Title:
IMPROVED HUMAN METHYLTHIOADENOSINE/ADENOSINE DEPLETING ENZYME VARIANTS FOR CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2021/141977
Kind Code:
A8
Abstract:
Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO- degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.
Inventors:
STONE EVERETT (US)
Application Number:
PCT/US2021/012291
Publication Date:
August 19, 2021
Filing Date:
January 06, 2021
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
C12N9/10; A61K47/60; A61P35/00; C07K16/28; C12N15/70
Attorney, Agent or Firm:
SCHNEPP, Amanda S.J. (US)
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