LRRC75B:chr2

ENSG00000228315:GUSBPll:chr22:- 2:- ENSGOOOOO 150672 :DLG2:chrl 1 : -

:24037359:24037704:24026054:2404761 :24988183:24988390:24985917:249 :83191414:83191456:83183820:831

5 88829 94295

ENSG00000129187 :DCTD :chr4 :- ENSG00000112715 :VEGFA:chr6:+ ENSGOOOOO 144406 :UNC80 :chr2 :+: : 183837571: 183837692: 183836728: 1838 :43748468:43748540:43746655:437 210794594:210794695:210791710:2 38463 52277 10795691

ENSG00000151640:DPYSL4:chrl0:

ENSG00000147852:VLDLR:chr9:+:265 ENSG00000188157:AGRN:chrl:+: +: 134005786: 134006024: 134004339

1414:2651498:2650516:2651873 987372:987396:987195:989132 :134006161 ENSG00000141425:RPRDlA:chrl8:- ENSG00000163743:RCHYl:chr4:- ENSG00000177453:NIMlK:chr5:+:

:33613670:33613800:33611060:3364721 :76416792:76416847:76415911:764 43245183:43246169:43192513:4327

6 16933 7158

ENSG00000025708:TYMP:chr22:- ENSG00000136643 :RPS6KC1 :chrl :

ENSG00000119139 :TJP2 :chr9 :+:718642 :50966940:50967039:50966146:509 +:213246211:213246328:213244383 90:71864401:71863140:71867730 68332 :213251037

ENSG00000132466:ANKRD17:chr

ENSG00000133872 : S ARAF :chr8 : - 4:- ENSG00000137944 :KYAT3 :chrl :- :29931392:29931567:29927575:2994036 :74005247:74006000:74000982:740 :89453934:89454034:89435150:894 2 07457 58267

ENSG00000075043 :KCNQ2 :chr20 :- ENSG00000089351:GRAMDlA:ch ENSG00000117069: ST6GALNAC5 :62078099:62078190:62071061:6210352 rl9:+:35513803:35513815:3551294 :chrl:+:77509888:77510298:773344 0 2:35514139 27:77515942

ENSG00000157045 :NTAN1 :chrl6: - ENSG00000127838:PNKD:chr2:+:2 ENSG00000126581:BECNl:chrl7:- : 15141934: 15141956: 15141777: 1514974 19204505:219204621:219136272:21 :40965965:40966026:40962946:409 7 9209530 66541

ENSG00000126106:TMEM53:chrl:- ENSG00000151779:NBAS:chr2:- ENSG00000142949:PTPRF:chrl:+: :45125845:45125967:45111136:4514000 :15319111: 15319240: 15307447:153 44067741:44067768:44064584:4406 2 26865 9086

ENSG00000242759:LINC00882:chr3:- ENSG00000178053:MLFl:chr3:+:l ENSG00000076043 :REX02 :chrl 1 : : 106848734: 106848839: 106830993 : 1069 58306648:158306713:158289136:15 +: 114318547: 114318601: 114311461 59289 8310222 :114320567

ENSG00000196504 RRPF40 A:chr2 :

ENSG00000079841:RIMSl:chr6:+:

ENSG00000134780:DAGLA:chrll:+:61 : 153571063: 153571143: 153551136: 72975662:72975752:72970470:7300

488150:61488362:61487722:61490330 153572508 1636

ENSG00000005379:TSPOAP1 :chrl

ENSG00000005436: GCFC2 :chr2 : - 7:-

ENSG00000175161:CADM2:chr3:+:860 :75907318:75907440:75900646:759 :56402894:56403074:56402363:564 28313:86028433:86010797:86114754 14952 03653 ENSG00000161010 :MRNIP :chr5 : - ENSG00000065978:YBXl:chrl:+:4 ENSGOOOOOO 16864 :GLT8D 1 :chr3 : - : 179274977: 179275066: 179269064: 1792 3161869:43161959:43159194:43162 :52738739:52738968:52734512:527 78242 312 39718

ENSG00000074181 :N0TCH3 :chrl 9

ENSG00000006071 : ABCC8:chrl 1 :-

ENSG00000172366:MCRIP2:chrl6:+:69 : 17416718: 17416822: 17415946: 174 : 15295105: 15295261: 15292612: 152

6471:696608:692249:697416 17156 95716

ENSG00000166169:POLL:chrl0:- ENSG00000100376:FAM118A:chr2

ENSG00000136059:VILL:chr3:+:38044 : 103343264: 103343438: 103342648: 2:+:45723722:45723944:45719308:

658:38044804:38043351:38045745 103347002 45728305

ENSG00000102385:DRP2:chrX:+:l ENSG00000161533:ACOXl:chrl7:-

ENSG00000060237:WNKl:chrl2:+:101 00509847:100509913:100509550:10 :73956295:73956456:73953647:739

0726:1010798:1009836:1013618 0511106 69705

ENSG00000118160:SLC8A2:chrl9:- ENSG00000258653 :RP5- ENSG00000152894:PTPRK:chr6:-

:47944425:47944443:47941230:4794459 1021I20.4:chrl4:+:74389195:74389 : 128316393 : 128316411 : 128313854:

3 400:74388909:74390097 128316606

ENSG00000182109:RP11-

69E11.4:chrl:- ENSG00000035928:RFCl:chr4:- ENSGOOOOO 196405 :EVL :chrl4 :+: 1

:39990507:39990729:39988177:3999472 :39328182:39328260:39322289:393 00605670: 100605706: 100605234: 10

6 29143 0607516

ENSG00000235194:PPPlR3E:chrl ENSG00000079819:EPB41L2 :chr6 :

ENSG00000157538:DSCR3:chr21:- 4:-

:38605662:38605743:38604752:3863953 :23769315:23769348:23768750:237 : 131201593: 131201629: 131199390:

8 69966 131201740

ENSG00000076706 :MCAM:chrl 1 : - ENSG00000151150:ANK3:chrl0:- ENSG00000186088:GSAP:chr7:- : 119181058: 119181176: 119180625: 1191 :61959886:61960021:61958295:619 :76959555:76959684:76955590:769 81465 62759 78667

ENSG00000022567:SLC45A4:chr8:

ENSG00000145362:ANK2:chr4:+:l

ENSG00000224078:SNHG14:chrl5:+:2 : 142231675: 142231864: 142229928: 14293688: 114293781: 114290961 : 11

5246504:25246860:25245521:25264173 142264087 4294245

ENSG00000030110:BAKl:chr6:- ENSG00000185024:BRFl:chrl4:- ENSG00000137842:TMEM62:chrl

:33542282:33542302:33541991:3354307 : 105707601 : 105707751 : 105695250: 5:+:43426454:43426566:43426180:

4 105718843 43427709

ENSG00000136717:BINl:chr2:- ENSG00000170946:DNAJC24:chrl

ENSG00000078018:MAP2:chr2:+:21056 : 127810997: 127811021: 127808819: l:+:31436357:31436496:31392406:

1640:210561775:210545551:210565000 127811480 31447833 ENSG00000139220:PPFIA2:chrl2:- ENSG00000113269:RNF130:chr5:- ENSGOOOOO 100207 :TCF20 : chr22 : - :81678019:81678082:81675211:8168861 : 179390470: 179390564: 179382669: :42564614:42564709:42557364:425 3 179393805 65852

ENSGOOOOO 113649 : TCERG1 : chr5 : ENSG00000135127:BICDLl:chrl2:

ENSG00000155313:USP25:chr21:+:171 +: 145889629: 145889723 : 14588880 +: 120499513: 120499630: 120436540

50222:17150346:17138460:17163820 8:145890003 : 120509425

ENSG00000134222:PSRCl:chrl:- ENSG00000095794:CREM:chrl0:+:

ENSG00000105605 :CACNG7 :chrl 9 :+: 5 : 109825301: 109825358: 109824682: 35490378:35490414:35437419:3549 4444723:54444869:54418759:54445289 109825684 5822 ENSG00000274810:NPHP3- ENSG00000204536:CCHCRl:chr6: ACADll:chr3:- ENSG00000103319:EEF2K:chrl6:+

: 132339975: 132340136: 132338389:1323 :31116181:31116288:31113585:311 :22268963 :22269091 :22268706:222 45534 16394 69814

ENSG00000169064:ZBBX:chr3:- ENSG00000052126:PLEKHA5:chr ENSG00000204469:PRRC2A:chr6: : 167016092: 167016246: 167000283: 1670 12:+: 19443610: 19443730: 19440490 +:31603358:31603526:31603242:31 23430 : 19444577 603743

ENSG00000080822:CLDNDl:chr3:- ENSG00000143774:GUKl:chrl:+:2 ENSG00000011638:TMEM159:chr

:98240496:98240540:98240281:9824169 28329326:228329530:228328064:22 16:+:21185330:21185469:21181926

2 8333211 :21190795

ENSG00000105223:PLD3:chrl9:+: ENSG00000172508:CARNSl:chrll

ENSG00000196204 :RNF216P1 :chr7 :+: 5 40871459:40871492:40854675:4087 :+:67185901:67185991:67183234:6 035105:5035213:5028808:5036240 1624 7186226

ENSG00000126561:STAT5A:chrl7 ENSG00000141469:SLC14Al:chrl

ENSG00000126522:ASL:chr7:+:655480 :+:40443989:40444079:40442040:4 8:+:43310264:43310436:43304978:

63:65548161:65547438:65551571 0447636 43310979

ENSG00000077522:ACTN2:chrl:+: ENSG00000143507:DUSP10:chrl:-

ENSG00000162341:TPCN2:chrll:+:688 236898934:236899020:236894614:2 :221912275:221913129:221879808: 31362:68831435:68830458:68837897 36900421 221915322 ENSG00000111731 :C2CD5:chrl2:- ENSG00000182667:NTM:chrll:+:l ENSG00000070010 :UFD 1L :chr22: - :22611417:22611519:22610095:2262264 32200046:132200079:132184597:13 :19463018:19463125:19459331:194 2 2204939 66605

ENSG00000246695 :RASSF8-

ENSG00000203685:STUM:chrl:+:2267 ENSG00000115657: ABCB6:chr2:- ASl:chrl2:-

88366:226788375:226784682:22678970 :220081373:220081554:220081187: :26109159:26109280:26099068:261

6 220082846 09571

ENSG00000128973 :CLN6 :chrl 5 : - ENSG00000136682:CBWD2:chr2:+ ENSGOOOOO 197467: COL 13 A1 :chrl

:68503893:68504079:68503656:6850662 : 114228609: 114228666: 114220071 : 0:+:71690155:71690308:71689843:

7 114239753 71695105

ENSGOOOOOO 11347: SYT7 : chrl 1 : - ENSGOOOOO 186635 : ARAP1 :chrl 1 : -

ENSG00000058453 :CROCC:chrl :+: 172 :61305615:61305738:61300596:613 :72403797:72403830:72399582:724 96279: 17296429: 17294913 : 17296747 18855 04369

ENSG00000125772:GPCPDl:chr20 ENSG00000095203 :EPB41L4B :chr 9:-

ENSG00000168958:MFF:chr2:+:228217 :5566839:5566915:5564968:557397 : 111945008: 111945077: 111938976:

229:228217289:228205096:228220392 2 111954557

ENSG00000079974 :RABL2B :chr22 ENSG00000072310:SREBFl:chrl7:

ENSG00000165495 :PKN0X2:chrl 1 :+: 1 25279934:125281761:125267958:12529 :51221466:51221714:51220779:512 : 17720861 : 17720905 : 17720771 : 177 8907 21928 21009

ENSG00000166073:GPR176:chrl5:

ENSGOOOOO 164896 :FASTK:chr7:- ENSG00000114956:DGUOK:chr2:+ : 150775648: 150775788: 150775179: 1507 :40099206:40099398:40094455:402 :74166036:74166149:74154179:741 76586 12055 84251

ENSG00000120616:EPCl:chrl0:- ENSG00000079841:RIMSl:chr6:+: ENSGOOOOO 106603 : C0A1 :chr7 :- : 32562849:32562966:32562209:3257362 73005639:73005669:73001749:7301 :43688198:43688251:43684998:437 5 6960 69027

ENSG00000245958:RP11- ENSG00000151239:TWFl:chrl2:- ENSG00000160781:PAQR6:chrl:-

33B 1.1 :chr4 :+: 120449894: 120449944 : 12 :44199633:44199688:44198375:442 : 156215325: 156215452: 156215068:

0434125:120471533 00023 156215913

ENSGOOOOO 154134 :R0B03 :chrl 1 :+: 12 ENSG00000182923 :CEP63 :chr3 :+: ENSG00000075043 :KCNQ2 :chr20 :-

4748193:124748332:124747554:124748 134266176:134266314:134265130:1 :62062692:62062722:62059788:620

479 34267903 65161

ENSG00000271793:RP11-

ENSG00000178104:PDE4DIP:chrl:- 321N4.5:chr6:- ENSG00000117153 :KLHL12:chrl:- : 144855739: 144855883: 144852499: 1448 :86277251 : 86277295 : 86267778 :862 :202865981:202866088:202863877: 56815 81854 202878137 ENSGOOOOO 147044: CASK hrX: - ENSG00000104490:NCALD:chr8:- ENSG00000116171 :SCP2:chrl:+:53 :41481869:41481887:41469278:4148585 : 102792151:102792207: 102731876: 458929:53461672:53453808:534805 6 102928036 61

ENSG00000137312:FLOTl:du6> ENSG00000131626:PPFIA1 :chrl 1 : ENSG00000065609:SNAP91:chr6:- :30709568:30709644:30709110:3070992 +:70212046:70212073:70208594:70 : 84265861 : 84265964 : 84264004 : 842

3 218320 69822

ENSG00000176731:C8orf59:chr8:- ENSG00000085871 :MGST2:chr4:+: ENSG00000152726:FAM2 IB xhrlO :86131464:86131592:86129731:8613253 140599696:140599796:140587231:1 :+:47933806:47933959:47929897:4

4 40616350 7935487

ENSG00000106052:TAXlBPl:chr7 ENSG00000185158:LRRC37B:chrl

ENSG00000034053:APBA2:chrl5:+:293 :+:27855967:27856013:27839709:2 7:+:30347715:30347822:30335151:

86480:29386516:29385423:29390692 7867356 30348411

ENSG00000185985:SLITRK2:chrX ENSG00000186231:KLHL32:chr6:

ENSG00000162066:AMDHD2:chrl6:+: :+: 144903522: 144903671: 14490340 +:97533001:97533217:97489475:97 2577573 :2577616:2571124:2577773 2:144903900 561658

ENSG00000169255:B3GALNTl:ch

ENSG00000101150:TPD52L2:chr2 r3:-

ENSG00000196586:MY06:chr6:+:7657 0:+:62517368:62517395:62514173: : 160807747: 160807850: 160804576:

7147:76577240:76576822:76580363 62518916 160818926

ENSG00000115525: ST3GAL5:chr2

ENSG00000133687:TMTCl:chrl2:- ENSG00000241370:RPP21:chr6:+:3 :29736339:29736507:29725151:2975711 0313267:30313706:30313175:30314 :86078386:86078826:86075327:860 0 208 79982

ENSG00000196295:AC005154.6:chr7:- ENSG00000166592:RRAD:chrl6:-

:30601081:30601744:30590397:3060334 ENSG00000164828:SUNl:chr7:+:8 :66957418:66957623:66956256:669

6 89156:889240:883157:889559 58712

ENSG00000213983:APlG2:chrl4:- ENSGOOOOO 144218 : AFF3 : chr2 : - :24031170:24031275:24030844:2403149 ENSG00000007541:PIGQ:chrl6:+: : 100627958: 100628033 : 100625394: 6 631198:631341:630972:632247 100720863

ENSG00000078487:ZCWPW1 :chr7

ENSG00000137802:MAPKBPl:chr

ENSG00000165949:IFI27:chrl4:+:9458 15:+:42105527:42105545:42105299 : 100013597: 100013717: 100007167:

2126:94582131:94581226:94582131 :42105818 100017252

ENSG00000226686 :LINCO 1535 :chr ENSGOOOOO 119661 :DNAL 1 :chrl4 :

ENSG00000183963:SMTN:chr22:+:314 19:+:37746800:37746884:37743084 +:74128689:74128745:74121588:74

96870:31496939:31495882:31500301 :37753443 138244

ENSG00000148482:SLC39A12:chr ENSG00000079841:RIMSl:chr6:+:

ENSG00000090905:TNRC6A:chrl6:+:2 10:+: 18282112: 18282220: 18280232 72993749:72993821:72970470:7300

4788253:24788679:24769681:24800552 :18284584 1636

ENSG00000100372:SLC25A17:chr

22:- ENSG00000139323:POClB:chrl2:-

ENSG00000101333:PLCB4:chr20:+:944 :41190517:41190584:41188680:411 :89885712:89885892:89866052:899

0281:9440457:9438136:9449217 95026 18896

ENSG00000058404 : CAMK2B : chr7

ENSG00000169064:ZBBX:chr3:- ENSG00000090661 :CERS4 :chrl9 :+ : 166969913 : 166969999: 166960431 : 1670 :44272420:44272465:44270653:442 :8275566:8275746:8274378:831595 00025 74237 9

ENSG00000168314:MOBP:chr3 :+: ENSG00000126777:KTNl:chrl4:+:

ENSG00000112320:SOBP:chr6:+: 10785 39540957:39541023:39521614:3955 56130672:56130759:56128330:5613 4662: 107854814: 107827631 : 107954717 4873 3958 ENSG00000134779:TPGS2:chrl8:- ENSG00000134262:AP4Bl:chrl:- ENSG00000015153:YAF2:chrl2:- :34380160:34380274:34367042:3438780 : 114440461 : 114440565 : 114438660 : :42592937:42593037:42555567:426 9 114441339 31400

ENSG00000091129:NRCAM:chr7:- ENSG00000148634:HERC4:chrl0:- ENSG00000135838:NPL:chrl:+:18 : 107880402: 107880614: 107875132: 1079 :69718869:69718893:69716733:697 2775279:182775666:182772906:182 53108 26439 781290

ENSG00000257218:GATC:chrl2:+:120 ENSG00000213599: SLX1A- ENSG00000047849:MAP4:chr3:-

892735:120892833:120884632:1208948 SULTlA3:chrl6:+:30212516:30212 :47910703:47910817:47908828:479

78 614:30212427:30214010 12302

ENSGOOOOO 125676 :THOC2 :chrX:- ENSG00000184916:JAG2:chrl4:- ENSGOOOOO 112651 :MRPL2 :chr6 :- : 122747249: 122747407: 122745367: 1227 : 105617327: 105617441: 105617248: :43023282:43023356:43022224:430 47902 105617619 25802

ENSG00000110076 :NRXN2:chrl 1 :

ENSG00000134716:CYP2J2:chrl:-

ENSG00000125648:SLC25A23:chrl9:- :64421167:64421194:64419626:644 :60370037:60370188:60366775:603

:6438457:6438545:6436475:6444161 27803 70542 ENSG00000112983:BRD8:chr5:- ENSG00000118518:RNF146:chr6:+ ENSG00000130164:LDLR:chrl9:+: : 137497484: 137497553: 137496757: 1374 : 127601660: 127601749: 127601485: 11238683:11238761:11234020:1124 98818 127607760 0188

ENSG00000141644:MBDl:chrl8:- ENSG00000197558:SSPO:chr7:+:l ENSG00000107771 :CCSER2 :chrlO :

:47801739:47801814:47801615:4780196 49522888:149523027:149522480:14 +:86259630:86259715:86185649:86

9 9523163 273204

ENSG00000135083:CCNJL:chr5:- ENSG00000187118:CMCl:chr3:+:2 ENSGOOOOO 177410 :ZF AS 1 : chr20 : + : 159707531:159707745: 159686778: 1597 8304781:28304871:28283392:28357 :47897439:47897501:47895745:479 38864 823 05581

ENSG00000100320:RBFOX2:chr22

ENSG00000197971:MBP:chrl8:-

ENSG00000197122:SRC:chr20:+:36011 :74700450:74700483:74697166:747 :36152151:36152191:36142608:361 021:36011189:35993680:36012552 00832 55934 ENSG00000073921 :PICALM:chrl 1 : - ENSG00000163517:HDACll:chr3: ENSG00000156958:GALK2:chrl5: :85689112:85689136:85687725:8569217 +: 13538235: 13538352: 13525064: 13 +:49574183:49574282:49531564:49 1 543370 584523

ENSG00000114388:NPRL2:chr3:- ENSG00000074054:CLASPl:chr2:- ENSGOOOOO 162613 :FUBP 1 : chr 1 : -

:50387095:50387259:50386441:5038736 : 122176197: 122176305: 122168545: :78413137:78413232:78412261:784

1 122182714 14839

ENSG00000122678:POLM:chr7:- ENSGOOOOO 143393 :PI4KB : chrl : -

ENSG00000115760 :BIRC6:chr2:+:3281 :44116107:44116228:44114129:441 : 151282686: 151282731:151280277: 5872:32816045:32800433:32818981 18354 151288048

ENSG00000280670:CCDC163:chrl

ENSG00000117245 :KIF17:chrl :-

ENSG00000139531:SUOX:chrl2:+:563 :21011301:21011513:21009377:210 :45961089:45961145:45960838:459

93116:56393242:56391507:56395995 12538 62227

ENSG00000133460:SLC2All:chr2 ENSG00000135127:BICDLl:chrl2:

ENSG00000198838:RYR3:chrl5:+:3413 2:+:24224681:24224833:24219358: +: 120512246: 120512390: 120510533

5688:34135775:34134236:34137062 24224945 :120518690

ENSG00000144504:ANKMYl:chr2

ENSG00000055483:USP36:chrl7:- ENSG00000166377:ATP9B:chrl8:+

:76793867:76793961:76783740:7679448 :241421599:241421678:241420514: :76973961:76974038:76967012:770

1 241439374 13380

ENSG00000066117: SMARCD 1 : chrl 2 :+ ENSG00000149131 :SERPING1 xhr ENSG00000239672:NMEl:chrl7:+: :50481145:50481268:50480661:5048366 ll:+:57367351:57367850:57365794 49231585:49231805:49231085:4923 6 :57369507 3011

ENSG00000050405:LIMAl:chrl2:- ENSG00000070476 :ZXDC:chr3 : - ENSG00000110921 :MVK:chrl2:+:l :50579172:50579231:50575820:5058961 : 126160607: 126160789: 126158570: 10019199:110019355:110017751:11 2 126178495 0023826

ENSG00000204580:DDRl:chr6:+:3 ENSG00000126249:PDCD2L:chrl9

ENSG00000006125:AP2Bl:chrl7:+:339 0853401:30853457:30852487:30856 :+:34895834:34895895:34895443:3

97875:33997917:33984810:33998772 464 4900065

ENSG00000140400:MAN2Cl:chrl

ENSG00000198718 :T0GARAM1 :chrl4 ENSG00000117280:RAB29:chrl:- 5:- :+:45501425:45501579:45497532:45512 :205741623:205741695:205739982: :75655550:75655631:75655089:756 888 205743960 56828

ENSG00000138363:ATIC:chr2:+:2 ENSG00000106078:COBL:chr7:-

ENSG00000119383 :PTPA:chr9:+: 13189 16184387:216184454:216182956:21 :51150754:51150925 :51111389:511 0242:131890347:131882889:131891263 6190709 52862

ENSG00000166979:EVAlC:chr21: ENSGOOOOO 140474 :ULK3 xhrl 5 : -

ENSG00000176715:ACSF3:chrl6:+:891 +:33829904:33830028:33785321:33 :75130492:75130514:75130139:751

67069:89167755:89160404:89169011 840003 30606

ENSG00000151690:MFSD6:chr2:+: ENSG00000166411:IDH3A:chrl5:+

ENSG00000102125:TAZ:chrX:+: 153648 191364557:191364582:191362445:1 :78449249:78449504:78447593:784 043:153648085:153647962:153648370 91364740 49889 ENSG00000099889:ARVCF:chr22:- ENSG00000157764:BRAF:chr7:- ENSG00000165629:ATP5Cl:chrl0: : 19964228: 19964246: 19963280: 1996493 : 140434416: 140434570: 140426316: +:7848936:7848973:7844817:78496 7 140439611 21

ENSG00000072501:SMClA:chrX:- ENSG00000179364:PACS2:chrl4:+ ENSGOOOOO 163516 : ANKZF 1 :chr2 :

:53441706:53441819:53440385:5344944 : 105852021: 105852054: 105851324: +:220100195:220100307:220100034

0 105856297 :220100429

ENSG00000173210:ABLIM3:chr5:+:14 ENSG00000138069:RABlA:chr2:- ENSG00000171606:ZNF274:chrl9:

8618810:148618840:148612863:148619 :65325104:65325200:65315824:653 +:58697063:58697205:58695365:58

321 57026 698313

ENSG00000160753 :RUSC1 :chrl :+: 1552 ENSG00000182872:RBM10:chrX:+ ENSGOOOOO 159063 :ALG8 xhrl 1 : -

95391:155295463:155295281:15529565 :47038501:47038562:47035985:470 :77838403:77838485:77835260:778

4 40613 50539 ENSG00000153391:IN080C:chrl8:

ENSG00000119723 :COQ6:chrl4:+:

ENSG00000092108:SCFDl:chrl4:+:310 :33059263:33059375:33058313:330 74426117:74426225:74425927:7442

97414:31097485:31091605:31099682 77682 7875

ENSG00000151090 :THRB : chr3 : - ENSG00000143374:TARS2:chrl:+:

ENSG00000197302 :ZNF720 :chrl6 :+: 31 :24270428:24270492:24231825 :243 150468957:150469104:150464965:1

734578:31734674:31724756:31765086 78790 50470005

ENSG00000125962:ARMCX5:chrX:+:l ENSG00000060237:WNKl:chrl2:+ ENSG00000106348:IMPDHl:chr7:-

01855847:101855960:101854775:10185 : 1013618: 1013660: 1006847: 101701 : 128040885: 128040945: 128040593:

6391 2 128041068

ENSG00000157637:SLC38A10:chr ENSG00000073921 :PICALM:chrl 1

ENSG00000081760:AACS:chrl2:+:1256 17:-

03186:125603311:125599103:12561854 :79223869:79223893:79220861:792 :85687665:85687725:85670103:856

8 25292 92171

ENSG00000065809:FAM107B:chrl

ENSG00000203797:DDO:chr6:- 0:-

ENSG00000143252:SDHC:chrl:+: 16129 : 110734493: 110734669: 110729645: : 14595320: 14595386: 14572514: 146 3403:161293460:161284215:161310383 110736669 13922 ENSG00000114988:LMAN2L:chr2:- ENSG00000040933 :INPP4A:chr2:+ ENSG00000162086:ZNF75A:chrl6: : 97378843:97378876:97377762: 9739925 :99165417:99165432:99163157:991 +:3366911:3367022:3361948:33671 5 69248 89

ENSG00000214078:CPNEl:chr20:- ENSG00000138964 :PARVG:chr22 : ENSG00000144290:SLC4A10:chr2: :34246851:34246936:34220845:3425268 +:44579197:44579288:44569071:44 +: 162814996: 162815065: 162807358 1 581687 : 162820644

ENSG00000147099:HDAC8:chrX:- ENSG00000064787 :BCAS 1 :chr20: -

ENSG00000128739:SNRPN:chrl5:+:25 :71708782:71708891:71684581:717 :52583444:52583612:52570234:526 219788:25220104:25219603:25221451 87738 01825 ENSG00000197226 :TBC1D9B :chr5 : - ENSG00000114098: ARMC8:chr3:+ ENSG00000104859:CLASRP:chrl9 : 179294444: 179294495: 179292888: 1792 : 137907242: 137907372: 137906441: :+:45571272:45571316:45570852:4 94777 137940767 5572323

ENSG00000254788:CKLF- ENSG00000172803 :SNX32:chrl 1 :+ ENSG00000124788:ATXNl:chr6:-

CMTM1 :chrl6:+:66592092:66592251 :6 :65618798:65618874:65618326:656 : 16326624:16328701 :16307090: 164

6586696:66611006 19110 86202

ENSG00000162650:ATXN7L2:chrl:+:l ENSG00000123349:PFDN5:chrl2:+ ENSG00000111554:MDMl:chrl2:- 10034648: 110034726: 110034339:11003 :53690027:53690059:53689423:536 :68710360:68710390:68710033:687 5207 91633 15126

ENSG00000167524:SGK494:chrl7:

ENSG00000175267:VWA3A:chrl6:

ENSG00000148655:C10orfll:chrl0:+:7 +:22161107:22161252:22159627:22 :26938160:26938271:26937717:269

8084158:78084243:77818541:78316966 162015 38410

ENSG00000168393:DTYMK:chr2:- ENSG00000186635 : ARAP1 :chrl 1 :- ENSG00000132600 :PRMT7 :chrl6:

:242621333:242621748:242618064:2426 :72443559:72443642:72438217:724 +:68381113:68381197:68380183:68

25183 63372 386150

ENSG00000123562 :MORF4L2 :chrX:- ENSG00000118785 :SPPl:chr4:+:88 ENSG00000171204:TMEM126B:ch : 102939608: 102939657: 102931979: 1029 901544:88901586:88901278:889026 rll:+:85342188:85342360:8533973 40098 26 2:85342730

ENSG00000006071 : ABCC8 :chrl 1 : - ENSG00000146282:RARS2:chr6:- ENSG00000164329:PAPD4:chr5:+: : 17452360: 17452506: 17450217: 1745375 :88258308:88258364:88255417:882 78938666:78938733:78908898:7894 0 65125 0945

ENSG00000148341:SH3GLB2:chr9:- ENSG00000080503 : SMARCA2 xhr ENSG00000135298:ADGRB3:chr6: : 131784560: 131784702: 131777183: 1317 9:+:2159813:2159909:2158594:216 +:69640450:69640561:69349324:69 90370 1685 653721

ENSG00000181045:SLC26All:chr ENSG00000163995:ABLIM2:chr4:-

ENSG00000215039:CD27-ASl:chrl2:- 17:+:78222373:78222473:78222056 :8021928:8022030:8010829:803138

:6560058:6560146:6557903:6560634 :78225127 2

ENSG00000076685:NT5C2:chrl0:-

ENSG00000122507:BBS9:chr7:+:33390 : 104899162: 104899236: 104866463: ENSG00000214021 :TTLL3 :chr3 :+:

830:33390935:33388782:33397466 104934614 9860505:9860604:9859443:9862229 ENSG00000271698:GS1-

ENSG00000087008:ACOX3:chr4:- 393G12.13:chr8:-

ENSG00000082805:ERCl:chrl2:+:1221 :8372634:8372721:8368807:838321 : 145577896: 145577991 : 145577809:

380:1221464:1219513:1225031 8 145578276

ENSG00000012822:CALCOC01:ch

ENSG00000070814:TCOFl:chr5:+:1497 rl2:-

71106:149771220:149769586:14977151 ENSG00000103254:FAM173A:chrl :54106558:54106630:54105905:541

9 6:+:772083:772134:771941:772308 06883 ENSG00000147687:TATDNl:chr8:

ENSG00000080822:CLDNDl:chr3> ENSG00000008441:NFIX:chrl9:+:

:98240496:98240547:98240281:9824138 13198802:13198950:13192669:1320 : 125530982: 125531122: 125528271:

5 5448 125535177

ENSG00000266173 : STRAD Axhrl

ENSG00000135597:REPSl:chr6:- 7:-

ENSG00000107077:KDM4C:chr9:+:698 : 139247537: 139247618: 139242261: :61800657:61800686:61791468:618 1841:6982765:6981118:6984165 139251113 05693 ENSG00000125814 :NAPB :chr20 : - ENSG00000107719:PALDl:chrl0: ENSG00000145730:PAM:chr5:+:10 :23375775:23375822:23375636:2337770 +:72285678:72285892:72238815:72 2363885:102363942:102361038:102 8 288984 364590

ENSG00000126106:TMEM53:chrl:- ENSG00000182923 :CEP63 :chr3 :+: ENSG00000135093:USP30:chrl2:+: :45120611 :45120881 :45111136:4512584 134276983:134277189:134270854:1 109495730: 109495913 : 109494596: 1 5 34280218 09505328

ENSG00000219626 :FAM228B :chr2 ENSG00000140326:CDANl:chrl5:-

ENSG00000124140:SLC12A5:chr20:+:4 :+:24384375:24384483:24369956:2 :43018294:43018358:43017868:430

4685535:44685550:44685203:44685808 4387067 18507

ENSG00000179912:R3HDM2:chrl

ENSG00000079277:MKNK1 xhrl :- 2:- ENSG00000048991:R3HDMl:chr2: :47051545 :47051646:47049001 :4705978 :57686354:57686450:57682823:576 +: 136399105: 136399174: 136396692 4 89181 : 136402948

ENSG00000213995 :NAXD xhrl 3 :+

ENSG00000188933 :USP32P1 :chrl7:+: 1 : 111274562: 111274713 : 111267994: ENSG00000125388:GRK4:chr4:+:3 6695140:16695367:16690436:16699356 111286891 021367:3021558:3015555:3024140 ENSG00000143106:PSMA5 xhrl :- ENSG00000198561:CTNNDl:chrl ENSG00000106603 : COA1 :chr7 :- : 109957858: 109957985: 109954806: 1099 l:+:57573932:57573950:57573507: :43705256:43705321:43696868:437 68923 57574386 69027

ENSG00000197467:COL13Al:chrl ENSG00000240207:RP11-

ENSG00000125337:KIF25:chr6:+: 16844 0:+:71658452:71658518:71655332: 379F4.4:chr3:+: 158451739: 1584518 2648: 168442831 : 168440896: 168445506 71662503 26:158450317:158458177 ENSG00000051108:HERPUDl:chrl6:+: ENSG00000204231 :RXRB :chr6: - 56969315:56969387:56969224:5697059 :33163139:33163231:33162827:331 ENSG00000087274:ADDl:chr4:+:2 8 63346 911065:2911158:2910331:2916610

ENSG00000178104:PDE4DIP:chrl:- ENSG00000226174 : TEX22 xhrl 4 : + ENSG00000087085:ACHE:chr7:- : 144857611 : 144857728: 144857042: 1448 : 105915695: 105915746: 105905076: : 100489954: 100490264: 100488959: 59758 105916394 100490785

ENSG00000243696:RP5-966M1.6:chr3:- ENSG00000154222:CC2DlB:chrl:- ENSG00000170390:DCLK2:chr4:+:

:52858857:52858974:52858581:5285990 :52825376:52825492:52825206:528 151120179:151120230:151119255:1

1 25745 51124946

ENSG00000101247:NDUFAF5:chr ENSG00000123146:ADGRE5:chrl9

ENSG00000134759:ELP2:chrl8:+:3371 20:+: 13795063: 13795161: 13789548 :+: 14499513: 14499630: 14499312:1 8757:33718835:33718389:33721099 :13797520 4501735 ENSG00000116337:AMPD2 xhrl :+: 110 ENSG00000131503 : ANKHD 1 :chr5 : ENSG00000242808:SOX2- 163535:110163888:110162900:1101679 +: 139914946: 139915123: 13990938 OT:chr3:+: 181432972: 181433080:1 24 1:139916922 81417671:181457356

ENSG00000169241:SLC50Al:chrl:+:15 ENSG00000151092 :NGLY 1 : chr3 : - ENSG00000111790:FGFR10P2:chr

5109303:155109427:155108852:155110 :25781067:25781290:25775473 :257 12:+:27113447:27113561:27110676

036 92588 : 27116274

ENSG00000101333:PLCB4:chr20:+ ENSG00000135317:SNX14:chr6:-

ENSG00000083535:PIBFl:chrl3:+:7346 :9457363:9457400:9454012:945956 :86248555:86248582:86246642:862

7921:73468087:73428293:73482668 7 51702

ENSG00000179912:R3HDM2:chrl

ENSG00000130559:CAMSAPl:chr9:- 2:- ENSG00000135424:ITGA7:chrl2:- : 138757177: 138757210: 138754454: 1387 :57682791:57682823:57677839:576 :56094045:56094177:56093773:560 58301 89181 94682

ENSG00000090097:PCBP4:chr3:- ENSG00000103175:WFDCl:chrl6: ENSG00000196387:ZNF140:chrl2: :51995764:51995910:51995320:5200134 +:84351877:84351961:84346759:84 +: 133677572: 133677639: 133660147 1 353036 :133682095

ENSG00000131791 :PRKAB2 xhrl : ENSG00000100523:DDHDl:chrl4:

ENSG00000132781 :MUTYH:chrl : - :45799084:45799275:45798996:4580006 : 146638076: 146638197: 146634152: :53560033:53560162:53558650:535 2 146643567 70400

ENSG00000136717:BINl:chr2:- ENSG00000133884 :DPF2 xhrl 1 :+: ENSG00000077380:DYNClI2:chr2: : 127810997: 127811021: 127809938: 1278 65112050:65112092:65111540:6511 +: 172569276: 172569336: 172563887 15048 3136 :172571837 ENSG00000073417:PDE8A:chrl5:+

ENSG00000111679:PTPN6:chrl2:+:706 ENSG00000099864:PALM:chrl9:+: :85619092:85619149:85610435:856 6816:7066948:7065731:7069089 740351:740483:736078:746284 26786 ENSG00000095637:SORBSl:chrl0:- ENSG00000168958:MFF:chr2:+:22 ENSG00000110274:CEP164:chrll: :97131740:97131806:97127456:9713572 8207460:228207535:228205096:228 +: 117253511 : 117253658: 117252584 9 217229 :117261492

ENSG00000082898 :XP01 :chr2 : - ENSG00000102878:HSF4:chrl6:+:6

ENSG00000143797:MBOAT2:chr2:- :61726847:61727029:61726048:617 7203181 :67203251 :67203004:67203 : 9002400 :9002452: 9000894 : 9002719 49745 533 ENSG00000273066:RP11- ENSGOOOOO 131323 : TRAF3 : chrl 4 :+ ENSG00000167601:AXL:chrl9:+:4 216L13.19:chr9:+: 139703706: 13970388 : 103355896: 103355971: 103352606: 1744374:41744514:41744059:41745 1:139702778:139704139 103357661 068 ENSG00000105397:TYK2:chrl9:- ENSG00000249307 :LINCO 1088 xhr ENSG00000125347:IRFl:chr5:- : 10464203 : 10464322: 10461644: 1046471 4:+:80116989:80117086:79894206: : 131821942: 131822065: 131820189:

7 80227844 131822248

ENSG00000198301:SDADl:chr4:- ENSG00000115998:C2orf42:chr2:-

ENSG00000133318:RTN3:chrll:+:6347 :76895228:76895286:76894544:768 :70392223:70392324:70387919:703 2322:63472379:63449250:63486173 96896 92659 ENSG00000140374 :ETFA:chrl 5 : - ENSG00000116001 :TIA1 :chr2:- ENSG00000088367:EPB41Ll:chr20 :76587931 :76588078:76585041 :7660369 :70456190:70456223:70454954:704 :+:34761685:34761876:34700402:3 0 56395 4763472

ENSG00000136717:BINl:chr2:- ENSG00000089159:PXN:chrl2:- ENSG00000242588:RP11- : 127815048: 127815177: 127808819: 1278 : 120654075: 120654919: 120653464: 274B21.14:chr7:+: 128220052: 12822 16586 120659425 0148:128218987:128231903

ENSG00000132676:DAP3 xhrl :+: 1 ENSGOOOOO 187609:EXD3 :chr9 :-

ENSG00000181027:FKRP:chrl9:+:4725 55706796:155706854:155701824:15 : 140269063 : 140269215 : 140268051 : 1771 :47251974 :47251345 :47258668 5707947 140277764 ENSG00000005379:TSPOAPl:chrl7:- ENSG00000133142 :TCEAL4 :chrX: ENSG00000049618:ARIDlB:chr6:+ :56402894:56403074:56402363:5640494 +: 102840786: 102841219: 10284055 : 157495980: 157496139: 157495251:

8 2:102841576 157502102

ENSG00000158062 :UBXN11 :chrl :- ENSG00000196169:KIF19:chrl7:+: ENSGOOOOO 151612 :ZNF827 : chr4 : - :26628184:26628213:26624553:2663308 72342516:72342663:72341094:7234 : 146791396: 146791630: 146770713: 2 3915 146806829

ENSG00000171311:EXOSCl:chrl0

ENSG00000168916 :ZNF608 : chr5 : - ENSGOOOOO 164211 : ST ARD4 :chr5 : - : 124036706: 124036962: 123985390: 1240 : 110842027: 110842077: 110837786: :99198419:99198460:99197507:992 79776 110843026 00927

ENSG00000145388:METTL14:chr4:+:l ENSG00000249240:AC069368.3:ch ENSG00000179943:FIZl:chrl9:- 19626765: 119626976: 119625206:11963 rl5:+:65152092:65152197:6514723 :56106985:56107100:56105012:561 1152 6:65223019 08937

ENSG00000152578:GRIA4:chrll:+:105 ENSG00000162631:NTNGl:chrl:+: ENSG00000163618:CADPS:chr3:-

842640:105842755:105836788:1058450 107866903:107867544:107691461:1 :62530522:62530534:62522256:625

36 07937775 35577

ENSG00000184381 :PL A2G6 : chr22 : - ENSG00000088367:EPB41Ll:chr2 ENSG00000147813:NAPRT:chr8:- : 38523413:38523465:38522456: 3852427 0:+:34761685:34761876:34742818: : 144657399: 144657515: 144657263: 5 34763472 144657592

ENSG00000122203 :KIAA1191 :chr5 :- ENSG00000136280:CCM2:chr7:+:4 ENSGOOOOO 157045 :NTAN1 :chrl6: - : 175786464: 175786570: 175779751:1757 5104061:45104245:45078025:45109 : 15141711:15141777: 15141407: 151 86813 424 49747

ENSG00000141040:ZNF287:chrl7:

ENSG00000260807:RP11- ENSG00000050426 :LETMD 1 :chrl2

161M6.2:chrl6:- : 16470642: 16471243: 16469936: 164 :+:51449932:51450028:51447643:5

: 1029600: 1029758: 1027093 : 1031144 72265 1450132 ENSG00000162482:AKR7A3:chrl:- ENSG00000120709:FAM53C:chr5: ENSG00000072518:MARK2:chrl 1 : : 19611511:19611608: 19611279: 1961238 +: 137677497: 137677555: 13767399 +:63673559:63673586:63672515:63 1 6:137680513 675731

ENSG00000163393:SLC22A15:chrl:+:l ENSG00000203780:FANKl:chrl0: ENSG00000126858:RHOTl:chrl7: 16569513: 116569643 : 116563506: 11657 +T27697622: 127697700: 12769711 +:30499955:30500079:30498120:30 4023 9:127697941 500849

ENSG00000074964:ARHGEF10L:chrl: ENSG00000163291:PAQR3:chr4:- ENSG00000163319:MRPS18C:chr4 +: 17939552: 17939669: 17934472: 179425 :79856274:79856437:79851479:798 :+:84379498:84379582:84378111:8 88 60193 4382125

ENSGOOOOO 100350 :F0XRED2 :chr22: - ENSG00000135127:BICDLl:chrl2: ENSGOOOOO 181192:DHTKD 1 xhrl :36900144:36900414:36897454:3690056 +: 120510314: 120510533 : 12050960 0:+: 12154898: 12155063: 12150014:

1 5:120518690 12159671 ENSG00000075292:ZNF638:chr2:+ ENSGOOOOO 185222 :WBP5 :chrX:+:

ENSG00000160801:PTHlR:chr3:+:4694 :71575556:71577401:71558995:715 102612010:102612089:102611534:1

4238:46944280:46943350:46944759 82848 02612542

ENSG00000239382:ALKBH6:chrl9:- ENSG00000204653:ASPDH:chrl9:-

:36504229:36504324:36503991:3650507 ENSG00000249915:PDCD6:chr5:+: :51016183:51016268:51015547:510

6 304291:306869:272887:314531 17747

ENSG00000139620 :KANSL2 :chr 12 : - ENSG00000128596:CCDC136:chr7 ENSGOOOOO 120658 :EN0X1 :chrl 3 : -

:49072818:49072933:49065745:4907343 :+: 128446741: 128446912: 12844595 :43986980:43987124:43986189:440

7 5:128457811 58144

ENSG00000165521:EML5:chrl4:-

ENSG00000148204:CRB2:chr9:+: 12612 ENSG00000064666:CNN2:chrl9:+: :89082485:89082586:89082198:890 9851:126129965:126129636:126132386 1036128:1036245:1032695:1036414 83069 ENSG00000099338:CATSPERG:ch ENSG00000088387:DOCK9 :chrl 3 :-

ENSG00000137094:DNAJB5:chr9:+:34 rl9:+:38860611:38860704:3885877 :99497582:99497626:99489863:995

990664:34990809:34989828:34993196 7:38860798 00845

ENSG00000072041 : SLC6A15 :chrl

ENSG00000019144 :PHLDB 1 :chrl 1 :+: 1 ENSG00000111711 :G0LT1B :chrl2 2:- 18512971:118513112:118509969:11851 :+:21660050:21660085:21659910:2 :85285610:85286087:85279847:853 4517 1661316 06301

ENSG00000169221:TBClD10B:chr

16:- ENSG00000114416:FXR1 :chr3 :+: 1

ENSG00000196476 : C20orf96 :chr20 : - :30376815:30376915:30371162:303 80688862:180688943:180688146:18 :270199:270317:264722:270899 80548 0693100

ENSG00000205362:MTlA:chrl6:+: ENSG00000139116:KIF21A:chrl2:-

ENSG00000198513:ATLl:chrl4:+:5109 56673175:56673241 :56672678:5667 :39709733:39709772:39705355:397 6712:51096727:51095180:51097649 3770 13707 ENSG00000182473 :EXOC7 :chrl7: - ENSG00000266714 :MYO 15B : chrl ENSG00000110717:NDUFS8:chrll :74086409:74086478:74085401:7408722 7:+:73588057:73588161:73587793: :+:67799618:67799676:67798200:6 3 73588318 7800389

ENSG00000121413:ZSCAN18:chrl9:- ENSG00000158882:TOMM40L:chr ENSG00000185000:DGATl:chr8:-

:58604594:58604765:58601753:5860948 1:+: 161196677: 161196745: 1611963 : 145542690: 145542731 : 145542583 :

1 94:161197673 145544983

ENSG00000251022 :THAP9-AS 1 :chr4 :- ENSGOOOOO 171204 : TMEM126B : ch ENSG00000112320:SOBP:chr6:+:l :83816844:83816927:83816000:8382122 rll:+:85340175:85340306:8533973 07908283 : 107908379: 107827631:10 9 2:85345129 7954717

ENSG00000185864 :NPIPB4 :chrl 6 : - ENSG00000125814:NAPB:chr20:- ENSG00000108352:RAPGEFLl:chr :21851260:21851329:21850631:2185470 :23377708:23377825:23370901:233 17:+:38349177:38349242:38348945 6 83629 :38349915

ENSG00000167110:GOLGA2:chr9:- ENSG00000163995:ABLIM2:chr4:- ENSG00000187164:SHTNl:chrl0:- : 131035063: 131035144: 131030803: 1310 :8021344:8021398:8010829:803138 : 118666137: 118666258: 118646077: 36128 2 118671300

ENSGOOOOO 186001 :LRCH3 :chr3 :+: 1975 ENSG00000137501 : SYTL2:chrl 1 :- ENSG00000103449:SALLl:chrl6:- 92982:197593090:197592342:19759703 :85425455:85425550:85422275:854 :51172598:51176056:51171463:511 0 29832 85076

ENSG00000052126:PLEKHA5:chrl2:+: ENSG00000175224: ATG13 :chrl 1 :+ ENSG00000164038:SLC9B2:chr4:-

19443610:19443730:19440490:1947349 :46685546:46685645:46681035:466 : 103978957: 103979128: 103971539:

5 86398 103987483

ENSG00000140521:POLG:chrl5:- ENSGOOOOO 177182 : CL VS 1 : chr8 :+ : ENSG00000111731:C2CD5:chrl2:- :89861169:89861206:89860767:8986177 62212235:62212841:62200697:6228 :22612425:22612476:22610095:226 1 9163 22642

ENSG00000109339:MAPK10:chr4: ENSG00000079819:EPB41L2 :chr6 :

ENSG00000106976:DNMl:chr9:+:1310 02263 : 131002275 : 131002058: 13100451 :87374182:87374334:87275797:875 : 131190702: 131191266: 131184858: 0 15062 131206235

ENSG00000143434:SEMA6C:chrl:

ENSG00000126091 : ST3 GAL 3 :chrl

ENSG00000101049:SGK2:chr20:+:4221 :+:44365212:44365399:44364935:4 : 151108923: 151109055: 151108639:

1822:42212014:42208701:42213491 4395803 151109332

ENSG00000103351:CLUAPl:chrl6 ENSG00000166111:SVOP:chrl2:-

ENSG00000174628:IQCK:chrl6:+:1974 :+:3554719:3554831:3551089:3556 : 109366180: 109366252: 109354823:

6674:19746772:19745149:19800159 330 109371173

ENSG00000151789:ZNF385D:chr3:

ENSGOOOOO 184787 :UBE2G2 :chr21 : - ENSG00000111731 :C2CD5 :chrl2:- :46207974:46208010:46197332:4622162 22611973 :22672173 :22671071 :226 :21466983:21467162:21462939:214 0 76359 78461 ENSG00000109756:RAPGEF2:chr4:+:l ENSG00000140632:GLYRl:chrl6:- ENSG00000095794:CREM:chrl0:+:

60164925:160164943:160162520:16022 :4871547:4871598:4867698:487287 35490378:35490414:35484142:3549

5493 5 5822

ENSG00000157087:ATP2B2:chr3:- ENSG00000136738:STAM:chrl0:+: ENSG00000284048:RP11- : 10426951 : 10427011 : 10420968: 1042996 17726673:17726749:17702547:1773 5 llP7.6:chr7:+: 150104671: 1501055 0 0025 76:150102405:150107247

ENSG00000109083 :IFT20 :chrl7: - ENSG00000085382:HACEl:chr6:- ENSG00000119689:DLST:chrl4:+:

:26659171:26659408:26659013:2666236 : 105228227: 105228332: 105225192: 75349293:75349327:75348719:7535

5 105231960 5797

ENSG00000136877:FPGS:chr9:+:l ENSG00000133627:ACTR3B:chr7:

ENSG00000070501 :POLB :chr8 :+:42207 30570836:130570984:130570590:13 +: 152480271: 152480327: 152457011 524:42207583:42206608:42213033 0571078 : 152498705 ENSG00000116396 :KCNC4 :chrl :+: 110 ENSG00000171862:PTEN:chrl0:+: ENSG00000139372:TDG:chrl2:+:l 765585:110766522:110754799:1107685 89685269:89685314:89653866:8969 04376913:104376996:104376712:10 96 0802 4377072

ENSG00000145725 :PPIP5K2 :chr5 :+: 10 ENSG00000205517:RGL3:chrl9:- 2518934:102519108:102515889:102520 ENSG00000070047:PHRF1 :chrl 1 :+ : 11513130: 11513217: 11512923: 115 372 :605607:605724:605300:606441 13325 ENSGOOOOO 133315 :M ACROD 1 :chr 11:- ENSG00000152382:TADAl:chrl:-

ENSG00000184371:CSFl:chrl:+: 11045 :63766309:63766344:63766159:637 : 166838681: 166838747: 166833158: 8255:110458318:110453684:110459914 66426 166845396

ENSG00000215908:CROCCP2:chrl

ENSG00000204084 :INPP5B :chrl :- ENSG00000120251:GRIA2:chr4:+: :38397344:38397725:38357126:3840635 158282161:158282276:158281295:1 : 16952847: 16952994: 16952500: 169 9 58283950 53639

ENSG00000105048:TNNTl:chrl9:- ENSG00000173933:RBM4:chrll:+: ENSGOOOOO 149654 :CDH22 :chr20: - : 55652553:55652670:55649442: 5565322 66410920:66411611:66407594:6641 :44806584:44806836:44803716:448 4 3497 15226

ENSG00000164199:ADGRVl:chr5: ENSG00000175581:MRPL48:chrll

ENSG00000168297 :PXK:chr3 :+: 584062 +:90445846:90446038:90398157:90 :+:73500379:73500535:73499037:7 62:58406295:58398690:58410478 459598 3516071 ENSG00000108599:AKAP10:chrl7:- ENSG00000141503:MINKl:chrl7: ENSG00000091129:NRCAM:chr7:- : 19812493: 19812589: 19809545: 1982334 +:4795696:4795807:4795529:47959 : 107878195: 107878213: 107875132: 8 50 107880402

ENSG00000157800:SLC37A3:chr7:

ENSG00000102078:SLC25A14:chr

ENSG00000067798:NAV3:chrl2:+:7859 : 140045015: 140045063: 140037149: X:+: 129474080: 129474327: 1294739 4252:78594371:78593311:78598714 140045668 50:129479155 ENSG00000198185 :ZNF334 :chr20 :- ENSG00000134775 :FH0D3 :chrl 8 : ENSG00000159753:CARMIL2:chrl :45132852:45132998:45131736:4513325 +:33952642:33952707:33935608:34 6:+:67690703:67690784:67690548: 2 081894 67691141

ENSG00000157827:FMNL2:chr2:+: ENSG00000133627:ACTR3B:chr7:

ENSG00000147852:VLDLR:chr9:+:264 153479050:153479071:153476232:1 +: 152549210: 152549336: 152522207

8207:2648347:2647592:2648668 53481951 :152551542

ENSG00000170836:PPMlD:chrl7: ENSG00000104529:EEFlD:chr8:-

ENSG00000087157:PGSl:chrl7:+:7641 +:58700881 :58701110:58678247:58 : 144674816: 144675112: 144672251 : 1032:76411108:76400170:76415626 725252 144679517 ENSGOOOOO 106351 : AGFG2 :chr7 :+: 100 ENSG00000164896:FASTK:chr7:- ENSG00000054267 : ARID4B xhrl : - 154216:100154249:100153358:1001598 : 150776009: 150776108: 150775179: :235344385:235344499:235341228: 81 150776586 235344899

ENSG00000174744:BRMS1 :chrl 1 :- ENSG00000204052:LRRC73:chr6:- ENSGOOOOO 180376 :CCDC66 :chr3 :

:66105713:66106256:66105360:6610824 :43476035:43476158:43475664:434 +:56606364:56606456:56605330:56

4 76497 626997

ENSG00000125462:Clorf61:chrl:- ENSG00000067177:PHKAl:chrX:-

ENSG00000090857:PDPR:chrl6:+:7016 : 156376871: 156376989: 156374393: :71840574:71840751:71839155:718

5204:70165322:70164447:70166053 156396589 42958

ENSG00000196967:ZNF585A:chrl

9:- ENSG00000137965:IFI44:chrl:+:79

ENSG00000132109:TRIM21:chrll:- :37656496:37656598:37647257:376 126238:79126376:79125168:791294 :4409529:4409760:4408220:4410883 60740 49 ENSGOOOOO 147099 :HD AC8 :chrX: - ENSG00000172987:HPSE2:chrl0:- ENSG00000040341 : STAU2 :chr8 :- :71715005:71715118:71684581:7178773 : 100453656: 100453704: 100401697: :74585341:74585477:74529686:746 8 100481413 59017

ENSGOOOOO 110076 :NRXN2 :chrl 1 :- ENSG00000089177:KIF16B:chr20:- ENSGOOOOO 145740: SLC30A5 :chr5 :

:64444464:64444509:64436076:6445311 : 16336974: 16337097: 16316660: 163 +:68412220:68412429:68412041:68

7 51230 414325 ENSG00000117425 :PTCH2 :chrl ENSG00000107317:PTGDS:chr9:+: ENSGOOOOO 131044 :TTLL9:chr20 :+

:45294828:45294984:45294746:4529507 139873674:139873853:139872144:1 :30510765:30510856:30507735:305

3 39874397 12811

ENSGOOOOO 137497:NUMA1 :chrl 1 :

ENSG00000198105:ZNF248:chrl0:- ENSG00000156860:FBRS:chrl6:+:

:38126912:38127039:38122044:3814522 30672624:30672654:30671763:3067 :71723446:71723488:71721900:717

3 3740 23940

ENSG00000005436:GCFC2:chr2:- ENSG00000095794:CREM:chrl0:+ ENSG00000105426:PTPRS:chrl9:-

:75919102:75919226:75917845:7592136 :35477127:35477316:35437419:354 :5218797:5218809:5218543:521932

6 95822 0

ENSG00000147813:NAPRT:chr8:- ENSG00000145247:OCIAD2:chr4:- ENSGOOOOO 165061 :ZMAT4 : chr8 : - : 144657399: 144657515: 144657070: 1446 :48899820:48899852:48896070:489 :40438683:40438780:40389757:405 57592 06500 32222

ENSG00000103174:NAGPA:chrl6:

ENSG00000072310:SREBFl:chrl7:- ENSG00000088387:DOCK9 :chrl 3 :- : 17726831 : 17726921 : 17723835 : 1774004 :5078297:5078399:5078186:507888 :99498177:99498314:99489863:995 0 0 00845

ENSG00000165795:NDRG2:chrl4:

ENSG00000112983:BRD8:chr5:- ENSG00000006740 : ARHGAP44 : ch : 137502206: 137502416: 137501797: 1375 :21492188:21492255:21490341:214 rl7:+: 12876618: 12876636: 1286221 03622 93187 4:12877405

ENSG00000075711 :DLG1 :chr3 :- ENSGOOOOO 110675 :ELMODl:chrl

ENSG00000004766:VPS50:chr7:+:9293 : 196803456: 196803556: 196802741: 1:+: 107524897: 107524948: 1075211

2771:92932862:92926555:92938135 196807921 29:107535750

ENSG00000139220 :PPFIA2 : chrl 2 : - ENSG00000068001 :HYAL2:chr3 :-

ENSG00000109685 :NSD2 :chr4 :+: 19440 :81676788:81676818:81675229:816 :50358796:50359204:50357966:503

65:1944292:1941505:1952798 88613 60083

ENSG00000170919:TPT1- ENSG00000008441:NFIX:chrl9:+: ENSG00000168487:BMPl:chr8:+:2

ASl:chrl3:+:45953329:45953470:45952 13189426:13189549:13186485:1319 2056776:22056900:22054933:22058

806:45954060 2493 630

ENSG00000272752: STAG3L5P- PVRIG2P- ENSG00000140995:DEF8:chrl6:+: ENSG00000167037:SGSMl:chr22:

PILRB:chr7:+:99950995:99951106:9995 90015824:90015921:90015222:9002 +:25264689:25264822:25255807:25 0893:99952765 0650 272543

ENSG00000115977: AAKl:chr2:- ENSG00000130294:KIFlA:chr2:- :69709842:69709944:69708093:6973270 :241711986:241712013:241710521: ENSG00000132530:XAFl:chrl7:+: 0 241712530 6662574:6662838:6661543:6662980

ENSG00000120029:C10orf76:chrl0:- ENSG00000164548:TRA2A:chr7:- : 103716353: 103716480: 103699695: 1037 :23561750:23562051:23561459:235 ENSG00000011304:PTBPl:chrl9:+ 34968 71407 :805491:805569:805187:806407

ENSG00000186866 :P0FUT2 :chr21

ENSG00000231889:TRAF3IP2-

ENSG00000183773 : AIFM3 :chr22:+:213 :46685936:46686142:46685550:466 ASl:chr6:+: 111805946: 111806064: 35035:21335056:21334413:21335280 87504 111804868:111895823 ENSG00000169919:GUSB:chr7:- ENSG00000070610 : GB A2 : chr9 : - ENSG00000136521:NDUFB5:chr3: :65435268:65435353:65432894:6543928 :35743272:35743323:35741887:357 +: 179333770: 179333837: 179322727

1 44293 : 179334770

ENSG00000169220:RGS14:chr5:+: ENSG00000106070:GRB10:chr7:-

ENSG00000172508:CARNSl:chrl 1 :+:6 176798475:176798590:176798397:1 :50686866:50686982:50660795:506 7183646:67183673:67183234:67186957 76798873 94518

ENSG00000149633:KIAA1755:chr

ENSG00000182670:TTC3:chr21:+: 20

ENSG00000213625:LEPROT:chrl:+:65 38529462:38529516:38529208:3853 :36850850:36850999:36842145:368 895544:65895731 :65891061 :65897485 2000 51939

ENSG00000143353 :LYPLAL 1 :chrl ENSGOOOOO 110455 : ACCS :chrl 1 :+:

ENSG00000054523:KIFlB:chrl:+:1038 :+:219366423:219366593:21935258 44098872:44101170:44097142:4410

6168:10386417:10384953:10394577 8:219383873 2569

ENSG00000150433:TMEM218:chr

11:- ENSGOOOOO 128973 :CLN6 :chrl 5 : -

ENSG00000163995:ABLIM2:chr4:- : 124972027: 124972198: 124971199: :68503893 :68504079:68503656:685

:7994592:7994654:7986620:8009785 124972629 10873

ENSG00000233593 :RP4-

ENSG00000129158:SERGEF:chrll:- ENSG00000099282:TSPAN15:chrl 665J23.1:chrl:- : 18021040: 18021119: 18014540: 1802204 0:+:71244896:71244971:71211446: :91297486:91297753:91255044:913 3 71255349 17039 ENSG00000145868 :FBX038 :chr5 :+: 147 ENSG00000198690:FANl:chrl5:+: ENSG00000103037:SETD6:chrl6:+

806775:147807510:147805264:1478129 31202816:31203018:31200461:3120 :58551923:58552135:58550832:585

86 6060 52304

ENSG00000198363:ASPH:chr8:- ENSG00000125675:GRIA3:chrX:+:

ENSG00000130055:GDPD2:chrX:+:696 :62594997:62595042:62593595:625 122599524:122599639:122598963:1 45612:69645706:69643232:69645901 96597 22616649 ENSG00000148660:CAMK2G:chrl0:- ENSG00000071462 :WB SCR22 xhr ENSG00000110002: VWA5A:chrl 1 : :75587846:75587879:75585105:7559722 7:+:73098096:73098253:73098003: +: 123987272: 123987387: 123986189 5 73100965 : 123988203

ENSG00000119684 :MLH3:chrl4:- ENSG00000157388:CACNAlD:chr ENSG00000136280:CCM2:chr7:+:4 :75500121:75500193:75498882:7551307 3:+:53836173:53836200:53835452: 5077851:45078025:45039962:45103 8 53837449 516

ENSG00000283352 :XXbac-

ENSG00000058404 :CAMK2B :chr7 : - ENSG00000198176:TFDPl:chrl3:+ BPGBPG55 C20.4 : chr6 : - :44272420:44272465 :44270653 :4427398 : 114291934: 114292211 : 114291015 : :58252703:58252788:58250869:582 8 114294434 56381

ENSG00000148481:MINDY3:chrl0:- ENSG00000060339:CCARl:chrl0: ENSG00000186868:MAPT:chrl7:+: : 15858833: 15858914: 15838171: 1586365 +:70516029:70516240:70515293:70 44049224:44049311 :44039836:4405 4 517050 5740

ENSG00000089094 :KDM2B :chrl2 :

ENSG00000141627:DYM:chrl8:-

ENSG00000095794:CREM:chrl0:+:354 : 122013685: 122013764: 122012498: :46735920:46736085:46690157:467

68061:35468204:35437419:35495822 122016706 83379

ENSG00000107263:RAPGEFl:chr9

ENSG00000243696:RP5-966M1.6:chr3:- ENSG00000184922:FMNLl:chrl7:

:52848224:52848379:52848087:5285089 +:43323871:43323971:43323697:43 : 134480317: 134480575: 134477536:

9 324233 134494437

ENSG00000214050:FBX016:chr8:- ENSGOOOOO 147419 : CCDC25 : chr8 : - ENSG00000142949:PTPRF:chrl:+:

:28286894:28286920:28286253:2830468 :27606011 :27606115 :27605796 :276 44078438:44078471:44075169:4407

7 10028 9288

ENSG00000074964 : ARHGEFIOL x

ENSG00000057757:PITHDl:chrl:+:241 hrl:+: 17961042: 17961057: 1795896 ENSG00000156983:BRPFl:chr3:+:

05927:24105971:24105203:24106353 1:17961329 9785907:9786192:9785585:9786691

ENSG00000078902:TOLLIP:chrll:

ENSG00000167123:CERCAM:chr9

ENSG00000102317:RBM3 :chrX:+:4843 : 1316874: 1317024: 1311639: 133069 :+: 131183482: 131183790: 13118335 4202:48434471:48433671:48434701 5 3:131185146 ENSG00000179950:PUF60:chr8:- ENSG00000078018:MAP2:chr2:+:2 ENSG00000091129:NRCAM:chr7:- : 144906482: 144906566: 144904083 : 1449 10557360:210561074:210545551:21 : 107815766: 107815802: 107807518: 11449 0561640 107816874

ENSG00000168781:PPIP5Kl:chrl5

ENSG00000141391:PRELID3A:chr

ENSG00000140264:SERF2:chrl5:+:440 18:+: 12420323 : 12420492: 12408006 :43852610:43852793:43851130:438

91141:44091305:44085281:44091816 :12421538 57064

ENSG00000132716:DCAF8:chrl:- ENSG00000136717:BINl:chr2:-

ENSG00000173436:MINOSl:chrl:+:19 : 160231074: 160231148: 160213824: : 127825738: 127825831: 127821594:

927280:19927465:19923603:19949967 160232065 127826499

ENSG00000165795:NDRG2:chrl4:- ENSG00000275832:ARHGAP23:ch ENSG00000175581:MRPL48:chrll

:21491022:21491064:21490656:2149139 rl7:+:36655173:36655196:3665406 :+:73519357:73519395:73516124:7

9 8:36656838 3536752

ENSG00000116731:PRDM2:chrl:+ ENSG00000117054: ACADMxhrl:

ENSG00000132780:NASP:chrl:+:46066 : 14095533 : 14095668: 14075982: 140 +:76199212:76199313:76198607:76

056:46066129:46056942:46067926 99572 200475

ENSG00000277363:SRCINl:chrl7: ENSG00000110888:CAPRIN2:chrl

ENSG00000134900:TPP2:chrl3:+:1033 2:-

03708:103303747:103301836:10330940 :36724458:36724482:36720549:367 :30906277:30906493:30904067:309

5 31122 07684

ENSG00000180900 : SCRIB :chr8: - ENSG00000276234:TADA2A:chrl ENSG00000112715 :VEGFA:chr6:+: : 144873835: 144873910: 144873610: 1448 7:+:35787048:35787108:35771477: 43749692:43749789:43746655:4375 74045 35797838 2277

ENSG00000124831 :LRRFIP1 :chr2:+:23 ENSG00000170899:GSTA4:chr6:- ENSGOOOOO 152726:FAM2 IB xhrlO 8647874:238647952:238617273:238657 :52852154:52852206:52850381:528 :+:47943064:47943127:47942084:4 006 58954 7943487

ENSG00000130779:CLIPl:chrl2:- ENSG00000163995:ABLIM2:chr4:-

ENSG00000112701: SENP6:chr6 :+:7635 : 122821178: 122821295: 122819252: :7985273 :7985281:7985071 :800978 0402:76350420:76344527:76357446 122825527 5 ENSG00000164815:ORC5:chr7:- ENSG00000163964:PIGX:chr3:+:l ENSG00000156875:MFSD14A:chrl : 103824570: 103824619: 103808973: 1038 96455572:196455626:196455007:19 :+: 100535169: 100535241: 10053375 28698 6457862 1:100542720

ENSG00000162426:SLC45Al:chrl: ENSG00000239922:RP11-

ENSG00000137266 : SLC22A23 :chr6 :- +:8385357:8385450:8384786:83858 71N10.1:chr3:+: 147658345: 1476584 :3415985:3416089:3324236:3456139 77 06:147657903:147724374

ENSGOOOOOH4956:DGUOK:chr2: ENSG00000248167:TRIM39-

ENSG00000173227:SYT12:chrll:+:667 +:74177711:74177859:74154179:74 RPP21:chr6:+:30313267:30313350:

97905:66798030:66797649:66802115 184251 30313175:30314208

ENSGOOOOO 116670:MAD2L2 :chrl :

ENSG00000114126:TFDP2:chr3:- ENSG00000078070 :MCCC1 :chr3 : - : 141713861: 141713983: 141712427: 1417 : 182810196: 182810333: 182804576: : 11741095: 11741495: 11740670: 117 24282 182812346 51469

ENSG00000133519 :ZDHHC8P 1 :ch r22:- ENSG00000115839:RAB3GAPl:ch

ENSG00000167889:MGAT5B:chrl7:+:7 :23736112:23736244:23735020:237 r2:+: 135925262: 135925283: 135922 4928726:74928857:74922812:74934069 41946 266:135926114 ENSG00000175066:GK5:chr3:- ENSG00000173818:ENDOV:chrl7: : 141903552: 141904635: 141901891: 1419 +:78402395:78402460:78399420:78 ENSG00000227232:WASH7P:chrl : 04770 403572 -: 17605: 17742: 17055: 17914 ENSG00000250644:RP11-

ENSG00000148468:FAM171Al:chrl0:- ENSG00000148356:LRSAMl:chr9: 295K3.1:chrll:- : 15257994: 15258109: 15256600: 1526294 +: 130253493: 130253574: 13025179 : 1768896:1769349: 1756659: 177503 2 7:130255080 2

ENSG00000067560 :RHOA:chr3 : - ENSG00000049323:LTBPl:chr2:+: ENSGOOOOO 132639: SNAP25 :chr20 : :49398360:49398499:49397815:4941286 33567904:33568030:33540336:3357 +: 10273808: 10273926: 10265420: 10 6 2433 277572

ENSG00000275778 :PRH1 -PRR4 :chrl2 :- ENSG00000144535:DIS3L2:chr2:+: ENSG00000133460:SLC2All:chr2 : 11126253:11126320:11001006: 1119961 233001181:233001429:232995429:2 2:+:24226135:24226211:24226060: 8 33028168 24226488

ENSG00000178104:PDE4DIP:chrl:- ENSG00000078549:ADCYAP1R1: ENSG00000146556:WASH2P:chr2: : 144871695: 144871881: 144868172: 1448 chr7:+:31139740:31139824:311353 +: 114353644: 114353780: 114353092 73876 64:31142850 : 114353957

ENSG00000128596:CCDC136:chr7 ENSG00000154358:OBSCN:chrl:+:

ENSG00000167703:SLC43A2:chrl7:- :+: 128449503: 128449698: 12844759 228523900:228523971:228523552:2 : 1490242: 1490254: 1489345 : 1494095 9:128450192 28524704

ENSG00000226210:ABC7- ENSG00000064270 : ATP2C2 : chrl 6 :

ENSG00000152749:GPR180:chrl3:+:95 42389800N19.1:chrl2:+:87268:873 +:84495593:84495735:84495418:84

271403:95271584:95264644:95271721 67:78939:87556 497219

ENSG00000150756:FAM173B:chr5

ENSG00000167232:ZNF91:chrl9:- ENSG00000131375 : CAPN7 : chr3 : +: :23556543:23556639:23545527:2355743 15282959:15283095:15282360:1528 : 10235322: 10235373: 10227759: 102 9 3684 36589

ENSG00000078487 :ZCWPW 1 :chr7 ENSGOOOOO 189212 :DPY19L2P1 :ch

ENSG00000197971 :MBP:chrl 8 :- r7> :74697159:74697166:74696850:7470083 : 100000138: 100000199:99998959:1 :35142528:35142642:35131558:351 2 00001316 44255

ENSG00000168785:TSPAN5:chr4:- ENSG00000137817:PARP6:chrl5:- ENSGOOOOO 145087 : STXBP5L :chr3

:99407888:99408035:99403326:9942882 :72541585:72541655:72535040:725 :+: 121001112: 121001184: 12099880

8 42360 3:121037321

ENSG00000228315:GUSBPll:chr2 ENSG00000157890:MEGFll:chrl5

2:-

ENSG00000090661:CERS4:chrl9:+:827 :24036305:24037704:24002187:240 :66201371:66201473:66198479:662

