Title:
IMIDAZOPYRIDAZINE AND IMIDAZOPYRAZINE COMPOUNDS AS INHIBITORS OF CDK7
Document Type and Number:
WIPO Patent Application WO/2022/061155
Kind Code:
A9
Abstract:
Compounds having activity as anti-cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or tautomer, thereof, wherein X, Y, R1, R2, R3 R4, R5 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).
Inventors:
KASIBHATLA SRINIVAS RAO (US)
SHARMA SUNIL (US)
KAADIGE MOHAN (US)
WESTON ALEXIS (US)
DANA SRIKANTA (US)
THODE TRASON (US)
SHARMA SUNIL (US)
KAADIGE MOHAN (US)
WESTON ALEXIS (US)
DANA SRIKANTA (US)
THODE TRASON (US)
Application Number:
PCT/US2021/050936
Publication Date:
August 04, 2022
Filing Date:
September 17, 2021
Export Citation:
Assignee:
TRANSLATIONAL GENOMICS RES INST (US)
International Classes:
C07D487/04; A61K31/4985; A61K31/5025; A61P35/00
Attorney, Agent or Firm:
KHANNA, Hemant et al. (US)
Download PDF: