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Title:
IMMUNOCHROMATOGRAPHY
Document Type and Number:
WIPO Patent Application WO/2021/065144
Kind Code:
A1
Abstract:
Provided is immunochromatography having a high detection sensitivity. The immunochromatography involves: a mixing step of mixing a sample that may contain an antigen with modified magnetic particles which are magnetic particles modified with a substance having an affinity specifically for the antigen, thereby obtaining a mixture containing a magnetic particle complex; a collection step of using magnetism to collect the magnetic particles; a separation step of mixing the collected magnetic particles with a separation solution in an amount that is less than the sample that may contain the antigen to separate the modified magnetic particles and obtain an antigen concentrate solution; a neutralization step of obtaining a neutralized antigen concentrate solution; a development step of forming a gold particle complex, which is a complex between the antigen in the neutralized antigen concentrate solution and modified gold particles that are gold particles modified with a first binding substance, and in this state, proceeding with development into an insoluble support having a reactive site wherein a second binding substance has been fixed; a trapping step of trapping the gold particle complex in the reactive site; and a silver enhancement step of enhancing the gold particle complex with silver.

Inventors:
ABURAYA YOSHIHIRO (JP)
NISHIKAWA NAOYUKI (JP)
KATADA JUNICHI (JP)
WADA ATSUHIKO (JP)
UJIHARA DAI (JP)
Application Number:
PCT/JP2020/027056
Publication Date:
April 08, 2021
Filing Date:
July 10, 2020
Export Citation:
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Assignee:
FUJIFILM CORP (JP)
International Classes:
G01N33/543; G01N33/53
Attorney, Agent or Firm:
NAKASHIMA Junko et al. (JP)
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