5589:8275746:8274378:8315959 47615 04419

ENSG00000171103:TRMT61B:chr2:- ENSGOOOOO 138162 : TACC2 : chrl 0 : ENSGOOOOO 107186 :MPDZ :chr9 : -

:29087882:29087985:29075365:2909244 +: 123972856: 123972892: 12397122 : 13136710: 13136802: 13136181: 131

4 3:123974905 37955

ENSG00000108946:PRKARlA:chrl7:+: ENSG00000066651 : TRMT 11 : chr6 : ENSG00000085721:RRN3:chrl6:- 66511127:66511260:66508283 :6651153 +: 126327987: 126328100: 12632075 : 15180221:15180311:15180115: 151 4 9:126329537 85171

ENSG00000106078:COBL:chr7:- ENSG00000064787:BCASl:chr20:- ENSGOOOOO 159063 : ALG8 :chrl 1 : - :51111079:51111389:51085265 :5115286 :52591927:52591969:52574036:526 :77849755:77849813:77838482:778 2 01825 50539

ENSG00000175785:PRIMAl:chrl4

ENSG00000105221 : AKT2 :chrl 9: - ENSG00000085982 :USP40 :chr2 : - :40771128:40771258:40762961:4079108 :94192181:94192352:94187892:942 :234399677:234399717:234398129: 7 03586 234399812 ENSG00000008128:CDKllA:chrl:

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000168646:AXIN2:chrl7:- : 131193510: 131193678: 131191521: 1311 : 1643702: 1643839: 1641079: 164778 :63532986:63533181:63532671:635 99243 4 33441

ENSG00000124313 :IQSEC2:chrX:- ENSG00000163995:ABLIM2:chr4:-

ENSG00000186812 :ZNF397 xhrl 8 :+: 32 :53308745:53308841:53296246:533 :8034374:8034407:8031503:803787 834195:32834366:32823257:32837891 10677 5

ENSG00000118454: ANKRD13C:ch

ENSG00000088387 :DOCK9 xhrl 3 :- ENSG00000011198 : ABHD5 :chr3 :+ rl>

:99498177:99498245:99489863:9950084 :43759257:43759349:43756550:437 :70740402:70740501:70728530:707

5 59934 42447

ENSG00000104613:INTS10:chr8:+: ENSG00000160310:PRMT2:chr21:

ENSG00000105953:OGDH:chr7:+:4469 19677889:19678029:19677187:1967 +:48056350:48056459:48055675:48

5916:44695961:44687358:44706334 9949 056807

ENSG00000188735:TMEM120B:ch ENSG00000165914:TTC7B:chrl4:-

ENSG00000198520:Clorf228:chrl:+:45 rl2:+: 122208812: 122208878: 12219 :91069596:91069647:91059970:910

163734:45163901:45162842:45166594 9644:122211326 77085

ENSG00000100462:PRMT5:chrl4:- ENSG00000167130 :DOLPP 1 :chr9 : ENSG00000099290:WASHC2A:chr

:23397705:23397824:23397420:2339846 +: 131847301: 131847386: 13184704 10:+:51851921:51851993:51851278

0 7:131847796 :51853027

ENSG00000104812:GYSl:chrl9:- ENSG00000072195 : SPEG:chr2 :+:2 ENSG00000163681:SLMAP:chr3:+:

:49485976:49486094:49485632:4948871 20308746:220308781:220307872:22 57911571:57911661:57908750:5791

7 0309374 3022

ENSG00000141837:CACNAlA:chr

ENSG00000206145 :P2RX6P : chr22 : - 19:- ENSG00000204084 :INPP5B xhrl :- :21396631:21396703:21389725:2139843 : 13338244: 13338341: 13335586: 133 :38409467:38409565:38409341:384 7 40895 11427

ENSG00000185046:ANKSlB:chrl2

ENSG00000059915:PSD:chrl0:- ENSG00000107902:LHPP:chrl0:+: : 104175773: 104175876: 104174986: 1041 126186604:126186697:126177144:1 :99201621:99201693:99194903:994 76141 26301832 46934

ENSG00000072071 : ADGRL1 xhrl 9:- ENSG00000138621:PPCDC:chrl5:

ENSG00000185737:NRG3:chrl0:+:8462 : 14277827 : 14277842: 14274218 : 142 +:75336726:75336855:75315967:75

5166:84625193:84498406:84711224 81493 340893

ENSG00000169045:HNRNPHl:chr

ENSG00000082641 :NFE2L1 :chrl7: 5:-

ENSG00000101158 :NELFCD :chr20 :+: 5 +:46134393:46134483:46133960:46 : 179046269: 179046408: 179045324: 7568678:57568730:57568167:57569164 134705 179047892 ENSG00000147799:ARHGAP39:chr8:- ENSG00000133872 : S ARAF : chr8 : - ENSG00000099290:WASHC2A:chr : 145763104: 145763197: 145759586: 1457 :29931392:29931571:29927575:299 10:+:51859737:51859824:51857562 70632 40362 :51863801

ENSG00000119650:IFT43:chrl4:+: ENSG00000080823:MOK:chrl4:-

ENSG00000143774:GUKl:chrl:+:22832 76524984:76525017:76488737:7654 : 102732159: 102732249: 102718332: 8824:228329208:228328064:228333211 8637 102749814 ENSG00000242808:SOX2- ENSG00000143393:PI4KB:chrl:- ENSG00000104365:IKBKB:chr8:+: OT:chr3:+: 181432972: 181433080: 18132 : 151297220: 151297393: 151288985: 42177102:42177164:42176939:4217 8717:181457356 151298647 8252

ENSG00000235194:PPPlR3E:chrl4:- ENSG00000053524:MCF2L2:chr3:-

:23769966:23770073:23768750:2377060 : 182948921: 182949000: 182948805: ENSG00000103202:NME4:chrl6:+:

6 182994659 448207:448394:447313:448989

ENSG00000050820:BCARl:chrl6:- ENSG00000131437:KIF3A:chr5:- ENSG00000154358:OBSCN:chrl:+:

:75271080:75271242:75269884:7527636 :132042142:132042151:132039311: 228486959:228487223:228486418:2

7 132046650 28487582

ENSG00000114859:CLCN2:chr3:- ENSG00000120963:ZNF706:chr8:-

ENSG00000173947:PIFO:chrl:+:111890 : 184071449: 184071583: 184071210: : 102214560: 102214675: 102213971: 295:111890394:111889671:111891137 184071888 102217662 ENSG00000062598 :ELM02 : chr20 : - ENSG00000140474:ULK3:chrl5:- ENSG00000110514:MADD:chrll:+ :45027335:45027410:45022728:4503518 :75134875:75135015:75134761:751 :47314093:47314147:47312367:473 6 35344 17046

ENSG00000080823:MOK:chrl4:- ENSG00000074964 : ARHGEFIOL :c ENSG00000134698:AG04:chrl:+:3 : 102698871 : 102699008: 102695994: 1027 hrl:+: 17939552: 17939669: 1793008 6298037:36298171:36297786:36299 00024 6:17942588 590

ENSG00000107862:GBFl:chrl0:+:1041 ENSG00000213742 :ZNF337- ENSG00000076984:MAP2K7:chrl9

12214:104112275:104111708:10411335 ASl:chr20:+:25655532:25655714:2 :+:7970692:7970740:7968953:7974

6 5654643:25657571 639 ENSG00000135597 :REPS 1 : chr6 : - ENSG00000230124:ACBD6:chrl:- ENSG00000117143 :UAP1 xhrl :+: 1 : 139265634: 139265759: 139262626: 1392 : 180464595: 180464660: 180399397: 62562524: 162562572: 162560301 : 16 66355 180471179 2567581

ENSG00000110446: SLC15 A3 xhrl

ENSG00000124596:OARDl:chr6:- ENSG00000169398:PTK2:chr8:- 1:-

:41037814:41037873:41035176:4103887 : 141779673: 141779691: 141774389: :60708593 :60708762:60707110:607

0 141799572 09506

ENSG00000120685:PROSERl:chrl ENSG00000214941:ZSWIM7:chrl7

ENSG00000058866 :DGKG:chr3 : - 3:- : 185978227: 185978302: 185975728: 1859 :39596462:39596549:39591681:395 : 15880892: 15881227: 15880406: 158 79487 98609 81357

ENSG00000214331:RP11- ENSG00000108395:TRIM37:chrl7:

252A24.2:chrl6:-

ENSG00000196405 :EVL :chrl4 :+: 10060 :74371372:74371521:74370604:743 :57181653:57181755:57168701:571 4076:100604139:100603981:100607516 72342 83801 ENSG00000151532:VTIlA:chrl0:+:114 ENSG00000178053:MLFl:chr3:+:l ENSG00000052126:PLEKHA5:chrl 293288: 114293309: 114286923 : 1142980 58310222:158310370:158289180:15 2:+: 19499927: 19500116: 19498822: 04 8314650 19501332

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000104529:EEFlD:chr8:- ENSG00000059588:TARBPl:chrl:- : 131186675: 131186774: 131184858: 1312 : 144672777: 144672908: 144672251 : :234534127:234534299:234529583: 06235 144674816 234536926

ENSG00000241370:RPP21:chr6:+:3 ENSG00000072518:MARK2:chrl 1 :

ENSG00000049759 :NEDD4L :chrl 8 :+: 5 0313243:30313350:30313175:30314 +:63675731:63675776:63672515:63 6010137:56010335:56001124:56016768 208 676348

ENSG00000280670:CCDC163:chrl

ENSG00000050767:COL23Al:chr5:- ENSG00000117697:NSLl:chrl:- : 177683866: 177683929: 177683398: 1776 :45962227:45962295:45961217:459 :212912875:212912943:212912028: 84523 65016 212939530

ENSG00000165029:ABCAl:chr9:- ENSG00000183077:AFMID:chrl7:

ENSG00000134330:IAHl:chr2:+:96161 : 107549153: 107549257: 107548671: +:76198783:76198832:76187141:76

15:9616168:9614776:9621414 107550200 202026

ENSG00000121753:ADGRB2:chrl:

ENSG00000186567 :CEACAM19 :chrl 9: ENSGOOOOO 162971 :TYW5 :chr2 :- +:45182124:45182208:45176236:451835 :32208438:32208603:32207818:322 :200808487:200808557:200804856: 59 10248 200813059

ENSG00000161298:ZNF382:chrl9:

ENSG00000160796 :NBEAL2:chr3 :+:47 ENSG00000023191 :RNH1 xhrl 1 :- +:37101551:37101644:37098524:37 046461 :47046586:47046080:47046670 :504823:504996:502181:507112 117031

ENSG00000204536:CCHCRl:chr6:

ENSG00000206503 :HLA- ENSG00000131389:SLC6A6:chr3:+

A:chr6:+:29912839:29912868:29912174: : 14509595: 14509720: 14509464: 145 :31111038:31111190:31110911:311

29913010 13712 12463

ENSG00000146067:FAM193B:chr5

ENSG00000033100:CHPF2:chr7:+:1509 ENSG00000144935 :TRPC1 :chr3 :+:

33493:150933676:150932698:15093445 142509860:142510000:142503882:1 : 176958282: 176958522: 176952206:

9 42521010 176963358

ENSG00000242686:RP11- ENSG00000120088:CRHRl:chrl7: ENSG00000168894:RNF181:chr2:+

1191J2.2:chr4:- +:43898720:43898806:43893948:43 :85823944:85824054:85823772:858

:647853:648002:647760:648870 906580 24226

ENSG00000137965:IFI44:chrl:+:79

ENSG00000075292:ZNF638:chr2:+:716 ENSG00000182903:ZNF721:chr4:- 126238:79126339:79125168:791283

49943:71651168:71645769:71658456 :466363:466490:438221:492844 88

ENSG00000126746:ZNF384:chrl2:

ENSG00000071054:MAP4K4:chr2:

ENSG00000138029:HADHB:chr2:+:264 :6781515:6781698:6780004:678238 +: 102480282: 102480513 : 102472600

77114:26477186:26467858:26486247 1 :102481391

ENSG00000169992:NLGN2:chrl7: ENSG00000168591:TMUB2:chrl7:

ENSG00000219626:FAM228B:chr2:+:2 +:7311330:7312031:7308929:73154 +:42265043 :42265111 :42264477:42

4357988:24358057:24318099:24387067 75 265274

ENSG00000196118:CCDC189:chrl6:- ENSG00000116539: ASHlLxhrl:- ENSG00000141552:ANAPCll:chrl

:30770332:30770568:30768975:3077066 : 155385534: 155385714: 155365344: 7:+:79851427:79851490:79849709:

2 155408117 79852342

ENSG00000102309:PIN4:chrX:+:7 ENSG00000149927:DOC2A:chrl6:-

ENSG00000178078:STAP2:chrl9:- 1406083:71406384:71401678:71416 :30022223:30022310:30021556:300

:4324451:4324661:4324194:4325212 634 22650 ENSG00000126214:KLCl:chrl4:+: ENSG00000242588:RP11-

ENSG00000204580:DDRl:chr6:+:30853 104153417:104153548:104145882:1 274B21.14:chr7:+: 128248171: 12824

401:30853457:30848902:30856464 04166991 8267:128232071:128255913 ENSG00000160828:STAG3L2:chr7

ENSG00000126698:DNAJC8:chrl:- ENSG00000175029:CTBP2:chrl0:- :28556641:28556763:28555534:2855943 : 126727565 : 126727724: 126692061 : :74301136:74301260:74300638:743 1 126848887 03803

ENSG00000089157:RPLP0:chrl2:- ENSG00000025423:HSD17B6:chrl ENSG00000204580 :DDR1 :chr6 :+: 3 : 120636356: 120636434: 120635265: 1206 2:+:57156987:57157198:57146365: 0852314:30852487:30848902:30856 36656 57167617 464

ENSG00000198932:GPRASPl:chr ENSG00000159840:ZYX:chr7:+:14

ENSG00000078018:MAP2:chr2:+:21037 X:+: 101907102: 101907193: 101906 3084854:143084880:143080415:143

2315:210372365:210289000:210444759 523:101907758 085311

ENSG00000130958:SLC35D2:chr9:

ENSG00000168385:SEPT2:chr2:+:2

ENSG00000123124:WWPl:chr8:+:8741 :99122435 :99122503:99086451:991 42263630:242263656:242255397:24

0800:87410867:87393858:87414247 26745 2263823

ENSG00000017260:ATP2Cl:chr3:+ ENSG00000101294:HM13:chr20:+:

ENSG00000173436:MINOSl:chrl:+:19 : 130613574: 130613619: 130613181: 30155880:30156027:30154098:3015 948593 :19948641 : 19923603 :19952880 130649259 6922 ENSG00000162755:KLHDC9:chrl:+:16 ENSG00000183111 : ARHGEF37: ch 1069135:161069295:161068852:161069 ENSG00000162004:CCDC78:chrl6 r5:+: 148977321: 148977518: 148961 850 :-:773856:773936:773161:774105 187:148980670

ENSG00000110888:CAPRIN2:chrl2:- ENSG00000117859:OSBPL9:chrl: ENSG00000163138:PACRGL :chr4 :

:30906277:30906493:30904067:3090761 +:52205814:52205883:52179751:52 +:20726430:20726511:20715162:20

4 211207 728907

ENSG00000079819:EPB41L2:chr6:

ENSG00000077157:PPPlR12B:chrl:+:2 ENSG00000121897:LIAS:chr4:+:39

02544129:202544310:202538325:20254 : 131201283: 131201346: 131186774: 466904:39466962:39465225:394691

9601 131206235 37

ENSG00000114988:LMAN2L:chr2:

ENSG00000010361:FUZ:chrl9:- ENSG00000108387:SEPT4:chrl7:-

:50315703:50315993:50315592:5031638 :56604292:56604339:56603674:566 :97399255:97399338:97377762:974

9 06475 00145

ENSG00000142694:EVAlB:chrl:- ENSG00000170919:TPT1- ENSG00000154099:DNAAFl:chrl6

:36788571:36788668:36788326:3678905 ASl:chrl3:+:45957225:45957370:4 :+:84195795:84195821:84193401:8

9 5954136:45963869 4199388

ENSG00000164669:INTS4Pl:chr7: ENSG00000005243 :COPZ2 :chrl7 : -

ENSG00000166532:RIMKLB:chrl2:+:8 +:64691918:64692314:64670191:64 :46110576:46110668:46106542:461

932630:8932708:8930398:8933170 693442 11228

ENSG00000254901:BORCS8:chrl9

ENSG00000196295:AC005154.6:chr7:- ENSG00000197008 :ZNF 138 : chr7 :+

:30591715:30591795:30590397:3060108 : 19297701: 19297814: 19293492: 193 :64291317:64291454:64276031:642

1 02889 91828

ENSG00000273000:KB-

ENSG00000149294:NCAM1 xhrl 1 :+: 11 1572G7.2:chr22:- ENSG00000198794:SCAMP5:chrl5 3143654:113144470:113142598:113145 :24025911:24026054:24002187:240 :+:75308933:75309090:75305146:7 988 29024 5310210

ENSG00000095637:SORBSl:chrl0

ENSG00000092871 :RFFL :chrl7: -

ENSG00000154914:USP43:chrl7:+:957 :97131082:97131184:97127456:971 :33348389:33348800:33344625:333

8207:9578300:9570068:9580062 35729 53392

ENSGOOOOO 186625 :KATNA 1 : chr6 :

ENSG00000148341:SH3GLB2:chr9:- ENSG00000176783 :RUFY1 :chr5 :+: : 131771731:131771746: 131771625: 1317 : 149922729: 149922888: 149919486: 179013331:179013476:179012866:1 72049 149924403 79016546

ENSG00000082397:EPB41L3:chrl8

ENSG00000036257:CUL3:chr2:-

ENSG00000131797:CLUHP3:chrl6:+:3 :225422375:225422573:225400358: :5400967:5401042:5397425:540677

1716992:31717113:31716793:31717210 225449660 5

ENSG00000171045:TSNAREl:chr8

ENSG00000135486:HNRNPAl:chrl2:+: ENSG00000113845:TIMMDCl:chr

54675578:54675725:54675286:5467587 : 143427103: 143427253: 143425833: 3 :+: 119219541: 119219707: 1192177

3 143435997 74:119232487

ENSG00000119688:ABCD4:chrl4:- ENSG00000084207:GSTP1 xhrl 1 :+ ENSG00000196263 :ZNF471 xhrl 9:

:74766250:74766378:74764772:7476957 :67351604:67351640:67351315:673 +:57027643 :57027770:57022973 :57

7 52155 029850 ENSG00000143429:AC027612.6:ch

ENSG00000170017:ALCAM:chr3:+:105 r2:- ENSG00000105397:TYK2:chrl9:-

270987:105271026:105269103:1052713 :91842945:91843023:91831379:918 : 10464203 : 10464322: 10463227: 104

11 43393 64717

ENSG00000144647 :POMGNT2 : chr3 : - ENSG00000168301 :KCTD6:chr3 :+: ENSGOOOOO 148290 : SURF 1 : chr9 : - :43131979:43132101 :43123028:4314732 58479879:58480135:58477896:5848 : 136223123: 136223175: 136221596:

7 4439 136223275

ENSG00000197989:SNHG12:chrl:- ENSG00000204642:HLA-

ENSG00000004487 :KDM1 Axhrl :+:233 :28907622:28907741:28907158:289 F:chr6:+:29693787:29693820:29693 92552:23392564:23385660:23395031 08101 340:29694659

ENSG00000215908:CROCCP2:chrl

ENSG00000187531 : SIRT7 : chrl 7 : - ENSG00000067066:SP100:chr2:+:2 :79871082:79871169:79870490:7987164 31314886:231314970:231313865:23 : 16959589: 16959841: 16958866: 169 9 1325976 61521

ENSG00000080822:CLDND1 :chr3 :

ENSG00000101040:ZMYND8:chr20:- ENSG00000089472:HEPH:chrX:+:6

:45841286:45841370:45839542:4584890 :98240496:98240540:98240281:982 5474876:65474983 :65428088:65478

8 41385 681

ENSG00000160226 : C21 orf2 : chr21 : ENSG00000138623:SEMA7A:chrl

ENSG00000122490:PQLCl:chrl8:- 5:-

:77679183:77679400:77664183:7770332 :45753943:45755687:45753145:457 :74710608:74710650:74710310:747

8 57531 11141

ENSG00000231584:FAHD2CP:chr ENSG00000100379:KCTD17:chr22

ENSG00000133816:MICAL2:chrll:+:l 2:+:96685285:96685448:96681073: :+:37456862:37456962:37455478:3 2277189:12277297:12261132:12278331 96686872 7458564 ENSG00000159445:THEM4:chrl:- ENSGOOOOO 111596 : CN0T2 : chrl 2 : ENSG00000142875:PRKACB:chrl: : 151862458: 151862690: 151861849: 1518 +:70726546:70726626:70713144:70 +:84639011:84639035:84630696:84 67483 729217 644859

ENSG00000091129:NRCAM:chr7:- ENSG00000206149:HERC2P9:chrl ENSG00000062194:GPBPl:chr5:+: : 107815766: 107815802: 107808847: 1078 5:+:28863364:28863524:28857319: 56532939:56532999:56531859:5654 16874 28863669 2126

ENSG00000151881 :TMEM267 :chr ENSG00000122203:KIAA1191:chr

ENSG00000139613:SMARCC2:chrl2:- 5:- 5:-

:56558086:56558152:56557549:5655843 :43453759:43454145:43446659:434 : 175782573: 175782752: 175779751:

1 76215 175788604

ENSG00000001461 :NIPAL3 :chrl :+ ENSG00000165995:CACNB2:chrl0

ENSG00000073417:PDE8A:chrl5:+:856 :24745780:24746130:24742394 :247 :+: 18803164: 18803298: 18795476:1 32568:85632647:85626875:85641178 66661 8807264 ENSG00000198300 :PEG3 :chrl 9: - ENSG00000068354:TBClD25:chrX ENSG00000117569:PTBP2:chrl:+: : 57337755:57337831:57335795:5734465 :+:48399720:48399830:48398308:4 97271974:97272008:97270495:9727 7 8417284 2421

ENSG00000108387:SEPT4:chrl7:- ENSG00000180376:CCDC66:chr3: ENSGOOOOO 131398 :KCNC3 :chrl 9 :-

:56604127:56604339:56603674:5660647 +:56599161:56599232:56598153:56 :50823479:50823606:50819348:508

5 600621 23849

ENSG00000166839:ANKDDlA:chrl5:+ ENSG00000165973 :NELLl:chrl 1 :+ ENSG00000197603:C5orf42:chr5:- :65236848:65236944:65235778:6523962 :21555919:21556060:21392494:215 :37157414:37157522:37154095:371 3 81734 57771

ENSGOOOOO 131778 : CHD 1L : chrl : +: ENSG00000136699:SMPD4:chr2:-

ENSG00000129103:SUMF2:chr7:+:561 146724277:146724390:146714480:1 : 130914157: 130914386: 130913708:

41866:56141911:56140804:56142278 46726524 130921946

ENSG00000109339:MAPK10:chr4:

ENSG00000071054:MAP4K4:chr2:+:10 ENSG00000183077:AFMID:chrl7:

2487955:102488147:102486877:102490 :87019676:87020438:86989108:870 +:76201683:76201819:76201599:76

108 22204 202026

ENSG00000140859:KIFC3:chrl6:- ENSG00000097033 : SH3 GLB 1 :chrl ENSG00000105376:ICAM5:chrl9:+

:57793036:57793065:57792821:5779363 :+:87194085:87194124:87190088:8 : 10401747: 10401992: 10400801: 104

9 7195770 02164

ENSG00000105186:ANKRD27:chr

ENSG00000119929:CUTC:chrl0:+: 19:-

ENSG00000131626:PPFIAl:chrll:+:70 101510125:101510153:101507147:1 :33106563:33106686:33098738:331 211478:70211541:70208594:70218317 01514285 08494 ENSG00000129675:ARHGEF6:chrX:- ENSG00000162065:TBClD24:chrl ENSG00000064655:EYA2:chr20:+: : 135761693: 135761819: 135758876: 1357 6:+:2548242:2548397:2547114:254 45702796:45702974:45644936:4571 62889 9357 7877

ENSG00000110076 :NRXN2 :chrl 1 :- ENSG00000078674:PCMl:chr8:+:l ENSG00000178188:SH2Bl:chrl6:+ :64393934:64394024:64387844:6439787 7782221 : 17782289: 17780697: 17794 :28883100:28883304:28880704:288 3 642 83510 ENSG00000169241:SLC50Al:chrl: ENSG00000167107:ACSF2:chrl7:+

ENSG00000168297:PXK:chr3:+:584091 +: 155110036: 155110198: 15510885 :48549788:48549940:48548496:485 87:58409221:58398690:58410478 2:155110454 51025 ENSG00000115307:AUPl:chr2:- ENSG00000005243:COPZ2:chrl7:- ENSG00000204209:DAXX:chr6:- :74755374:74755448:74755133:7475587 :46105041:46105155:46103841:461 :33287787:33288001:33287631:332

7 06490 89495

ENSG00000167114 : SLC27 A4 : chr9 : ENSG00000198369:SPRED2:chr2:-

ENSG00000097033 : SH3 GLB 1 xhrl :+: 8 +: 131112590: 131112660: 13111098 :65561738:65561907:65559185:655 7194085:87194124:87190088:87200284 2:131114916 71852 ENSG00000103121:CMC2:chrl6:- ENSG00000106868:SUSDl:chr9:- ENSG00000101639:CEP192:chrl8: :81014374:81014484:81010076:8104033 : 114814678: 114814718: 114804240: +: 13103873: 13103966: 13103587: 13

8 114820707 104982

ENSG00000107147:KCNTl:chr9:+:138 ENSG00000102606:ARHGEF7:chr

670269:138670341:138669356:1386705 13:+: 111862218: 111862349: 111806 ENSG00000137033:IL33:chr9:+:62

33 338:111870025 51139:6251265:6241785:6252865

ENSG00000206503 :HLA- ENSG00000188566:NDORl:chr9:+ ENSG00000118473 :SGIP1 xhrl :+:6 A:chr6:+:29912276:29912411:29912174: : 140108418: 140108520: 140108330: 7147551:67148052:67145435:67154 29912835 140108655 830

ENSG00000135486:HNRNPAl:chrl2:+: ENSG00000100425:BRDl:chr22:- ENSG00000143537:ADAM15:chrl:

54676862:54677018:54676658:5467759 :50181037:50181535:50171461:501 +: 155033893: 155033965: 155033308

5 87681 :155034379

ENSG00000110321 :EIF4G2:chrl 1 :- ENSG00000108064:TFAM:chrl0:+:

ENSG00000140416:TPMl:chrl5:+:6335 : 10823207: 10823321: 10822634: 108 60150524:60150620:60148579:6015 6262:63356389:63354844:63358094 23595 4117 ENSG00000114062 :UBE3 A:chrl 5 : - ENSG00000135090:TAOK3:chrl2:- ENSG00000171634:BPTF:chrl7:+: :25652213:25652375:25650649:2565376 : 118673599: 118674498: 118673476: 65959448:65959622:65955991:6596

6 118675877 0327

ENSG00000070061:IKBKAP:chr9:- ENSG00000153113:CAST:chr5:+:9

ENSG00000167081 :PBX3 :chr9 :+: 12872 : 111681090: 111681181:111679950: 6064856:96064913:96063234:96065 4380:128724493:128723128:128725290 111685121 315

ENSG00000198208 :RPS6KL 1 xhrl 4:- ENSG00000125676 :THOC2 xhrX:-

ENSG00000168005 :C1 lorf84:chrl 1 :+:6 :75385215:75385308:75378083:753 : 122757494: 122757560: 122757134: 3585998:63586124:63585837:63586273 86547 122757637

ENSG00000276234:TADA2A:chrl ENSG00000077522 : ACTN2 xhrl :+:

ENSG00000168096:ANKS3:chrl6:- 7:+:35818625:35818689:35804870: 236897732:236897818:236894614:2 :4781512:4781580:4780152:4784156 35825534 36900421

ENSGOOOOO 168970 :JMJD7- ENSG00000145526:CDH18:chr5:-

ENSG00000059145:UNKL:chrl6:- PLA2G4B:chrl5:+:42134751:42134 : 19878140: 19878199: 19839351: 199 : 1463846: 1464056: 1453345: 1464615 789:42134474:42136668 81168 ENSG00000088298:EDEM2:chr20:- ENSG00000163482:STK36:chr2:+: ENSG00000091129:NRCAM:chr7:- :33722540:33722752:33714178:3372568 219553113:219553216:219549951:2 : 107866088: 107866145: 107864280: 2 19553419 107866651

ENSG00000176454:LPCAT4:chrl5:

ENSG00000155329:ZCCHC10:chr5:- ENSG00000214548:MEG3:chrl4:+: : 132335823: 132335865: 132334542: 1323 101302075:101302216:101297871:1 :34653600:34653733:34652410:346 62188 01302503 54396

ENSG00000126768:TIMM17B:chr

ENSG00000146112:PPPlR18:chr6:- X:- ENSG00000186868:MAPT:chrl7:+:

:30652184:30652321:30647166:3065489 :48754041:48754141:48751508:487 44049224:44049311 :44039836:4406

0 55006 4405

ENSG00000141837:CACNAlA:chr

ENSG00000077522:ACTN2:chrl:+:236 19:- ENSG00000081377:CDC14B:chr9:-

898934:236899020:236897818:2369004 : 13338244: 13338341: 13335586: 133 :99277930:99278074:99272071:992

21 42523 84787

ENSG00000163608:NEPRO:chr3:- ENSG00000171817:ZNF540:chrl9:

ENSG00000166411:IDH3A:chrl5:+:784 : 112729489: 112729551 : 112727277: +:38091907:38092006:38090653:38 47554:78447617:78441772:78449914 112729891 102413 ENSG00000145247 :OCIAD2 : chr4 : - ENSG00000028203:VEZT:chrl2:+: ENSG00000147041:SYTL5:chrX:+: :48899820:48899874:48887582:4890650 95650325:95650398:95645847:9565 37984550:37984759:37981468:3798 0 0925 5840

ENSG00000103174:NAGPA:chrl6:

ENSG00000139725:RHOF:chrl2:-

ENSG00000157734:SNX22:chrl5:+:644 :5077278:5077380:5077199:507784 : 122231057: 122231145: 122219098: 45443 : 64445585:64444941:64445850 6 122237752 ENSG00000116641 :DOCK7 :chrl ENSG00000111011:RSRC2:chrl2:- ENSG00000163618:CADPS:chr3:- :63010617:63010710:63009416:6301840 : 123005050: 123005128: 123003576: :62516328:62516487:62503925:625 2 123005931 18545

ENSG00000169762:TAPTl:chr4:- ENSG00000176293:ZNF135:chrl9: ENSG00000168970: MJD7- : 16204084: 16204203 : 16193146: 1622788 +:58571336:58571403:58570678:58 PLA2G4B:chrl5:+:42135323:42135 1 572947 421:42134789:42135873

ENSG00000137877:SPTBN5:chrl5:

ENSG00000149743 :TRPT1 xhrl 1 :-

ENSG00000005884:ITGA3:chrl7:+:481 :63991571:63991634:63991439:639 :42144831:42144933:42143567:421

65588:48165730:48165233:48166473 91756 45021

ENSG00000074370 : ATP2 A3 : chrl 7 :

ENSG00000169231 :THBS3 :chrl :- ENSG00000108848:LUC7L3:chrl7: : 155165777: 155165917: 155165690: 1551 +:48826579:48826705:48825777:48 :3831520:3831621:3828735:383195 66831 827861 6

ENSG00000224924 :LINC00320 :chr

ENSG00000179915:NRXNl:chr2:- 21:- ENSG00000119048:UBE2B:chr5:+:

:50172250:50172344:50170929:5020110 :22150960:22151114:22150865:221 133712359:133712385:133710154:1

5 53666 33725915

ENSG00000077522:ACTN2:chrl:+: ENSG00000145016:RUBCN:chr3:-

ENSG00000168958:MFF:chr2:+:228195 236890977:236891056:236889320:2 : 197426057: 197426102: 197423920:

310:228195562:228190143:228197134 36894532 197427483

ENSG00000068831:RASGRP2:chrl

ENSG00000163618:CADPS:chr3:- ENSG00000159596:TMEM69:chrl: 1:- :62479319:62479340:62478121:6248483 +:46156645:46156782:46153947:46 :64507839:64507921:64507635:645

6 158875 08419

ENSG00000258461:RP11- ENSG00000123636:BAZ2B:chr2:- ENSG00000136828:RALGPSl:chr9

164J13.1:chrl5:+:42700408:42700522:4 : 160193452: 160193588: 160189197: :+: 129796709: 129796793 : 12974002

2695975:42701500 160194077 4:129815125

ENSG00000156973 :PDE6D :chr2 :- ENSG00000079156 :0SBPL6 :chr2 : ENSG00000165055:METTL2B:chr

:232601896:232602002:232597743:2326 +:179236852: 179236960: 17922654 7:+: 128118002: 128118046: 1281172

02722 2:179238616 27:128119211

ENSG00000214548:MEG3:chrl4:+:101 ENSG00000145868:FBX038:chr5: ENSG00000122786:CALDl:chr7:+:

300968:101301088:101297871:1013025 +: 147806775 : 147807285 : 14780526 134647570:134647685:134645379:1

03 4:147812986 34650056

ENSG00000270249:RP11-

ENSG00000119403 :PHF 19 :chr9 :- 514P8.7:chr7:-

ENSG00000153707:PTPRD:chr9:- : 123624195: 123624283: 123623452: : 102207028: 102207183: 102182109: :8523512:8523524:8521546:8524924 123624865 102207443 ENSG00000149182 : ARFGAP2 :chrl 1 : - ENSG00000115109:EPB41L5:chr2: ENSG00000159761:C16orf86:chrl6 :47197401:47197474:47193351:4719806 +: 120925455 : 120925583 : 12092508 :+:67701129:67701428:67700975:6 6 3:120932416 7701780

ENSG00000006634:DBF4:chr7:+:8 ENSG00000126777:KTNl:chrl4:+:

ENSG00000182272 :B4GALNT4:chrl 1 : 7533606:87533731:87530193:87536 56068474:56068598:56047072:5607 +:380670:380951:380445:381668 502 8736 ENSGOOOOO 198157:HMGN5 xhrX: - ENSG00000179314:WSCDl:chrl7: ENSGOOOOOO 11347: SYT7 :chrl 1 : - :80374228:80374258:80373984:8037703 +:6014090:6014255:5998543:60213 :61314648:61314780:61300596:613 3 07 18855

ENSG00000226174 : TEX22 :chrl 4 : + ENSG00000205571 : SMN2 :chr5 :+:6

ENSG00000124275:MTRR:chr5:+:7873 : 105911754: 105911848: 105905076: 9372347:69372401:69366578:69372

485:7873625:7871036:7875370 105916394 845

ENSG00000095637:SORBSl:chrl0

ENSG00000075151 :EIF4G3 xhrl :- ENSG00000145819:ARHGAP26:ch

:21324093:21324126:21307720:2132920 :97131082:97131184:97127456:971 r5 :+: 142586762: 142586873 : 142526

5 41441 946:142593561

ENSG00000214941:ZSWIM7:chrl7:- ENSG00000074657:ZNF532:chrl8: ENSG00000065559:MAP2K4:chrl7 : 15881113: 15881227: 15880406: 1588135 +:56598877:56598987:56587865:56 :+: 11984672: 11984847 : 11958308: 1 7 601664 1998891

ENSGOOOOO 183576: SETD3 :chrl4 : - ENSG00000139624:CERS5:chrl2:- ENSG00000066084:DIP2B:chrl2:+:

:99880212:99880271:99872927:9992461 :50529215:50529435:50528485:505 51086731:51086796:51080465:5108

5 29514 9049

ENSG00000062598:ELM02:chr20:

ENSG00000119231 :SENP5:chr3 :+: 1966 ENSG00000198909:MAP3K3:chrl7 54666: 196654750: 196650422: 19665650 :45027335:45027410:45017859:450 :+:61769601:61769779:61769222:6 3 35186 1770908

ENSG00000162813:BPNTl:chrl:- ENSGOOOOO 160741 : CRTC2 : chrl : - ENSG00000105426:PTPRS:chrl9:- :220253068:220253196:220247413:2202 : 153923735: 153924142: 153921860: :5231320:5231626:5222231:523892 63027 153924493 9 ENSG00000169783:LING01:chrl5:

ENSG00000060971 : ACAA1 :chr3 ENSG00000138031:ADCY3:chr2:- :38167652:38167832:38167372:3816800 :78027333:78027395:77983243:780 :25043252:25043320:25042983 :250 0 88280 43592

ENSG00000169045 :HNRNPH1 xhr

ENSG00000161395:PGAP3:chrl7:- 5:- ENSG00000072163:LIMS2:chr2:- :37830869:37830932:37829119:3784084 : 179045145: 179045324: 179044912: : 128431251:128431317: 128415136: 9 179047892 128432587

ENSG00000104852:SNRNP70:chrl9:+: ENSG00000174483 :BBS1 xhrl 1 :+: ENSG00000127481:UBR4:chrl:-

49605370:49605430:49604728:4960789 66278675:66278710:66278560:6628 : 19476256 : 19476289 : 19475120 : 194

0 1876 77070

ENSG00000266967: AARSD 1 :chrl7: - ENSG00000232560:LINC01549:chr ENSG00000180098:TRNAUlAP:ch :41105740:41105795:41103911:4110717 21:+: 18816400: 18816518: 18811315 rl:+:28901100:28901230:28898412: 4 :18821182 28904011

ENSG00000069275 :NUCKS 1 xhrl :

ENSG00000145362:ANK2:chr4:+:l

ENSG00000156958:GALK2:chrl5:+:49 14253127:114253226:114251626:11 :205698699:205698749:205693109:

575762:49575915:49531564:49584523 4254209 205719084

ENSG00000205531:NAPlL4:chrll: ENSG00000079337:RAPGEF3:chrl

2:-

ENSG00000124222:STX16:chr20:+:572 :2970456:2970494:2966876:297248 :48134424:48134606:48134178:481 46219:57246353:57245659:57248686 8 34697 ENSG00000144744:UB A3 :chr3 :- ENSG00000185008:ROB02:chr3:+: ENSG00000175182:FAM131A:chr3 :69124580:69124661:69120768:6912694 77681624:77681807:77671583:7768 :+:184056174:184056317:18405515 8 4020 9:184059511

ENSG00000107147:KCNTl:chr9:+:138 ENSG00000114062:UBE3A:chrl5:- ENSG00000196776:CD47:chr3:-

661792:138661901:138660783:1386627 :25657054:25657118:25654354:256 : 107768465: 107768498: 107766139:

02 83635 107776323

ENSG00000138814:PPP3CA:chr4:- ENSG00000115041 :KCNIP3 :chr2:+ ENSG00000078018 :MAP2 :chr2 :+:2 : 101950322: 101950352: 101947218: 1019 :95976102:95976268:95963201:960 10588318:210588411:210574978:21 53423 40043 0590432

ENSG00000073536:NLEl:chrl7:- ENSG00000025708:TYMP:chr22:-

ENSG00000174099:MSRB3:chrl2:+:65 :33466838:33467085:33466333:334 :50967924:50968148:50966146:509 702308:65702435 :65672645 :65720605 68997 68332

ENSG00000118473 : SGIP1 xhrl :+:6 ENSG00000105771 : SMG9 xhrl 9

ENSG00000169891:REPS2:chrX:+:1709 7126195:67126207:67109402:67133 :44248923:44249036:44244370:442

2236:17092282:17088116:17121840 212 51593

ENSG00000082397:EPB41L3:chrl ENSG00000077063:CTTNBP2:chr7

8:-

ENSG00000133226:SRRMl:chrl:+:249 :5398019:5398142:5397425:540677 : 117385884: 117385984: 117375475:

73569:24973699:24973280:24975349 5 117396608

ENSG00000148660:CAMK2G:chrl0:- ENSG00000175203:DCTN2:chrl2:- ENSG00000107282:APBAl:chr9>

:75587846:75587879:75581488:7559722 :57935146:57935155:57932307:579 :72073071:72073104:72072055:720

5 39810 82738

ENSG00000106133 :NSUN5P2 :chr7: - ENSG00000181513:ACBD4:chrl7: ENSG00000188385:JAKMIP3:chrl

:72422690:72422834:72420735:7242386 +:43214385:43214506:43214143:43 0:+: 133980486: 133980559: 1339782

4 214734 39:133981456

ENSG00000108387:SEPT4:chrl7:- ENSG00000223705:NSUN5Pl:chr7

ENSG00000101294:HM13:chr20:+:3015 :56604042:56604339:56603674:566 :+:75040937:75041042:75039743:7

5880:30156083:30154098:30156922 08840 5042066

ENSG00000167528:ZNF641:chrl2: ENSG00000234420:ZNF37BP:chrl

ENSG00000139613:SMARCC2:chrl2:- 0:-

:56566720:56566813:56566488:5656747 :48739127:48739257:48738495:487 :43020987:43021108:43019186:430

9 41034 46004

ENSG00000136717:BINl:chr2:- ENSG00000169896:ITGAM:chrl6: ENSG00000075413 :MARK3 :chrl4 : : 127809830: 127809938: 127808819: 1278 +:31332561:31332692:31309275:31 +: 103957288: 103957444: 103946827 15048 332784 : 103958113

ENSG00000070814:TCOFl:chr5:+:1497 ENSG00000142675 :CNKSR1 xhrl : ENSG00000102271 :KLHL4:chrX:+

71106:149771358:149769586:14977151 +:26510561:26510632:26510321:26 :86919763:86919935:86890775:869

9 510704 24328

ENSG00000117616:RSRPl:chrl:- ENSG00000166734:CASC4:chrl5: ENSG00000198932:GPRASPl:chr

:25570944:25570989:25570124:2557164 +:44620882:44620985:44615217:44 X:+: 101907758: 101907826: 1019065

0 671887 23:101908148

ENSG00000080573 :COL5 A3 :chrl9

ENSG00000184271:POU6Fl:chrl2:- ENSG00000074855:AN08:chrl9:- :51585378:51585547:51584375:5158611 : 10116471: 10116661: 10116390: 101 : 17438246: 17438378: 17438154: 174 2 16748 38497 ENSG00000283886 :RP11-

ENSG00000075413:MARK3:chrl4:+:10 204M4.3:chr9:- ENSG00000178538:CA8:chr8:-

3964838:103964865:103958371:103966 :41975030:41975128:41963942:420 :61144842:61144938:61102544:611

492 18927 78483

ENSG00000070718:AP3M2:chr8:+: ENSG00000198929:NOSlAP:chrl:

ENSG00000134717:BTF3L4:chrl:+:525 42011995:42012054:42010623:4201 +: 162330601:162330714: 162326926

25506:52525573:52522051:52530496 2133 : 162335193

ENSG00000235398:LINC00623:chr

ENSG00000085382:HACEl:chr6:- ENSG00000081803 :CADPS2 :chr7 :- 1:- : 105259185: 105259268: 105244900: 1052 : 122120905: 122120914: 122114571: : 144340525: 144340623: 144301536: 80916 122130134 144341669

ENSG00000101203:COL20Al:chr20:+: ENSG00000068024 :HD AC4 : chr2 : - ENSG00000061938:TNK2:chr3:-

61957447:61957501:61952451:6195810 :240066278 :240066410 :240061492 : : 195596367: 195596412: 195595580:

3 240078347 195596984

ENSG00000196295:AC005154.6:chr7:- ENSG00000136699:SMPD4:chr2:- ENSG00000078674:PCM1 :chr8:+: 1

:30618621:30618744:30617707:3061884 : 130918758: 130918845: 130914969: 7793097:17793215:17780697:17794

6 130921946 642

ENSG00000133612:AGAP3:chr7:+:150 ENSG00000141994:DUS3L:chrl9:- ENSG00000115257:PCSK4:chrl9:-

817606:150817832:150817232:1508198 :5786759:5786856:5786553:578707 : 1487601 :1487690: 1487312: 148778

11 1 3

ENSG00000110888:CAPRIN2:chrl

ENSG00000067225 :PKM:chrl 5 : - 2:-

ENSG00000188338:SLC38A3:chr3:+:50 :72495362:72495529:72492996:724 :30872012:30872159:30869610:308 254669:50254752:50253253:50255107 99068 76192 ENSG00000198276 :UCKL 1 :chr20: - ENSG00000122481 :RWDD3 :chrl :+ ENSG00000168661:ZNF30:chrl9:+ :62575005:62575022:62573845:6257574 :95712097:95712213:95699871:957 :35433497:35433577:35424627:354 9 12311 34126

ENSG00000214783:POLR2J4:chr7:- ENSG00000121716 :PILRB : chr7 : +: 9

:44026199:44026276:44012922:4405319 ENSG00000068078:FGFR3:chr4:+: 9951517:99951635:99951106:99952

1 1804640 : 1804791 : 1803752: 1805418 765

ENSG00000011347: SYT7 :chrl 1 : - ENSG00000137502:RAB30:chrll:- ENSG00000144840:RABL3:chr3:- :61313502:61313727:61300596:6131464 :82705080:82705148:82698812:827 : 120412999: 120413071: 120409334: 8 08265 120417269

ENSG00000136059:VILL:chr3:+:38 ENSG00000084693 : AGBL5 :chr2 :+:

ENSG00000082458:DLG3:chrX:+:6971 042412:38042491:38040930:380429 27291915:27291962:27291612:2729 5257:69715303:69713325:69718369 46 2440 ENSG00000159082:SYNJl:chr21:- ENSG00000132470:ITGB4:chrl7:+ ENSG00000166839:ANKDDlA:chr :34017277:34017316:34014276:3401795 :73751135:73751294:73750896:737 15:+:65219099:65219198:65218369

5 51781 :65223019

ENSG00000181929:PRKAGl:chrl2:- ENSG00000184182:UBE2F:chr2:+: ENSG00000114956:DGUOK:chr2:+ :49399525:49399664:49399326:4940684 238903385:238903451:238881867:2 :74177753:74177859:74174033:741 4 38933982 85272

ENSG00000122482:ZNF644:chrl:- ENSG00000091136:LAMBl:chr7:- ENSG00000154358:OBSCN:chrl:+: :91403041:91403647:91383711:9144786 : 107599693: 107599925: 107596075: 228480223 :228480487:228479862:2

6 107600135 28481053

ENSG00000168175:MAPKlIPlL:chrl4: ENSG00000125347:IRFl:chr5:- ENSG00000196586:MY06:chr6:+:7 +:55528397:55528419:55518521:555293 : 131823617: 131823717: 131822822: 6604947:76604977:76602407:76608 35 131826236 089

ENSG00000241231:RP11- ENSG00000196323:ZBTB44:chrll: ENSG00000167524:SGK494:chrl7:

275H4.1:chr3:-

: 181157764: 181157822: 181156487: 1811 : 130130750: 130131824: 130109791: :26940095:26940164:26939705:269 60161 130184269 41104

ENSG00000089022 :MAPKAPK5 :chrl2 : ENSG00000175061 :LRRC75A- +: 112306556: 112306665: 112304035: 112 ASl:chrl7:+: 16342894: 16343017:1 ENSG00000164828:SUNl:chr7:+:8 308074 6342728:16343498 88054:888252:883157:889559 ENSG00000265590:AP000275.65:c hr21:- ENSG00000047849:MAP4:chr3:-

ENSG00000172366:MCRIP2:chrl6:+:69 :33974581:33974677:33954725:339 :47917174:47917390:47913590:479 6471:696608:692043:697416 75470 18906 ENSG00000143093 :STRIP1 :chrl :+: 110 ENSG00000122490:PQLCl:chrl8:- ENSG00000154310:TNIK:chr3:- 584157:110584264:110583325:1105857 :77679183 :77679400:77664183 :776 : 170857258: 170857345: 170856168: 09 93968 170858187

ENSG00000113712:CSNKlAl:chr5:- ENSG00000101849:TBLlX:chrX:+ ENSG00000166295:ANAPC16:chrl : 148897356: 148897440: 148892772: 1488 :9621584:9621729:9608400:962225 0:+:73983645:73983814:73980137: 99852 4 73990123 ENSG00000070808:CAMK2A:chr5

ENSG00000114062:UBE3A:chrl5:-

ENSG00000125388:GRK4:chr4:+:29904 :25652213 :25652284:25650649:256 : 149607754: 149607849: 149602780:

53:2990566:2986335:2993941 53766 149618262

ENSG00000174669:SLC29A2:chrl

ENSG00000196151:WDSUBl:chr2:- ENSG00000213593:TMX2:chrll:+: 1:- : 160114268: 160114375: 160112886: 1601 57505825:57505902:57505140:5750 :66136530:66136602:66136142:661 36271 6602 36839

ENSG00000138709:LARPlB:chr4: ENSG00000115504 :EHBPl:chr2:+:

ENSG00000183597 :TANG02 :chr22 :+:2 +: 129012501 : 129012667: 12901229 63176228:63176297:63175451 :6318

0049052:20049229:20043536:20050860 9:129019340 2651

ENSG00000197989:SNHG12:chrl:- ENSG00000144857:BOC:chr3 :+: 11 ENSG00000185565:LSAMP:chr3:-

:28907605:28907741:28907158:2890810 2991915:112992188:112991550:112 : 115535460: 115535493: 115529261:

1 993221 115553408

ENSG00000137955:RABGGTB:chrl:+: ENSG00000181409:AATK:chrl7:- ENSG00000100379:KCTD17:chr22

76253181:76253289:76251959:7625696 :79100457:79100617:79100360:791 :+:37457143:37457215:37456962:3

9 01382 7457578

ENSG00000153317:ASAPl:chr8:-

ENSG00000162341:TPCN2:chrll:+:688 ENSG00000164818 :DNAAF5 :chr7 : : 131173030: 131173039: 131172210:

52677:68852754:68851484:68902902 +:819589:819781:814799:825153 131179781

ENSG00000196118: CCDC189 :chrl

ENSG00000125454:SLC25A19:chrl7:- ENSG00000124788:ATXNl:chr6:- 6:-

:73273433:73273564:73269720:7327950 : 16753463: 16753578: 16658132: 167 :30770498:30770568:30768975:307

3 61528 71604

ENSG00000122085:MTERF4:chr2:

ENSG00000125347:IRFl:chr5:- ENSG00000114268:PFKFB4:chr3:-

: 131823617: 131823744: 131822822: 1318 :242033691:242033844:242029459: :48562997:48563102:48561263 :485

26236 242036657 72944

ENSG00000125458:NT5C:chrl7:- ENSG00000132906:CASP9:chrl:- ENSG00000100911:PSME2:chrl4:- :73127059:73127200:73126737:7312727 : 15834367: 15834402: 15821947: 158 :24615416:24615449:24613677:246 5 44604 15742

ENSG00000122566:HNRNPA2Bl:chr7: ENSG00000120458:MSANTD2:chr

ENSG00000136280:CCM2:chr7:+:4 11

:26230612:26230748:26230080:2623211 5103516:45103600:45039962:45108 : 124644614: 124644727: 124642950:

4 041 124669766

ENSG00000105538:RASIPl:chrl9: ENSG00000104774:MAN2Bl:chrl

9:-

ENSG00000118473 :SGIP1 :chrl :+:67161 :49230041:49230145:49228217:492 : 12769241: 12769321: 12769158: 127 116:67161176:67154958:67184976 32193 72073

ENSG00000138660:APlAR:chr4:+: ENSG00000181027:FKRP:chrl9:+:

ENSG00000101017:CD40:chr20:+:4475 113184143:113184242:113182018:1 47251771:47251922:47251345:4725

5278:44755340:44751395:44756776 13186164 8668

ENSG00000115977:AAKl:chr2:- ENSG00000167081 :PBX3 :chr9 :+: 1

ENSG00000188766:SPRED3:chrl9:+:38 :69723116:69723212:69693683 :697 28677964:128678206:128510902:12

885282:38885426:38882928:38886119 32700 8691933

ENSG00000214548:MEG3:chrl4:+: ENSG00000152578:GRIA4:chrll:+

ENSG00000187118:CMCl:chr3:+:2836 101298848:101298978:101297871:1 : 105836673 : 105836788: 105804695:

0222:28360370:28357914:28360999 01300968 105842640

ENSG00000084112:SSHl:chrl2:- ENSG00000023171 : GRAMD IB xhr

ENSG00000153707:PTPRD:chr9:- : 109192775: 109192976: 109186605: 11 :+: 123489052: 123489064: 123485

:8454579:8454591:8449837:8460410 109194555 543:123489400

ENSG00000188419:CHM:chrX:- ENSG00000278259:MY019:chrl7:-

ENSG00000034152:MAP2K3:chrl7:+:2 :85133969:85134068:85128217:851 :34856669:34856799:34855004:348

1199397:21199522:21188281:21201724 49192 61135

ENSG00000104852:SNRNP70:chrl9:+: ENSG00000151150:ANK3:chrl0:- ENSG00000120896:SORBS3:chr8:

49605370:49605442:49604728:4960789 :61819455:61819791:61819188:618 +:22424334:22424381:22423385:22

0 22868 424573

ENSG00000133816 :MICAL2 :chrl 1 ENSG00000173418 :NAA20 :chr20 :

ENSG00000101150:TPD52L2:chr20:+:6 :+: 12277189: 12277297: 12270793:1 +:20003099:20003124: 19998093 :20

2507168:62507228:62505169:62520542 2278331 006312

ENSG00000153207:AHCTFl:chrl:- ENSG00000029363 :BCLAF1 :chr6:- ENSG00000155970 :MICU3 :chr8 :+:

:247015206:247015340:247014744:2470 : 136597605: 136597646: 136597127: 16927196:16927228:16921746:1693

16392 136599002 5291

ENSG00000212694 :LINCO 1089 xhr ENSG00000145014:TMEM44:chr3:

ENSG00000172661:WASHC2C:chrl0:+ 12:-

:46282059:46282122:46281079:4628248 : 122240536: 122240712: 122239714: : 194313769: 194313799: 194309368:

2 122240784 194325015 ENSG00000006042:TMEM98:chrl ENSG00000068878 :PSME4 :chr2 :-

ENSG00000266714:MY015B:chrl7:+:7 7:+:31258344:31258420:31255255: :54127017:54127154:54125491:541 3599268:73599393:73599158:73606246 31260191 28486 ENSG00000137726:FXYD6 :chrl 1 : - ENSG00000157827:FMNL2:chr2:+: ENSG00000184156:KCNQ3:chr8:- : 117711058: 117711083: 117710545: 1177 153499932:153500058:153497428:1 : 133184844: 133184940: 133182675: 11862 53504309 133186485

ENSG00000167733 :HSD1 IB lLxhr ENSGOOOOO 134222 :PSRC1 xhrl : -

ENSG00000143344 :RGL 1 :chrl :+: 18386 19:+:5686426:5686538:5681282:56 : 109825301 : 109825358: 109823668: 9283:183869370:183867031:183873983 86910 109825684

ENSG00000110076 :NRXN2:chrl 1 :

ENSG00000130590:SAMD10:chr20:- ENSG00000277791:PSMB3:chrl7:

:62609597:62609714:62608759:6261120 :64460318:64460348:64457948:644 +:36916760:36916861:36912243:36

6 65246 918663

ENSG00000197444:OGDHL:chrl0:- ENSG00000157600:TMEM164:chr ENSG00000247828:TMEM161B-

:50964821:50964992:50960786:5097028 X:+: 109247110: 109247392: 109246 ASl:chr5:+:87705889:87706011:87

4 000:109310574 577923:87732089

ENSG00000127483 :HP1BP3 xhrl :- ENSG00000101152:DNAJC5:chr20 ENSG00000166405:RIC3 xhrl 1 :- :21106842:21107033:21106404:2111368 :+:62562461:62562535:62562375:6 :8148205:8148438:8132684:815892 7 2562817 4

ENSG00000106052:TAXlBPl:chr7 ENSG00000154930:ACSSl:chr20:-

ENSG00000223959:AFG3LlP:chrl6:+:9 :+:27855967:27856139:27839709:2 :25000645 :25000783 :24995866:250

0044046:90044210:90039173:90045217 7867356 11394

ENSG00000148660:CAMK2G:chrl0:- ENSG00000143224:PPOX:chrl:+:l ENSGOOOOO 139793 :MBNL2 xhrl 3 :

:75587846:75587879:75583842:7559722 61137160:161137276:161137024:16 +:98017389:98017425:98009889:98

5 1140409 018712

ENSG00000145349:CAMK2D:chr4:- ENSGOOOOO 164347 : GFM2 : chr5 : - ENSG00000219626 :F AM228B : chr2 : 114376881 : 114376977: 114375671 : 1143 :74034326:74034467:74034242:740 :+:24362239:24362320:24358057:2 78490 35813 4384375

ENSG00000178927:C17oif62:chrl7 ENSG00000183655 :KLHL25 :chrl5 :

ENSG00000103148:NPRL3:chrl6:- :80405455:80405497:80404572:804 :86311247:86313051:86304242:863 : 180520: 180590: 162774: 188148 07045 37996

ENSG00000175265:GOLGA8A:chr

ENSG00000133392:MYHll:chrl6:- ENSG00000162910:MRPL55:chrl:- 15:- : 15826420: 15826565: 15820911:1582922 :228296655:228296722:228296019: :34727583:34727672:34699936:347 2 228296961 29598

ENSG00000133612:AGAP3:chr7:+:150 ENSG00000124787:RPP40:chr6:- ENSG00000075413 :MARK3 :chrl4 :

817606:150817832:150817232:1508208 :4998949:4999075:4996654:500004 +: 103966492: 103966537: 103958371

80 2 :103969218

ENSG00000273590:SMIMllB:chr21:+: ENSG00000175581 :MRPL48:chrl 1 ENSG00000183569:SERHL2:chr22:

35772008:35772197:35757942:3577438 :+:73554291:73554412:73519395:7 +:42962309:42962344:42956271:42

8 3555851 967126

ENSGOOOOO 132004:FBXW9 xhrl 9 :

ENSGOOOOO 134644 :PUM 1 : chr 1 : -

ENSG00000163138 :PACRGL:chr4:+:20 :31452908:31453013:31447649:314 : 12805612: 12805752: 12805536: 128 717729:20717871:20715162:20728907 54158 06986

ENSG00000088451:TGDS:chrl3:- ENSG00000130988:RGN:chrX:+:46

ENSG00000007376:RPUSDl:chrl6:- :95243106:95243197:95235490:952 939715:46940335:46938108:469405

:837076:837179:836928:837353 44494 28

ENSG00000183762:KREMENl:chr ENSGOOOOO 132639: SNAP25 :chr20 :

ENSG00000171612:SLC25A33:chrl:+:9 22:+:29517344:29517469:29494941 +: 10279915: 10280060: 10258374: 10

633403:9633470:9613863:9640011 :29521250 286776

ENSG00000124786:SLC35B3:chr6:

ENSG00000155111:CDK19:chr6:- ENSG00000066027:PPP2R5 Axhrl :

: 111095078: 111095140: 111067404: 1111 :8417634:8417727:8417228:842095 +:212520688:212520748:212519275

36211 3 :212529967

ENSG00000146021:KLHL3:chr5:- ENSG00000187688:TRPV2:chrl7:+

ENSG00000134769:DTNA:chrl8:+:324 : 136972982: 136973084: 136969854: : 16338203: 16338283: 16337012: 163 18708:32418801:32409453:32428259 136974641 40102

ENSG00000174628:IQCK:chrl6:+: ENSG00000059769:DNAJC25:chr9

ENSG00000050426 :LETMD 1 :chrl2 :+: 5 19775356:19775434:19745149:1980 :+: 114405136: 114405374: 11439402 1449926:51450028:51442261:51450132 0159 3:114409386

ENSG00000071462 :WB SCR22 xhr ENSG00000154582:ELOC:chr8:-

ENSG00000095794:CREM:chrl0:+:354 7:+:73098096:73098134:73098003: :74876721:74876860:74868289:748

37295:35437419:35416121:35467816 73106925 84311 ENSG00000184056:VPS33B:chrl5:

ENSG00000138606 : SHF hrl 5 : - ENSG00000203805:PLPP4:chrl0:+: :45464080:45464276:45460331:4546741 :91549881:91549959:91549289:915 122280482:122280607:122263438:1 6 50179 22334642

ENSG00000107957:SH3PXD2A:ch

ENSG00000131778:CHDlL:chrl:+:146 ENSG00000119688:ABCD4:chrl4:- rlO:- 751698: 146751864: 146747921 : 1467570 :74756729:74756821:74756222:747 : 105428365: 105428410: 105420872: 00 56993 105452785

ENSG00000197599:CCDC154:chrl

ENSG00000166266:CUL5:chrll:+:1079 ENSG00000131437:KIF3A:chr5:- 6:- 74916: 107975629: 107969256: 10797693 :132042142:132042151:132039311: : 1485089: 1485170: 1484853 : 148596 3 132044598 9

ENSG00000173480:ZNF417:chrl9:

ENSG00000178104:PDE4DIP:chrl:- ENSGOOOOO 19856 l:CTNNDl:chrll : 144871695: 144871881: 144868172: 1448 :58423427:58423554:58421482:584 :+:57556508:57556627:57529518:5 75976 27746 7561481

ENSG00000257621 :PSMA3- ENSG00000149633:KIAA1755:chr ASl:chrl4:- 20:- ENSG00000136059:VILL:chr3:+:38

: 58759783:58759856:58758425:5876467 :36854066:36854183:36852038:368 044658:38044804:38044066:380457 2 59603 45

ENSG00000125814 :NAPB :chr20 : - ENSG00000109762:SNX25:chr4:+: ENSGOOOOO 176406 :RIMS2 : chr8 : +: :23375775:23375822:23375636:2338362 186272598 : 186272763 : 186267804 : 1 105010412:105010478:105001649:1 9 86278824 05026733

ENSG00000122490:PQLCl:chrl8:- ENSG00000135541:AHIl:chr6:-

ENSG00000159761:C16orf86:chrl6:+:6 :77693968:77694022:77664183:777 : 135644299: 135644462: 135639754:

7701198:67701428:67700975:67701780 03328 135679269

ENSG00000142875:PRKACB:chrl: ENSG00000132670:PTPRA:chr20:+

ENSG00000108509:CAMTA2:chrl7:- +:84640715:84640739:84630105:84 :2928627:2928670:2903931:296741

:4872794:4872815:4872632:4872924 644859 0

ENSG00000166676:TVP23A:chrl6:

ENSG00000120049 :KCNIP2 : chrl 0 : - ENSG00000067113 :PLPP1 :chr5 : - : 103587907: 103588015: 103587750: 1035 : 10868808: 10869404: 10867985: 109 :54786787:54786942:54763977:548 88383 12341 30399

ENSG00000148842:CNNM2:chrl0:+:10 ENSG00000284024 :RP11 - ENSGOOOOO 124313 :IQSEC2:chrX:-

4831530:104831596:104828479:104835 398C13.8:chrlO:+: 14884132: 14884 :53264964:53265014:53257047:532

842 845:14882156:14885369 65503

ENSG00000151150:ANK3:chrl0:-

:61867945:61868044:61865817:6186858 ENSG00000007541:PIGQ:chrl6:+: ENSG00000147364:FBX025:chr8:

7 631198:631341:630972:632882 +:382885:382935:381444:385614

ENSG00000106070:GRB10:chr7:- ENSG00000197381:ADARBl:chr2 ENSG00000197959:DNM3:chrl:+:l

:50772836:50773020:50771605:5082358 l:+:46604388:46604508:46603425: 72292468: 172292480: 172277979: 17

3 46604837 2348157

ENSG00000146112:PPPlR18:chr6:- ENSG00000145819:ARHGAP26:ch ENSG00000072518:MARK2:chrl 1 :

:30652184:30653823:30647166:3065489 r5 :+: 142586762: 142587038: 142526 +:63675731 :63675776:63673586:63

0 946:142593561 676348

ENSG00000080822: CLDND 1 :chr3 :

ENSG00000114062 :UBE3 A:chrl 5 : - ENSG00000175054:ATR:chr3:- :25652213:25652409:25650649:2565423 : 142169307: 142169444: 142168444: :98240496:98240540:98240286:982

4 142171969 41385

ENSGOOOOO 132872: SYT4 :chrl 8: - ENSG00000105426 :PTPRS :chrl 9:- ENSG00000221829:FANCG:chr9:- :40853544:40854305:40851797:4085721 :5256118:5256130:5246056:525802 :35078137:35078340:35077396:350 2 7 78601

ENSG00000196502:SULTlAl:chrl

ENSG00000100842:EFS:chrl4:- 6:- ENSGOOOOO 151466 : SCLT 1 : chr4 : -

:23829763:23830042:23829490:2383421 :28621251:28621512:28620180:286 : 129886381 : 129886473 : 129880932:

6 31383 129891532

ENSG00000128891:C15orf57:chrl5 ENSG00000204427:ABHD16A:chr

6:-

ENSG00000162004:CCDC78:chrl6:- :40845793 : 40846326:40824501 :408 :31669050:31669117:31668805:316 :773856:773936:773161:774321 49414 70926

ENSG00000110888:CAPRIN2:chrl

ENSG00000144959:NCEHl:chr3:- 2:- ENSG00000153201:RANBP2:chr2: : 172365675: 172365904: 172353877: 1724 :30873744:30873849:30869610:308 +: 109378556: 109378651:109375004 28636 76192 : 109379692

ENSG00000226232:NPIPB14P:chrl6:- ENSG00000133627 : ACTR3B :chr7 : ENSG00000103091:WDR59:chrl6:-

:70012124:70012185:70012015:7001625 +: 152497615: 152497740: 15248032 :74933595:74933652:74927710:749

2 7:152498705 42805 ENSG00000110514:MADD:chrll:+ ENSG00000196132 :MYT 1 :chr20 :+:

ENSG00000065882:TBClDl:chr4:+:380 :47295377:47295527:47291797:472 62854643:62854712:62854526:6285

54726:38054846:38053681:38055819 96113 8767

ENSGOOOOO 177303 : CASKIN2 :chrl

ENSG00000181038:METTL23:chrl 7:-

ENSG00000167968:DNASElL2:chrl6:+ 7:+:74725771:74725876:74722961: :73500892:73501154:73500561:735

:2287376:2287477:2287302:2287540 74729059 01637

ENSG00000111412:C12orf49:chrl2 ENSG00000276141 :WHAMMP3 :ch

ENSG00000180902:D2HGDH:chr2:+:24 rl5:-

2688279:242689344:242684292:242689 : 117157567: 117157681: 117155698: :23196161 :23196291 :23194899:232

565 117175594 00236

ENSG00000072803 :FBXW11 :chr5 : ENSGOOOOO 134313 :KIDINS220:chr

ENSG00000010282:HHATL:chr3:- 2:- :42738492:42738637:42738369:4273899 : 171384600: 171384702: 171337801: :8888016:8888130:8877129:889024 9 171433461 1

ENSG00000135749 :PCNX2 :chrl :- ENSG00000174796:THAP6:chr4:+: ENSG00000107147:KCNTl:chr9:+:

:233297016:233297109:233275601:2333 76465068 :76465169 :76447071 :7646 138679945:138680008:138678367:1

13547 7618 38683642

ENSG00000176155:CCDC57:chrl7:- ENSG00000103121:CMC2:chrl6:- ENSG00000005448:WDR54:chr2:+:

:80136349:80136481:80130736:8014164 :81030918:81031034:81010076:810 74649246:74649502:74648943 :7464

9 40338 9996

ENSG00000163607:GTPBP8:chr3:+:112 ENSG00000167608:TMC4:chrl9:- ENSGOOOOO 188906 :LRRK2:chrl2:

711872:112711971:112710182:1127139 :54664614:54664770:54664282:546 +:40707773 :40707975 :40704451 :40

81 64866 709013

ENSG00000150779 :TIMM8B :chrl 1

ENSG00000235954:TTC28- ENSG00000134278:SPIREl:chrl8:- ASl:chr22:+:28318005:28318166:28315 : 111956701 : 111957034: 111956186: : 12485957: 12485999: 12479870: 124 533:28331138 111957363 93070

ENSG00000224016:RP11-

728K20.1:chr7:- ENSG00000148840:PPRCl:chrl0:+

ENSG00000219626:FAM228B:chr2:+:2 : 149589362: 149589487: 149588390: : 103904006: 103904064: 103902855:

4362239:24362320:24358057:24390495 149606738 103906428

ENSG00000177200:CHD9:chrl6:+: ENSG00000164751:PEX2:chr8:-

ENSG00000088854 :C20orfl 94:chr20 : - 53355074:53355129:53352252:5335 :77900542:77900574:77896431:779 :3285086:3285190:3278822:3295679 5437 12225

ENSG00000148541:FAM13C:chrl0

ENSG00000090554:FLT3LG:chrl9:

ENSG00000147576:ADHFEl:chr8:+:67 :61023844:61023926:61014203:610 +:49982165:49982304:49979823:49 352396:67352434:67344810:67356601 28312 983554 ENSG00000115137 :DNAJC27 : chr2 : - ENSG00000047932:GOPC:chr6:- ENSGOOOOO 116698: SMG7 :chrl :+: 1 :25174262:25174423:25170617:2517991 : 117898610: 117898634: 117896515: 83516237:183516387:183515472:18 1 117900062 3518898

ENSG00000176261:ZBTB80S:chrl

ENSGOOOOO 130382 :MLLT1 :chrl 9: -

ENSG00000165233:CARD19:chr9:+:95 :33099245:33099328:33097480:331 :6226987 :6227113 :6222695 :623058 874160:95874220:95870109:95874499 16033 0 ENSG00000060138 : YBX3 :chrl 2 : - ENSG00000186591:UBE2H:chr7:- ENSG00000119866 :BCLllA:chr2:- : 10862506:10862713 :10856747: 1086580 : 129497350: 129497403: 129479175: :60695866:60695968:60679801:607 9 129519407 73105

ENSG00000100211:CBYl:chr22:+: ENSG00000143367:TUFTl:chrl:+:

ENSG00000166199:ALKBH3:chrll:+:4 39061550:39061690:39052755:3906 151535060:151535162:151512902:1

3913590:43913679:43911378:43923065 4021 51536379

ENSGOOOOO 197119 : SLC25 A29 :chr

ENSG00000175395:ZNF25:chrl0:- ENSG00000141480:ARRB2:chrl7: 14:-

: 38256844 :38256867 :38246474 : 3826063 +:4619267:4619328:4614039:46197 : 100761962: 100762330: 100759714:

5 06 100765178

ENSG00000244187 :TMEM141 :chr9 :+: 1 ENSG00000072657:TRHDE:chrl2: ENSG00000279765 :RP11 - 39686162:139686229:139685876:13968 +:73046795:73046936:73046269:73 437B10.1:chrl5:+:93472259:934723 6398 050706 21:93470560:93482807

ENSG00000106976:DNMl:chr9:+:1310 ENSG00000105173:CCNEl:chrl9: ENSG00000168306:ACOX2:chr3:-

15379:131015416:131013219:13101628 +:30312902:30313037:30312724:30 :58516192:58516365:58514683:585

4 313146 16977

ENSG00000106976:DNMl:chr9:+:1310 ENSG00000136444:RSADl:chrl7: ENSG00000152348:ATG10:chr5:+:

15379:131015416:131013219:13101628 +:48557240:48557445:48556380:48 81354313:81354421:81283497:8147

7 559451 4308

ENSG00000119383 :PTPA:chr9:+: 13189 ENSG00000196295:AC005154.6:ch ENSG00000145214:DGKQ:chr4:- 0242:131890347:131885417:131891263 r7:- :957860:957881:957078:958963 :30601081 :30601744:30590397:306 08448

ENSG00000120860:WASHC3:chrl

ENSG00000151150:ANK3:chrl0:- 2:-

ENSG00000157077 :ZFYVE9 :chrl :+: 52 :61828394:61836206:61827767:618 : 102443966: 102444069: 102439897:

732326:52732503:52729544:52734134 40294 102455689

ENSG00000058063:ATPllB:chr3:+:182 ENSG00000122515:ZMIZ2:chr7:+: ENSG00000198556 :ZNF789 :chr7 :+

620268:182620354:182616560:1826316 44799749:44799827:44799059:4480 :99081652:99081766:99077410:990

