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Title:
IMMUNITY INDUCER FOR SACCHARIDE ANTIGENS
Document Type and Number:
WIPO Patent Application WO/2014/178195
Kind Code:
A1
Abstract:
The present invention provides an immunity inducer and an immunity inducing method using same. The immunity inducer has an immunopotentiation effect on any target oligosaccharide antigen, in particular oligosaccharide antigens included in mammal-derived glycoprotein N-linked sugar chains; is capable of providing a monoclonal antibody having high specificity to and affinity with target oligosaccharide antigens; and has as an effective component thereof a glycolipid including a target oligosaccharide antigen (R) and indicated by general formula (2), or a salt thereof. General formula (2): R-Z-Y-CH(NH-CO-(CH2)n1-CH3)-(CH2)n2-CH3 (in the formula, R indicates a straight-chain or branched oligosaccharide comprising 2-30 of at least one type of monosaccharide. Z indicates a single bond, O, S or NH, a linker bound to thiomethyl, amino methylated sugar alcohol. Y indicates -(CH2)m-. n1 indicates an integer of 2-40, n2 indicates an integer of 1-27, and m indicates an integer of 1-30).

Inventors:
OKUDA TETSUYA (JP)
SHIMIZU HIROKI (JP)
Application Number:
PCT/JP2014/002401
Publication Date:
November 06, 2014
Filing Date:
May 02, 2014
Export Citation:
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Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
International Classes:
C07K16/00; A61K31/702; A61K39/00; A61P37/04; C07H15/02; C08B37/00
Foreign References:
JPH03275694A1991-12-06
JPH03279394A1991-12-10
JP2008514686A2008-05-08
JP2011524417A2011-09-01
JP3495740B22004-02-09
JPS6163700A1986-04-01
JP2008013497A2008-01-24
Other References:
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Attorney, Agent or Firm:
SAEKI, Norio et al. (JP)
Norio Saeki (JP)
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