Title:
IMAGING AND TREATMENT OF PATHOPHYSIOLOGIC CONDITIONS BY CERENKOV RADIATION
Document Type and Number:
WIPO Patent Application WO/2015/183346
Kind Code:
A3
Abstract:
The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (GRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Gerenkov radiation-induced therapy (GRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Gerenkov radiation (GR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering GRIT to the target tissue in the subject.
Inventors:
ACHILEFU SAMUEL (US)
KOTAGIRI NALINIKANTH (US)
KOTAGIRI NALINIKANTH (US)
Application Number:
PCT/US2015/014095
Publication Date:
February 04, 2016
Filing Date:
February 02, 2015
Export Citation:
Assignee:
UNIV WASHINGTON (US)
International Classes:
A61M36/00
Foreign References:
| US20120282185A1 | 2012-11-08 | |||
| US20130137916A1 | 2013-05-30 | |||
| US20120220870A1 | 2012-08-30 | |||
| US20070218049A1 | 2007-09-20 | |||
| US20090202650A1 | 2009-08-13 | |||
| US20070292353A1 | 2007-12-20 | |||
| US20100209479A1 | 2010-08-19 | |||
| US20060019876A1 | 2006-01-26 | |||
| US20120101427A1 | 2012-04-26 | |||
| US20130017266A1 | 2013-01-17 |
Attorney, Agent or Firm:
RILEY-VARGAS, Rebecca et al. (Mark Twain Plaza III105 West Vandalia, Suite 40, Edwardsville IL, US)
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