48 0023 84098

ENSG00000065526:SPEN:chrl:+:l ENSG00000169826:CSGALNACT2

ENSG00000137842:TMEM62:chrl5:+:4 6202696: 16203173 : 16199631 : 16235 :chrl0:+:43662451:43662546:43634

3470804:43470909:43461875:43473378 815 015:43671398

ENSG00000006025 :OSBPL7 :chrl7:

ENSG00000068903 : SIRT2 :chrl 9:-

ENSG00000273611:ZNHIT3:chrl7:+:34 :45897094:45897148:45896465:458 :39384458:39384611:39380784:393

842778:34842810:34842629:34848656 97336 90145

ENSG00000139220 :PPFIA2 : chrl 2 : - ENSG00000183780: SLC35F3 xhrl :

ENSG00000132932:ATP8A2:chrl3:+:26 :81678019:81678082:81675229:816 +:234454496:234454689:234452473

112125:26112199:26107451:26114456 88613 :234455843

ENSG00000143409:MINDYl:chrl:

ENSG00000180098:TRNAUlAP:ch

ENSG00000100938:GMPR2:chrl4:+:24 rl:+:28887624:28887772:28887244: : 150974640: 150974876: 150974258: 703318:24703447:24702804:24704942 28887857 150978787

ENSG00000228315:GUSBPll:chr2

ENSG00000248124:RRN3Pl:chrl6:- 2:- ENSG00000214548:MEG3:chrl4:+:

:21830622:21830802:21830082:2183161 :24036305:24037704:24026054:240 101302072:101302216:101297871:1

5 47615 01302503

ENSG00000110931 :CAMKK2:chrl

ENSG00000163618:CADPS:chr3:- 2:- ENSG00000125675:GRIA3:chrX:+:

:62483820:62483829:62478121:6248483 : 121711858: 121712388: 121708748: 122613913:122614028:122599639:1

6 121734440 22616649

ENSG00000073584:SMARCEl:chrl7:- ENSG00000081692:JMJD4:chrl:- ENSG00000172661 : WASHC2C:chr : 38801827 :38801871 :38793824 : 3880204 :227920629:227920728:227920377: 10:+:46272720:46272873:46268806 7 227921114 :46274400

ENSGOOOOO 167191: GPRC5B :chrl6

ENSG00000124313:IQSEC2:chrX:- ENSG00000168961:LGALS9:chrl7

:53308745:53308958:53296246:5331067 :+:25970550:25970646:25969374:2 : 19893453: 19893623: 19884168: 198

7 5972339 96524

ENSG00000078487 :ZCWPW 1 :chr7

ENSG00000091129:NRCAM:chr7:- ENSGOOOOO 182473 :EX0C7 :chrl7: - : 107807365: 107807518: 107800937: 1078 :100006161:100006282:100004421: :74082934:74082973:74082226:740 16874 100007050 83734

ENSG00000110888:CAPRIN2:chrl2:- ENSG00000119950:MXIl:chrl0:+: ENSG00000279457:RP11-

:30886562:30886645:30884444:3088790 112004585 : 112004631:111988079: 1 34P13.18:chr2:+: 114352626: 114352

1 12038937 738:114346280:114352945

ENSG00000153914:SREKl:chr5:+: ENSG00000002746 :HECW1 :chr7 :+

ENSG00000134851:TMEM165:chr4:+:5 65454636:65454760:65449424:6545 :43519208:43519343:43508704:435

6269402:56269505:56262563:56277780 5046 31673

ENSG00000100320:RBFC)X2:chr22

ENSG00000169727:GPSl:chrl7:+:8

ENSG00000158321:AUTS2:chr7:+:7023 :36146472:36146504:36142608:361 0010134:80010335:80009840:80011

9013:70239085:70236630:70242088 52151 149

ENSG00000121578 :B4GALT4:chr3

ENSG00000167281:RBFOX3:chrl7:- ENSGOOOOO 129116 :PALLD :chr4 :+: :77231847:77231887:77111830:7730380 : 118937558: 118937619: 118935191: 169846383 :169846429: 169846229: 1 5 118942904 69847363

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000076043 :REX02:chrl 1 : ENSG00000204843 :DCTN1 :chr2:- : 131201283: 131201346: 131199390: 1312 +: 114315262: 114315374: 11431146 :74600054:74600075 :74598855 :746 01593 1:114316700 18920

ENSG00000107679:PLEKHAl:chrl0:+: ENSG00000182872:RBM10:chrX:+ ENSG00000214078:CPNEl:chr20:-

124187791:124187832:124186547:1241 :47030426:47030657:47028897:470 :34243123:34243266:34220845:342

89139 32526 52723

ENSG00000160325:CACFDl:chr9:+:13 ENSG00000064225 : ST3 GAL6 :chr3 ENSGOOOOO 168502 :MTCL 1 xhrl 8 :

6330443:136330569:136328677:136333 :+:98489964:98490034:98489800:9 +:8792995:8793118:8784841:87962

042 8491656 29 ENSG00000163618:CADPS:chr3:- ENSG00000059145:UNKL:chrl6:- ENSG00000213593:TMX2:chrll:+:

:62452972:62452987:62452088:6245984 : 1463846: 1464010: 1453345: 146461 57505257:57505498:57505140:5750

7 5 5825

ENSG00000259024 :TVP23 C-

ENSG00000070669:ASNS:chr7:- CDRT4:chrl7:- ENSG00000134452:FBXO18:chrl0:

:97499089:97499125:97498417:9750166 : 15456998: 15457143: 15450462: 154 +:5944982:5945138:5932309:59479

2 58595 99

ENSG00000110011 :DNAJC4:chrl 1 ENSG00000132600 :PRMT7 :chrl6:

ENSG00000171608:PIK3CD:chrl:+:978 :+:63999901:64000086:63999436:6 +:68381113:68381197:68380183:68

4026:9784150:9783350:9784333 4001365 382244

ENSG00000120694:HSPHl:chrl3:- ENSG00000148498:PARD3:chrl0:-

ENSG00000134265:NAPG:chrl8:+:105 :31725745:31725879:31725328:317 :34573062:34573173 :34420511 :346 30766:10530834:10526155:10539758 28769 06034 ENSG00000145439:CBR4:chr4:- ENSG00000151490:PTPRO:chrl2: ENSG00000186088:GSAP:chr7:- : 169928786: 169928907: 169928042: 1699 +: 15722350: 15722432: 15718562: 15 :76958649:76959684:76955590:769 31098 731786 78667

ENSG00000137877 : SPTBN5 :chrl 5 :

ENSG00000164061:BSN:chr3:+:49

ENSG00000072134 :EPN2 :chrl 7 : +: 1918 :42153932:42154121:42153694:421 700308:49701099:49699995:497012 5267:19185390:19140844:19213197 54327 19 ENSG00000198646 :NCOA6 :chr20 :- ENSG00000166979:EVAlC:chr21: ENSG00000171189:GRIKl:chr21:- :33328166:33331145 :33324562:3333461 +:33873724:33873848:33867480:33 :30910118:30910205:30909706:309 0 887123 27372

ENSG00000110427 :KIAA1549L :chrl 1 : ENSG00000108262:GITl:chrl7:- ENSG00000124006 :OB SL 1 :chr2: - +:33620365:33620493:33596419:336281 :27905979:27906006:27905797:279 :220419195:220419462:220417746: 86 08355 220420741

ENSG00000087085:ACHE:chr7:- ENSG00000119844:AFTPH:chr2:+: ENSG00000164776:PHKGl:chr7:- : 100489954: 100490175: 100488959: 1004 64808323:64808407:64806680:6481 :56154662:56154717:56151408:561 90785 2555 55290

ENSG00000002919:SNXll:chrl7:+ ENSGOOOOO 103121 : CMC2 : chrl 6 : -

ENSG00000153914:SREKl:chr5:+:6545 :46188069:46188129:46185200:461 :81031889:81032078:81031034:810

1892:65454760:65449424:65455046 89392 40338

ENSG00000133943:C14orfl59:chrl ENSG00000123159:GIPCl:chrl9:-

ENSG00000140995:DEF8:chrl6:+:9001 4:+:91614124:91614202:91580872: : 14593500: 14593818: 14591590: 146

5824:90015921:90015222:90021576 91623982 02467

ENSG00000204681:GABBRl:chr6: ENSG00000205593:DENND6B:chr

ENSG00000158555:GDPD5:chrll:- 22 :75150384:75150399:75148093:7515092 :29596863 :29596884:29595423 :295 :50754994:50755055:50754904:507 3 99172 55721

ENSG00000157890:MEGFll:chrl5:- ENSG00000197586:ENTPD6:chr20 ENSG00000085978:ATG16Ll:chr2:

:66208935:66209294:66208614:6621030 :+:25187711 :25188033 :25176503 :2 +:234182366:234182423:234181698

3 5190484 :234183321

ENSG00000153066:TXNDCll:chrl6:- ENSG00000123179:EBPL:chrl3:- ENSG00000143549:TPM3:chrl:- : 11794307: 11794420: 11792181: 1181543 :50237192:50237331:50235344:502 : 154141780: 154141859: 154130197: 2 65389 154142875

ENSG00000100429:HDAC10:chr22

ENSG00000167522:ANKRDll:chrl6:- ENSG00000052795:FNIP2:chr4:+:l : 89352446:89352594:89341599: 8935493 59754952:159755042:159754780:15 :50687531:50687627:50687319:506 5 9756556 87756

ENSG00000143774:GUKl:chrl:+:2

ENSG00000142197:DOPEY2:chr21:+:3 28336071:228336240:228335400:22 ENSG00000133256:PDE6B:chr4:+:

7586378:37586488:37584395:37586739 8336365 661644:661795:660403:663834

ENSG00000138107:ACTRlA:chrl0

ENSG00000143669:LYST:chrl:- ENSG00000136243:NUPL2:chr7:+: :235894331:235894477:235894243:2358 23236298:23236385:23226765:2323 : 104241593 : 104241655: 104240929: 97129 9076 104242767

ENSG00000167548:KMT2D:chrl2:- ENSG00000095794:CREM:chrl0:+ ENSG00000141376:BCAS3:chrl7:+

:49417835:49417883:49416658:4941836 :35490378:35490414:35416121:354 :59465978:59466069:59161925:594

0 95822 69337

ENSG00000078487 :ZCWPW 1 :chr7 ENSG00000163528:CHCHD4:chr3:

ENSG00000132670 :PTPRA:chr20 :+:294 : 100013597: 100013720: 100007167: : 14163416: 14163586: 14158024: 141 4917:2944996:2903931:2967410 100017252 66154

ENSG00000142188:TMEM50B:chr

ENSG00000138101:DTNB:chr2:- ENSG00000044115: CTNNA1 : chr5 : 21:- :25678273 :25678363 :25674504:2570566 +: 138216733: 138216826: 13821128 :34819324:34819447:34811604:348 4 6:138221900 21088 ENSG00000104888:SLC17A7:chrl

ENSG00000152061 :RABGAPlL:chrl :+: ENSG00000060237:WNKl:chrl2:+ 9:- 174957777: 174957975 : 174952042: 1749 : 1010726: 1010798: 1009836: 101701 :49934594:49934705:49934399:499 58985 2 35775

ENSG00000078549:ADCYAP1R1: ENSG00000147649:MTDH:chr8:+:

ENSG00000157734:SNX22:chrl5:+:644 chr7:+:31139740:31139824:311323 98711981:98712080:98703416:9871

44441:64444525:64444049:64445443 49:31142850 8853

ENSG00000162341 :TPCN2:chrl 1 :+ ENSGOOOOO 187735 :TCEA1 :chr8 :-

ENSG00000144550:CPNE9:chr3:+:9757 :68825045:68825162:68816574:688 :54915451:54915500:54912610:549 657:9757719:9757210:9758741 30351 34622 ENSG00000140157 :NIP A2 : chrl 5 : - ENSG00000008838:MED24:chrl7:- ENSG00000064607:SUGP2:chrl9:- :23033277:23033413:23021429:2303414 :38191168:38191225:38189709:381 : 19102148: 19102362: 19101958: 191 6 91369 05174

ENSG00000117481 :NSUN4:chrl :+: ENSG00000100416:TRMU:chr22:+

ENSG00000156639:ZFAND3:chr6:+:37 46812592:46812747:46810634:4681 :46739158:46739265:46733841:467

897734:37897775:37787792:38029368 8539 42318

ENSG00000255036:RP11- ENSG00000028203:VEZT:chrl2:+:

ENSG00000172995:ARPP21:chr3:+:357 23J9.4:chr9:+: 100126299: 10012641 95650929:95651015:95645847:9565

78669:35778854:35771028:35780808 0:100124723:100127954 6681

ENSG00000160055:TMEM234:chr

ENSG00000064995 :TAF11 :chr6:- 1:-

ENSG00000082397:EPB41L3:chrl8:- :34847743:34847840:34846497:348 :32681984:32682118:32681882:326

:5415816:5416377:5410618:5419709 48065 82489

ENSG00000147100:SLC16A2:chrX ENSGOOOOO 176406 :RIMS2 : chr8 : +:

ENSG00000169598:DFFB:chrl:+:37890 :+:73749047:73749276:73745728:7 105080739:105080840:105026843:1

35:3789136:3786339:3800070 3751167 05257143

ENSG00000122203 :KIAA1191 :chr 5:- ENSGOOOOO 136104:RNASEH2B :ch

ENSG00000178971:CTCl:chrl7:- : 175786483 : 175786570: 175777740: rl3:+:51501542:51501614:5148427

:8139148:8139277:8138603:8139375 175788604 6:51517456

ENSG00000069998 :HDHD5 :chr22 :

ENSG00000152154:TMEM178A:chr2:+ ENSG00000161912:ADCY10Pl:chr

:39934188:39934326:39893514:3994414 : 17623987: 17624021: 17619628: 176 6:+:41105961:41106080:41105299:

9 25913 41106346

ENSG00000131373:HACLl:chr3:- ENSG00000136682:CBWD2:chr2:+ ENSG00000100095:SEZ6L:chr22:+ : 15626754: 15626849: 15624496: 1563104 : 114228609 : 114228666 : 114222750 : :26761337:26761532:26747209:267 6 114239753 69416

ENSG00000153391:IN080C:chrl8:

ENSG00000075539:FRYL:chr4:- ENSG00000151914:DST:chr6:-

:48504844:48504862:48503750:4850756 :56394245:56394572:56393723:563 :33067349:33067403:33060527:330

3 94771 77682

ENSG00000125462:Clorf61:chrl:- ENSG00000221829 :F ANCG: chr9 : - ENSGOOOOO 158882 :TOMM40L :chr : 156376871 : 156376989: 156374393 : 1563 :35076720:35076867:35076580:350 1:+: 161197047: 161197140: 1611967 77633 77260 45:161197673

ENSG00000255339:RP11-

ENSG00000117419 :ERI3 : chrl : - 411B6.6:chrlO:- ENSGOOOOO 118194 :TNNT2 :chrl :-

:44818521:44818597:44785416:4482056 : 102267181 : 102267324: 102266177 : :201338943:201338973:201337355:

3 102267664 201341154

ENSG00000187672:ERC2:chr3:- ENSGOOOOO 172765 :TMCC1 :chr3 :-

ENSG00000116698:SMG7:chrl:+: 18351 :55717821:55717887:55640994:557 : 129546645: 129547351:129390107: 6237:183516387:183515472:183518342 33405 129551616

ENSG00000130477:UNC13A:chrl9

ENSG00000138303:ASCCl:chrl0:-

ENSG00000167978:SRRM2:chrl6:+:28 : 17786820: 17786850: 17785565: 177 :73975539:73975612:73973089:739 18505:2818600:2818262:2818997 98986 75964 ENSG00000139631:CSAD:chrl2:- ENSG00000176406:RIMS2:chr8:+: ENSG00000169689:CENPX:chrl7:- :53565109:53565225:53564286:5356566 105106705:105106957:105105871:1 :79977516:79977570:79977257:799 5 05160834 80701

ENSG00000243156 :MICAL3 :chr22 : - ENSG00000135723:FHODl:chrl6:- ENSG00000044115: CTNNA1 :chr5 : : 18305712: 18305826: 18304936: 1831461 :67270313 :67270337:67268375 :672 +: 138216733: 138216826: 138211427 9 70459 :138221900

ENSG00000167106:FAM102A:chr9

ENSG00000142733:MAP3K6:chrl:- ENSG00000101190:TCFL5:chr20:- :27691151:27691175:27690885:2769126 : 130710646: 130710693: 130708032: :61488746:61488990:61485509:614 3 130712701 91476 ENSG00000010803 :SCMH1 :chrl ENSG00000094631 :HD AC6 :chrX:+ :41625396:41625605:41617356:4162654 ENSG00000166402:TUB:chrll:+:8 :48676626:48676819:48676516:486 6 117044:8117212:8115736:8118231 78512

ENSG00000143951:WDPCP:chr2:- ENSG00000185414:MRPL30:chr2:

ENSG00000048342:CC2D2A:chr4:+:15 :63380629:63380709:63380080:634 +:99802639:99802717:99797712:99 480846:15480952:15480430:15482327 01804 811213 ENSG00000080822:CLDND1 :chr3 :- ENSG00000108231 :LGI1 :chrl0:+:9 ENSG00000088986:DYNLLl:chrl2 :98240496:98240562:98240286:9824138 5518516:95519048:95518116:95537 :+: 120926380: 120926456: 12092598 5 135 0:120934218

ENSG00000133318:RTN3:chrll:+: ENSG00000255036:RP11-

ENSG00000196220 : SRGAP3 : chr3 : - 63472322:63472379:63449250:6348 23 J9.4:chr9:+: 100105621: 10010584 : 9069783 : 9069814 : 9068679 : 9074333 6452 5:100093049:100109595 ENSG00000155508:CNOT8:chr5:+:154 ENSG00000101190 : TCFL5 : chr20 : - ENSG00000175287:PHYHDl:chr9: 242771:154242955:154238376:1542447 :61490715:61490878:61473449:614 +: 131702647: 131702776: 131698924 51 91476 : 131702877

ENSG00000111906 :HDDC2 : chr6 : - ENSG00000178053 :MLF1 :chr3 :+: 1

ENSG00000225783:MIAT:chr22:+:2706 : 125619859: 125619962: 125614055: 58306640:158306713:158289136:15

3147:27063273:27062900:27064120 125621683 8310222

ENSG00000124222:STX16:chr20:+ ENSGOOOOO 168675 :LDLRAD4:chr

ENSG00000163517 :HD AC11 :chr3 :+: 13 :57234678:57234690:57227143:572 18:+: 13643357: 13643411:13621270

538235:13538352:13525064:13544383 42545 :13645125

ENSG00000197536:C5orf56:chr5:+:131 ENSG00000185189:NRBP2:chr8:- ENSG00000196914:ARHGEF12:ch

785341:131785381:131755632:1318113 : 144917989: 144918045: 144917900: rll:+: 120300420: 120300540: 12030

58 144918136 0226:120302479

ENSG00000137877:SPTBN5:chrl5:

ENSG00000144034:TPRKB:chr2:-

ENSG00000153707:PTPRD:chr9:- :73959710:73959827:73959412:739 :42143051:42143137:42140826:421

:8454579:8454594:8449837:8460410 61555 43256

ENSG00000234899:SOX9-

ASl:chrl7:- ENSG00000006282: SPATA20 :chrl

ENSG00000205726:ITSNl:chr21:+:351 :70070689:70072874:70067372:700 7:+:48625080:48625128:48624646: 99121:35199167:35191627:35201927 78061 48625643 ENSG00000198399:ITSN2:chr2:- ENSG00000125733:TRIP10:chrl9: ENSG00000188878:FBFl:chrl7:- :24507631 :24507712:24498718:2450908 +:6746039:6746207:6745005:67464 :73931712:73931754:73929169:739 0 62 33646

ENSG00000095637:SORBSl:chrl0:- ENSG00000128596:CCDC136:chr7 ENSGOOOOO 139793 :MBNL2 :chrl 3 : : 97096277 : 97097051 : 97081778 : 9709888 :+: 128457811:128457918: 12845598 +:98018712:98018807:98009889:98 9 5:128461852 043575

ENSG00000084234:APLP2:chrll:+:129 ENSGOOOOO 196873 :CBWD3:chr9:+

993506:129993674:129992408:1299965 ENSG00000214021 :TTLL3 :chr3 :+: :70871836:70871896:70863813:708

94 9859328:9860604:9855029:9868680 73447

ENSG00000153291:SLC25A27:chr ENSGOOOOO 154222 :CC2D IB :chrl : -

ENSG00000166949:SMAD3:chrl5:+:67 6:+:46638862:46638965:46636530: :52822672:52822846:52822114:528

457590:67457722:67457426:67459116 46644383 23197

ENSG00000228486:LINC01125:chr2:+: ENSG00000172766 :NAA16 :chrl 3 : ENSG00000138709:LARPlB:chr4:

98306718:98306790:98292391:9831761 +:41936866:41937009:41936295:41 +: 129131010: 129131148: 129128538

6 941574 :129141509

ENSG00000240344:PPIL3:chr2:- ENSG00000134905:CARS2:chrl3:- ENSGOOOOO 175061 :LRRC75A- :201747064:201747105:201746211:2017 : 111350264: 111350314:111340365 : AS1 :chrl7:+: 16342841 : 16343017 : 1 50420 111353784 6342728:16343498

ENSG00000159346:ADIPORl:chrl:- ENSG00000156976:EIF4A2:chr3:+: ENSGOOOOO 130723 :PRRC2B :chr9 :

:202923368:202923435:202920292:2029 186502750:186502890:186502485:1 +: 134349840: 134351922: 134349111

27312 86503671 : 134353130

ENSG00000223797:ENTPD3-

ASl:chr3:- ENSG00000055070:SZRDl:chrl:+:

:40493195 :40493273 :40441119:4049461 16717869:16717919:16693803:1671 ENSG00000159788:RGS12:chr4:+: 2 9725 3388142:3388164:3372048:3415798

ENSG00000178104:PDE4DIP:chrl:- ENSG00000055070:SZRDl:chrl:+: ENSG00000160766:GBAPl:chrl:- : 144871695: 144871881: 144866723: 1448 16717869:16717919:16693803:1671 : 155188178: 155188270: 155187840: 73876 9722 155188638

ENSG00000173540:GMPPB:chr3:- ENSG00000181163 :NPM1 :chr5 :+: 1 ENSG00000134058:CDK7:chr5:+:6

:49759864:49759943:49759580:4976002 70817078:170817134:170815010:17 8548244:68548278:68531280:68553

8 0818308 869

ENSG00000196312:MFSD14C:chr9 ENSG00000120860:WASHC3:chrl

ENSG00000143537:ADAM15:chrl:+:15 2:-

5034379:155034593:155033308:155034 :99735134:99735230:99721179:997 : 102455025: 102455124: 102444069:

720 75540 102455689 ENSG00000270898:GPR75-

ASB3:chr2:- ENSG00000163875:MEAF6:chrl:- ENSG00000150471 : ADGRL3 :chr4 :

:53992513:53992722:53978078:5408696 :37962147:37962205:37961519:379 +:62778436:62778475:62775463 :62

4 62307 800557

ENSG00000206562:METTL6:chr3 : ENSG00000132694:ARHGEFll:ch rl>

ENSG00000101413:RPRDlB:chr20:+:3 :15457004: 15457090: 15456421 :154 : 156941488: 156941608: 156939835:

6676749:36676883:36662500:36685933 57278 156946774

ENSG00000169862:CTNND2:chr5: ENSG00000143797:MBOAT2:chr2:

ENSG00000266173:STRADA:chrl7:-

:61800657:61800686:61791468:6180399 : 11083992: 11084067: 11082958: 110 :9098625:9098771:9083393:914366

7 98686 8

ENSG00000232560:LINC01549:chr21:+ ENSG00000186642:PDE2A:chrll:- ENSG00000101746:NOL4:chrl8:- : 18816400: 18816518: 18814161: 1882118 :72342121 :72342183:72319795:723 :31708812:31708853:31685124:317 2 53297 09834

ENSG00000084636:COL16Al:chrl

ENSG00000022976:ZNF839:chrl4:+:10 ENSG00000103550:KNOPl:chrl6:-

2802971:102803056:102802175:102805 :32163506:32163773:32162901:321 : 19722693 :19722762:19718543 : 197

152 65413 25439

ENSG00000128739 : SNRPN hrl 5 : ENSG00000136504:KAT7:chrl7:+:

ENSG00000160094:ZNF362:chrl:+:337 +:25219533:25219603:25213229:25 47886480:47886570:47882807:4788 36087:33736213:33722255:33741700 221451 8837 ENSG00000114062 :UBE3 A:chrl 5 : - ENSG00000111711 :G0LT1B :chrl2 ENSG00000145730:PAM:chr5:+:10 :25652213:25652359:25650649:2565376 :+:21659818:21659910:21654882:2 2363888:102363942:102361038:102 6 1665228 364590

ENSG00000086758:HUWEl:chrX:- ENSG00000038219:BODlLl:chr4:- ENSG00000197037:ZSCAN25:chr7

:53570846:53570929:53569500:5357339 : 13574325: 13574466: 13571752: 135 :+:99216670:99216755:99216274:9

6 78461 9217183

ENSG00000166676:TVP23A:chrl6:- ENSG00000250305:KIAA1456:chr ENSG00000135124:P2RX4:chrl2:+ : 10911959: 10912039: 10867985: 1091234 8:+: 12848342: 12848509: 12809867: : 121660749: 121660846: 121659969: 1 12863710 121666335

ENSG00000204790 :CBWD6 :chr9 :- ENSG00000126653:NSRPl:chrl7:+

ENSG00000167280:ENGASE:chrl7:+:7 :69247521:69247581:69245978:692 :28445097:28445191:28443881:284

7079563:77079672:77079205:77079842 55603 90084

ENSG00000164877:MICALL2:chr7

ENSG00000141378:PTRH2:chrl7:- ENSG00000145087 : STXBP5L :chr3 :57776231:57777550:57775339:5778473 :+: 120969569: 120969610: 12095935 : 1474736: 1474783 : 1474308: 147637

1 4:120973741 7

ENSG00000102984:ZNF821:chrl6> ENSG00000085978:ATG16Ll:chr2 ENSG00000112339:HBSlL:chr6:-

:71895678:71895845:71894575:7189804 :+:234182636:234182687:23418242 : 135290375: 135290476: 135287611:

0 3:234183321 135299816

ENSG00000170873:MTSSl:chr8:- ENSG00000177410 :ZF AS 1 : chr20 : +

ENSG00000164742:ADCYl:chr7:+:457 : 125570953: 125571073: 125568646: :47897439:47897501:47897107:479

50126:45750251:45748063:45753291 125575022 05581

ENSG00000163697:APBB2:chr4:- ENSG00000147576:ADHFEl:chr8:

ENSG00000257103:LSM14A:chrl9:+:3 :40937093:40937156:40936716:409 +:67352396:67352434:67344810:67

4717312:34717369:34712643:34718269 46881 355032

ENSG00000165868:HSPA12A:chrl ENSG00000174606:ANGEL2:chrl:

ENSG00000118454:ANKRD13C:chrl:- 0:- :70781163:70781249:70766591:7079053 : 118441301: 118441388: 118440767: :213174127:213174254:213173725: 5 118443301 213178374

ENSG00000104218:CSPPl:chr8:+: ENSG00000183579 :ZNRF3 :chr22 :+

ENSG00000143774:GUKl:chrl:+:22832 68062017:68062170:68049838:6806 :29442703:29442871:29439418:294

9326:228329530:228328989:228333211 6258 44376

ENSG00000115289:PCGFl:chr2:- ENSG00000135127:BICDLl:chrl2:

ENSG00000147526:TACCl:chr8:+:3869 :74732678:74732765:74732546:747 +: 120528714: 120528823: 120527875

7741:38697785:38693805:38699804 33078 : 120530803

ENSG00000197444:OGDHL:chrl0:

ENSG00000162735:PEX19:chrl:- ENSG00000169169:CPTlC:chrl9:+ : 160253319: 160253429: 160252899: 1602 :50957771:50957862:50955254:509 :50195077:50195210:50194597:501 54844 58884 95495

ENSG00000198270:TMEM116:chr

ENSG00000143486 :EIF2D : chrl : - 12:- ENSG00000088367:EPB41Ll:chr20

:206772816:206772966:206772446:2067 : 112374545: 112374634: 112371834: :+:34788794:34788899:34785963:3

73616 112374963 4800193 ENSG00000239382:ALKBH6:chrl9:- ENSG00000113763 :UNC5A:chr5:+ ENSG00000149657:LSM14B:chr20

:36501795:36501979:36501547:3650392 : 176304535 : 176304704: 176304280: :+:60702640:60702757:60699836:6

2 176304894 0704840

ENSG00000253771:TPTE2Pl:chrl

ENSG00000019144 :PHLDB 1 :chrl 1 :+: 1 3:- ENSG00000067141:NE01:chrl5:+: 18515364:118515409:118514892:11851 :25517069:25517159:25516246:255 73567032:73567065:73566346:7357 6073 25534 0471

ENSG00000283486:RP11- ENSG00000075303:SLC25A40:chr

392E22.9:chr9:- 7:-

ENSG00000165629:ATP5Cl:chrl0:+:78 :38541285:38541559:38540846:385 : 87471246 : 87471356 : 87471029: 874 38083:7838118:7830226:7840952 42308 73068 ENSG00000054277 :OPN3 :chrl :- ENSG00000129103:SUMF2:chr7:+: ENSG00000090661 :CERS4 :chrl9 :+ :241767561:241767881:241761299:2418 56142278:56142332:56141911:5614 :8315927:8316133:8274378:831938 03183 4526 2

ENSG00000149743 :TRPT1 :chrl 1 ENSG00000205707:ETFRFl:chrl2: ENSG00000184674 : GSTT 1 :chr22 : - :63992266:63992442:63992189:6399297 +:25356658:25356766:25348271:25 :24381699:24381787:24379450:243 0 356853 84119

ENSG00000118200:CAMSAP2:chrl:+:2 ENSG00000185518:SV2B:chrl5:+: ENSG00000160439:RDH13:chrl9:-

00797700:200797733:200784772:20080 91769102:91769944:91643593:9179 :55570524:55570643:55568176:555

1327 5048 74335

ENSG00000115355 :CCDC88A:chr

ENSG00000176261:ZBTB80S:chrl:- 2:- ENSG00000155366:RHOC:chrl:- :33093108:33093145:33087549:3311603 :55530204:55530288:55529208:555 : 113247721: 113247790: 113246428: 3 35944 113249699

ENSG00000079156:OSBPL6:chr2:+:179 ENSG00000197106: SLC6A17:chrl :

188903:179188996:179171013:1791929 ENSG00000130731:METTL26:chrl +: 110734593 :110734835:110719361

82 6:-:685611:685774:684797:686093 :110735127 ENSG00000170852:KBTBD2:chr7:

ENSG00000124406 : ATP8 A1 : chr4 : - ENSG00000079691 : C ARMIL 1 : chr6 :42571177:42571222:42558057:4257663 :32919046:32919554:32914769:329 :+:25612967:25613114:25610409:2

5 31147 5619674

ENSG00000182985: CADMl :chrl 1 :

ENSG00000176444:CLK2:chrl:- ENSG00000061918:GUCYlB3:chr : 155236519: 155236686: 155234565: 1552 4:+: 156680938: 156681012: 1566802 : 115061607: 115061661 : 115049495: 37800 95:156696119 115085327

ENSG00000054965:FAM168A:chrll:- ENSG00000197971:MBP:chrl8:- ENSG00000087470:DNMlL:chrl2: :73131934:73131946:73131044:7313606 :74700832:74700868:74692427:747 +:32890798:32890876:32890095:32

6 28787 891197

ENSG00000235257:ITGA9-

ENSG00000103121:CMC2:chrl6:- ENSG00000221988 :PPT2 :chr6 :+: 32 ASl:chr3:- :81031889:81031956:81015482:8104033 122806:32122960:32122554:321235 :37876169:37876258:37862591:379 8 44 03191

ENSG00000197622 :CDC42SE1 :chr 1:-

ENSG00000037474:NSUN2:chr5:- ENSG00000242802: AP5Z1 :chr7 :+: : 151029131:151029262: 151026797:

:6622128:6622213:6620411:6623326 4830089:4830222:4829560:4830440 151031954

ENSG00000144034:TPRKB:chr2:- ENSG00000047849:MAP4:chr3:- ENSG00000181027:FKRP:chrl9:+:

:73961654:73961718:73959412:7396442 :47910703:47910817:47899002:479 47251771:47252141:47251345:4725

8 12302 8668

ENSG00000185596:WASH3P:chrl5:+:l ENSG00000167130 :DOLPP 1 :chr9 : ENSG00000272888 :LINC01578:chr

02513794:102513930:102513555:10251 +: 131847485: 131847585: 13184704 15:+:93426814:93427008:93426416

4107 7:131847796 :93428744

ENSG00000093167 :LRRFIP2 :chr3 :

ENSG00000154556:SORBS2:chr4:-

ENSG00000073670: ADAMl 1 :chrl7:+:4 :37114280:37114373:37107433:371 : 186544067: 186545648: 186541305: 2852951:42853044:42852833:42854112 16514 186547985 ENSG00000138606 : SHF hrl 5 : - ENSG00000166411:IDH3A:chrl5:+ ENSG00000168958:MFF:chr2:+:22 :45465773:45465914:45464516:4546741 :78449249:78449504:78447617:784 8211941:228212100:228207535:228 6 49889 220392

ENSG00000268350:FAM156A:chr

X:- ENSG00000104835:SARS2:chrl9:-

ENSG00000148053:NTRK2:chr9:+:872 :52984351:52984444:52977913:529 :39408733:39408779:39408473:394

84216:87284338:87283700:87284594 85470 09061

ENSG00000143416:SELENBPl:chr

ENSG00000245937:LINC01184:chr5:- 1:- ENSG00000090661 :CERS4 :chrl9 :+ : 127396835: 127396936: 127302620: 1274 : 151338750: 151338929: 151338322: :8306224:8306341:8274378:831595 18426 151339197 9 ENSG00000272752: STAG3L5P- PVRIG2P- ENSG00000112983 :BRD8:chr5 :- ENSG00000147419:CCDC25:chr8:-

PILRB:chr7:+:99950995:99951635:9995 : 137502206: 137502299: 137501797: :27614235:27614287:27610104:276 0746:99952765 137503622 19935

ENSG00000070610:GBA2:chr9:- ENSGOOOOO 113240 : CLK4 : chr5 : - ENSG00000125462:Clorf61:chrl:-

:35740522:35740625:35740359:3574082 : 178046838: 178047674: 178045779: : 156384445: 156384545: 156374393:

1 178050256 156389962

ENSG00000143850:PLEKHA6:chr

ENSG00000180098:TRNAUlAP:chrl:+ 1:- ENSG00000204469:PRRC2A:chr6:

:28898378:28898412:28893925:2890401 :204220658:204220739 :204219742 : +:31602248:31602334:31602142:31

1 204226480 602529

ENSG00000168016:TRANKl:chr3:- ENSG00000038002 : AGA:chr4 :- ENSG00000119640: ACYPl:chrl4:-

:36879862:36879995:36876398:3688010 : 178357429: 178357505: 178355643: :75528386:75528465:75520362:755

3 178358558 30172

ENSGOOOOO 153406 :NMRAL 1 : chr 1

ENSG00000087085:ACHE:chr7:- 6:- ENSG00000198722:UNC13B:chr9: : 100490307: 100490439: 100488959: 1004 :4513678:4513851:4511960:451615 +:35364541:35364564:35313986:35 90785 3 366943

ENSG00000138674 : SEC31 A:chr4 : - ENSG00000090565 :RAB 11FIP3 :ch ENSG00000172803:SNX32:chrll:+ :83782783:83782861:83778917:8378447 rl6:+:541133:541268:539000:55300 :65616948:65617053:65601572:656 0 3 17901

ENSG00000108352:RAPGEFLl:chrl7:+ ENSG00000112357 :PEX7:chr6:+:l ENSG00000149657:LSM14B:chr20

:38349614:38349669:38348945:3834991 37193335:137193391:137147607:13 :+:60702640:60702757:60701495:6

5 7219279 0705274

ENSG00000180957:PITPNB:chr22:

ENSG00000124126:PREXl:chr20:- ENSG00000058600 :POLR3E:chrl6 :

:47364345:47364417:47361684:4744417 :28250841 :28250927:28249651 :282 +:22339830:22339908:22337599:22

8 54374 344964

ENSG00000139620 :KANSL2 :chr 12 : - ENSG00000095574:IKZF5:chrl0:- ENSG00000244560:RP4-

:49072818:49073021:49065745:4907343 : 124766541 : 124766692: 124758187 : 800G7.2:chr7:+: 148986638: 1489868

7 124768209 17:148986548:148987028

ENSG00000137501:SYTL2:chrll:- ENSG00000169764:UGP2:chr2:+:6 ENSG00000151743:AMNl:chrl2:-

:85422155:85422275:85420543:8542545 4069672:64069733:64069571:64083 :31867815:31867885:31862359:318

5 439 81904

ENSG00000188566 :ND0R1 :chr9 :+: 140 ENSG00000135473:PAN2:chrl2:- ENSG00000184313:MROH7:chrl:+ 110518:140110640:140110469:1401107 :56712020:56712218:56711427:567 :55144935:55145112:55144527:551 23 12871 48328

ENSG00000135390:ATP5G2:chrl2:- ENSG00000118985:ELL2:chr5:- ENSGOOOOO 186001 :LRCH3 :chr3 :+:

:54063654:54063898:54059212:5406635 :95249474:95249638:95242486:952 197585704:197585776:197581316:1

9 78705 97592293

ENSG00000048544:MRPS10:chr6:- ENSG00000166169:POLL:chrl0:-

ENSG00000139546:TARBP2:chrl2:+:5 :42181857:42181930:42179655:421 : 103345618: 103345913: 103340173:

3895843:53895968:53895245:53896810 82017 103347002

ENSG00000074657:ZNF532:chrl8: ENSG00000205937:RNPSl:chrl6:-

ENSG00000173947:PIFO:chrl:+:111890 +:56532535:56532617:56532218:56 :2317175:2317238:2314761:231805

295:111890394:111889671:111892727 532701 5

ENSG00000005801:ZNF195:chrll:

ENSG00000255152:MSH5- ENSGOOOOO 164211 : ST ARD4 :chr5 : - SAPCDl:chr6:+:31726324:31726397:31 :3382972:3383119:3381795:338377 : 110843026: 110843140: 110842077: 726070:31726542 5 110848088

ENSG00000234745:HLA-B:chr6:- ENSG00000139496:NUP58:chrl3:+

ENSG00000031823 :RANBP3 :chrl 9: - :31323943:31324219:31323369:313 :25911073:25911172:25905696:259 :5957928:5957984:5951607:5978071 24464 12773 ENSG00000006283 : CACNA1 G:chrl7 :+ ENSG00000006042:TMEM98:chrl :48695219:48695269:48694932:4869545 ENSG00000133256:PDE6B:chr4:+: 7:+:31258344:31258677:31255255: 7 661644:661730:660403:663834 31261308

ENSG00000065809:FAM107B:chrl

ENSG00000231064:RP11- 0:-

ENSG00000171475:WIPF2:chrl7:+:384 263K19.4:chrl:+: 155168193: 15516 : 14595320: 14595386: 14572514: 145

16786:38416879:38412774:38418776 8409:155166808:155169962 98360 ENSG00000196821:C6orfl06:chr6:

ENSG00000136002 : ARHGEF4 :chr2 :+: 1 ENSGOOOOO 127603 :MACF1 :chrl :+: 31785517:131785657:131704208:13179 :34614377:34614575:34574681:346 39930766:39930784:39929358:3993 6425 22401 4286

ENSG00000078618 :NRDC: chrl : - ENSGOOOOO 138468 : SENP7 : chr3 : - :52302040:52302110:52301884:5230589 ENSG00000183751:TBL3:chrl6:+: : 101117704: 101117899: 101090970: 7 2026056:2026115:2025950:2026814 101136436 ENSG00000135596 :MICAL 1 :chr6 : - ENSG00000108387:SEPT4:chrl7:- ENSGOOOOO 137941 :TTLL7:chrl : - : 109768275 : 109768432: 109767975 : 1097 :56604042:56604339:56603674:566 :84417869:84418070:84417659:844 73448 09321 64613

ENSG00000243156 :MICAL3 :chr22 : - ENSG00000167491 : GATAD2A:chr ENSG00000064999:ANKSlA:chr6: : 18310409: 18310547: 18305826: 1832458 19:+: 19612777: 19612852: 19612225 +:34950528:34950604:34949763:34 7 :19613139 950889

ENSG00000093167 :LRRFIP2 :chr3 :

ENSG00000250151 : ARPC4-

ENSG00000132591:ERALl:chrl7:+:271 :37107714:37107816:37105282:371 TTLL3 :chr3 :+:9859328:9859443 :98 84956:27185003:27183600:27185391 16514 55029:9862229 ENSG00000163354:DCST2:chrl:- ENSG00000101187 : SLC04A1 :chr2 ENSG00000104067:TlPl:chrl5:- : 154995839: 154995933: 154995733: 1549 0:+:61297731:61297927:61296440: :30011980:30012220:30011342:300 96307 61299096 12561

ENSG00000106077 : ABHD 11 :chr7 :

ENSG00000214046:SMIM7:chrl9:-

ENSG00000005448:WDR54:chr2:+:746 :73151550:73151721:73151021:731 : 16770769: 16770811 : 16758072: 167 49279:74649502:74648943:74649996 51891 70895 ENSG00000147813:NAPRT:chr8:- ENSG00000126457:PRMTl:chrl9: ENSGOOOOO 138794 : CASP6 : chr4 : - : 144659231 : 144659347: 144659012: 1446 +:50183128:50183182:50180573:50 : 110617565: 110617642: 110615856: 59438 185166 110618777

ENSG00000152214 :RIT2 :chrl8 : - ENSG00000032219:ARID4A:chrl4:

ENSG00000136280:CCM2:chr7:+:4511 :40528951:40529013:40503728:405 +:58813737:58813835:58813223:58 1348:45111471 :45109560:45112324 54038 814364

ENSGOOOOO 197119 : SLC25 A29 xhr

ENSG00000095637:SORBSl:chrl0:- ENSG00000151665 :PIGF :chr2:- 14:-

:97174250:97174619:97170534:9718171 :46815213:46815318:46808730:468 : 100761962: 100762034: 100759714:

7 19613 100765178

ENSG00000136243:NUPL2:chr7:+: ENSGOOOOO 120318 : ARAP3 :chr5 :-

ENSG00000155368:DBI:chr2:+: 120125 23236791:23236866:23236385:2323 : 141051668: 141051868: 141051547: 134:120125220:120124790:120125763 9076 141052118

ENSGOOOOO 137871 :ZNF280D xhrl

ENSG00000213199:ASIC3:chr7:+:1507 ENSG00000242808:SOX2- 5:-

48258:150748406:150748182:15074889 OT:chr3:+: 181417385: 181417671:1 :56999279:56999348:56996465:569

6 81328717:181432972 99460

ENSG00000229180:GS1-

ENSG00000156504:FAM122B:chrX:- ENSG00000163138 :P ACRGL : chr4 : 124K5.12:chr7:- : 133906172: 133906313: 133905384: 1339 +:20715054:20715162:20706437:20 :66041741:66041916:66038537:660 15850 728907 53498

ENSG00000188529:SRSF10:chrl:- ENSG00000166596:CFAP52:chrl7: ENSGOOOOO 182473 :EX0C7 :chrl7: - :24298062:24298113:24294213:2429833 +:9511435:9511536:9503500:95156 :74087223 :74087316:74085401 :740 9 25 90494

ENSG00000228315:GUSBPll:chr2

ENSG00000103351:CLUAPl:chrl6 2:-

ENSG00000172379:ARNT2:chrl5:+:80 :+:3583098:3583155:3582841:3586 :24037359:24037704:24002187:240

735177:80735366:80733719:80743220 121 47615

ENSG00000182985 :CADM1 xhrl 1 :

ENSGOOOOO 122678 :POLM:chr7 : - ENSG00000204371 :EHMT2 : chr6 : - :44113729:44114129:44113624:4411833 : 115080293: 115080377: 115069158: :31856745:31856847:31856524:318 8 115085327 57004

ENSG00000148950:IMMPlL:chrll

ENSG00000135446:CDK4:chrl2:-

ENSG00000118900:UBNl:chrl6:+:4921 :31477806:31477933:31455117:314 :58145282:58145442:58145125:581 155:4921302:4920973:4922884 82172 45957 ENSG00000156113:KCNMAl:chrl0:- ENSG00000196547:MAN2A2:chrl ENSG00000087085:ACHE:chr7:- :78673814:78673895:78669854:7867469 5:+:91453445:91453522:91452734: : 100489954: 100490439: 100488959: 3 91453730 100490785

ENSG00000133816 :MICAL2 xhrl 1 ENSGOOOOO 175606 : TMEM70 :chr8 :

ENSG00000102317:RBM3 :chrX:+:4843 :+: 12270730: 12270793 : 12262709: 1 +:74891313:74891406:74891096:74 4309:48434471:48434055:48434701 2277189 893389 ENSG00000267426:RP11- 552F3.12:chrl7:- ENSG00000112851 :ERBIN:chr5 :+: ENSG00000076685 :NT5C2 xhrlO : -

:73897281:73897354:73895755:7389779 65370851:65371058:65350779:6537 : 104860419: 104860700: 104859776: 2 2143 104860801

ENSG00000107957:SH3PXD2A:ch

ENSG00000139112:GABARAPLl:chrl rlO:- 2:+: 10367267: 10367378: 10366786: 1037 ENSG00000090316:MAEA:chr4:+: : 105382226: 105382310: 105377071: 0661 1321414:1321491:1309388:1326544 105386845 ENSG00000152128:TMEM163:chr

ENSG00000152578:GRIA4:chrll:+:105 ENSG00000270647:TAF15:chrl7:+ 2:-

836673:105836788:105816228:1058450 :34144719:34144759:34136580:341 : 135309618: 135309662: 135308232:

36 61569 135470769

ENSG00000085511 :MAP3K4:chr6:+: 16 ENSG00000116731:PRDM2:chrl:+ ENSG00000130751:NPASl:chrl9:+ 1519309:161519459:161518208:161522 : 14095612: 14095668: 14075982: 140 :47544282:47544383:47543808:475 923 99572 46067

ENSG00000144285:SCNlA:chr2:- ENSGOOOOO 148339 : SLC25A25 :chr

ENSG00000112659:CUL9:chr6:+:43154 : 166858981: 166859263: 166856286: 9:+: 130864358: 130864394: 1308636 697:43154833:43154193:43154983 166863739 75:130864648 ENSG00000186952:TMEM232:chr5:- ENSG00000137776:SLTM:chrl5:- ENSGOOOOO 177943 :MAMDC4 :chr9 : 109760523 : 109760617: 109756457: 1099 :59224554:59224642:59209198:592 :+: 139753170: 139753305: 13975299 04147 25602 8:139753660

ENSG00000070010 :UFD 1L :chr22: - ENSG00000074054:CLASPl:chr2:- ENSG00000078053:AMPH:chr7:- : 19462590 : 19462623 : 19459331 : 1946660 : 122184979: 122185006: 122182882: :38457424:38457550:38433814:384 5 122187648 62020

ENSG00000117543 :DPH5 :chrl :- ENSG00000115419:GLS:chr2:+:19 ENSG00000151150:ANK3:chrl0:- : 101490864: 101491022: 101487321: 1014 1777918:191778090:191775047:191 :61819455:61819764:61819188:618 91238 785749 22868

ENSG00000254901:BORCS8:chrl9

ENSG00000143537:ADAM15:chrl:+:15 ENSG00000078687:TNRC6C:chrl7

5033893:155033965:155032819:155034 :+:76075475:76075622:76073415:7 : 19296842: 19296907: 19293492: 193

379 6079127 02889

ENSG00000181090:EHMTl:chr9:+:140 ENSG00000174516:PELI3:chrll:+: ENSG00000169727:GPSl:chrl7:+:8

646782:140646860:140638542:1406486 66236303:66236375:66235751:6623 0010131:80010335:80009840:80011

22 8712 149

ENSG00000138035 :PNPT 1 : chr2 : - ENSG00000078674:PCMl:chr8:+:l ENSG00000163395:IGFNl:chrl:+:2

:55913504:55913579:55912183:5592079 7792214:17792367:17782289:17793 01193806:201194002:201191955:20

7 097 1194951

ENSG00000206145:P2RX6P:chr22:

ENSG00000213614 :HEXA: chrl 5 : - ENSG00000134444:KIAA1468:chr

:72645408:72645519:72643575:7264789 :21398437:21398588:21396703:213 18:+:59947006:59947089:59942706

9 99250 :59947592

ENSG00000214765 : SEPT7P2 :chr7 :

ENSG00000165714:BORCS5:chrl2

ENSG00000170579:DLGAPl:chrl8:- :45765782:45765835:45765314:457 :+: 12514139: 12514283: 12510052:1 :3879111:3880140:3814273:4005115 67776 2588561

ENSG00000058404 : CAMK2B : chr7

ENSG00000136717:BINl:chr2:-

ENSG00000166579:NDELl:chrl7:+:836 :44279187:44279262:44274275:442 : 127809830: 127809938: 127808488:

6637:8366672:8363478:8370247 80305 127816586

ENSG00000139597 :N4BP2L 1 xhrl

ENSG00000092020:PPP2R3C:chrl4:- 3:- ENSG00000095564:BTAFl:chrl0:+

:35585815:35585943:35579835:3559110 :32978339:32978408:32977337:329 :93726393:93726514:93722435:937

7 81781 40210

ENSG00000124615:MOCSl:chr6:- ENSG00000151150:ANK3:chrl0:-

ENSG00000131626:PPFIAl:chrll:+:70 :39876815:39876878:39874893:398 :61926348:61926411:61898845:619

211478:70211541:70208594:70218320 77578 26581

ENSG00000054611:TBClD22A:chr22:+ ENSGOOOOO 151092 :NGLY 1 : chr3 : - ENSG00000203761 :MST02P:chrl :

:47370185:47370295:47308084:4739352 :25761504:25761682:25761126:257 +: 155717767: 155717918: 155717687

9 70623 : 155718190

ENSG00000176393:RNPEP:chrl:+:2019 ENSG00000127990:SGCE:chr7:- ENSG00000135097:MSIl:chrl2:-

58510:201958659:201958172:20196527 :94217089:94217124:94214827:942 : 120789146: 120789203 : 120785317:

4 18000 120791101

ENSG00000150275:PCDH15:chrl0

ENSG00000166169:POLL:chrl0:-

ENSG00000118762 :PKD2 :chr4 :+: 88967 :55571308:55571379:55570424:555 : 103345618: 103345913: 103342648: 793 :88968022 :88959653: 88973142 87152 103347002

ENSG00000107864:CPEB3:chrl0:- ENSG00000135299:ANKRD6:chr6:

ENSG00000139651:ZNF740:chrl2:+:53 :93851586:93851701:93841258:938 +:90331640:90331745:90315824:90 578674:53578824:53575776:53579170 70832 333128 ENSG00000132589:FLOT2:chrl7:- ENSG00000111249:CUX2:chrl2:+: ENSGOOOOO 196781 :TLE1 :chr9: - :27212874:27212965:27211333:2721596 111742013:111742118:111736393:1 :84249011:84249216:84235472:842 2 11744724 67128

ENSG00000074054:CLASPl:chr2:- ENSG00000132781 :MUTYH:chrl :- : 122202514: 122202538: 122187753: 1222 :45795560:45795740:45795109:457 ENSG00000249141:RP11- 04912 96187 514012.4:chr6:- : 167360169: 167360227: 167356577: 167365975

ENSG00000160767 :FAM189B xhrl : - ENSG00000198563 :DDX39B :chr6 :- : 155223874: 155223985: 155223523: 1552 ENSG00000103197:TSC2:chrl6:+: :31508929:31509104:31508311:315 24190 2132436:2132505:2131799:2133695 09726

ENSG00000014641:MDHl:chr2:+: ENSG00000196792 : STRN3 :chrl4 : -

ENSG00000162341:TPCN2:chrll:+:688 63821621:63821720:63816180:6382 :31398406:31398517:31382863:314

34970:68835073:68831435:68837897 6303 04368

ENSG00000267645 :P0LR2 J2 : chr7 :

ENSG00000129197:RPAIN:chrl7:+

ENSG00000162004:CCDC78:chrl6:- : 102307536: 102307711:102306610: :5329555:5329619:5326149:533586 :774105:774205:773161:774321 102309361 1

ENSG00000172775:FAM192A:chrl

ENSG00000101337:TM9SF4:chr20: 6:-

ENSG00000175267:VWA3A:chrl6:+:22 +:30720815:30720929:30697558:30 :57212413:57212764:57207781:572

162015:22162167:22161252:22163831 729299 19942

ENSG00000082397:EPB41L3:chrl8

ENSG00000141380:SS18:chrl8:- ENSG00000125462:Clorf61:chrl:-

:23615794:23615887:23615091:2361851 : 156383875: 156384090: 156377767: :5398019:5398142:5397425:540676

8 156384445 3

ENSG00000115414:FNl:chr2:- ENSG00000134452:FBXO18:chrl0 ENSG00000001460:STPGl:chrl:- :216236831:216237098:216236738:2162 :+:5947999:5948595:5932309:5950 :24718050:24718169:24710493:247 38044 887 27808

ENSG00000054267 : ARID4B xhrl : - ENSG00000214706:IFRD2:chr3:- ENSG00000072195: SPEG:chr2 :+:2 :235323825:235323962:235318427:2353 :50326685:50326787:50326368:503 20309603:220309883:220309464:22 24207 26877 0312695

ENSG00000162613 :FUBP1 xhrl :- ENSG00000089157:RPLP0:chrl2:-

ENSG00000100083:GGAl:chr22:+:3800 :78413137:78413237:78412261:784 : 120638521 : 120638634: 120637288:

9125:38009198:38005161:38010196 14839 120638885

ENSG00000108433:GOSR2:chrl7: ENSG00000152952 :PL0D2 :chr3 :-

ENSG00000196526:AFAPl:chr4:- +:45012394:45012535:45009565:45 : 145795648: 145795711 : 145794682: :7783102:7783354:7780603 :7787920 015964 145796902 ENSG00000125503:PPPlR12C:chrl9:- ENSG00000239969 :RP11 - ENSG00000114948: AD AM23:chr2: :55624032:55624163:55614936:5562859 163E9.2:chr7:+: 102006464: 1020065 +:207474633 :207474724 :207460886 0 23:102004858:102016269 :207482302

ENSG00000067840 :PDZD4 xhrX:- ENSG00000100505:TRIM9:chrl4:- ENSG00000157045 :NTAN1 :chrl6: - : 153073796: 153074050: 153072295: 1530 :51449659:51449683:51448821:514 : 15141853: 15141956: 15141777: 151 95693 50097 49747

ENSGOOOOO 162241 : SLC25A45 xhr

ENSG00000085433:WDR47:chrl:- 11:-

ENSG00000145214:DGKQ:chr4:- : 109529144: 109529302: 109526073: :65146846 :65147032 :65144547 :651

:956559:956708:956401:956926 109538201 47337

ENSG00000170954:ZNF415:chrl9:

ENSG00000136717:BINl:chr2:-

ENSG00000174672 :BRSK2 xhrl 1 :+: 146 :53618462:53618560:53613161:536 : 127808729: 127808819: 127808488: 9027:1469093:1467137:1471816 19565 127816586

ENSG00000080822:CLDND1 :chr3 :

ENSG00000105655:ISYNAl:chrl9:- ENSG00000255571:MIR9- : 18547782: 18547915: 18547289: 1854840 :98240496:98240562:98240281:982 3HG:chrl5:+:89931731:89931812:8 8 41385 9931112:89938258

ENSG00000204469 :PRRC2 A:chr6 : ENSG00000139116:KIF21A:chrl2:-

ENSG00000103174:NAGPA:chrl6:- +:31604509:31604722:31604385:31 :39711874:39712003:39705355:397

:5078297:5078366:5078186:5078880 604818 13707

ENSG00000137700:SLC37A4:chrl

1:- ENSG00000158856:DMTN:chr8:+:

ENSG00000082397:EPB41L3:chrl8:- :118896401:118896467:118896039: 21924595 :21924670 :21924404 :2192

:5398019:5401042:5397425:5406775 118896676 5037

ENSG00000154310:TNIK:chr3:- ENSG00000126777:KTNl:chrl4:+:

ENSG00000163879:DNALIl:chrl:+:380 : 170824971 : 170824995 : 170819422: 56130672:56130759:56128330:5613

27157:38027336:38023349:38027681 170825853 7446

ENSG00000104859:CLASRP:chrl9 ENSG00000112130:RNF8:chr6:+:3

ENSG00000163738:MTHFD2L:chr4:+:7 :+:45571677:45571738:45570852:4 7348925:37349130:37336994:37358

5147141:75147267:75091111:75167413 5572323 517

ENSG00000266714 :MYO 15B : chrl ENSG00000133794:ARNTL:chrll:

ENSG00000196220 : SRGAP3 : chr3 : - 7:+:73603013:73603084:73602102: +: 13376779: 13376843: 13375995: 13 :9074333:9074436:9069814:9079746 73606246 378285 ENSG00000124104:SNX21:chr20:+ ENSGOOOOO 143033 :MTF2 xhrl :+: 9

ENSG00000196712:NFl:chrl7:+:29694 :44469086:44469097:44463755:444 3594834:93595005:93592856:93599

242:29694296:29687721:29701030 69277 259

ENSG00000163697:APBB2:chr4:- ENSG00000132670:PTPRA:chr20:+

ENSG00000149970:CNKSR2:chrX:+:21 :40844386:40844392:40832594:408 :2955860:2955887:2928670:296741

579588:21579678:21550185:21581355 92380 0

ENSG00000108953 :YWHAE:chrl7

ENSG00000117859:OSBPL9:chrl:+

ENSG00000133816:MICAL2:chrll:+:l : 1273002: 1273035: 1268352: 130334 :52221991:52222030:52215867:522 2270730:12270793:12261132:12277189 0 26361 ENSG00000174373 :RALGAPA1 :chrl4:

ENSG00000044446 :PHKA2 xhrX: - ENSGOOOOO 141582 : CBX4 xhrl 7 : -

:36169367:36169508:36159209:3619089 : 18918787: 18918817: 18915451:189 :77809444:77809495:77809194:778

3 19602 11635

ENSG00000118454:ANKRD13C:ch

ENSG00000137817:PARP6:chrl5:- rl:- ENSG00000078018 :MAP2 :chr2 :+:2 :72543185:72543298:72535040:7254354 :70736538:70736639:70728530:707 10569173:210569344:210565062:21 7 40402 0570303

ENSG00000275066: SYNRG:chrl7:

ENSG00000133114:GPALPPl:chrl3:+:

45603373:45606242:45602138:4560737 ENSG00000172785:CBWDl:chr9> :35937477:35937711:35936516:359

0 : 146101: 146158: 135030: 154708 44755 ENSG00000143374:TARS2:chrl:+: ENSG00000169682:SPNSl:chrl6:+

ENSG00000080845 :DLGAP4 :chr20 :+: 3 150469285:150469384:150464965:1 :28993221:28993377:28992936:289 5127644:35127724:35125469:35127990 50470005 93676

ENSGOOOOO 196151 : WDSUB 1 :chr2 :

ENSG00000072210 : ALDH3 A2 xhr

ENSG00000127511:SIN3B:chrl9:+:169 17:+: 19576463: 19576588: 19575269 : 160132056: 160132149: 160112886:

73694:16973790:16973370:16974490 :19578808 160136271

ENSG00000204954:C12orf73:chrl2

ENSG00000060069 : CTDP1 xhrl 8 :+

ENSG00000086666 :ZFAND6 xhrl 5 :+: 8 :77488906:77489069:77478016:775 : 104347191: 104347312: 104345408: 0390757:80390920:80352151:80412669 13651 104350408

ENSG00000108599:AKAP10:chrl7

ENSG00000112715 :VEGFA:chr6:+

ENSG00000132600 :PRMT7 :chrl6 :+:68 :43749692:43749824:43746655:437 : 19844199: 19844323: 19843162: 198 381533:68381581:68380183:68382244 52277 45138 ENSG00000077232 :DNAJC 10 : chr2 : +: 1 ENSG00000064313 :TAF2 :chr8 :- ENSG00000156873:PHKG2:chrl6: 83604271:183604436:183601113:18360 : 120757120: 120757276: 120756633: +:30762869:30762924:30762538:30 5025 120758944 764552

ENSG00000147548:NSD3:chr8:- ENSG00000242808:SOX2- ENSG00000177192:PUSl:chrl2:+:l

:38156961:38157108:38153470:3816210 OT:chr3:+: 181417385: 181417671:1 32423717:132423820:132416857:13

4 81328717:181457356 2425836

ENSG00000158773:USFl:chrl:- ENSG00000141504 : SAT2 : chrl 7 : - ENSG00000114416:FXR1 :chr3 :+: 1 : 161011623: 161011636: 161011201: 1610 :7530260:7530362:7529932:753046 80693100: 180693192: 180686042:18 11905 0 0693909

ENSG00000175279:CENPS:chrl:+: ENSG00000276234:TADA2A:chrl

ENSG00000167555:ZNF528:chrl9:+:52 10494713 : 10494747: 10490625 : 1050 7:+:35804797:35804870:35800763:

905681:52905798:52905281:52909159 0403 35818625

ENSG00000092096:SLC22A17:chrl4:- ENSG00000124831 :LRRFIP1 :chr2: ENSG00000149577:SIDT2:chrll:+:

:23817369:23817515:23816940:2381848 +:238622901:238622919:23861727 117057705 : 117057717: 117057352: 1

0 3:238626404 17058093

ENSG00000061273 :HD AC7:chrl2 :

ENSG00000163939 :PBRM1 :chr3 :- ENSG00000084234:APLP2:chrll:+ : 52588739:52588895:52584833: 5259578 :48189688:48189799:48189550:481 : 130007150: 130007186: 130005610: 2 90799 130010292

ENSGOOOOO 110066 :KMT5B xhrl 1 :

ENSG00000189056 :RELN:chr7 :- ENSG00000100889:PCK2:chrl4:+:

: 103118835: 103118971: 103113355: 1031 24572368:24572464:24572099:2457 :67946936:67947004:67942650:679

23319 2718 47598

ENSG00000111832:RWDDl:chr6:+:116 ENSG00000125447:GGA3:chrl7:- ENSG00000092529:CAPN3:chrl5:

894020:116894148:116892818:1168952 :73239143:73239247:73238992:732 +:42698123 :42698141 :42695975:42

20 39527 700408

ENSG00000091129:NRCAM:chr7:- ENSG00000081189 :MEF2C:chr5 : - ENSG00000160613:PCSK7:chrll> : 107808721 : 107808847: 107807518: 1078 :88057085:88057145:88056942:881 : 117096646: 117096737: 117095471 : 16874 00414 117098931 ENSG00000101665:SMAD7:chrl8:

ENSG00000143416 : SELENBP 1 : chr 1 : - ENSG00000185158 :LRRC37B :chrl : 151341917: 151342030: 151340795: 1513 7:+:30354787:30354859:30351801: :46468850:46468925:46448280:464 42188 30361928 76181

ENSG00000183597:TANG02:chr2 ENSG00000135124:P2RX4:chrl2:+

ENSG00000128739:SNRPN:chrl5:+:25 2:+:20040959:20041074:20040107: : 121661060: 121661237: 121660846: 166303 :25166402:25165271 :25207260 20050860 121666335

ENSG00000175662:TOMlL2:chrl7

ENSG00000148019:CEP78:chr9:+:8

ENSG00000133256:PDE6B:chr4:+:6500 : 17764789: 17764865: 17752173 : 177 0880774:80880822:80880459:80881 33:650081:649795:650662 69609 357 ENSG00000205643:CDPFl:chr22:- ENSG00000113742:CPEB4:chr5:+: ENSG00000143256:PFDN2:chrl:- : 46643006 :46643118 :46641135: 4664406 173370028:173370052:173359503:1 : 161071837: 161071961: 161070649: 8 73371969 161087741

ENSG00000075914:EXOSC7:chr3: ENSGOOOOO 124193: SRSF6: chr20 : +:

ENSG00000167703:SLC43A2:chrl7:- +:45031041:45031136:45017826:45 42087792:42088060:42087149:4208 : 1519855: 1519924: 1518328: 1531008 038578 8410

ENSG00000214176:PLEKHMlPl:c hrl7:- ENSG00000124222:STX16:chr20:+

ENSG00000204580:DDRl:chr6:+:30852 :62810980:62811363:62801218:628 :57234678:57234690:57227194:572 314:30852487:30850760:30856464 17884 42545 ENSG00000272752: STAG3L5P- PVRIG2P- ENSG00000149532:CPSF7:chrll:- ENSG00000160050:CCDC28B:chrl

PILRB:chr7:+:99952765:99952863:9995 :61187941:61188045:61183991:611 :+:32669786:32669980:32669646:3

0746:99955842 88861 2670198

ENSGOOOOO 166762 : CATSPER2 : chr

ENSG00000138942 :RNF 185 : chr22 : 15:-

ENSG00000126457 :PRMT1 :chrl 9 :+: 50 +:31592921:31592976:31556289:31 :43939247:43939316:43932694:439 183128:50183182:50180573:50183743 597483 39491

ENSG00000083535:PIBFl:chrl3:+: ENSGOOOOO 109381 :ELF2 :chr4: -

ENSG00000163719:MTMR14:chr3:+:97 73547728:73547813:73539542:7357 : 140046317: 140046483 : 139994721 :

19667:9719742:9719071:9724861 2959 140058783

ENSG00000227053 :RP11-

ENSG00000130958:SLC35D2:chr9:- 395B7.4:chr7:-

:99098998:99099066:99086451:9912674 : 100658478: 100658548: 100657720: ENSG00000130731:METTL26:chrl

5 100660695 6:-:685280:685340:684797:685611

ENSG00000241343:RPL36A:chrX: ENSG00000169992:NLGN2:chrl7:

ENSG00000123349:PFDN5:chrl2:+:536 +:100647037: 100647083 : 10064681 +:7315475:7315526:7312031:73176

90237:53690335:53689423:53691633 0:100650322 62

ENSG00000148481:MINDY3:chrl0

ENSG00000112851 :ERBIN:chr5 :+:

ENSG00000204387:C6orf48:chr6:+:318 65367996:65368119:65364848:6537 : 15858833: 15858914: 15838171: 159

04071:31804294:31803228:31805012 0851 02204

ENSG00000067840 :PDZD4 :chrX: - ENSG00000104728:ARHGEF10:ch

ENSG00000188290:HES4:chrl:- : 153073814: 153074050: 153072295: r8:+: 1791518: 1791602: 1772279: 180 :935071:935167:934993:935245 153095693 6125 ENSG00000135250:SRPK2:chr7:- ENSG00000166012:TAFlD:chrll:- ENSG00000275832:ARHGAP23:ch : 104909252: 104909316: 104844232: 1050 :93466515:93466563:93463878:934 rl7:+:36654655:36654752:3665406 29094 67790 8:36656838

ENSG00000205758:CRYZLl:chr21

ENSG00000141994:DUS3L:chrl9:-

ENSG00000073008:PVR:chrl9:+:45162 :5786759:5786930:5786553:578707 :35013484:35013611:35003863:350

009:45162168:45157286:45164558 1 13986

ENSG00000048162:NOP16:chr5:- ENSG00000101489:CELF4:chrl8:-

ENSG00000008277 : AD AM22 :chr7 :+:87 : 175813840: 175813927: 175812328: :34839083:34839227:34833901:348 808249:87808444:87800876:87810819 175815235 44636

ENSG00000147010:SH3KBPl:chrX

ENSG00000213995:NAXD:chrl3:+:lll ENSG00000186868:MAPT:chrl7:+: 279785 : 111279894: 111267994: 1112868 44046530:44046665:44039836:4404 : 19705734: 19705809: 19702146: 197 91 9224 13729

ENSG00000122203 :KIAA1191 :chr ENSG00000005801 :ZNF195 :chrl 1 :

ENSG00000171307:ZDHHC16:chrl0:+: 5:-

99213555:99213603:99213420:9921447 : 175786483 : 175786570 : 175779751 : :3382972:3383119:3381795:339220

0 175788604 4

ENSG00000157796:WDR19:chr4:+

ENSG00000164877 :MIC ALL2 : chr7 : - :39196163:39196279:39191401:392 ENSG00000095637:SORBSl:chrl0: : 1473845 : 1474783 : 1468427: 1476377 01097 :97131082:97131184:97127456:971 31740

ENSG00000146067 :FAM193B :chr5 : - ENSG00000166398:KIAA0355:chr ENSG00000119979:FAM45A:chrl0 : 176959443 : 176959642: 176952206: 1769 19:+:34791659:34791873:34790828 :+: 120864275: 120864534: 12086370 81249 :34810811 9:120864822

ENSG00000151789 :ZNF385D :chr3 : - ENSG00000137992:DBT:chrl:- :21553113:21553249:21552515:2160606 ENSG00000169598:DFFB:chrl:+:3 : 100696288: 100696470: 100684303 :

5 789577:3789701:3789136:3800070 100700991

ENSG00000133519 :ZDHHC8P 1 : chr22 : - ENSG00000158863:FAM160B2:chr ENSG00000010282:HHATL:chr3:- :23736112:23736244:23733911:2374194 8:+:21947271:21947365:21946809: :42741249:42741317:42740637:427

6 21951950 44108

ENSG00000079819:EPB41L2:chr6:

ENSG00000196872 :KIAA1211L :chr2 :- ENSG00000140365:COMMD4:chrl : 99449324:99449460:99448975: 9945458 : 131199243: 131199390: 131184858: 5:+:75630402:75630479:75628433: 1 131206235 75630695

ENSGOOOOO 198739:LRRTM3 :chrlO

ENSG00000172824:CES4A:chrl6:+:670 ENSG00000178950:GAK:chr4:- :+:68686678:68688210:68686345:6 38695:67038776:67038127:67042876 :906522:906582:898567:907394 8857344 ENSG00000090097:PCBP4:chr3:- ENSG00000156976:EIF4A2:chr3:+: ENSG00000028203:VEZT:chrl2:+: :51995956:51996104:51995320:5200134 186506098:186506209:186505671:1 95692637:95692719:95690034:9569 1 86506913 3940

ENSG00000187391:MAGI2:chr7> ENSG00000133627 : ACTR3B :chr7 : ENSG00000143995:MEISl:chr2:+:

:77764337:77764523:77762377:7778934 +:152550578: 152550662: 15252220 66796181:66796277:66795888:6679

1 7:152551542 8377

ENSGOOOOO 186625 :KATNAl:chr6:

ENSG00000150764:DIXDCl:chrll:+:ll ENSG00000108387:SEPT4:chrl7:-

1844746:111844978:111839362:111851 :56608840:56608912:56603674:566 : 149922729: 149922935: 149919486:

461 09321 149924403

ENSG00000148840:PPRCl:chrl0:+ ENSGOOOOO 186654 :PRR5 :chr22:+:

ENSG00000197498:RPF2:chr6:+:11132 : 103904776: 103904847: 103904064: 45127609:45127701:45122514:4513

0913:111320990:111312989:111329240 103906428 2651

ENSG00000048991 :R3HDM1 :chr2 : ENSG00000198089:SFIl:chr22:+:3

ENSG00000058600:POLR3E:chrl6:+:22 +: 136373721: 136373763: 13636258 1976257:31976350:31974438:31979

343380:22343506:22337599:22344964 6:136374237 860

ENSG00000109339:MAPK10:chr4:

ENSG00000152147:GEMIN6:chr2:

ENSG00000102312:PORCN:chrX:+:483 +:39006399:39006583:39006260:39 :87010358:87010430:86989108:870

