IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

Title:

IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

Document Type and Number:

WIPO Patent Application WO/2013/163244

Kind Code:

A8

Abstract:

The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.

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Inventors:

LAWRENCE R MICHAEL (US)
MILLER MICHAEL M (US)
SEIFFERT DIETMAR ALFRED (US)
POSY SHOSHANA L (US)
WONG PANCRAS C (US)
BANVILLE JACQUES (CA)
RUEDIGER EDWARD H (CA)
DEON DANIEL H (CA)
MARTEL ALAIN (CA)
TREMBLAY FRANCOIS (CA)
GUY JULIA (CA)
LAVALLEE JEAN-FRANCOIS (CA)
GAGNON MARC (CA)

Application Number:

PCT/US2013/037892

Publication Date:

April 03, 2014

Filing Date:

April 24, 2013

Export Citation:

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Assignee:

BRISTOL MYERS SQUIBB CO (US)
UNIV MONTREAL (CA)

International Classes:

C07D519/00; A61K31/433; A61K31/4439; A61P7/02; C07D513/04

Attorney, Agent or Firm:

BOGIE, Terence, J. et al. (P.O. Box 4000Princeton, NJ, US)

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