Title:
IMMUNOEVASIVE ANTI-TUMOR ADENOVIRUS
Document Type and Number:
WIPO Patent Application WO/2021/194183
Kind Code:
A1
Abstract:
The present invention relates to an anti-tumor adenovirus that can evade the in-vivo immune system. The adenovirus having high ability to kill tumor of the present invention, by comprising a nucleic acid encoding a tumor albumin-binding domain, has significantly increased effects of infecting and killing tumor cells, exhibits an increase in binding with albumin to thereby evade in-vivo immune responses, leading to an increase in plasma half-life, is specifically delivered to cancer cells to produce systemic therapeutic effects, and can be topically delivered and has excellent selectivity, resulting in a remarkable effect in anti-tumor efficacy and, therefore, the adenovirus can be advantageously used as an anticancer composition or anticancer adjuvant in various types of cancer.
Inventors:
CHOI JIN-WOO (KR)
PARK SEONG-HOON (KR)
PETER CHARLES GOUGHNOUR (KR)
YOO JUNG-KI (KR)
CHOI CHUNG-GAB (KR)
UM KI-HWAN (KR)
LEE HYUNG-BEEN (KR)
PARK SEONG-HOON (KR)
PETER CHARLES GOUGHNOUR (KR)
YOO JUNG-KI (KR)
CHOI CHUNG-GAB (KR)
UM KI-HWAN (KR)
LEE HYUNG-BEEN (KR)
Application Number:
PCT/KR2021/003491
Publication Date:
September 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
CURIGIN CO LTD (KR)
International Classes:
C12N7/00; A61K35/761; A61P35/00; C07K14/00
Foreign References:
| KR20160145825A | 2016-12-20 | |||
| KR20110096579A | 2011-08-30 | |||
| KR20140125834A | 2014-10-29 | |||
| US20150044280A1 | 2015-02-12 | |||
| KR20090007067A | 2009-01-16 | |||
| US99160197A | 1997-12-16 | |||
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| US5399680A | 1995-03-21 | |||
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| US5608142A | 1997-03-04 | |||
| US5998205A | 1999-12-07 | |||
| US5801029A | 1998-09-01 |
Other References:
"GenBank", Database accession no. AY339865.1
HITOSHI NIWA ET AL., GENE, vol. 108, 1991, pages 193 - 199
ODELL ET AL., NATURE, vol. 313, 1985, pages 810 - 812
MCELROY ET AL., PLANT CELL, vol. 2, 1990, pages 163 - 171
CHRISTENSEN ET AL., PLANT MOL. BIOL., vol. 12, 1989, pages 619 - 632
"UniProt", Database accession no. P 11819
ALTSCHUL, S. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
CHILLONBOSCH: "Methods in Molecular Biology", vol. 1089, 2014, SPRINGER PROTOCOLS, article "Adenovirus. Methods and Protocols"
ALEMANY RZHANG W: "Oncolytic adenoviral vectors", 1999, HUMANA PRESS
HITOSHI NIWA ET AL., GENE, vol. 108, 1991, pages 193 - 199
ODELL ET AL., NATURE, vol. 313, 1985, pages 810 - 812
MCELROY ET AL., PLANT CELL, vol. 2, 1990, pages 163 - 171
CHRISTENSEN ET AL., PLANT MOL. BIOL., vol. 12, 1989, pages 619 - 632
"UniProt", Database accession no. P 11819
ALTSCHUL, S. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
CHILLONBOSCH: "Methods in Molecular Biology", vol. 1089, 2014, SPRINGER PROTOCOLS, article "Adenovirus. Methods and Protocols"
ALEMANY RZHANG W: "Oncolytic adenoviral vectors", 1999, HUMANA PRESS
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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