72514:48372529:48371240:48372627 008658 22204

ENSG00000134313 :KIDINS220:chr ENSG00000154065:ANKRD29:chr

ENSG00000005810:MYCBP2:chrl3:- 2:- 18:- :77677343 :77677445 :77673148:7769247 :8887274:8887331:8877129:888801 :21192055:21192154:21181273:211 4 6 97695

ENSG00000073921 :PICALM:chrl 1

ENSG00000143434:SEMA6C:chrl:- ENSG00000178691:SUZ12:chrl7:+ : 151110791: 151110882: 151110581: 1511 :85701292:85701442:85695016:857 :30274635:30274704:30267505:302 11105 07868 93165

ENSG00000116991 : SIPAlL2:chrl :- ENSGOOOOO 164620 :RELL2 :chr5 :+:

ENSG00000224078:SNHG14:chrl5:+:2 :232539870:232539924:232539317: 141018521:141018588:141018427:1

5488573:25488704:25487263:25489086 232561334 41019030

ENSG00000168016:TRANKl:chr3:

ENSG00000171723:GPHN:chrl4:+:

ENSG00000133256:PDE6B:chr4:+:6497 :36915616:36915787:36905971:369 67309395:67309434:67291284:6734 28:649795:648677:650033 31319 6656 ENSG00000143157 :POGK:chrl :+: 1668 ENSG00000186642:PDE2A:chrll:- ENSG00000117153 :KLHL12:chrl:- 15848:166815975:166810325:16681673 :72342121 :72342183:72319795:723 :202864649:202864845:202863877: 0 85180 202878137

ENSG00000159409:CELF3:chrl:- ENSG00000141644:MBDl:chrl8:- ENSG00000198520:Clorf228:chrl: : 151679620: 151679770: 151679210: 1516 :47800555 :47800720:47800233 :478 +:45163734:45163901:45155546:45 79982 01498 166594

ENSG00000088387 :DOCK9 :chrl 3 :- ENSG00000163697:APBB2:chr4:- ENSGOOOOO 182796 :TMEM198B:ch

:99460893:99460929:99460061:9946160 :41145003:41145159:41102767:412 rl2:+:56225040:56225133:5622486

5 16421 7:56226742

ENSG00000173898 : SPTBN2 :chrl 1 :

ENSG00000142227:EMP3:chrl9:+:

ENSG00000158806 :NPM2 :chr8 :+:21882 :66488820:66488911:66488733:664 48830777:48830818:48830179:4883 726:21882817:21881768:21882946 96211 2608 ENSGOOOOO 197622 : CD C42 SE 1 : chr

ENSG00000179912:R3HDM2:chrl2:- 1:- ENSG00000109689:STIM2:chr4:+:

:57686354:57686450:57677839:5768918 : 151029131:151029262: 151028469: 27022622:27022690:27019606:2702

1 151031954 4140

ENSG00000085224:ATRX:chrX:- ENSG00000124222:STX16:chr20:+

ENSG00000144677 :CTDSPL :chr3 :+: 37 :76849165:76849319:76845410:768 :57234678:57234690:57227143:572 988547:37988702:37903769:38006061 54879 48686

ENSG00000114982:KANSL3:chr2:

ENSG00000169919:GUSB:chr7:- ENSG00000134278:SPIREl:chrl8:-

:65444820:65444898:65444528:6544521 : 97272706 : 97272784 : 97271248 : 972 : 12459753 : 12459927: 12454482: 124

0 74244 63349

ENSG00000260565:ERVK13- l:chrl6:- ENSG00000163531:NFASC:chrl:+:

ENSG00000142875:PRKACB:chrl:+:84 :2719411:2719562:2713408:272134 204919684:204919702:204913534:2 639011:84639035:84630105:84644859 5 04921138 ENSG00000164815:ORC5:chr7:- ENSG00000255717:SNHG1 :chrl 1 :- ENSG00000120438:TCPl:chr6:- : 103824390: 103824481: 103808973: 1038 :62621489:62621536:62621305:626 : 160208774: 160208903 : 160205099: 28698 21990 160210436

ENSG00000067840 :PDZD4 xhrX:-

ENSG00000196208:GREBl:chr2:+:1175 ENSG00000214021 :TTLL3 :chr3 :+: : 153073351:153073594: 153072824: 2620:11752736:11751153:11755216 9860238:9860604:9855029:9862229 153073796 ENSG00000139631:CSAD:chrl2:- ENSG00000133961:NUMB:chrl4:- : 53564960:53565225:53564286: 5356566 :73783097:73783130:73763993:737 ENSG00000125841 :NRSN2 : chr20 :

5 89837 +:330281:330476:330007:333853

ENSG00000157087:ATP2B2:chr3:- ENSG00000144214:LYGl:chr2:- ENSG00000138758:SEPTll:chr4:+: : 10373594: 10373721: 10370809: 1037781 :99908998:99909103:99907884:999 77957922:77957990:77952123 :7796 2 12090 0895

ENSG00000140105:WARS:chrl4:- ENSG00000132676:DAP3 xhrl :+: 1 ENSG00000028203:VEZT:chrl2:+: : 100841619: 100841740: 100835595: 1008 55695172:155695202:155691409:15 95650929:95651015:95650398:9565 42596 5695782 6681

ENSG00000249141:RP11-

514012.4:chr6:- ENSG00000117114: ADGRL2:chrl : ENSG00000126777:KTNl:chrl4:+:

: 167362057: 167362113: 167356577: 1673 +:82446478:82446523:82445644:82 56139889:56139973:56139730:5614 65975 447491 2552

ENSG00000184381:PLA2G6:chr22:

ENSG00000139323:POClB:chrl2:- ENSG00000130751 :NPAS 1 xhrl 9 :+

:89853792:89853815:89853495:8986054 :47544235:47544383:47543808:475 :38521645:38521698:38519265:385

6 46067 22377

ENSG00000257621 :PSMA3 - ASlxhrU:- ENSG00000142185:TRPM2:chr21:

ENSG00000103034:NDRG4:chrl6:+:58 :58752308:58752474:58740728:587 +:45846892:45846994:45846619:45 544548:58544587:58543256:58545325 58352 855013 ENSG00000091129:NRCAM:chr7:- ENSG00000171914:TLN2:chrl5:+: ENSG00000148187:MRRF:chr9:+:l : 107808721 : 107808847: 107800937: 1078 63014551:63014686:63012079:6301 25033231:125033354:125027217:12 15766 7174 5042721

ENSG00000141644:MBDl:chrl8:- ENSG00000110921 :MVK:chrl2:+: ENSG00000145390:USP53:chr4:+:l

:47797838:47797910:47796188:4779904 110016969:110017087:110013950:1 20189422:120189575:120188637:12

6 10017606 0190845

ENSG00000133657:ATP13A3:chr3:

ENSGOOOOOO 12660 :ELO VL5 : chr6 : -

ENSG00000187953:PMS2CL:chr7:+:67 :53138017:53138142:53135525:531 : 194132927: 194133017: 194126845:

73029:6773158:6771586:6774935 39887 194146070

ENSG00000122085:MTERF4:chr2:

ENSG00000100376:FAM118A:chr22:+: ENSG00000137411:VARS2:chr6:+:

45731230:45731263:45728591:4573626 :242038810:242039309:242029459: 30890158:30890331:30890018:3089

6 242041667 0482

ENSG00000137261 :KI AA0319 :chr6 : - ENSG00000124356:STAMBP:chr2: ENSGOOOOO 139624 :CERS5 :chrl2 :- :24554768:24554859:24551753:2455683 +:74056531:74056637:74056197:74 :50526744:50526847:50524477:505 4 057971 28328

ENSG00000145725 :PPIP5K2 :chr5 :+: 10 ENSG00000106603 :C0A1 :chr7:- ENSG00000164615:CAMLG:chr5:+ 2523014:102523077:102520445:102526 :43688198:43688251:43680248:437 : 134079676: 134079742: 134077213: 542 69027 134086448

ENSG00000130477:UNC13A:chrl9

ENSGOOOOO 118197 :DDX59 : chrl : -

ENSG00000110536:PTPMT1 :chrl 1 :+:4 :200619552:200619804:200618354: : 17727216:17727273 : 17722664: 177 7591251:47591443:47587538:47593022 200628154 28510 ENSG00000043143 :JADE2:chr5:+: 1339 ENSG00000105402:NAPA:chrl9:- ENSG00000078549:ADCYAPlRl:c 12457:133912586:133909452:13391418 :48006679:48006759:47998853 :480 hr7:+:31135280:31135364:3113234 6 18099 9:31139740

ENSG00000043143 :JADE2:chr5:+: 1339 ENSG00000117143 :UAP1 xhrl :+:l ENSG00000136854:STXBPl:chr9:+ 12457:133912586:133909452:13391418 62562521 : 162562572: 162560301 : 16 : 130446646: 130446772: 130444839:

3 2567581 130453053

ENSG00000047346:FAM214A:chrl5:- ENSG00000133641:C12orf29:chrl2 ENSG00000015592: STMN4 :chr8 : -

:52879252:52879416:52877141:5288577 :+:88433924:88434042:88429515:8 :27099193:27099274:27098779:270

4 8436601 99913

ENSG00000150433:TMEM218:chrll:- ENSG00000078018:MAP2:chr2:+:2 ENSG00000154265 : ABCA5 :chrl7:- : 124972027 : 124972247: 124971199: 1249 10557348:210561074:210545551:21 :67247887 :67248007 :67246762:672 72532 0565000 49713

ENSG00000063245:EPNl:chrl9:+: ENSGOOOOO 132781 :MUTYH:chrl : -

ENSG00000151490:PTPRO:chrl2:+:157 56200662:56200737:56200360:5620 :45798589:45798631 :45798506:457

13126:15713210:15710457:15718526 1232 98768

ENSG00000247774:PCED1B-

ASl:chrl2:- ENSG00000160781 :P AQR6 : chrl : - ENSG00000163879:DNALIl:chrl:+

:47604422:47604544:47603241:4760994 : 156214932: 156215029: 156214702: :38024927:38025097:38023349:380

7 156215325 27681

ENSG00000177990:DPY19L2:chrl

2:- ENSG00000213625:LEPROT:chrl:

ENSG00000145362:ANK2:chr4:+: 11429 :63974441:63974616:63964637:639 +:65895613:65895731:65891061:65 5919:114296102: 114294605 : 114302612 76185 897485

ENSG00000198520:Clorf228:chrl: ENSG00000140157:NIPA2:chrl5:-

ENSG00000157557:ETS2:chr21:+:4017 +:45190210:45190340:45190064:45 :23027800:23027922:23021429:230

8374:40178732:40178044:40181958 190433 34146

ENSG00000066933 :MY09 Axhrl 5 :

ENSG00000134644 :PUM1 xhrl :- ENSG00000110074 :FOXRED 1 xhr :31414768:31414970:31414119:3141819 11:+: 126144821: 126144916: 126143 :72139755:72139809:72122652:721 2 349:126145221 41185

ENSG00000079974:RABL2B:chr22

ENSG00000140678:ITGAX:chrl6:

ENSG00000142949:PTPRF:chrl:+:4406 +:31382654:31382818:31382535:31 :51207882:51207980:51207552:512

3418:44063724:44058272:44064390 382950 14199

ENSG00000169255:B3GALNTl:ch

ENSG00000079277:MKNK1 xhrl :- r3:- ENSG00000228327:RP11- :47051545 :47051646:47049001 :4705190 : 160807731 : 160807850: 160804576: 206L10.2:chrl:-

5 160821214 :704876:705092:703993:708355

ENSG00000148481 :MINDY3 xhrlO

ENSG00000088543 :C3orfl8:chr3 :- ENSG00000114956:DGUOK:chr2:+

:50602896:50603292:50598495:5060489 : 15858833: 15858914: 15838171: 158 :74177753:74177859:74154179:741

3 75628 85272

ENSG00000148950:IMMPlL:chrll

ENSG00000187109:NAPlLl:chrl2:- ENSG00000090905:TNRC6A:chrl6

:76467982:76468019:76454059:7647834 :+:24816025:24816172:24815640:2 :31484718:31484852:31455117:315

6 4816334 31065

ENSG00000076351 :SLC46A1 xhrl

ENSG00000104529:EEFlD:chr8:- 7:- ENSGOOOOO 112078 :KCTD20 :chr6: : 144671160: 144672262: 144669022: 1446 :26729255:26729339:26727783:267 +:36442565:36442839:36410888:36 79517 31633 446897

ENSG00000025772:TOMM34:chr2

ENSG00000135502:SLC26A10:chrl2:+: 0:-

58016569:58016717:58016424:5801864 ENSG00000070404:FSTL3:chrl9:+ :43577370:43577518:43572220:435

8 :680273:680489:676526:681332 80473

ENSG00000111832:RWDDl:chr6:+:116 ENSG00000069849: ATP1B3 :chr3 :+ ENSG00000153944:MSI2:chrl7:+:5

894020:116894148:116892818:1169014 : 141635396: 141635416: 141634862: 5754347:55754420:55752487:55756

57 141640818 909

ENSG00000242073:AC006014.7:ch ENSG00000076864:RAPlGAP:chrl

ENSG00000123815:COQ8B:chrl9:- r7:-

:41209619:41209760:41209527:4121100 :75113474:75113533:75104454:751 :21930150:21930405:21929406:219

0 15140 32558

ENSG00000133243:BTBD2:chrl9:- ENSG00000132581:SDF2:chrl7:-

ENSG00000084774:CAD:chr2:+:274634 : 1991875: 1992055: 1990821: 199301 :26978503 :26978595 :26976294:269

34:27463485:27463229:27463778 8 82304

ENSG00000077238:IL4R:chrl6:+:2 ENSG00000157796:WDR19:chr4:+:

ENSG00000135740:SLC9A5:chrl6:+:67 7372086:27372136:27370315:27373 39191275:39191401:39188224:3920

291433:67291504:67291337:67292220 572 5261 ENSG00000108599:AKAP10:chrl7 ENSG00000204248: COL 11 A2 :chr6

ENSG00000145428:RNF175:chr4:-

:154669796:154669938:154644610:1546 : 19835117: 19835291: 19827830: 198 :33153477:33153555:33148947:331

72589 39598 54403

ENSG00000224924 :LINC00320 :chr

ENSG00000143515:ATP8B2:chrl:+:154 21:- ENSG00000213160:KLHL23:chr2:

313012:154313019:154310020:1543133 :22154567:22154764:22153979:221 +: 170591522: 170592737: 170554041

29 75312 : 170597894

ENSG00000197444:OGDHL:chrl0:

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000104325:DECRl:chr8:+: : 131190702: 131191266: 131188721: 1312 91031136:91031194:91013789:9103 :50945831:50945904:50944566:509 06235 3136 45992

ENSG00000235098:ANKRD65:chr

1:- ENSG00000105865:DUS4L:chr7:+:

ENSG00000162065:TBClD24:chrl6:+:2 : 1355431:1355972: 1354929: 135617 107205032: 107205121 : 107204654: 1

549357:2549421:2547114:2549835 6 07207494

ENSG00000168385:SEPT2:chr2:+:2422 ENSG00000169762 : T APT 1 : chr4 : - ENSG00000159082:SYNJl:chr21:-

56913:242257014:242255025:24226363 : 16172275: 16172352: 16168416: 161 :34048641:34048665:34045841:340

0 75826 50954

ENSG00000135365:PHF21A:chrll:

ENSG00000170633:RNF34:chrl2:+:121 ENSG00000177879:AP3Sl:chr5:+:

855663:121855714:121838021:1218580 115230783:115230855:115205825:1 :45967626:45967649:45959863:459

44 15249058 70436

ENSG00000107263:RAPGEFl:chr9

ENSG00000255857:PXN- ENSG00000136717:BINl:chr2:-

AS1 :chrl2:+: 120644347: 120644515 : 120 : 127809830: 127809938: 127808488: : 134494437: 134494596: 134480575:

639229:120647641 127815048 134497182

ENSG00000081154:PCNP:chr3:+:l ENSG00000120156:TEK:chr9:+:27

ENSG00000110011 :DNAJC4:chrl 1 :+:6 01298432:101298848:101293123:10 192486:27192621: 27185627:271973 4000172:64000337:63999436:64001365 1311470 12 ENSG00000164077:MONlA:chr3:- ENSG00000168484:SFTPC:chr8:+: ENSG00000135502:SLC26A10:chr :49948958:49949444:49948317:4995065 22019288:22019383:22017368:2202 12:+:58019364:58019470:58019247 2 0086 :58019780

ENSG00000182199:SHMT2:chrl2: ENSG00000019144:PHLDBl:chrll

ENSG00000087274:ADDl:chr4:+:29283 +:57625263: 57625343 :57624783 :57 :+: 118512971: 118513112: 11850971

68:2928402:2927839:2929897 625495 9:118514517

ENSG00000110931 :CAMKK2:chrl

ENSG00000144406:UNC80:chr2:+:2108 2:- ENSG00000139974:SLC38A6:chrl

02252:210802354:210800532:21080419 : 121682375: 121682418: 121678672: 4:+:61519066:61519703:61518853:

5 121682942 61545527

ENSG00000135749 :PCNX2 :chrl :- ENSG00000120948:TARDBP:chrl:

ENSG00000002016:RAD52:chrl2:- :233160891:233161145:233152900: +: 11084358: 11084392: 11082307: 11 : 1035961: 1036112: 1034691: 1036310 233190013 085166 ENSG00000170085 :SIMCl:chr5 :+: 1757 ENSG00000137166:FOXP4:chr6:+: ENSG00000025423:HSD17B6:chrl 16656: 175717958: 175665640: 17572203 41545723:41545819:41533702:4155 2:+:57179685:57179798:57178800: 2 2506 57180908

ENSG00000140522:RLBPl:chrl5:- ENSG00000136628:EPRS:chrl:- ENSG00000226174:TEX22:chrl4:+

:89761795:89761924:89760555:8976219 :220191467:220191488:220184398: : 105915695: 105915746: 105911848:

4 220191790 105916394

ENSG00000166169:POLL:chrl0:- ENSG00000138111 :MFSD 13 A:chr ENSGOOOOO 172995 : ARPP21 :chr3 :+ : 103345618: 103345913: 103344676: 1033 10:+: 104225738: 104225844: 104221 :35758789:35758849:35756968:357 47002 207:104228711 63096

ENSG00000146147:MLIP:chr6:+:5 ENSG00000171703:TCEA2:chr20:+

ENSG00000026950:BTN3Al:chr6:+:26 4095511:54095715:54067031:54122 :62695244:62695302:62694737:626 410121:26410142:26409961:26410233 105 97828 ENSG00000138101:DTNB:chr2:- ENSG00000175287:PHYHDl:chr9: ENSG00000171634:BPTF:chrl7:+: :25642383 :25642404:25611230:2565575 +: 131702647: 131702776: 13170022 65882243:65882432:65871860:6588

4 3:131703723 7959

ENSG00000006432:MAP3K9:chrl4

ENSG00000204257:HL A-DMA:chr6 : - ENSG00000162910:MRPL55:chrl:- :32920060:32920238:32918580:3292072 :228296137:228296722:228295570: :71202677:71202746:71201215:712

5 228296849 04961

ENSG00000163539: CL ASP2 : chr3 : - ENSG00000081026:MAGI3:chrl:+: ENSG00000065243 :PKN2 :chrl :+: 8 :33618693:33618756:33617767:3362331 114224833 :114224924:114223958:1 9270073:89270217:89251896:89270 2 14225518 528 ENSG00000107263 :RAPGEF 1 : chr9 : - ENSG00000160410:SHKBPl:chrl9 ENSG00000137312:FLOTl:chr6:- : 134479347: 134479440: 134477536: 1344 :+:41089506:41089623:41086842:4 :30709438:30709481:30709110:307 97182 1092679 09568

ENSG00000256646:RP11- lllK18.1:chr7:- ENSG00000168256:NKIRAS2:chrl ENSG00000144642:RBMS3:chr3:+:

:42966981:42967058:42964396:4297171 7:+:40174582:40174658:40174490: 28798248:28798459:28617987:2879

6 40175671 8599

ENSG00000106327:TFR2:chr7:- ENSG00000101203 :COL20A1 :chr2 ENSG00000163872:YEATS2:chr3: : 100225529: 100225597: 100225443 : 1002 0:+:61953409:61953463:61952451: +: 183521043: 183521123: 183519316 25846 61958103 :183521774

ENSG00000204387 : C6orf48 :chr6:+ ENSG00000170791:CHCHD7:chr8:

ENSG00000073614:KDM5A:chrl2:- :31804075:31804294:31803228:318 +:57125320:57125448:57124396:57

:395291:395373:394828:401924 05012 127156

ENSG00000187239:FNBPl:chr9:- ENSG00000017260:ATP2Cl:chr3:+

ENSG00000179104:TMTC2:chrl2:+:83 : 132678244: 132678259: 132671278: : 130613551:130613619: 130613181:

250788:83251359:83081448:83289596 132687238 130649259

ENSG00000136840:ST6GALNAC4

ENSG00000101901 :ALG13 :chrX:+: 110 ENSG00000118162:KPTN:chrl9:- :chr9:- 960180:110960232:110956525:1109610 :47986758:47986841:47986472:479 : 130678686: 130678773: 130677120: 73 87191 130679104

ENSG00000106077 : ABHD 11 :chr7 :- ENSG00000143643 :TTC13 :chrl :- ENSG00000154134:R0B03 :chrl 1 : :73152205:73152472:73152065:7315265 :231075131 :231075242:231069607: +: 124747832: 124748027: 124747554

7 231076185 : 124748479

ENSG00000081760:AACS:chrl2:+:1256 ENSG00000016864 : GLT8D 1 :chr3 :- ENSG00000147140:NONO:chrX:+: 09250: 125609315: 125603311: 12561270 :52738739:52738968:52734512:527 70504246:70504303 :70503571 :7051 6 39462 0478

ENSG00000071054:MAP4K4:chr2:+:10 ENSG00000112234:FBXL4:chr6:- ENSG00000124831 :LRRFIP1 :chr2: 2480282 : 102480513 : 102477448 : 102481 :99365249:99365595:99353546:993 +:238647874:238647952:238629465 391 74352 :238657006

ENSG00000168890:TMEM150A:ch

ENSG00000151640:DPYSL4:chrl0:+:13 ENSG00000136754:ABIl:chrl0:- r2:- 4005872:134006024:134004339:134006 :27052808:27052889:27040712:270 :85828428:85828605:85828230:858 161 54146 29006

ENSG00000141837:CACNAlA:chr

ENSG00000107521:HPSl:chrl0:- ENSG00000177479:ARIH2:chr3:+: 19:- : 100195028: 100195171: 100193848: 1001 48964894:48965246:48956431 :4898 : 13340895: 13341023: 13335586: 133 95391 2568 42523

ENSG00000100410 :PHF5 A: chr22 : - ENSG00000185189:NRBP2:chr8:- ENSG00000140367:UBE2Q2:chrl5 :41864023:41864151:41863618:4186460 : 144917989: 144918045: 144917900: :+:76170301:76170362:76165909:7

5 144918296 6171438

ENSG00000105402:NAPA:chrl9:- ENSG00000147044:CASK:chrX:- ENSG00000106772 :PRUNE2 :chr9 : -

:48003889:48004006:47998853:4801809 :41416284:41416353:41414888:414 :79234255:79234303:79229516:792

9 19031 44107

ENSG00000015475 :BID :chr22: - ENSG00000052723 : SIKE1 :chrl : - ENSG00000183889:AC138969.4:ch : 18226568: 18226779: 18222254: 1825714 : 115321552: 115321675: 115319080: rl6:+: 16429717: 16429994: 1642774

6 115321762 1:16434162

ENSGOOOOO 110076 :NRXN2 :chrl 1 :- ENSG00000135596:MICALl:chr6:- ENSG00000142920:AZIN2:chrl:+: :64390224:64390550:64387844:6439787 : 109772802: 109772903 : 109767975 : 33560148:33560314:33547109:3356

3 109773448 2307

ENSGOOOOO 104419 :NDRG1 :chr8 :- ENSG00000101811:CSTF2:chrX:+: : 134292474: 134292510: 134276895: 1343 100085796:100085856:100083091:1 ENSG00000167842:MIS12:chrl7:+: 09376 00086503 5391515:5391909:5390004:5392142

ENSG00000256525:POLG2:chrl7:- ENSG00000044115: CTNNA1 : chr5 : ENSG00000213398:LCAT:chrl6:-

:62479035:62479091:62476506:6248184 +: 138216730: 138216826: 13816340 :67974639:67974734:67974381:679

4 7:138221900 76265

ENSG00000043093 :DCUNlDl:chr

ENSG00000173540:GMPPB:chr3:- 3:- ENSG00000166734:CASC4:chrl5:+

:49759663:49759791:49759580:4976002 : 182683466: 182683541: 182681837: :44695084:44695252:44673174:447

8 182698274 05533

ENSG00000004399 :PLXND l:chr3:- ENSG00000103671:TRIP4:chrl5:+: ENSG00000113971 :NPHP3 : chr3 : - : 129302409: 129302512: 129297276: 1293 64706283 :64706410 :64702027 :6471 : 132418196: 132418294: 132416206: 04794 0739 132418761

ENSG00000205236:RP11-

ENSG00000130477:UNC13A:chrl9:- 514P8.6:chr7:- : 17734350: 17734356: 17732679: 1773563 ENSG00000106346:USP42:chr7:+: : 102246304: 102246434: 102242852: 7 6199080:6199124:6196686:6200185 102249207 ENSG00000205581:HMGNl:chr21:

ENSG00000177879:AP3Sl:chr5:+:

ENSG00000061656:SPAG4:chr20:+:342 115242517:115242558:115238689:1 :40717755:40717884:40717200:407 06844 : 34206920 : 34206642 : 34207116 15249058 19304 ENSG00000138674 : SEC31 A:chr4 : - ENSG00000113716:HMGXB3:chr5 ENSG00000138028:CGREFl:chr2:- :83782783:83782861:83778917:8378368 :+: 149386035: 149386210: 14938455 :27325227:27325298:27325089:273 6 2:149391817 25393

ENSG00000167106:FAM102A:chr9

ENSG00000110076 :NRXN2 :chrl 1 ENSG00000151500:THYNl:chrll:-

:64444485:64444509:64436076:6445311 : 130710349: 130710504: 130708032: : 134118702: 134118853: 134118378:

7 130742270 134119060

ENSG00000188002:RP11-

ENSG00000135299:ANKRD6:chr6: 43F13.1:chr5>

ENSG00000164190 :NIPBL : chr5 : +: 3703 +:90321990:90322089:90315824:90 : 1632758: 1632866: 1629745 : 163295 8703:37038840:37027514:37044448 333128 9

ENSG00000095637:SORBSl:chrl0:

ENSG00000114859:CLCN2:chr3:-

ENSG00000088854 :C20orfl 94:chr20 : - : 184071329: 184071583: 184071210: : 97096277 :97097051 :97082562 : 970 :3285086:3285190:3277596:3295679 184071888 98889

ENSG00000177943:MAMDC4:chr9 ENSG00000188878:FBFl:chrl7:-

ENSG00000171735:CAMTAl:chrl:+:75 :+: 139752637: 139752728: 13975254 :73916087:73916188:73915955:739

27889:7527961:7309686:7700459 9:139752851 16354

ENSG00000229180:GS1-

ENSG00000138028:CGREFl:chr2:- 124K5.12:chr7:-

ENSG00000235944:ZNF815P:chr7:+:58 :27333540:27333836:27327245:273 :66041741:66041916:66038537:660 79579:5879706:5873199:5880320 41713 57243 ENSG00000151474:FRMD4A:chrl0:- ENSG00000128563:PRKRIPl:chr7: ENSG00000139428:MMAB:chrl2:- : 13693902: 13693974: 13689035: 1369641 +:102006420: 102006523 : 10200485 : 109999047: 109999134: 109998909: 5 8:102016269 109999584

ENSG00000142687 :KIAA0319L :chrl :- ENSG00000137312:FLOTl:chr6:- ENSG00000237441 :RGL2 :chr6 :- :35972212:35972736:35944813:3601995 :30709390:30709481:30709110:307 :33262464:33262539:33261843:332 0 09923 62753

ENSG00000124786:SLC35B3:chr6:

ENSG00000142330:CAPN10:chr2:+:241 ENSG00000183889:AC138969.4:ch

536097:241536359:241534721:2415373 rl6:+: 16429908: 16429994: 1642774 :8417634:8417727:8417228:841981

04 1:16434162 2

ENSG00000176261:ZBTB80S:chrl

ENSG00000076685 :NT5C2 :chrlO : - ENSG00000148498:PARD3:chrl0:- : 104871501 : 104871562: 104866463 : 1048 :33100302:33100393:33097480:331 :34663801:34663930:34649187:346 99162 16033 66894

ENSG00000273018:CTD-

ENSG00000204653:ASPDH:chrl9:- ENSG00000140905:GCSH:chrl6:- 2303H24.2:chrl7:- :51016183:51016268:51015837:5101774 :81118067:81118139:81116568:811 :18427090:18427191:18422988:184 7 21205 35819

ENSG00000172889:EGFL7:chr9:+:1395 ENSG00000028203:VEZT:chrl2:+: ENSG00000154814:OXNADl:chr3:

64057:139564173:139563125:13956436 95650925:95651015:95645847:9566 +: 16313651:16313828: 16313229: 16

5 0132 327848

ENSG00000080822:CLDND1 :chr3 :

ENSG00000203875 : SNHG5 :chr6 :- ENSG00000162600:OMA1 :chrl :-

:86387512:86387593:86387210:8638785 :98240496:98240562:98240286:982 :58996272:58996401:58993007:589

3 41692 99624

ENSG00000005379:TSPOAPl:chrl

ENSG00000196440 : ARMCX4 :chrX:+: 1 7:- 00766011 : 100766042: 100764665 : 10077 :56397469:56397490:56396655:563 ENSG00000127419:TMEM175:chr 9190 97891 4:+:941496:941680:926328:944208

ENSG00000135407:AVIL:chrl2:- ENSGOOOOO 141504 : SAT2 : chrl 7 : - ENSG00000099251 :HSD 17B7P2 :ch :58201113:58201510:58200322:5820197 :7530260:7530362:7530111:753046 rl0:+:38658051:38658156:3865455

6 0 7:38658880

ENSGOOOOO 160781 :P AQR6 : chrl : - ENSG00000114841 :DNAH1 :chr3 :+

ENSG00000204227:RINGl:chr6:+:3317 : 156216471: 156216547: 156216041: :52432047:52432178:52431893:524

8934:33179324:33176677:33179505 156217747 32865

ENSG00000105552:BCAT2:chrl9:- ENSG00000145362:ANK2:chr4:+:l

ENSG00000156860:FBRS:chrl6:+:3067 :49310256:49310331:49303554:493 14269431 : 114269464: 114267178: 11 8862:30678943:30674180:30679880 14240 4271383 ENSG00000150433:TMEM218:chrll:- ENSG00000067066:SP100:chr2:+:2 : 124972027 : 124972247: 124971199: 1249 ENSG00000229180:GS1- 31314275:231314425:231313865:23 72629 124K5.12:chr7:- 1325976 :66053498:66053567:66038537:660

57243

ENSG00000198216:CACNAlE:chrl:+:l ENSGOOOOO 177380 :PPFIA3 :chrl 9 : ENSG00000106772 :PRUNE2 :chr9 : -

81762800:181762929:181759692:18176 +:49649422:49649449:49649262:49 :79234255:79234303:79229516:792

3999 651339 51386

ENSG00000136643:RPS6KCl:chrl:+:21 ENSG00000198952:SMG5:chrl:- ENSG00000006194 :ZNF263 :chrl6:

3349742:213349835:213341316:213403 : 156236297: 156236469: 156236171: +:3335058:3335239:3334205:33360

839 156237260 22

ENSG00000071889:FAM3A:chrX:- ENSG00000136895:GARNL3:chr9: ENSG00000169398:PTK2:chr8:- : 153736141: 153736213: 153735821: 1537 +: 130126867: 130127055: 13011965 : 141780814: 141780898: 141774389: 36619 6:130127578 141799572

ENSG00000073921 :PICALM:chrl 1 : - ENSG00000174437:ATP2A2:chrl2: ENSG00000089022:MAPKAPK5:c :85701292:85701442:85693046:8570786 +: 110785197: 110785258: 11078412 hrl2:+: 112306556: 112306665: 1123 8 6:110788096 05473:112308888

ENSG00000120860:WASHC3:chrl2:- ENSG00000204580:DDRl:chr6:+:3 ENSG00000168958:MFF:chr2:+:22 : 102443966: 102444069: 102439897 : 1024 0853401:30853457:30851922:30856 8207460:228207535:228205096:228 55025 464 211941

ENSG00000245958:RP11- ENSG00000087495 :PHACTR3 :chr ENSG00000124313 :IQSEC2 :chrX: - 33Bl.l:chr4:+: 120418965: 120419058: 12 20:+:58342240:58342450:58330419 :53264964:53265014:53264366:532 0415678:120433505 :58381095 65503

ENSG00000164418 : GRIK2 : chr6 : +: 1025 ENSG00000245958:RP11- ENSG00000122085:MTERF4:chr2:- 11836: 102511923 : 102503455: 10251622 33B1.1 :chr4:+: 120464907: 1204650 :242033691:242033847:242029459: 1 00:120449944:120471533 242041667

ENSGOOOOO 135424 : ITGA7 :chrl 2 : - ENSG00000143815:LBR:chrl:-

ENSG00000170525:PFKFB3:chrl0:+:62 :56094045:56094177:56092701:560 :225597992:225598118:225594534:

73225:6273277:6270181:6274857 94682 225599038

ENSG00000181790:ADGRBl:chr8: ENSG00000197971:MBP:chrl8:-

ENSG00000197586:ENTPD6:chr20:+:2 +: 143558474: 143558639: 14355805 :74700450:74700476:74692427:747

5187714:25188033:25176503:25190484 6:143558745 28787

ENSG00000178761:FAM219B:chrl

5:- ENSG00000138658:ZGRFl:chr4:-

ENSG00000103154:NECAB2:chrl6:+:8 :75197322:75197400:75197053:751 : 113469408: 113469536: 113468564:

4014443:84014469:84012157:84014634 98618 113474990

ENSG00000021645 :NRXN3 :chrl4 : ENSG00000119979:FAM45A:chrl0

ENSG00000163138 :PACRGL:chr4:+:20 +:80271454:80271533:80164280:80 :+: 120864275: 120864534: 12086370 709425 :20709493 :20706437:20728907 327381 9:120867479

ENSG00000170464:DNAJC18:chr5

ENSG00000118454:ANKRD13C:chrl:- ENSG00000206149:HERC2P9:chrl

:70771906:70771973:70766591:7079053 5:+:28863669:28863801:28863524: : 138758396: 138758506: 138749961:

5 28874411 138760693

ENSG00000148660: CAMK2G:chrl

ENSG00000105705:SUGPl:chrl9:- ENSG00000115977:AAKl:chr2:- 0:- : 19414532: 19414852: 19414257: 1941665 :69706082:69706193:69704122:697 :75585078:75585105:75581488:755 7 09842 97225

ENSGOOOOOH4956:DGUOK:chr2: ENSGOOOOO 187609:EXD3 :chr9 :-

ENSG00000140650:PMM2:chrl6:+:890 +:74184251:74184367:74174033:74 : 140259578: 140260608: 140250820:

4935:8905035:8900264:8905494 185272 140260944

ENSG00000135749 :PCNX2 :chrl :- ENSG00000115896 :PLCLl:chr2:+:

ENSG00000099840:IZUM04:chrl9:+:2 :233362971:233363117:233344435: 198948481 :198950956: 198670063: 1

097927:2097954:2097494:2098285 233372590 98953581

ENSG00000275778:PRH1-

ENSG00000169727:GPSl:chrl7:+: PRR4:chrl2:-

ENSG00000142875:PRKACB:chrl:+:84 80010250:80010335:80009840:8001 : 11126253:11126320:11001006: 113

639011:84639035:84630696:84640715 1149 24020

ENSG00000069849:ATPlB3:chr3:+:141 ENSG00000171051:FPRl:chrl9:- ENSG00000178691:SUZ12:chrl7:+

620977:141621069:141595752:1416224 :52253455:52253506:52250258:522 :30274635:30274704:30264539:302

61 55066 93165

ENSG00000133316:WDR74:chrll:

ENSG00000111731:C2CD5:chrl2:- ENSG00000135541:AHIl:chr6:- :22655672:22655738:22646271:2265964 :62601089:62601146:62600603:626 : 135816676: 135816847: 135813429: 4 01263 135818720

ENSG00000043514 :TRIT1 :chrl : - ENSG00000149179:Cllorf49:chrll

ENSG00000131626:PPFIAl:chrll:+:70 :40315790:40315933:40313769:403 :+:47008758:47008861:46958402:4 197099:70197129: 70196145:70200406 19641 7073938 ENSG00000100505:TRIM9:chrl4:- ENSGOOOOO 117481 :NSUN4 :chrl :+: :51467400:51467558:51448821:5147579 ENSG00000230084:RP4- 46812592:46812747:46810816:4681 7 613B23.1:chr3:- 8539 :42674120:42674187:42665304:426

95485

ENSG00000082458:DLG3:chrX:+:6 ENSGOOOOO 198815 :F0XJ3 xhrl : -

ENSG00000166833:NAV2:chrll:+:2007 9713225:69713325:69712446:69715 :42730785:42730860:42693637:427

1381:20071447:20070741:20072834 257 76720

ENSGOOOOO 160741 : CRTC2 : chrl : - ENSG00000153310:FAM49B:chr8:-

ENSG00000186470 :BTN3A2:chr6:+:26 : 153921590: 153921860: 153920805: : 130891634: 130891717: 130883742: 373124:26373325:26370831 :26373503 153924493 130915557

ENSG00000183386:FHL3:chrl:- ENSGOOOOO 198075 : SULT1C4 :chr2 :

ENSG00000197343:ZNF655:chr7:+:991 :38464928:38465104:38464820:384 +: 108999548: 108999675: 108998343

60810:99160889:99160117:99161485 71028 : 108999871

ENSG00000075043:KCNQ2:chr20:

ENSG00000026652 : AGPAT4 :chr6 :- ENSG00000119946:CNNMl:chrl0: : 161575180: 161575342: 161574531:1615 :62043127:62043235:62039889:620 +: 101147576: 101147760: 101136975 87279 44802 : 101150062

ENSG00000157800:SLC37A3:chr7:

ENSG00000068305 :MEF2A:chrl5 :+: 10 ENSG00000231064:RP11- 0138634:100138716:100105874:100173 : 140043211:140043363: 140037149: 263K19.4:chrl:+: 155169962: 155170 182 140045668 102:155168409:155170490

ENSG00000110455 :ACCS:chrll:+: ENSG00000138796:HADH:chr4:+:

ENSG00000204624 :DISP3 :chrl :+: 11591 44104973:44105127:44104861:4410 108948843 : 108949225 : 108944719: 1 621:11591767:11586892:11594437 5244 08954331 ENSG00000108651 :UTP6 :chrl7: - ENSG00000141556:TBCD:chrl7:+: ENSG00000135749:PCNX2:chrl:- :30193673:30193734:30192457:3019506 80858526:80858607:80851508:8086 :233397790:233397911:233397067: 4 9633 233398703

ENSG00000256500 :RP11 - ENSG00000135502:SLC26A10:chr

ENSG00000159023:EPB41:chrl:+:2938 73M18.2:chrl4:+: 104037959: 10403 12:+:58018282:58018389:58016424

5100:29385157:29379824:29386933 8157:104029461:104053610 :58018648

ENSG00000100523:DDHDl:chrl4:

ENSG00000175193:PARL:chr3:-

ENSG00000196220 : SRGAP3 : chr3 : - : 183551511:183551613: 183551377: :53518561:53518645:53513667:535 :9069783:9069814:9068679:9079746 183558357 21155 ENSG00000058404 :CAMK2B :chr7 : - ENSG00000204256:BRD2:chr6:+:3 ENSG00000078328:RBFOXl:chrl6 :44323729:44323824:44302663:4436495 2942797:32942889:32942542:32943 :+:7680604:7680685:7657340:7703

5 160 816

ENSG00000184967 :NOC4L :chrl2:+: 13 ENSG00000231925 : TAPBP : chr6 : - ENSG00000174516:PELI3:chrll:+: 2631825:132631933:132630210:132635 :33275881 :33275935:33273164:332 66236303:66236375:66234498:6623 525 80993 8712

ENSG00000204152 :TIMM23B xhrl ENSG00000161692:DBF4B:chrl7:+

ENSG00000178467:P4HTM:chr3:+:490 0:+:51372578:51372702:51371646: : 42825708:42825833:42824883 :428

43209:49043300:49040029:49044119 51374369 27962

ENSG00000107263 :RAPGEF1 :chr9

ENSG00000102606:ARHGEF7:chrl3:+: ENSG00000186648:CARMIL3:chrl

111862218:111862349:111857720:1118 : 134480317: 134480575: 134477536: 4:+:24534830:24534959:24534482:

70025 134497182 24535606

ENSG00000168067:MAP4K2:chrll

ENSG00000197965 :MPZL 1 :chrl :+: 1677 ENSG00000183963:SMTN:chr22:+: 42472: 167742605 : 167734986: 16775705 :64568371:64568503:64568298:645 31495050:31495165:31494826:3149

6 68582 5730

ENSG00000283196:RP4-

614C10.2:chr2:- ENSG00000110422 :HIPK3 xhrl 1 :+ ENSG00000138688:KIAA1109:chr

:91842945:91843023:91816979:9184339 :33307958:33309057:33279435:333 4:+: 123247009: 123247072: 1232464

3 50055 75:123249258

ENSG00000146232:NFKBIE:chr6:- ENSGOOOOO 165487 :MICU2 xhrl 3 : -

ENSG00000197283:SYNGAPl:chr6:+:3 :44230296:44230399:44228276:442 :22089672:22089699:22088557:220

3410229:33410271:33409536:33410665 32718 95383

ENSG00000136436:CALCOC02:chrl7: ENSG00000091140:DLD:chr7:+:10 ENSGOOOOO 160218 : TRAPPC 10 : chr

+:46933940:46933978:46933549:469376 7542182:107542262:107533723:107 21:+:45511803:45511930:45509814

75 543922 :45513943

ENSG00000105662:CRTCl:chrl9: ENSG00000055609:KMT2C:chr7:-

ENSGOOOOO 132600 :PRMT7 :chrl6 :+:68 +: 18882251:18882356: 18876338: 18 : 151892991: 151893096: 151891653: 345944:68346079:68345002:68349799 886450 151896363 ENSG00000100600:LGMN:chrl4:- ENSG00000089847 : ANKRD24 xhr ENSG00000006695:COX10:chrl7:+ :93172827:93172998:93170706:9317601 19:+:4207497:4207604:4207309:42 : 14095305: 14095538: 14063264: 141 6 08760 10126 ENSG00000244026:FAM86DP:chr3:- ENSG00000141446:ESC01:chrl8:- ENSG00000135063 :FAM189 A2 xhr

:75479982:75480065:75475750:7548195 : 19120537: 19120661: 19119970: 191 9:+:72001474:72002599:72000863:

8 40819 72003073

ENSG00000137700 : SLC37 A4 :chrl 1 ENSG00000155508:CNOT8:chr5:+: ENSG00000140105:WARS:chrl4:- : 118897280: 118897398: 118896790: 1188 154242766:154242955:154238328:1 : 100841619: 100841743: 100835595: 97646 54244751 100842596

ENSG00000067113 :PLPP1 :chr5 :- ENSG00000144320:LNPK:chr2:-

ENSG00000244242 :IFITM10 :chrl 1 : - :54786787:54786942:54771278:548 : 176856958: 176857146: 176844596: : 1770244: 1770356: 1769349: 1771588 30399 176860285 ENSG00000138078:PREPL:chr2:- ENSG00000089159:PXN:chrl2:- ENSG00000091157:WDR7:chrl8:+: :44548965:44549039:44548584:4454986 : 120653362: 120653464: 120653076: 54444012:54444111:54426184:5444 9 120659425 6661

ENSG00000095485:CWF19Ll:chrl0:- ENSG00000076382:SPAG5:chrl7:- ENSG00000149970:CNKSR2:chrX: : 102016018: 102016233: 102013296: 1020 :26911669:26911763:26911498:269 +:21534602:21534749:21519706:21 27327 12119 544984

ENSG00000156709:AIFMl:chrX:- ENSG00000144935:TRPCl:chr3:+:

ENSG00000055813:CCDC85A:chr2:+:5 : 129289130: 129289261: 129283543: 142496473 : 142496605 : 142467302: 1

6602950:56603070:56570090:56611400 129290434 42521010

ENSG00000214548:MEG3:chrl4:+: ENSG00000183960 :KCNH8 :chr3 :+:

ENSG00000093000:NUP50:chr22:+:455 101300968:101301088:101298978:1 19295145:19295379:19190287:1932

74118:45574781:45567564:45577166 01302503 2689

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000244219:GS1- ENSG00000141314:RHBDL3:chrl7

1702647:131702776:131698924:131703 259H13.2:chr7:+:99205295:992054 :+:30615810:30616035:30593319:3

723 33:99204517:99208015 0621312

ENSG00000143776:CDC42BPA:ch rl:-

ENSG00000102385:DRP2:chrX:+: 10051 :227198578:227198764:227192812: ENSG00000082805:ERCl:chrl2:+:

0172:100510238:100509550:100511106 227203780 1313666:1313678:1299218:1345934

ENSG00000120685:PROSERl:chrl3:- ENSG00000156219:ART3:chr4:+:7 ENSG00000122367:LDB3:chrl0:+:

:39597188:39597267:39591681:3959860 7025089:77025122:77022172:77033 88446825:88447029:88441560:8845

9 538 1652

ENSG00000228903 :RASA4CP:chr7

ENSG00000149532:CPSF7:chrll:-

ENSG00000078674 :PCM1 :chr8 :+: 17797 :44076270:44076408:44073910:440 :61187393:61187566:61183991:611 550:17797667:17797370:17804694 78405 88861

ENSG00000119487 :MAPKAP1 xhr 9:- ENSGOOOOO 177943 :MAMDC4 :chr9

ENSG00000189157 :FAM47E:chr4 :+:77 : 128434678: 128434922: 128432186: :+: 139753456: 139753584: 13975299 201416:77201494:77192921:77204533 128469249 8:139753660 ENSG00000188185 :LINC00265 :chr7 :+: ENSG00000160285:LSS:chr21:- ENSG00000144674:GOLGA4:chr3: 39828080:39828203:39822398:3982895 :47616115:47616181:47615670:476 +:37402733:37402796:37396678:37 2 25749 407570

ENSG00000255036:RP11- ENSG00000113231:PDE8B:chr5:+: ENSGOOOOO 156313 :RPGR:chrX:-

23 J9.4:chr9:+: 100080744: 100080864: 10 76649170:76649231:76640756:7669 :38138419:38138458:38136025:381

0079510:100082407 6072 46346

ENSG00000100266:PACSIN2:chr2

ENSG00000133318:RTN3:chrll:+: 2:-

ENSG00000223959:AFG3LlP:chrl6:+:9 63472322:63472379:63449250:6348 :43272893:43273016:43272339:432

0045217:90045286:90044210:90046649 1442 75053

ENSG00000087076:HSD17B14:chr

ENSG00000143393:PI4KB:chrl:- 19:-

ENSG00000213593:TMX2:chrll:+:575 : 151298647: 151298849: 151297393: :49335922:49336009:49318398:493

05307:57505498:57505140:57505825 151299746 37532

ENSGOOOOO 174353 : STAG3L3 :chr7

ENSG00000150656:CNDPl:chrl8:

ENSG00000125991:ERGIC3:chr20:+:34 +:72228090:72228253 :72226707:72 :72470880 :72471004 :72470382 :724

142142:34142157:34136618:34142814 229281 73543

ENSG00000136933:RABEPK:chr9:+:12 ENSG00000119979:FAM45A:chrl0 ENSG00000176444:CLK2:chrl:-

7975648:127975801:127970000:127982 :+: 120864822: 120865007 : 12086370 : 155235650: 155235745: 155234565:

817 9:120867459 155237800

ENSG00000162650:ATXN7L2:chrl:+:l ENSG00000163013:FBX041:chr2:- ENSG00000104529:EEFlD:chr8:- 10031004: 110031087: 110030426: 11003 :73490805:73490958:73490436:734 : 144672777: 144672905: 144672251 : 1468 91065 144674816

ENSG00000168385:SEPT2:chr2:+:2422 ENSG00000187416:LHFPL3:chr7:+ ENSG00000198825:INPP5F:chrl0:

56913:242257014:242255955:24226363 : 104485828: 104485876: 104377358: +: 121551028: 121551157: 121541283

0 104546633 : 121551380 ENSG00000099998:GGT5:chr22:- ENSG00000175182:FAM131A:chr3

ENSG00000068796:KIF2A:chr5:+:6166 :24622043:24622234:24621620:246 :+: 184055098: 184055159: 18405391 8264:61668378:61662308:61669513 22598 1:184059511 ENSG00000100266:PACSIN2:chr22:- ENSG00000010244 :ZNF207:chrl7 : ENSG00000181458:TMEM45A:chr :43276622:43276628:43275175:4327818 +:30688486:30688534:30687986:30 3 :+: 100277248: 100277433 : 1002117 9 689932 72:100287665

ENSG00000189367:KIAA0408:chr

ENSG00000138399:FASTKDl:chr2> 6:- ENSG00000106976:DNMl:chr9:+:l

: 170394522: 170394651:170393850: 1703 : 127772426: 127772462: 127771497 : 30988313:130988365:130985139:13 96560 127774991 0996299

ENSG00000188130:MAPK12:chr22

ENSG00000121753:ADGRB2:chrl:- ENSG00000169592:IN080E:chrl6:

:32200783:32200882:32198744:3220118 :50695510:50695622:50695075:506 +:30015888:30015978:30012851:30

0 96671 016541

ENSG00000058404 : CAMK2B : chr7

ENSG00000115561 :CHMP3:chr2:- ENSG00000106665:CLIP2:chr7:+:7 :86769374:86769435:86756520:8679042 :44279187 :44279262:44260500 :442 3787261:73787366:73774608:73790 6 80305 216

ENSG00000180329:CCDC43:chrl7

ENSG00000136891:TEX10:chr9:-

ENSG00000131584 : ACAP3 xhrl :- :42757952:42758011:42756411 :427 : 103070781 : 103070963 : 103066124: : 1230097 : 1230196: 1230008: 1230826 59370 103072580 ENSG00000275993 : CH507- ENSG00000174938:SEZ6L2:chrl6: 42P11.8:chr21:-

:44839738:44839885:44839358:4484011 :29906579:29906781:29900046:299 ENSG00000130731:METTL26:chrl

3 08142 6:-:685611:685774:685340:686093

ENSG00000165138:ANKS6:chr9:- ENSG00000068745:IP6K2:chr3:- ENSG00000110851:PRDM4:chrl2:- : 101552385: 101552888: 101547158: 1015 :48732126:48732257:48731673 :487 : 108145423: 108145986: 108140201: 58414 32522 108147700

ENSG00000095066:HOOK2:chrl9:

ENSG00000089159:PXN:chrl2:-

ENSG00000006194 :ZNF263 : chrl 6 :+: 33 : 120657009: 120657894: 120653076: : 12876642: 12876648: 12876538: 128 35058:3335239:3334205:3339392 120659425 76740 ENSG00000064787 :BCAS 1 :chr20: - ENSG00000147144:CCDC120:chr ENSG00000059915:PSD:chrl0:- :52583444:52583612:52574036:5260182 X:+:48922566:48922629:48922195: : 104178457: 104178516: 104176878: 5 48922984 104179837

ENSG00000130177:CDC16:chrl3:+:115 ENSG00000197586:ENTPD6:chr20 ENSGOOOOO 143393 :PI4KB : chrl : - 002119 : 115002174 : 115000607 : 1150022 :+:25201867:25201969:25199250:2 : 151282686: 151282731:151280277: 73 5203473 151298647

ENSG00000092421:SEMA6A:chr5:

ENSG00000171204:TMEM126B:ch

ENSG00000172785:CBWDl:chr9:- :115808580:115808631 :115803443 : rll:+:85342730:85342852:8533973 : 146101: 146158: 135030: 152033 115808768 2:85345129

ENSG00000204387 : C6orf48 : chr6 :+ :

ENSG00000106829:TLE4:chr9:+:82227 ENSG00000182903:ZNF721:chr4:- 31803187:31803228:31802977:3180

570:82227633:82191092:82242288 :438131:438221:432421:466363 5012

ENSG00000175182:FAM131A:chr3:+:l ENSG00000131773 :KHDRBS3 xhr ENSG00000204469:PRRC2A:chr6:

84056174:184056317:184053911:18405 8:+: 136657301: 136657360: 1366192 +:31602908:31603049:31602754:31

9511 80:136659235 603170

ENSG00000112983 :BRD8:chr5 :- ENSG00000131051:RBM39:chr20:-

ENSG00000119729:RHOQ:chr2:+:4680 : 137495243: 137495288: 137492956: :34301623:34301779:34301018:343

3225:46803390:46770951:46808066 137495757 02106

ENSG00000205771 :CATSPER2P1 :

ENSG00000171189:GRIKl:chr21:- chrl5:- ENSGOOOOO 198818: SFT2D 1 :chr6 : -

:30968845:30968890:30963545:3097114 :44036348:44036417:44029206:440 : 166744872: 166744895: 166743735:

9 36592 166755906

ENSG00000112186:CAP2:chr6:+:l ENSG00000123106:CCDC91:chrl2

ENSG00000180488:MIGAl:chrl:+:7832 7507871 : 17507957: 17507543 : 17539 :+:28408513:28408595:28343574:2 5724:78325811 :78324741 :78326908 499 8410134 ENSG00000054282:SDCCAG8:chrl:+:2 ENSG00000105649:RAB3A:chrl9:- 43456700:243456796:243456521:24346 : 18313322: 18313665: 18311255: 183 ENSG00000197530:MIB2:chrl:+:l 8014 14705 560937:1561033:1560808:1562029

ENSG00000184271:POU6Fl:chrl2:- ENSG00000114268 :PFKFB4:chr3:- ENSG00000141030:COPS3:chrl7:- :51590581:51590729:51589956:5159155 :48576686:48576743:48576052:485 : 17179348: 17179497: 17174322: 171 2 77129 84445 ENSG00000198208 :RPS6KL 1 xhrl 4:- ENSGOOOOO 114867 :EIF4G1 :chr3 :+:

ENSG00000175634:RPS6KB2:chrll:+:6 :75375803:75375893:75375635:753 184033859:184034006:184033644:1

7199826:67199963:67198986:67200070 77950 84035108

ENSG00000224924 :LINC00320 :chr

ENSG00000076555:ACACB:chrl2:+:10 21:- ENSG00000088298:EDEM2:chr20:-

9685410:109685508:109684253:109687 :22150960:22151080:22150865:221 :33725682:33725808:33714178:337

788 53666 30175

ENSG00000258472:RP11- ENSG00000123562 :MORF4L2 xhr

192H23.4:chrl7:- X:- ENSG00000149294:NCAM1 xhrl 1 :

:26940279:26940363 :26932233 :2694045 : 102933426: 102933528: 102931979: +: 113111507: 113111555: 113107037 7 102940098 : 113126598

ENSG00000118985 :ELL2 :chr5 : - ENSG00000141376:BCAS3:chrl7: ENSG00000162066:AMDHD2:chrl :95255127:95255249:95242486:9527870 +:59457866:59457932:59445855:59 6:+:2577561:2577616:2571124:257 5 469337 7773

ENSG00000105655:ISYNAl:chrl9:

ENSGOOOOO 122678 :POLM:chr7 : - ENSG00000143164:DCAF6:chrl:+:

:44113729:44114129:44113624:4411610 :18547493 : 18547687: 18547289:185 168007608:168007726: 167974031: 1

7 48408 68012262

ENSG00000110931:CAMKK2 xhrl

ENSG00000122085:MTERF4:chr2:- ENSG00000102125:TAZ:chrX:+:15 2:-

:242035807:242035853:242029459:2420 3647881:153648085:153642527:153 : 121682375: 121682418: 121678345:

36657 648370 121682942

ENSG00000132541:RIDA:chr8:- ENSG00000203875 : SNHG5 :chr6 :- ENSG00000146453:PNLDCl:chr6:

:99120873:99120941:99118554:9912925 :86387512:86387593:86387210:863 +: 160239977: 160240153: 160239686

9 87671 : 160240285

ENSG00000160284:SPATClL:chr2

1:- ENSG00000260537:RP11-

ENSG00000085733 :CTTN:chrl 1 :+:7026 :47602537:47603688:47588572:476 529K1.3 :chrl6:+:70346511:7034656 8614:70268737:70266616:70269045 04269 0:70333257:70348804 ENSG00000102078:SLC25A14:chrX:+: ENSG00000137965:IFI44:chrl:+:79 129483797: 129483841 : 129483319: 1294 ENSG00000127419:TMEM175:chr 116225:79116337:79115590:791199 84619 4 :+: 942298 : 942403 :941942 :944208 27 ENSG00000147996:CBWD5:chr9:- ENSG00000106070:GRB10:chr7:-

ENSG00000090857:PDPR:chrl6:+:7016 :70472571 :70472659:70467530:704 :50799968:50800065:50771605:508 4325:70164447:70163025:70165204 73436 23583 ENSG00000078549:ADCYAPlRl:chr7: ENSG00000146574:CCZlB:chr7:- ENSG00000157734:SNX22:chrl5:+ +:31139740:31139824:31132349:311461 :6844568:6844686:6841154:685439 :64444441:64444525:64444049:644 09 4 44836

ENSG00000124831 :LRRFIP1 :chr2:+:23 ENSG00000106772 :PRUNE2 : chr9 : - ENSG00000141504:SAT2:chrl7:- 8659842:238659914:238657967:238661 :79239367:79239406:79229516:792 :7530680:7530732:7529932:753087 951 44107 4

ENSG00000185774 :KCNIP4 :chr4 : - ENSG00000172508:CARNSl:chrll ENSG00000240771 : ARHGEF25 xh :20884230:20884332:20852290:2195019 :+:67186226:67186714:67183673:6 rl2:+:58007798:58007902:5800754

3 7186957 3:58008113

ENSG00000125744:RTN2:chrl9:- ENSG00000072134 :EPN2 :chrl7:+:

ENSG00000183077 : AFMID :chrl7 :+:76 :45996417:45996636:45992811:459 19188932:19189103:19187027:1921 198783:76198832:76187141:76202991 97423 3197 ENSG00000158106:RHPNl:chr8:+:1444 ENSG00000275832:ARHGAP23:ch ENSGOOOOO 182979 :MTA1 :chrl4 :+: 61998:144462155:144461678:14446275 rl7:+:36655173:36655196:3665475 105934674:105934686:105933079:1 8 2:36656838 05935803

ENSG00000156113:KCNMAl:chrl0:- ENSG00000109920:FNBP4:chrll:- ENSGOOOOO 111218 :PRMT8 xhrl 2 :

:78644746:78644775:78637648:7864704 :47747288:47747388:47746330:477 +:3678642:3678730:3662880:36860

8 52925 36

ENSG00000031823 :RANBP3 xhrl 9

ENSG00000127952 : STYXL 1 :chr7 :- :75643059:75643205:75634722:7565116 :5957928:5957984:5933490:597807 ENSG00000185615:PDIA2:chrl6:+: 8 1 335311:335433:335015:335505

ENSG00000143850:PLEKHA6:chr

ENSG00000229809:ZNF688:chrl6:- 1:- ENSG00000115459:ELMOD3:chr2:

:30582330:30582444:30581757:3058275 :204224753 :204224807 :204219742 : +:85590219:85590289:85589383:85

4 204225929 595808

ENSG00000091972:CD200:chr3:+:1120 ENSG00000117016:RIMS3 xhrl :- ENSG00000125970:RALY:chr20:+: 59748: 112059830: 112052071: 11206640 :41113339:41113514:41101729:411 32661624:32661672:32661441:3266 4 31065 3679 ENSG00000047346:FAM214A:chrl

ENSG00000063241:ISOC2:chrl9:- 5:- ENSG00000071462:WBSCR22:chr : 55966626:55966697:55964755: 5596771 :52892323:52892432:52885933:528 7:+:73098096:73098231:73098003 : 5 93282 73100965

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000185246:PRPF39:chrl4: ENSG00000108231:LGIl:chrl0:+:9 : 131190951:131191266: 131184858: 1312 +:45565626:45565961:45565431 :45 5553650:95553918:95553107:95556 06235 566089 724

ENSGOOOOO 112159 :MDN1 :chr6 : - ENSG00000198216:CACNAlE:chr ENSG00000173540:GMPPB:chr3:-

:90372510:90372686:90371958:9037420 1:+: 181745236: 181745364: 1817413 :49760028:49760187:49759580:497

5 67:181752814 60404

ENSG00000280670:CCDC163:chrl

ENSG00000135541:AHIl:chr6:- ENSG00000239521:GATS:chr7:- : 135607536: 135607686: 135606785: 1356 :99810669:99810756:99800226:998 :45961089:45961217:45960838:459 21637 21192 62227

ENSG00000111196 :MAGOHB xhr

ENSG00000100711:ZFYVE21:chrl4:+: 12:- ENSGOOOOO 129187 :DCTD :chr4 :-

104196129:104196183:104195320:1041 : 10761696: 10761982: 10760535: 107 : 183837571: 183837692: 183836728:

98956 62429 183838440

ENSGOOOOO 108061 : SH0C2 xhrlO :+: 112 ENSG00000104177 :MYEF2 : chr 15 : - ENSG00000162148:PPPlR32:chrll

723882:112724819:112679415:1127453 :48444430:48444481:48444139:484 :+:61253995:61254082:61252873:6

85 45988 1254419

ENSGOOOOO 107758 :PPP3 CBxhrlO:- ENSG00000171853:TRAPPC12:chr ENSG00000102385:DRP2:chrX:+:l :75199629:75199659:75198178:7520448 2:+:3481465:3481566:3469466:348 00502078:100502153:100500438:10 2 2616 0503077

ENSG00000110066 :KMT5B : chr 11 : ENSG00000143850:PLEKHA6:chrl

ENSGOOOOO 196498 :NC0R2 :chrl2 :- : 124812092: 124812179: 124810916: 1248 :67947598:67947667:67942650:679 :204212241:204212391:204210942: 15390 53247 204216492

ENSG00000168502:MTCLl:chrl8: ENSG00000137842:TMEM62:chrl

ENSG00000166377:ATP9B:chrl8:+:771 +:8792995:8793118:8786089:87962 5:+:43441305:43441349:43441077: 35393:77135426:77134101:77137246 29 43443987 ENSG00000010810:FYN:chr6:- ENSGOOOOO 127616 : SMARC A4 : chr ENSG00000074964:ARHGEF10L:c : 112167791: 112167832: 112101838: 1121 19:+:11144442: 11144541:11144193 hrl:+: 17975048: 17975170: 1796679 94170 :11144798 7:17981130

ENSG00000245573 :BDNF- ENSGOOOOO 154134:R0B03 xhrl 1 :

ENSG00000108219:TSPAN14:chrl0:+:8 ASxhrl 1 :+:27561566:27561663 :27 +: 124747832: 124748027 : 124747648

2228302:82228443:82222883:82248972 528445:27605815 : 124748193 ENSG00000048540:LM03:chrl2:- ENSG00000155189:AGPAT5:chr8:

ENSG00000219626:FAM228B:chr2:+:2 : 16753647: 16753802: 16713472: 167 +:6599181:6599272:6590171:66125 4384375:24384483:24369956:24390495 60869 71 ENSG00000107890:ANKRD26:chrl0:- ENSG00000183077:AFMID:chrl7: ENSG00000154370:TRIMll:chrl:- :27294551:27294652:27284076:2729584 +:76198783:76198832:76183514:76 :228588664:228588895:228584866:

5 202991 228589766

ENSGOOOOO 135631 :RAB 11FIP5 xh

ENSG00000134954:ETSl:chrll:- ENSG00000083097:DOPEYl:chr6: r2:- : 128350085: 128350346: 128333522: 1283 +:83863612:83863762:83863339:83 :73306778:73308791:73303310:733 54717 863898 15177

ENSG00000176049:JAKMIP2:chr5:

ENSG00000166348:USP54:chrl0:- ENSG00000120694:HSPHl:chrl3:-

:75279554:75279750:75277505:7528334 :31726988:31727088:31725328:317 : 147015784: 147015847: 147012341:

0 28769 147016527

ENSGOOOOO 111670:GNPTAB xhrl ENSGOOOOO 107863 : ARHGAP21 xh

ENSG00000196914:ARHGEF12:chrll: 2:- rlO:- +: 120280102: 120280159: 120278532: 120 : 102150197: 102150344: 102147317: :24879134:24879408:24878231:248 291461 102150989 80570

ENSG00000105053:VRK3:chrl9:- ENSG00000164172:MOCS2:chr5:- ENSG00000159082:SYNJl:chr21:-

:50498447:50498532:50498176:5050404 :52397188:52397339:52396364:523 :34014404:34014443:34014276:340

6 97926 17955

ENSG00000147133 :TAF1 :chrX:+:7

ENSG00000138834:MAPK8IP3:chrl6:+ 0674856:70674862:70674707:70678 ENSG00000197774:EME2:chrl6:+:

: 1808978: 1808996: 1808160: 1809958 090 1824260:1824353:1823842:1825041

ENSG00000132881 :RSG1 xhrl :- ENSG00000132716:DCAF8:chrl:-

ENSG00000166685:COGl:chrl7:+:7120 : 16559387: 16559512: 16559141: 165 : 160231074: 160231115: 160213824:

3840:71203878:71203395:71204452 60106 160232065

ENSG00000128739 : SNRPNxhrl 5 : ENSG00000102078:SLC25A14:chr

ENSG00000196712:NFl:chrl7:+:29579 +:25219788:25220104:25213229:25 X:+: 129480517: 129480665 : 1294739

955:29580018:29576137:29585361 220504 50:129483224 ENSG00000131095:GFAP:chrl7:- ENSG00000117625 :RC0R3 :chrl :+:

ENSG00000145740:SLC30A5:chr5:+:68 :42981809:42982867:42980927:429 211486061:211486177:211477482:2

396633:68396756:68390165:68398888 85431 11486765

ENSG00000095637:SORBSl:chrl0

ENSG00000123562 :MORF4L2 :chrX:- ENSG00000172831:CES2:chrl6:+:6 : 102939608: 102939657: 102933528: 1029 :97194378:97194474:97192333:971 6971939:66972144:66969879:66974 40098 97246 124

ENSG00000135931:ARMC9:chr2:+:232 ENSG00000138674:SEC31A:chr4:- ENSG00000185753:CXorf38:chrX:-

209686:232209802:232196609:2322205 :83783686:83783725:83778917:837 :40498260:40498424:40496408:405

09 84470 06258

ENSG00000138115:CYP2C8:chrl0:- ENSG00000108010:GLRX3:chrl0: ENSG00000108387:SEPT4:chrl7:-

:96805566:96805708:96802834:9681809 +: 131977605: 131977684: 13197335 :56608840:56608912:56604339:566

1 3:131978376 09321

ENSG00000175287:PHYHDl:chr9:+:13 ENSG00000065427:KARS:chrl6:- ENSG00000144283:PKP4:chr2:+:15

1702877:131702994:131700057:131703 :75678180:75678360:75675621:756 9535092:159535166:159530512:159

723 81475 536940

ENSG00000204463 :B AG6 :chr6 : - ENSG00000137216:TMEM63B:chr

ENSG00000135318 :NT5E:chr6 :+: 86200 :31608161:31608305:31608083:316 6:+:44103064:44103103:44102833: 225:86200375:86199317:86201694 08421 44104085

ENSG00000084628:NKAIN1 :chrl :- ENSG00000157796:WDR19:chr4:+:

ENSG00000204387:C6orf48:chr6:+:318 :31658093:31658174:31656861:317 39201097:39201213:39188224:3920

03187:31803232:31802977:31805012 12340 5261

ENSG00000117625 :RCOR3:chrl:+: ENSG00000141314:RHBDL3:chrl7

ENSG00000179262:RAD23A:chrl9:+:l 211486061:211486303:211477482:2 :+:30611677:30611836:30593319:3

3059327:13059366:13059172:13059499 11486765 0615810

ENSG00000068650:ATPllA:chrl3:+:ll ENSG00000075413:MARK3:chrl4: ENSG00000088298:EDEM2:chr20:-

3532530:113532617:113530255:113536 +: 103966492: 103966537: 10394682 :33719444:33719586:33714178:337

126 7:103969218 30175

ENSG00000259522:RP11- ENSG00000079819:EPB41L2 :chr6 :

468E2.2:chrl4:- ENSG00000151276 :M AGI1 : chr3 : -

:24651997:24652048:24651609:2465218 :65344738:65344827:65342807:653 : 131199243: 131199390: 131188721: 1 46873 131206235

ENSG00000168802 : CHTF8 : chrl 6 : - ENSGOOOOO 143933 : CALM2 : chr2 : -

ENSG00000132275 :RRP8 :chrl 1 : - :69154955:69155073:69152428:691 :47399552:47399598:47397903:474 :6622155 :6622285 :6622005 :6624633 55338 03374 ENSG00000126214:KLCl:chrl4:+:1041 ENSG00000097033 : SH3 GLB 1 :chrl ENSGOOOOO 156642 :NPTN:chrl 5 59889:104159971:104158762:10416699 :+:87195770:87195794:87194124:8 :73889362:73889710:73884478:739 1 7200284 25465

ENSGOOOOO 183696 :UPP1 :chr7 :+:48

ENSG00000102024:PLS3:chrX:+: 11487 ENSG00000147364:FBX025:chr8: 139266:48139384:48134424:481414 4421: 114874448: 114871290:114874719 +:417719:417746:413150:418714 20 ENSG00000163349:HIPKl:chrl:+:1144 ENSG00000101294:HM13:chr20:+: ENSG00000078687:TNRC6C:chrl7 99745 : 114499806 : 114499433 : 11450068 30155880:30156027:30149539:3015 :+:76073241:76073415:76071359:7 7 6922 6075475

ENSG00000116337:AMPD2:chrl:+:110 ENSG00000157087:ATP2B2:chr3:- ENSGOOOOO 189056 :RELN:chr7 :-

167924:110168055:110162900:1101682 : 10377812: 10377984: 10370809: 103 : 103118835: 103118841: 103113355:

83 79859 103123319

ENSG00000058668:ATP2B4:chrl:+:203 ENSG00000100461:RBM23:chrl4:- ENSG00000163618:CADPS:chr3:-

702350:203702528:203696699:2037086 :23377541:23377608:23375577:233 :62467397:62467544:62464091:624

73 78691 77013

ENSG00000168309:FAM107A:chr3

ENSG00000118369:USP35:chrll:+

ENSG00000123349:PFDN5:chrl2:+:536 :77919902:77920009:77900203:779 :58574932:58574996:58555592:586 90213:53690335:53689423:53691633 20493 13142 ENSG00000141837:CACNAlA:chrl9:- ENSG00000165650:PDZD8:chrl0:- ENSG00000128591:FLNC:chr7:+:l : 13347262: 13347432: 13346544: 1335233 : 119100490: 119100613: 119078485: 28490029: 128490128: 128489632:12 4 119133866 8490437

ENSGOOOOO 182389: CACNB4 :chr2 :

ENSG00000047849 :MAP4 :chr3 :- ENSG00000019144 :PHLDB 1 :chrl 1 :48028872:48028923:48019423:4813026 :+: 118526569:118526602:11852640 : 152725690: 152725749: 152717334: 2 0:118527392 152727044

ENSG00000060971 : ACAA1 :chr3 :- ENSG00000143157:POGK:chrl :+: 1 ENSG00000276234:TADA2A:chrl :38173086:38173129:38170879:3817341 66816730:166816829:166810325:16 7:+:35802664:35802753:35800763: 6 6818174 35818625

ENSG00000187595:ZNF385C:chrl7:- ENSG00000151092 :NGLY 1 : chr3 : - ENSGOOOOO 152133 : GP ATCH 11 : ch

