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Title:
IMMUNOSUPPRESSIVE PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/135872
Kind Code:
A1
Abstract:
Provided are a drug, a pharmaceutical composition, or a pharmaceutical kit for immunosuppression, for the treatment of conditions such as psoriasis, comprising a forskolin derivative or a salt thereof and optionally a prostaglandin compound or a glucocorticoid compound. Further provided is a method for immunosuppression, comprising administration of a forskolin derivative or a salt thereof and optionally a prostaglandin compound or a glucocorticoid compound. Forskolin derivatives show promise as a class of small-molecule drugs for achieving immunosuppression using new mechanisms, for the treatment of conditions such as psoriasis, when used alone or in combination with other substances. Compared with first-line antibody drugs, forskolin derivatives have significant advantages in process and price, and have comparable efficacy and fewer side effects compared with the first-line drug calcipotriol betamethasone ointment.

Inventors:
GONG XIAOMING (CN)
Application Number:
PCT/CN2019/129945
Publication Date:
July 02, 2020
Filing Date:
December 30, 2019
Export Citation:
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Assignee:
SHANGHAI ARCHEUS BIOTECH CO LTD (CN)
International Classes:
A61K31/35; A61K31/00; A61K31/352; A61K31/54; A61P17/00; C07D311/92; C07D405/12; C07D407/12; C07D493/10; C07D497/10
Domestic Patent References:
WO1985003637A11985-08-29
Foreign References:
EP0650723A21995-05-03
US4883793A1989-11-28
US8400291W1984-02-24
EP0222413A21987-05-20
Other References:
W. REMY ET AL: "Prostaglandin E2 gel improvement of psoriatic lesions", INTERNATIONAL JOURNAL OF DERMATOLOGY, vol. 25, no. 4, 31 May 1986 (1986-05-31), pages 266 - 268, XP055715063, DOI: 10.1111/j.1365-4362.1986.tb02240.x
YE, LIUMAO ET AL: "Clinical observation on the action of a compound dexamethasone cream used for treating psoriasis", QINGHAI MEDICAL JOURNAL, vol. 29, no. 8, 20 August 1999 (1999-08-20), CN, pages 12 - 13, XP009521703, ISSN: 1007-3795
M.B PATEL: "Forskolin: a successful therapeutic phytomolecule", EAST AND CENTRAL AFRICAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 13, no. 1, 28 August 2014 (2014-08-28), pages 25 - 32, XP055715071
YASHASWINI SHARMA ET AL: "Coleus (plectranthus barbatus)–a multipurpose medicinal herb", INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, vol. 2, no. 3, 6 March 2011 (2011-03-06), pages 47 - 58, XP055715073
TOCHIRO TATEE ET AL.: "Forskolin Derivatives. I. Synthesis, and Cardiovascular and Adenylate Cyclase-Stimulating Activities of Water-Soluble Forskolins", CHEM. PHARM. BULL., vol. 44, 1996, pages 2274 - 2279
SHUNICHI KAMETANI ET AL.: "The Pharmacodynamics of 6-(3- Dimethylaminopropionyl)forskolin and a Possible Metabolite in Beagles", J OF PHARMACEUTICAL SCIENCES, vol. 85, 1995, pages 377 - 380
MUTSUHITO KIRURA ET AL.: "Pharmacokinetics and a simulation model of colforsin daropate, new forskolin derivative inotropic vasodilator, in patients undergoing coronary artery bypass grafting", PHARMACOLOGICAL RESEARCH, vol. 49, 2004, pages 275 - 281, XP055047484, DOI: 10.1016/j.phrs.2003.09.012
Y. KHANDELWAL ET AL.: "Cardiovascular Effect of New Water-Soluble Derivatives of Forskolin", J. MED. CHEM., vol. 31, 1988, pages 1872 - 1879
A. LAURENZA ET AL.: "Stimulation of Adenylate Cyclase by Water-Soluble Analogues of Forsklin", MOLECULAR PHARMACOLOGY, vol. 32, 1987, pages 133 - 139, XP009109285
BANSI LAL: "Hydroxyacyl Derivatives of Forskolin - their Positive Inotropic Activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1998, pages 2061 - 2073
K. B. SEAMON ET AL.: "Structure-Activity Relationship for Activation of Adenylate Cyclase by the Diterpene Forskolin and Its Derivatives", J. MED. CHEM., vol. 26, 1983, pages 436 - 442
CHOU, T. C. ET AL.: "Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors", ADV. ENZYME REGUL., vol. 22, 1984, pages 27 - 55, XP023796270, DOI: 10.1016/0065-2571(84)90007-4
YOKOYAMA, Y. ET AL.: "Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth", CANCER RES., vol. 60, 2000, pages 2190 - 2196
ZHOU, J. R. ET AL.: "Combined inhibition of estrogen-depdendent human breast carcinoma by soy and tea bioactive components in mice", INT. J. CANCER, vol. 108, 2004, pages 8 - 14
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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