Title:
IMPROVEMENTS IN MACROLIDE PRODUCTION
Document Type and Number:
WIPO Patent Application WO1999058541
Kind Code:
A3
Abstract:
A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-halogenated solvent; and azithromycin which is free from halogenated organic solvent in a stable anhydrous form; or in the form of a solvate with non-halogenated solvent with the exception of water.
Inventors:
BOSCH IMMACULADA (ES)
CENTELLAS VICTOR (ES)
DIAGO JOSE (ES)
CENTELLAS VICTOR (ES)
DIAGO JOSE (ES)
Application Number:
PCT/EP1999/003134
Publication Date:
January 20, 2000
Filing Date:
May 06, 1999
Export Citation:
Assignee:
BIOCHEMIE SA (ES)
BOSCH IMMACULADA (ES)
CENTELLAS VICTOR (ES)
DIAGO JOSE (ES)
BOSCH IMMACULADA (ES)
CENTELLAS VICTOR (ES)
DIAGO JOSE (ES)
International Classes:
A61K31/7042; A61K31/7052; A61P31/04; C07H17/00; (IPC1-7): C07H17/00; A61K31/70
Foreign References:
EP0109253A2 | 1984-05-23 | |||
EP0467331A1 | 1992-01-22 | |||
EP0101186A1 | 1984-02-22 | |||
EP0298650A2 | 1989-01-11 | |||
EP0879823A1 | 1998-11-25 |
Other References:
CHEMICAL ABSTRACTS, vol. 121, no. 23, 5 December 1994, Columbus, Ohio, US; abstract no. 280442, VAJTNER, Z. ET AL: "Kinetics of azithromycin synthesis from azaerythromycin by the HPLC method" XP002122554
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