:40179635:40179746:40179151:4018006 :25777494:25777640:25775473 :257 r2:+:37316782:37317009:37315583:

7 92588 37319058 ENSG00000249853 :HS3 ST5 :chr6:- ENSG00000121067:SPOP:chrl7:-

ENSG00000136280:CCM2:chr7:+:4510 : 114549748: 114549942: 114489626: :47745388:47745440:47714171:477

9424:45109560:45104245:45113058 114663358 55294

ENSG00000154065:ANKRD29:chr

ENSG00000175497:DPP10:chr2:+:1162 18:- ENSG00000159082:SYNJl:chr21:-

57085:116257180:116101488:11628347 :21189187:21189255:21181273:211 :34007170:34007194:34004111:340

3 92055 11217

ENSG00000110675 :ELMODl:chrl 1 :+: 1 ENSG00000188735:TMEM120B:ch ENSG00000167323:STIMl:chrll:+ 07496122:107496258:107488932:10750 rl2:+: 122209393: 122209455: 12219 :4109931:4109968:4107773:411251 1142 9644:122211326 1

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000162086:ZNF75A:chrl6: ENSGOOOOO 165487 :MICU2 :chrl 3 : - : 131197813: 131197915: 131191266: 1311 +:3362676:3362768:3361948:33671 :22070190:22070299:22069457:220 99243 89 77064

ENSG00000110888:CAPRIN2:chrl

ENSG00000161647:MPP3:chrl7:- ENSGOOOOO 137411 : VARS2 : chr6 : +: 2:- :41903123:41903209:41901373:4190511 30889701:30889772:30889468:3088 :30872012:30872159:30869610:308 8 9892 73744

ENSG00000117425 :PTCH2:chrl :- ENSG00000163995:ABLIM2:chr4:-

ENSG00000171735:CAMTAl:chrl:+:69 :45295580:45295702:45295433:452 :7986565:7986620:7985281:800978

46299:6946406:6931900:6947713 96519 5

ENSG00000186654:PRR5:chr22:+: ENSGOOOOO 114867 :EIF4G1 :chr3 :+:

ENSG00000169592:IN080E:chrl6:+:30 45121123:45121176:45110551:4512 184033919:184034006:184032462:1

015888:30015978:30012361:30016541 2456 84035108

ENSG00000180229:HERC2P3:chrl

ENSG00000100296 :THOC5 :chr22: - 5:- ENSG00000164924:YWHAZ:chr8:-

:29927066:29927099:29925228:2992781 :20671447:20671623 :20668254:206 : 101964156: 101964353: 101961128:

9 88655 101965077

ENSG00000188130:MAPK12:chr22

ENSG00000136891:TEX10:chr9:- ENSG00000124608:AARS2:chr6:- : 103091421: 103091557: 103090244: 1031 :50687259:50687319:50686901:506 : 44274985 :44275131 :44274768:442 02538 87531 78730

ENSG00000168502:MTCLl:chrl8: ENSG00000254995:STX16-

ENSG00000118705 :RPN2 :chr20 :+: 3586 +:8783527:8784841:8777890:87962 NPEPLl:chr20:+:57266089:572662 6804:35866852:35862498:35869705 29 83:57248767:57266779 ENSG00000214706 :IFRD2 :chr3 : - ENSG00000204628:RACKl:chr5:- :50326877:50327193:50326368:5032735 ENSG00000227232:WASH7P:chrl: : 180665098: 180665239: 180664042: 9 -: 17232: 17368: 17055: 17605 180666486

ENSG00000115525: ST3GAL5:chr2

ENSG00000153391:IN080C:chrl8:- ENSG00000149761 :NUDT22:chrl 1

:33060416:33060527:33048706:3307768 :+:63995039:63995138:63994604:6 :86097194:86097381:86090608:861

2 3996718 15946

ENSGOOOOO 111879 :FAM184A:chr6

ENSG00000152117:AC093838.4:chr2:+: ENSG00000084444:FAM234B:chrl

132273174:132273320:132266181:1322 : 119295592: 119295739: 119288117: 2:+: 13232722: 13232943: 13229077:

73886 119296188 13235936

ENSG00000168255:POLR2J3:chr7:

ENSG00000143702:CEP170:chrl:-

ENSG00000112320:SOBP:chr6:+: 10790 : 102208456: 102208631:102182109: :243349080:243349374:243336148: 8283:107908379:107854814:107979410 102210281 243349560

ENSG00000117597:DIEXF:chrl :+: ENSGOOOOO 136141 :LRCH1 :chrl 3 :

ENSG00000006194 :ZNF263 : chrl 6 :+: 33 210016795:210017041:210015792:2 +:47289694:47289799:47286732:47 35680:3335754:3335239:3336022 10024548 297355 ENSG00000132694:ARHGEFll:chrl:- ENSGOOOOOH4956:DGUOK:chr2: ENSGOOOOO 143622 :RIT 1 : chrl : - : 156941488: 156941608: 156939835: 1569 +:74184251:74184367:74177859:74 : 155874393: 155874401: 155874293: 47995 185272 155874521

ENSG00000143786:CNIH3:chrl:+: ENSG00000006283 : CACNA1 G:chr

ENSG00000131626:PPFIAl:chrll:+:70 224872497:224872545:224868728:2 17:+:48695219:48695269:48694932 197099 :70197129 :70194526 :70200406 24918163 :48695408

ENSG00000204227 :RING1 :chr6 :+: ENSGOOOOO 100241 : SBF 1 : chr22 : -

ENSGOOOOO 198039 :ZNF273 :chr7 :+:643 33178934:33179324:33177563:3317 :50895462:50895540:50895102:508 77407:64377496:64363797:64377958 9505 97683

ENSG00000169398:PTK2:chr8:- ENSG00000171097:KYATl:chr9:-

ENSG00000060656:PTPRU:chrl:+:2963 : 141679825: 141679834: 141678523: : 131608958: 131609138: 131607690:

3640:29633658:29631940:29637255 141684396 131644175

ENSG00000228315:GUSBPll:chr22:- ENSG00000099957 :P2RX6 :chr22 :+

:24042912:24043032:24002187:2404761 :21380299:21380365:21380187:213 ENSG00000143850:PLEKHA6:chrl

5 80708 :204224753:204224807:204220739:

204225929

ENSG00000104093 :DMXL2 :chrl 5 :

ENSG00000123636:BAZ2B:chr2:- ENSG00000140538:NTRK3:chrl5:- : 160284451:160284553: 160269056: 1602 :88524456:88524591:88522694:885 :51751794:51751857:51750992:517 84821 76087 55575

ENSG00000145428:RNF175:chr4:- ENSG00000067840 :PDZD4 :chrX: - ENSG00000078747:ITCH:chr20:+:3 : 154669796: 154669979: 154649513: 1546 : 153072733: 153072824: 153072295: 2981575:32981687:32957276:32996 72589 153095693 456

ENSG00000132716:DCAF8:chrl:- ENSG00000151276 MAGI 1 :chr3 : -

ENSG00000133226:SRRMl:chrl:+:249 : 160231074: 160231140: 160213824: :65361419:65361620:65350621:653

80796:24980834:24979523:24981345 160232238 64935

ENSG00000179912:R3HDM2:chrl

ENSG00000266338:NBPF15:chrl:+:148 2:- ENSG00000166169:POLL:chrl0:-

577071:148577251:148568877:1485773 :57682639:57682693:57677839:576 : 103342519: 103342648: 103340173:

57 82791 103347002

ENSG00000028203:VEZT:chrl2:+: ENSG00000076685 :NT5C2 :chrlO : -

ENSG00000136280:CCM2:chr7:+:4507 95650925:95651015:95650398:9565 : 104865114: 104865138: 104861083: 7851:45078025:45039456:45103516 6681 104865462 ENSG00000102181:CD99L2:chrX:- ENSG00000181555 : SETD2 : chr3 : - ENSG00000161395:PGAP3:chrl7:- : 149983334: 149983409: 149963959: 1499 :47142947:47143045:47139571:471 :37832866:37833008:37830932:378 99703 55365 40849

ENSG00000121578 :B4GALT4:chr3

ENSG00000142856:ITGB3BP:chrl:- ENSG00000138326:RPS24:chrl0:+: :63955753:63955889:63944504:6397419 : 118953991: 118954074: 118949091: 79799958:79799983 :79797062:7980 8 118955699 0372

ENSG00000022840:RNF10:chrl2:+:120 ENSG00000163513:TGFBR2:chr3: 977170:120977271 :120972771 : 1209842 +:30664690:30664765:30648469:30 ENSG00000007376:RPUSDl:chrl6 07 686238 :-:837555:837645:837477:838255

ENSG00000165695:AK8:chr9:- ENSG00000120963:ZNF706:chr8:-

ENSG00000168824:NSGl:chr4:+:43888 : 135668020: 135668162: 135602921: : 102214560: 102214675: 102213971:

45:4388900:4388370:4389330 135690024 102216877

ENSG00000184056:VPS33B:chrl5:

ENSG00000198952: SMG5 :chrl :- ENSG00000105327:BBC3:chrl9:- : 156236331:156236469: 156236171: 1562 :91560192:91560254:91557663:915 : 47729820:47730011 :47725175 :477 37260 65383 34185

ENSG00000149182 : ARFGAP2 :chr

ENSG00000170231 :FABP6:chr5 :+: 1596 11:- ENSG00000112290: WASFl:chi6> 55479: 159655699: 159640826: 15965655 :47193831:47193884:47193351:471 : 110499800: 110499945: 110448832: 2 98066 110501043

ENSG00000185046:ANKSlB:chrl2

ENSG00000170954:ZNF415:chrl9:- ENSG00000140859:KIFC3:chrl6:-

:53626753:53626908:53625996:5363610 :57793036:57793065:57792821:577 : 99201621 : 99201696:99194903:994

8 94637 46934

ENSG00000106070:GRB10:chr7:- ENSG00000245573 :BDNF- ENSG00000141696:P3H4:chrl7:- :50674033:50674111:50660795:5068043 AS hrl 1 :+:27679787:27680009:27 :39959538:39959683:39959231:399 7 661552:27680717 63047

ENSG00000143207:RFWD2:chrl:- ENSG00000090661 : CERS4 :chrl 9 :+ ENSG00000131966 : ACTR10 :chrl4 : : 176105623: 176105683: 176104222: 1761 :8275589:8275746:8274378:830622 +:58680348:58680416:58675825:58 18141 4 681922

ENSG00000144040 : SFXN5 : chr2 : -

ENSG00000108788:MLX:chrl7:+:4072 ENSG00000162004:CCDC78:chrl6 :73195576:73195662:73188377:732

0487:40720577:40719673:40720854 :-:775412:775580:775293:775793 15386

ENSG00000140463:BBS4:chrl5:+:7301 ENSG00000168477:TNXB:chr6:- ENSG00000164176 :EDIL3 : chr5 : -

5129:73015188:73009191:73016868 :32011783:32011906:32011669:320 :83525672:83525702:83476339:835 12157 49901

ENSG00000120438:TCPl:chr6:- ENSG00000184162 :NR2C2 AP hrl ENSG00000230606:AC159540.1:ch : 160209089: 160209175: 160208903: 1602 9:- r2:- 10436 : 19313278: 19313384: 19313207: 193 :98088031:98088249:98082014:980 13599 88547

ENSG00000006283 : CACNA1 G:chrl7 :+ ENSG00000009950:MLXIPL:chr7:- ENSG00000128739:SNRPN:chrl5: :48695219:48695290:48694932:4869545 :73010968:73011119:73010809:730 +:25219544:25219603:25213229:25 7 11194 221451

ENSG00000219626:FAM228B:chr2:+:2 ENSG00000142046:TMEM91:chrl ENSG00000021762:OSBPL5:chrll:

4362239:24362320:24358057:24392224 9:+:41889465:41889537:41888826:

41889767 :3141773:3141854:3140861:314322 6 ENSG00000076555:ACACB:chrl2:+:10 ENSG00000134138 :MEIS2 :chrl 5 : - ENSG00000159147:DONSON:chr2

9646969:109647158:109644661:109650 :37388489:37388608:37387815:373 1:-

640 90167 :34955793:34955972:34954552:349

56895

ENSG00000029363 :BCLAF1 :chr6:- ENSG00000081189 :MEF2C:chr5 : - ENSGOOOOO 154277 :UCHL 1 :chr4 :+: : 136590278: 136590441: 136589477: 1365 :88026027:88026051:88025164:880 41259131:41259143:41259026:4126 90574 27545 2663

ENSG00000160813:PPPlR35:chr7:- ENSG00000141294:LRRC46:chrl7: ENSGOOOOOO 10803 :SCMH1 xhrl :- : 100033253: 100033390: 100033156: 1000 +:45913031:45913141:45912765:45 :41540890:41541123:41514562:415 33470 913398 78954

ENSG00000178252:WDR6:chr3:+:4905 ENSG00000073060:SCARBl:chrl2 ENSG00000155329:ZCCHC10:chr5

0723:49051549:49044964:49051642

: 125267228: 125267357: 125263132: : 132358532: 132358598: 132342612: 125270986 132362188

ENSG00000132466:ANKRD17:chr4:- ENSG00000101972:STAG2:chrX:+ ENSG00000186575:NF2:chr22:+:30

:74005247:74006000:74000979:7400745 : 123155216: 123155281: 123094716: 079008:30079053:30074312:300907

7 123156380 40

ENSG00000203805:PLPP4:chrl0:+:122 ENSG00000147439:BIN3:chr8:- ENSG00000138867:GUCDl:chr22:-

334642:122334813:122280607:1223488 :22494037:22494099:22488091 :224 :24944884:24944969:24944041:249

14 94434 51582

ENSG00000204843 :DCTN1 :chr2:- ENSG00000113163 :COL4A3BP:ch ENSG00000128512:DOCK4:chr7:- :74601449:74601467:74598855:7460455 r5:- : 111424152: 111424179: 111424008:

8 :74695134:74695212:74685512:746 111428717 96029

ENSG00000170004:CHD3:chrl7:+:7810 ENSG00000146215 : CRIP3 :chr6 : - ENSG00000135049:AGTPBPl:chr9

918:7811020:7810806:7811211 :43273804:43273862:43273613:432

73956 :88293249:88293313:88292497:882 96182

ENSG00000173681:CXorf23:chrX:- ENSG00000245573 :BDNF- ENSGOOOOO 180488 :MIGA1 xhrl :+: : 19953926: 19954016: 19948058: 1995562 ASxhrl 1 :+:27561566:27561663 :27 78325724:78325811 :78325071 :7832 2 528445:27661391 6908

ENSG00000149403:GRIK4:chrll:+:120 ENSGOOOOO 176444 : CLK2 : chrl : - ENSG00000004534:RBM6:chr3:+:5 732667: 120732829: 120707553 : 1207447 : 155238498: 155238586: 155238150: 0036872:50036946:50012825:50085 74 155239278 677

ENSG00000113851 :CRBN:chr3 :- ENSG00000179889:PDXDCl:chrl6 ENSG00000175267:VWA3A:chrl6: :3216846:3216950:3215945:3221304 :+: 15095632: 15095744: 15092262:1 +:22161107:22161252:22159627:22 5098043 163831

ENSG00000174485:DENND4A:chrl5:- ENSG00000060237:WNKl:chrl2:+ ENSG00000106070:GRB10:chr7:-

:65992881:65993010:65989721:6599338 : 1010726: 1010819: 1009836: 101361 :50771517:50771605:50742355:508

8 8 60920

ENSG00000135164:DMTFl:chr7:+:867 ENSG00000091136:LAMBl:chr7:- ENSG00000163618:CADPS:chr3:-

83705:86783844:86781871:86792810 : 107576723: 107576818: 107576101: :62499312:62499381 :62484943 :625 107577537 01733

ENSG00000204653:ASPDH:chrl9:- ENSG00000031823 :RANBP3 :chrl 9 ENSG00000158106:RHPNl:chr8:+: :51016183:51016268:51015030:5101773 144461998:144462345:144461678:1 4 :5941631:5941718:5933490:595792 44462758 8

ENSG00000106133 :NSUN5P2 :chr7: - ENSG00000168958:MFF:chr2:+:22 ENSGOOOOOO 10270 : STARD3NL xh

:72422690:72422834:72420735:7242489 8211941:228212100:228205096:228 r7:+:38256625:38256679:38254706:

7 217229 38256788

ENSG00000143537:ADAM15:chrl:+:15 ENSG00000089847 : ANKRD24 xhr ENSGOOOOO 151466 : SCLT 1 : chr4 : -

5034051:155034122:155033965:155034 19:+:4202022:4202087:4200168:42 : 129864150: 129864343: 129812292:

720 07238 129867161 Table 2b. IRIS screening results of tumor AS events in 22 GBM samples, b. IRIS identified 1,738 tumor-recurrent AS events with high tumor-specificity in GBM samples (Prioritized set)

AS_event AS_event

ENSG00000127603:MACFl:chrl:+:39844132:39844195:39 ENSG00000150712:MTMR12:chr5:- ENSG00000081377:CDC14B:chr9:-

838268:39844874 :32233878:32234040:32230453:32239106 :99277930:99278074:99266071:99284787

ENSG00000197223:ClD:chr2:- ENSG00000226210:ABC7- ENSG00000271447 :MMP28 : chrl 7 : -

:68280192:68280418:68274451:68290076 42389800N19.1:chrl2:+:87880:88017:87703:88569 :34093215:34093913:34083438:34094770

ENSG00000095637:SORBSl:chrl0:- ENSG00000139746:RBM26:chrl3:- ENSG00000005379:TSPOAPl:chrl7:-

: 97110965:97111133:97106209: 97114638 :79927287:79927359:79918929:79928573 :56381698:56381760:56379808:56382421

ENSG00000105483:CARD8:chrl9:- ENSG00000138326:RPS24:chrl0:+:79797722:79797740:79 ENSG00000106077 : ABHD 11 :chr7 :-

:48726975:48727125:48725112:48733694 797062:79799961 :73151258:73151440:73151021:73151891

ENSG00000127663:KDM4B:chrl9:+:5119128:5119230:51 ENSG00000110514:MADD:chrl 1 :+:47310518:47310578:4 ENSG00000134909:ARHGAP32:chrll:-

10829:5119663 7308085:47310941 : 128910822: 128910904: 128868363: 128932174

ENSG00000061273:HDAC7:chrl2:- ENSG00000214174:AMZ2Pl:chrl7:- ENSG00000075391 :RASAL2:chrl :+: 178439827:178439858

:48189688:48189799:48189550:48189989 :62969359:62969635:62969045:62970672 : 178436556: 178442209

ENSG00000124214 : ST AU 1 : chr20 : - ENSG00000153391:IN080C:chrl8:- ENSG00000079819:EPB41L2:chr6:-

:47782533:47782822:47770608:47790731 :33058245:33058313:33048706:33077682 : 131191467: 131191521: 131191266: 131206235

ENSG00000148057:IDNK:chr9:+:86243787:86243874:862 ENSG00000198838:RYR3:chrl5:+:34148084:34148252:34 ENSG00000274769:RP11-

38136:86256462 147113:34149980 493E12.3:chr2:+:61344491:61344520:61343205:61344601

ENSG00000068724:TTC7A:chr2:+:47178740:47178872:47 ENSG00000173264:GPR137:chrll:+:64055536:64055686:6 ENSG00000033627:ATP6V0Al:chrl7:+:40666306:4066647

177665:47183977 4055418:64055811 8:40665996:40673044

ENSG00000007545:CRAMPl:chrl6:+: 1716073: 1716178:1 ENSG00000122786:CALDl:chr7:+: 134620438: 134620516: ENSG00000198925 :ATG9A:chr2:- 715139:1716422 134618141:134625842 :220093155:220093204:220092775:220094256

ENSG00000166167:BTRC:chrl0:+: 103190101: 103190209: ENSG00000082898 :XP01 :chr2 : - ENSG00000196652:ZKSCAN5:chr7:+:99117449:99117532:

103113985:103221737 :61761692:61761813:61761038:61764696 99110214:99123435

ENSG00000138614:INTS14:chrl5:- ENSG00000138162:TACC2:chrl0:+: 123988860: 123989001 ENSG00000137814:HAUS2:chrl5:+:42852979:42853068:4

:65899496:65899780:65897574:65903435 : 123987523: 123996909 2851606:42853467

ENSG00000134444:KIAA1468:chrl8:+:59947592:5994767 ENSG00000075151 :EIF4G3 xhrl : - ENSG00000136044:APPL2:chrl2:-

5:59947089:59947878 :21329205:21329301:21307720:21377358 : 105570653: 105570794: 105569860: 105571003

ENSG00000008382:MPND:chrl9:+:4354945:4355018:435 ENSG00000205581:HMGNl:chr21:- ENSG00000050130:JKAMP:chrl4:+:59953430:59953522:5

4417:4357249 :40717755:40719218:40717200:40719304 9951311:59954391

ENSG00000165801:ARHGEF40:chrl4:+:21555478:215556 ENSG00000078403:MLLT10:chrl0:+:21906040:21906136: ENSG00000227036:LINC00511:chrl7:-

22:21554025:21556126 21903853:21940601 :70416840:70417105:70400957:70424376

ENSG00000107036:RICl:chr9:+:5753535:5753646:575323 ENSG00000146707 :POMZP3 : chr7 : - ENSG00000163466:ARPC2:chr2:+:219103386:219103573:2

8:5754840 :76240770:76240908:76239532:76247499 19093573:219110142

ENSG00000127054:INTS11 :chrl :- ENSG00000115310:RTN4:chr2:- ENSG00000073921 :PICALM:chrl 1 :- : 1258560: 1258667: 1256473 : 1259960 :55255299: 55255356: 55214834:55276880 :85671717:85671820:85670103:85685750 ENSG00000196295:AC005154.6:chr7:- ENSG00000245910:SNHG6:chr8:- ENSG00000090097 :PCBP4 :chr3 :- :30590933:30591095:30590397:30603346 :67834558:67834627:67834349:67834848 :51996825:51996908:51995320:52001341

ENSG00000167766:ZNF83:chrl9:- ENSG00000152726:FAM21B:chrl0:+:47915877:47915964: ENSG00000075826 : SEC3 lB hrlO:-

:53119970:53120128:53118050:53122188 47913703:47919941 : 102256891:102257037: 102256188: 102257423

ENSG00000119844:AFTPH:chr2:+:64806619:64808407:64 ENSG00000162341:TPCN2:chrll:+:68848867:68848967:6 ENSG00000114026:OGGl:chr3:+:9800870:9800970:97985

800202:64812555 8846488:68902902 00:9807492

ENSG00000197381 :ADARB1 :chr21 :+:46548316:46548488 ENSG00000115977:AAKl:chr2:- ENSG00000132530:XAFl:chrl7:+:6665204:6665356:66639

:46494708:46591524 :69723116:69723212:69709944:69732700 20:6665473

ENSG00000160201:U2AFl:chr21> ENSG00000172292:CERS6:chr2:+: 169622831:169622855: ENSG00000070010:UFDlL:chr22:-

:44521475:44521542:44520629:44524424 169622258:169626019 : 19462992 : 19463125 : 19459331 : 19466605 ENSG00000150712:MTMR12:chr5:- ENSG00000196504:PRPF40A:chr2:- ENSG00000100239:PPP6R2:chr22:+:50827414:50827540:5 :32235067:32235235:32230453:32239106 : 153535569: 153535623: 153533989: 153535865 0810579:50832321 ENSG00000072110:ACTNl:chrl4:- ENSG00000049089 : COL9A2 :chrl :- ENSG00000148481:MINDY3:chrl0:- :69345705:69345786:69345240:69346678 :40780909:40781081:40780059:40781261 : 15880226: 15880278: 15879317: 15883424 ENSG00000114209:PDCD10:chr3:- ENSG00000184381 :PL A2G6 :chr22 :- ENSG00000129675 :ARHGEF6:chrX:- : 167443188: 167443261: 167438061: 167452001 :38524275: 38524437: 38522456:38525460 : 135760094: 135760115: 135758876: 135761693 ENSG00000129353:SLC44A2:chrl9:+: 10753572: 10753697 ENSG00000204152:TIMM23B:chrl0:+:51374369:5137442 ENSGOOOOO 137501 : S YTL2 :chrl 1 : - : 10753127: 10753954 8:51371646:51381438 :85425455 :85425550: 85420543:85429832

ENSG00000169062:UPF3A:chrl3:+: 115051776: 115051875 ENSG00000143776:CDC42BPA:chrl:- ENSG00000136518:ACTL6A:chr3:+: 179293190: 179293292 : 115047602: 115051993 :227247073 :227247112 :227235711 :227257477 : 179292255: 179294004 ENSG00000127527:EPS15Ll:chrl9 ENSG00000133030:MPRIP:chrl7:+: 17083920: 17083983:1 ENSG00000112320:SOBP:chr6:+: 107954717: 107956673: 10

: 16487932: 16488065 : 16472795 : 16495939 7083402:17088136 7854814:107979410 ENSG00000148399:DPH7:chr9:- ENSG00000196352:CD55:chrl:+:207513735:207513853:20 ENSG00000143416:SELENBPl:chrl:- : 140459344: 140459410: 140459058: 140459536 7512762:207532890 : 151341479: 151341665: 151340795: 151342188 ENSG00000074266:EED:chrll:+:85977124:85977258:859 ENSG00000197530:MIB2:chrl:+: 1560344: 1560565: 156028 ENSG00000162385:MAGOH:chrl:- 75305:85988021 1:1560665 :53699213:53699324: 53694626:53701248

ENSG00000108848:LUC7L3:chrl7:+:48828657:48828723: ENSG00000162585:FAAP20:chrl:- ENSG00000136754:ABIl:chrl0:-

48828213:48829560 :2121151:2121220:2116952:2125077 :27044583:27044670:27040712:27047990

ENSG00000073008:PVR:chrl9:+:45162009:45162168:451 ENSG00000124831:LRRFIPl:chr2:+:238666098:23866619 ENSGOOOOO 148660 :CAMK2G:chrlO : - 61178:45164558 1:238664830:238667371 :75585036:75585105:75583842:75587846

ENSG00000225177 :RP11 -

ENSG00000124006 :0B SL 1 :chr2: - 390P2.4:chr6:+: 139015529: 139015684: 139013754: 1390177 ENSG00000066855:MTFRl:chr8:+:66601800:66601834:66 :220422064:220422340:220421445:220423946 33 594686:66605878 ENSG00000056586:RC3H2:chr9:- ENSG00000105186:ANKRD27:chrl9:- ENSG00000197622:CDC42SEl:chrl:- : 125620201: 125620372: 125618157: 125620947 :33137364:33137521:33135385:33140587 : 151029126: 151029262: 151028469: 151031954 ENSG00000089159:PXN:chrl2:- ENSG00000182979:MTAl:chrl4:+: 105933043: 105933079: ENSGOOOOO 106638 :TBL2 :chr7 : - : 120657009: 120657894: 120653464: 120659425 105932915:105935803 :72990870:72991031 :72988843 :72992749 ENSG00000101198:NKAIN4:chr20:- ENSG00000181163 :NPM1 :chr5:+: 170818308: 170818428: 1 ENSGOOOOO 133026 :MYH 10 : chrl7:- :61873890:61873975:61872858:61875375 70815010:170832305 :8479960:8479990:8473130:8480553 ENSG00000257303 :RP11-

977G19.11:chrl2:+:56706190:56706283:56693971:5670831 ENSG00000139624:CERS5:chrl2:- ENSG00000119866 :BCLllA:chr2:- 2 :50526744:50527851:50524477:50528328 :60687816:60688879:60679801:60689416

ENSG00000123562:MORF4L2:chrX:- ENSG00000196781:TLEl:chr9:- ENSG00000183955:KMT5A:chrl2:+: 123873979: 12387410 : 102933426: 102933579: 102931979: 102940098 :84267098 : 84267203 : 84249216 :84300590 1:123868755:123875176

ENSG00000197694:SPTANl:chr9:+: 131355261: 13135532 ENSG00000103227:LMFl:chrl6:- ENSG00000125457:MIF4GD:chrl7:- 1:131353904:131356453 :983990:984145:961079:984243 :73263826:73263982:73263711:73264163

ENSG00000135297:MT01:chr6:+:74190015:74190090:741 ENSG00000001167:NFYA:chr6:+:41048549:41048636:410 ENSG00000127419:TMEM175:chr4:+:942198:942403:9419

89849:74190397 46903:41051784 42:944208

ENSG00000135250:SRPK2:chr7:- ENSG00000198563:DDX39B:chr6:- ENSGOOOOO 187838 :PLSCR3 :chrl7 : - : 104766694: 104766787: 104766321 : 104767439 :31508929:31509104:31508441:31509726 :7296462:7296683 :7296271 :7296785 ENSG00000228486:LINC01125 :chr2:+:98318523 :9831863 ENSG00000176473:WDR25:chrl4:+: 100847246: 10084808 ENSG00000175224:ATG13:chrll:+:46686398:46686509:46 0:98317767:98319131 3:100842841:100934357 681035:46686932 ENSG00000095397:WHRN:chr9:- ENSG00000204209 :DAXX:chr6:- ENSG00000090857:PDPR:chrl6:+:70164325:70164447:701 : 117228546: 117228672: 117188693 : 117240832 :33288512: 33289344: 33288368:33290638 63025:70166053 ENSG00000122786:CALDl:chr7:+: 134620438: 134620516: ENSG00000004534:RBM6:chr3:+:50036872:50036946:500 ENSG00000100209:HSCB:chr22:+:29141851:29141996:291 134618828:134625842 00118:50085677 40692:29147228

ENSG00000068305:MEF2A:chrl5:+: 100243566: 10024359 ENSG00000162004:CCDC78:chrl6:- ENSGOOOOO 120318 : ARAP3 :chr5 :- 0:100230633:100246933 :775445:775580:775293:775793 : 141034928: 141034967: 141034002: 141035187

ENSG00000105357:MYH14:chrl9:+:50727410:50727434:5 ENSG00000070501:POLB:chr8:+:42196529:42196587:421 ENSG00000140905:GCSH:chrl6:-

0726606:50728841 96203:42202470 :81118067:81118199:81116568:81124205

ENSG00000168763:CNNM3:chr2:+:97497705:97497805:9 ENSG00000122481 :RWDD3 :chrl :+:95709766:95710254:9 ENSG00000172869:DMXLl:chr5:+: 118542528: 118542591:

7494871:97498288 5699871:95712311 118539131:118552595

ENSG00000143537:ADAM15:chrl:+: 155034379: 15503445 ENSG00000154743:TSEN2:chr3:+: 12560557: 12560696: 12 ENSG00000163719:MTMR14:chr3:+:9739394:9739550:973 1:155033965:155034720 546730:12570386 1827:9743473

ENSG00000137959:IFI44L:chrl:+:79095404:79095600:790 ENSG00000163644:PPMlK:chr4:- ENSG00000137210:TMEM14B:chr6:+: 10755374: 10755465

86256:79101021 :89199687:89199794:89198395:89205557 : 10749931:10829239

ENSG00000007376:RPUSDl:chrl6:- ENSG00000132716:DCAF8:chrl:- ENSG00000234127 :TRIM26 :chr6 : -

:837067:837179:836928:837353 : 160231074: 160231148: 160213824: 160231906 :30172432:30172542:30168915:30181081

ENSG00000151923:TIALl:chrl0:- ENSG00000129467:ADCY4:chrl4:- ENSG00000163138:PACRGL:chr4:+:20703763:20703844:2

: 121339982: 121340358: 121339522: 121341433 :24790921:24791182:24789094:24791271 0702410:20706088

ENSG00000142459:EVI5L:chrl9:+:7921977:7922010:7920 ENSG00000165475:CRYLl:chrl3:- ENSGOOOOO 163864 :NMNAT3 : chr3 : -

954:7923076 :21013731:21013893:21006435:21063508 : 139356804: 139356904: 139346606: 139396546

ENSG00000203875 : SNHG5 :chr6: - ENSG00000128563 :PRKRIP1 :chr7:+: 102006401 : 10200652 ENSGOOOOO 187742 : SECISBP2 :chr9 :+:91954778 :91954868 :

:86387141:86387210:86375865:86387853 3:102004858:102016269 91953495:91956261

ENSG00000226210:ABC7- ENSG00000131748:STARD3:chrl7:+:37814961:37815073: ENSGOOOOO 102710 : SUPT20H : chr 13 : -

42389800N19.1:chrl2:+:88256:88392:87703:88569 37814775:37815303 :37584688:37584792:37583946:37586328

ENSG00000010803:SCMHl:chrl:- ENSG00000160570:DEDD2:chrl9:- ENSG00000141699:FAM134C:chrl7:-

:41625396:41625605:41618413:41626546 :42720831:42721197:42719404:42724225 :40739851:40739882:40738909:40744073

ENSG00000170634:ACYP2:chr2:+:54278094:54278187:54 ENSG00000006194:ZNF263:chrl6:+:3335680:3335754:333 ENSG00000214078:CPNEl:chr20:-

200947:54284375 4205:3336022 :34246851:34246936: 34220845:34252723

ENSG00000135164:DMTFl:chr7:+:86792554:86792648:86 ENSG00000095637:SORBSl:chrl0:- ENSG00000243943:ZNF512:chr2:+:27806524:27806583:27

781871:86792810 :97154757:97154832:97144042:97156976 806009:27820933

ENSG00000118518:RNF146:chr6:+: 127606352: 127606493 ENSG00000073712 :FERMT2 :chrl4:- ENSG00000005801:ZNF195:chrll:- : 127601485: 127607760 :53348513:53348546:53348187:53360010 :3382972:3383119:3381795:3392172

ENSG00000133226:SRRMl:chrl:+:24989673:24989715:24 ENSG00000121310:ECHDC2:chrl:- ENSG00000143612:Clorf43:chrl:-

989295:24993305 :53370705:53372283:53370505:53373539 : 154192311 : 154192413 : 154187050: 154192817

ENSG00000134780:DAGLA:chrll:+:61503032:61503116: ENSG00000178209:PLEC:chr8:- ENSGOOOOO 151092 :NGLY1 : chr3 : -

61502474:61503210 : 144996671 : 145000052: 144996563 : 145000951 :25761620:25761682:25761126:25770623

ENSG00000108175:ZMIZl:chrl0:+:81070680:81070941:8 ENSGOOOOO 163660 : CCNL l:chr3:- ENSG00000118518:RNF146:chr6:+: 127603431:127603540:

1067328:81072398 : 156867075: 156867174: 156866378: 156867273 127601749:127607194

ENSG00000031003:FAM13B:chr5:- ENSG00000068745:IP6K2:chr3:- ENSGOOOOO 122085 :MTERF4:chr2 : -

: 137292165: 137292231: 137290065: 137295304 :48732134:48732257:48731673 :48732522 :242033691:242033847:242029459:242036657

ENSG00000004455:AK2:chrl:- ENSG00000055955:ITIH4:chr3:- ENSG00000121310:ECHDC2:chrl:-

:33497144:33497262:33490168:33502336 :52852067:52852184:52851074:52852272 :53370705:53370762:53370505:53373539

ENSG00000136754:ABIl:chrl0:- ENSG00000140416:TPMl:chrl5:+:63356262:63356341:63 ENSG00000168803:ADAL:chrl5:+:43639213:43639294:43

:27044583:27044670:27040712:27054146 354844:63358094 638178:43641104

ENSG00000068724:TTC7A:chr2:+:47185633:47185691:47 ENSG00000070081:NUCB2:chrll:+: 17336932: 17337022:1 ENSG00000116754:SRSFll:chrl:+:70696777:70696886:70

184146:47202111 7333667:17351673 694238:70697541

ENSG00000113649:TCERG1 :chr5:+: 145847903 : 14584796 ENSG00000154114:TBCEL:chrll:+: 120924338: 120924441 ENSGOOOOO 167110 : G0LGA2 : chr9 : - 6:145843356:145849106 : 120918376: 120925760 : 131029472: 131029553: 131028604: 131029736

ENSG00000152219:ARL14EP:chrll:+:30352432:3035292 ENSG00000112031:MTRFlL:chr6:- ENSG00000073921 :PICALM:chrl 1 :-

1:30344749:30354412 : 153312319: 153312456: 153311230: 153313991 :85671717:85671820:85670103:85692171

ENSG00000165495:PKNOX2:chrl 1 :+: 125281641 : 1252817 ENSG00000121940:CLCCl:chrl:- ENSG00000130731:METTL26:chrl6:- 61:125267958:125298907 : 109504930: 109505091: 109493070: 109505982 :685517:685774:685340:686093

ENSG00000161956:SENP3:chrl7:+:7469011:7469081:746 ENSG00000205336:ADGRGl:chrl6:+:57675502:57675620 ENSG00000183696:UPPl:chr7:+:48141420:48141467:4813 8904:7470243 :57673582: 57684164 4424:48146469

ENSG00000099998:GGT5:chr22:- ENSG00000197111:PCBP2:chrl2:+:53861588:53861627:53 ENSG00000204842 : ATXN2 : chrl 2 : - :24616459:24616552:24616084:24620963 861077:53862560 : 111891480: 111891649: 111890644: 111893832 ENSG00000196295:AC005154.6:chr7:- ENSG00000102882:MAPK3:chrl6:- ENSG00000205464:ATP6APlL:chr5:+:81600752:81601300 :30590933:30591011:30590397:30601081 :30128457:30128606:30128324:30128990 :81600669:81605975 ENSG00000088298:EDEM2:chr20:- ENSGOOOOO 100105 :PATZ 1 : chr22 : - ENSG00000104852:SNRNP70:chrl9:+:49605370:49606844 :33719444:33719586:33714178:33725682 :31724772:31724845:31723295:31731677 :49604728:49607890 ENSG00000163531:NFASC:chrl:+:204931235:204931286: ENSG00000173210:ABLIM3:chr5:+: 148622053: 148622101 ENSG00000140416:TPMl:chrl5:+:63353396:63353472:633 204926954:204937376 : 148619451 : 148624443 53138:63353911

ENSG00000072736:NFATC3:chrl6:+:68248231:68248335: ENSG00000163531:NFASC:chrl:+:204971723:204971876: ENSGOOOOO 106771 :TMEM245 :chr9 :- 68225678:68260252 204957934:204978684 : 111848276: 111848300: 111843223 : 111849452

ENSG00000250222:CTC-

ENSG00000130731:METTL26:chrl6:- ENSG00000172530:BANP:chrl6:+:88008653:88008813:87 338M12.5:chr5:+: 180620341: 180620467: 180619140: 180621 :684888:685063 :684797:686093 985121:88014641 233 ENSG00000160613:PCSK7:chrll> ENSG00000171793:CTPSl:chrl:+:41473120:41473217:414 ENSG00000170791:CHCHD7:chr8:+:57125320:57125468:5

: 117078369: 117078451 : 117077876: 117078685 71766:41474330 7124396:57127156

ENSG00000168256:NKIRAS2:chrl7:+:40174587:4017465 ENSG00000088367:EPB41Ll:chr20:+:34761685:34761876: ENSG00000172366:MCRIP2:chrl6:+:696471:696608:69224

8:40174490:40175671 34680735:34763472 9:697782

ENSG00000196440:ARMCX4:chrX:+: 100741009: 1007410 ENSG00000025423:HSD17B6:chrl2:+:57157001:57157198 ENSG00000114209:PDCD10:chr3:- 79:100673988:100742179 :57146365:57167617 : 167443188: 167443261:167438061:167452593

ENSG00000131149:GSEl:chrl6:+:85698620:85698734:85 ENSG00000162910:MRPL55:chrl:- ENSGOOOOO 122033 :MTIF3 :chr 13 : -

697220:85699581 :228296137:228296722:228296022:228296961 :28015153:28015214:28014586:28019224

ENSG00000196218:RYRl:chrl9:+:39061246:39061333:39 ENSG00000161791:FMNL3:chrl2:- ENSG00000166377:ATP9B:chrl8:+:77132824:77132882:77

058557:39062658 :50040421:50040536:50039686:50040668 119462:77133897

ENSG00000170049:KCNAB3:chrl7:- ENSG00000121753:ADGRB2:chrl:- ENSG00000197343:ZNF655:chr7:+:99160816:99160889:99

:7826773 :7826862:7826497 :7827028 :32193625:32193682:32193206:32193782 158318:99161485

ENSG00000130733:YIPF2:chrl9:- ENSGOOOOO 153310 :F AM49B : chr8 : - ENSG00000151914:DST: chr6 : -

: 11038305: 11038392: 11036449: 11038474 : 130916744: 130916831:130915596: 130951853 :56329482:56329554:56328562:56330875

ENSG00000120549:KIAA1217:chrl0:+:24783428:2478353 ENSG00000105426 :PTPRS :chrl 9:- ENSGOOOOO 164896 :FASTK:chr7:-

3:24762989:24784075 :5216730:5216778:5215606:5218430 : 150773999: 150774114: 150773919: 150774396

ENSG00000076685:NT5C2:chrl0:- ENSGOOOOO 133872 : S ARAF : chr8 : - ENSG00000144199:FAHD2B:chr2:-

: 104860508: 104860700: 104859776: 104860801 :29931392:29931544:29927575:29940362 :97757198:97757449: 97751935:97760437

ENSG00000140939:NC)L3:chrl6:+:67205054:67205360:67 ENSG00000198208:RPS6KLl:chrl4:- ENSGOOOOO 146067 :FAM193B :chr5 :-

204477:67208064 :75375803:75375864:75375635:75376245 : 176974168: 176974229: 176966148: 176981249

ENSG00000140299:BNIP2:chrl5:- ENSGOOOOO 138606 : SHF :chrl5:- ENSG00000132535:DLG4:chrl7:-

:59970946:59971033:59970286:59971790 :45464346:45464516:45464200:45467416 :7095211:7095321 :7094677:7096263

ENSG00000089177:KIF16B:chr20:- ENSG00000132199:ENOSFl:chrl8:- ENSG00000214022 :REPIN1 :chr7 :+: 150067802 : 150067973 :

: 16354901: 16355054: 16352406: 16359449 :691203:691276:691106:693881 150066957:150068316

ENSG00000127483 :HP1BP3 :chrl :- ENSG00000140995:DEF8:chrl6:+:90015824:90016046:900 ENSG00000169398:PTK2:chr8:-

:21106837:21107033:21106404:21113141 15222:90020650 : 141772466: 141772487: 141771361:141774332

ENSG00000187953:PMS2CL:chr7:+:6770264:6770358:676 ENSG00000121957:GPSM2:chrl:+: 109428128: 109428200: ENSG00000137700:SLC37A4:chrll:-

9932:6771527 109419850:109439485 : 118897215: 118897398: 118896790: 118897646

ENSG00000095637:SORBSl:chrl0:- ENSG00000105865:DUS4L:chr7:+: 107211589: 107211711: ENSG00000049540:ELN:chr7:+:73480273:73480327:73480 : 97110972:97111133:97106209: 97114638 107207631:107215632 062:73482986 ENSG00000204790: CBWD6 :chr9 :- ENSG00000130066:SATl:chrX:+:23802410:23802520:238 ENSGOOOOO 119185 :ITGB 1BP1 :chr2 : - :69234829:69234952:69229668:69235561 01826:23803444 :9560118:9560229:9558861:9563501 ENSG00000108591:DRG2:chrl7:+: 18001583: 18001673: 17 ENSG00000166783:KIAA0430:chrl6:- ENSGOOOOO 161547 : SRSF2 : chr 17 : - 997287:18007114 : 15719228: 15719657: 15719030: 15724188 :74731853:74731957:74731240:74732235

ENSG00000257621 :PSMA3 -AS 1 :chrl4 :- ENSG00000132600:PRMT7:chrl6:+:68382244:68382334:6 ENSG00000047621 : C 12orf4 : chrl 2 : - :58740696:58740728:58734111:58758352 8380183:68386150 :4626226:4626355:4614546:4627223 ENSG00000121753:ADGRB2:chrl:- ENSG00000149100:EIF3M:chrll:+:32610557:32610681:32 ENSG00000107771:CCSER2:chrl0:+:86259630:86259715: :32205710:32205779:32205635:32205947 605475:32611092 86237420:86273204 ENSG00000185630:PBX1 :chrl :+: 164789308: 164789421 :1 ENSG00000093167 :LRRFIP2 :chr3 : - ENSG00000136870:ZNF189:chr9:+: 104161676: 104161812: 64781386:164790773 :37107714:37107816:37107433:37114280 104161471:104162207

ENSG00000101294:HM13:chr20:+:30155880:30156083:30 ENSG00000110514:MADD:chrl 1 :+:47330530:47330593 :4 ENSG00000029363 :BCLAF1 :chr6:-

149539:30156922 7330250:47330831 : 136588166: 136588313: 136582615: 136589299

ENSG00000148655:C10orfll:chrl0:+:78295555:78295745: ENSG00000023191 :RNH1 xhrl 1 :- ENSG00000108312:UBTF:chrl7:-

78084243:78316966 :504823:504996:502249:507112 :42289711:42289822:42289374:42290186

ENSGOOOOO 166444 : ST5 :chrl 1 : - ENSG00000136153:LM07:chrl3:+:76412275:76412332:76 ENSGOOOOO 130749 :ZC3H4 :chrl 9 : -

:8751496:8752756:8747756:8772167 410593:76414220 :47572348:47572600:47571126:47575034

ENSG00000214765 : SEPT7P2 :chr7 : - ENSG00000099957:P2RX6:chr22:+:21380299:21380618:21 ENSG00000169756:LIMSl:chr2:+: 109297424: 109297568: 1

:45765782:45765835:45764079:45767776 380187:21380708 09297226:109300340

ENSG00000010361:FUZ:chrl9:- ENSG00000102317:RBM3 :chrX:+:48434202:48434471 :484 ENSG00000155970:MICU3:chr8:+: 16973951: 16974109: 169

:50312634:50312832:50312515:50314619 34055:48434701 71710:16976215

ENSG00000154556:SORBS2:chr4:- ENSGOOOOO 101190 : TCFL5 : chr20 : - ENSG00000122490:PQLCl:chrl8:-

: 186598150: 186598792: 186583396: 186599576 :61485367:61485509:61473449:61491476 :77693968:77694022:77679400:77703328

ENSG00000155366:RHOC:chrl> ENSG00000125846:ZNF133:chr20:+: 18286941: 18287037:1 ENSG00000214022 :REPIN1 :chr7 :+: 150067848: 150067973 :

: 113247721: 113247745: 113246428: 113249699 8269248:18295712 150066030:150068316

ENSG00000115414:FNl:chr2:- ENSG00000150433:TMEM218:chrll:- ENSG00000061273 :HD AC7 : chrl 2 : -

:216236831:216237023:216236738:216238044 : 124972027 : 124972213 : 124971199: 124972629 :48196006:48196057:48192755:48213549

ENSG00000162961:DPY30:chr2:- ENSG00000130731:METTL26:chrl6:- ENSG00000175470:PPP2R2D:chrl0:+: 133748397: 1337485

:32117060:32117203:32108531:32142994 :684888:684956:684797:686093 10:133748059:133753534

ENSG00000153113 :CAST:chr5:+:96062497:96062563 :960 ENSG00000165219:GAPVDl:chr9:+: 128104497: 12810457 ENSG00000076685:NT5C2:chrl0:-

58402:96063192 8:128103543:128109097 : 104871501 : 104871562: 104866463 : 104934614

ENSG00000166946:CCNDBPl:chrl5:+:43486278:4348633 ENSG00000066557:LRRC40:chrl:- ENSG00000075413:MARK3:chrl4:+: 103966492: 10396653

5:43485001:43486612 :70652947:70653021:70650597:70671072 7:103964865:103969218

ENSG00000099622:CIRBP:chrl9:+: 1270865 : 1271035 : 126 ENSG00000243156 :MICAL3 :chr22:- ENSG00000121067 : SPOP :chrl 7 : - 9409:1271327 :18310409:18310547:18305826:18314619 :47745388:47745440:47700238:47753256

ENSG00000156990:RPUSD3:chr3:- ENSG00000181163 :NPM1 :chr5:+: 170827156: 170827214: 1 ENSG00000136717:BINl:chr2:-

:9880668:9880855:9879891:9881867 70815010:170832305 : 127809830: 127809938: 127808819: 127810997

ENSG00000124275:MTRR:chr5:+:7873485:7873639:78710 ENSG00000156170:NDUFAF6:chr8:+:96046235:96046350 ENSG00000177311:ZBTB38:chr3:+: 141157084: 141157207:

36:7875370 :96044326:96047681 141122873:141161230

ENSG00000110888:CAPRIN2:chrl2:- ENSGOOOOOH7859:OSBPL9:chrl:+:52135105:52135184:5 ENSGOOOOO 136699 : SMPD4 :chr2 : -

:30872012:30873849:30869610:30876192 2117713:52179674 : 130918758: 130918845: 130914248: 130921946

ENSG00000197343:ZNF655:chr7:+:99160810:99160889:9 ENSG00000064042:LIMCHl:chr4:+:41689856:41689934:4 ENSG00000103126:AXINl:chrl6:-

9158318:99161485 1687847:41691543 :341189:341297:339607:343487

ENSGOOOOOH5459:ELMOD3:chr2:+:85582198:85582293: ENSG00000145362:ANK2:chr4:+: 114294440: 114294605:1 ENSG00000164576:SAP30L:chr5:+: 153832015: 153832055:

85581952:85582677 14294329:114302612 153830773:153832961

ENSG00000141258:SGSM2:chrl7:+:2270564:2270699:226 ENSG00000117308:GALE:chrl:- ENSG00000070476 :ZXDC : chr3 : -

8635:2274555 :24122998:24123076:24122755:24123186 : 126160607: 126160789: 126158570: 126180377

ENSG00000162910:MRPL55:chrl:- ENSG00000165322:ARHGAP12:chrl0:- ENSG00000197343:ZNF655:chr7:+:99169310:99169415:99

:228296137:228296175:228296019:228296655 :32128232:32128247:32120728:32128564 158318:99169867

ENSG00000004864 : SLC25 A13 :chr7 :- ENSG00000112305 :SMAPl:chr6:+:71501391:71501472:71 ENSG00000156414:TDRD9:chrl4:+: 104516201: 104516274

:95864113:95864229:95838289:95906507 483128:71508359 : 104516017: 104518317

ENSG00000172661:WASHC2C:chrl0:+:46254762:462548 ENSG00000183077:AFMID:chrl7:+:76201683:76201819:7 ENSG00000137103:TMEM8B:chr9:+:35835007:35835215:

49:46252587:46258835 6198832:76202026 35829952:35841130

ENSG00000124787:RPP40:chr6:- ENSG00000271853:RPl-178F15.5:chrl:- ENSG00000168802:CHTF8:chrl6:-

:5000796:5000865:5000138:5002334 : 153600596: 153600713: 153600074: 153604509 :69154955:69155073:69154552:69155338

ENSG00000233184:RP11-

ENSG00000135164:DMTFl:chr7:+:86823999:86824144:86 ENSG00000168894:RNF181:chr2:+:85823979:85824054:85 421L21.3:chrl:+: 101549016: 101549130:101491617:101552

823418:86824346 823772:85824567 407

ENSG00000140939:NOL3:chrl6:+:67207910:67207949:67 ENSG00000152784:PRDM8:chr4:+:81118116:81118370:81 ENSG00000158806:NPM2:chr8:+:21883157:21883283:218

204477:67208064 117755:81118778 83032:21890640

ENSG00000143774:GUKl:chrl:+:228336071:228336157:2 ENSG00000117868:ESYT2:chr7:- ENSG00000196199:MPHOSPH8:chrl3:+:20244979:202451

28335400:228336365 : 158545471: 158545534: 158542414: 158552176 04:20244503:20245345

ENSG00000117262:GPR89A:chrl:- ENSG00000068903 : SIRT2 :chrl9 : - ENSG00000070814:TCOF1 :chr5 :+: 149758791 : 149758971 : 1

: 145822813 : 145822859: 145818826: 145826887 :39389433: 39389558: 39389065:39390145 49758605:149759094

ENSG00000212694:LINC01089:chrl2:- ENSG00000189339:SLC35E2B:chrl:- ENSGOOOOO 172663 :TMEM134:chrl 1 :-

: 122240536: 122240690: 122239714: 122240784 : 1602947: 1603068: 1599911:1606901 :67232526:67232571:67232327:67234782

ENSG00000180964:TCEAL8:chrX:- ENSG00000114779:ABHD14B:chr3:- ENSG00000275052 :PPP4R3B :chr2 : - : 102509532: 102509605: 102508945: 102510005 :52005475:52005908:52004200:52007980 :55805382:55805478:55804492:55806814 ENSG00000111144:LTA4H:chrl2:- ENSG00000151692:RNF144A:chr2:+:7137046:7137192:70 ENSG00000114416:FXRl:chr3:+: 180693100: 180693192: 18 :96397615:96397698:96396842:96400091 81278:7154584 0688146:180693909 ENSG00000175662:TOMlL2:chrl7:- ENSG00000068400:GRIPAPl:chrX:- ENSGOOOOO 178209 :PLEC : chr8 : - : 17761082: 17761169: 17754266: 17764789 :48838206:48838284:48838103:48839390 : 145012568: 145012583: 145012408: 145012798 ENSG00000116604 :MEF2D:chrl :- ENSG00000184277:TM2D3:chrl5:- ENSG00000164548:TRA2A:chr7:- : 156446285: 156446306: 156445029: 156446803 : 102191898: 102191976: 102190364: 102192473 :23561739:23562051:23561459:23571407 ENSG00000164896:FASTK:chr7:- ENSG00000083535:PIBFl:chrl3:+:73547728:73547813:73 ENSG00000143409:MINDYl:chrl:- : 150773999: 150774323: 150773919: 150774396 505405:73572959 : 150974640: 150975444: 150974258: 150978787 ENSG00000103148:NPRL3:chrl6:- ENSG00000068120:COASY:chrl7:+:40717000:40717065:4 ENSG00000169919:GUSB:chr7:- : 174935: 175072: 169254: 180520 0716595:40717244 :65444713:65444898:65441189:65445210

ENSG00000065802:ASBl:chr2:+:239344351:239344654:2 ENSG00000163939:PBRMl:chr3:- ENSGOOOOO 124831 :LRRFIP1 :chr2:+:238667371 :238667464

39342336:239352982 :52592264: 52592429: 52584833:52595782 :238666191:238668706

ENSG00000223891:OSER1- ENSG00000168958:MFF:chr2:+:228217229:228217289:22 ENSG00000120910:PPP3CC:chr8:+:22396981:22397011:22

ASl:chr20:+:42843527:42843643:42839996:42853460 8207535:228220392 390531:22398127

ENSG00000036448:MYOM2:chr8:+:2089063:2089100:208 ENSG00000152154:TMEM178A:chr2:+:39934188:3993432 ENSG00000204463 :B AG6 :chr6 :-

8809:2091324 6:39931334:39944149 :31607276:31607423 :31607003 :31607975

ENSG00000136717:BINl:chr2:- ENSG00000183474:GTF2H2C:chr5:+:68863979:68864034: ENSG00000149925:ALDOA:chrl6:+:30077196:30077248:3

: 127815048: 127815177: 127808488: 127816586 68862880:68868271 0075826:30078554

ENSG00000082397:EPB41L3:chrl8:- ENSG00000178026:LRRC75B:chr22:- ENSG00000122481 :RWDD3 :chrl :+:95709766:95710271 :95

:5394675:5394792:5393477:5395065 :24984646:24985233:24984297:24985788 699871:95712311

ENSG00000117335:CD46:chrl:+:207941123:207941168:2 ENSG00000170653:ATF7:chrl2:- ENSG00000196295:AC005154.6:chr7:-

07940540:207943665 :53910798:53911138:53901811:53917059 :30590933:30591095:30590397:30601081

ENSG00000136856:SLC2A8:chr9:+: 130159654: 130159817 ENSG00000184939:ZFP90:chrl6:+:68573660:68573728:68 ENSG00000096746:HNRNPH3:chrl0:+:70097614:7009775 : 130159565: 130162185 567758:68591900 3:70097090:70098259 ENSG00000139116:KIF21A:chrl2:- ENSG00000150433:TMEM218:chrll:- ENSG00000090554:FLT3LG:chrl9:+:49982219:49982304:4 :39709733:39709772:39705355:39711874 : 124972027: 124972213: 124971199: 124972532 9979823:49983554 ENSG00000126214:KLCl:chrl4:+: 104151322: 104151373: ENSG00000136153:LM07:chrl3:+:76381615:76382335:76 ENSG00000111907:TPD52Ll:chr6:+: 125578243: 12557830 104145855:104151974 378677:76383289 4:125574901:125583979

ENSG00000164576:SAP30L:chr5:+: 153832015: 153832059 ENSG00000159592:GPBPlLl:chrl:- ENSGOOOOO 196776 : CD47 :chr3 : - : 153830773: 153832961 :46151247:46151292:46126897:46152664 : 107768465 : 107768498: 107766139: 107770785

ENSG00000169727:GPSl:chrl7:+:80010253:80010335:800 ENSG00000223959 : AFG3L lP:chrl6 :+: 90044046 : 90044210 ENSG00000130731:METTL26:chrl6:-

09840:80011149 :90039173:90046649 :685517:685774:684797:686093

ENSG00000204842:ATXN2:chrl2:- ENSG00000181027:FKRP:chrl9:+:47251771:47251878:47 ENSG00000177479:ARIH2:chr3:+:48982568:48982614:489

: 111953957: 111954167: 111951343: 111956052 251345:47258668 65246:48999044

ENSGOOOOO 196923 :PDLIM7 :chr5 : - ENSG00000272752: STAG3L5P-PVRIG2P- ENSG00000066557 :LRRC40:chrl :-

: 176918807: 176918926: 176918421:176919405 PILRB:chr7:+:99950995:99951635:99950893:99952765 :70654774:70654956:70650597:70671072

ENSG00000136811:ODF2:chr9:+: 131231461: 131231632:1 ENSG00000139974:SLC38A6:chrl4:+:61510167:61510221 ENSG00000150787:PTS:chrll:+: 112100930: 112100953: 11

31223346:131233586 :61509930:61512063 2099396:112101348

ENSG00000143742:SRP9:chrl:+:225976735:225976843:22 ENSG00000168894:RNF181:chr2:+:85823979:85824054:85 ENSG00000185596:WASH3P:chrl5:+: 102506155: 1025064

5971070:225976941 823772:85824226 26:102501844:102512798

ENSGOOOOO 175287:PHYHD 1 :chr9 :+: 131700035 : 13170005 ENSG00000087087 : SRRT:chr7:+: 100480385 : 100480711 : 1 ENSG00000058799:YIPFl:chrl:- 7:131698924:131703723 00479862:100481690 :54354916:54355136: 54354659:54355385

ENSG00000124588:NQ02:chr6:+:3004728:3004885:30040 ENSG00000139197:PEX5:chrl2:+:7342617:7342812:73423 ENSGOOOOO 181929 :PRKAG1 :chrl2 :-

23:3006701 46:7342957 :49399525:49399635:49399326:49406844

ENSG00000105662:CRTCl:chrl9:+: 18854917: 18854965:1 ENSG00000126705:AHDCl:chrl:- ENSG00000176155:CCDC57:chrl7:-

8853836:18856632 :27884815:27885041:27861427:27885216 :80136902:80137065:80136481:80141649

ENSGOOOOO 116991 :SIPAlL2:chrl :- ENSG00000175575:PAAFl:chrll:+:73598084:73598144:7 ENSGOOOOO 111879 :FAM184A:chr6 :-

:232539870:232539924:232539317:232551239 3589864:73598398 : 119281933: 119282028: 119281349: 119282925

ENSG00000160818:GPATCH4:chrl:- ENSG00000133816:MICAL2:chrll:+: 12262586: 12262709: ENSG00000139323:POClB:chrl2:-

: 156567826: 156567913: 156566270: 156568018 12261132:12270730 :89818937:89819156:89815034:89853414

ENSG00000099917:MED15:chr22:+:20929399:20929519:2 ENSG00000204580:DDRl:chr6:+:30853401:30853457:308 ENSG00000215154:AC141586.5:chrl6:+:2660462:2661053:

0922918:20936897 50760:30856464 2653728:2663960

ENSG00000185347:C14orf80:chrl4:+: 105962216: 1059624 ENSG00000129116:PALLD:chr4:+: 169817699: 169817750: ENSG00000164211:STARD4:chr5:- 23:105960270:105963693 169815828:169819643 : 110837659: 110837786: 110836814: 110842027

ENSG00000117114:ADGRL2:chrl:+:82418670:82418709: ENSG00000132780:NASP:chrl:+:46082372:46082375:460 ENSG00000165795:NDRG2:chrl4:-

82417826:82421560 82065:46083134 :21486615:21486630:21486398:21486921

ENSG00000115239:ASB3:chr2:- ENSG00000158796 :DEDD :chrl : - ENSGOOOOO 138674 : SEC31 A:chr4 : -

:53992513:53992722:53978078:54013957 :161100604:161100633:161094316:161102340 :83819141:83819215:83803093:83821229

ENSG00000100722:ZC3H14:chrl4:+:89063077:89063152: ENSG00000143549:TPM3:chrl:- ENSG00000124440:HIF3A:chrl9:+:46815762:46815910:46

89044484:89073586 : 154143888: 154143964: 154143187: 154145383 815524:46823699

ENSG00000100813: ACINI :chrl4:- ENSG00000004455:AK2:chrl:- ENSG00000257337:RPll-983P16.4:chrl2:-

:23559190:23559310:23551045:23559730 :33497144: 33497262: 33487304:33502336 :53439383:53439437: 53434047:53439744

ENSG00000131148:EMC8:chrl6:- ENSG00000137504:CREBZF:chrll:- ENSG00000118705 :RPN2:chr20:+:35866804:35866852:358

:85813984:85814079:85813473:85814816 :85372680: 85372793: 85371641:85373432 65112:35869705

ENSG00000163681:SLMAP:chr3:+:57857362:57857425:57 ENSG00000160323:ADAMTS13:chr9:+: 136323031:136323 ENSG00000102125:TAZ:chrX:+: 153642437: 153642527: 15

850584:57875767 216:136321841:136324095 3641904:153647881

ENSG00000156256:USP16:chr21:+:30398029:30398092:30 ENSG00000116731 :PRDM2:chrl :+: 14099572: 14099683 : 14 ENSG00000088876:ZNF343:chr20:-

397098:30400193 075982:14142921 :2474164:2474223:2473471:2481301

ENSG00000077232:DNAJC10:chr2:+: 183600975: 1836011 ENSG00000156976 :EIF4A2:chr3 :+: 186506098 : 186506205 : ENSGOOOOO 152952 :PL0D2 :chr3 :-

13:183597269:183605025 186505671:186506913 : 145795648: 145795711:145791139: 145796902

ENSG00000204642:HLA- ENSG00000003509:NDUFAF7:chr2:+:37469777:37469836 ENSG00000089157:RPLP0:chrl2:-

F:chr6:+:29692807:29693083:29692225:29693223 :37468780:37471005 : 120636356: 120636573: 120635265: 120636656

ENSG00000100503:NIN:chrl4:- ENSG00000146556:WASH2P:chr2:+: 114352639: 11435273 ENSG00000166387:PPFIBP2:chrll:+:7662263:7662296:76

:51197640:51197701:51196441:51202233 8:114346280:114352945 61101:7662709

ENSG00000244560 :RP4-

ENSG00000115657:ABCB6:chr2:- 800G7.2:chr7:+: 148987028: 148987129: 148984867: 1489893 ENSG00000169598:DFFB:chrl:+:3782847:3782962:378256

:220082391:220082529:220081554:220082846 01 4:3784537

ENSG00000095637:SORBSl:chrl0:- ENSG00000003756:RBM5:chr3:+:50147811:50147896:501 ENSG00000124588:NQ02:chr6:+:3004728:3004885:30003

:97135729:97135813:97127456:97141441 47121:50148111 19:3006701

ENSG00000103197:TSC2:chrl6:+:2127598:2127727:21265 ENSG00000107521:HPSl:chrl0:- ENSG00000175287:PHYHDl:chr9:+: 131700035: 13170022

86:2129032 : 100190887: 100191048: 100190427: 100193696 3:131698924:131703723

ENSG00000171307:ZDHHC16:chrl0:+:99213555:9921360 ENSG00000148180:GSN:chr9:+: 124062333: 124062404: 12 ENSG00000198176:TFDPl:chrl3:+: 114292132: 114292211:

3:99212260:99214470 4030497:124064240 114291015:114294434

ENSG00000145725:PPIP5K2:chr5:+: 102523014: 10252307 ENSG00000169062:UPF3A:chrl3:+: 115056963: 115057019 ENSG00000090097 :PCBP4 :chr3 :- 7:102522140:102526542 : 115052104: 115057108 :51996825:51996908:51996104:52001341

ENSG00000004866:ST7:chr7:+: 116830186: 116830322: 116 ENSG00000025423:HSD17B6:chrl2:+:57156981:57157198 ENSG00000146733:PSPH:chr7:-

829447:116830887 :57146365:57167617 :56101073:56101187:56099747:56101653

ENSG00000010803:SCMHl:chrl:- ENSG00000163125 :RPRD2:chrl:+: 150414356: 150414434: ENSG00000132199:ENOSFl:chrl8:-

:41625396:41625605:41608784:41626546 150413499:150415706 :678695:678737:677872:683245

ENSG00000102977:ACD:chrl6:- ENSG00000172530:BANP:chrl6:+:88008653:88008791:87 ENSG00000189292 : ALKAL2 :chr2 :-

:67692457 :67692544:67692265 :67692622 985121:88014641 :286122:286203:283175:286289

ENSG00000168487:BMPl:chr8:+:22049747:22049848:220 ENSGOOOOO 151247 :EIF4E : chr4 : - ENSG00000080802 : CN0T4 : chr7 : -

49664:22051570 :99807604:99807697:99806212:99808229 : 135048605: 135048818: 135047938: 135078669

ENSG00000188157:AGRN:chrl:+:987372:987396:987195: ENSG00000117305 :HMGCL:chrl :- ENSGOOOOO 172785 : CB WD 1 : chr9 : -

988840 :24140679:24140828:24134813:24143164 : 161566: 161654: 156527: 162431

ENSG00000136643:RPS6KCl:chrl:+:213405465:2134055 ENSG00000102805:CLN5:chrl3:+:77572177:77572220:77 ENSG00000126217:MCF2L:chrl3 :+: 113745434: 113745509

98:213349835:213414044 570262:77574592 : 113744042: 113748827

ENSG00000136717:BINl:chr2:- ENSG00000272888:LINC01578:chrl5:+:93426973:934270 ENSGOOOOO 158161 :EYA3 :chrl : -

: 127808729: 127808819: 127808488: 127815048 08:93426416:93428744 :28354299:28354437:28343750:28362054

ENSG00000099219 :ERMP1 :chr9 :- ENSG00000184497 :TMEM255B:chrl3 :+: 114507857: 11450 ENSG00000206562:METTL6:chr3:-

:5805610:5805785:5801328:5810010 8001:114504785:114514708 : 15457004: 15457090: 15455669: 15457278

ENSG00000189046:ALKBH2:chrl2:- ENSG00000149100:EIF3M:chrll:+:32608557:32608690:32 ENSGOOOOO 132485 :ZRANB2:chrl :-

: 109527813: 109528012: 109526317: 109530311 605475:32611092 :71531360:71531435:71530820:71532458

ENSG00000140521:POLG:chrl5:- ENSG00000180229 :HERC2P3 :chrl5:- ENSGOOOOO 112425 :EPM2 A: chr6 : -

:89861169:89861268:89860767:89861771 :20666444:20666595:20663700:20667595 : 145956380: 145956622: 145948829: 146007257

ENSG00000154114:TBCEL:chrll:+: 120924259: 12092444 ENSG00000222011:FAM185A:chr7:+: 102412855: 1024128 ENSGOOOOO 167632 :TRAPPC9 :chr8 : -

1:120918376:120925760 97:102401858:102417699 : 141436713: 141436740: 141415797: 141445210

ENSG00000095203:EPB41L4B:chr9:- ENSG00000164924:YWHAZ:chr8:- ENSG00000161996:WDR90:chrl6:+:710057:710161:70937

: 111947768: 111947885: 111945077: 111954557 : 101964156: 101964536: 101961128: 101965077 6:710611

ENSG00000143164:DCAF6:chrl :+: 167992225: 167992285: ENSG00000197256:KANK2:chrl9:- ENSG00000158636:EMSY:chrll:+:76246938:76247103:76

167974031:168012262 : 11306297: 11306496: 11305266: 11308160 239510:76248838

ENSG00000163644:PPMlK:chr4:- ENSG00000197535:MY05A:chrl5:- ENSGOOOOO 134644 :PUM1 : chrl : -

:89199295:89199794:89198395:89205557 :52641014:52641023:52638658:52643450 :31452908:31453025:31447649:31454158

ENSG00000124440:HIF3A:chrl9:+:46832337:46832735:46 ENSGOOOOO 163818:LZTFL l:chr3:- ENSG00000257621 :PSMA3 -AS 1 :chrl4 : -

828896:46834412 :45879418:45879539:45877276:45883480 :58740696:58740853:58734111 :58758352

ENSG00000140575:IQGAPl:chrl5:+:90974452:90974484: ENSG00000171763:SPATA5Ll:chrl5:+:45699226:456994 ENSG00000140678:ITGAX:chrl6:+:31381301:31381419:31

90972898:90976950 21:45697703:45702569 374695:31382404

ENSG00000029534:ANKl:chr8:- ENSGOOOOO 107186 :MPDZ :chr9 : - ENSG00000072195:SPEG:chr2:+:220353219:220353387:22

:41518947:41519082:41513272:41519393 : 13147546: 13147657: 13140148: 13150509 0353032:220353499

ENSG00000137601:NEKl:chr4:- ENSG00000117791 :MARC2:chrl :+:220955119:220955274: ENSG00000048028:USP28:chrll:-

: 170359233: 170359410: 170354816: 170384393 220936392:220957260 : 113677210: 113677306: 113675768: 113679019

ENSG00000185164:NOM02:chrl6:- ENSG00000166833:NAV2:chrll:+:20104137:20104146:20 ENSG00000234745:HLA-B:chr6:-

: 18539334: 18539393: 18538946: 18540822 101755:20104552 :31322883:31323000:31322442:31323093

ENSG00000177192:PUSl:chrl2:+: 132423717: 132423820:1 ENSG00000008083:JARID2:chr6:+: 15410454: 15410596: 15 ENSG00000148484:RSUl:chrl0:-

32416857:132428083 374483:15452236 : 16858971: 16859083: 16824083: 16859313

ENSG00000162591:MEGF6:chrl:- ENSG00000283886:RPll-204M4.3:chr9:- ENSG00000072110:ACTNl:chrl4:-

:3413551:3413683 :3413347 :3413796 :42008850:42008960:41963942:42018927 :69345174:69345240:69343957:69345705

ENSG00000213983:APlG2:chrl4:- ENSG00000100813:ACINl:chrl4:- ENSG00000258301:RPll-488C13.5:chrl4:-

:24035770:24035895:24035628:24036319 :23536522:23537880:23535217:23538684 :77250035:77250194:77249119:77252427

ENSG00000180398:MCFD2:chr2:- ENSG00000103034:NDRG4:chrl6:+:58533047:58534981:5 ENSG00000132153:DHX30:chr3:+:47857452:47857618:47

:47136161:47136316:47135108:47142861 8528912:58537701 852201:47859511

ENSG00000120896:SORBS3:chr8:+:22423857:22423997:2 ENSG00000036448:MYOM2:chr8:+:2090299:2090322:208 ENSG00000249673 :N0P14-

2423385:22424173 9100:2091324 ASl:chr4:+:2939701:2939869:2939571:2940419

ENSG00000100429:HDAC10:chr22:- ENSG00000136527:TRA2B:chr3:- ENSGOOOOO 123562 :MORF4L2 :chrX: -

:50688491:50688589:50688393:50689199 : 185649364: 185649640: 185644522: 185655612 : 102933426: 102933548: 102931979: 102940098

ENSG00000130731:METTL26:chrl6:- ENSGOOOOO 136861 : CDK5RAP2 :chr9 : - ENSGOOOOO 173226 :IQCB 1 :chr3 : -

