Title:
IMMUNOSUPPRESSIVE COMPOSITION COMPRISING CHITOSAN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/060792
Kind Code:
A1
Abstract:
The present invention relates to an immunosuppressive composition comprising chitosan and, more specifically, to an immunosuppressive composition comprising chitosan that has a degree of deacetylation of 89% or higher and a molecular weight of 5 kda or less and induces inactive helper T cells to differentiate into regulatory T cells, and a pharmaceutical composition comprising the immunosuppressive composition as an active ingredient for prevention or treatment of immune diseases or inflammatory diseases. Thorough and intensive research, conducted by the present inventors with the aim of applying chitosan to the treatment of autoimmune diseases such as allergies, inflammatory diseases, etc., caused by excessive immune responses, resulted in first revealing the range of molecular weights and the degree of acetylation in chitosan that induces an immunosuppressive response. The chitosan induces inactive helper T cells to differentiate into CD4+Foxp3+ regulatory T cells which then secrete IL-10 to suppress an immune response, and thus is expected to find advantageous applications in the treatment of immune diseases or inflammatory diseases.
Inventors:
HWANG DONG SOO (KR)
IM SIN-HYEOG (KR)
BYUN SEO HYUN (KR)
LEE SU YOUNG (KR)
LEE YOU JEONG (KR)
IM SIN-HYEOG (KR)
BYUN SEO HYUN (KR)
LEE SU YOUNG (KR)
LEE YOU JEONG (KR)
Application Number:
PCT/KR2020/012741
Publication Date:
April 01, 2021
Filing Date:
September 22, 2020
Export Citation:
Assignee:
POSTECH RES & BUSINESS DEV FOUND (KR)
International Classes:
A61K31/722; A23L33/125; A61K8/73; A61P29/00; A61P37/06; A61Q19/00
Foreign References:
| KR20130047855A | 2013-05-09 | |||
| US20050004057A1 | 2005-01-06 | |||
| KR101468479B1 | 2014-12-05 | |||
| KR20140094775A | 2014-07-31 | |||
| KR20190074157A | 2019-06-27 |
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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