:685280:685340:684797:686093 : 123222849: 123223025: 123220900: 123230137 : 121491403: 121491560: 121489421: 121500589

ENSG00000138101:DTNB:chr2:- ENSG00000163281:GNPDA2:chr4:- ENSG00000134283:PPHLNl:chrl2:+:42768757:42768876:

:25606704:25606758:25602192:25610157 :44724100:44724259:44713154:44728490 42749024:42781257

ENSG00000102710:SUPT20H:chrl3:- ENSG00000112031:MTRFlL:chr6:- ENSG00000144283:PKP4:chr2:+: 159533250: 159533379: 15

: 37622700:37622736:37622073: 37625624 : 153312319: 153312551:153311230: 153313991 9530512:159536940

ENSG00000115694:STK25:chr2:- ENSG00000146416:AIGl:chr6:+: 143605246: 143605362: 14 ENSGOOOOO 138777 :PP A2 :chr4 : -

:242447420:242447550:242441123:242447857 3486320:143654418 : 106359106: 106359193: 106345479: 106367539

ENSG00000150403 :TMC03 :chrl3 :+: 114201614: 11420169 ENSG00000163629:PTPN13:chr4:+:87674161:87674218:87 ENSG00000178104:PDE4DIP:chrl:-

4:114193822:114202617 672277:87679412 : 144955215 : 144955292: 144946742: 144994590

ENSGOOOOO 106009 :BRAT 1 :chr7 :- ENSG00000114439:BBX:chr3 :+: 107508633: 107508723 : 10 ENSG00000104529:EEFlD:chr8:-

:2580463:2580528:2579522:2580612 7497366:107510086 : 144674816: 144675063 : 144672251 : 144679517

ENSG00000011143 :MKS1 :chrl7:- ENSG00000166927:MS4A7:chrll:+:60160157:60160259:6 ENSG00000196961:AP2Al:chrl9:+:50305790:50305856:50

: 56283825:56283908:56283741: 56284445 0157069:60161259 305398:50306205

ENSGOOOOO 176444: CLK2 :chrl :- ENSG00000162910:MRPL55:chrl:- ENSG00000196428:TSC22D2:chr3:+: 150140835: 15014090

: 155238498: 155238583: 155238150: 155239278 :228296137:228296209:228296019:228296655 7:150129095:150174862

ENSGOOOOO 114779 : ABHD 14B : chr3 : - ENSG00000109536:FRGl:chr4:+: 190876191: 190876306: 19 ENSG00000079974 :RABL2B :chr22 :-

:52005475:52005714:52004200:52007980 0873442:190878552 :51207882:51207977:51207552:51214199

ENSG00000143442:POGZ:chrl:- ENSG00000115084 : SLC35F5 :chr2 : - ENSG00000204619:PPPlRll:chr6:+:30036055:30036130:3

: 151413403: 151413562: 151403317: 151414556 : 114475329: 114475427: 114472772: 114476730 0035256:30036366

ENSG00000175575:PAAFl:chrll:+:73597973:73598144:7 ENSG00000182979:MTAl:chrl4:+: 105912003: 105912189: ENSG00000220785 :MTMR9LP:chrl : -

3589864:73598398 105911848:105916394 :32700304:32700415:32697785:32700552

ENSG00000136754:ABIl:chrl0:- ENSG00000134874:DZIPl:chrl3:- ENSG00000203666:EFCAB2:chrl:+:245165422:245165534

:27052808:27052889:27048167:27054146 :96251618:96251678:96246340:96258256 :245133745:245222687

ENSG00000132153:DHX30:chr3:+:47857452:47857618:47 ENSG00000125246:CLYBL:chrl3:+: 100515244: 10051534 ENSG00000087076 :HSD 17B 14 : chrl 9 : -

852201:47868836 6:100511303:100517071 :49334924:49335016:49318398:49337532

ENSG00000006194:ZNF263:chrl6:+:3338453:3338570:33 ENSG00000168958:MFF:chr2:+:228211941:228212100:22 ENSG00000145730:PAM:chr5:+: 102309819: 102310140: 10

36149:3339392 8205096:228220392 2296933:102325975

ENSG00000076864:RAPlGAP:chrl:- ENSG00000164548:TRA2A:chr7:- ENSG00000126653:NSRPl:chrl7:+:28490084:28490180:28

:21930327:21930405:21929406:21932558 :23561972:23562051:23561459:23571407 445191:28499559

ENSG00000139567:ACVRLl:chrl2:+:52307342:52307554 ENSG00000128159:TUBGCP6:chr22:- ENSG00000139631:CSAD:chrl2:-

:52307134:52308222 :50658679:50660303:50658444:50660456 :53565056:53565225: 53564286:53565665

ENSG00000258555:SPECC1L-

ADORA2A:chr22:+:24829098:24829704:24765288:248365 ENSG00000124789:NUP153xhr6:- ENSG00000105552:BCAT2xhrl9:-

50 : 17669205: 17669259: 17665616: 17669523 :49309773 :49309974:49303554:49314240

ENSG00000135407:AVILxhrl2:- ENSG00000124523:SIRT5xhr6:+: 13599263: 13599387: 135 ENSGOOOOO 172785 : CB WD 1 : chr9 : -

:58197306:58197452:58197174:58200142 97248:13601065 : 151304: 151427: 146158: 152033

ENSG00000134905: CARS2 :chrl 3 : - ENSG00000064655:EYA2xhr20:+:45700823:45700891:45 ENSG00000103034:NDRG4:chrl6:+:58534891:58534981:5

: 111302983: 111303447: 111299586: 111315797 644936:45717877 8528912:58537701

ENSG00000088367:EPB41Ll:chr20:+:34797409:34797820 ENSGOOOOO 196776 : CD47 xhr3 : - ENSGOOOOO 168066 : SF 1 xhrl 1 : -

:34785963:34800193 : 107769424: 107769449: 107766139: 107770785 :64540901:64540977:64537880:64543969

ENSG00000251022 :THAP9-AS 1 xhr4 ENSG00000143847:PPFIA4xhrl:+:203025911:203026078: ENSGOOOOO 138279 : ANXA7 xhrl 0 : -

:83816844:83816927:83816000:83819141 203025636:203028305 :75155801:75155867:75148172:75156276

ENSG00000198909:MAP3K3:chrl7:+:61712068:61712161 ENSG00000186501:TMEM222xhrl:+:27657475:27657628 ENSG00000164828:SUNlxhr7:+:872141:872238:856310:8

:61710162:61723393 :27657295:27658560 78434

ENSG00000143409:MINDY1 :chrl :- ENSG00000167515:TRAPPC2Lxhrl6:+:88925752:889258 ENSGOOOOO 106077 : ABHD 11 xhr7 :-

: 150974640: 150974799: 150974258: 150978787 51:88925197:88926300 :73151258:73151550:73151021:73151891

ENSG00000148187:MRRF:chr9:+: 125048317: 125048445:1 ENSG00000074266:EED:chrll:+:85979497:85979603:8597 ENSG00000138071:ACTR2:chr2:+:65469182:65469197:65

25047566:125054027 5305:85988021 467096:65473657

ENSG00000228109:MELTF- ENSG00000169946:ZFPM2xhr8:+: 106431371: 106431530: ENSG00000159788:RGS12:chr4:+:3430284:3430438:34298

ASl:chr3:+:196730967:196731230:196730841:196731364 106331209:106456507 96:3432133

ENSGOOOOO 100105 :P ATZ 1 : chr22 : - ENSG00000186998:EMIDlxhr22:+:29650191:29650276:2 ENSG00000185596:WASH3P:chrl5:+: 102512025: 1025122

:31724772:31724910:31723295:31731677 9639478:29651259 52:102506426:102512798

ENSG00000137501:SYTL2xhrll:- ENSG00000163281:GNPDA2xhr4:- ENSG00000165912:PACSIN3 xhrl 1 :-

: 85428525:85428573:85425550:85429832 :44719129:44719312:44713154:44728490 :47204224:47204360:47204110:47204554

ENSG00000127663:KDM4B:chrl9:+:5032876:5033042:50 ENSG00000177663:IL17RAxhr22:+: 17586742: 17586844:1 ENSGOOOOO 112425 :EPM2 Axhr6 : -

16350:5039846 7586492:17588616 : 146042036: 146042291:146007432: 146056333

ENSGOOOOO 128159 : TUB GCP6 xhr22 : - ENSG00000107679:PLEKHAlxhrl0:+: 124187791: 124187 ENSG00000183077:AFMIDxhrl7:+:76201683:76201834:7

:50659703:50660303:50658444:50660456 936:124186547:124189139 6198832:76202026

ENSG00000223745:CCDC18-ASlxhrl:- ENSGOOOOO 184465 : WDR27 : chr6 : - ENSG00000270580:PKDlP6-NPIPPlxhrl6:-

:93770944:93771027:93730329:93790191 : 170063658: 170063745 : 170062520: 170064261 : 15199405: 15199675: 15198615: 15199971

ENSG00000071564:TCF3xhrl9:- ENSG00000100503:NIN:chrl4:- ENSG00000173210:ABLIM3xhr5:+: 148617010: 148617166

: 1632330: 1632404: 1627425: 1646353 :51233024:51233114:51230682:51233497 : 148612863: 148619321

ENSG00000107863:ARHGAP21xhrl0:- ENSG00000122367:LDB3xhrl0:+:88441192:88441560:88 ENSG00000112305:SMAPlxhr6:+:71501391:71501472:71

:24911661:24911691:24910298:24918924 439914:88445434 483128:71546643

ENSG00000139620:KANSL2xhrl2:- ENSG00000090661:CERS4xhrl9:+:8275589:8275746:827 ENSGOOOOO 128699 :ORMDL 1 xhr2: -

:49056342:49056437:49054402:49061475 4378:8315927 : 190647739: 190647849: 190647328: 190648994

ENSG00000174628:IQCK:chrl6:+: 19775169: 19775434: 19 ENSG00000101187:SLC04Alxhr20:+:61299363:6129953 ENSG00000169592:IN080E:chrl6:+:30012532:30015978:3

745149:19800159 6:61299262:61299828 0012361:30016541

ENSG00000257529:RPL36A-

ENSG00000121067:SPOP:chrl7:- ENSG00000257103:LSM14A:chrl9:+:34706028:34706205: HNRNPH2xhrX:+: 100650322: 100650445: 100646810: 1006 :47745388:47745440:47700238:47755294 34699956:34706500 66923 ENSG00000143847:PPFIA4:chrl:+:203018803:203018895: ENSG00000170525:PFKFB3xhrl0:+:6270158:6270181:62 ENSG00000100599:RIN3xhrl4:+:93142877:93142951:931 203018108:203020896 68328:6274857 25814:93151331

ENSG00000249249:AC010226.4:chr5:+: 114938742: 114938 ENSG00000175334:B ANFl xhrl 1 :+:65770314:65770541 :6 ENSG00000093167 :LRRFIP2 :chr3 :- 853:114938157:114955764 5769984:65770705 :37107714:37107816:37107433:37116514

ENSG00000114956:DGUOK:chr2:+:74184251:74184367:7 ENSG00000163644:PPMlK:chr4:- ENSG00000157869:RAB28:chr4:- 4154179:74185272 :89189892:89190058:89186287:89198294 : 13462322: 13462452: 13383218: 13475941

ENSG00000185596:WASH3P:chrl5:+: 102513422: 1025135 ENSG00000198925:ATG9A:chr2:- ENSG00000130803:ZNF317:chrl9:+:9268509:9268751:926 55:102513250:102514107 :220093145:220093207:220092775:220094256 8070:9269501

ENSG00000168904:LRRC28:chrl5:+:99903310:99903470: ENSG00000205336:ADGRGl:chrl6:+:57675502:57675620 ENSG00000276087 :RP 11 - 99901716:99926234 :57662714:57684164 507M3.1:chr2:+:24362239:24362320:24358057:24369617 ENSG00000137501:SYTL2:chrll:- ENSG00000133392:MYHll:chrl6:- ENSG00000169062:UPF3A:chrl3:+: 115051733: 115051875: : 85422155:85422275:85420543: 85429832 : 15802659: 15802698: 15797980: 15808765 115047602:115051993 ENSG00000196557:CACNAlH:chrl6:+: 1262510: 1262528: ENSG00000143537:ADAM15:chrl:+: 155034379: 15503459 ENSG00000147576:ADHFEl:chr8:+:67355032:67355079:6 1262138:1263779 3:155033965:155034720 7344810:67356601

ENSG00000177697:CD151:chrll:+:834529:834803:83302 ENSG00000164896:FASTK:chr7:- ENSG00000122490:PQLCl:chrl8:-

6:836062 : 150774187: 150774323: 150773919: 150774396 :77690227:77690311:77664183 :77693968

ENSG00000058453:CROCC:chrl:+: 17297959: 17298142:1 ENSG00000161677:JOSD2:chrl9:- ENSG00000139546:TARBP2:chrl2:+:53898918:53899046: 7297262:17298854 :51010830:51010956:51009829:51013542 53898599:53899432

ENSG00000137965:IFI44:chrl:+:79126238:79126376:7912 ENSG00000141376:BCAS3:chrl7:+:59104226:59104271:5 ENSGOOOOO 114520 : SNX4 :chr3 : -

5168:79128388 9093262:59112026 : 125208251:125208307: 125199163: 125216184

ENSG00000233184:RP11-

ENSG00000144935:TRPCl:chr3:+: 142455220: 142455375: 421L21.3:chrl:+: 101549016: 101549130: 101543064: 101552 ENSGOOOOO 113504 : SLC 12 A7 : chr5 : - 142443573:142467099 407 : 1056696: 1056711 : 1053597: 1057585

ENSG00000147852:VLDLR:chr9:+:2651414:2651498:2650 ENSG00000122034:GTF3A:chrl3:+:28006867:28006941:2 ENSG00000121957:GPSM2:chrl:+: 109427896: 109428200: 516:2651873 8004758:28008275 109419850:109439485

ENSG00000133872:SARAF:chr8:- ENSG00000160746:AN010:chr3:- ENSG00000163872:YEATS2:chr3:+: 183490092: 183490351

:29931392:29931567:29927575:29940362 :43641875:43642073:43640158:43647205 : 183480067: 183491420

ENSGOOOOO 126106 : TMEM53 :chrl : - ENSG00000066056:TIEl:chrl:+:43773466:43773595:4377 ENSG00000176261:ZBTB80S:chrl:-

:45125845:45125967:45111136:45140002 3243:43774656 :33100302:33100393:33087549:33116033

ENSG00000172366:MCRIP2:chrl6:+:696471:696608:6922 ENSG00000168958:MFF:chr2:+:228195341:228195562:22 ENSG00000171163:ZNF692:chrl:-

49:697416 8190143:228197134 :249150571:249150621:249150145:249150712

ENSG00000182109:RPll-69E11.4:chrl:- ENSG00000124831:LRRFIPl:chr2:+:238647874:23864795 ENSG00000157216:SSBP3:chrl:-

:39990507:39990729:39988177:39994726 2:238636578:238657006 :54723741:54723822:54722859:54747110

ENSG00000224078:SNHG14:chrl5:+:25246504:25246860: ENSG00000116918:TSNAX:chrl:+:231699210:231699375: ENSG00000132405:TBClD14:chr4:+:7011603:7011675:70

25245521:25264173 231697001:231700273 02978:7012379

ENSG00000111731 :C2CD5 :chrl2:- ENSG00000178026:LRRC75B:chr22:- ENSGOOOOO 115977 : AAK1 :chr2 :-

:22611417:22611519:22610095:22622642 :24988183:24988390:24985917:24988829 :69709842:69709944:69708093 :69723116

ENSG00000168958:MFF:chr2:+:228217229:228217289:22 ENSG00000112715 :VEGFA:chr6:+:43748468:43748540:43 ENSG00000142949:PTPRF:chrl:+:44067741:44067768:440

8205096:228220392 746655:43752277 64584:44069086

ENSG00000165495:PKNOX2:chrll:+: 125279934: 1252817 ENSG00000178053:MLFl:chr3:+: 158306648: 158306713:1 ENSG00000016864:GLT8Dl:chr3:- 61:125267958:125298907 58289136:158310222 :52738739:52738968: 52734512:52739718 ENSG00000137312:FLOTl:chr6:- ENSG00000166169:POLL:chrl0:- ENSG00000074181 :N0TCH3 : chrl 9 : - :30709568:30709644:30709110:30709923 : 103343264: 103343438: 103342648: 103347002 : 15295105: 15295261: 15292612: 15295716 ENSG00000133687:TMTCl:chrl2:- ENSG00000258653 :RP5- ENSG00000145362:ANK2:chr4:+: 114293688: 114293781:1 :29736339:29736507:29725151:29757110 1021I20.4:chrl4:+:74389195:74389400:74388909:74390097 14290961:114294245

ENSG00000196295:AC005154.6:chr7:- ENSG00000022567:SLC45A4:chr8:- ENSG00000137842:TMEM62:chrl5:+:43426454:43426566: :30601081:30601744:30590397:30603346 : 142231675 : 142231864: 142229928: 142264087 43426180:43427709 ENSG00000165949:IFI27:chrl4:+:94582126:94582131:945 ENSG00000185024:BRFl:chrl4:- ENSG00000170946:DNAJC24:chrll:+:31436357:31436496 81226:94582131 : 105707601: 105707751:105695250: 105718843 :31392406:31447833

ENSG00000183963:SMTN:chr22:+:31496870:31496939:31 ENSG00000113649:TCERGl:chr5:+: 145889629: 14588972 ENSG00000143507:DUSP10:chrl:- 495882:31500301 3:145888808:145890003 :221912275:221913129:221879808:221915322

ENSG00000091129:NRCAM:chr7:- ENSG00000143774:GUKl:chrl:+:228329326:228329530:2 ENSG00000070010:UFDlL:chr22:-

: 107880402: 107880614: 107875132: 107953108 28328064:228333211 : 19463018: 19463125: 19459331:19466605

ENSG00000257218:GATC:chrl2:+: 120892735: 120892833: ENSG00000105223:PLD3:chrl9:+:40871459:40871492:408 ENSGOOOOO 186635 : ARAP 1 :chrl 1 : -

120884632:120894878 54675:40871624 :72403797:72403830:72399582:72404369

ENSG00000135083:CCNJL:chr5:- ENSG00000077522:ACTN2:chrl:+:236898934:236899020: ENSG00000072310 : SREBF1 :chrl7 : -

: 159707531: 159707745: 159686778: 159738864 236894614:236900421 : 17720861 : 17720905 : 17720771 : 17721009

ENSG00000073921 :PICALM:chrl 1 : - ENSG00000115657: ABCB6:chr2:- ENSG00000114956:DGUOK:chr2:+:74166036:74166149:74

:85689112:85689136:85687725:85692171 :220081373:220081554:220081187:220082846 154179:74184251

ENSG00000115760 :BIRC6:chr2:+:32815872:32816045:328 ENSG00000125772:GPCPDl:chr20:- ENSG00000115525:ST3GAL5:chr2:-

00433:32818981 :5566839:5566915:5564968:5573972 :86078386:86078826:86075327:86079982

ENSG00000139531:SUOX:chrl2:+:56393116:56393242:56 ENSG00000166073:GPR176:chrl5:- ENSG00000090661:CERS4:chrl9:+:8275566:8275746:8274 391507:56395995 :40099206:40099398:40094455:40212055 378:8315959

ENSG00000055483:USP36:chrl7:- ENSG00000182923 :CEP63 :chr3 :+: 134266176: 134266314:1 ENSG00000015153:YAF2:chrl2:- :76793867:76793961:76783740:76794481 34265130:134267903 :42592937:42593037:42555567:42631400 ENSG00000006125:AP2Bl:chrl7:+:33997875:33997917:3 ENSG00000106052:TAXlBPl:chr7:+:27855967:27856013: ENSG00000047849 :MAP4 :chr3 : - 3984810:33998772 27839709:27867356 :47910703:47910817:47908828:47912302

ENSG00000102125:TAZ:chrX:+: 153648043: 153648085: 15 ENSG00000007541:PIGQ:chrl6:+:631198:631341:630972: ENSGOOOOO 112651 :MRPL2 : chr6 : - 3647962:153648370 632247 :43023282:43023356:43022224:43025802

ENSG00000197302:ZNF720:chrl6:+:31734578:31734674: ENSG00000058404:CAMK2B:chr7:- ENSG00000107771:CCSER2:chrl0:+:86259630:86259715: 31724756:31765086 :44272420:44272465:44270653:44274237 86185649:86273204

ENSG00000081760: AACS:chrl2:+: 125603186: 125603311: ENSG00000184916:JAG2:chrl4:- ENSG00000177410:ZFASl:chr20:+:47897439:47897501:47 125599103:125618548 : 105617327: 105617441: 105617248: 105617619 895745:47905581

ENSG00000143252:SDHC:chrl:+: 161293403: 161293460:1 ENSG00000118518:RNF146:chr6:+: 127601660: 127601749: ENSGOOOOO 100320 :RBF0X2 :chr22 :- 61284215:161310383 127601485:127607760 :36152151:36152191:36142608:36155934

ENSG00000128739:SNRPN:chrl5:+:25219788:25220104:2 ENSG00000122678:POLM:chr7:- ENSG00000156958:GALK2:chrl5:+:49574183:49574282:4

5219603:25221451 :44116107:44116228:44114129:44118354 9531564:49584523

ENSGOOOOO 197226 : TB C 1D9B : chr5 : - ENSG00000144504:ANKMYl:chr2:- ENSGOOOOO 143393 :PI4KB :chrl :- : 179294444: 179294495: 179292888: 179294777 :241421599:241421678:241420514:241439374 : 151282686: 151282731:151280277: 151288048 ENSG00000162650:ATXN7L2:chrl:+: 110034648: 1100347 ENSG00000204580:DDRl:chr6:+:30853401:30853457:308 ENSG00000166377:ATP9B:chrl8:+:76973961:76974038:76 26:110034339:110035207 52487:30856464 967012:77013380 ENSG00000123562:MORF4L2:chrX:- ENSG00000166979:EVAlC:chr21:+:33829904:33830028:3 ENSG00000110921 :MVK:chrl2:+: 110019199: 110019355:1 : 102939608: 102939657: 102931979: 102940098 3785321:33840003 10017751:110023826 ENSG00000107077:KDM4C:chr9:+:6981841:6982765:698 ENSG00000157764:BRAF:chr7:- ENSGOOOOO 140474 :ULK3 : chr 15 : - 1118:6984165 :140434416:140434570:140426316:140439611 :75130492:75130514:75130139:75130606

ENSGOOOOO 126106 : TMEM53 :chrl : - ENSG00000138069:RABlA:chr2:- ENSG00000166411:IDH3A:chrl5:+:78449249:78449504:78 :45120611:45120881:45111136:45125845 :65325104:65325200:65315824:65357026 447593:78449889

ENSG00000079277:MKNK1 :chrl ENSG00000153391:IN080C:chrl8:- ENSG00000165629:ATP5Cl:chrl0:+:7848936:7848973:784

:47051545 :47051646:47049001 :47059784 :33059263:33059375:33058313:33077682 4817:7849621

ENSG00000169241 :SLC50A1 :chrl :+: 155109303: 15510942 ENSG00000157637:SLC38A10:chrl7:- ENSG00000171606:ZNF274:chrl9:+:58697063:58697205:5

7:155108852:155110036 :79223869:79223893:79220861:79225292 8695365:58698313

ENSG00000095637:SORBSl:chrl0:- ENSG00000203797:DDO:chr6:- ENSG00000119723 :COQ6:chrl4:+:74426117:74426225:744

:97131740:97131806:97127456:97135729 : 110734493 : 110734669: 110729645 : 110736669 25927:74427875

ENSG00000143797 :MBOAT2:chr2 : - ENSG00000147099:HDAC8:chrX:- ENSG00000073921 :PICALM:chrl 1 :-

: 9002400 :9002452: 9000894 :9002719 :71708782:71708891:71684581:71787738 :85687665:85687725:85670103:85692171

ENSG00000136717:BINl:chr2:- ENSG00000123349:PFDN5:chrl2:+:53690027:53690059:5 ENSG00000111554:MDMl:chrl2:-

: 127815048: 127815177: 127808819: 127816586 3689423:53691633 :68710360:68710390:68710033:68715126

ENSG00000181027:FKRP:chrl9:+:47251771:47251974:47 ENSG00000186635 : ARAP1 xhrll:- ENSG00000132600:PRMT7:chrl6:+:68381113:68381197:6

251345:47258668 :72443559:72443642:72438217:72463372 8380183:68386150

ENSG00000158062:UBXN11 :chrl :- ENSG00000076685:NT5C2:chrl0:- ENSG00000145730:PAM:chr5:+: 102363885: 102363942: 10

:26628184:26628213:26624553:26633082 : 104899162: 104899236: 104866463: 104934614 2361038:102364590

ENSG00000122203:KIAA1191:chr5> ENSG00000213995:NAXD:chrl3:+: 111274562: 111274713: ENSG00000135093:USP30:chrl2:+: 109495730: 109495913:

: 175786464: 175786570: 175779751 : 175786813 111267994:111286891 109494596:109505328

ENSG00000100350:FOXRED2:chr22:- ENSG00000198561:CTNNDl:chrll:+:57573932:57573950: ENSG00000125388:GRK4:chr4:+:3021367:3021558:301555

:36900144:36900414:36897454:36900561 57573507:57574386 5:3024140

ENSG00000139620:KANSL2:chrl2:- ENSG00000179912:R3HDM2:chrl2:- ENSG00000087274:ADDl:chr4:+:2911065:2911158:29103

:49072818:49072933:49065745:49073437 :57682791: 57682823: 57677839:57689181 31:2916610

ENSGOOOOO 196476 : C20orf96 :chr20 : - ENSG00000133884:DPF2:chrll:+:65112050:65112092:651 ENSG00000087085:ACHE:chr7:-

:270199:270317:264722:270899 11540:65113136 : 100489954: 100490264: 100488959: 100490785

ENSG00000167110:GOLGA2:chr9:- ENSG00000099864:PALM:chrl9:+:740351:740483:736078 ENSG00000111790:FGFR10P2:chrl2:+:27113447:2711356

: 131035063: 131035144: 131030803: 131036128 :746284 1:27110676:27116274

ENSG00000174628:IQCK:chrl6:+: 19746674: 19746772: 19 ENSG00000168958:MFF:chr2:+:228207460:228207535:22 ENSG00000135424 :ITGA7 :chrl2 : -

745149:19800159 8205096:228217229 :56094045:56094177:56093773:56094682

ENSG00000109756:RAPGEF2:chr4:+: 160164925: 1601649 ENSG00000116001 :TIA1 :chr2:- ENSG00000196387:ZNF140:chrl2:+: 133677572: 133677639

43:160162520:160225493 :70456190:70456223:70454954:70456395 : 133660147: 133682095

ENSG00000109083:IFT20:chrl7:- ENSG00000089159:PXN:chrl2:- ENSG00000100523:DDHDl:chrl4:-

:26659171:26659408:26659013:26662365 : 120654075: 120654919: 120653464: 120659425 :53560033:53560162:53558650:53570400

ENSG00000145725:PPIP5K2:chr5:+: 102518934: 10251910 ENSG00000132676:DAP3:chrl:+: 155706796: 155706854:1 ENSG00000077380:DYNClI2:chr2:+: 172569276: 17256933

8:102515889:102520372 55701824:155707947 6:172563887:172571837

ENSG00000087157:PGSl:chrl7:+:76411032:76411108:764 ENSG00000088367:EPB41Ll:chr20:+:34761685:34761876: ENSG00000102878:HSF4:chrl6:+:67203181:67203251:672 00170:76415626 34742818:34763472 03004:67203533

ENSG00000106351:AGFG2:chr7:+: 100154216: 100154249: ENSG00000141040:ZNF287:chrl7:- ENSG00000088367:EPB41Ll:chr20:+:34761685:34761876: 100153358:100159881 : 16470642: 16471243 : 16469936: 16472265 34700402:34763472

ENSG00000242588:RP11-

ENSG00000090857:PDPR:chrl6:+:70165204:70165322:70 ENSG00000135127:BICDLl:chrl2:+: 120510314: 12051053 274B21.14:chr7:+: 128220052: 128220148: 128218987: 12823

164447:70166053 3:120509605:120518690 1903

ENSG00000147099:HDAC8:chrX:- ENSG00000111711:GOLTlB:chrl2:+:21660050:21660085: ENSGOOOOO 187609 :EXD3 :chr9 :- :71715005:71715118:71684581:71787738 21659910:21661316 : 140269063 : 140269215 : 140268051 : 140277764 ENSG00000005436:GCFC2:chr2:- ENSG00000205362:MTlA:chrl6:+:56673175:56673241:56 ENSG00000049618:ARIDlB:chr6:+: 157495980: 157496139: :75919102:75919226:75917845:75921366 672678:56673770 157495251:157502102

ENSG00000112983:BRD8:chr5:- ENSG00000137501 : SYTL2:chrl 1 :- ENSGOOOOO 151612 :ZNF827 : chr4 : -

: 137502206: 137502416: 137501797: 137503622 :85425455: 85425550: 85422275:85429832 : 146791396: 146791630: 146770713: 146806829

ENSG00000145868:FBX038:chr5:+: 147806775: 14780751 ENSG00000175224:ATG13:chrll:+:46685546:46685645:4 ENSG00000157045:NTANl:chrl6:-

0:147805264:147812986 6681035:46686398 : 15141711:15141777: 15141407: 15149747

ENSG00000058404:CAMK2B:chr7:- ENSG00000164199:ADGRVl:chr5:+:90445846:90446038: ENSG00000072518:MARK2:chrll:+:63673559:63673586:6

:44272420:44272465:44270653:44273988 90398157:90459598 3672515:63675731

ENSG00000148481:MINDY3:chrl0:- ENSG00000157800:SLC37A3:chr7:- ENSG00000114416:FXRl:chr3:+: 180688862: 180688943: 18

: 15858833: 15858914: 15838171: 15863654 : 140045015: 140045063: 140037149: 140045668 0688146:180693100

ENSG00000243696:RP5-966M1.6:chr3:- ENSG00000134775:FHOD3:chrl8:+:33952642:33952707:3 ENSGOOOOO 139116 :KIF21 A: chrl 2 : -

: 52848224:52848379:52848087: 52850899 3935608:34081894 :39709733:39709772:39705355:39713707

ENSG00000102317:RBM3 :chrX:+:48434202:48434471 :48 ENSG00000196967:ZNF585A:chrl9:- ENSG00000103449:SALLl:chrl6:-

433671:48434701 :37656496: 37656598: 37647257:37660740 :51172598:51176056:51171463:51185076

ENSG00000179950:PUF60:chr8:- ENSG00000107317:PTGDS:chr9:+: 139873674: 139873853: ENSGOOOOO 143434 : SEMA6C: chrl : -

: 144906482: 144906566: 144904083 : 144911449 139872144:139874397 : 151108923: 151109055: 151108639: 151109332

ENSG00000165795:NDRG2:chrl4:- ENSG00000156860:FBRS:chrl6:+:30672624:30672654:306 ENSG00000095794:CREM:chrl0:+:35490378:35490414:35

:21491022:21491064:21490656:21491399 71763:30673740 484142:35495822

ENSG00000180900 : SCRIB :chr8: - ENSG00000103174:NAGPA:chrl6:- ENSG00000139372:TDG:chrl2:+: 104376913: 104376996: 10

: 144873835: 144873910: 144873610: 144874045 :5078297:5078399:5078186:5078880 4376712:104377072

ENSG00000124831:LRRFIPl:chr2:+:238647874:23864795 ENSG00000008441:NFIX:chrl9:+: 13189426: 13189549: 131 ENSG00000215908 : CR0CCP2 :chrl : -

2:238617273:238657006 86485:13192493 : 16952847: 16952994: 16952500: 16953639

ENSG00000112701 :SENP6:chr6:+:76350402:76350420:76 ENSG00000164548:TRA2A:chr7:- ENSG00000104529:EEFlD:chr8:-

344527:76357446 :23561750:23562051:23561459:23571407 : 144674816: 144675112: 144672251:144679517

ENSG00000175066:GK5:chr3:- ENSG00000186866 :POFUT2 :chr21 :- ENSG00000137965:IFI44:chrl:+:79126238:79126376:7912

: 141903552: 141904635: 141901891:141904770 :46685936:46686142:46685550:46687504 5168:79129449

ENSG00000067560:RHOA:chr3:- ENSG00000169220:RGS14:chr5 :+: 176798475 : 176798590: 1 ENSGOOOOO 137497 :NUM A1 : chr 11 : -

:49398360:49398499:49397815:49412866 76798397:176798873 :71723446:71723488:71721900:71723940

ENSGOOOOO 178104 :PDE4DIP :chrl : - ENSG00000182670:TTC3:chr21:+:38529462:38529516:385 ENSGOOOOO 105426 :PTPRS :chrl 9: -

: 144871695: 144871881: 144868172: 144873876 29208:38532000 :5218797:5218809:5218543:5219320

ENSG00000152749:GPR180:chrl3:+:95271403:95271584: ENSG00000150433:TMEM218:chrll:- ENSG00000168487:BMPl:chr8:+:22056776:22056900:2205

95264644:95271721 : 124972027 : 124972198: 124971199: 124972629 4933:22058630

ENSG00000168785:TSPAN5:chr4:- ENSG00000198176:TFDPl:chrl3:+: 114291934: 114292211: ENSG00000132530:XAFl:chrl7:+:6662574:6662838:66615

:99407888:99408035:99403326:99428828 114291015:114294434 43:6662980

ENSG00000171103:TRMT61B:chr2:- ENSG00000060339:CCARl:chrl0:+:70516029:70516240:7 ENSG00000136280:CCM2:chr7:+:45077851:45078025:450

:29087882:29087985 :29075365 :29092444 0515293:70517050 39962:45103516

ENSGOOOOO 105221 : AKT2 :chrl 9: - ENSG00000074964:ARHGEF10L:chrl:+: 17961042: 179610 ENSG00000186868:MAPT:chrl7:+:44049224:44049311:44

:40771128:40771258:40762961:40791087 57:17958961:17961329 039836:44055740

ENSG00000186812:ZNF397:chrl8:+:32834195:32834366: ENSG00000141391:PRELID3A:chrl8:+: 12420323: 1242049 ENSGOOOOO 107263 :RAPGEF 1 :chr9 : -

32823257:32837891 2:12408006:12421538 : 134480317: 134480575: 134477536: 134494437

ENSG00000105953:OGDH:chr7:+:44695916:44695961:44 ENSG00000116731 :PRDM2:chrl :+: 14095533 : 14095668: 14 ENSG00000117054:ACADM:chrl:+:76199212:76199313:7

687358:44706334 075982:14099572 6198607:76200475

ENSG00000101158:NELFCD:chr20:+:57568678:57568730 ENSG00000163964:PIGX:chr3:+: 196455572: 196455626: 19 ENSG00000112715 :VEGFA:chr6:+:43749692:43749789:43

:57568167:57569164 6455007:196457862 746655:43752277

ENSG00000143774:GUKl:chrl:+:228328824:228329208:2 ENSG00000049323:LTBPlxhr2:+:33567904:33568030:335 ENSGOOOOO 116670 :M AD2L2 xhrl : -

28328064:228333211 40336:33572433 : 11741095: 11741495: 11740670: 11751469

ENSG00000050820:BCARlxhrl6:- ENSG00000226210:ABC7- ENSG00000227232 : W ASH7P xhrl : -

:75271080:75271242:75269884:75276367 42389800N19.1xhrl2:+:87268:87367:78939:87556 : 17605: 17742: 17055: 17914

ENSG00000172530:BANP:chrl6:+:88008653:88008809:87 ENSG00000131375 :CAPN7xhr3:+: 15282959: 15283095: 15 ENSG00000250644 :RP11 -295K3.1 xhrl 1 :-

985121:88014641 282360:15283684 : 1768896: 1769349: 1756659: 1775032

ENSG00000186868:MAPT:chrl7:+:44087675:44087768:44 ENSG00000138162:TACC2xhrl0:+: 123972856: 123972892 ENSG00000146556:WASH2P:chr2:+: 114353644: 11435378

074030:44091608 : 123971223: 123974905 0:114353092:114353957

ENSG00000116698:SMG7:chrl:+: 183481971: 183482003:1 ENSG00000066651:TRMTllxhr6:+: 126327987: 12632810 ENSG00000159063:ALG8xhrll:- 83441784:183485008 0:126320759:126329537 :77849755:77849813:77838482:77850539

ENSG00000133318:RTN3:chrll:+:63472322:63472379:63 ENSG00000104613:INTS10xhr8:+: 19677889: 19678029: 19 ENSGOOOOO 168646 :AXIN2 xhrl 7 : -

449250:63517462 677187:19679949 :63532986:63533181:63532671:63533441

ENSG00000124596:OARDlxhr6:- ENSGOOOOO 133872 : S ARAF : chr8 : - ENSG00000160310:PRMT2xhr21:+:48056350:48056459:4

:41037814:41037873:41035176:41038870 :29931392:29931571:29927575:29940362 8055675:48056807

ENSG00000050767:COL23Alxhr5:- ENSG00000119650:IFT43xhrl4:+:76524984:76525017:76 ENSG00000165914:TTC7B:chrl4:-

: 177683866: 177683929: 177683398: 177684523 488737:76548637 :91069596:91069647:91059970:91077085

ENSG00000033100:CHPF2:chr7:+: 150933493: 150933676: ENSG00000114859:CLCN2xhr3:- ENSG00000099290:WASHC2A:chrl0:+:51851921:5185199

150932698:150934459 : 184071449: 184071583:184071210: 184071888 3:51851278:51853027

ENSG00000204580:DDRl:chr6:+:30853401:30853457:308 ENSG00000213742 :ZNF337- ENSG00000163681:SLMAP:chr3:+:57911571:57911661:57

48902:30856464 ASlxhr20:+:25655532:25655714:25654643:25657571 908750:57913022

ENSG00000089157:RPLP0xhrl2:- ENSG00000121310 :ECHDC2 xhrl : - ENSGOOOOO 169045 :HNRNPH 1 xhr5 : - : 120636356: 120636434: 120635265: 120636656 :53372190:53372283:53370505:53373539 : 179046269: 179046408: 179045324: 179047892 ENSG00000078018:MAP2:chr2:+:210372315:210372365:2 ENSG00000229117:RPL41xhrl2:+:56510558:56510714:56 ENSG00000103202:NME4xhrl6:+:448207:448394:447313: 10289000:210444759 510443:56511265 448989 ENSG00000110888:CAPRIN2xhrl2:- ENSG00000153250:RBMSlxhr2:- ENSG00000076984 :MAP2K7 xhrl 9 :+:7970692 :7970740 :79 :30906277:30906493:30904067:30907614 : 161138767: 161138815: 161137875: 161141285 68953:7974639 ENSG00000077157:PPPlR12B:chrl:+:202544129:2025443 ENSG00000198053:SIRPAxhr20:+: 1902040: 1902358: 1896 ENSGOOOOO 140307 :GTF2A2 xhrl 5 : - 10:202538325:202549601 101:1905409 :59944404:59944525: 59934461:59949604

ENSG00000166532:RIMKLB:chrl2:+:8932630:8932708:8 ENSGOOOOO 138606 : SHF xhrl5:- ENSG00000138614:INTS14xhrl5:-

930398:8933170 :45464344:45464516:45464200:45467416 :65899496:65899763:65897574:65903435

ENSG00000196295:AC005154.6xhr7:- ENSG00000165630:PRPF18xhrl0:+: 13639644: 13639671:1 ENSG00000186575:NF2xhr22:+:30079008:30079053:3007

:30591715:30591795:30590397:30601081 3639535:13642243 7590:30090740

ENSG00000135486:HNRNPAl:chrl2:+:54675578:5467572 ENSG00000049089 : COL 9A2 xhrl :- ENSGOOOOO 179912 :R3HDM2 xhrl 2 : -

5:54675286:54675873 :40780909:40781137:40780059:40781261 :57666235:57666337: 57663777:57674140

ENSG00000144647:POMGNT2 :chr3 : - ENSG00000023191 :RNH1 xhrl 1 :- ENSGOOOOO 187609 :EXD3 xhr9 :-

:43131979:43132101:43123028:43147327 :504823:504996:502181:507112 : 140249018: 140249225 : 140248829: 140250719

ENSG00000101040:ZMYND8xhr20:- ENSG00000131389: SLC6A6xhr3:+: 14509595: 14509720:1 ENSG00000214941 :ZSWIM7 xhrl 7 : -

:45841286:45841370:45839542:45848908 4509464:14513712 : 15880892: 15881227: 15880406: 15881357

ENSG00000122490:PQLClxhrl8:- ENSG00000126746 :ZNF384xhrl2:- ENSG00000059588:TARBP1 xhrl :-

:77679183:77679400:77664183:77703328 :6781515:6781698:6780004:6782381 :234534127:234534299:234529583:234536926

ENSG00000133816:MICAL2:chrll:+: 12277189: 12277297: ENSG00000169992:NLGN2xhrl7:+:7311330:7312031:730 ENSG00000183077:AFMIDxhrl7:+:76198783:76198832:7

12261132:12278331 8929:7315475 6187141:76202026

ENSG00000159445:THEM4:chrl:- ENSG00000102309:PIN4:chrX:+:71406083:71406384:7140 ENSG00000137965:IFI44:chrl:+:79126238:79126339:7912 : 151862458: 151862690: 151861849: 151867483 1678:71416634 5168:79128388 ENSG00000139613:SMARCC2:chrl2:- ENSG00000126214:KLCl:chrl4:+: 104153417: 104153548: ENSG00000168591 :TMUB2:chrl7:+:42265043 :42265111:4 : 56558086:56558152:56557549:56558431 104145882:104166991 2264477:42265274 ENSG00000071054:MAP4K4:chr2:+: 102487955: 10248814 ENSG00000025423:HSD17B6:chrl2:+:57156987:57157198 ENSG00000141552:ANAPCll:chrl7:+:79851427:79851490 7:102486877:102490108 :57146365:57167617 :79849709:79852342

ENSG00000242588:RP11-

ENSG00000140859:KIFC3:chrl6:- ENSG00000117859:OSBPL9:chrl:+:52205814:52205883:5 274B21.14:chr7:+: 128248171: 128248267: 128232071: 12825 : 57793036:57793065:57792821:57793639 2179751:52211207 5913 ENSG00000129675:ARHGEF6:chrX:- ENSG00000170919:TPT1- ENSG00000204580:DDRl:chr6:+:30852314:30852487:3084 : 135761693: 135761819: 135758876: 135762889 ASl:chrl3:+:45957225:45957370:45954136:45963869 8902:30856464 ENSG00000206503 :HLA- ENSG00000254901:BORCS8:chrl9:- ENSG00000101294:HM13:chr20:+:30155880:30156027:301 A:chr6:+:29912276:29912411:29912174:29912835 :19297701 : 19297814: 19293492:19302889 54098:30156922 ENSG00000135486:HNRNPAl:chrl2:+:54676862:5467701 ENSG00000095637:SORBSl:chrl0:- ENSGOOOOO 121897 :LIAS :chr4 :+: 39466904 :39466962 :3946 8:54676658:54677595 :97131082:97131184:97127456:97135729 5225:39469137

ENSG00000140416:TPMl:chrl5:+:63356262:63356389:63 ENSG00000084207:GSTPl:chrll:+:67351604:67351640:67 ENSG00000092871 :RFFL :chrl7 :-

354844:63358094 351315:67352155 :33348389:33348800: 33344625:33353392

ENSG00000167081:PBX3 :chr9:+: 128724380: 128724493 :1 ENSG00000168301:KCTD6:chr3:+:58479879:58480135:58 ENSG00000196263:ZNF471:chrl9:+:57027643:57027770:5 28723128:128725290 477896:58484439 7022973:57029850

ENSG00000168005:Cllorf84:chrll:+:63585998:63586124: ENSG00000067066:SP100:chr2:+:231314886:231314970:2 ENSGOOOOO 148290 : SURF 1 :chr9 :-

63585837:63586273 31313865:231325976 :136223123:136223175:136221596:136223275

ENSG00000168096:ANKS3:chrl6:- ENSG00000160226:C21orf2:chr21:- ENSG00000215908 : CR0CCP2 :chrl : -

:4781512:4781580:4780152:4784156 :45753943:45755687:45753145:45757531 : 16959589: 16959841: 16958866: 16961521

ENSG00000088298:EDEM2:chr20:- ENSG00000231584:FAHD2CP:chr2:+:96685285:96685448: ENSG00000089472:HEPH:chrX:+:65474876:65474983:654

: 33722540:33722752:33714178: 33725682 96681073:96686872 28088:65478681

ENSG00000146112:PPPlR18:chr6:- ENSG00000109339:MAPK10:chr4:- ENSG00000062194:GPBPl:chr5:+:56532939:56532999:565

:30652184:30652321:30647166:30654890 :87019676:87020438:86989108:87022204 31859:56542126

ENSG00000116641 :D0CK7 :chrl :- ENSG00000119929:CUTC:chrl0:+: 101510125: 101510153: ENSGOOOOO 122203 :KIAA1191 :chr5

:63010617:63010710:63009416:63018402 101507147:101514285 : 175782573: 175782752: 175779751:175788604

ENSG00000005884:ITGA3:chrl7:+:48165588:48165730:4 ENSG00000169241:SLC50Al:chrl:+: 155110036: 15511019 ENSG00000183077:AFMID:chrl7:+:76201683:76201819:7

8165233:48166473 8:155108852:155110454 6201599:76202026

ENSG00000169231:THBS3:chrl:- ENSG00000005243:COPZ2:chrl7:- ENSG00000064655:EYA2:chr20:+:45702796:45702974:456

: 155165777: 155165917: 155165690: 155166831 :46105041:46105155:46103841:46106490 44936:45717877

ENSG00000168958:MFF:chr2:+:228195310:228195562:22 ENSG00000163482:STK36:chr2:+:219553113:219553216:2 ENSGOOOOO 198369: SPRED2 :chr2 :-

8190143:228197134 19549951:219553419 :65561738:65561907:65559185:65571852

ENSG00000258461:RP11- ENSG00000163608:NEPRO:chr3:- ENSG00000101639:CEP192:chrl8:+: 13103873: 13103966:1

164J13.1:chrl5:+:42700408:42700522:42695975:42701500 : 112729489: 112729551 : 112727277: 112729891 3103587:13104982

ENSG00000182272:B4GALNT4:chrll:+:380670:380951:3 ENSG00000028203:VEZT:chrl2:+:95650325:95650398:95 ENSG00000108064:TFAM:chrl0:+:60150524:60150620:60

80445:381668 645847:95650925 148579:60154117

ENSG00000124275:MTRR:chr5:+:7873485:7873625:78710 ENSG00000108848:LUC7L3:chrl7:+:48826579:48826705: ENSG00000171634:BPTF:chrl7:+:65959448:65959622:659

36:7875370 48825777:48827861 55991:65960327

ENSG00000214941:ZSWIM7:chrl7:- ENSG00000077522:ACTN2:chrl:+:236890977:236891056: ENSG00000125676:THOC2:chrX:- : 15881113: 15881227: 15880406: 15881357 236889320:236894532 : 122757494: 122757560: 122757134: 122757637

ENSG0000011923 l:SENP5:chr3:+: 196654666: 196654750: ENSG00000159596:TMEM69:chrl:+:46156645:46156782: ENSG00000081377:CDC14B:chr9:- 196650422:196656503 46153947:46158875 :99277930:99278074:99272071:99284787 ENSGOOOOO 168970 : JM1D7-

ENSG00000162813:BPNTl:chrl:- ENSG00000145868:FBX038:chr5:+: 147806775: 147807285 PLA2G4B:chrl5:+:42135323:42135421:42134789:4213587 :220253068:220253196:220247413:220263027 : 147805264: 147812986 3 ENSG00000104852:SNRNP70:chrl9:+:49605370:4960543 ENSG00000006634:DBF4:chr7:+:87533606:87533731:8753 ENSG00000165055:METTL2B:chr7:+: 128118002: 1281180 0:49604728:49607890 0193:87536502 46:128117227:128119211

ENSG00000156958:GALK2:chrl5:+:49575762:49575915:4 ENSG00000095637:SORBSl:chrl0:- ENSG00000270249 :RP 11 -514P8.7 : chr7 : -

9531564:49584523 :97131082:97131184:97127456:97141441 : 102207028: 102207183: 102182109: 102207443

ENSG00000124222:STX16:chr20:+:57246219:57246353:5 ENSG00000139624:CERS5:chrl2:- ENSG00000159761:C16orf86:chrl6:+:67701129:67701428:

7245659:57248686 :50529215:50529435:50528485:50529514 67700975:67701780

ENSG00000144744:UB A3 :chr3 :- ENSG00000169045:HNRNPHl:chr5:- ENSG00000126777:KTNl:chrl4:+:56068474:56068598:560

:69124580:69124661:69120768:69126948 : 179045145: 179045324: 179044912: 179047892 47072:56078736

ENSG00000174099:MSRB3:chrl2:+:65702308:65702435:6 ENSG00000205531 :NAPlL4:chrl 1 :- ENSG00000205571:SMN2:chr5:+:69372347:69372401:693

5672645:65720605 :2970456:2970494:2966876:2972488 66578:69372845

ENSG00000133226:SRRMl:chrl:+:24973569:24973699:24 ENSG00000073536:NLEl:chrl7:- ENSGOOOOO 127481 :UBR4 :chrl : -

973280:24975349 :33466838: 33467085: 33466333:33468997 : 19476256 : 19476289 : 19475120 : 19477070

ENSG00000101294:HM13:chr20:+:30155880:30156083:30 ENSG00000283886:RPll-204M4.3:chr9:- ENSG00000079337:RAPGEF3:chrl2:-

154098:30156922 :41975030:41975128:41963942:42018927 :48134424:48134606:48134178:48134697

ENSG00000070814:TCOFl:chr5:+: 149771106: 149771358: ENSG00000070718:AP3M2:chr8:+:42011995:42012054:42 ENSGOOOOO 196776 : CD47 :chr3 : -

149769586:149771519 010623:42012133 : 107768465 : 107768498: 107766139: 107776323

ENSG00000184271:POU6Fl:chrl2:- ENSG00000136699:SMPD4:chr2:- ENSG00000061938 :TNK2 :chr3 : -

:51585378:51585547:51584375:51586112 : 130918758: 130918845: 130914969: 130921946 : 195596367: 195596412: 195595580: 195596984

ENSG00000196295:AC005154.6:chr7:- ENSG00000067225 :PKM:chrl 5 : - ENSG00000110888:CAPRIN2:chrl2:-

:30618621:30618744:30617707:30618846 :72495362:72495529:72492996:72499068 :30872012:30872159:30869610:30876192

ENSG00000133612:AGAP3:chr7:+: 150817606: 150817832: ENSG00000122481 :RWDD3 :chrl :+:95712097:95712213 :9 ENSG00000121716:PILRB:chr7:+:99951517:99951635:999

150817232:150819811 5699871:95712311 51106:99952765

ENSGOOOOO 198276 :UCKL 1 :chr20: - ENSG00000132470:ITGB4:chrl7:+:73751135:73751294:73 ENSG00000084693 : AGBL5 :chr2 :+:27291915 :27291962 :27

:62575005:62575022:62573845:62575749 750896:73751781 291612:27292440

ENSG00000181929:PRKAGl:chrl2:- ENSG00000184182:UBE2F:chr2:+:238903385:238903451: ENSG00000166839:ANKDDlA:chrl5:+:65219099:6521919

:49399525:49399664:49399326:49406844 238881867:238933982 8:65218369:65223019

ENSGOOOOO 122482 :ZNF644 :chrl :- ENSG00000196323:ZBTB44:chrll:- ENSG00000196586 :MY06 :chr6 :+:76604947 :76604977 :766

:91403041:91403647:91383711:91447866 : 130130750: 130131824: 130109791: 130184269 02407:76608089

ENSG00000168175:MAPKlIPlL:chrl4:+:55528397:55528 ENSG00000175061 :LRRC75A- ENSG00000070808 :CAMK2A:chr5 : -

419:55518521:55529335 ASl:chrl7:+: 16342894: 16343017: 16342728: 16343498 : 149607754: 149607849: 149602780: 149618262

ENSG00000172366:MCRIP2:chrl6:+:696471:696608:6920 ENSG00000122490:PQLCl:chrl8:- ENSG00000115504 :EHBPl:chr2:+:63176228:63176297:631

43:697416 :77679183 :77679400:77664183 :77693968 75451:63182651

ENSG00000162341:TPCN2:chrll:+:68852677:68852754:6 ENSG00000144857:BOC:chr3:+: 112991915: 112992188: 11 ENSG00000196118:CCDC189:chrl6:-

8851484:68902902 2991550:112993221 :30770498:30770568:30768975:30771604

ENSG00000125454:SLC25A19:chrl7:- ENSG00000164818:DNAAF5:chr7:+:819589:819781:81479 ENSGOOOOO 114268 :PFKFB4 :chr3 :- :73273433:73273564:73269720:73279503 9:825153 :48562997:48563102:48561263 :48572944 ENSG00000104852:SNRNP70:chrl9:+:49605370:4960544 ENSG00000124788:ATXNl:chr6:- ENSG00000181027:FKRP:chrl9:+:47251771:47251922:472 2:49604728:49607890 : 16753463: 16753578: 16658132: 16761528 51345:47258668

ENSG00000137726:FXYD6:chrll:- ENSGOOOOO 122085 :MTERF4 : chr2 : - ENSG00000154930:ACSSl:chr20:-

: 117711058: 117711083: 117710545: 117711862 :242033691:242033844:242029459:242036657 :25000645 :25000783 :24995866:25011394

ENSG00000130590:SAMD10:chr20:- ENSG00000105538:RASIPl:chrl9:- ENSG00000075413:MARK3:chrl4:+: 103966492: 10396653

:62609597:62609714:62608759:62611206 :49230041:49230145:49228217:49232193 7:103958371:103969218

ENSG00000127483 :HP1BP3 :chrl :- ENSG00000133816:MICAL2:chrll:+: 12277189: 12277297: ENSG00000130988:RGN:chrX:+:46939715:46940335:4693

:21106842:21107033:21106404:21113687 12270793:12278331 8108:46940528

ENSG00000145349:CAMK2D:chr4:- ENSG00000029363 :BCLAF1 :chr6:- ENSG00000059769:DNAJC25:chr9:+: 114405136: 11440537

: 114376881: 114376977: 114375671: 114378490 : 136597605: 136597646: 136597127: 136599002 4:114394023:114409386

ENSG00000103148:NPRL3:chrl6:- ENSG00000212694:LINC01089:chrl2:- ENSG00000067113 :PLPP 1 : chr5 : -

: 180520: 180590: 162774: 188148 :122240536:122240712:122239714:122240784 :54786787:54786942: 54763977:54830399

ENSG00000133612:AGAP3:chr7:+: 150817606: 150817832: ENSG00000106052:TAXlBPl:chr7:+:27855967:27856139: ENSG00000147364:FBX025:chr8:+:382885:382935:38144 150817232:150820880 27839709:27867356 4:385614 ENSG00000007376:RPUSDl:chrl6:- ENSGOOOOO 164347 : GFM2 : chr5 : - ENSG00000072518:MARK2:chrll:+:63675731:63675776:6 :837076:837179:836928:837353 :74034326:74034467:74034242:74035813 3673586:63676348

ENSG00000134769:DTNA:chrl8:+:32418708:32418801:32 ENSG00000124787:RPP40:chr6:- ENSG00000005448:WDR54:chr2:+:74649246:74649502:74

409453:32428259 :4998949:4999075:4996654:5000042 648943:74649996

ENSG00000131778:CHDlL:chrl:+: 146751698: 146751864: ENSG00000174628:IQCK:chrl6:+: 19775356: 19775434: 197 ENSGOOOOO 188906 :LRRK2:chrl2:+:40707773 :40707975 :4 146747921:146757000 45149:19800159 0704451:40709013 ENSG00000257621 :PSMA3 -AS 1 :chrl4 :- ENSG00000119688:ABCD4:chrl4:- ENSGOOOOO 164751 :PEX2 :chr8 : - : 58759783:58759856:58758425:58764672 :74756729:74756821:74756222:74756993 :77900542:77900574:77896431:77912225 ENSG00000159761:C16orf86:chrl6:+:67701198:67701428: ENSG00000122490:PQLCl:chrl8:- ENSGOOOOO 197119 : SLC25 A29 : chrl 4 : - 67700975:67701780 :77693968:77694022:77664183:77703328 : 100761962: 100762330: 100759714: 100765178

ENSG00000148842:CNNM2:chrl0:+: 104831530: 10483159 ENSG00000284024 :RP11- ENSG00000145214:DGKQ:chr4:-

6:104828479:104835842 398C13.8:chrl0:+: 14884132: 14884845: 14882156: 14885369 :957860:957881:957078:958963

ENSG00000106070:GRB10:chr7:- ENSG00000007541:PIGQ:chrl6:+:631198:631341:630972: ENSG00000120860:WASHC3:chrl2:-

:50772836:50773020:50771605:50823583 632882 : 102443966: 102444069: 102439897 : 102455689

ENSG00000146112:PPPlR18:chr6:- ENSG00000197381:ADARBl:chr21:+:46604388:46604508 ENSG00000198556:ZNF789:chr7:+:99081652:99081766:99

:30652184:30653823:30647166:30654890 :46603425 :46604837 077410:99084098

ENSG00000100842:EFS:chrl4:- ENSG00000128891:C15orf57:chrl5:- ENSG00000143409:MINDYl:chrl:-

:23829763:23830042:23829490:23834216 :40845793 : 40846326:40824501 :40849414 : 150974640: 150974876: 150974258: 150978787

ENSG00000065882:TBClDl:chr4:+:38054726:38054846:3 ENSG00000110888:CAPRIN2:chrl2:- ENSG00000172661:WASHC2C:chrl0:+:46272720:4627287

8053681:38055819 :30873744:30873849:30869610:30876192 3:46268806:46274400

ENSG00000279457:RP11-

ENSG00000176155:CCDC57:chrl7:- ENSG00000133627:ACTR3B:chr7:+: 152497615: 15249774 34P13.18:chr2:+: 114352626: 114352738: 114346280: 114352 :80136349:80136481:80130736:80141649 0:152480327:152498705 945 ENSG00000147576:ADHFEl:chr8:+:67352396:67352434:6 ENSG00000181038:METTL23:chrl7:+:74725771:7472587 ENSG00000169727:GPSl:chrl7:+:80010134:80010335:800 7344810:67356601 6:74722961:74729059 09840:80011149 ENSG00000060138:YBX3:chrl2:- ENSG00000174796:THAP6:chr4:+:76465068:76465169:76 ENSG00000129116:PALLD:chr4:+: 169846383: 169846429: : 10862506:10862713 :10856747: 10865809 447071:76467618 169846229:169847363 ENSG00000058063 : ATP1 IB :chr3 :+: 182620268 : 182620354 ENSG00000103121:CMC2:chrl6:- ENSG00000214078:CPNEl:chr20:- : 182616560: 182631648 :81030918:81031034:81010076:81040338 :34243123:34243266:34220845:34252723

ENSG00000137842:TMEM62:chrl5:+:43470804:43470909 ENSG00000047932:GOPC:chr6:- ENSG00000148498:PARD3:chrl0:- :43461875:43473378 : 117898610: 117898634: 117896515: 117900062 :34573062:34573173 :34420511 :34606034

ENSG00000124313:IQSEC2:chrX:- ENSG00000196295:AC005154.6:chr7:- ENSG00000085978:ATG16Ll:chr2:+:234182366:23418242 :53308745:53308958:53296246:53310677 :30601081 :30601744:30590397:30608448 3:234181698:234183321 ENSG00000107679:PLEKHAl:chrl0:+: 124187791: 124187 ENSG00000065526:SPEN:chrl:+: 16202696: 16203173: 1619 ENSG00000143549 :TPM3 :chrl :- 832:124186547:124189139 9631:16235815 : 154141780: 154141859: 154130197: 154142875

ENSG00000160325:CACFDl:chr9:+: 136330443: 13633056 ENSG00000180098:TRNAUlAP:chrl:+:28887624:2888777 ENSG00000133256:PDE6B:chr4:+:661644:661795:660403:

9:136328677:136333042 2:28887244:28887857 663834

ENSG00000087085:ACHE:chr7:- ENSG00000081692:JMJD4:chrl:- ENSG00000163528 : CHCHD4 : chr3 : -

: 100489954: 100490175: 100488959: 100490785 :227920629:227920728:227920377:227921114 : 14163416: 14163586: 14158024: 14166154

ENSG00000140995:DEF8:chrl6:+:90015824:90015921:90 ENSG00000168961:LGALS9:chrl7:+:25970550:25970646: ENSGOOOOO 153391 :INO80C : chrl 8 : -

015222:90021576 25969374:25972339 :33067349:33067403:33060527:33077682

ENSG00000167522:ANKRDll:chrl6:- ENSG00000078487:ZCWPWl:chr7:- ENSGOOOOO 118194 :TNNT2 : chrl : - : 89352446:89352594:89341599: 89354935 : 100006161 : 100006282: 100004421 : 100007050 :201338943:201338973:201337355:201341154 ENSG00000152061:RABGAPlL:chrl:+: 174957777: 17495 ENSG00000119950:MXI1 :chrl0:+: 112004585: 112004631: 1 ENSG00000101190:TCFL5:chr20:- 7975 : 174952042: 174958985 11988079:112038937 :61488746:61488990:61485509:61491476

ENSG00000152154:TMEM178A:chr2:+:39934188:399343 ENSG00000059145:UNKL:chrl6:- ENSG00000178053:MLFl:chr3:+: 158306640: 158306713: 15

26:39893514:39944149 : 1463846: 1464010: 1453345: 1464615 8289136:158310222

ENSG00000167978:SRRM2:chrl6:+:2818505:2818600:281 ENSG00000002919:SNXll:chrl7:+:46188069:46188129:4 ENSG00000196914:ARHGEF12:chrll:+: 120300420: 12030

8262:2818997 6185200:46189392 0540:120300226:120302479

ENSG00000139631:CSAD:chrl2:- ENSG00000133943:C14orfl59:chrl4:+:91614124:9161420 ENSG00000006282:SPATA20:chrl7:+:48625080:48625128

: 53565109:53565225:53564286: 53565665 2:91580872:91623982 :48624646:48625643

ENSG00000010803:SCMHl:chrl:- ENSG00000143774:GUKl:chrl:+:228336071:228336240:2 ENSG00000139793:MBNL2:chrl3:+:98018712:98018807:9

:41625396:41625605:41617356:41626546 28335400:228336365 8009889:98043575

ENSG00000198399:ITSN2:chr2:- ENSG00000147100:SLC16A2:chrX:+:73749047:73749276: ENSG00000196873:CBWD3:chr9:+:70871836:70871896:70

:24507631:24507712:24498718:24509080 73745728:73751167 863813:70873447

ENSG00000095637:SORBSl:chrl0:- ENSG00000135723:FHODl:chrl6:- ENSG00000138709:LARPlB:chr4:+: 129131010: 129131148

:97096277:97097051:97081778:97098889 :67270313 :67270337:67268375 :67270459 : 129128538: 129141509

ENSG00000084234:APLP2:chrll:+: 129993506: 129993674 ENSG00000143951:WDPCP:chr2:- ENSG00000120860:WASHC3:chrl2:-

: 129992408: 129996594 :63380629:63380709:63380080:63401804 : 102455025: 102455124: 102444069: 102455689

ENSG00000166949:SMAD3:chrl5:+:67457590:67457722: ENSGOOOOO 101190 : TCFL5 : chr20 : - ENSGOOOOO 132694 : ARHGEF 11 :chrl :-

67457426:67459116 :61490715:61490878:61473449:61491476 : 156941488: 156941608: 156939835: 156946774

ENSG00000159346: ADIPOR1 :chrl :- ENSG00000124222:STX16:chr20:+:57234678:57234690:57 ENSG00000145730:PAM:chr5:+: 102363888: 102363942: 10

:202923368:202923435:202920292:202927312 227143:57242545 2361038:102364590

ENSG00000143537:ADAM15:chrl:+: 155034379: 15503459 ENSG00000185189:NRBP2:chr8:- ENSG00000177410:ZFASl:chr20:+:47897439:47897501:47

3:155033308:155034720 : 144917989: 144918045: 144917900: 144918136 897107:47905581

ENSG00000266173:STRADA:chrl7:- ENSG00000125733:TRIP10:chrl9:+:6746039:6746207:674 ENSG00000147576:ADHFEl:chr8:+:67352396:67352434:6

:61800657:61800686:61791468:61803997 5005:6746462 7344810:67355032

ENSG00000160094:ZNF362:chrl:+:33736087:33736213:3 ENSG00000172766:NAA16:chrl3:+:41936866:41937009:4 ENSGOOOOO 174606 : ANGEL2 :chrl : -

3722255:33741700 1936295:41941574 :213174127:213174254:213173725:213178374

ENSG00000141378:PTRH2:chrl7:- ENSG00000134905:CARS2:chrl3:- ENSG00000181027:FKRP:chrl9:+:47251771:47252141:472

:57776231:57777550:57775339:57784731 : 111350264: 111350314:111340365 : 111353784 51345:47258668

ENSG00000102984:ZNF821:chrl6:- ENSG00000156976:EIF4A2:chr3:+: 186502750: 186502890: ENSG00000272888:LINC01578:chrl5:+:93426814:9342700

:71895678:71895845:71894575:71898040 186502485:186503671 8:93426416:93428744

ENSG00000257103:LSM14A:chrl9:+:34717312:34717369: ENSG00000196312:MFSD14C:chr9:- ENSG00000168958:MFF:chr2:+:228211941:228212100:228 34712643:34718269 :99735134:99735230:99721179:99775540 207535:228220392

ENSG00000143774:GUKl:chrl:+:228329326:228329530:2 ENSG00000206562:METTL6:chr3:- ENSG00000198722:UNC13B:chr9:+:35364541:35364564:3 28328989:228333211 :15457004: 15457090: 15456421 :15457278 5313986:35366943

ENSG00000244560 :RP4-

ENSG00000162735:PEX19:chrl:- ENSG00000111711:GOLTlB:chrl2:+:21659818:21659910: 800G7.2:chr7:+: 148986638: 148986817: 148986548: 1489870

: 160253319: 160253429: 160252899: 160254844 21654882:21665228 28

ENSG00000019144:PHLDBl:chrll:+: 118515364: 1185154 ENSG00000085978:ATG16Ll:chr2:+:234182636:23418268 ENSG00000166169:POLL:chrl0:-

09:118514892:118516073 7:234182423:234183321 : 103345618: 103345913: 103340173: 103347002

ENSG00000054277:OPN3 :chrl :- ENSG00000163697:APBB2:chr4:- ENSG00000139496:NUP58:chrl3:+:25911073:25911172:25

:241767561:241767881:241761299:241803183 :40937093:40937156:40936716:40946881 905696:25912773

ENSG00000079156:OSBPL6:chr2:+: 179188903: 179188996 ENSG00000165868:HSPA12A:chrl0:- ENSG00000127603:MACFl:chrl:+:39930766:39930784:39

: 179171013: 179192982 : 118441301: 118441388: 118440767: 118443301 929358:39934286

ENSG00000037474:NSUN2:chr5:- ENSG00000104218:CSPPl:chr8:+:68062017:68062170:680 ENSG00000138468: SENP7 :chr3 :-

:6622128:6622213:6620411:6623326 49838:68066258 : 101117704: 101117899: 101090970: 101136436

ENSG00000087085:ACHE:chr7:- ENSG00000129103:SUMF2:chr7:+:56142278:56142332:56 ENSG00000104067:TJPl:chrl5:-

: 100490307: 100490439: 100488959: 100490785 141911:56144526 :30011980:30012220:30011342:30012561

ENSG00000138674:SEC31A:chr4:- ENSG00000115355:CCDC88A:chr2:- ENSGOOOOO 138794 :CASP6 :chr4 :-

: 83782783:83782861:83778917: 83784470 :55530204:55530288:55529208:55535944 : 110617565: 110617642: 110615856: 110618777

ENSG00000139620:KANSL2:chrl2:- ENSG00000130731:METTL26:chrl6:- ENSGOOOOO 197119 : SLC25 A29 : chrl 4 : -

:49072818:49073021:49065745:49073437 :685611 :685774:684797:686093 : 100761962: 100762034: 100759714: 100765178

ENSG00000135390:ATP5G2:chrl2:- ENSG00000047849:MAP4:chr3:- ENSG00000229180 : GS 1 -124K5.12 :chr7 : -

:54063654:54063898:54059212:54066359 :47910703:47910817:47899002:47912302 :66041741:66041916:66038537:66053498

ENSG00000173947:PIFO:chrl :+: 111890295 : 111890394: 11 ENSG00000093167 :LRRFIP2 :chr3 : - ENSG00000204371 :EHMT2 : chr6 : -

1889671:111892727 :37114280:37114373:37107433:37116514 :31856745:31856847:31856524:31857004

ENSG00000078618:NRDC:chrl:- ENSG00000112983 :BRD8:chr5:- ENSG00000076685:NT5C2:chrl0:-

:52302040:52302110:52301884:52305897 : 137502206: 137502299: 137501797: 137503622 : 104860419: 104860700: 104859776: 104860801

ENSG00000005448:WDR54:chr2:+:74649279:74649502:74 ENSGOOOOO 113240 : CLK4 :chr5:- ENSG00000130751:NPASl:chrl9:+:47544282:47544383:47

648943:74649996 : 178046838: 178047674: 178045779: 178050256 543808:47546067

ENSG00000136280:CCM2:chr7:+:45111348:45111471:451 ENSG00000038002 : AGA:chr4 :- ENSG00000254901 :B0RCS8 :chrl 9:- 09560:45112324 : 178357429: 178357505: 178355643: 178358558 : 19296842: 19296907: 19293492: 19302889

ENSG00000213199:ASIC3:chr7:+: 150748258: 150748406:1 ENSG00000112357:PEX7:chr6:+: 137193335: 137193391: 13 ENSG00000169727:GPSl:chrl7:+:80010131:80010335:800

50748182:150748896 7147607:137219279 09840:80011149

ENSG00000156504:FAM122B:chrX:- ENSG00000095574:IKZF5:chrl0:- ENSG00000203761:MST02P:chrl:+: 155717767: 155717918

: 133906172: 133906313: 133905384: 133915850 : 124766541 : 124766692: 124758187 : 124768209 : 155717687: 155718190

ENSG00000122678:POLM:chr7:- ENSG00000169764:UGP2:chr2:+:64069672:64069733:640 ENSG00000135097:MSIl:chrl2:-

:44113729:44114129:44113624:44118338 69571:64083439 : 120789146: 120789203: 120785317: 120791101

ENSG00000118900:UBNl:chrl6:+:4921155:4921302:4920 ENSG00000048544:MRPS10:chr6:- ENSG00000166169:POLL:chrl0:-

973:4922884 :42181857:42181930:42179655:42182017 : 103345618: 103345913: 103342648: 103347002

ENSG00000231064:RP11-

ENSG00000102317:RBM3 :chrX:+:48434309:48434471 :48 263K19.4:chrl:+: 155168193: 155168409: 155166808: 155169 ENSGOOOOO 198563 :DDX39B :chr6 :- 434055:48434701 962 :31508929:31509104:31508311:31509726

ENSG00000112659:CUL9:chr6:+:43154697:43154833:431 ENSGOOOOO 196821 : C6orfl 06 xhr6 : - ENSGOOOOO 196792 : STRN3 xhrl 4 : - 54193:43154983 :34614377:34614575:34574681:34622401 :31398406:31398517:31382863:31404368

ENSG00000070010 :UFD 1L : chr22 : - ENSG00000108387:SEPT4xhrl7:- ENSG00000172775:FAM192Axhrl6:-

: 19462590:19462623 :19459331 : 19466605 :56604042:56604339:56603674:56609321 :57212413:57212764:57207781:57219942

ENSG00000213614:HEXA:chrl5:- ENSG00000167491:GATAD2A:chrl9:+: 19612777: 1961285 ENSGOOOOO 152952 :PL0D2 :chr3 :-

:72645408:72645519:72643575:72647899 2:19612225:19613139 : 145795648: 145795711:145794682: 145796902

ENSG00000132589:FLOT2xhrl7> ENSGOOOOO 106077 : ABHD 11 : chr7 : - ENSG00000114948:ADAM23:chr2:+:207474633:20747472

:27212874:27212965:27211333:27215962 :73151550:73151721:73151021:73151891 4:207460886:207482302

ENSGOOOOO 160767:FAM189Bxhrl:- ENSG00000126457:PRMTlxhrl9:+:50183128:50183182:5 ENSG00000162241:SLC25A45xhrll:-

: 155223874: 155223985: 155223523: 155224190 0180573:50185166 :65146846:65147032:65144547:65147337

ENSG00000115414:FNl:chr2:- ENSG00000163138:PACRGL:chr4:+:20715054:20715162:2 ENSG00000136717:BINlxhr2:-

:216236831:216237098:216236738:216238044 0706437:20728907 : 127808729: 127808819: 127808488: 127816586

ENSG00000103174:NAGPA:chrl6:- ENSG00000112851 :ERBINxhr5:+:65370851:65371058:65 ENSG00000126777:KTNl:chrl4:+:56130672:56130759:561

:5078297:5078366:5078186:5078880 350779:65372143 28330:56137446

ENSG00000196712:NFl:chrl7:+:29694242:29694296:2968 ENSG00000116731 :PRDM2xhrl :+: 14095612: 14095668:14 ENSG00000133794:ARNTL:chrll:+: 13376779: 13376843:1

7721:29701030 075982:14099572 3375995:13378285

ENSG00000133816:MICAL2:chrll:+: 12270730: 12270793: ENSG00000078674:PCMlxhr8:+: 17792214: 17792367: 177 ENSG00000117859:OSBPL9:chrl:+:52221991:52222030:52 12261132:12277189 82289:17793097 215867:52226361

ENSG00000086666:ZFAND6xhrl5:+:80390757:80390920: ENSG00000151092 :NGLY1 xhr3 : - ENSG00000204954:C12orf73xhrl2:-

80352151:80412669 :25761504:25761682:25761126:25770623 : 104347191: 104347312: 104345408: 104350408

ENSG00000077232:DNAJC10:chr2:+: 183604271: 1836044 ENSG00000132781 :MUTYHxhrl :- ENSG00000108599:AKAP10xhrl7:- 36:183601113:183605025 :45795560:45795740:45795109:45796187 : 19844199: 19844323: 19843162: 19845138 ENSG00000163939:PBRMlxhr3:- ENSG00000103197:TSC2xhrl6:+:2132436:2132505:21317 ENSG00000156873:PHKG2:chrl6:+:30762869:30762924:3 : 52588739:52588895:52584833: 52595782 99:2133695 0762538:30764552

ENSG00000239969 :RP11 -

ENSG00000143416 : SELENBP 1 xhr 1 : - 163E9.2xhr7:+: 102006464: 102006523: 102004858: 1020162 ENSG00000177192:PUSl:chrl2:+: 132423717: 132423820:1 : 151341917: 151342030: 151340795: 151342188 69 32416857:132425836 ENSG00000126457:PRMTl:chrl9:+:50183128:50183182:5 ENSG00000170954:ZNF415xhrl9:- ENSG00000149577:SIDT2:chrll:+: 117057705: 117057717: 0180573:50183743 :53618462:53618560:53613161:53619565 117057352:117058093

ENSG00000163719:MTMR14:chr3:+:9719667:9719742:97 ENSG00000137700:SLC37A4xhrll:- ENSGOOOOO 110066 :KMT5B xhrl 1 : -

19071:9724861 : 118896401: 118896467: 118896039: 118896676 :67946936:67947004:67942650:67947598

ENSG00000204387 :C6orf48 :chr6 :+: 31804071:31804294 : 31 ENSG00000118454:ANKRD13Cxhrl:- ENSG00000148019:CEP78xhr9:+:80880774:80880822:808

803228:31805012 :70736538:70736639:70728530:70740402 80459:80881357

ENSG00000135250:SRPK2:chr7:- ENSG00000072210 :ALDH3A2 xhrl7 :+: 19576463 : 1957658 ENSG00000124193:SRSF6xhr20:+:42087792:42088060:42

: 104909252: 104909316: 104844232: 105029094 8:19575269:19578808 087149:42088410

ENSG00000073008:PVR:chrl9:+:45162009:45162168:451 ENSG00000060069 : CTDP1 xhrl 8 :+:77488906 :77489069 :7 ENSG00000205758:CRYZLlxhr21:-

57286:45164558 7478016:77513651 :35013484:35013611:35003863:35013986

ENSG00000213995:NAXD:chrl3 :+: 111279785: 111279894 ENSG00000112715 :VEGFA:chr6:+:43749692:43749824:43 ENSG00000005801:ZNF195xhrll:- : 111267994: 111286891 746655:43752277 :3382972:3383119:3381795:3392204

ENSG00000171307:ZDHHC16:chrl0:+:99213555:9921360 ENSG00000241343:RPL36AxhrX:+: 100647037: 10064708 ENSG00000095637:SORBSlxhrl0:- 3:99213420:99214470 3:100646810:100650322 :97131082:97131184:97127456:97131740 ENSGOOOOO 146067:FAM193Bxhr5:- ENSG00000166012:TAFlDxhrll:- ENSG00000119979:FAM45Axhrl0:+: 120864275: 12086453 : 176959443 : 176959642: 176952206: 176981249 :93466515: 93466563: 93463878:93467790 4:120863709:120864822

ENSG00000090097:PCBP4:chr3:- ENSG00000169598:DFFB:chrl:+:3789577:3789701:37891 ENSGOOOOO 186625 :KATNA1 :chr6 : -

:51995956:51996104:51995320:52001341 36:3800070 : 149922729: 149922935: 149919486: 149924403

ENSG00000102312:PORCN:chrX:+:48372514:48372529:4 ENSG00000158863:FAM160B2:chr8:+:21947271:2194736 ENSG00000109339:MAPK10:chr4:-

8371240:48372627 5:21946809:21951950 :87010358:87010430:86989108:87022204

ENSG00000143434:SEMA6C:chrl:- ENSG00000156976 :EIF4A2:chr3 :+: 186506098 : 186506209 : ENSG00000154065:ANKRD29:chrl8:-

: 151110791: 151110882: 151110581: 151111105 186505671:186506913 :21192055:21192154:21181273:21197695

ENSG00000179912:R3HDM2:chrl2:- ENSG00000134313:KIDINS220:chr2:- ENSG00000178691:SUZ12:chrl7:+:30274635:30274704:30

:57686354:57686450:57677839:57689181 :8887274:8887331:8877129:8888016 267505:30293165

ENSG00000144677:CTDSPL:chr3:+:37988547:37988702:3 ENSG00000073921 :PICALM:chrl 1 :- ENSGOOOOO 134278 : SPIRE1 : chrl 8 : -

7903769:38006061 :85701292:85701442:85695016:85707868 : 12459753: 12459927: 12454482: 12463349

ENSG00000139631:CSAD:chrl2:- ENSG00000141644:MBDl:chrl8:- ENSG00000163531:NFASC:chrl:+:204919684:204919702:

: 53564960:53565225:53564286: 53565665 :47800555:47800720:47800233:47801498 204913534:204921138

ENSG00000141644:MBDl:chrl8:- ENSG00000197622:CDC42SEl:chrl:- ENSG00000125841:NRSN2:chr20:+:330281:330476:33000

:47797838:47797910:47796188:47799046 : 151029131:151029262: 151028469: 151031954 7:333853

ENSG00000145725:PPIP5K2:chr5:+: 102523014: 10252307 ENSG00000114982:KANSL3:chr2:- ENSG00000028203:VEZT:chrl2:+:95650929:95651015:956

7:102520445:102526542 : 97272706 : 97272784 : 97271248 : 97274244 50398:95656681

ENSG00000150433:TMEM218:chrll:- ENSG00000130751:NPASl:chrl9:+:47544235:47544383:4 ENSG00000126777:KTNl:chrl4:+:56139889:56139973:561

: 124972027: 124972247: 124971199: 124972532 7543808:47546067 39730:56142552

ENSG00000247774:PCED 1B-AS 1 :chrl2 : - ENSG00000110921 :MVK:chrl2:+: 110016969:110017087: 1 ENSG00000145390:USP53:chr4:+: 120189422: 120189575:1

:47604422:47604544:47603241:47609947 10013950:110017606 20188637:120190845

ENSG00000157557:ETS2:chr21:+:40178374:40178732:401 ENSG00000012660 :ELO VL5 : chr6 : - ENSG00000139624:CERS5:chrl2:-

78044:40181958 :53138017:53138142:53135525:53139887 :50526744:50526847:50524477:50528328

ENSG00000084774:CAD:chr2:+:27463434:27463485:2746 ENSGOOOOO 122085 :MTERF4 : chr2 : - ENSG00000213625:LEPROT:chrl:+:65895613:65895731:6

3229:27463778 :242038810:242039309:242029459:242041667 5891061:65897485

ENSG00000115657:ABCB6:chr2:- ENSGOOOOO 118197 :DDX59 : chrl:- ENSGOOOOO 140157 :NIP A2 : chr 15 : - :220082391:220082529:220081187:220082846 :200619552:200619804:200618354:200628154 :23027800:23027922:23021429:23034146 ENSG00000176473 :WDR25 :chrl4:+: 100847246: 10084808 ENSGOOOOO 160781 :P AQR6 xhrl:- ENSG00000079974 :RABL2B :chr22 :- 3:100842832:100934357 : 156214932: 156215029: 156214702: 156215325 :51207882:51207980:51207552:51214199

ENSG00000129351:ILF3:chrl9:+: 10795091: 10795152: 107 ENSG00000177990:DPY19L2:chrl2:- ENSGOOOOOH4956:DGUOK:chr2:+:74177753:74177859:74 94646:10798021 :63974441:63974616:63964637:63976185 154179:74185272

ENSG00000143537:ADAM15:chrl:+: 155033589: 15503366 ENSG00000090905:TNRC6A:chrl6:+:24816025:24816172: ENSG00000025772 :T0MM34 : chr20 : -

9:155033308:155033890 24815640:24816334 :43577370:43577518:43572220:43580473

ENSG00000196781:TLEl:chr9:- ENSG00000076351 : SLC46 A1 :chrl7 : - ENSG00000076864 :RAP 1 GAP :chrl : -

:84267128:84267203:84249216:84300590 :26729255:26729339:26727783 :26731633 :21930150:21930405:21929406:21932558

ENSG00000142303:ADAMTS10:chrl9:- ENSG00000242073:AC006014.7:chr7:- ENSG00000106603 :C0A1 :chr7:-

:8670507:8670694:8670243:8673015 :75113474:75113533:75104454:75115140 :43705256:43705321 :43688251 :43769027

ENSG00000002016:RAD52:chrl2:- ENSG00000164306:PRIMPOL:chr4:+: 185582927: 1855830 ENSG00000015153:YAF2:chrl2:-

: 1035961: 1036112: 1034691: 1036310 57:185580591:185587070 :42604156:42604256:42555567:42604349

ENSG00000166169:POLL:chrl0:- ENSG00000197568:HHLA3:chrl:+:70832615:70832667:70 ENSG00000069849:ATPlB3:chr3:+: 141620977: 141621069:

: 103345618: 103345913: 103344676: 103347002 832220:70833299 141596404:141622461

ENSG00000026950:BTN3Al:chr6:+:26410121:26410142:2 ENSG00000151923 :TIAL FchrlO:- ENSG00000166348:USP54:chrl0:-

6409961:26410233 : 121339982: 121340050: 121339522: 121341433 :75294357:75294528:75290593:75296026

ENSG00000115504 :EHBPl:chr2:+:63215065:63215173:63 ENSG00000073712 :FERMT2 : chrl 4 : - ENSG00000137411:VARS2:chr6:+:30887871:30887993:30 206470:63217850 :53327731:53327752:53327183:53331118 887625:30888109

ENSG00000113734:BNIPl:chr5:+: 172578568: 172578697:1 ENSG00000110931 :CAMKK2:chrl2:- ENSG00000089177 :KIF16B :chr20 :-

72573961:172581324 : 121682375: 121682418: 121678672: 121682942 : 16362742: 16362775: 16362392: 16385457

ENSGOOOOO 127483 :HP1BP3 :chrl :- ENSG00000138111:MFSD13A:chrl0:+: 104225738: 104225 ENSG00000105865 :DUS4L:chr7 :+: 107205032: 107205121:1

:21106837:21107033 :21106404:21113687 844:104221207:104228711 07204654:107207494

ENSG00000233184:RP11-

421L21.3 :chrl:+: 101549016: 101549130: 101541272: 101552 ENSG00000146147:MLIP:chr6:+:54095511:54095715:5406 ENSG00000171703:TCEA2:chr20:+:62695244:62695302:62 407 7031:54122105 694737:62697828

ENSG00000107263:RAPGEFl:chr9:- ENSG00000187239:FNBPl:chr9:- ENSG00000177697:CD151:chrll:+:834529:834745:833026 : 134479347: 134479440: 134477536: 134497182 : 132686122: 132686218: 132678259: 132687238 :836062 ENSG00000179104:TMTC2:chrl2:+:83250788:83251359:8 ENSG00000126804:ZBTBl:chrl4:+:64983317:64983469:6 ENSG00000077458:FAM76B :chrl 1 :- 3081448:83289596 4971664:64988204 :95512241:95512299:95512121:95512770

ENSG00000101901:ALG13:chrX:+: 110960180: 110960232: ENSG00000169062:UPF3A:chrl3:+: 115067205: 115067342 ENSGOOOOO 115084: SLC35F5 :chr2 :-

110956525:110961073 : 115057267: 115070263 : 114475329: 114475425 : 114472772: 114476730

ENSG00000106077:ABHDll:chr7:- ENSG00000093167 :LRRFIP2 :chr3 : - ENSG00000130958:SLC35D2:chr9:-

:73152205:73152472:73152065:73152657 :37132957:37133029:37125297:37136282 :99098998:99099066:99086451:99122435

ENSG00000015475:BID:chr22:- ENSG00000175575:PAAFl:chrll:+:73598075:73598144:7 ENSG00000079819:EPB41L2:chr6:-

:18226568:18226779:18222254:18257146 3589864:73598398 : 131191467: 131191521: 131191266: 131199243

ENSG00000061656:SPAG4:chr20:+:34206844:34206920:3 ENSG00000137177:KIF13A:chr6:- ENSG00000167182:SP2:chrl7:+:45975180:45975293:45973

4206642:34207116 : 17790102: 17790141: 17788106: 17794479 659:45992677

ENSG00000138674:SEC31A:chr4:- ENSG00000160410:SHKBPl:chrl9:+:41089506:41089623: ENSG00000197622:CDC42SEl:chrl:-

: 83782783:83782861:83778917: 83783686 41086842:41092679 : 151029131:151029262: 151027602: 151031954

ENSG00000076685:NT5C2:chrl0:- ENSG00000168256:NKIRAS2:chrl7:+:40174582:40174658 ENSG00000091009:RBM27:chr5:+:145631273:145631438:

: 104871501: 104871562: 104866463: 104899162 :40174490:40175671 145616995:145634505

ENSG00000172889:EGFL7:chr9:+: 139564057: 139564173: ENSG00000204387 : C6orf48 :chr6:+:31804075 : 31804294 :31 ENSG00000160055:TMEM234:chrl:-

139563125:139564365 803228:31805012 :32681984:32682118:32681396:32682489

ENSG00000150433:TMEM218:chrll:- ENSGOOOOOO 16864 : GLT8D 1 :chr3 :- ENSG00000137312:FLOTl:chr6:-

: 124972027: 124972247: 124971199: 124972629 :52738739: 52738968: 52734512:52739462 :30709438:30709481:30709110:30709568

ENSG00000073921 :PICALM:chrl 1 : - ENSG00000112234:FBXL4:chr6:- ENSG00000170791:CHCHD7:chr8:+:57125320:57125448:5

:85701292:85701442:85693046:85707868 :99365249: 99365595: 99353546:99374352 7124396:57127156

ENSG00000245958:RP11-

33Bl.l:chr4:+: 120418965: 120419058: 120415678: 12043350 ENSG00000147044:CASK:chrX:- ENSG00000124831:LRRFIPl:chr2:+:238647874:238647952 5 :41416284:41416353:41414888:41419031 :238629465:238657006

ENSG00000163138:PACRGL:chr4:+:20709425:20709493: ENSG00000135596:MICALl:chr6:- ENSGOOOOO 168890 :TMEM150 A:chr2 : -

20706437:20728907 : 109772802: 109772903 : 109767975 : 109773448 :85828428:85828605:85828230:85829006

ENSG00000069849:ATPlB3:chr3:+: 141620977: 141621069 ENSG00000103671:TRIP4:chrl5:+:64706283:64706410:64 ENSG00000183889:AC138969.4:chrl6:+: 16429717: 164299 : 141595752: 141622461 702027:64710739 94:16427741:16434162

ENSG00000186470:BTN3A2:chr6:+:26373124:26373325:2 ENSG00000114859:CLCN2:chr3:- ENSG00000167842 :MIS12:chrl7:+:5391515:5391909:5390 6370831:26373503 : 184071329: 184071583: 184071210: 184071888 004:5392142

ENSG00000197343:ZNF655:chr7:+:99160810:99160889:9 ENSG00000177943:MAMDC4:chr9:+: 139752637: 1397527 ENSG00000166734:CASC4:chrl5:+:44695084:44695252:44

9160117:99161485 28:139752549:139752851 673174:44705533

ENSGOOOOO 108651 :UTP6 :chrl7: - ENSG00000128563 :PRKRIP1 :chr7:+: 102006420: 10200652 ENSGOOOOO 113971 :NPHP3 :chr3 : -

:30193673:30193734:30192457:30195064 3:102004858:102016269 : 132418196: 132418294: 132416206: 132418761

ENSG00000184967:NOC4L:chrl2:+: 132631825: 13263193 ENSG00000183889:AC138969.4:chrl6:+: 16429908: 164299 ENSG00000205581:HMGNl:chr21:-

3:132630210:132635525 94:16427741:16434162 :40717755:40717884:40717200:40719304

ENSG00000283196:RP4-614C10.2:chr2:- ENSG00000176261 :ZBTB80S:chrl :- ENSG00000188002:RPll-43F13.1:chr5:-

:91842945:91843023:91816979:91843393 :33100302:33100393:33097480:33116033 : 1632758: 1632866: 1629745: 1632959

ENSG00000132600:PRMT7:chrl6:+:68345944:68346079:6 ENSGOOOOO 141504 : SAT2 :chrl7:- ENSG00000229180 : GS 1 -124K5.12 :chr7 : -

8345002:68349799 :7530260:7530362:7530111:7530460 :66041741:66041916:66038537:66057243

ENSG00000137700:SLC37A4:chrll:- ENSG00000105552:BCAT2:chrl9:- ENSGOOOOO 139428 :MMAB :chrl 2 : - : 118897280: 118897398: 118896790: 118897646 :49310256:49310331:49303554:49314240 : 109999047: 109999134: 109998909: 109999584 ENSG00000095485:CWF19Ll:chrl0:- ENSG00000229180:GSl-124K5.12:chr7:- ENSG00000127419:TMEM175:chr4:+:941496:941680:9263 : 102016018: 102016233: 102013296: 102027327 :66053498:66053567:66038537:66057243 28:944208 ENSG00000175287:PHYHDl:chr9:+: 131702647: 13170277 ENSG00000198952:SMG5:chrl:- ENSG00000099251:HSD17B7P2:chrl0:+:38658051:386581 6:131698924:131703723 : 156236297: 156236469: 156236171: 156237260 56:38654557:38658880

ENSG00000189157:FAM47E:chr4:+:77201416:77201494:7 ENSGOOOOO 135424 : ITGA7 :chrl 2 : - ENSG00000114841 :DNAHl:chr3:+:52432047:52432178:52

7192921:77204533 :56094045:56094177:56092701:56094682 431893:52432865

ENSG00000188185:LINC00265:chr7:+:39828080:3982820 ENSG00000169727:GPSl:chrl7:+:80010250:80010335:800 ENSG00000067066:SP100:chr2:+:231314275:231314425:23

3:39822398:39828952 09840:80011149 1313865:231325976

ENSG00000168385:SEPT2:chr2:+:242256913:242257014:2 ENSG00000157800:SLC37A3:chr7:- ENSG00000006194:ZNF263:chrl6:+:3335058:3335239:333

42255955:242263630 : 140043211:140043363: 140037149: 140045668 4205:3336022

ENSGOOOOO 100266:PACSIN2 :chr22: - ENSG00000141556:TBCD:chrl7:+:80858526:80858607:80 ENSG00000089022:MAPKAPK5:chrl2:+: 112306556: 11230

:43276622:43276628:43275175:43278189 851508:80869633 6665:112305473:112308888

ENSG00000165138:ANKS6:chr9:- ENSG00000107263 :RAPGEF1 :chr9:- ENSG00000168958:MFF:chr2:+:228207460:228207535:228

: 101552385: 101552888: 101547158: 101558414 : 134480317: 134480575: 134477536: 134497182 205096:228211941

ENSG00000130177:CDC16:chrl3:+: 115002119: 115002174 ENSG00000168067 :MAP4K2:chrl 1 :- ENSG00000143815:LBR:chrl:-

: 115000607: 115002273 :64568371:64568503:64568298:64568582 :225597992:225598118:225594534:225599038

ENSGOOOOO 172785 : CBWD 1 :chr9 :- ENSG00000141446:ESC01:chrl8:- ENSG00000119979:FAM45A:chrl0:+: 120864275: 12086453

: 146101: 146158: 135030: 152033 : 19120537: 19120661: 19119970: 19140819 4:120863709:120867479

ENSG00000119729:RHOQ:chr2:+:46803225:46803390:467 ENSG00000067113 :PLPP1 :chr5:- ENSG00000115896 :PLCL1 :chr2:+: 198948481 :198950956: 1

70951:46808066 :54786787: 54786942: 54771278:54830399 98670063:198953581

ENSG00000076555:ACACB:chrl2:+: 109685410: 10968550 ENSG00000089159:PXN:chrl2:- ENSG00000149179:Cllorf49:chrll:+:47008758:47008861:

8:109684253:109687788 : 120653362: 120653464: 120653076: 120659425 46958402:47073938

ENSG00000122085:MTERF4:chr2:- ENSG00000143776:CDC42BPA:chrl:- ENSG00000135502:SLC26A10:chrl2:+:58018282:5801838

:242035807:242035853:242029459:242036657 :227198578:227198764:227192812:227203780 9:58016424:58018648

ENSG00000085733:CTTN:chrll:+:70268614:70268737:70 ENSG00000160285:LSS:chr21:- ENSG00000100523:DDHDl:chrl4:-

266616:70269045 :47616115:47616181:47615670:47625749 :53518561:53518645 :53513667 :53521155

ENSG00000124831:LRRFIPl:chr2:+:238659842:23865991 ENSG00000010244:ZNF207:chrl7:+:30688486:30688534:3 ENSG00000078328:RBFOXl:chrl6:+:7680604:7680685:76 4:238657967:238661951 0687986:30689932 57340:7703816

ENSG00000183077:AFMID:chrl7:+:76198783:76198832:7 ENSGOOOOO 189367 :KIAA0408 : chr6 : - ENSG00000138688:KIAA1109:chr4:+: 123247009: 1232470

6187141:76202991 : 127772426: 127772462: 127771497: 127774991 72:123246475:123249258

ENSG00000127952:STYXLl:chr7:- ENSG00000089159:PXN:chrl2:- ENSG00000055609:KMT2C:chr7:-

:75643059:75643205:75634722:75651168 : 120657009: 120657894: 120653076: 120659425 : 151892991: 151893096: 151891653: 151896363

ENSG00000229809:ZNF688:chrl6:- ENSG00000197586:ENTPD6:chr20:+:25201867:25201969: ENSG00000135063:FAM189A2:chr9:+:72001474:72002599 :30582330:30582444:30581757:30582754 25199250:25203473 :72000863 :72003073 ENSG00000108061:SHOC2:chrl0:+: 112723882: 11272481 ENSG00000092421 : SEMA6A:chr5 : - ENSG00000144935:TRPC1 :chr3 :+: 142496473: 142496605: 1 9:112679415:112745385 :115808580:115808631 :115803443 :115808768 42467302:142521010

ENSG00000166377:ATP9B:chrl8:+:77135393:77135426:7 ENSG00000112983 :BRD8:chr5:- ENSG00000082805:ERCl:chrl2:+: 1313666: 1313678: 12992

7134101:77137246 : 137495243: 137495288: 137492956: 137495757 18:1345934

ENSG00000196914:ARHGEF12:chrll:+: 120280102: 12028 ENSG00000198208:RPS6KLl:chrl4:- ENSG00000122367:LDB3:chrl0:+:88446825:88447029:884 0159:120278532:120291461 :75375803:75375893:75375635:75377950 41560:88451652

ENSG00000166685:COGl:chrl7:+:71203840:71203878:71 ENSG00000123562 :MORF4L2 :chrX: - ENSG00000144674:GOLGA4:chr3:+:37402733:37402796:3

203395:71204452 : 102933426: 102933528: 102931979: 102940098 7396678:37407570

ENSG00000196712:NFl:chrl7:+:29579955:29580018:2957 ENSG00000141376:BCAS3:chrl7:+:59457866:59457932:5 ENSG00000087076 :HSD 17B 14 : chrl 9 : -

6137:29585361 9445855:59469337 :49335922:49336009:49318398:49337532

ENSG00000175287:PHYHDl:chr9:+: 131702877: 13170299 ENSGOOOOO 160284 : SP ATC 1L :chr21 : - ENSG00000174353:STAG3L3:chr7:- 4:131700057:131703723 :47602537:47603688:47588572:47604269 :72470880:72471004:72470382:72473543

ENSG00000126214:KLCl:chrl4:+: 104159889: 104159971: ENSG00000127419:TMEM175:chr4:+:942298:942403:941 ENSGOOOOO 176444 : CLK2 :chrl : - 104158762:104166991 942:944208 : 155235650: 155235745: 155234565: 155237800

ENSG00000058668:ATP2B4:chrl:+:203702350:203702528 ENSG00000275832:ARHGAP23:chrl7:+:36655173:366551 ENSG00000198825:INPP5F:chrl0:+: 121551028: 121551157

:203696699:203708673 96:36654752:36656838 : 121541283: 121551380

ENSG00000060971 : ACAA1 :chr3 :- ENSG00000109920:FNBP4:chrll:- ENSG00000169592:IN080E:chrl6:+:30015888:30015978:3

:38173086:38173129:38170879:38173416 :47747288:47747388:47746330:47752925 0012851:30016541

ENSG00000079819 :EPB41L2 :chr6 :- ENSG00000031823 :RANBP3 :chrl9:- ENSG00000130731:METTL26:chrl6:-

: 131197813: 131197915: 131191266: 131199243 :5957928:5957984:5933490:5978071 :685611 :685774:685340:686093

ENSG00000169592:IN080E:chrl6:+:30015888:30015978: ENSG00000047346 :FAM214 A:chrl 5 ENSGOOOOO 110851 :PRDM4 : chrl 2 : -

30012361:30016541 :52892323: 52892432: 52885933:52893282 : 108145423: 108145986: 108140201: 108147700

ENSG00000100296 :THOC5 :chr22: - ENSG00000185246:PRPF39:chrl4:+:45565626:45565961:4 ENSGOOOOO 143393 :PI4KB :chrl :-

:29927066:29927099:29925228:29927819 5565431:45566089 : 151282686: 151282731:151280277: 151298647

ENSG00000136891:TEX10:chr9:- ENSGOOOOO 111196:MAGOHB :chrl2:- ENSG00000123106:CCDC91:chrl2:+:28408513:28408595:

: 103091421: 103091557: 103090244: 103102538 : 10761696: 10761982: 10760535: 10762429 28343574:28410134

ENSG00000118705 :RPN2:chr20:+:35866804:35866852:35 ENSG00000127616:SMARCA4:chrl9:+: 11144442: 1114454 ENSG00000197530:MIB2:chrl:+: 1560937: 1561033: 156080

862498:35869705 1:11144193:11144798 8:1562029

ENSG00000152117:AC093838.4:chr2:+: 132273174: 132273 ENSG00000083097:DOPEYl:chr6:+:83863612:83863762:8 ENSG00000137965:IFI44:chrl:+:79116225:79116337:7911 320:132266181:132273886 3863339:83863898 5590:79119927

ENSG00000112320:SOBP:chr6:+: 107908283: 107908379: 1 ENSG00000111670:GNPTAB:chrl2:- ENSG00000106070:GRB10:chr7:- 07854814:107979410 :102150197:102150344:102147317:102150989 :50799968:50800065:50771605:50823583

ENSG00000198039:ZNF273:chr7:+:64377407:64377496:6 ENSG00000132881 :RSG1 :chrl :- ENSG00000157734:SNX22:chrl5:+:64444441:64444525:64

4363797:64377958 : 16559387: 16559512: 16559141: 16560106 444049:64444836

ENSG00000123636:BAZ2B:chr2:- ENSG00000128739:SNRPN:chrl5:+:25219788:25220104:2 ENSG00000240771:ARHGEF25:chrl2:+:58007798:580079

: 160284451 : 160284553 : 160269056: 160284821 5213229:25220504 02:58007543:58008113

ENSG00000136280:CCM2:chr7:+:45077851:45078025:450 ENSG00000095637:SORBSl:chrl0:- ENSG00000154134:ROB03:chrll:+: 124747832: 124748027

39456:45103516 :97194378:97194474:97192333:97197246 : 124747648: 124748193

ENSG00000102181:CD99L2:chrX:- ENSG00000108010:GLRX3:chrl0:+: 131977605: 131977684 ENSG00000154370:TRIM11 :chrl :- : 149983334: 149983409: 149963959: 149999703 : 131973353: 131978376 :228588664:228588895:228584866:228589766

ENSG00000142856:ITGB3BP:chrl:- ENSG00000117625 :RC0R3:chrl :+:211486061 :211486303 :

:63955753:63955889:63944504:63974198 211477482:211486765

ENSG00000029363 :BCLAF1 :chr6:- ENSG00000075413:MARK3:chrl4:+: 103966492: 10396653

: 136590278: 136590441 : 136589477: 136590574 7:103946827:103969218

ENSG00000160813:PPPlR35:chr7:- ENSGOOOOO 168802 : CHTF8 :chrl6:-

: 100033253 : 100033390: 100033156: 100033470 :69154955:69155073:69152428:69155338

ENSG00000132466:ANKRD17:chr4:- ENSG00000147364:FBX025:chr8:+:417719:417746:41315

:74005247:74006000:74000979:74007457 0:418714

ENSG00000170004:CHD3:chrl7:+:7810918:7811020:7810 ENSG00000101294:HM13:chr20:+:30155880:30156027:30

806:7811211 149539:30156922

ENSG00000173681:CXorf23:chrX:- ENSG00000165650:PDZD8:chrl0:-

: 19953926: 19954016: 19948058: 19955622 : 119100490: 119100613: 119078485: 119133866

ENSG00000113851:CRBN:chr3:- ENSG00000143157:POGK:chrl :+: 166816730: 166816829: 1

:3216846:3216950:3215945:3221304 66810325:166818174

ENSG00000135164:DMTFl:chr7:+:86783705:86783844:86 ENSG00000227232:WASH7P:chrl:-

781871:86792810 : 17232: 17368: 17055: 17605

ENSG00000106133 :NSUN5P2 :chr7: - ENSG00000099957:P2RX6:chr22:+:21380299:21380365:21 :72422690:72422834:72420735:72424897 380187:21380708 ENSG00000143537:ADAM15:chrl:+: 155034051:15503412 ENSG00000132716:DCAF8:chrl:- 2:155033965:155034720 : 160231074: 160231140: 160213824: 160232238

ENSG00000111271:ACAD10:chrl2:+: 112191575: 1121917 ENSG00000165695:AK8:chr9:- 19:112187149:112193471 : 135668020: 135668162: 135602921: 135690024

ENSG00000214435:AS3MT:chrl0:+: 104629840: 10462996 ENSG00000090661:CERS4:chrl9:+:8275589:8275746:827

8:104629350:104632204 4378:8306224

ENSG00000146574:CCZlB:chr7:- ENSG00000162004:CCDC78:chrl6:-

:6852606:6852668:6851694:6854394 :775412:775580:775293:775793

ENSG00000072518:MARK2:chrll:+:63671457:63671619: ENSGOOOOO 134138 :MEIS2 :chrl 5 : -

63670630:63672257 :37388489:37388608:37387815:37390167

ENSG00000152154:TMEM178A:chr2:+:39931220:399313 ENSG00000113163 :COL4A3BP:chr5:-

34:39893514:39944149 :74695134:74695212:74685512:74696029

ENSG00000143207:RFWD2:chrl:- ENSGOOOOO 146215 : CRIP3 :chr6:-

: 176145045: 176145143: 176118210: 176153768 :43273804:43273862:43273613:43273956

ENSG00000137177:KIF13A:chr6:- ENSGOOOOO 176444 : CLK2 xhrl:-

: 17771344: 17771449: 17765177: 17772138 :155238498:155238586:155238150:155239278

ENSG00000088899:LZTS3:chr20:- ENSG00000168958:MFF:chr2:+:228211941:228212100:22

:3148383:3148607:3147827:3154100 8205096:228217229

ENSG00000141556:TBCD:chrl7:+:80867160:80867183:80 ENSGOOOOO 124074 :ENKD l:chrl6:-

863929:80869633 :67697559:67697723:67697459:67699973

ENSG00000166261:ZNF202:chrll:-: 123598183: 123598303 : 123597699: 123598840

Table 3a. IRIS prediction of AS-derived TCR and CAR-T targets for 22 GBM samples, a. Prioritized TCR targets listed by unique splice junction.

ENSG00000163531:NFASC:chrl:+:204919684:20491970 ENSG00000204536:CCHCRl:chr6:- ENSG00000170946:DNAJC24:chrl 1 :+:31436357:31436496:31

2:204913534:204921138 :31122272:31122576:31118899:31124507 392406:31447833

ENSG00000206562 :METTL6 :chr3 :- ENSG00000112357:PEX7:chr6:+: 137193335: 137193391:1 ENSG00000119844: AFTPH:chr2:+:64806619:64808407:64800

: 15457004:15457090:15456421 : 15457278 37167319:137219279 202:64812555

ENSG00000124440:HIF3A:chrl9:+:46832337:46832735: ENSG00000117305:HMGCL:chrl:- ENSG00000166833:NAV2:chrll:+:20104137:20104146:20101

46828896:46834412 :24140679:24140828:24134813:24143164 755:20104552

ENSG00000112425 :EPM2A:chr6:- ENSG00000108312:UBTF:chrl7:- ENSGOOOOO 136044 : APPL2 : chrl 2 : -

: 145956380: 145956622: 145948829: 146007257 :42289711 :42289822:42289374:42290186 : 105570653: 105570794: 105569860: 105571003

ENSG00000108591:DRG2:chrl7:+: 18001583: 18001673:1 ENSGOOOOO 141504 : S AT2 :chrl 7 : - ENSG00000147100:SLC16A2:chrX:+:73749047:73749276:737

7997287:18007114 :7530260:7530362:7530111:7530460 45728:73751167

ENSGOOOOO 136861 : CDK5RAP2 : chr9 : - ENSG00000167491:GATAD2A:chrl9:+: 19612777: 196128 ENSG00000008382:MPND:chrl9:+:4354945:4355018:435441 : 123222849: 123223025: 123220900: 123230137 52:19612225:19613139 7:4357249 ENSG00000143815:LBR:chrl:- ENSG00000010361:FUZ:chrl9:- ENSG00000076685:NT5C2:chrl0:- :225597992:225598118:225594534:225599038 :50312634:50312832:50312515:50314619 : 104860419: 104860700: 104859776: 104860801 ENSG00000198176:TFDPl:chrl3:+: 114291934: 11429221 ENSG00000243156:MICAL3:chr22:- ENSG00000196586:MY06:chr6:+:76604947:76604977:76602 1:114291015:114294434 :18310409:18310547:18305826:18314619 407:76608089

ENSG00000172366:MCRIP2:chrl6:+:696471:696608:692 ENSG00000112320:SOBP:chr6:+: 107908283: 107908379: ENSG00000038002:AGA:chr4:-

249:697416 107854814:107979410 : 178357429: 178357505 : 178355643 : 178358558

ENSG00000004864 : SLC25 A13 :chr7 :- ENSG00000074181 :N0TCH3 :chrl 9 : - ENSG00000102878:HSF4:chrl6:+:67203181:67203251:67203 :95864113:95864229:95838289:95906507 : 15295105: 15295261: 15292612: 15295716 004:67203533 ENSGOOOOO 178026 :LRRC75B : chr22 : - ENSG00000106077 : ABHDl 1 :chr7:- ENSG00000072210:ALDH3A2:chrl7:+: 19576463: 19576588:1 :24984646:24985233:24984297:24985788 :73151258:73151550:73151021:73151891 9575269:19578808 ENSG00000206503 :HLA- ENSG00000068724:TTC7A:chr2:+:47185633:47185691:4 ENSG00000106351:AGFG2:chr7:+: 100154216: 100154249: 100 A:chr6:+:29912276:29912411:29912174:29912835 7184146:47202111 153358:100159881 ENSG00000143164:DCAF6:chrl :+: 167992225: 16799228 ENSGOOOOO 197119 : SLC25 A29 : chrl 4 : - ENSGOOOOO 11673 l:PRDM2:chrl :+: 14095533 :14095668:1407 5:167974031:168012262 : 100761962: 100762330: 100759714: 100765178 5982:14099572

ENSG00000213199:ASIC3:chr7:+: 150748258: 150748406 ENSG00000115661 :STK16:chr2:+:220111834:220111968: ENSG00000151914:DST:chr6:- : 150748182: 150748896 220111598:220112136 : 56329482:56329554:56328562:56330875

ENSG00000168894:RNF181:chr2:+:85823979:85824054: ENSGOOOOO 163939 :PBRM1 :chr3 : - ENSG00000079277:MKNK1 :chrl :- 85823772:85824567 :52588739:52588895:52584833:52595782 :47051545 :47051646:47049001 :47059784 ENSG00000134278:SPIREl:chrl8:- ENSG00000105483:CARD8:chrl9:- ENSG00000187609:EXD3:chr9:- : 12459753 :12459927:12454482: 12463349 :48726975:48727125:48725112:48733694 : 140249018: 140249225: 140248829: 140250719 ENSG00000102317:RBM3 :chrX:+:48434202:48434471 :4 ENSG00000139974:SLC38A6:chrl4:+:61510167:6151022 ENSG00000117868:ESYT2:chr7:- 8433671:48434701 1:61509930:61512063 : 158545471:158545534: 158542414: 158552176

ENSG00000134775:FHOD3:chrl8:+:33952642:33952707: ENSG00000136518:ACTL6A:chr3:+: 179293190: 1792932 ENSG00000146147:MLIP:chr6:+:54095511:54095715:540670

33935608:34081894 92:179292255:179294004 31:54122105

ENSG00000102710:SUPT20H:chrl3:- ENSG00000169598:DFFB:chrl:+:3782847:3782962:3782 ENSG00000124222:STX16:chr20:+:57234678:57234690:5722

: 37622700:37622736:37622073: 37625624 564:3784537 7143:57242545

ENSG00000026950:BTN3Al:chr6:+:26410121:26410142: ENSGOOOOO 147099 :HD AC8 :chrX: - ENSG00000128591:FLNC:chr7:+: 128490029: 128490128: 1284

26409961:26410233 :71715005:71715118:71684581:71787738 89632:128490437

ENSG00000118900:UBNl:chrl6:+:4921155:4921302:492 ENSG00000170791:CHCHD7:chr8:+:57125320:57125448 ENSG00000135127:BICDLl:chrl2:+: 120510314: 120510533:1 0973:4922884 :57124396:57127156 20509605:120518690

ENSG00000096746:HNRNPH3:chrl0:+:70097614:70097 ENSG00000172889:EGFL7:chr9:+: 139564057: 139564173 ENSG00000136153:LM07:chrl3:+:76381615:76382335:76378

753:70097090:70098259 : 139563125: 139564365 677:76383289

ENSG00000114520:SNX4:chr3:- EN SG00000159147 :DONSON : chr21 : - ENSG00000122481:RWDD3:chrl:+:95709766:95710254:9569

: 125208251:125208307: 125199163: 125216184 :34955793:34955972:34954552:34956895 9871:95712311

ENSG00000072195:SPEG:chr2:+:220353219:220353387: ENSG00000243943:ZNF512:chr2:+:27806524:27806583:2 ENSG00000067113 :PLPP1 :chr5 :-

220353032:220353499 7806009:27820933 : 54786787:54786942:54763977:54830399

ENSG00000120860:WASHC3:chrl2:- ENSG00000198176:TFDPl:chrl3:+: 114292132: 11429221 ENSG00000139631:CSAD:chrl2:-

: 102455025: 102455124: 102444069: 102455689 1:114291015:114294434 : 53565056:53565225:53564286:53565665

ENSG00000170004:CHD3:chrl7:+:7810918:7811020:781 ENSG00000100813:ACINl:chrl4:- ENSGOOOOO 196476 : C20orf96 : chr20 : -

0806:7811211 :23536522:23537880:23535217:23538684 :270199:270317:264722:270899

ENSG00000132600:PRMT7:chrl6:+:68381113:68381197: ENSG00000151276 :MAGI1 :chr3 :- ENSG00000196781:TLEl:chr9:-

68380183:68386150 :65361419:65361620:65350621:65364935 :84267098:84267203:84249216:84300590

ENSG00000162591:MEGF6:chrl:- ENSG00000100722:ZC3H14:chrl4:+:89063077:89063152 ENSG00000136717:BINl:chr2:-

:3413551:3413683:3413347:3413796 :89044484:89073586 : 127815048: 127815177: 127808488: 127816586

ENSG00000168904:LRRC28:chrl5:+:99903310:9990347 ENSG00000141644:MBDl:chrl8:- ENSG00000162735:PEX19:chrl>

0:99901716:99926234 :47800555:47800720:47800233:47801498 : 160253319: 160253429: 160252899: 160254844

ENSG00000143951:WDPCP:chr2:- ENSG00000177943:MAMDC4:chr9:+: 139752637: 139752 ENSG00000189046:ALKBH2:chrl2:-

:63380629:63380709:63380080:63401804 728:139752549:139752851 : 109527813: 109528012: 109526317: 109530311

ENSG00000127419:TMEM175:chr4:+:941496:941680:92 ENSG00000135486:HNRNPAl:chrl2:+:54675578:546757 ENSG00000141258:SGSM2:chrl7:+:2270564:2270699:226863

6328:944208 25:54675286:54675873 5:2274555

ENSG00000166927:MS4A7:chrll:+:60160157:60160259: ENSG00000145390:USP53:chr4:+: 120189422: 120189575: ENSG00000172661:WASHC2C:chrl0:+:46272720:46272873:4

60157069:60161259 120188637:120190845 6268806:46274400

ENSG00000173210:ABLIM3:chr5:+: 148618810: 1486188 ENSG00000095637:SORBSl:chrl0:- ENSG00000166377:ATP9B:chrl8:+:76973961:76974038:7696

40:148617166:148619321 :97131740:97131806:97127456:97135729 7012:77013380

ENSG00000106077:ABHDll:chr7:- ENSG00000073921 :PICALM:chrl 1 :- ENSG00000185164:NOM02:chrl6:-

:73152205:73152402:73152065:73152657 :85701292:85701442:85693046:85707868 : 18539334: 18539393: 18538946: 18540822

ENSG00000103197:TSC2:chrl6:+:2127598:2127727:212 ENSG00000204842:ATXN2:chrl2:- ENSG00000197343:ZNF655:chr7:+:99160816:99160889:9915

6586:2129032 : 111891480: 111891649: 111890644: 111893832 8318:99161485

ENSG00000076351 : SLC46A1 :chrl7 :- ENSG00000126214:KLCl:chrl4:+: 104159889: 104159971 ENSG00000196312:MFSD14C:chr9:-

:26729255:26729339:26727783:26731633 : 104158762: 104166991 :99735134:99735230:99721179:99775540

ENSG00000139631:CSAD:chrl2:- ENSG00000132405:TBClD14:chr4:+:7011603:7011675:7 ENSG00000126457:PRMTl:chrl9:+:50183128:50183182:5018

: 53565109:53565225:53564286: 53565665 002978:7012379 0573:50183743

ENSG00000135063:FAM189A2:chr9:+:72001474:720025 ENSG00000005243 :COPZ2 :chrl7: - ENSG00000103202:NME4:chrl6:+:448207:448394:447313:44

99:72000863:72003073 :46105041:46105155:46103841:46106490 8989

ENSG00000143207:RFWD2:chrl:- ENSG00000143537:ADAM15:chrl:+: 155033589: 1550336 ENSG00000004455:AK2:chrl:-

: 176145045: 176145143: 176118210: 176153768 69:155033308:155033890 :33497144:33497262:33490168:33502336

ENSG00000076685:NT5C2:chrl0:- ENSG00000156170 :NDUFAF6 :chr8 :+: 96046235 : 9604635 ENSG00000130803:ZNF317:chrl9:+:9268509:9268751:92680

: 104899162: 104899236: 104866463 : 104934614 0:96044326:96047681 70:9269501

ENSG00000095637:SORBSl:chrl0:- ENSG00000176155:CCDC57:chrl7:- ENSG00000171103:TRMT61B:chr2:-

:97135729:97135813:97127456:97141441 :80136349:80136481:80130736:80141649 :29083983:29084174:29075365:29092444

ENSG00000077380:DYNClI2:chr2:+: 172569276: 172569 ENSG00000104613:INTS10:chr8:+: 19677889: 19678029:1 ENSG00000197343:ZNF655:chr7:+:99160810:99160889:9915

336:172563887:172571837 9677187:19679949 8318:99161485

ENSGOOOOO 110066 :KMT5B :chrl 1 :- ENSG00000004455:AK2:chrl:- ENSG00000133872:SARAF:chr8:- :67946936:67947004:67942650:67947598 :33497144:33497262:33487304: 33502336 :29931392:29931544:29927575:29940362 ENSG00000138162:TACC2:chrl0:+: 123988860: 1239890 ENSG00000160818:GPATCH4:chrl:- ENSG00000167081:PBX3:chr9:+: 128724380: 128724493: 1287 01:123987523:123996909 : 156567826: 156567913: 156566270: 156568018 23128:128725290

ENSG00000133226:SRRMl:chrl:+:24973569:24973699: ENSG00000073921 :PICALM:chrl 1 :- ENSG00000257529:RPL36A-

24973280:24975349 :85687665:85687725:85670103:85692171 HNRNPH2:chrX:+: 100650322: 100650445: 100646810: 1006669 23

ENSG00000111144:LTA4H:chrl2:- ENSG00000141556:TBCD:chrl7:+:80867160:80867183:8 ENSG00000126457:PRMTl:chrl9:+:50183128:50183182:5018 :96397615:96397698:96396842:96400091 0863929:80869633 0573:50185166 ENSGOOOOO 172785 : CBWD 1 :chr9 :- ENSG00000213625:LEPROT:chrl:+:65895613:65895731: ENSG00000158161:EYA3:chrl:- : 151304: 151427: 146158: 152033 65891061:65897485 :28354299:28354437:28343750:28362054

ENSG00000183474:GTF2H2C:chr5:+:68863979:6886403 ENSG00000126777:KTNl:chrl4:+:56139889:56139973:5 ENSG00000166783:KIAA0430:chrl6:-

4:68862880:68868271 6139730:56142552 : 15719228: 15719657: 15719030: 15724188

ENSG00000122490:PQLCl:chrl8:- EN SG00000204642 :HLA- ENSG00000126217:MCF2L:chrl3:+: 113745434: 113745509: 11

:77679183:77679400:77664183:77703328 F:chr6:+:29692807:29693083:29692225:29693223 3744042:113748827

ENSG00000103174:NAGPA:chrl6:- ENSG00000196712:NFl:chrl7:+:29579955:29580018:295 ENSGOOOOO 116641 :DOCK7 :chrl :-

:5078297:5078399:5078186:5078880 76137:29585361 :63010617:63010710:63009416:63018402

ENSG00000172869:DMXLl:chr5 :+: 118542528: 11854259 ENSG00000144674:GOLGA4:chr3:+:37402733:37402796 ENSG00000125246:CLYBL:chrl3:+: 100515244: 100515346: 10

1:118539131:118552595 :37396678:37407570 0511303:100517071

ENSG00000110888:CAPRIN2:chrl2:- ENSGOOOOO 163531 :NFASC:chrl :+:204931235:204931286 ENSG00000055609:KMT2C:chr7:-

:30873744:30873849:30869610:30876192 :204926954:204937376 : 151892991: 151893096: 151891653: 151896363

ENSG00000110888:CAPRIN2:chrl2:- ENSG00000125388:GRK4:chr4:+:3021367:3021558:3015 ENSG00000111670:GNPTAB:chrl2:-

:30872012:30873849:30869610:30876192 555:3024140 : 102150197: 102150344: 102147317: 102150989

ENSG00000181163:NPMl:chr5:+: 170818308: 170818428: ENSG00000163964:PIGX:chr3:+: 196455572: 196455626:1 ENSG00000183077:AFMID:chrl7:+:76201683:76201819:7620

170815010:170832305 96455007:196457862 1599:76202026

ENSG00000136699:SMPD4:chr2:- ENSG00000139116:KIF21A:chrl2:- ENSG00000140416:TPMl:chrl5:+:63356262:63356389:63354

: 130918758: 130918845: 130914969: 130921946 :39709733:39709772:39705355:39713707 844:63358094

ENSG00000158863:FAM160B2:chr8:+:21947271:219473 ENSG00000134905:CARS2:chrl3:- ENSG00000099290:WASHC2A:chrl0:+:51851921:51851993:

65:21946809:21951950 : 111350264: 111350314:111340365 : 111353784 51851278:51853027

ENSG00000184182:UBE2F:chr2:+:238903385:23890345 ENSG00000111554:MDMl:chrl2:- ENSG00000135424:ITGA7:chrl2:-

1:238881867:238933982 :68710360:68710390:68710033:68715126 :56094045:56094177:56092701:56094682

ENSG00000104852:SNRNP70:chrl9:+:49605370:496054 ENSG00000188157:AGRN:chrl:+:987372:987396:987195 ENSG00000150712:MTMR12:chr5:-

30:49604728:49607890 :988840 :32235067:32235235:32230453:32239106

ENSG00000007376:RPUSDl:chrl6:- ENSG00000090565:RABllFIP3:chrl6:+:541133:541268: ENSG00000147099:HDAC8:chrX:-

:837076:837179:836928:837353 539000:546823 :71708782:71708891:71684581:71787738

ENSG00000123349:PFDN5:chrl2:+:53690027:53690059: ENSG00000104852:SNRNP70:chrl9:+:49605370:4960544 ENSG00000081377:CDC14B:chr9:-

53689423:53691633 2:49604728:49607890 :99277930:99278074:99272071:99284787

ENSG00000170525:PFKFB3:chrl0:+:6270158:6270181:6 ENSG00000112983 :BRD8:chr5:- ENSG00000165801:ARHGEF40:chrl4:+:21555478:21555622:

268328:6274857 : 137502206: 137502416: 137501797: 137503622 21554025:21556126

ENSG00000102181:CD99L2:chrX:- ENSG00000129116:PALLD:chr4:+: 169846383: 169846429 ENSG00000228486:LINC01125 :chr2:+:98318523:98318630:9 : 149983334: 149983409: 149963959: 149999703 : 169846229: 169847363 8317767:98319131 ENSG00000085978:ATG16Ll:chr2:+:234182366:234182 ENSG00000114416:FXRl:chr3:+: 180693100: 180693192:1 ENSG00000143549:TPM3:chrl:- 423:234181698:234183321 80688146:180693909 : 154143888: 154143964: 154143187: 154145383

ENSG00000196199:MPHOSPH8:chrl3:+:20244979:2024 ENSGOOOOO 139620 :KANSL2:chrl 2 : - ENSG00000164896:FASTK:chr7:-

5104:20244503:20245345 :49056342:49056437:49054402:49061475 : 150773999: 150774114: 150773919: 150774396

ENSG00000134313 :KIDINS220 : chr2 : - ENSG00000065882:TBClDl:chr4:+:38054726:38054846: ENSGOOOOO 115310 :RTN4 : chr2 : -

:8887274:8887331:8877129:8888016 38053681:38055819 : 55255299:55255356:55214834:55276880

ENSG00000165219:GAPVDl:chr9:+: 128104497: 1281045 ENSG00000138709:LARPlB:chr4:+: 129131010: 12913114 ENSG00000011143 :MKSl:chrl7:-

78:128103543:128109097 8:129128538:129141509 : 56283825:56283908:56283741:56284445

ENSG00000143434:SEMA6C:chrl:- ENSG00000135164:DMTFl:chr7:+:86823999:86824144:8 ENSG00000076685:NT5C2:chrl0:-

: 151110791: 151110882: 151110581: 151111105 6823418:86824346 : 104871501: 104871562: 104866463: 104899162

ENSG00000127419:TMEM175:chr4:+:942298:942403:94 ENSG00000165914:TTC7B:chrl4:- ENSG00000171307:ZDHHC16:chrl0:+:99213555:99213603:9

1942:944208 :91069596:91069647:91059970:91077085 9213420:99214470

ENSG00000152749:GPR180:chrl3:+:95271403:95271584 ENSG00000145362:ANK2:chr4:+: 114293688: 114293781: ENSG00000173947:PIFO:chrl:+: 111891137: 111891268: 11188

:95264644:95271721 114290961:114294245 9671:111892727

ENSG00000067113 :PLPP1 :chr5 : - ENSG00000148019:CEP78:chr9:+:80880774:80880822:80 ENSG00000099219:ERMPl:chr9:-

: 54786787:54786942:54771278: 54830399 880459:80881357 :5805610:5805785:5801328:5810010

ENSGOOOOO 197119 : SLC25 A29 :chrl4 :- ENSG00000134905:CARS2:chrl3:- ENSG00000122786:CALDl:chr7:+: 134620438: 134620516: 134

: 100761962: 100762034: 100759714: 100765178 : 111302983 : 111303447: 111299586: 111315797 618141:134625842

ENSG00000135486:HNRNPAl:chrl2:+:54676862:54677 ENSG00000101294:HM13:chr20:+:30155880:30156027:3 ENSG00000114956:DGUOK:chr2:+:74166036:74166149:7415

018:54676658:54677595 0154098:30156922 4179:74184251

ENSG00000134909:ARHGAP32:chrll:- ENSG00000103034:NDRG4:chrl6:+:58533047:58534981: ENSG00000088298:EDEM2:chr20:-

: 128910822: 128910904: 128868363 : 128932174 58528912:58537701 : 33722540:33722752:33714178:33725682

ENSG00000206503 :HLA- ENSG00000185630:PBX1 :chrl :+: 164789308:164789421: 1 ENSG00000130066:SATl:chrX:+:23802410:23802520:238018

A:chr6:+:29912276:29912393:29912174:29912835 64781386:164790773 26:23803444

ENSG00000175066:GK5:chr3:- ENSG00000071054:MAP4K4:chr2:+: 102487955: 1024881 ENSG00000154065:ANKRD29:chrl8:-

: 141903552: 141904635: 141901891:141904770 47:102486877:102490108 :21192055:21192154:21181273:21197695

ENSG00000171103:TRMT61B:chr2:- ENSGOOOOO 112701: SENP6 :chr6 :+:76350402 :76350420 :76 ENSG00000124275:MTRR:chr5:+:7873485:7873639:7871036:

:29087882:29087985 :29075365 :29092444 344527:76357446 7875370

ENSGOOOOO 184381 :PL A2G6 : chr22 : - ENSGOOOOO 196821 :C6orf 106 :chr6 :- ENSG00000165695:AK8:chr9:-

: 38524275:38524437:38522456: 38525460 :34614377:34614575:34574681:34622401 : 135668020: 135668162: 135602921: 135690024

ENSG00000137312:FLOTl:chr6:- ENSG00000031003 :FAM13B :chr5 :- ENSG00000121753:ADGRB2:chrl:-

:30709568:30709644:30709110:30709923 : 137292165: 137292231:137290065: 137295304 :32205710:32205779:32205635:32205947

ENSG00000102317:RBM3 :chrX:+:48434309:48434471 :4 ENSGOOOOO 126746 :ZNF384 : chrl 2 : - ENSG00000132881:RSGl:chrl:-

8434055:48434701 :6781515:6781698:6780004:6782381 : 16559387: 16559512: 16559141: 16560106

ENSG00000145214:DGKQ:chr4:- ENSG00000143549:TPM3:chrl:- ENSG00000138279:ANXA7:chrl0:-

:957860:957881:957078:958963 : 154141780: 154141859: 154130197: 154142875 :75155801:75155867:75148172:75156276

ENSG00000090857:PDPR:chrl6:+:70164325:70164447:7 ENSG00000089022:MAPKAPK5:chrl2:+: 112306556: 112 ENSG00000073921 :PICALM:chrl 1 : -

0163025:70166053 306665:112305473:112308888 :85689112:85689136:85687725:85692171

ENSGOOOOO 186866 :P0FUT2 : chr21 : - ENSG00000144283:PKP4:chr2:+: 159533250: 159533379:1 ENSG00000129675:ARHGEF6:chrX:-

:46685936:46686142:46685550:46687504 59530512:159536940 : 135761693: 135761819: 135758876: 135762889

ENSG00000189339:SLC35E2B:chrl:- ENSG00000186470:BTN3A2:chr6:+:26373124:26373325: ENSGOOOOO 115084: SLC35F5 :chr2 :-

: 1602947: 1603068: 1599911:1606901 26370831:26373503 : 114475329: 114475425 : 114472772: 114476730

ENSG00000250644:RPll-295K3:chrll:- ENSGOOOOO 196504 :PRPF40 A:chr2: - ENSG00000047849:MAP4:chr3:-

: 1768896: 1769349: 1756659: 1775032 : 153535569: 153535623: 153533989: 153535865 :47910703:47910817:47899002:47912302

ENSG00000112031:MTRFlL:chr6:- ENSGOOOOO 180398 :MCFD2 :chr2 : - ENSG00000108064:TFAM:chrl0:+:60150524:60150620:60148

: 153312319: 153312456: 153311230: 153313991 :47136161:47136316:47135108:47142861 579:60154117

ENSG00000165868:HSPA12A:chrl0:- ENSGOOOOO 172663 :TMEM134:chrl 1 :- ENSG00000157869:RAB28:chr4:-

: 118441301: 118441388: 118440767: 118443301 :67232526:67232571:67232327:67234782 : 13462322: 13462452: 13383218: 13475941

ENSG00000173744:AGFGl:chr2:+:228414774:22841482 ENSG00000114982:KANSL3:chr2:- ENSG00000143702:CEP170:chrl:-

2:228401709:228416674 :97272706:97272784:97271248:97274244 :243349080:243349374:243336148:243349560

ENSG00000151612:ZNF827:chr4:- ENSG00000033100:CHPF2:chr7:+: 150933493: 150933676 ENSG00000029363 :BCLAF1 :chr6:-

: 146791396: 146791630: 146770713: 146806829 : 150932698: 150934459 : 136597605: 136597646: 136597127: 136599002

ENSG00000089177:KIF16B:chr20:- ENSG00000136280:CCM2:chr7:+:45077851:45078025:45 ENSG00000159788:RGS12:chr4:+:3430284:3430438:3429896:

: 16354901: 16355054: 16352406: 16359449 039962:45103516 3432133

ENSG00000103148:NPRL3:chrl6:- ENSG00000186635:ARAP1 :chrl 1 :- ENSG00000175287:PHYHDl:chr9:+: 131700035: 131700057:1

: 174935: 175072: 169254: 180520 :72403797:72403830:72399582:72404369 31698924:131703723

ENSG00000100241 : SBF 1 : chr22 : - ENSG00000095637:SORBSl:chrl0:- ENSG00000058453:CROCC:chrl:+: 17297959: 17298142: 1729

:50895462:50895540:50895102:50897683 :97154757:97154832:97144042:97156976 7262:17298854

ENSG00000132600:PRMT7:chrl6:+:68382244:68382334: ENSGOOOOO 138688 :KIAA1109 :chr4:+: 123247009: 123247 ENSG00000140299:BNIP2:chrl5:-

68380183:68386150 072:123246475:123249258 :59970946:59971033:59970286:59971790

ENSG00000162004:CCDC78:chrl6:- ENSGOOOOO 189292 : ALKAL2 :chr2 :- ENSG00000079974:RABL2B:chr22:-

:775412:775580:775293:775793 :286122:286203:283175:286289 :51207882:51207977:51207552:51214199

ENSG00000165495:PKNOX2:chrll:+: 125279934: 125281 ENSGOOOOO 112425 :EPM2 A: chr6 : - ENSG00000117262:GPR89A:chrl:- 761:125267958:125298907 : 146042036: 146042291:146007432: 146056333 : 145822813: 145822859: 145818826: 145826887

ENSG00000213995:NAXD:chrl3 :+: 111274562: 11127471 ENSG00000073921 :PICALM:chrl 1 :- ENSGOOOOO 118194 :TNNT2 :chrl :-

3:111267994:111286891 :85671717:85671820:85670103:85692171 :201338943:201338973:201337355:201341154

ENSG00000196118:CCDC189:chrl6:- ENSG00000153391:IN080C:chrl8:- ENSG00000166685:COGl:chrl7:+:71203840:71203878:71203

:30770498:30770568:30768975:30771604 :33058245:33058313:33048706:33077682 395:71204452

ENSG00000151923:TIALl:chrl0:- ENSG00000124440:HIF3A:chrl9:+:46815762:46815910:4 ENSG00000115414:FNl:chr2:-

: 121339982: 121340358: 121339522: 121341433 6815524:46823699 :216236831:216237098:216236738:216238044

ENSG00000133884:DPF2:chrll:+:65112050:65112092:6 ENSG00000175662:TOMlL2:chrl7:- ENSGOOOOO 113971 :NPHP3 :chr3 : -

5111540:65113136 : 17761082: 17761169: 17754266: 17764789 : 132418196: 132418294: 132416206: 132418761

ENSG00000104218:CSPPl:chr8:+:68062017:68062170:6 ENSG00000101901:ALG13:chrX:+: 110960180: 11096023 ENSG00000173264:GPR137:chrll:+:64055536:64055686:640

8049838:68066258 2:110956525:110961073 55418:64055811

ENSG00000168256:NKIRAS2:chrl7:+:40174587:401746 ENSG00000115977:AAKl:chr2:- ENSG00000105662:CRTCl:chrl9:+: 18885709: 18885796: 1888

58:40174490:40175671 :69723116:69723212:69709944:69732700 2356:18886450

ENSGOOOOO 139746 :RBM26 :chrl 3 : - ENSG00000154743:TSEN2:chr3:+: 12560557: 12560696:1 ENSGOOOOO 166169 :POLL :chrlO : -

:79927287 :79927359:79918929:79928573 2546730:12570386 : 103342519: 103342648: 103340173: 103347002

ENSG00000176155:CCDC57:chrl7:- ENSG00000130751:NPASl:chrl9:+:47544282:47544383: ENSG00000089159:PXN:chrl2:-

:80136902:80137065:80136481:80141649 47543808:47546067 : 120653362: 120653464: 120653076: 120659425

ENSGOOOOO 196923 :PDLIM7 :chr5 : - ENSG00000186868:MAPT:chrl7:+:44087675:44087768:4 ENSG00000163719:MTMR14:chr3:+:9719667:9719742:97190

: 176918807: 176918926: 176918421:176919405 4074030:44091608 71:9724861

ENSG00000145730:PAM:chr5:+: 102363888: 102363942:1 ENSG00000101190:TCFL5:chr20:- ENSG00000110888:CAPRIN2:chrl2:-

02361038:102364590 :61490715:61490878:61473449:61491476 :30872012:30872159:30869610:30876192

ENSG00000107077:KDM4C:chr9:+:6981841:6982765:69 ENSG00000095637:SORBSl:chrl0:- ENSG00000073712:FERMT2:chrl4:-

81118:6984165 :97131082:97131184:97127456:97135729 :53348513:53348546:53348187:53360010

ENSG00000095637:SORBSl:chrl0:- EN SG00000240771 : ARHGEF25 :chrl2 :+: 58007798 : 58007 ENSGOOOOO 178053 :MLF1 :chr3 :+: 158306640: 158306713: 1582

: 97110965:97111133:97106209: 97114638 902:58007543:58008113 89136:158310222

ENSG00000133030:MPRIP:chrl7:+: 17083920: 17083983: ENSG00000169756:LIMSl:chr2:+: 109297424: 109297568: ENSG00000050130:lKAMP:chrl4:+:59953430:59953522:5995

17083402:17088136 109297226:109300340 1311:59954391

ENSG00000143797 :MBOAT2:chr2 : - ENSG00000077458:FAM76B :chrl 1 :- ENSG00000110921:MVK:chrl2:+: 110016969: 110017087: 110

: 9002400 :9002452: 9000894 :9002719 :95512241:95512299:95512121:95512770 013950:110017606

ENSG00000106077:ABHDll:chr7> ENSG00000083535:PIBFl:chrl3:+:73539411:73539542:7 ENSG00000163528:CHCHD4:chr3:-

:73152205:73152472:73152065:73152657 3505405:73572959 : 14163416: 14163586: 14158024: 14166154

ENSGOOOOO 100266:PACSIN2 :chr22: - ENSGOOOOO 138777 :PP A2 :chr4 : - ENSG00000196557:CACNAlH:chrl6:+: 1262510: 1262528: 126

:43276622:43276628:43275175:43278189 : 106359106: 106359193: 106345479: 106367539 2138:1263779

ENSG00000073536:NLEl:chrl7:- ENSG00000087076:HSD17B14:chrl9:- ENSG00000198399:ITSN2:chr2:-

: 33466838:33467085:33466333: 33468997 :49334924:49335016:49318398:49337532 :24507631:24507712:24498718:24509080

ENSG00000106077:ABHDll:chr7:- ENSGOOOOO 157800: SLC37A3 :chr7 : - ENSG00000136754:ABIl:chrl0:-

:73151258:73151440:73151021:73151891 : 140043211:140043363: 140037149: 140045668 :27052808:27052889:27048167:27054146

ENSG00000135250:SRPK2:chr7:- ENSGOOOOO 152952 :PL0D2 :chr3 :- ENSG00000120549:KIAA1217:chrl0:+:24783428:24783533:2

: 104766694: 104766787: 104766321 : 104767439 : 145795648: 145795711:145794682: 145796902 4762989:24784075

ENSG00000160323:ADAMTS13:chr9:+: 136323031:1363 ENSG00000114125:RNF7:chr3:+: 141461485: 141461749:1 ENSG00000103174:NAGPA:chrl6:-

23216:136321841:136324095 41457351:141462350 :5078297:5078366:5078186:5078880

ENSG00000117859:OSBPL9:chrl:+:52135105:52135184: ENSG00000090905:TNRC6A:chrl6:+:24816025:2481617 ENSG00000180900:SCRIB:chr8:- 52117713:52179674 2:24815640:24816334 : 144873835: 144873910: 144873610: 144874045

ENSGOOOOO 166387 :PPFIBP2 :chrl 1 :+:7662263 :7662296 :7 ENSG00000054277:OPN3 :chrl :- ENSG00000152154:TMEM178A:chr2:+:39934188:39934326:3 661101:7662709 :241767561:241767881:241761299:241803183 9931334:39944149

ENSG00000115896 :PLCLl:chr2:+: 198948481: 198950956 ENSG00000163719:MTMR14:chr3:+:9739394:9739550:9 ENSGOOOOO 128159 : TUB GCP6 : chr22 : - : 198670063: 198953581 731827:9743473 :50659703:50660303:50658444:50660456

ENSG00000149100:EIF3M:chrll:+:32608557:32608690: ENSG00000198039:ZNF273:chr7:+:64377407:64377496:6 ENSG00000083097:DOPEYl:chr6:+:83863612:83863762:838

32605475:32611092 4363797:64377958 63339:83863898

ENSG00000274769:RP11- ENSGOOOOO 139620 :KANSL2:chrl 2 : - ENSG00000169727:GPSl:chrl7:+:80010134:80010335:80009

493E12:chr2:+:61344491:61344520:61343205:61344601 :49072818:49073021:49065745:49073437 840:80011149 ENSG00000131778:CHDlL:chrl:+: 146751698: 14675186 ENSGOOOOO 169231 :THBS3 :chrl :- ENSG00000067225 :PKM:chrl 5 :- 4:146747921:146757000 : 155165777: 155165917: 155165690: 155166831 :72495362:72495529:72492996:72499068 ENSG00000072110:ACTNl:chrl4:- ENSGOOOOO 169045 :HNRNPH1 :chr5 : - ENSG00000102317:RBM3:chrX:+:48434202:48434471:48434 :69345174:69345240:69343957:69346678 : 179045145: 179045324: 179044912: 179047892 055:48434701 ENSG00000169220:RGS14:chr5:+: 176798475: 176798590 ENSG00000140416:TPMl:chrl5:+:63353396:63353472:6 ENSG00000101198:NKAIN4:chr20:- : 176798397: 176798873 3353138:63353911 :61873890:61873975:61872858:61875375

ENSG00000105357:MYH14:chrl9:+:50727410:50727434 ENSG00000148481:MINDY3:chrl0:- ENSG00000165055:METTL2B:chr7:+: 128118002: 128118046:

:50726606:50728841 : 15858833: 15858914: 15838171: 15863654 128117227:128119211

ENSG00000204463:BAG6:chr6:- ENSG00000198722:UNC13B:chr9:+:35364541:35364564: ENSG00000142856:ITGB3BP:chrl:-

:31607276:31607423 :31607003 :31607975 35313986:35366943 :63955753:63955889:63944504:63974198

ENSG00000130177:CDC16:chrl3:+: 115002119: 1150021 ENSG00000169062:UPF3A:chrl3:+: 115051733: 11505187 ENSG00000148481:MINDY3:chrl0:-

74:115000607:115002273 5:115047602:115051993 :15880226:15880278:15879317:15883424

ENSG00000047849:MAP4:chr3:- ENSG00000143612:Clorf43:chrl:- ENSG00000125457:MIF4GD:chrl7:-

:47910703:47910817:47908828:47912302 : 154192311 : 154192413 : 154187050: 154192817 :73263826:73263982:73263711:73264163

ENSG00000104067:TJPl:chrl5:- ENSG00000166169:POLL:chrl0:- ENSG00000130731:METTL26:chrl6:-

:30011980:30012220:30011342:30012561 : 103343264: 103343438: 103342648: 103347002 :684888:684956:684797:686093

ENSG00000163629:PTPN13:chr4:+:87674161:87674218: ENSG00000137965:IFI44:chrl:+:79126238:79126339:791 ENSG00000072736:NFATC3:chrl6:+:68248231:68248335:682

87672277:87679412 25168:79128388 25678:68260252

ENSG00000111364:DDX55:chrl2:+: 124103215: 1241033 ENSG00000159761:C16orf86:chrl6:+:67701129:6770142 ENSG00000151092:NGLYl:chr3:- 84:124101150:124103994 8:67700975:67701780 :25761504:25761682:25761126:25770623

ENSG00000118705 :RPN2:chr20:+:35866804:35866852:3 ENSGOOOOO 154370 :TRIMll:chrl:- ENSG00000164896:FASTK:chr7:- 5865112:35869705 :228588664:228588895:228584866:228589766 : 150773999: 150774323: 150773919: 150774396 ENSG00000103148:NPRL3:chrl6:- ENSG00000152061:RABGAPlL:chrl:+: 174957777: 17495 ENSG00000143776:CDC42BPA:chrl:- : 180520: 180590: 162774: 188148 7975:174952042:174958985 :227198578:227198764:227192812:227203780 ENSG00000258461:RP11- ENSG00000169398:PTK2:chr8:- ENSG00000258555:SPECC1L-

164J13:chrl5:+:42700408:42700522:42695975:42701500 : 141772466: 141772487: 141771361:141774332 ADORA2A:chr22:+:24829098:24829704:24765288:24836550 ENSGOOOOO 138606: SHF :chrl 5 : - ENSG00000129353:SLC44A2:chrl9:+: 10753572: 1075369 ENSG00000115414:FNl:chr2:- :45464346:45464516:45464200:45467416 7:10753127:10753954 :216236831:216237023:216236738:216238044 ENSG00000173210:ABLIM3:chr5:+: 148617010: 1486171 ENSG00000136811:ODF2:chr9:+:131231461:131231632: ENSG00000121897:LIAS:chr4:+:39466904:39466962:3946522 66:148612863:148619321 131223346:131233586 5:39469137

ENSG00000095794:CREM:chrl0:+:35490378:35490414: ENSG00000154556:SORBS2:chr4:- ENSG00000066855:MTFRl:chr8:+:66601800:66601834:66594

35484142:35495822 : 186598150: 186598792: 186583396: 186599576 686:66605878

ENSG00000131389:SLC6A6:chr3:+: 14509595: 14509720: ENSG00000136717:BINl:chr2:- ENSG00000133816:MICAL2:chrll:+: 12262586: 12262709: 122

14509464:14513712 : 127809830: 127809938: 127806209: 127816586 61132:12270730

ENSG00000121753:ADGRB2:chrl:- ENSG00000257103:LSM14A:chrl9:+:34706028:3470620 ENSG00000169738:DCXR:chrl7:-

:32193625:32193682:32193206:32193782 5:34699956:34706500 :79994289:79994324:79994184:79994419

ENSG00000088367:EPB41Ll:chr20:+:34797409:3479782 ENSG00000085733:CTTN:chrll:+:70268614:70268737:7 ENSG00000075413:MARK3:chrl4:+: 103966492: 103966537:1

0:34785963:34800193 0266616:70269045 03964865:103969218

ENSG00000169592:IN080E:chrl6:+:30015888:30015978 ENSGOOOOO 168067 :MAP4K2 :chrl 1 :- ENSG00000114859:CLCN2:chr3:-

:30012361:30016541 :64568371:64568503 :64568298:64568582 : 184071329: 184071583: 184071210: 184071888

ENSGOOOOO 162585 :FAAP20 :chrl :- ENSG00000139546:TARBP2:chrl2:+:53898918:53899046 ENSG00000028203:VEZT:chrl2:+:95650929:95651015:95650

:2121151:2121220:2116952:2125077 :53898599:53899432 398:95656681

ENSG00000122786:CALDl:chr7:+: 134620438: 13462051 ENSG00000172366:MCRIP2:chrl6:+:696471:696608:692 ENSG00000131375:CAPN7:chr3:+: 15282959: 15283095: 15282

6:134618828:134625842 043:697416 360:15283684

ENSG00000152952:PLOD2:chr3:- ENSG00000164818:DNAAF5:chr7:+:819589:819781:8147 ENSG00000145725:PPIP5K2:chr5:+: 102518934: 102519108: 10

: 145795648: 145795711: 145791139: 145796902 99:825153 2515889:102520372

ENSG00000168958:MFF:chr2:+:228207460:228207535:2 ENSG00000132530:XAFl:chrl7:+:6662574:6662838:666 ENSG00000028203:VEZT:chrl2:+:95650325:95650398:95645

28205096:228217229 1543:6662980 847:95650925

ENSG00000036448:MYOM2:chr8:+:2090299:2090322:20 ENSG00000143742:SRP9:chrl:+:225976735:225976843:2 ENSG00000095637:SORBSl:chrl0:-

89100:2091324 25971070:225976941 :97131082:97131184:97127456:97141441

ENSG00000109536:FRGl:chr4:+: 190876191: 190876306: ENSG00000124074:ENKDl:chrl6:- ENSG00000163719:MTMR14:chr3:+:9739394:9739550:97307 190873442:190878552 :67697559:67697723:67697459:67699973 66:9743473

ENSG00000108010:GLRX3:chrl0:+: 131977605: 1319776 ENSGOOOOO 127481 :UBR4 :chrl : - ENSG00000049323:LTBPl:chr2:+:33567904:33568030:33540 84:131973353:131978376 : 19476256 : 19476289 : 19475120 : 19477070 336:33572433

ENSG00000124523:SIRT5:chr6:+: 13599263: 13599387: 13 ENSGOOOOO 116001 :TIA1 :chr2: - ENSG00000137965:IFI44:chrl:+:79126238:79126376:7912516 597248:13601065 :70456190:70456223:70454954:70456395 8:79129449

ENSGOOOOO 143393 :PI4KB xhrl : - ENSG00000157045:NTANlxhrl6:- ENSG00000172292:CERS6xhr2:+: 169622831 : 169622855 : 169

: 151282686: 151282731:151280277: 151288048 : 15141711:15141777: 15141407: 15149747 622258:169626019

ENSG00000197586:ENTPD6:chr20:+:25201867:2520196 ENSGOOOOO 168890 :TMEM150 A:chr2 : - ENSG00000133872:SARAFxhr8:-

9:25199250:25203473 :85828428:85828605:85828230:85829006 :29931392:29931571 :29927575:29940362

ENSGOOOOO 185189 :NRBP2 xhr8 :- ENSG00000141376:BCAS3:chrl7:+:59104226:59104271: ENSG00000184967:NOC4L:chrl2:+: 132631825: 132631933: 13

: 144917989: 144918045: 144917900: 144918136 59093262:59112026 2630210:132635525

ENSG00000107679:PLEKHAl:chrl0:+: 124187791: 12418 ENSG00000133392:MYHllxhrl6:- ENSG00000177192:PUSlxhrl2:+: 132423717: 132423820: 132

7832:124186547:124189139 : 15802659: 15802698: 15797980: 15808765 416857:132428083

ENSG00000101190:TCFL5xhr20:- ENSG00000131748:STARD3:chrl7:+:37814961:3781507 ENSG00000130733:YIPF2xhrl9:-

:61485367:61485509:61473449:61491476 3:37814775:37815303 : 11038305: 11038392: 11036449: 11038474

ENSG00000143537:ADAM15:chrl:+: 155034051:155034 ENSG00000077232:DNAJC10:chr2:+: 183600975: 1836011 ENSG00000154930:ACSSlxhr20:-

122:155033965:155034720 13:183597269:183605025 :25000645:25000783:24995866:25011394

ENSG00000205362:MTlA:chrl6:+:56673175:56673241:5 ENSG00000149577:SIDT2:chrll :+: 117057705:117057717 ENSG00000186501:TMEM222xhrl:+:27657475:27657628:27 6672678:56673770 : 117057352: 117058093 657295:27658560

ENSG00000006634:DBF4:chr7:+:87533606:87533731:87 ENSG00000124596:OARDlxhr6:- ENSG00000213614:HEXA:chrl5:-

530193:87536502 :41037814:41037873:41035176:41038870 :72645408:72645519:72643575:72647899

ENSG00000107036:RICl:chr9:+:5753535:5753646:57532 ENSGOOOOO 126106 :TMEM53 xhrl : - ENSG00000172766:NAA16xhrl3:+:41936866:41937009:4193

38:5754840 :45125845:45125967:45111136:45140002 6295:41941574

ENSG00000157764:BRAF:chr7:- ENSG00000166169:POLL:chrl0:- ENSG00000189157:FAM47Exhr4:+:77201416:77201494:7719

: 140434416: 140434570: 140426316: 140439611 : 103345618: 103345913: 103342648: 103347002 2921:77204533

ENSG00000095637:SORBSlxhrl0:- ENSG00000129467:ADCY4xhrl4:- ENSG00000135097:MSIlxhrl2>

:97194378:97194474:97192333:97197246 :24790921:24791182:24789094:24791271 : 120789146: 120789203 : 120785317: 120791101

ENSG00000104852:SNRNP70:chrl9:+:49605370:496068 ENSG00000118705:RPN2xhr20:+:35866804:35866852:35 ENSG00000101040:ZMYND8xhr20:-

44:49604728:49607890 862498:35869705 :45841286:45841370:45839542:45848908

ENSGOOOOO 156976 :EIF4A2:chr3:+: 186502750: 18650289 EN SGOOOOO 164347: GFM2 : chr5 : - ENSG00000148842:CNNM2xhrl0:+: 104831530: 104831596:1 0:186502485:186503671 :74034326:74034467:74034242:74035813 04828479:104835842

ENSG00000126214:KLCl:chrl4:+: 104153417: 104153548 ENSG00000084234:APLP2 xhrl 1:+: 129993506: 12999367 ENSG00000171793:CTPSlxhrl:+:41473120:41473217:41471 : 104145882: 104166991 4:129992408:129996594 766:41474330

ENSG00000179104:TMTC2:chrl2:+:83250788:83251359 ENSG00000164548:TRA2Axhr7:- ENSG00000115355:CCDC88A:chr2:-

:83081448:83289596 :23561972:23562051:23561459:23571407 :55530204:55530288:55529208:55535944

ENSG00000100523:DDHDlxhrl4:- ENSGOOOOO 136717 :BIN1 xhr2 : - ENSG00000137210:TMEM14B:chr6:+: 10755374: 10755465: 10

:53518561:53518645:53513667:53521155 : 127808729: 127808819: 127808488: 127816586 749931:10829239

ENSG00000067560:RHOAxhr3:- ENSGOOOOO 133627 : ACTR3B xhr7 :+: 152497615 : 1524977 ENSG00000078403:MLLT10xhrl0:+:21906040:21906136:219

:49398360:49398499:49397815:49412866 40:152480327:152498705 03853:21940601

ENSG00000069849:ATPlB3:chr3:+: 141620977: 1416210 ENSG00000064655 :EYA2 xhr20 :+:45702796 :45702974 :4 ENSG00000095637:SORBSlxhrl0:-

69:141595752:141622461 5644936:45717877 :97131082:97131184:97127456:97131740

ENSG00000136699:SMPD4xhr2:- ENSGOOOOO 120318 : ARAP3 xhr5 :- ENSG00000008083:JARID2xhr6:+: 15410454: 15410596: 1537

: 130918758: 130918845: 130914248: 130921946 : 141034928: 141034967: 141034002: 141035187 4483:15452236

ENSG00000117859:OSBPL9:chrl:+:52221991:52222030: ENSG00000229809:ZNF688xhrl6:- ENSG00000175575:PAAFlxhrll:+:73598084:73598144:7358

52215867:52226361 :30582330:30582444:30581757:30582754 9864:73598398

ENSG00000160410:SHKBPl:chrl9:+:41089506:4108962 ENSGOOOOO 196263 :ZNF471 xhrl 9 :+: 57027643 :57027770 : ENSG00000109920:FNBP4xhrll>

3:41086842:41092679 57022973:57029850 :47747288:47747388:47746330:47752925

ENSG00000113504:SLC12A7:chr5:- ENSG00000106077 : ABHDl 1 :chr7:- ENSGOOOOO 124787:RPP40 :chr6 :-

: 1056696: 1056711:1053597: 1057585 :73151550:73151721:73151021:73151891 :5000796:5000865:5000138:5002334

ENSG00000115977: AAKl:chr2:- ENSGOOOOO 119723 :C0Q6 :chrl4 :+:74426117 :74426225 :7 ENSG00000084693:AGBL5:chr2:+:27291915:27291962:27291

:69709842:69709944:69708093 :69723116 4425927:74427875 612:27292440

ENSG00000206562 :METTL6 :chr3 :- ENSG00000145725:PPIP5K2:chr5:+: 102523014: 10252307 ENSG00000197111:PCBP2:chrl2:+:53861588:53861627:5386

: 15457004: 15457090: 15455669: 15457278 7:102520445:102526542 1077:53862560

ENSG00000107863:ARHGAP21:chrl0:- ENSG00000197530:MIB2:chrl:+: 1560344: 1560565: 15602 ENSG00000132153:DHX30:chr3:+:47857452:47857618:47852

:24911661:24911691:24910298:24918924 81:1560665 201:47868836

ENSG00000081377:CDC14B:chr9:- ENSG00000136717:BINl:chr2:- ENSG00000145730:PAM:chr5:+: 102363885: 102363942: 10236

:99277930:99278074:99266071:99284787 : 127808729: 127808819: 127808488: 127815048 1038:102364590

ENSGOOOOO 126106 : TMEM53 :chrl : - ENSG00000001167:NFYA:chr6:+:41048549:41048636:41 ENSG00000163466:ARPC2:chr2:+:219103386:219103573:219

:45120611:45120881:45111136:45125845 046903:41051784 093573:219110142

ENSG00000147852:VLDLR:chr9:+:2651414:2651498:26 ENSG00000167978:SRRM2:chrl6:+:2818505:2818600:28 ENSG00000138606:SHF:chrl5:-

50516:2651873 18262:2818997 :45464344:45464516:45464200:45467416

ENSG00000072310: SREBF1 :chrl7:- ENSG00000102977:ACD:chrl6:- ENSG00000186812:ZNF397:chrl8:+:32834195:32834366:328

: 17720861 : 17720905 : 17720771 : 17721009 :67692457:67692544:67692265:67692622 23257:32837891

ENSG00000129103:SUMF2:chr7:+:56142278:56142332:5 ENSGOOOOO 167110 : G0LGA2 : chr9 : - ENSG00000074266:EED:chrll:+:85979497:85979603:859753

6141911:56144526 : 131029472:131029553 : 131028604:131029736 05:85988021

ENSG00000112031:MTRFlL:chr6:- ENSG00000064042:LIMCHl:chr4:+:41689856:41689934: ENSG00000169727:GPSl:chrl7:+:80010250:80010335:80009

: 153312319: 153312551:153311230: 153313991 41687847:41691543 840:80011149

ENSG00000148399:DPH7:chr9:- ENSG00000136891:TEX10:chr9:- ENSG00000122367:LDB3:chrl0:+:88441192:88441560:88439

: 140459344: 140459410: 140459058: 140459536 : 103091421: 103091557: 103090244: 103102538 914:88445434

ENSG00000113649:TCERGl:chr5:+: 145889629: 1458897 ENSG00000172366:MCRIP2:chrl6:+:696471:696608:692 ENSG00000114956:DGUOK:chr2:+:74177753:74177859:7415

23:145888808:145890003 249:697782 4179:74185272

ENSG00000082805:ERCl:chrl2:+: 1313666: 1313678: 129 ENSG00000186998:EMIDl:chr22:+:29650191:29650276: ENSG00000165322:ARHGAP12:chrl0:- 9218:1345934 29639478:29651259 :32128232:32128247:32120728:32128564

ENSG00000141699:FAM134C:chrl7:- ENSG00000117859:OSBPL9:chrl:+:52205814:52205883: ENSG00000141556:TBCD:chrl7:+:80858526:80858607:80851 :40739851:40739882:40738909:40744073 52179751:52211207 508:80869633 ENSG00000196914:ARHGEF12:chrll:+: 120280102: 1202 ENSG00000185347:C14orf80:chrl4:+: 105962216: 105962 ENSG00000181163:NPMl:chr5:+: 170827156: 170827214: 1708 80159:120278532:120291461 423:105960270:105963693 15010:170832305

ENSG00000156958:GALK2:chrl5:+:49574183:49574282 ENSG00000284024:RP11- ENSG00000169727:GPSl:chrl7:+:80010131:80010335:80009 :49531564:49584523 398C13:chrlO:+: 14884132: 14884845: 14882156: 14885369 840:80011149 ENSG00000164896:FASTK:chr7:- ENSG00000160325:CACFDl:chr9:+: 136330443: 1363305 ENSG00000222011:FAM185A:chr7:+: 102412855: 102412897: : 150774187: 150774323: 150773919: 150774396 69:136328677:136333042 102401858:102417699 ENSG00000108599:AKAP10:chrl7:- ENSG00000112320:SOBP:chr6:+: 107954717: 107956673: ENSG00000130958:SLC35D2:chr9:- : 19844199: 19844323: 19843162: 19845138 107854814:107979410 :99098998:99099066:99086451:99122435 ENSG00000003756:RBM5:chr3:+:50147811:50147896:50 ENSGOOOOO 111196 :MAGOHB : chrl 2 : - ENSG00000107263:RAPGEFl:chr9:- 147121:50148111 : 10761696: 10761982: 10760535: 10762429 : 134480317: 134480575: 134477536: 134497182

ENSG00000105552:BCAT2:chrl9:- ENSG00000164211:STARD4:chr5:- ENSG00000168646:AXIN2:chrl7:- :49310256:49310331 :49303554:49314240 : 110837659: 110837786: 110836814: 110842027 :63532986:63533181:63532671:63533441 ENSG00000109339:MAPK10:chr4:- ENSG00000178053:MLFl:chr3:+: 158306648: 158306713: ENSG00000065882:TBClDl:chr4:+:38054726:38054846:3805 : 87019676 : 87020438 : 86989108 : 87022204 158289136:158310222 1519:38055819

ENSG00000093167:LRRFIP2:chr3 ENSG00000006194:ZNF263:chrl6:+:3335058:3335239:33 ENSG00000171307:ZDHHC16:chrl0:+:99213555:99213603:9

:37114280:37114373:37107433:37116514 34205:3336022 9212260:99214470

ENSG00000025772:TOMM34:chr20:- ENSG00000214022 :REPIN1 :chr7 :+: 150067802 : 15006797 ENSG00000171703:TCEA2:chr20:+:62695244:62695302:6269

:43577370:43577518:43572220:43580473 3:150066957:150068316 4737:62697828

ENSG00000167632 : TRAPPC9 : chr8 : - ENSGOOOOO 182272 :B4GALNT4:chrl 1 :+: 380670 :380951 : ENSG00000183696:UPPl:chr7:+:48139266:48139384:481344

: 141436713: 141436740: 141415797: 141445210 380445:381668 24:48141420

ENSG00000129675:ARHGEF6:chrX:- ENSG00000163138:PACRGL:chr4:+:20715054:20715162: ENSG00000162961:DPY30:chr2:-

: 135760094: 135760115: 135758876: 135761693 20706437:20728907 :32108454:32108531:32095021:32117060

ENSG0000011923 l:SENP5:chr3:+: 196654666: 196654750 ENSGOOOOO 163660 : CCNL 1 : chr3 : - ENSGOOOOO 128159 : TUB GCP6 : chr22 : -

: 196650422: 196656503 : 156867075: 156867174: 156866378: 156867273 :50658679:50660303:50658444:50660456

ENSG00000102081:FMRl:chrX:+: 147019617: 147019680 ENSG00000115504:EHBPl:chr2:+:63176228:63176297:6 ENSG00000166949:SMAD3:chrl5:+:67457590:67457722:674 : 147019119: 147022094 3175451:63182651 57426:67459116

ENSG00000136856:SLC2A8:chr9:+: 130159654: 1301598 ENSG00000037474:NSUN2:chr5:- ENSG00000007047:MARK4:chrl9:+:45801400:45801480:458

17:130159565:130162185 :6622128:6622213:6620411:6623326 01212:45803068

ENSG00000089159:PXN:chrl2:- ENSG00000158636:EMSY:chrll:+:76246938:76247103:7 ENSG00000060138:YBX3:chrl2:-

: 120657009: 120657894: 120653464: 120659425 6239510:76248838 : 10862506: 10862713 : 10856747 : 10865809

ENSG00000116698:SMG7:chrl:+: 183516237: 183516387: ENSGOOOOO 163608 :NEPRO : chr3 : - ENSG00000005379:TSPOAPl:chrl7:-

183514447:183518342 : 112729489: 112729551 : 112727277: 112729891 :56381698:56381760:56379808:56382421

ENSG00000101190:TCFL5:chr20:- ENSG00000183077:AFMID:chrl7:+:76198783:76198832: ENSG00000163644:PPMlK:chr4:-

:61488746:61488990:61485509:61491476 76187141:76202991 :89189892:89190058:89186287:89198294

ENSG00000005436:GCFC2:chr2:- ENSGOOOOO 105426 :PTPRS :chrl 9: - ENSG00000087157:PGSl:chrl7:+:76411032:76411108:76400

:75919102:75919226:75917845:75921366 :5218797:5218809:5218543:5219320 170:76415626

ENSG00000072518:MARK2:chrl 1 :+:63675731 :63675776 ENSG00000198556:ZNF789:chr7:+:99081652:99081766:9 ENSG00000002016:RAD52:chrl2:-

:63673586:63676348 9077410:99084098 : 1035961: 1036112: 1034691: 1036310

ENSG00000006125:AP2Bl:chrl7:+:33997875:33997917: ENSG00000119979:FAM45A:chrl0:+: 120864275: 120864 ENSG00000139496:NUP58:chrl3:+:25911073:25911172:2590

33984810:33998772 534:120863709:120864822 5696:25912773

ENSG00000137210:TMEM14B:chr6:+: 10770309: 107704 ENSG00000015153:YAF2:chrl2:- ENSGOOOOO 124006 :0B SL 1 :chr2: - 37:10751467:10829239 :42604156:42604256:42555567:42604349 :220422064:220422340:220421445:220423946

ENSGOOOOO 184497 :TMEM255B :chrl3 :+: 114507857 : 114 ENSG00000152154:TMEM178A:chr2:+:39931220:399313 ENSG00000161677:JOSD2:chrl9:- 508001 : 114504785 : 114514708 34:39893514:39944149 :51010830:51010956:51009829:51013542

ENSG00000107679:PLEKHAl:chrl0:+: 124187791: 12418 ENSG00000101158:NELFCD:chr20:+:57568678:5756873 ENSG00000100350:FOXRED2:chr22:- 7936:124186547:124189139 0:57568167:57569164 :36900144:36900414:36897454:36900561

ENSG00000122034:GTF3A:chrl3:+:28006867:28006941: ENSG00000149100:EIF3M:chrll:+:32610557:32610681:3 ENSG00000146416:AIGl:chr6:+: 143605246: 143605362: 14348

28004758:28008275 2605475:32611092 6320:143654418

ENSG00000140905:GCSH:chrl6:- ENSG00000164548:TRA2A:chr7:- ENSG00000167110:GOLGA2:chr9:-

:81118067:81118199:81116568:81124205 :23561739:23562051:23561459:23571407 : 131035063: 131035144: 131030803: 131036128

ENSG00000119866 :BCLllA:chr2:- ENSG00000138162:TACC2:chrl0:+: 123972856: 12397289 ENSG00000204954:C12orf73:chrl2:-

:60687816:60688879:60679801:60689416 2:123971223:123974905 : 104347191: 104347312: 104345408: 104350408

ENSG00000161996:WDR90:chrl6:+:710057:710161:709 ENSG00000140575:IQGAPl:chrl5:+:90974452:90974484 ENSG00000087076:HSD17B14:chrl9:-

376:710611 :90972898:90976950 :49335922:49336009:49318398:49337532

ENSGOOOOO 114439 :BBX:chr3 :+:107508633 :107508723 :1 ENSGOOOOO 132466 :ANKRD 17 : chr4 : - ENSG00000168803:ADAL:chrl5:+:43639213:43639294:43638 07497366:107510086 :74005247:74006000:74000979:74007457 178:43641104

ENSG00000111271:ACAD10:chrl2:+: 112191575: 112191 ENSG00000143847:PPFIA4:chrl:+:203018803:203018895 ENSG00000173681:CXorf23:chrX:-

719:112187149:112193471 :203018108:203020896 : 19953926: 19954016: 19948058: 19955622

ENSG00000157800:SLC37A3:chr7:- ENSG00000167522:ANKRDll:chrl6:- ENSG00000148660:CAMK2G:chrl0:-

: 140045015: 140045063: 140037149: 140045668 :89352446:89352594:89341599: 89354935 :75585036:75585105:75583842:75587846

ENSG00000169592:IN080E:chrl6:+:30015888:30015978 ENSGOOOOO 135723 :FHOD 1 :chrl6 :- ENSG00000117054: ACADM:chrl:+:76199212:76199313:7619

:30012851:30016541 :67270313:67270337:67268375:67270459 8607:76200475

ENSG00000133687:TMTCl:chrl2:- ENSGOOOOO 168066 : SF 1 :chrl 1 : - ENSG00000060069:CTDPl:chrl8:+:77488906:77489069:7747

:29736339:29736507:29725151:29757110 :64540901:64540977:64537880:64543969 8016:77513651

ENSG00000068120:CC)ASY:chrl7:+:40717000:40717065 ENSG00000075234:TTC38:chr22:+:46665038:46665186:4 ENSG00000088298:EDEM2:chr20:-

:40716595:40717244 6664488:46668231 :33719444:33719586:33714178:33725682

ENSG00000102125:TAZ:chrX:+: 153648043: 153648085:1 ENSG00000107771:CCSER2:chrl0:+:86259630:86259715 ENSG00000186625:KATNAl:chr6:-

53647962:153648370 :86185649:86273204 : 149922729: 149922935 : 149919486: 149924403

ENSG00000125772:GPCPDl:chr20:- EN SG00000073712 :FERMT2 :chrl 4 : - ENSG00000144857:BOC:chr3:+: 112991915: 112992188: 11299

:5566839:5566915:5564968:5573972 :53327731:53327752:53327183:53331118 1550:112993221

ENSG00000183963:SMTN:chr22:+:31496870:31496939: ENSG00000081760:AACS:chrl2:+: 125603186: 125603311 ENSG00000130803:ZNF317:chrl9:+:9268655:9268751:92680

31495882:31500301 : 125599103:125618548 70:9269501

ENSG00000139116:KIF21A:chrl2:- ENSG00000168970: MJD7- ENSG00000115504 :EHBPl:chr2:+:63215065:63215173:632 9772:39705355:39711874 PLA2G4B:chrl5:+:42135323:42135 06

:39709733:3970 421:42134789:421358

73 470:63217850

ENSG00000105186:ANKRD27:chrl9:- ENSG00000070501:POLB:chr8:+:42196529:42196587:42 ENSG00000163939:PBRMl:chr3:-

:33137364:33137521:33135385:33140587 196203:42202470 : 52592264:52592429:52584833:52595782

ENSG00000105538:RASIPl:chrl9:- EN SGOOOOO 124789 :NUP 153: chr6 : - ENSG00000148655:C10orfll:chrl0:+:78295555:78295745:78

:49230041:49230145:49228217:49232193 : 17669205: 17669259: 17665616: 17669523 084243:78316966

ENSG00000139428:MMAB:chrl2:- ENSG00000070814:TCOF1 :chr5 :+: 149771106: 149771358 ENSG00000099957:P2RX6:chr22:+:21380299:21380618:2138

: 109999047: 109999134: 109998909: 109999584 : 149769586: 149771519 0187:21380708

ENSG00000004866:ST7:chr7:+: 116830186: 116830322: 11 ENSG00000139624:CERS5:chrl2:- ENSG00000159445:THEM4:chrl:-

6829447:116830887 :50529215:50529435:50528485:50529514 : 151862458: 151862690: 151861849: 151867483

ENSG00000130751:NPASl:chrl9:+:47544235:47544383: ENSG00000166377:ATP9B:chrl8:+:77132824:77132882: ENSG00000019144:PHLDBl:chrll:+: 118515364: 118515409:1

47543808:47546067 77119462:77133897 18514892:118516073

ENSG00000179912:R3HDM2:chrl2:- ENSG00000127663:KDM4B:chrl9:+:5119128:5119230:5 ENSG00000168785:TSPAN5:chr4:-

: 57666235:57666337:57663777: 57674140 110829:5119663 :99407888:99408035:99403326:99428828

ENSG00000119979:FAM45A:chrl0:+: 120864275: 120864 ENSG00000147364:FBX025:chr8:+:417719:417746:4131 ENSG00000152154:TMEM178A:chr2:+:39934188:39934326:3

534:120863709:120867479 50:418714 9893514:39944149

ENSG00000144504:ANKMYl:chr2:- ENSG00000141376:BCAS3:chrl7:+:59457866:59457932: ENSG00000132781:MUTYH:chrl:-

:241421599:241421678:241420514:241439374 59445855:59469337 :45795560:45795740:45795109:45796187

ENSG00000108651 :UTP6 :chrl7: - ENSG00000169592:IN080E:chrl6:+:30012532:30015978: ENSG00000119729:RHOQ:chr2:+:46803225:46803390:46770

:30193673:30193734:30192457:30195064 30012361:30016541 951:46808066

ENSG00000147044:CASK:chrX:- ENSG00000178104:PDE4DIP:chrl:- ENSG00000074266:EED:chrll:+:85977124:85977258:859753

:41416284:41416353:41414888:41419031 : 144871695: 144871881:144868172: 144873876 05:85988021

ENSG00000143537:ADAM15:chrl:+: 155034379: 155034 ENSG00000073008:PVR:chrl9:+:45162009:45162168:451 ENSG00000150712:MTMR12:chr5:-

593:155033308:155034720 57286:45164558 :32233878:32234040:32230453:32239106

ENSG00000168958:MFF:chr2:+:228211941:228212100:2 ENSG00000133612:AGAP3:chr7:+: 150817606: 150817832 ENSG00000106638:TBL2:chr7:- 28207535:228220392 : 150817232: 150819811 :72990870:72991031 :72988843 :72992749

ENSG00000059145:UNKL:chrl6:- ENSG00000114859:CLCN2:chr3:- ENSGOOOOO 198276:UCKL 1 :chr20 : - : 1463846: 1464010: 1453345: 1464615 : 184071449: 184071583: 184071210: 184071888 :62575005:62575022:62573845:62575749 ENSG00000122481:RWDD3:chrl:+:95712097:95712213: ENSG00000182979:MTAl:chrl4:+: 105933043: 105933079 ENSG00000089472:HEPH:chrX:+:65474876:65474983:65428 95699871:95712311 : 105932915: 105935803 088:65478681

ENSG00000155970:MICU3:chr8:+: 16973951:16974109:1 ENSGOOOOO 151092 :NGLY1 :chr3 :- ENSG00000060971 : ACAA1 :chr3 :- 6971710:16976215 :25761620:25761682:25761126:25770623 :38173086:38173129:38170879:38173416

ENSG00000186575:NF2:chr22:+:30079008:30079053:30 ENSG00000114841 :DNAHl:chr3:+:52432047:52432178:5 ENSG00000168958:MFF:chr2:+:228207460:228207535:22820

077590:30090740 2431893:52432865 5096:228211941

ENSG00000258653:RP5- ENSG00000196781:TLEl:chr9:- ENSG00000133612:AGAP3:chr7:+: 150817606: 150817832: 150

1021I20:chrl4:+:74389195:74389400:74388909:74390097 :84267128:84267203:84249216:84300590 817232:150820880

ENSG00000198909:MAP3K3:chrl7:+:61712068:6171216 ENSG00000139624:CERS5:chrl2:- ENSG00000181929:PRKAGl:chrl2:-

1:61710162:61723393 :50526744:50527851:50524477:50528328 :49399525:49399664:49399326:49406844

ENSG00000138794 : C ASP6 : chr4 : - ENSG00000164548:TRA2A:chr7:- ENSG00000087274:ADDl:chr4:+:2911065:2911158:2910331:

: 110617565: 110617642: 110615856: 110618777 :23561750:23562051:23561459:23571407 2916610

ENSG00000117335:CD46:chrl:+:207941123:207941168: ENSGOOOOO 146215 : CRIP3 : chr6 : - ENSG00000144935:TRPC1 :chr3 :+: 142496473 : 142496605 : 142

207940540:207943665 :43273804:43273862:43273613:43273956 467302:142521010

ENSG00000076555:ACACB:chrl2:+: 109685410: 1096855 ENSG00000163681:SLMAP:chr3:+:57911571:57911661:5 ENSG00000072518:MARK2:chrll:+:63671457:63671619:636

08:109684253:109687788 7908750:57913022 70630:63672257

ENSG00000120860:WASHC3:chrl2:- ENSG00000092421:SEMA6A:chr5:- ENSG00000177990:DPY19L2:chrl2:-

: 102443966: 102444069: 102439897: 102455689 :115808580:115808631 :115803443 :115808768 :63974441:63974616:63964637:63976185

ENSG00000168958:MFF:chr2:+:228217229:228217289:2 ENSG00000083535:PIBFl:chrl3:+:73547728:73547813:7 ENSG00000198208:RPS6KLl:chrl4:-

28205096:228220392 3505405:73572959 :75375803:75375893:75375635:75376245

ENSG00000090857:PDPR:chrl6:+:70165204:70165322:7 ENSG00000168763:CNNM3:chr2:+:97497705:97497805: ENSG00000139793:MBNL2:chrl3:+:98018712:98018807:980

0164447:70166053 97494871:97498288 09889:98043575

ENSG00000118197:DDX59:chrl:- ENSG00000093167 :LRRFIP2 :chr3 :- ENSG00000184277:TM2D3:chrl5:-

:200619552:200619804:200618354:200628154 :37107714:37107816:37107433:37116514 : 102191898: 102191976: 102190364: 102192473

ENSG00000066056:TIEl:chrl:+:43773466:43773595:437 ENSG00000122490:PQLCl:chrl8:- ENSG00000080802:CNOT4:chr7:-

73243:43774656 :77690227:77690311:77664183:77693968 : 135048605: 135048818: 135047938: 135078669

ENSG00000162385:MAGOH:chrl:- ENSG00000010244:ZNF207:chrl7:+:30688486:30688534: ENSG00000119688:ABCD4:chrl4:- : 53699213:53699324:53694626: 53701248 30687986:30689932 :74756729:74756821:74756222:74756993 ENSG00000163697:APBB2:chr4:- ENSG00000007545:CRAMPl:chrl6:+: 1716073: 1716178: ENSG00000113649:TCERG1 :chr5:+: 145847903 : 145847966: 14 :40937093:40937156:40936716:40946881 1715139:1716422 5843356:145849106 ENSG00000112659:CUL9:chr6:+:43154697:43154833:43 ENSG00000153391:IN080C:chrl8:- ENSG00000166073:GPR176:chrl5:- 154193:43154983 :33067349:33067403:33060527:33077682 :40099206:40099459:40094455:40212055

ENSG00000150787:PTS:chrll:+: 112100930: 112100953:1 ENSGOOOOO 138674 : SEC31 A:chr4 : - ENSG00000154114:TBCEL:chrll:+: 120924259: 120924441: 12 12099396:112101348 :83782783:83782861:83778917: 83783686 0918376:120925760

ENSG00000167515:TRAPPC2L:chrl6:+:88925752:88925 ENSGOOOOO 146067 :FAM193B :chr5 :- ENSG00000100280:APlBl:chr22:- 851:88925197:88926300 : 176974168: 176974229: 176966148: 176981249 :29735742:29735763:29735122:29736644 ENSGOOOOO 197226 : TB C 1D9B : chr5 : - ENSG00000185246:PRPF39:chrl4:+:45565626:45565961: ENSG00000164306:PRIMPOL:chr4:+: 185582927: 185583057: : 179294444: 179294495: 179292888: 179294777 45565431:45566089 185580591:185587070 ENSGOOOOO 125676 :TH0C2 :chrX:- ENSG00000110888:CAPRIN2:chrl2:- ENSG00000112357:PEX7:chr6:+: 137193335:137193391:1371 : 122757494: 122757560: 122757134: 122757637 :30872012:30872159:30869610:30873744 47607:137219279

ENSG00000137501:SYTL2:chrll:- ENSG00000168958:MFF:chr2:+:228211941:228212100:2 ENSG00000047932:GOPC:chr6:-

: 85422155:85422275:85420543: 85429832 28205096:228220392 : 117898610: 117898634: 117896515: 117900062

ENSG00000111907:TPD52Ll:chr6:+: 125578243: 1255783 ENSG00000099998:GGT5:chr22:- ENSG00000135407:AVIL:chrl2:-

04:125574901:125583979 :24616459:24616552:24616084:24620963 :58197306:58197452:58197174:58200142

ENSG00000151923:TIALl:chrl0:- ENSG00000145730:PAM:chr5:+: 102309819: 102310140:1 ENSG00000123636:BAZ2B:chr2:-

: 121339982: 121340050: 121339522: 121341433 02296933:102325975 : 160284451 : 160284553 : 160269056: 160284821

ENSG00000112983:BRD8:chr5:- ENSGOOOOO 137726 :FXYD6 :chrl 1 : - ENSG00000122481:RWDD3:chrl:+:95709766:95710271:9569

: 137502206: 137502299: 137501797: 137503622 : 117711058: 117711083: 117710545: 117711862 9871:95712311

ENSG00000112305:SMAPl:chr6:+:71501391:71501472:7 ENSG00000112305:SMAPl:chr6:+:71501391:71501472:7 ENSG00000168487:BMPl:chr8:+:22049747:22049848:220496

1483128:71546643 1483128:71508359 64:22051570

ENSG00000136643:RPS6KCl:chrl:+:213405465:213405 ENSG00000105865 :DUS4L:chr7 :+: 107211589: 107211711 ENSG00000187239:FNBPl:chr9:-

598:213349835:213414044 : 107207631:107215632 : 132686122: 132686218: 132678259: 132687238

ENSG00000189367:KIAA0408:chr6:- ENSG00000168487:BMPl:chr8:+:22056776:22056900:22 ENSG00000139372:TDG:chrl2:+: 104376913: 104376996: 1043

: 127772426: 127772462: 127771497: 127774991 054933:22058630 76712:104377072

ENSG00000117114:ADGRL2:chrl:+:82418670:82418709 ENSG00000175287:PHYHDl:chr9:+: 131702647: 1317027 ENSG00000204842:ATXN2:chrl2:-

:82417826:82421560 76:131698924:131703723 : 111953957: 111954167: 111951343: 111956052

ENSG00000129116:PALLD:chr4:+: 169817699: 16981775 ENSG00000176444:CLK2:chrl:- ENSG00000143442:POGZ:chrl:- 0:169815828:169819643 : 155235650: 155235745: 155234565: 155237800 : 151413403: 151413562: 151403317: 151414556

ENSG00000172661:WASHC2C:chrl0:+:46254762:46254 ENSG00000135390:ATP5G2:chrl2:- ENSG00000100523:DDHDl:chrl4:- 849:46252587:46258835 :54063654:54063898:54059212:54066359 :53560033:53560162:53558650:53570400 ENSG00000178209:PLEC:chr8:- ENSG00000148057:IDNK:chr9:+:86243787:86243874:86 ENSG00000067066:SP100:chr2:+:231314275:231314425:2313 : 145012568: 145012583: 145012408: 145012798 238136:86256462 13865:231325976 ENSG00000158201:ABHD3:chrl8:- ENSG00000177479:ARIH2:chr3:+:48982568:48982614:48 ENSG00000171606:ZNF274:chrl9:+:58697063:58697205:586 : 19263880: 19263926: 19239304: 19282276 965246:48999044 95365:58698313 ENSG00000169062:UPF3A:chrl3:+: 115051776: 1150518 ENSG00000127054:INTSll:chrl:- ENSG00000106771:TMEM245:chr9:- 75:115047602:115051993 : 1258560: 1258667: 1256473: 1259960 : 111848276: 111848300: 111843223: 111849452

ENSG00000103671:TRIP4:chrl5:+:64706283:64706410:6 ENSG00000234745:HLA-B:chr6:- ENSG00000105552:BCAT2:chrl9:-

4702027:64710739 :31322883:31323000:31322442:31323093 :49309773 :49309974:49303554:49314240

ENSG00000165475 :CRYL 1 :chrl 3 : - ENSG00000133026:MYH10:chrl7:- ENSG00000079819:EPB41L2:chr6:-

:21013731:21013893:21006435:21063508 :8479960:8479990:8473130:8480553 : 131197813: 131197915: 131191266: 131199243

ENSG00000007541 :PIGQ:chrl6:+:631198:631341 :63097 ENSG00000059588:TARBP1 :chrl :- ENSG00000243696:RP5-966Ml:chr3:-

2:632882 :234534127:234534299:234529583:234536926 : 52848224:52848379:52848087:52850899

ENSGOOOOO 150403 :TMC03 :chrl3 :+: 114201614: 1142016 ENSGOOOOO 188906 :LRRK2:chrl2:+:40707773 :40707975 : ENSG00000143157:POGK:chrl:+: 166816730: 166816829: 1668 94:114193822:114202617 40704451:40709013 10325:166818174

ENSG00000134780:DAGLA:chrl 1 :+:61503032:61503116 ENSG00000156958:GALK2:chrl5:+:49575762:49575915: ENSG00000203797:DDO:chr6:- :61502474:61503210 49531564:49584523 : 110734493 : 110734669: 110729645: 110736669 ENSG00000137501:SYTL2:chrll:- ENSG00000169919:GUSB:chr7:- ENSG00000187239:FNBPl:chr9:- : 85425455:85425550:85420543:85429832 :65444713:65444898:65441189:65445210 : 132686122: 132686305 : 132678259: 132687238 ENSG00000107771:CCSER2:chrl0:+:86259630:8625971 ENSG00000168958:MFF:chr2:+:228217229:228217289:2 ENSG00000182923:CEP63:chr3:+: 134266176: 134266314: 134 5:86237420:86273204 28207535:228220392 265130:134267903 ENSG00000178209:PLEC:chr8:- ENSG00000137216:TMEM63B:chr6:+:44103064:4410310 ENSG00000132470:ITGB4:chrl7:+:73751135:73751294:7375 : 144996671 : 145000052: 144996563 : 145000951 3:44102833:44104085 0896:73751781

ENSG00000169727:GPSl:chrl7:+:80010253:80010335:8 ENSG00000089159:PXN:chrl2:- ENSG00000160285:LSS:chr21:-

0009840:80011149 : 120657009: 120657894: 120653076: 120659425 :47616115:47616181:47615670:47625749

ENSG00000092871 :RFFL :chrl7: - ENSG00000124222:STX16:chr20:+:57246219:57246353:5 ENSG00000132694:ARHGEFll:chrl:-

: 33348389:33348800:33344625: 33353392 7245659:57248686 : 156941488: 156941608: 156939835: 156946774

ENSG00000175287:PHYHDl:chr9:+: 131702877: 1317029 ENSG00000114948:ADAM23:chr2:+:207474633:2074747 ENSG00000253710:ALGll:chrl3:+:52598141:52599073:5259

94:131700057:131703723 24:207460886:207482302 3279:52602454

ENSG00000065802:ASBl:chr2:+:239344351:239344654: ENSG00000276087:RP11- ENSG00000103197:TSC2:chrl6:+:2132436:2132505:2131799: 239342336:239352982 507M3:chr2:+:24357988:24358057:24347330:24387067 2133695 ENSG00000161791:FMNL3:chrl2:- ENSG00000196873:CBWD3:chr9:+:70871836:70871896: ENSG00000007376:RPUSDl:chrl6:- :50040421:50040536:50039686:50040668 70863813:70873447 :837067:837179:836928:837353 ENSG00000135424:ITGA7:chrl2:- ENSG00000174796:THAP6:chr4:+:76465068:76465169:7 ENSG00000103126:AXINl:chrl6:- :56094045:56094177:56093773:56094682 6447071:76467618 :341189:341297:339607:343487 ENSG00000107164:FUBP3:chr9:+: 133510053: 133510125 ENSG00000176261:ZBTB80S:chrl:- ENSG00000160813:PPPlR35:chr7:- : 133507665: 133511385 :33100302:33100393:33087549:33116033 : 100033253: 100033390: 100033156: 100033470 ENSG00000107186:MPDZ:chr9:- ENSG00000163681:SLMAP:chr3:+:57857362:57857425:5 ENSG00000101639:CEP192:chrl8:+: 13103873: 13103966: 131 : 13147546: 13147657: 13140148: 13150509 7850584:57875767 03587:13104982 ENSG00000113734:BNIPl:chr5:+: 172578568: 172578697 ENSG00000137501: SYTL2 :chrl 1 : - ENSG00000079974:RABL2B:chr22:- : 172573961:172581324 :85428525:85428573:85425550:85429832 :51207882:51207980:51207552:51214199

ENSG00000100599:RIN3:chrl4:+:93142877:93142951:93 ENSG00000093167 :LRRFIP2 :chr3 :- ENSG00000117791 :MARC2:chrl:+:220955119:220955274:22 125814:93151331 :37132957:37133029:37125297:37136282 0936392:220957260

ENSG00000175470:PPP2R2D:chrl0:+: 133748397: 13374 ENSGOOOOO 116991 : SIPA 1L2 :chrl : - ENSG00000108175:ZMIZl:chrl0:+:81070680:81070941:8106

8510:133748059:133753534 :232539870:232539924:232539317:232551239 7328:81072398

ENSG00000132199:ENOSFl:chrl8:- ENSG00000182670:TTC3:chr21:+:38529462:38529516:38 ENSG00000101294:HM13:chr20:+:30155880:30156083:30154

:678695:678737:677872:683245 529208:38532000 098:30156922

ENSG00000170049:KCNAB3:chrl7:- ENSG00000135297:MT01:chr6:+:74190015:74190090:74 ENSG00000151247:EIF4E:chr4:-

:7826773 :7826862:7826497 :7827028 189849:74190397 :99807604:99807697:99806212:99808229

ENSG00000070081:NUCB2:chrl 1 :+: 17336932: 17337022 ENSGOOOOOH4956:DGUOK:chr2:+:74184251:74184367: ENSG00000182979:MTAl:chrl4:+: 105912003: 105912189: 105

:17333667:17351673 74154179:74185272 911848:105916394

ENSG00000203666:EFCAB2:chrl:+:245165422:2451655 ENSG00000178691:SUZ12:chrl7:+:30274635:30274704:3 ENSG00000133872:SARAF:chr8:-

34:245133745:245222687 0267505:30293165 :29931392:29931567:29927575:29940362

ENSG00000160767:FAM189B:chrl:- ENSG00000110514:MADD:chrll:+:47330530:47330593: ENSG00000146574:CCZlB:chr7:-

: 155223874: 155223985: 155223523: 155224190 47330250:47330831 :6852606:6852668:6851694:6854394

ENSG00000068305:MEF2A:chrl5:+: 100243566: 1002435 ENSG00000172785:CBWDl:chr9:- ENSG00000100209:HSCB:chr22:+:29141851:29141996:29140

90:100230633:100246933 : 146101: 146158: 135030: 152033 692:29147228

ENSG00000125454:SLC25A19:chrl7:- ENSG00000196961:AP2Al:chrl9:+:50305790:50305856: ENSG00000072110:ACTNl:chrl4:-

:73273433:73273564:73269720:73279503 50305398:50306205 :69345705:69345786:69345240:69346678

ENSG00000143537:ADAM15:chrl:+: 155034379: 155034 ENSG00000164199:ADGRVl:chr5:+:90445846:90446038 ENSG00000165795:NDRG2:chrl4:-

451:155033965:155034720 :90398157:90459598 :21491022:21491064:21490656:21491399

ENSG00000073921 :PICALM:chrl 1 : - ENSGOOOOO 116731 :PRDM2:chrl :+: 14095612: 14095668: 1 ENSG00000100320:RBFOX2:chr22:-

:85701292:85701421:85695016:85707868 4075982:14099572 :36152151:36152191:36142608:36155934

ENSG00000100503:NIN:chrl4:- ENSG00000114026:OGGl:chr3:+:9800870:9800970:9798 ENSG00000136717:BINl:chr2:-

:51197640:51197701:51196441:51202233 500:9807492 : 127809830: 127809938: 127808819: 127810997

ENSG00000071564:TCF3:chrl9:- ENSG00000175575:PAAFl:chrll:+:73598075:73598144: ENSG00000159761:C16orf86:chrl6:+:67701198:67701428:67 : 1632330: 1632404: 1627425: 1646353 73589864:73598398 700975:67701780 ENSG00000139567:ACVRLl:chrl2:+:52307342:5230755 ENSG00000166169:POLL:chrl0:- ENSG00000163125:RPRD2:chrl:+: 150414356: 150414434: 150 4:52307134:52308222 : 103345618: 103345913: 103340173: 103347002 413499:150415706

ENSG00000062194:GPBPl:chr5:+:56532939:56532999:5 ENSG00000099864:PALM:chrl9:+:740351:740483:73607 ENSG00000089157:RPLP0:chrl2:-

6531859:56542126 8:746284 : 120636356: 120636573 : 120635265: 120636656

ENSG00000141446:ESC01:chrl8:- ENSG00000165630:PRPF18:chrl0:+: 13639644: 13639671: ENSGOOOOO 113163 : COL4A3BP : chr5 : -

: 19120537: 19120661: 19119970: 19140819 13639535:13642243 :74695134:74695212:74685512:74696029

ENSG00000122490:PQLCl:chrl8:- ENSG00000132153:DHX30:chr3:+:47857452:47857618:4 ENSG00000197694:SPTANl:chr9:+: 131355261: 131355321: 13

:77693968:77694022:77679400:77703328 7852201:47859511 1353904:131356453

ENSG00000100105 :P ATZ 1 : chr22 : - ENSG00000133816:MICAL2:chrll:+: 12277189: 12277297 ENSG00000183077:AFMID:chrl7:+:76198783:76198832:7618

:31724772:31724910:31723295:31731677 : 12261132: 12278331 7141:76202026

ENSG00000073921 :PICALM:chrl 1 : - ENSG00000157734:SNX22:chrl5:+:64444441:64444525: ENSG00000110514:MADD:chrll:+:47310518:47310578:4730

:85701292:85701442:85695016:85707868 64444049:64444836 8085:47310941

ENSG00000161956:SENP3:chrl7:+:7469011:7469081:74 ENSGOOOOO 160613 :PCSK7 :chrl 1 : - ENSG00000091009:RBM27:chr5 :+: 145631273 : 145631438: 145

68904:7470243 : 117078369: 117078451 : 117077876: 117078685 616995:145634505

ENSG00000067066:SP100:chr2:+:231314886:231314970: ENSGOOOOO 139620 :KANSL2:chrl 2 : - ENSG00000127952:STYXLl:chr7:-

231313865:231325976 :49072818:49072933:49065745:49073437 :75643059:75643205:75634722:75651168

ENSG00000143434:SEMA6C:chrl:- ENSG00000095485:CWF19Ll:chrl0:- ENSG00000168802:CHTF8:chrl6:-

: 151108923: 151109055: 151108639: 151109332 : 102016018: 102016233: 102013296: 102027327 :69154955:69155073:69154552:69155338

ENSG00000068724:TTC7A:chr2:+:47178740:47178872:4 ENSG00000133794:ARNTL:chrll:+: 13376779: 13376843: ENSG00000095203:EPB41L4B:chr9:-

7177665:47183977 13375995:13378285 : 111947768: 111947885 : 111945077: 111954557

ENSG00000168256:NKIRAS2:chrl7:+:40174582:401746 ENSG00000124193:SRSF6:chr20:+:42087792:42088060:4 ENSG00000156414:TDRD9:chrl4:+: 104516201: 104516274: 10 58:40174490:40175671 2087149:42088410 4516017:104518317 ENSG00000132199:ENOSFl:chrl8:- ENSG00000197343:ZNF655:chr7:+:99160810:99160889:9 ENSG00000169241 : SLC50A1 :chrl :+: 155109303 : 155109427 : 1 :691203:691276:691106:693881 9160117:99161485 55108852:155110036

ENSG00000183077:AFMID:chrl7:+:76201683:76201834: ENSGOOOOO 137601 :NEK1 :chr4 :- ENSG00000275052:PPP4R3B:chr2:-

76198832:76202026 : 170359233: 170359410: 170354816: 170384393 :55805382:55805478:55804492:55806814

ENSG00000064655:EYA2:chr20:+:45700823:45700891:4 ENSG00000006194:ZNF263:chrl6:+:3335680:3335754:33 ENSG00000029363 :BCLAF1 :chr6:-

5644936:45717877 34205:3336022 : 136590278: 136590441 : 136589477: 136590574

ENSG00000169062:UPF3A:chrl3 :+: 115056963 : 1150570 ENSG00000110921:MVK:chrl2:+: 110019199: 110019355: ENSG00000122678:POLM:chr7:- 19:115052104:115057108 110017751:110023826 :44113729:44114129:44113624:44118338

ENSG00000196712:NFl:chrl7:+:29694242:29694296:29 ENSG00000005801:ZNF195:chrll:- ENSG00000136280:CCM2:chr7:+:45111348:45111471:451095

687721:29701030 :3382972:3383119:3381795:3392204 60:45112324

ENSG00000100813: ACINI :chrl4:- ENSGOOOOO 134874 :DZIP 1 : chr 13 : - ENSG00000107317:PTGDS:chr9:+: 139873674: 139873853: 139

:23559190:23559310:23551045:23559730 :96251618:96251678:96246340:96258256 872144:139874397

ENSG00000166073:GPR176:chrl5:- ENSGOOOOO 111731 :C2CD5 :chrl2:- ENSG00000077232:DNAJC10:chr2:+: 183604271: 183604436:1

:40099206:40099398:40094455:40212055 :22611417:22611519:22610095:22622642 83601113:183605025

ENSG00000137814:HAUS2:chrl5:+:42852979:42853068: ENSG00000103449:SALLl:chrl6:- ENSG00000058063:ATP1 IB :chr3:+: 182620268: 182620354: 18

42851606:42853467 :51172598:51176056:51171463:51185076 2616560:182631648

ENSG00000169598:DFFB:chrl:+:3789577:3789701:3789 ENSG00000153250:RBMSl:chr2:- ENSG00000163138:PACRGL:chr4:+:20709425:20709493:207

136:3800070 : 161138767: 161138815: 161137875: 161141285 06437:20728907

ENSG00000093167:LRRFIP2:chr3 ENSG00000154114:TBCEL:chrll:+: 120924338: 12092444 ENSG00000099917:MED15:chr22:+:20929399:20929519:2092 :37107714:37107816:37107433:37114280 1:120918376:120925760 2918:20936897 ENSGOOOOO 112234 :FBXL4 :chr6: - ENSG00000143776:CDC42BPA:chrl:- ENSG00000157637:SLC38A10:chrl7:- : 99365249:99365595:99353546:99374352 :227247073 :227247112:227235711 :227257477 :79223869:79223893 :79220861 :79225292 ENSG00000147364:FBX025:chr8:+:382885:382935:3814 ENSG00000133816:MICAL2:chrll:+: 12277189: 12277297 ENSG00000015153:YAF2:chrl2:- 44:385614 : 12270793: 12278331 :42592937:42593037:42555567:42631400

ENSG00000119650:IFT43:chrl4:+:76524984:76525017:7 ENSG00000144283:PKP4:chr2:+: 159535092: 159535166:1 ENSG00000105698:USF2:chrl9:+:35760705:35760906:35760

6488737:76548637 59530512:159536940 602:35761349

ENSG00000102710:SUPT20H:chrl3:- ENSG00000139624:CERS5:chrl2:- ENSG00000061656:SPAG4:chr20:+:34206844:34206920:3420

: 37584688:37584792:37583946:37586328 :50526744:50526847:50524477:50528328 6642:34207116

ENSGOOOOO 117625 :RCOR3 :chrl:+:211486061 :21148617 ENSGOOOOO 136861 : CDK5RAP2 :chr9 : - ENSG00000173226:IQCB 1 :chr3 :-

7:211477482:211486765 : 123222849: 123222945: 123220900: 123230137 : 121491403: 121491560: 121489421: 121500589

ENSGOOOOO 106009 :BRAT 1 :chr7 :- ENSG00000134138:MEIS2:chrl5:- ENSG00000168961:LGALS9:chrl7:+:25970550:25970646:259

:2580463:2580528:2579522:2580612 :37388489:37388608:37387815:37390167 69374:25972339

ENSG00000124608:AARS2:chr6:- ENSG00000139631:CSAD:chrl2:- ENSG00000127419:TMEM175:chr4:+:942198:942403:941942:

: 44274985 :44275131 :44274768:44278730 :53564960:53565225:53564286: 53565665 944208

ENSG00000076685:NT5C2:chrl0:- ENSG00000198208:RPS6KLl:chrl4:- ENSGOOOOO 159063 : ALG8 :chrl 1 : -

: 104871501: 104871562: 104866463: 104934614 :75375803:75375893:75375635:75377950 :77849755:77849813:77838482:77850539

ENSG00000175224:ATG13:chrll:+:46685546:46685645: ENSGOOOOO 115084: SLC35F5 :chr2 :- ENSGOOOOO 124787:RPP40 :chr6 :-

46681035:46686398 : 114475329: 114475427: 114472772: 114476730 :4998949:4999075:4996654:5000042

ENSG00000141644:MBDl:chrl8:- ENSG00000138614:INTS14:chrl5:- ENSG00000005884:ITGA3:chrl7:+:48165588:48165730:4816

:47797838:47797910:47796188:47799046 :65899496:65899780:65897574:65903435 5233:48166473

ENSG00000126777:KTNl:chrl4:+:56130672:56130759:5 ENSG00000257218:GATC:chrl2:+: 120892735: 120892833 ENSGOOOOO 113240 : CLK4 : chr5 : -

6128330:56137446 : 120884632: 120894878 : 178046838: 178047674: 178045779: 178050256

ENSGOOOOO 100105 :P ATZ 1 : chr22 : - ENSG00000148187:MRRF:chr9:+:125048317:125048445: ENSG00000115760 :BIRC6:chr2:+:32815872:32816045:32800

:31724772:31724845:31723295:31731677 125047566:125054027 433:32818981

ENSG00000144935:TRPCl:chr3:+: 142455220: 142455375 ENSG00000105953:OGDH:chr7:+:44695916:44695961:44 ENSG00000166377:ATP9B:chrl8:+:77135393:77135426:7713

: 142443573 : 142467099 687358:44706334 4101:77137246

ENSG00000007541 :PIGQ:chrl6:+:631198:631341 :63097 ENSG00000139116:KIF21A:chrl2:- ENSG00000137411:VARS2:chr6:+:30887871:30887993:30887 2:632247 :39724043:39724064:39720126:39724547 625:30888109

ENSG00000100503:NIN:chrl4:- ENSG00000180098:TRNAUlAP:chrl:+:28887624:288877 ENSGOOOOO 128159 : TUB GCP6 : chr22 : - :51233024:51233114:51230682:51233497 72:28887244:28887857 :50658620:50660303:50658444:50660456 ENSGOOOOO 196792 : STRN3 :chrl4 :- ENSG00000116754:SRSFll:chrl:+:70696777:70696886:7 ENSG00000183077:AFMID:chrl7:+:76201683:76201819:7619 :31398406:31398517:31382863:31404368 0694238:70697541 8832:76202026 ENSG00000144744:UB A3 :chr3 :- ENSG00000122367:LDB3:chrl0:+:88446825:88447029:8 ENSGOOOOO 162241 : SLC25A45 :chrll:- :69124580:69124661:69120768:69126948 8441560:88451652 :65146846:65147032:65144547:65147337 ENSG00000050820:BCARl:chrl6:- ENSG00000076864:RAPlGAP:chrl:- ENSG00000048028:USP28:chrl 1 :- :75271080:75271242:75269884:75276367 :21930150:21930405:21929406:21932558 : 113677210: 113677306: 113675768: 113679019 ENSG00000165650:PDZD8:chrl0:- ENSG00000127603:MACFl:chrl:+:39930766:39930784:3 ENSG00000134444:KIAA1468:chrl8:+:59947592:59947675:5 : 119100490: 119100613: 119078485: 119133866 9929358:39934286 9947089:59947878 ENSG00000169045:HNRNPHl:chr5:- ENSGOOOOO 140307 :GTF2A2 :chrl 5 : - ENSG00000124275:MTRR:chr5:+:7873485:7873625:7871036: : 179046269: 179046408: 179045324: 179047892 :59944404:59944525:59934461:59949604 7875370

ENSG00000135093:USP30:chrl2:+: 109495730: 10949591 ENSGOOOOO 116731 :PRDM2:chrl :+: 14099572: 14099683 : 1 ENSG00000276087:RP11- 3:109494596:109505328 4075982:14142921 507M3:chr2:+:24362239:24362320:24358057:24369617

ENSG00000103034:NDRG4:chrl6:+:58534891:58534981 ENSG00000137842:TMEM62:chrl5:+:43470804:4347090 ENSG00000116750:UCHL5:chrl:-

:58528912:58537701 9:43461875:43473378 : 192989436: 192989511 : 192985525: 192990226

ENSG00000153113 :CAST:chr5:+:96062497:96062563 :96 ENSG00000060339:CCARl:chrl0:+:70516029:70516240: ENSG00000130731:METTL26:chrl6:-

058402:96063192 70515293:70517050 :685280:685340:684797:686093

ENSG00000151466:SCLTl:chr4:- ENSG00000070808 :CAMK2A:chr5 : - ENSG00000114268:PFKFB4:chr3:-

: 129864150: 129864343: 129812292: 129867161 : 149607754: 149607849: 149602780: 149618262 :48562997:48563102:48561263:48572944

ENSG00000085978:ATG16Ll:chr2:+:234182636:234182 ENSGOOOOO 116604 :MEF2D : chrl : - ENSG00000139613:SMARCC2:chrl2:-

687:234182423:234183321 : 156446285: 156446306: 156445029: 156446803 : 56558086:56558152:56557549:56558431

ENSG00000173947:PIFO:chrl :+: 111890295 : 111890394: 1 ENSGOOOOO 124831 :LRRFIP1 :chr2:+:238647874:2386479 ENSG00000168802:CHTF8:chrl6:- 11889671:111892727 52:238636578:238657006 :69154955:69155073:69152428:69155338

ENSG00000166979:EVAlC:chr21:+:33829904:33830028: ENSG00000197535:MY05A:chrl5:- ENSG00000109339:MAPK10:chr4:-

33785321:33840003 :52641014:52641023:52638658:52643450 :87010358:87010430:86989108:87022204

ENSG00000169241:SLC50Al:chrl:+: 155110036: 155110 ENSG00000068400:GRIPAPl:chrX:- ENSG00000213995:NAXD:chrl3:+: 111279785: 111279894: 11

198:155108852:155110454 :48838206:48838284:48838103:48839390 1267994:111286891

ENSG00000047346:FAM214A:chrl5:- ENSG00000127603:MACFl:chrl:+:39844132:39844195:3 ENSG00000056586:RC3H2:chr9:-

:52892323 :52892432:52885933 :52893282 9838268:39844874 : 125620201: 125620372: 125618157: 125620947

ENSG00000130731:METTL26:chrl6:- ENSG00000197530:MIB2:chrl:+: 1560937: 1561033: 15608 ENSG00000136527:TRA2B:chr3:-

:685517:685774:684797:686093 08:1562029 : 185649364: 185649640: 185644522: 185655612

ENSG00000132589:FLOT2:chrl7:- ENSG00000089177:KIF16B:chr20:- ENSG00000143537:ADAM15:chrl:+: 155034379: 155034593:1

:27212874:27212965:27211333:27215962 : 16362742: 16362775: 16362392: 16385457 55033965:155034720

ENSG00000090554:FLT3LG:chrl9:+:49982219:4998230 ENSG00000205571:SMN2:chr5:+:69372347:69372401:69 ENSG00000136717:BINl:chr2:-

4:49979823:49983554 366578:69372845 : 127815048: 127815177: 127808819: 127816586

ENSG00000118007: STAG1 :chr3 :- ENSG00000075413:MARK3:chrl4:+: 103966492: 1039665 ENSG00000137177:KIF13A:chr6:-

: 136287606: 136287703: 136261037: 136323150 37:103958371:103969218 : 17771344: 17771449: 17765177: 17772138

ENSGOOOOO 175287:PHYHD 1 :chr9 :+: 131700035 : 1317002 ENSG00000165795:NDRG2:chrl4:- ENSG00000081692:JMJD4:chrl:-

23:131698924:131703723 :21486615:21486630:21486398:21486921 :227920629:227920728:227920377:227921114

ENSGOOOOO 166444 : ST5 :chrl 1 : - ENSG00000105662:CRTCl:chrl9:+: 18854917: 18854965: ENSG00000153391:IN080C:chrl8:-

:8751496:8752756:8747756:8772167 18853836:18856632 :33059263 :33059375:33058313:33077682

ENSGOOOOO 135596 :MICAL 1 : chr6 : - ENSG00000175224:ATG13:chrll:+:46686398:46686509: ENSG00000118454:ANKRD13C:chrl:-

: 109772802: 109772903 : 109767975: 109773448 46681035:46686932 :70736538:70736639:70728530:70740402

ENSG00000159596:TMEM69:chrl:+:46156645:46156782 ENSGOOOOO 105426 :PTPRS :chrl 9: - ENSG00000061938:TNK2:chr3:-

:46153947:46158875 :5216730:5216778:5215606:5218430 : 195596367:195596412:195595580:195596984

ENSG00000142949:PTPRF:chrl:+:44067741:44067768:4 ENSG00000160055:TMEM234:chrl:- ENSG00000175575:PAAFl:chrll:+:73597973:73598144:7358

4064584:44069086 :32681984:32682118:32681396:32682489 9864:73598398

ENSG00000185024:BRFl:chrl4> ENSG00000170791:CHCHD7:chr8:+:57125320:57125468 ENSG00000149179:Cllorf49:chrll:+:47008758:47008861:46

: 105707601: 105707751: 105695250: 105718843 :57124396:57127156 958402:47073938 ENSG00000127527:EPS15Ll:chrl9 EN SGOOOOO 102882 :MAPK3 : chrl 6 : - ENSG00000168958:MFF:chr2:+:228211941:228212100:22820

: 16487932: 16488065 : 16472795 : 16495939 :30128457:30128606:30128324:30128990 5096:228217229 ENSG00000130731:METTL26:chrl6> ENSG00000008441:NFIX:chrl9:+: 13189426: 13189549: 13 ENSG00000130731:METTL26:chrl6:-

:685611:685774:684797:686093 186485:13192493 :684888:685063 :684797:686093

ENSG00000111790:FGFR10P2:chrl2:+:27113447:27113 561:27110676:27116274 ENSG00000124831:LRRFIPl:chr2:+:238659842:238659914:238657967 :238661951

Table 3b. IRIS prediction of AS-derived TCR and CAR-T targets for 22 GBM samples, b. Prioritized CAR-T targets listed by unique splice junction. ENSG00000069849: ATP 1B3 :chr3 :+: 141620977: 1416 ENSGOOOOO 142949:PTPRF:chrl _: +:44067741 :440677 ENSG00000172663:TMEM134:chrll:- 21069:141595752:141622461 68:44064584:44069086 :67232526:67232571 :67232327 :67234782 ENSG00000069849: ATP 1B3 :chr3 :+: 141620977: 1416 ENSG00000143434:SEMA6C:chrT- ENSG00000173264:GPR137:chrll:+:64055536:64055 21069:141596404:141622461 : 151108923: 151109055: 151108639: 151109332 686:64055418:64055811 ENSG00000073008:PVR:chrl9:+:45162009:4516216 ENSG00000143434:SEMA6C:chrT- ENSG00000177663:IL17RA:chr22:+: 17586742: 17586 8:45157286:45164558 : 151110791: 151110882: 151110581: 151111105 844:17586492:17588616

ENSG00000073008:PVR:chrl9:+:45162009:4516216 ENSGOOOOO 144857:BOC:chr3:+: 112991915: 112992 ENSG00000177943:MAMDC4:chr9:+: 139752637: 139

8:45161178:45164558 188:112991550:112993221 752728:139752549:139752851

ENSG00000074181 :NOTCH3 :chr 19 ENSGOOOOO 144935 :TRPC1 :chr3 :+: 142496473 : 14249 ENSG00000184916:JAG2:chrl4:-

: 15295105: 15295261:15292612: 15295716 6605:142467302:142521010 : 105617327: 105617441: 105617248: 105617619

ENSG00000076351 : SLC46A1 :chrl7:- ENSGOOOOO 147100: SLC16A2:chrX:+:73749047:737 ENSG00000186470:BTN3A2:chr6:+:26373124:26373

:26729255:26729339:26727783:26731633 49276:73745728:73751167 325:26370831:26373503

ENSG00000084234:APLP2:chrll:+: 129993506: 1299 ENSGOOOOO 147852: VLDLR:chr9:+:2651414:265149 93674: 129992408: 129996594 8:2650516:2651873

ENSG00000089472:HEPH:chrX:+:65474876:6547498 ENSGOOOOO 152154:TMEM178A:chr2:+:39931220:3

3:65428088:65478681 9931334:39893514:39944149

ENSG00000090554:FLT3LG:chrl9:+:49982219:4998 ENSGOOOOO 152154:TMEM178A:chr2:+:39934188:3 2304:49979823:49983554 9934326:39893514:39944149 ENSG00000091129 :NRCAM:chr7 : - ENSGOOOOO 152154:TMEM178A:chr2:+:39934188:3 : 107880402: 107880614: 107875132: 107953108 9934326:39931334:39944149 ENSG00000092421 : SEMA6 A:chr5 : - ENSGOOOOO 160613 :PCSK7:chrll:- : 115808580:115808631 : 115803443 : 115808768 : 117078369:117078451 : 117077876:117078685 ENSG00000099957:P2RX6:chr22:+:21380299:21380 ENSGOOOOO 160781 :PAQR6 :chr 1 : - 365:21380187:21380708 : 156214932: 156215029: 156214702: 156215325

ENSG00000099957:P2RX6:chr22:+:21380299:21380 ENSGOOOOO 16234 l:TPCN2:chrll:+:68848867:6884

618:21380187:21380708 8967:68846488:68902902

ENSG00000099998 : GGT5 :chr22 :- ENSGOOOOO 16234 l:TPCN2:chrll:+:68852677:6885

:24616459:24616552:24616084:24620963 2754:68851484:68902902

ENSG00000101187:SLC04Al:chr20:+:61299363:612 ENSGOOOOO 16353 l:NFASC:chrl:+:204919684:2049

99536:61299262:61299828 19702:204913534:204921138

ENSG00000102181: CD99L2 :chrX: - ENSGOOOOO 163531 :NFASC:chrl :+:204931235 :2049

: 149983334: 149983409: 149963959: 149999703 31286:204926954:204937376

ENSGOOOOO 102312:PORCN:chrX:+:48372514:48372 ENSGOOOOO 163531 :NFASC:chrl :+:204971723 :2049

529:48371240:48372627 71876:204957934:204978684

ENSGOOOOO 105426:PTPRS:chrl9:- ENSGOOOOO 163681 :SLMAP:chr3:+:57911571:57911

:5218797:5218809:5218543:5219320 661:57908750:57913022

ENSGOOOOO 114948: AD AM23:chr2:+:207474633:207 ENSGOOOOO 164199: ADGRVl:chr5:+:90445846:904

474724:207460886:207482302 46038:90398157:90459598

ENSGOOOOO 117114: ADGRL2:chrl:+:82418670:8241 ENSG00000166073:GPR176:chrl5:-

8709:82417826:82421560 :40099206:40099398:40094455:40212055

ENSGOOOOO 117335 :CD46:chrl:+:207941123:207941 ENSG00000166073:GPR176:chrl5:- 168:207940540:207943665 :40099206:40099459:40094455:40212055

Table 4. Summary results for seven selected AS-derived tumor-associated epitopes for dextramer-based T-cell recognition testing

Table 5. Summary results of dextramer-based T-cell recognition testing of seven AS-derived tumor epitopes using PBMCs and TILs from six patients and six healthy donors with two different HLA types. Data are shown normalized to results with nonhuman epitope NI3233 as a negative control. A common virus found in 50-80% of the population, cytomegalovirus (CMV) was included as a control (Macguire et al., Methods, 2017). n/a, results not available. Green, 'positive' reactivity; yellow, 'marginal' reactivity; red, 'negative' reactivity. a. Results for HLA-A03:01

b. Results for HLA-A02:01

Table 6. Summary results for TCR clonotypes of KIGRLVTRK (SEQ ID NO:29)-positive T cells from one patient, profiled by single-cell and bulk RNA-seq based approaches. Amino acid sequences of TCR CDR3 and frequencies of clonotypes by scRNA-seq, pairSEQ, and immunoSEQ are shown.

Table 7A HLA-A*01:01 peptide embodiments

Table 7B HLA-A*02:01 peptide embodiments

Table 7C-1 HLA-A*03:01 peptide embodiments

Table 7C-2 HLA-A*03:01 peptide embodiments

* * *

[0319] All of the methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

101312188.1 ³ - ⁴⁰ ,40 References

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